CN100471468C - Occlusive device for treating septal defect of congenital heart disease - Google Patents
Occlusive device for treating septal defect of congenital heart disease Download PDFInfo
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- CN100471468C CN100471468C CNB2006100544167A CN200610054416A CN100471468C CN 100471468 C CN100471468 C CN 100471468C CN B2006100544167 A CNB2006100544167 A CN B2006100544167A CN 200610054416 A CN200610054416 A CN 200610054416A CN 100471468 C CN100471468 C CN 100471468C
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- heart disease
- congenital heart
- septal defect
- occlusive device
- treating septal
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Abstract
The invention relates the congenital heart disease plugging device, comprising the bevel support 1 and polyester fibre 2. The bevel support 1 is weaved by the nickel-cemented tantalum carbide, and the diameter of 1 is between 0.002-0.003 inch, the 1 is filled with 2, and around the metal wire of 1 there is polydactyl acid, silica gel, polyurethane or other degradable consistency high polymer materials. The invention has the advantages of reducing heavy metal toxicity, low vessel chronic injury and mechanical stimulation, and safety.
Description
Technical field
The invention belongs to technical field of medical instruments, specifically, relate to a kind of plugging device that is used for the treatment of patent ductus arteriosus and congenital heart diseases such as interventricular septum or atrial septal defect.
Background technology
Patent ductus arteriosus (PDA), atrial septal defect (ASD) and ventricular septal defect (VSD) are the common congenital heart diseases of children's, and the three accounts for 80% of whole congenital heart disease.Before the seventies, block up and close main dependence surgical operation; The mid-1970s, people begin to have designed and tried out the new non-breast of opening and close the method for ductus arteriosus and atrial septal defect and succeed, over more than 20 year, successively have the multiple stifled device that closes to try out in animal and clinical trial and obtained very big success, the stifled device that closes commonly used clinically at present both at home and abroad has five kinds of Portsman, Rashkind, Sideris, Coil and Amplatzer etc.Amplatzer Occluder is the up-to-date stifled device that closes of PDA, ASD, VSD, equaling design in 1997 by Amplatzer finishes, should stifled close the advantage that device has been concentrated former device, it expands into mushroom-shaped or double plate umbrella shape after being installed to the lesions position of heart automatically, this device is formed by superfine nitinol alloy wire braiding, the middle polyester fiber of filling.Technically, mushroom-shaped or double plate umbrella shape stifled close device operate compare with other device easier, be subjected to clinician's welcome, but because tenor is excessive, and metal directly contacts with body, metal long-term toxic and side effects in vivo is difficult to determine, metal chronic injury and the mechanical irritation that causes easily blood vessel really up to the mark, thereby cause side effect such as long-term cardiac insufficiency, arrhythmia, so Amplatzer is stifled to be closed device and not to obtain the U.S. FDA identification always, do not generally acknowledged by the world that its application is very limited.
Summary of the invention
It is minimum that the problem to be solved in the present invention provides a kind of toxic and side effects, uses safer occlusive device for treating septal defect of congenital heart disease.
For addressing the above problem, occlusive device for treating septal defect of congenital heart disease of the present invention, comprise the mushroom-shaped or the double plate umbrella stull of being worked out by metal gauze, be filled with polyester fiber in the support, the tinsel of support is coated with one deck degradable biocompatibility macromolecule material.
Owing to outside the tinsel of support, coated one deck degradable biocompatibility macromolecule material, the degradable biocompatibility macromolecule material is contacted with body tissue, avoided tinsel damage and the stimulation that causes really up to the mark to body, macromolecular material is isolated tinsel and tissue, thereby the toxicity of having isolated metal itself reduces even has stopped plugging device secular toxic and side effects in vivo fully.The existence of metal rack has guaranteed the mechanical strength of plugging device again.
As preference, the tinsel of above-mentioned support is preferably nitinol alloy wire, and this Nitinol filament diameter is between 0.002～0.003 cun.Nitinol is a kind of shape memory alloy, has elastic performance, and the fatigue durability of Nitinol and corrosion resistance also are better than rustless steel.Adopting nitinol alloy wire is interior support, draws its diameter little and reduce the content of nitinol alloy wire in whole device as far as possible under the prerequisite that guarantees entire bracket intensity, to reduce the toxic and side effects of metal as much as possible.
As preference, above-mentioned degradable biocompatibility macromolecule material adopts existing polylactic acid or modified silica-gel or modified polyurethane through modification.By the modification of material, strengthen elasticity, the toughness of degradable biocompatibility macromolecule materials such as polylactic acid, silica gel or polyurethane and be controlled at intravital degradation time.
The present invention shows through animal experiment, compare with traditional occlusive device for treating septal defect of congenital heart disease, its metallic poison side effect reduces greatly, and is in the extreme little to the chronic injury and the mechanical irritation of blood vessel, a routine patient do not occur and cardiac insufficiency and ARR side effect occur.
Description of drawings
Below in conjunction with the drawings and specific embodiments the present invention is described in further detail.
Fig. 1 is the structural representation of the embodiment of the invention.
Fig. 2 is that the A of Fig. 1 is to view.
Fig. 3 is the schematic cross-sectional view (amplification) of nitinol alloy wire among Fig. 1.
The specific embodiment
Fig. 1 to Fig. 3 is that the present invention is used as the stifled embodiment that closes of ventricular septal defect (VSD), the support 1 of being worked out by the nickel-cemented alloy filament net of diameter between 0.002～0.003 cun is the double plate umbrella shape, be filled with polyester fiber 2 in the support 1, the tinsel of support 1 is coated with one deck degradable biocompatibility macromolecule material 3, can directly to adopt publication number be CN1435438 to this degradable biocompatibility macromolecule material 3 among this embodiment, the modified polylactic acid material that was provided in the Chinese invention patent prospectus on August 13rd, 2003 in open day.Nitinol alloy wire is as interior support, its diameter is littler than the wire diameter of conventional apparatus, in the making under the prerequisite that guarantees entire bracket intensity, the diameter of nitinol alloy wire can draw smallerly as far as possible, nickel-cemented alloy filament net is also worked out rarelyr as far as possible, and to reduce the content of metal in whole device as much as possible, Nitinol is a kind of shape memory alloy, have elastic performance, the fatigue durability of Nitinol and corrosion resistance also are better than rustless steel.Degradable biocompatibility macromolecule materials such as polydactyl acid contact with body tissue, avoided tinsel damage and the stimulation that causes really up to the mark to body, the polymer modification polylactic acid is isolated tinsel and tissue, thereby the toxicity of having isolated metal itself reduces even has stopped plugging device secular toxic and side effects in vivo fully.By the modification of material, strengthened elasticity, the toughness of degradable biocompatibility macromolecule materials such as polylactic acid and be controlled at intravital degradation time.
Medium-height trestle 1 of the present invention also can be made into mushroom-shaped, as treatment patent ductus arteriosus type congenital heart disease.Also can be made into other shape as required.Degradable biocompatibility macromolecule material 3 can adopt modified silica-gel, also can adopt modified polyurethane, and the occlusive device for treating septal defect of congenital heart disease of producing can reach extraordinary effect equally.
Claims (3)
1, a kind of occlusive device for treating septal defect of congenital heart disease, comprise the mushroom-shaped or the double plate umbrella stull (1) of working out by metal gauze, be filled with polyester fiber (2) in the support (1), it is characterized in that: the tinsel of described support (1) is coated with one deck degradable biocompatibility macromolecule material (3).
2, occlusive device for treating septal defect of congenital heart disease according to claim 1 is characterized in that: the tinsel of described support (1) is a nitinol alloy wire, and the diameter of this nitinol alloy wire is between 0.002～0.003 cun.
3, occlusive device for treating septal defect of congenital heart disease according to claim 1 and 2 is characterized in that: described degradable biocompatibility macromolecule material (3) is polydactyl acid or modified silica-gel or modified polyurethane.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100544167A CN100471468C (en) | 2006-07-06 | 2006-07-06 | Occlusive device for treating septal defect of congenital heart disease |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100544167A CN100471468C (en) | 2006-07-06 | 2006-07-06 | Occlusive device for treating septal defect of congenital heart disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1875894A CN1875894A (en) | 2006-12-13 |
| CN100471468C true CN100471468C (en) | 2009-03-25 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2006100544167A Expired - Fee Related CN100471468C (en) | 2006-07-06 | 2006-07-06 | Occlusive device for treating septal defect of congenital heart disease |
Country Status (1)
| Country | Link |
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| CN (1) | CN100471468C (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102697528B (en) * | 2012-06-01 | 2014-02-26 | 姬尚义 | Closure device |
| CN102805673A (en) * | 2012-08-15 | 2012-12-05 | 上海形状记忆合金材料有限公司 | Occluder |
| US20160345943A1 (en) * | 2014-04-30 | 2016-12-01 | Lepu Medical Technology (Beijing) Co., Ltd | Medical closure system |
| CN107095701A (en) * | 2017-05-23 | 2017-08-29 | 上海英诺伟医疗器械有限公司 | A kind of closure basket and the plugging device with the basket |
| CN110313945B (en) * | 2018-03-28 | 2021-09-28 | 上海微创医疗器械（集团）有限公司 | Plugging device and preparation method thereof |
| CN114495669B (en) * | 2022-02-17 | 2022-10-28 | 北京理工大学 | Composite material for bionic visceral organ |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1283973A (en) * | 1998-02-06 | 2001-02-14 | Aga医药有限公司 | Percutaneous catheter directed constricting occlusion device |
| US20040220610A1 (en) * | 1999-11-08 | 2004-11-04 | Kreidler Marc S. | Thin film composite lamination |
| WO2006105008A1 (en) * | 2005-03-25 | 2006-10-05 | Ample Medical, Inc. | Device, systems, and methods for reshaping a heart valve annulus |
-
2006
- 2006-07-06 CN CNB2006100544167A patent/CN100471468C/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1283973A (en) * | 1998-02-06 | 2001-02-14 | Aga医药有限公司 | Percutaneous catheter directed constricting occlusion device |
| US20040220610A1 (en) * | 1999-11-08 | 2004-11-04 | Kreidler Marc S. | Thin film composite lamination |
| WO2006105008A1 (en) * | 2005-03-25 | 2006-10-05 | Ample Medical, Inc. | Device, systems, and methods for reshaping a heart valve annulus |
Non-Patent Citations (4)
| Title |
|---|
| Catheter closure of perimembranous ventricular septal defectsusing the new Amplatzer membranous VSD occluder: initialclinical experience. Hijazi ZM, Hakim F, Haweleh AA, Madani A, Tarawna W,Hiari A, Cao QL.Catheter Cardiovasc Interv.,Vol.56 No.4. 2002 |
| Catheter closure of perimembranous ventricular septal defectsusing the new Amplatzer membranous VSD occluder: initialclinical experience. Hijazi ZM, Hakim F, Haweleh AA, Madani A, Tarawna W,Hiari A, Cao QL.Catheter Cardiovasc Interv.,Vol.56 No.4. 2002 * |
| Initial human experience with the Amplatzer perimembranousventricular septal occluder device. Bass JL, Kalra GS, Arora R, Masura J, Gavora P,Thanopoulos BD, Torres W, Sievert H, Carminati M, FischerG, Ewert P.Catheter Cardiovasc Interv.,Vol.58 No.2. 2003 |
| Initial human experience with the Amplatzer perimembranousventricular septal occluder device. Bass JL, Kalra GS, Arora R, Masura J, Gavora P,Thanopoulos BD, Torres W, Sievert H, Carminati M, FischerG, Ewert P.Catheter Cardiovasc Interv.,Vol.58 No.2. 2003 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1875894A (en) | 2006-12-13 |
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Application publication date: 20061213 Assignee: Chongqing Nanfang Numerical Control Equipment Co., Ltd. Assignor: He Jianfeng Contract record no.: 2010500000018 Denomination of invention: Occlusive device for treating septal defect of congenital heart disease Granted publication date: 20090325 License type: Exclusive License Record date: 20100416 |
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| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20090325 Termination date: 20130706 |