CN100431626C - Catheter for intraperitoneal chemotherapy - Google Patents
Catheter for intraperitoneal chemotherapy Download PDFInfo
- Publication number
- CN100431626C CN100431626C CNB2006101235902A CN200610123590A CN100431626C CN 100431626 C CN100431626 C CN 100431626C CN B2006101235902 A CNB2006101235902 A CN B2006101235902A CN 200610123590 A CN200610123590 A CN 200610123590A CN 100431626 C CN100431626 C CN 100431626C
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- Prior art keywords
- catheter
- intraperitoneal chemotherapy
- silicone rubber
- conduit
- fluoropolymer
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Abstract
The invention relates to an abdominal cavity chemotherapy duct, wherein it is made from silicon rubber and fluorine polymer; said silicon rubber and fluorine polymer are mixed, while the polymer content is 3-30%; or the side wall of duct is divided into three layers while inner and outer layers are fluorine polymer, and the middle layer is silicon rubber. The inventive duct has high flexibility, better physiological inert, while it will not adhere blood, etc.
Description
Technical field
The present invention relates to a kind of catheter, relate in particular to a kind of catheter for intraperitoneal chemotherapy.
Background technology
The patient is when carrying out intraperitoneal chemotherapy, and catheter for intraperitoneal chemotherapy is that long-term implantation is Intraabdominal, and the present catheter for intraperitoneal chemotherapy of using clinically mainly contains two kinds of material preparations and forms: silicone rubber or politef.Silicone rubber has good physiology inertia, better elastic and contour machining procedure performance, but sticks blood, pus easily, and pipeline blockage usually appears in the catheter for intraperitoneal chemotherapy that is prepared from silicone rubber, medicinal liquid pours into phenomenons such as not smooth; Though and be difficult for sticking blood, pus with the catheter for intraperitoneal chemotherapy that politef is prepared from, but it is hard that shortcoming is a pipe shaft, process industrial art performance is poor, in the clinical use, be difficult to sutured, appearance displacement slippage, and hard tip easily easily causes soft tissue injury, has increased patient's misery.So the basic demand of the ideal catheter for intraperitoneal chemotherapy of performance is as follows: high pliability, well transparent, good processing and forming technology, good physiology inertia, blood, pus are difficult to adhesion.
Summary of the invention
The present invention is in order to overcome the deficiency that above prior art exists, and a kind of high flexible resilient, well processed moulding process, good physiology inertia is provided, has been difficult for sticking the catheter for intraperitoneal chemotherapy of blood, pus.
Purpose of the present invention realizes by following technical scheme: the sidewall of catheter for intraperitoneal chemotherapy divides three layers, and internal layer and skin are fluoropolymer, and the intermediate layer is a silicone rubber.
The thickness of described internal layer or outer fluoropolymer is 1～50 μ m, and the thickness of intermediate layer silicone rubber is 500～2000 μ m.
Described fluoropolymer is any or its analog in politef, Kynoar, tetrafluoroethene and perfluoroethylene copolymer, fluorothene and ethylene copolymer, the silicon-fluorine polymer thing.
Described silicone rubber is vinylsiloxane rubber.
Described conduit the inner is involuted by two sphere shape tablets along the catheter body longitudinal extension, forms one arc opening between two tablets, is fish mouth shape.
Be distributed with a plurality of side openings on the described duct wall, each side opening has a limit fluid can only flow to check valve outside the conduit in conduit.
Described check valve is a lamellar, is covered on the corresponding side opening; Check valve is connected with conduit outer wall near a side of catheter body outer end.
The present invention has following advantage with respect to prior art: this novel catheter for intraperitoneal chemotherapy adopts silicone rubber and fluorinated polymer material to make silicone rubber and fluoropolymer blend; Perhaps duct wall divides three layers, internal layer and skin are fluoropolymer, the intermediate layer is a silicone rubber, two kinds of catheter for intraperitoneal chemotherapy of above-mentioned preparation had both had the high flexible resilient of silicone rubber, good extruding-out process performance, good physiology inertia, have politef again and do not stick dirts such as blood, pus, the characteristic that perfusion is smooth, this novel catheter for intraperitoneal chemotherapy has very high serviceability, has alleviated patient's misery.
Description of drawings
Fig. 1 is that internal layer and skin are fluoropolymer, and the intermediate layer is the local longitudinal sectional view of the catheter for intraperitoneal chemotherapy of silicone rubber.
Fig. 2 is the local longitudinal sectional view of the catheter for intraperitoneal chemotherapy of silicone rubber and fluoropolymer blend.
Fig. 3 is the longitudinal sectional view of a kind of catheter for intraperitoneal chemotherapy of the present invention.
The specific embodiment
The present invention is further described below in conjunction with drawings and Examples.
Fig. 1 shows a preferred embodiment of the present invention, this catheter for intraperitoneal chemotherapy 1 adopts silicone rubber 2 and fluoropolymer 3 preparations, described duct wall divides three layers, internal layer and skin all are made of fluoropolymer 3, the intermediate layer is made of silicone rubber 2, the thickness of described internal layer or outer fluoropolymer is 1～50 μ m, the thickness of intermediate layer silicone rubber is 500～2000 μ m, described fluoropolymer 3 comprises politef, Kynoar, tetrafluoroethene and perfluoroethylene copolymer, fluorothene and ethylene copolymer, silicon-fluorine polymer thing or its analog, described silicone rubber 2 is vinylsiloxane rubber, and vinylsiloxane rubber can adopt peroxide vulcanizing system or adopt the addition vulcanization system.
Provide two kinds of concrete schemes below:
Scheme 1:
Internal layer, skin: 4 μ m powder PTFE (politef), Minnesota Mining and Manufacturing Company;
Intermediate layer: BASE50 silicone rubber, Hae Ryong Silicone Co.Ltd.Kotea
Catheter diameter: 2000 μ m;
The tube wall gross thickness: 1520 μ m, wherein ectonexine thickness is 10 μ m, and intermediate layer thickness is 1500 μ m.
Scheme 2:
Internal layer, skin: Dyneon 4-8 μ m PTFE (politef), Minnesota Mining and Manufacturing Company;
Intermediate layer: Dow Corning C6-150 silicone rubber, Dow Corning Co.Ltd.;
Catheter diameter: 1500 μ m;
The tube wall gross thickness: 1200 μ m, wherein ectonexine thickness is 15 μ m, and intermediate layer thickness is 1170 μ m.
Embodiment 2
The catheter for intraperitoneal chemotherapy 1 of Fig. 2 adopts mechanical blending to become intermingling material 4, extrusion molding then by silicone rubber and fluoropolymer.Wherein the quality of fluoropolymer accounts for 3～30%.
No matter be the catheter for intraperitoneal chemotherapy 1 of Fig. 1, adopt silicone rubber 2 and fluoropolymer three layers of preparation in 3 fens, or the catheter for intraperitoneal chemotherapy 1 of Fig. 2, adopt intermingling material 4 preparations of silicone rubber and fluoropolymer, all have the high flexible resilient of silastic material, good extruding-out process performance, good physiology inertia, have politef again and do not stick dirts such as blood, pus, the characteristic that perfusion is smooth, Zhi Bei catheter for intraperitoneal chemotherapy has very high serviceability like this, has alleviated patient's misery.
Embodiment 3
Fig. 3 shows the preferred structure of a kind of catheter for intraperitoneal chemotherapy of the present invention, this catheter for intraperitoneal chemotherapy comprises catheter body 1, described catheter body 1 the inner is involuted by two sphere shape tablets 5 along the catheter body longitudinal extension, form one arc opening 6 between two tablets 5, be fish mouth shape, be distributed with a plurality of side openings 7 on described catheter body 1 sidewall, each side opening 7 has a limit fluid can only flow to check valve 8 outside the conduit in conduit, described check valve 8 is a lamellar, is covered on the corresponding side opening 7; Check valve 8 is connected with conduit outer wall near a side 9 of catheter body 1 outer end, the axis of described arbitrary side opening 7 favours duct wall, outlet deflection catheter body 1 outer end of side opening 7, described side opening 7 is two row and is arranged on the two side relative on the conduit, the axis of two row side openings 7 coexists on the plane, the plane at this plane and described arc opening 6 places is perpendicular, and described two row side openings 7 are upwards arranged at catheter shaft highly staggeredly.
When the infusion medicinal liquid, sphere shape tablet 5 and check valve 8 open automatically, and medicinal liquid is flowed out smoothly, because medicinal liquid is from a plurality of local outflows, the diffusion of medicinal liquid is better, after the medicinal liquid infusion was finished, under conduit self material elastic reaction, sphere shape tablet 5 was closed under the active force around automatically, check valve 8 is auto-closing under the active force outside pipe also, thereby stop blood and other body fluid to enter in the tube chamber, avoid the plugging phenomenon to take place, also need not the injecting heparin normal saline.
The above-mentioned specific embodiment is the preferred embodiments of the present invention; can not limit claim of the present invention; other any change or other equivalent substitute mode that does not deviate from technical scheme of the present invention and made is included within protection scope of the present invention.
Claims (7)
1, a kind of catheter for intraperitoneal chemotherapy is characterized in that: duct wall divides three layers, and internal layer and skin are fluoropolymer, and the intermediate layer is a silicone rubber.
2, catheter for intraperitoneal chemotherapy according to claim 1 is characterized in that: the thickness of described internal layer or outer fluoropolymer is 1～50 μ m, and the thickness of intermediate layer silicone rubber is 500～2000 μ m.
3, catheter for intraperitoneal chemotherapy according to claim 1 and 2 is characterized in that: described fluoropolymer is any in politef, Kynoar, tetrafluoroethene and perfluoroethylene copolymer, fluorothene and ethylene copolymer or the silicon-fluorine polymer thing.
4, catheter for intraperitoneal chemotherapy according to claim 1 and 2 is characterized in that: described silicone rubber is vinylsiloxane rubber.
5, catheter for intraperitoneal chemotherapy according to claim 1 and 2 is characterized in that: described conduit the inner is involuted by two sphere shape tablets along the catheter body longitudinal extension, forms one arc opening between two tablets, is fish mouth shape.
6, catheter for intraperitoneal chemotherapy according to claim 5 is characterized in that: be distributed with a plurality of side openings on the described duct wall, each side opening has a limit fluid can only flow to check valve outside the conduit in conduit.
7, catheter for intraperitoneal chemotherapy according to claim 6 is characterized in that: described check valve is a lamellar, is covered on the corresponding side opening; Check valve is connected with conduit outer wall near a side of catheter body outer end.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006101235902A CN100431626C (en) | 2006-11-16 | 2006-11-16 | Catheter for intraperitoneal chemotherapy |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006101235902A CN100431626C (en) | 2006-11-16 | 2006-11-16 | Catheter for intraperitoneal chemotherapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1966096A CN1966096A (en) | 2007-05-23 |
| CN100431626C true CN100431626C (en) | 2008-11-12 |
Family
ID=38075187
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2006101235902A Expired - Fee Related CN100431626C (en) | 2006-11-16 | 2006-11-16 | Catheter for intraperitoneal chemotherapy |
Country Status (1)
| Country | Link |
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| CN (1) | CN100431626C (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4536179A (en) * | 1982-09-24 | 1985-08-20 | University Of Minnesota | Implantable catheters with non-adherent contacting polymer surfaces |
| CN2041572U (en) * | 1988-10-14 | 1989-07-26 | 上海市房产局职工医院 | Embedded perfusion device for arteria chemotherapy |
| JPH0341966A (en) * | 1989-07-10 | 1991-02-22 | Terumo Corp | Guide wire |
| CN2139829Y (en) * | 1992-07-25 | 1993-08-11 | 施兆发 | Drainage tube with mini-hole |
| JP3041966B2 (en) * | 1990-12-28 | 2000-05-15 | オムロン株式会社 | Voltage adjustment relay device |
| US6368315B1 (en) * | 1999-06-23 | 2002-04-09 | Durect Corporation | Composite drug delivery catheter |
-
2006
- 2006-11-16 CN CNB2006101235902A patent/CN100431626C/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4536179A (en) * | 1982-09-24 | 1985-08-20 | University Of Minnesota | Implantable catheters with non-adherent contacting polymer surfaces |
| CN2041572U (en) * | 1988-10-14 | 1989-07-26 | 上海市房产局职工医院 | Embedded perfusion device for arteria chemotherapy |
| JPH0341966A (en) * | 1989-07-10 | 1991-02-22 | Terumo Corp | Guide wire |
| JP3041966B2 (en) * | 1990-12-28 | 2000-05-15 | オムロン株式会社 | Voltage adjustment relay device |
| CN2139829Y (en) * | 1992-07-25 | 1993-08-11 | 施兆发 | Drainage tube with mini-hole |
| US6368315B1 (en) * | 1999-06-23 | 2002-04-09 | Durect Corporation | Composite drug delivery catheter |
Non-Patent Citations (2)
| Title |
|---|
| 多功能腹腔化疗管动物安全性评价. 曹明溶，牟善松.广东医学，第26卷第7期. 2005 |
| 多功能腹腔化疗管动物安全性评价. 曹明溶，牟善松.广东医学，第26卷第7期. 2005 * |
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| Publication number | Publication date |
|---|---|
| CN1966096A (en) | 2007-05-23 |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20081112 Termination date: 20121116 |