CN101031555A - 具有vap-1抑制活性的噻唑衍生物 - Google Patents
具有vap-1抑制活性的噻唑衍生物 Download PDFInfo
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- CN101031555A CN101031555A CNA200580031703XA CN200580031703A CN101031555A CN 101031555 A CN101031555 A CN 101031555A CN A200580031703X A CNA200580031703X A CN A200580031703XA CN 200580031703 A CN200580031703 A CN 200580031703A CN 101031555 A CN101031555 A CN 101031555A
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- Prior art keywords
- amino
- methyl
- thiazoles
- phenyl
- ethyl
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- 238000002360 preparation method Methods 0.000 claims description 141
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 141
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- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
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- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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Abstract
Description
化合物 | 人血浆SSAO |
参考实施例1(对照) | 0.033 |
制备实施例1 | 0.016 |
制备实施例3 | 0.0045 |
制备实施例7 | 0.015 |
制备实施例9 | 0.0026 |
制备实施例12 | 0.019 |
制备实施例14 | 0.014 |
制备实施例16 | 0.012 |
制备实施例19 | 0.032 |
制备实施例25 | 0.0057 |
Claims (21)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2004904196 | 2004-07-27 | ||
AU2004904196A AU2004904196A0 (en) | 2004-07-27 | Thiazole Derivatives Having VAP-1 Inhibitory Activity |
Publications (1)
Publication Number | Publication Date |
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CN101031555A true CN101031555A (zh) | 2007-09-05 |
Family
ID=35734947
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CNA200580031703XA Pending CN101031555A (zh) | 2004-07-27 | 2005-07-27 | 具有vap-1抑制活性的噻唑衍生物 |
Country Status (10)
Country | Link |
---|---|
US (1) | US20070254931A1 (zh) |
EP (1) | EP1786792B1 (zh) |
JP (1) | JP4978464B2 (zh) |
KR (1) | KR20070050932A (zh) |
CN (1) | CN101031555A (zh) |
AT (1) | ATE427941T1 (zh) |
CA (1) | CA2575411A1 (zh) |
DE (1) | DE602005013793D1 (zh) |
ES (1) | ES2324922T3 (zh) |
WO (1) | WO2006011631A2 (zh) |
Cited By (4)
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CN103459369A (zh) * | 2011-03-15 | 2013-12-18 | 安斯泰来制药株式会社 | 胍化合物 |
CN107661500A (zh) * | 2009-09-08 | 2018-02-06 | 生物结治疗公司 | Vap‑1抑制剂用于治疗纤维变性疾病的用途 |
CN107922379A (zh) * | 2015-08-06 | 2018-04-17 | 宇部兴产株式会社 | 取代胍衍生物 |
CN110114350A (zh) * | 2016-12-28 | 2019-08-09 | 宇部兴产株式会社 | 取代胍化合物 |
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JP5369257B2 (ja) | 2006-02-15 | 2013-12-18 | アッヴィ・インコーポレイテッド | 新規なアセチル−CoAカルボキシラーゼ(ACC)阻害薬およびそれらの糖尿病、肥満および代謝症候群での使用 |
WO2007095603A2 (en) * | 2006-02-15 | 2007-08-23 | Abbott Laboratories | Novel acetyl-coa carboxylase (acc) inhibitors and their use in diabetes, obesity and metabolic syndrome |
CN102920698A (zh) * | 2007-06-25 | 2013-02-13 | 株式会社·R-技术上野 | 用于与低氧或局部缺血有关的眼科疾病的组合物 |
JPWO2009051223A1 (ja) * | 2007-10-19 | 2011-03-03 | 株式会社アールテック・ウエノ | 白内障処置のための医薬組成物 |
US20090170770A1 (en) * | 2007-11-06 | 2009-07-02 | Ali Hafezi-Moghadam | Methods and compositions for treating conditions associated with angiogenesis using a vascular adhesion protein-1 (vap 1) inhibitor |
ES2442298T3 (es) * | 2008-01-18 | 2014-02-11 | Allergan, Inc. | Agentes alfa 2 adrenérgicos selectivos de subtipo y métodos para usarlos |
TWI437986B (zh) | 2008-01-31 | 2014-05-21 | R Tech Ueno Ltd | 噻唑衍生物及使用該衍生物作為vap-1抑制劑之用途 |
TWI490214B (zh) * | 2008-05-30 | 2015-07-01 | 艾德克 上野股份有限公司 | 苯或噻吩衍生物及該等作為vap-1抑制劑之用途 |
US20100216827A1 (en) * | 2008-10-21 | 2010-08-26 | Metabolex, Inc. | Aryl gpr120 receptor agonists and uses thereof |
FI20115234A0 (fi) | 2011-03-08 | 2011-03-08 | Biotie Therapies Corp | Uusia pyridatsinoni- ja pyridoniyhdisteitä |
EP2781521A4 (en) | 2011-10-19 | 2015-03-04 | Kowa Co | NOVEL COMPOUND OF SPIROINDOLINE AND THERAPEUTIC AGENT CONTAINING THE SAME |
CA2915163A1 (en) | 2013-06-12 | 2014-12-18 | Proximagen Limited | New therapeutic uses of enzyme inhibitors |
EP3131539B1 (en) | 2014-04-15 | 2018-12-05 | Pécsi Tudományegyetem | Semicarbazide-sensitive amine oxidase inhibitors for use as analgesics in traumatic neuropathy and neurogenic inflammation |
WO2015189534A1 (en) | 2014-06-12 | 2015-12-17 | Proximagen Limited | Vap-1 inhibitors for treating muscular dystrophy |
CN104478828B (zh) * | 2014-12-10 | 2016-07-06 | 漳州片仔癀药业股份有限公司 | 2-氨基-7-取代苯并噻唑类化合物及其制备方法与用途 |
JOP20200093A1 (ar) | 2015-01-09 | 2017-06-16 | Kyowa Kirin Co Ltd | طريقة لإنتاج مشتق ثيازول |
JP2018076236A (ja) | 2015-06-05 | 2018-05-17 | 株式会社アールテック・ウエノ | がんを処置するための医薬組成物 |
EP3386494A1 (en) | 2015-12-07 | 2018-10-17 | Benevolentai Cambridge Limited | Vap-1 inhibitors for treating pain |
PL3455216T3 (pl) * | 2016-05-12 | 2021-05-17 | Boehringer Ingelheim International Gmbh | Pochodne pirydynylowe, kompozycje farmaceutyczne i ich zastosowania jako inhibitory aoc3 |
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DE3264595D1 (en) * | 1981-01-08 | 1985-08-14 | Mitsui Toatsu Chemicals | N-(4-phenyl-2-thiazolyl)carbamate derivatives, process for their preparation, and medicinal composition containing same |
US4699928A (en) * | 1984-07-13 | 1987-10-13 | Merrell Dow Pharmaceuticals Inc. | Fluoroallylamine derivatives |
IT1181871B (it) * | 1985-04-01 | 1987-09-30 | Consiglio Nazionale Ricerche | Inibitori selettivi delle benzilamminossidasi rispetto ad altre amminossidasi |
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-
2005
- 2005-07-27 DE DE602005013793T patent/DE602005013793D1/de active Active
- 2005-07-27 CN CNA200580031703XA patent/CN101031555A/zh active Pending
- 2005-07-27 ES ES05768525T patent/ES2324922T3/es active Active
- 2005-07-27 KR KR1020077004487A patent/KR20070050932A/ko not_active Application Discontinuation
- 2005-07-27 EP EP05768525A patent/EP1786792B1/en not_active Not-in-force
- 2005-07-27 WO PCT/JP2005/014136 patent/WO2006011631A2/en active Application Filing
- 2005-07-27 CA CA002575411A patent/CA2575411A1/en not_active Abandoned
- 2005-07-27 AT AT05768525T patent/ATE427941T1/de not_active IP Right Cessation
- 2005-07-27 JP JP2007504792A patent/JP4978464B2/ja not_active Expired - Fee Related
- 2005-07-27 US US11/572,772 patent/US20070254931A1/en not_active Abandoned
Cited By (10)
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CN107661500A (zh) * | 2009-09-08 | 2018-02-06 | 生物结治疗公司 | Vap‑1抑制剂用于治疗纤维变性疾病的用途 |
CN103459369A (zh) * | 2011-03-15 | 2013-12-18 | 安斯泰来制药株式会社 | 胍化合物 |
CN103459369B (zh) * | 2011-03-15 | 2015-05-27 | 安斯泰来制药株式会社 | 胍化合物 |
US9051283B2 (en) | 2011-03-15 | 2015-06-09 | Astellas Pharma Inc. | Guanidine compound |
US9556160B2 (en) | 2011-03-15 | 2017-01-31 | Astellas Pharma Inc. | Guanidine compound |
CN107922379A (zh) * | 2015-08-06 | 2018-04-17 | 宇部兴产株式会社 | 取代胍衍生物 |
US10759781B2 (en) | 2015-08-06 | 2020-09-01 | Ube Industries, Ltd. | Substituted guanidine derivatives |
CN107922379B (zh) * | 2015-08-06 | 2020-11-06 | 宇部兴产株式会社 | 取代胍衍生物 |
CN110114350A (zh) * | 2016-12-28 | 2019-08-09 | 宇部兴产株式会社 | 取代胍化合物 |
CN110114350B (zh) * | 2016-12-28 | 2022-03-04 | 宇部兴产株式会社 | 取代胍化合物 |
Also Published As
Publication number | Publication date |
---|---|
CA2575411A1 (en) | 2006-02-02 |
JP4978464B2 (ja) | 2012-07-18 |
WO2006011631A3 (en) | 2006-04-20 |
ATE427941T1 (de) | 2009-04-15 |
WO2006011631A2 (en) | 2006-02-02 |
JP2008508188A (ja) | 2008-03-21 |
US20070254931A1 (en) | 2007-11-01 |
KR20070050932A (ko) | 2007-05-16 |
EP1786792A2 (en) | 2007-05-23 |
ES2324922T3 (es) | 2009-08-19 |
DE602005013793D1 (de) | 2009-05-20 |
EP1786792B1 (en) | 2009-04-08 |
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