CN100536828C - 具有多重壳的微胶囊及其制备方法 - Google Patents
具有多重壳的微胶囊及其制备方法 Download PDFInfo
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- CN100536828C CN100536828C CNB2003801081294A CN200380108129A CN100536828C CN 100536828 C CN100536828 C CN 100536828C CN B2003801081294 A CNB2003801081294 A CN B2003801081294A CN 200380108129 A CN200380108129 A CN 200380108129A CN 100536828 C CN100536828 C CN 100536828C
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Nutrition Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicinal Preparation (AREA)
- General Preparation And Processing Of Foods (AREA)
Abstract
Description
实施例# | 图# | 描述 | 填料(%) | 诱导期(hr) |
1 | 6 | 用于比较的多核一步法 | 62 | 41 |
2 | 7 | 在外壳中使用凝胶和多磷酸盐的两步法 | 59 | 50 |
3 | 8 | 在外壳中使用藻酸盐的两步法 | 53 | 55 |
4 | 9 | 在第二壳中掺入蜡和藻酸盐以及在第三壳中掺入凝胶和多磷酸盐的三步法 | 52 | 44 |
5 | 10 | 在壳中掺入蜡和藻酸盐的两步法 | 57 | 56 |
Claims (45)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US42336302P | 2002-11-04 | 2002-11-04 | |
US60/423,363 | 2002-11-04 |
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CN1731983A CN1731983A (zh) | 2006-02-08 |
CN100536828C true CN100536828C (zh) | 2009-09-09 |
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CNB2003801081294A Expired - Fee Related CN100536828C (zh) | 2002-11-04 | 2003-11-04 | 具有多重壳的微胶囊及其制备方法 |
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US (3) | US20050067726A1 (zh) |
EP (1) | EP1575561B1 (zh) |
JP (1) | JP4833553B2 (zh) |
KR (2) | KR20110112481A (zh) |
CN (1) | CN100536828C (zh) |
AT (1) | ATE470436T1 (zh) |
AU (1) | AU2003283101B2 (zh) |
BR (1) | BRPI0315977B8 (zh) |
CA (1) | CA2471821C (zh) |
DE (1) | DE60332958D1 (zh) |
DK (1) | DK1575561T3 (zh) |
ES (1) | ES2347045T3 (zh) |
HK (1) | HK1084054A1 (zh) |
MX (1) | MX272648B (zh) |
NZ (1) | NZ539777A (zh) |
WO (1) | WO2004041251A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103769020A (zh) * | 2014-01-21 | 2014-05-07 | 华南理工大学 | 一种双核微胶囊及其制备方法与应用 |
Families Citing this family (118)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1316558B9 (en) * | 2000-09-08 | 2005-12-07 | San-Ei Gen F.F.I., Inc. | Tetraphenylbacteriochlorin derivatives and compositions containing the same |
US6974592B2 (en) | 2002-04-11 | 2005-12-13 | Ocean Nutrition Canada Limited | Encapsulated agglomeration of microcapsules and method for the preparation thereof |
ES2347045T3 (es) | 2002-11-04 | 2010-10-25 | Ocean Nutrition Canada Limited | Microcapsulas que tienen multiples cortezas, y metodo para su preparacion. |
WO2005018794A1 (en) * | 2003-08-22 | 2005-03-03 | Danisco A/S | Microcapsules |
GB2388581A (en) * | 2003-08-22 | 2003-11-19 | Danisco | Coated aqueous beads |
DK1656026T3 (da) | 2003-08-22 | 2014-07-14 | Dupont Nutrition Biosci Aps | Sammensætning, der omfatter et bakteriocin og et ekstrakt fra en plante fra læbeblomstfamilien |
ES2235642B2 (es) * | 2003-12-18 | 2006-03-01 | Gat Formulation Gmbh | Proceso de multi-microencapsulacion continuo para la mejora de la estabilidad y almacenamiento de ingredientes biologicamente activos. |
US6969530B1 (en) | 2005-01-21 | 2005-11-29 | Ocean Nutrition Canada Ltd. | Microcapsules and emulsions containing low bloom gelatin and methods of making and using thereof |
US8034450B2 (en) * | 2005-01-21 | 2011-10-11 | Ocean Nutrition Canada Limited | Microcapsules and emulsions containing low bloom gelatin and methods of making and using thereof |
US20080206316A1 (en) * | 2005-01-27 | 2008-08-28 | Colin Barrow | Chromium-Fatty Acid Compounds and Methods of Making and Using Thereof |
EP2447356B1 (en) | 2005-06-07 | 2016-04-20 | DSM Nutritional Products AG | Eukaryotic microorganisms for producing lipids and antioxidants |
CN104473161A (zh) * | 2005-07-07 | 2015-04-01 | 帝斯曼营养品股份公司 | 含有输送装置的食物制品及其制造方法 |
US9968120B2 (en) * | 2006-05-17 | 2018-05-15 | Dsm Nutritional Products Ag | Homogenized formulations containing microcapsules and methods of making and using thereof |
PE20070482A1 (es) | 2005-08-26 | 2007-06-08 | Ocean Nutrition Canada Ltd | Metodo para remover y/o reducir esteroles a partir de aceites |
US7977498B2 (en) | 2005-08-26 | 2011-07-12 | Ocean Nutrition Canada Limited | Reduction of sterols and other compounds from oils |
ES2325039T3 (es) * | 2005-08-30 | 2009-08-24 | Firmenich S.A. | Ingredientes activos encapsulados, procedimientos de preparacion y usode los mismos. |
US9693967B2 (en) | 2005-09-07 | 2017-07-04 | Southwest Research Institute | Biodegradable microparticle pharmaceutical formulations exhibiting improved released rates |
EP1931387A4 (en) * | 2005-09-07 | 2012-07-11 | Southwest Res Inst | BIODEGRADABLE MICROTEILED PHARMACEUTICAL FORMULATIONS WITH IMPROVED RELEASE RATES |
US7614812B2 (en) * | 2005-09-29 | 2009-11-10 | Kimberly-Clark Worldwide, Inc. | Wiper with encapsulated agent |
US7485609B2 (en) * | 2005-09-29 | 2009-02-03 | Kimberly-Clark Worldwide, Inc. | Encapsulated liquid cleanser |
US7678399B2 (en) | 2005-12-05 | 2010-03-16 | Bunge Oils, Inc. | Phytosterol containing deep-fried foods and methods with health promoting characteristics |
US7442439B2 (en) * | 2005-12-28 | 2008-10-28 | Kimberly-Clark Worldwide, Inc. | Microencapsulated heat delivery vehicles |
US20070148448A1 (en) * | 2005-12-28 | 2007-06-28 | Kimberly-Clark Worldwide, Inc. | Microencapsulated delivery vehicles including cooling agents |
US20070149435A1 (en) * | 2005-12-28 | 2007-06-28 | Kimberly-Clark Worldwide, Inc. | Cleansing composition including microencapsulated delivery vehicles |
US20070148446A1 (en) * | 2005-12-28 | 2007-06-28 | Kimberly-Clark Worldwide, Inc. | Wipes including microencapsulated delivery vehicles and processes of producing the same |
US20070148459A1 (en) * | 2005-12-28 | 2007-06-28 | Kimberly-Clark Worldwide, Inc. | Microencapsulated delivery vehicles |
US20070145618A1 (en) * | 2005-12-28 | 2007-06-28 | Kimberly-Clark Worldwide, Inc. | Methods of making microencapsulated delivery vehicles |
US7914891B2 (en) * | 2005-12-28 | 2011-03-29 | Kimberly-Clark Worldwide, Inc. | Wipes including microencapsulated delivery vehicles and phase change materials |
US20070145619A1 (en) * | 2005-12-28 | 2007-06-28 | Kimberly-Clark Worldwide, Inc. | Processes for producing microencapsulated delivery vehicles |
US20070202185A1 (en) * | 2005-12-28 | 2007-08-30 | Kimberly-Clark Worldwide, Inc. | Microencapsulated Delivery Vehicles Having Fugitive Layers |
KR20090029699A (ko) * | 2006-04-07 | 2009-03-23 | 오션 뉴트리션 캐나다 리미티드 | 낮은 계면장력 물질을 가지는 에멀젼 및 마이크로캡슐, 제조방법 및 이용방법 |
US7497351B2 (en) | 2006-05-30 | 2009-03-03 | Kimberly-Clark Worldwide, Inc. | Wet wipe dispensing system |
US7654412B2 (en) * | 2006-05-30 | 2010-02-02 | Kimberly-Clark Worldwide, Inc. | Wet wipe dispensing system for dispensing warm wet wipes |
US7648046B2 (en) * | 2006-05-30 | 2010-01-19 | Kimberly-Clark Worldwide, Inc. | Dispensing system for dispensing warm wet wipes |
NZ573327A (en) * | 2006-06-05 | 2012-07-27 | Ocean Nutrition Canada Ltd | Microcapsules with improved shells |
US8221809B2 (en) * | 2006-06-22 | 2012-07-17 | Martek Biosciences Corporation | Encapsulated labile compound compositions and methods of making the same |
MX2009001346A (es) * | 2006-08-01 | 2009-04-17 | Ocean Nutrition Canada Ltd | Microbios productores de aceite y metodos de modificacion de los mismos. |
US9032971B2 (en) * | 2006-11-15 | 2015-05-19 | Philip Morris Usa Inc. | Moist tobacco product and method of making |
US8192841B2 (en) * | 2006-12-14 | 2012-06-05 | Kimberly-Clark Worldwide, Inc. | Microencapsulated delivery vehicle having an aqueous core |
WO2008085997A2 (en) | 2007-01-10 | 2008-07-17 | Ocean Nutrition Canada, Ltd. | Vegetarian microcapsules |
EP2120603B1 (en) * | 2007-02-13 | 2021-05-12 | S-Biotek af 15. marts 2006 1 ApS | Diet product comprising alginate |
US8356606B2 (en) | 2007-06-01 | 2013-01-22 | Philip Morris Usa Inc. | Production of micronized encapsulated tobacco particles for tobacco flavor delivery from an oral pouch |
US8940344B2 (en) | 2007-06-08 | 2015-01-27 | Philip Morris Usa Inc. | Capsule clusters for oral consumption |
CA2689590C (en) * | 2007-06-19 | 2017-06-06 | Martek Biosciences Corporation | Microencapsulating compositions, methods of making, methods of using and products thereof |
US9332774B2 (en) * | 2007-06-27 | 2016-05-10 | Bunge Oils, Inc. | Microencapsulated oil product and method of making same |
WO2009016091A1 (en) * | 2007-08-01 | 2009-02-05 | Unilever Plc | Coated particles |
US8312886B2 (en) | 2007-08-09 | 2012-11-20 | Philip Morris Usa Inc. | Oral tobacco product having a hydrated membrane coating and a high surface area |
US20100272859A1 (en) * | 2007-08-28 | 2010-10-28 | Pepsico, Inc. | Delivery and controlled release of encapsulated water-insoluble flavorants |
US9186640B2 (en) * | 2007-08-28 | 2015-11-17 | Pepsico, Inc. | Delivery and controlled release of encapsulated lipophilic nutrients |
US8469037B2 (en) | 2008-02-08 | 2013-06-25 | Philip Morris Usa Inc. | Pre-portioned moist product and method of making |
US7924142B2 (en) * | 2008-06-30 | 2011-04-12 | Kimberly-Clark Worldwide, Inc. | Patterned self-warming wipe substrates |
US20100028503A1 (en) * | 2008-07-30 | 2010-02-04 | Jimbay Peter Loh | Simultaneous Multiple Acervation Process |
US8551517B2 (en) | 2008-12-16 | 2013-10-08 | Kimberly-Clark Worldwide, Inc. | Substrates providing multiple releases of active agents |
BRPI0922486B1 (pt) | 2008-12-18 | 2017-03-14 | Firmenich & Cie | microcápsulas e suas respectivas utilizações |
US9167835B2 (en) | 2008-12-30 | 2015-10-27 | Philip Morris Usa Inc. | Dissolvable films impregnated with encapsulated tobacco, tea, coffee, botanicals, and flavors for oral products |
MX2011007856A (es) * | 2009-01-30 | 2011-08-15 | Unilever Nv | Emulsiones de aceite en agua. |
US9167847B2 (en) * | 2009-03-16 | 2015-10-27 | Philip Morris Usa Inc. | Production of coated tobacco particles suitable for usage in a smokeless tobacoo product |
US9687023B2 (en) * | 2009-10-09 | 2017-06-27 | Philip Morris Usa Inc. | Moist smokeless tobacco product for oral usage having on a portion of the outer surface at least one friction reducing strip that provides texture during use |
US8539958B2 (en) * | 2009-10-13 | 2013-09-24 | Philip Morris Usa Inc. | Oral moist smokeless tobacco products with net-structured gel coating and methods of making |
JP5560017B2 (ja) * | 2009-10-13 | 2014-07-23 | 旭化成ケミカルズ株式会社 | 脂肪酸、トリグリセリドまたはその混合物を含むマルチコアマイクロカプセルを含有する錠剤およびその製法 |
US8663671B2 (en) | 2009-11-05 | 2014-03-04 | Philip Morris Usa Inc. | Methods and compositions for producing hydrogel capsules coated for low permeability and physical integrity |
UA107962C2 (en) | 2010-03-26 | 2015-03-10 | Philip Morris Products Sa | Smoking accessories with heat-resistant sheet materials |
US9226524B2 (en) | 2010-03-26 | 2016-01-05 | Philip Morris Usa Inc. | Biopolymer foams as filters for smoking articles |
EP2552239A2 (en) * | 2010-03-26 | 2013-02-06 | Philip Morris Products S.A. | Solid flavor encapsulation by applying complex coacervation and gelation technology |
AR081743A1 (es) * | 2010-03-26 | 2012-10-17 | Philip Morris Prod | Fabricacion de capsulas de nucleo/caparazon de diferentes geometrias y tratamiento a partir de las mismas |
WO2011126165A1 (ko) * | 2010-04-09 | 2011-10-13 | 주식회사 포스코 | 유기계 부식억제제가 봉입된 고분자 캡슐, 그 제조방법, 이를 포함하는 조성물 및 이를 이용한 표면 처리 강판 |
MX364560B (es) * | 2010-09-20 | 2019-05-02 | Spi Pharma Inc Star | Proceso de microencapsulacion y producto. |
FR2969907B1 (fr) * | 2010-12-31 | 2014-03-07 | Capsum | Serie de capsules comprenant au moins une goutte de phase interne dans une goutte de phase intermediaire et procede de fabrication associe |
CN102526124B (zh) * | 2011-01-31 | 2013-11-20 | 成都科尔医药技术有限公司 | 一种中药粉体及其制备方法 |
DE102011018716A1 (de) * | 2011-04-26 | 2012-10-31 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Mikrokapsel, Stoffgemisch, technische Einrichtung und Verfahren zur Herstellung einer vereisungshemmenden Schicht |
AU2012265842A1 (en) * | 2011-06-07 | 2014-01-23 | SPAI Group Ltd. | Compositions and methods for improving stability and extending shelf life of sensitive food additives and food products thereof |
US20130004617A1 (en) * | 2011-07-01 | 2013-01-03 | Pepsico, Inc. | Coacervate complexes, methods and food products |
CN102977857B (zh) * | 2011-09-06 | 2015-12-09 | 比亚迪股份有限公司 | 一种相变储能微胶囊及其制备方法 |
US20140348977A1 (en) * | 2011-09-13 | 2014-11-27 | Riken Vitamin Co., Ltd. | Method for manufacturing multicore gelatin microcapsule |
US20130095210A1 (en) * | 2011-10-13 | 2013-04-18 | Pepsico, Inc. | Complex Coacervates and Aqueous Dispersions of Complex Coacervates and Methods of Making Same |
US8617610B2 (en) | 2012-05-21 | 2013-12-31 | Dsm Nutritional Products Ag | Compositions and methods for increasing the stability of food product additives |
WO2013175253A1 (en) | 2012-05-21 | 2013-11-28 | Ocean Nutrition Canada Limited | Compositions and methods for increasing the stability of food product additives |
GB201210156D0 (en) * | 2012-06-08 | 2012-07-25 | Imerys Minerals Ltd | Microcapsules |
CN112662469A (zh) | 2012-07-31 | 2021-04-16 | 帝斯曼营养产品股份公司 | 使用绿茶提取物抗氧化剂精炼油 |
IN2015KN00664A (zh) * | 2012-09-24 | 2015-07-17 | Firmenich & Cie | |
KR102152751B1 (ko) * | 2012-09-28 | 2020-09-07 | (주)아모레퍼시픽 | 식물 유래 당단백질을 포함하는 마이크로캡슐 |
FR2996466B1 (fr) * | 2012-10-09 | 2015-06-05 | Seppic Sa | Procede d'encapsulation par coacervation ne mettant pas en œuvre de reticulant toxique |
FR2996418B1 (fr) * | 2012-10-09 | 2015-05-29 | Seppic Sa | Compositions alimentaires comprenant des capsules obtenues par coacervation ne mettant pas en œuvre de reticulant toxique |
KR101362800B1 (ko) * | 2012-10-16 | 2014-02-14 | 한국식품연구원 | 피토스테롤이 함유된 프롤라민-양이온 폴리머 복합체 및 이의 제조방법 |
WO2014084423A1 (ko) * | 2012-11-30 | 2014-06-05 | (주)케이피티 | 스크럽-함유 감압파괴성 마이크로캡슐, 이의 제조방법 및 용도 |
US9873880B2 (en) | 2013-03-13 | 2018-01-23 | Dsm Nutritional Products Ag | Engineering microorganisms |
KR101691644B1 (ko) * | 2013-12-04 | 2017-01-03 | 주식회사 씨앤지 | 기능성 물질을 포함하는 고분자 미세 캡슐과 그 제조방법 |
US9528983B2 (en) * | 2014-05-12 | 2016-12-27 | Anna Merritt Holmes | Physicochemical modification and application of alginate gels for the controlled release of reagents in classical solution assays and microfluidic assays |
US10117839B2 (en) | 2014-08-05 | 2018-11-06 | Intervet Inc. | Encapsulation of hydrophobic biologically active compounds |
CN106572979B (zh) | 2014-08-07 | 2021-03-12 | 雀巢产品有限公司 | 递送体系 |
FR3031914B1 (fr) * | 2015-01-27 | 2019-06-07 | Calyxia | Procede d'encapsulation |
US9334430B1 (en) * | 2015-05-29 | 2016-05-10 | Sirrus, Inc. | Encapsulated polymerization initiators, polymerization systems and methods using the same |
EP3329900B1 (en) * | 2015-07-31 | 2024-03-20 | GC Corporation | Tooth whitening composition |
CN105286011B (zh) * | 2015-09-18 | 2018-05-15 | 华南理工大学 | 一种可溶性大豆多糖-大豆蛋白-姜黄素复合物及制备与应用 |
KR101722067B1 (ko) * | 2016-01-18 | 2017-04-07 | 주식회사 씨앤지 | 기능성 물질을 포함하는 고분자 미세 캡슐과 그 제조방법 |
CN105558354B (zh) * | 2016-01-26 | 2019-08-20 | 武汉轻工大学 | 饲用鱼油微胶囊及其制备工艺 |
US11419350B2 (en) | 2016-07-01 | 2022-08-23 | Corbion Biotech, Inc. | Feed ingredients comprising lysed microbial cells |
US10729168B2 (en) * | 2016-08-22 | 2020-08-04 | Incredible Foods, Inc. | Manufactured fruit compositions and methods of making |
EP3535377B1 (en) | 2016-11-01 | 2022-02-09 | Novozymes A/S | Multi-core granules |
DE102017111444A1 (de) | 2017-05-24 | 2018-11-29 | Henkel Ag & Co. Kgaa | Mikrokapselsystem für polysensorische Dufteffekte |
US20180346648A1 (en) * | 2017-05-30 | 2018-12-06 | International Flavors & Fragrances Inc. | Branched polyethyleneimine microcapsules |
CN107183767B (zh) * | 2017-06-08 | 2018-06-22 | 北京工商大学 | 一种单核食用油脂微胶囊及其制备方法 |
US20190070078A1 (en) * | 2017-09-05 | 2019-03-07 | Robb Akridge | Truffle configured cosmetic article |
CN111770788B (zh) * | 2018-03-13 | 2023-07-25 | 诺维信公司 | 使用氨基糖低聚物进行微囊化 |
DE102019123274A1 (de) | 2019-08-30 | 2021-03-04 | Carl Freudenberg Kg | Reinigungsartikel, der Mikrokapseln enthält |
US11793753B2 (en) | 2019-09-12 | 2023-10-24 | Nulixir Inc. | Methods and systems for forming layered solid particles |
US11497692B2 (en) | 2019-10-15 | 2022-11-15 | Rea Innovations, Inc. | Systems and methods for blending solid-shell cosmetic ingredient capsules and blendable cosmetic ingredient capsules |
US11660578B2 (en) | 2019-10-15 | 2023-05-30 | Rea Innovations, Inc. | Systems and methods for blending solid-shell cosmetic ingredient capsules and blendable cosmetic ingredient capsules |
FR3102912A1 (fr) * | 2019-11-07 | 2021-05-14 | Huddle Corp | Aliment ou complément alimentaire pour animaux d’élevage |
WO2021119810A1 (en) | 2019-12-17 | 2021-06-24 | 9286-3620 Québec Inc. | Oral delivery systems based on in situ forming protein/polysaccharide coacervates |
KR102303886B1 (ko) * | 2019-12-26 | 2021-09-23 | 한국과학기술원 | 삼중액적 기반의 이중막을 갖는 센서형 마이크로 캡슐 및 이의 제조방법 |
CN111955735B (zh) * | 2020-07-30 | 2022-04-29 | 中国农业大学 | 一种植物甾醇微胶囊的制备方法 |
KR102239512B1 (ko) * | 2020-09-10 | 2021-04-12 | 서울대학교산학협력단 | 다중기능성 마이크로캡슐 조성물 및 그 제조방법 |
KR20220075022A (ko) * | 2020-11-26 | 2022-06-07 | (주) 에이치엔에이파마켐 | 다층 구형 파티클의 제조 방법 및 이에 의해 제조된 다층 구형 파티클을 포함하는 화장료 조성물 |
DE102021205957A1 (de) * | 2021-06-11 | 2022-12-15 | Koehler Innovation & Technology Gmbh | Farbneutrale abbaubare Mikrokapseln |
GB202110132D0 (en) | 2021-07-14 | 2021-08-25 | Cpl Aromas Ltd | Microcapsules and methods for preparing microcapsules |
WO2023239944A2 (en) * | 2022-06-10 | 2023-12-14 | Phyto Tech Corp. | Biodegradable fragrance and/or flavor-loaded microcapsules |
CN115500516B (zh) * | 2022-09-28 | 2023-11-07 | 江苏恒康生物科技有限公司 | 益生菌缓释载体、缓释滴丸及其制备方法和应用 |
Family Cites Families (138)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1035319B (de) | 1952-05-07 | 1958-07-31 | Hoffmann La Roche | Verfahren zur Herstellung eines vitaminhaltigen Pulvers |
USRE24899E (en) * | 1953-06-30 | 1960-11-29 | Oil-containrab | |
US2800457A (en) * | 1953-06-30 | 1957-07-23 | Ncr Co | Oil-containing microscopic capsules and method of making them |
NL246985A (zh) * | 1958-12-31 | |||
NL125294C (zh) * | 1959-01-02 | 1900-01-01 | ||
NL262194A (zh) * | 1960-03-10 | 1900-01-01 | ||
US3526682A (en) * | 1966-08-23 | 1970-09-01 | Pfizer & Co C | Microencapsulation of pharmaceuticals |
SE344686B (zh) | 1968-01-29 | 1972-05-02 | Ncr | |
US3697437A (en) * | 1970-05-27 | 1972-10-10 | Ncr Co | Encapsulation process by complex coacervation using inorganic polyphosphates and organic hydrophilic polymeric material |
US4273672A (en) * | 1971-08-23 | 1981-06-16 | Champion International Corporation | Microencapsulation process |
JPS5814253B2 (ja) * | 1974-04-10 | 1983-03-18 | カンザキセイシ カブシキガイシヤ | ビシヨウカプセルノ セイゾウホウホウ |
JPS5833011B2 (ja) * | 1977-01-28 | 1983-07-16 | 神崎製紙株式会社 | マイクロカプセルの製造方法 |
US4222891A (en) * | 1977-08-17 | 1980-09-16 | Kanzaki Paper Mfg. Co., Ltd. | Method of making oil-containing microcapsules |
US4217370A (en) * | 1977-08-25 | 1980-08-12 | Blue Wing Corporation | Lipid-containing feed supplements and foodstuffs |
US4232084A (en) | 1978-01-25 | 1980-11-04 | Thalatta, Inc. | Sheets containing microencapsulated color-coded micromagnets |
JPS5655310A (en) * | 1979-10-15 | 1981-05-15 | Mitsubishi Paper Mills Ltd | Production of double-layered capsule |
GB2075458B (en) | 1980-04-21 | 1983-06-02 | Nicholas Pty Ltd | Encapsulation of indomethacin |
US4485172A (en) | 1981-01-19 | 1984-11-27 | Cpc International Inc. | Multistage process for the preparation of fats and oils |
NZ199218A (en) | 1981-01-19 | 1985-03-20 | Cpc International Inc | Production of fats and oils by cultivating yeast cells |
GB2115768A (en) | 1982-02-11 | 1983-09-14 | Kms Fusion Inc | Containment of hazardous fluids |
JPS58149645U (ja) | 1982-03-31 | 1983-10-07 | 東海ゴム工業株式会社 | 円筒形ト−シヨナルダンパ |
JPS59131355A (ja) * | 1983-01-17 | 1984-07-28 | 森下仁丹株式会社 | 多重軟カプセルの製法 |
US4808408A (en) * | 1983-05-11 | 1989-02-28 | Bend Research, Inc. | Microcapsules prepared by coacervation |
US4670247A (en) * | 1983-07-05 | 1987-06-02 | Hoffman-Laroche Inc. | Process for preparing fat-soluble vitamin active beadlets |
US5194615A (en) * | 1983-07-08 | 1993-03-16 | The William Seroy Group | Synthetic GTF chromium nicotinate material and its preparation |
US4954492A (en) * | 1983-07-08 | 1990-09-04 | The William Seroy Group | Synthetic GTF chromium material for decreasing blood lipid levels and process therefor |
US4923855A (en) * | 1983-07-08 | 1990-05-08 | The William Seroy Group | Synthetic GTF chromium material and process therefor |
US4749620A (en) * | 1984-02-15 | 1988-06-07 | Massachusetts Institute Of Technology | Encapsulated active material system |
US4744933A (en) * | 1984-02-15 | 1988-05-17 | Massachusetts Institute Of Technology | Process for encapsulation and encapsulated active material system |
US4963367A (en) * | 1984-04-27 | 1990-10-16 | Medaphore, Inc. | Drug delivery compositions and methods |
JPS61172807A (ja) | 1985-01-25 | 1986-08-04 | Ajinomoto Co Inc | 化粧料 |
CH672330A5 (zh) * | 1986-02-04 | 1989-11-15 | Zinser Textilmaschinen Gmbh | |
FR2608456B1 (fr) * | 1986-12-18 | 1993-06-18 | Mero Rousselot Satia | Microcapsules a base de gelatine et de polysaccharides et leur procede d'obtention |
JPH0665280B2 (ja) * | 1987-03-04 | 1994-08-24 | 味の素株式会社 | タンパクゲル化剤及びそれを用いるタンパクのゲル化方法 |
US4861627A (en) * | 1987-05-01 | 1989-08-29 | Massachusetts Institute Of Technology | Preparation of multiwall polymeric microcapsules |
IT1205043B (it) * | 1987-05-28 | 1989-03-10 | Innova Di Ridolfi Flora & C S | Procedimento per l'estrazione di esteri di acidi grassi poliinsaturi da olii di pesce e composizioni farmaceutiche e dietetiche contenenti detti esteri |
FR2623583B2 (fr) * | 1987-06-23 | 1990-04-20 | Hutchinson | Supports elastiques |
US4867986A (en) * | 1987-07-17 | 1989-09-19 | Pharmachem Laboratories, Inc. | Dry stabilized microemulsified omega-three acid-containing oils |
EP0301777A1 (en) | 1987-07-28 | 1989-02-01 | Queen's University At Kingston | Multiple membrane microencapsulation |
US4895725A (en) * | 1987-08-24 | 1990-01-23 | Clinical Technologies Associates, Inc. | Microencapsulation of fish oil |
WO1992011083A1 (en) | 1987-09-28 | 1992-07-09 | Redding Bruce K Jr | Apparatus and method for making microcapsules |
US5035896A (en) * | 1988-06-15 | 1991-07-30 | Warner-Lambert Company | Water insoluble drugs coated by coacervated fish gelatin |
US5330778A (en) * | 1988-09-19 | 1994-07-19 | Opta Food Ingredients, Inc. | Hydrophobic protein microparticles |
EP0434760B1 (en) | 1988-09-19 | 1994-01-12 | Opta Food Ingredients, Inc. | Hydrophobic protein microparticles and preparation thereof |
JP2619933B2 (ja) | 1988-09-21 | 1997-06-11 | ニッピゼラチン工業株式会社 | 高重合度ゼラチンの製造方法 |
US5059622A (en) * | 1989-08-29 | 1991-10-22 | Biosyn, Inc. | Method for reducing blood pressure levels in hypertensive persons |
US4946624A (en) * | 1989-02-27 | 1990-08-07 | The Procter & Gamble Company | Microcapsules containing hydrophobic liquid core |
CA2024587A1 (en) * | 1989-09-05 | 1991-03-06 | Bernard Ecanow | Drug delivery compositions based on biological cells or components thereof and methods |
US5204029A (en) * | 1989-09-25 | 1993-04-20 | Morgan Food Products, Inc. | Methods of encapsulating liquids in fatty matrices, and products thereof |
FI905333A0 (fi) | 1989-10-31 | 1990-10-29 | Warner Lambert Co | Foerkapslat brukssystem foer soetnings- och arommedel och foerfarande foer dess framstaellning. |
JP2571874B2 (ja) | 1989-11-06 | 1997-01-16 | アルカーメス コントロールド セラピューティクス,インコーポレイテッド | タンパク質マイクロスフェア組成物 |
US5013569A (en) | 1990-05-21 | 1991-05-07 | Century Laboratories, Inc. | Infant formula |
FR2663222A1 (fr) * | 1990-06-13 | 1991-12-20 | Medgenix Group Sa | Microcapsule de liquide huileux. |
DE4141351A1 (de) * | 1991-12-14 | 1993-06-17 | Basf Ag | Stabile pulverfoermige vitamin- und/oder carotinoid-praeparate und verfahren zu deren herstellung |
US5573934A (en) * | 1992-04-20 | 1996-11-12 | Board Of Regents, The University Of Texas System | Gels for encapsulation of biological materials |
US5759599A (en) | 1992-03-30 | 1998-06-02 | Givaudan Roure Flavors Corporation | Method of flavoring and mechanically processing foods with polymer encapsulated flavor oils |
ES2181691T5 (es) | 1992-06-11 | 2007-10-01 | Alkermes Controlled Therapeutics, Inc. | Sistema de distribucion de proteina eritropoyetina. |
DE69316326T2 (de) * | 1992-06-16 | 1998-08-13 | Fuji Oil Co Ltd | Emulgiermittel, emulgierende Zusammensetzung und pulverige Zusammensetsung |
EP0595030A3 (en) * | 1992-10-01 | 1995-06-07 | Tanabe Seiyaku Co | Composition of microspheres with several delayed release nuclei and its preparation process. |
US5378413A (en) * | 1993-01-21 | 1995-01-03 | The United States Of America As Represented By The Secretary Of The Navy | Process for preparing microcapsules having gelatin walls crosslinked with quinone |
GB9306808D0 (en) | 1993-04-01 | 1993-05-26 | Ciba Geigy Ag | Coated microparticle agglomerates |
JPH0731871A (ja) * | 1993-05-18 | 1995-02-03 | Canon Inc | 膜構造物 |
GB9315253D0 (en) * | 1993-07-23 | 1993-09-08 | Res Inst Medicine Chem | Chemical compounds |
US5853755A (en) * | 1993-07-28 | 1998-12-29 | Pharmaderm Laboratories Ltd. | Biphasic multilamellar lipid vesicles |
US5428014A (en) * | 1993-08-13 | 1995-06-27 | Zymogenetics, Inc. | Transglutaminase cross-linkable polypeptides and methods relating thereto |
US5997863A (en) | 1994-07-08 | 1999-12-07 | Ibex Technologies R And D, Inc. | Attenuation of wound healing processes |
WO1996011264A1 (fr) | 1994-10-11 | 1996-04-18 | Ajinomoto Co., Inc. | Transglutaminase stabilisee et preparation enzymatique contenant cette transglutaminase |
US5827531A (en) * | 1994-12-02 | 1998-10-27 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Microcapsules and methods for making |
US5603952A (en) * | 1994-12-30 | 1997-02-18 | Tastemaker | Method of encapsulating food or flavor particles using warm water fish gelatin, and capsules produced therefrom |
US5916790A (en) * | 1995-03-03 | 1999-06-29 | Metabolex, Inc. | Encapsulation compositions, and methods |
US5576097A (en) * | 1995-04-24 | 1996-11-19 | Brite-Line Industries, Inc. | High brightness durable retro-reflecting microspheres and method of making the same |
AU7261296A (en) * | 1995-10-12 | 1997-04-30 | Mccormick & Company, Inc. | Double encapsulation process and flavorant compositions prepared thereby |
DE19600285C2 (de) | 1996-01-05 | 1998-10-15 | Stoever Adolf Bautex Kg | Vorhangzug |
US5834232A (en) | 1996-05-01 | 1998-11-10 | Zymogenetics, Inc. | Cross-linked gelatin gels and methods of making them |
JP3555640B2 (ja) * | 1996-05-10 | 2004-08-18 | ライオン株式会社 | 天然カロチノイドを包含した多芯型構造のマイクロカプセル並びに錠剤、食品用及び医薬品用配合剤 |
JP3635801B2 (ja) | 1996-08-01 | 2005-04-06 | 味の素株式会社 | 乳ホエイ蛋白含有粉末及びこれを使用した加工食品 |
KR0173445B1 (ko) | 1996-09-17 | 1999-02-01 | 이능희 | 화장료용 이중캡슐 및 이를 함유하는 화장료 조성물 |
US5766637A (en) * | 1996-10-08 | 1998-06-16 | University Of Delaware | Microencapsulation process using supercritical fluids |
WO1998024415A1 (en) * | 1996-12-02 | 1998-06-11 | The Regents Of The University Of California | A bilayer structure which encapsulates multiple containment units and uses thereof |
US6039901A (en) | 1997-01-31 | 2000-03-21 | Givaudan Roure Flavors Corporation | Enzymatically protein encapsulating oil particles by complex coacervation |
IT1291113B1 (it) * | 1997-03-20 | 1998-12-29 | Sigma Tau Ind Farmaceuti | Composizione nutritiva terapeutica per soggetti affetti da diabete mellito |
GB9715444D0 (en) * | 1997-07-22 | 1997-09-24 | Scotia Holdings Plc | Therapeutic and dietary compositions |
ES2229443T3 (es) | 1997-08-22 | 2005-04-16 | Unilever N.V. | Procedimiento para la produccion de esteres de estanol. |
US6106875A (en) * | 1997-10-08 | 2000-08-22 | Givaudan Roure (International) Sa | Method of encapsulating flavors and fragrances by controlled water transport into microcapsules |
JPH11130698A (ja) * | 1997-10-31 | 1999-05-18 | Freunt Ind Co Ltd | アルギン酸多価金属塩球状微粒子集合体、該球状微粒子集合体に難溶性薬剤を担持した放出制御製剤及びそれらの製造方法 |
DE19801593A1 (de) | 1998-01-17 | 1999-07-22 | Henkel Kgaa | Lipoprotein-Cremes |
DE19830375A1 (de) * | 1998-07-08 | 2000-01-13 | K D Pharma Bexbach Gmbh | Mikroverkapselte ungesättigte Fettsäure oder Fettsäureverbindung oder Mischung aus Fettsäuren und/oder Fettsäureverbindungen |
DE19838189A1 (de) | 1998-08-24 | 2000-03-02 | Basf Ag | Stabile pulverförmige Vitamin- und Carotinoid-Zubereitungen und Verfahren zu deren Herstellung |
IT1304406B1 (it) * | 1998-10-21 | 2001-03-19 | Danital Italia S R L | Preparazione per la veicolazione di principi attivi basata su acidigrassi polinsaturi del gruppo omega 3. |
US6103378A (en) * | 1998-11-23 | 2000-08-15 | The Mead Company | Capsules having discrete solvent/color former and diluent capsule encapsulated phases |
JP2000244593A (ja) * | 1999-02-22 | 2000-09-08 | Sony Corp | 受信装置 |
ZA200003120B (en) | 1999-06-30 | 2001-01-02 | Givaudan Roure Int | Encapsulation of active ingredients. |
DE59908424D1 (de) * | 1999-07-02 | 2004-03-04 | Cognis Iberia Sl | Mikrokapseln - I |
AU6779200A (en) * | 1999-08-17 | 2001-03-13 | Luminex Corporation | Encapsulation of fluorescent particles |
US6328995B1 (en) * | 1999-09-24 | 2001-12-11 | Basf Aktiengesellschaft | Stable vitamin and/or carotenoid products in powder form and process for their production |
US6500463B1 (en) | 1999-10-01 | 2002-12-31 | General Mills, Inc. | Encapsulation of sensitive components into a matrix to obtain discrete shelf-stable particles |
AU782212B2 (en) | 1999-11-18 | 2005-07-14 | Quest International B.V. | Stable, spray-dried composition in a carbohydrate substrate and process for obtaining said composition |
DE10001172A1 (de) | 2000-01-13 | 2001-07-26 | Max Planck Gesellschaft | Templatieren von Feststoffpartikeln mit Polymermultischichten |
US6534926B1 (en) * | 2000-04-12 | 2003-03-18 | Tmc Enterprises, A Division Of Tasco Industries, Inc. | Portable fluorescent drop-light |
SE523211C2 (sv) | 2000-04-26 | 2004-04-06 | Skaanemejerier Ekonomisk Foere | Lipidkomposition omfattande en skyddande olja och en fleromättad fettsyra, emulsion innehållande en sådan komposition och förfarande för framställning av emulsionen |
AR023940A1 (es) * | 2000-05-03 | 2002-09-04 | Eriochem Sa | Procedimiento para la produccion de microcapsulas de liberacion prolongada de peptidos solubles en agua |
JP4695248B2 (ja) | 2000-07-18 | 2011-06-08 | 小川香料株式会社 | 皮膜が気密化されたマイクロカプセルの製造方法 |
US6365176B1 (en) * | 2000-08-08 | 2002-04-02 | Functional Foods, Inc. | Nutritional supplement for patients with type 2 diabetes mellitus for lipodystrophy |
US6441050B1 (en) * | 2000-08-29 | 2002-08-27 | Raj K. Chopra | Palatable oral coenzyme Q liquid |
US6809115B2 (en) | 2000-09-21 | 2004-10-26 | Nutrition 21, Inc. | Methods and compositions for the treatment of diabetes, the reduction of body fat, improvement of insulin sensitivity, reduction of hyperglycemia, and reduction of hypercholesterolemia with chromium complexes, conjugated fatty acids, and/or conjugated fatty alcohols |
US6300377B1 (en) * | 2001-02-22 | 2001-10-09 | Raj K. Chopra | Coenzyme Q products exhibiting high dissolution qualities |
CA2449199A1 (en) | 2001-05-30 | 2002-12-05 | Laxdale Limited | Coenzyme q and eicosapentaenoic acid (epa) |
US7163563B2 (en) | 2001-07-16 | 2007-01-16 | Depuy Products, Inc. | Unitary surgical device and method |
US20030044380A1 (en) * | 2001-07-19 | 2003-03-06 | Zhu Yong Hua | Adhesive including medicament |
US6544926B1 (en) | 2001-10-11 | 2003-04-08 | Appleton Papers Inc. | Microcapsules having improved printing and efficiency |
US6861458B2 (en) * | 2001-11-15 | 2005-03-01 | Xerox Corporation | Photoprotective and lightfastness-enhancing siloxanes |
US6652891B2 (en) * | 2001-12-12 | 2003-11-25 | Herbasway Laboratories, Llc | Co-enzyme Q10 dietary supplement |
US6974592B2 (en) * | 2002-04-11 | 2005-12-13 | Ocean Nutrition Canada Limited | Encapsulated agglomeration of microcapsules and method for the preparation thereof |
EP1371410A1 (en) | 2002-06-14 | 2003-12-17 | NIZO food research | Complex coacervates containing whey proteins |
JP2005529728A (ja) | 2002-06-18 | 2005-10-06 | マーテック・バイオサイエンシーズ・コーポレーション | 水溶液中の油の安定エマルジョンおよびその製造方法 |
WO2004022220A1 (en) * | 2002-09-04 | 2004-03-18 | Southwest Research Institute | Microencapsulation of oxygen or water sensitive materials |
ES2347045T3 (es) * | 2002-11-04 | 2010-10-25 | Ocean Nutrition Canada Limited | Microcapsulas que tienen multiples cortezas, y metodo para su preparacion. |
US8017651B2 (en) * | 2002-11-22 | 2011-09-13 | Bionexus, Ltd. | Compositions and methods for the treatment of HIV-associated fat maldistribution and hyperlipidemia |
CN1747784A (zh) | 2002-12-18 | 2006-03-15 | 荷兰联合利华有限公司 | 包含亲脂性核的复合凝聚层胶囊 |
EP1430947A1 (de) | 2002-12-21 | 2004-06-23 | Cognis Iberia, S.L. | Mikropartikel mit flüssigkristallinen Kompartimenten |
GB0319071D0 (en) | 2003-08-14 | 2003-09-17 | Avecia Ltd | Catalyst and process |
US20050118285A1 (en) | 2003-10-23 | 2005-06-02 | L'oreal | O/W emulsion containing aloe vera, uses thereof, method for making |
US6972592B2 (en) * | 2003-11-24 | 2005-12-06 | Lsi Logic Corporation | Self-timed scan circuit for ASIC fault testing |
WO2006078284A2 (en) | 2004-05-04 | 2006-07-27 | University Of South Carolina | Methods and compositions related to antiviral therapy using algae and cyanobacteria |
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JP5292899B2 (ja) | 2008-04-02 | 2013-09-18 | セイコーエプソン株式会社 | 流体噴射装置 |
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2003
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- 2003-11-04 WO PCT/CA2003/001699 patent/WO2004041251A1/en active Application Filing
- 2003-11-04 DE DE60332958T patent/DE60332958D1/de not_active Expired - Lifetime
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- 2003-11-04 BR BRPI0315977A patent/BRPI0315977B8/pt not_active IP Right Cessation
- 2003-11-04 DK DK03773376.3T patent/DK1575561T3/da active
- 2003-11-04 AT AT03773376T patent/ATE470436T1/de active
- 2003-11-04 CA CA002471821A patent/CA2471821C/en not_active Expired - Fee Related
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- 2003-11-04 MX MXPA05004859 patent/MX272648B/es active IP Right Grant
- 2003-11-04 CN CNB2003801081294A patent/CN100536828C/zh not_active Expired - Fee Related
- 2003-11-04 KR KR1020057007996A patent/KR101175774B1/ko active IP Right Grant
- 2003-11-04 AU AU2003283101A patent/AU2003283101B2/en not_active Ceased
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103769020A (zh) * | 2014-01-21 | 2014-05-07 | 华南理工大学 | 一种双核微胶囊及其制备方法与应用 |
CN103769020B (zh) * | 2014-01-21 | 2016-03-02 | 华南理工大学 | 一种双核微胶囊及其制备方法与应用 |
Also Published As
Publication number | Publication date |
---|---|
ES2347045T3 (es) | 2010-10-25 |
ATE470436T1 (de) | 2010-06-15 |
AU2003283101A1 (en) | 2004-06-07 |
HK1084054A1 (en) | 2006-07-21 |
CN1731983A (zh) | 2006-02-08 |
JP4833553B2 (ja) | 2011-12-07 |
MXPA05004859A (es) | 2005-12-05 |
US20100092571A1 (en) | 2010-04-15 |
WO2004041251A1 (en) | 2004-05-21 |
DK1575561T3 (da) | 2010-09-20 |
JP2006506410A (ja) | 2006-02-23 |
KR101175774B1 (ko) | 2012-08-21 |
MX272648B (es) | 2009-12-10 |
US8900630B2 (en) | 2014-12-02 |
KR20110112481A (ko) | 2011-10-12 |
DE60332958D1 (de) | 2010-07-22 |
US20110111020A1 (en) | 2011-05-12 |
EP1575561B1 (en) | 2010-06-09 |
BRPI0315977B8 (pt) | 2021-05-25 |
CA2471821A1 (en) | 2004-05-21 |
US20050067726A1 (en) | 2005-03-31 |
EP1575561A1 (en) | 2005-09-21 |
KR20050084683A (ko) | 2005-08-26 |
AU2003283101B2 (en) | 2008-12-11 |
BR0315977A (pt) | 2005-09-20 |
NZ539777A (en) | 2008-02-29 |
BRPI0315977B1 (pt) | 2018-04-03 |
CA2471821C (en) | 2006-04-25 |
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