CN100427044C - Artificial blood vessel - Google Patents
Artificial blood vessel Download PDFInfo
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- CN100427044C CN100427044C CNB2006100541347A CN200610054134A CN100427044C CN 100427044 C CN100427044 C CN 100427044C CN B2006100541347 A CNB2006100541347 A CN B2006100541347A CN 200610054134 A CN200610054134 A CN 200610054134A CN 100427044 C CN100427044 C CN 100427044C
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- blood vessel
- artificial blood
- wall
- vessel
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Abstract
The present invention provides an artificial blood vessel. A spiral groove is arranged in the vessel inner wall of the artificial blood vessel, the spiral groove extends at an inner wall along a spiral line, and the cross section of the spiral groove is in a circular arc. Flow field distribution in the artificial blood vessel with a small diameter is changed by the geometry of the inner surface of the inner wall, and the blood flow speed of the artificial blood vessel is newly distributed. Blood flow speed near a wall surface is increased, and the wall of the artificial blood vessel is flushed. The shearing force of the flow wall surface in the artificial blood vessel is enhanced as much as possible on the premise of a certain physiological blood flow, the deposition of harmful substances in blood at a vessel wall is reduced, and the purpose that the long-term smooth rate of the artificial blood vessel and particularly the artificial blood vessel with a small diameter is enhanced is achieved. The present invention provides an important solution approach for the problem of the embolism failure of the artificial blood vessel with a small diameter, which is not solved for a long time.
Description
Technical field
The present invention relates to a kind of artificial blood vessel structure.
Background technology
Blood vessel transplantation is applied to bypass surgery and artery reconstruction has had 50 history.Although heavy caliber blood vessel transplantation has obtained immense success clinically, but small-bore (＜5-6mm) the blood vessel transplantation clinical problem is not resolved yet, because thrombosis and endotheliosis from body blood vessel finite sum synthetic vessel lead to the failure, always the wait in expectation breakthrough of small-caliber artificial blood vessel and in the bypass surgery of heart and peripheral circulation, be in the wilderness demand state of people.
For solving small-bore artificial blood vessel patency rate, the main both at home and abroad dual mode that adopts: 1) timbering material is selected and optimized.2) material surface is carried out surface treatment and modification.The starting point that more than solves the artificial blood vessel patency rate all be introduce again foreign material or by external medicine be used for suppress that thereby the formation of thrombosis reaches the effect that improves patency rate in the blood vessel.Though certain effect is arranged, but also introduced new problem when solving original problem: 1) after the high molecular degradable material degraded, timbering material is exposed in the blood again will face the problem that may cause thrombosis again; 2) coated medicine and cell cause timbering material newly to be exposed in the blood because of too early the coming off of the pressure that can't bear physiological environment.
Summary of the invention
The objective of the invention is to deficiency at the prior art existence, a kind of artificial blood vessel with particular geometries is proposed, by the geometry that changes the blood vessel wall inner surface blood flow is changed, improve small-bore artificial blood vessel inwall blood flow rate, to reduce in the blood tangible element and harmful substance in the deposition of artificial blood tube wall.
This small-bore artificial blood vessel research is the patency rate that the hemodynamic principle of utilization is improved artificial blood vessel.Hemodynamics Study finds that the blood flow at ascending aorta place is the binary vortices fluidised form.Aortic arch is as a umbrella handle, and its bending is to be the space three-dimensional helical form.The configuration of this space three-dimensional spiral just, it is moving to make that the blood flow at ascending aorta place is binary vortices.The turn of aortic arch place blood flow is the design of the Nature wonderful workmanship excelling nature, and being that the ascending aorta vascular wall is smooth washes away in case the assurance that the stop pulse atherosclerosis forms.Based on above-mentioned principle, the present invention proposes following technical scheme: at the inside pipe wall of artificial blood vessel design helicla flute, helicla flute along helix in inner wall extend, vessel diameter 0＜d≤6mm wherein, spiral groove depth 0＜h≤1mm, helix pitch is 0＜m≤3mm.Groove depth h is the distance from the mid point of the string of helicla flute section circular arc to the mid point of circular arc.
By above-mentioned design, can change the Flow Field Distribution in the small-bore artificial blood vessel, blood vessel speed is redistributed, increase near the blood flow rate of wall, cause washing away of artificial blood tube wall, under the certain prerequisite of physiology blood flow, improve the mobile boundary shear stress in the artificial blood vessel as much as possible, thereby provide effective measures for solving the acute thromboembolism of small-bore artificial blood vessel this problem that is outstanding for a long time that lost efficacy.
Description of drawings
Fig. 1 is the axial section of blood vessel;
Fig. 2 is the radial section figure of blood vessel.
Wherein, L: pipe range, D: external diameter, d: internal diameter, h: groove depth, m: helix pitch
The specific embodiment
Below be the design process of artificial blood vessel:
1. adopt the mechanical assistance design software to make up geometric model, calculate the flow field, improved near the parameter of the model of the speed of wall preferably with the Fluid Mechanics Computation software simulation:
Adopt mechanical assistance design software solid works to make up a series of geometric models, with cfdrc PHOENICS analog computation flow field, with the velocity field is that index is carried out parameter optimization, and fluid parameter is taken from transparent organic solvent wintergreen oil, and density is 1182kgm
-3, viscosity is 0.216gm
-1S
-1To the pipe range of helix barrel, the spiral distance, three factors of groove depth are carried out orthogonal design.Pipe range has 120mm, 80mm, and three levels of 60mm, the spiral distance has 2mm, 4mm, three levels of 6mm, groove depth has 0.2mm, 0.4mm, three levels of 0.6mm.The helix barrel of corresponding three different pipe ranges has the control tube with length respectively, and the design conditions of two pipes are identical.The porch is provided with constant flow, and the flow size is by flow velocity 2.4ms
-1The area that multiply by inlet calibre obtains.In the Cartesian coordinate system, flowing is set to time dependent stable flowing.Computation model is as follows: the Elliptic-Staggered equation, and one phase flow is found the solution speed and pressure, and perturbation mode is KEMODL, and mobile main body is the water under 20 ℃.Iterative computation 200 times.Obtain a geometric model that improves near the speed of wall preferably, as shown in Figure 1, at the inside pipe wall of blood vessel body 1 design helicla flute 2, also can be the helix structure of projection, helicla flute along helix in inner wall extend, the section of helicla flute 2 is one 120 ° a circular arc, the helix groove length of tube is L=120mm, groove depth h=0.6mm, inner diameter d=6mm, outer diameter D=12mm, helix pitch m=2mm contrast the plain tube pipe range accordingly and are 120mm.
2. use the speed of Fluid Mechanics Computation computed in software plain tube and helix barrel:
Utilize the speed of PHOENICS calculating plain tube and helix barrel, chose the cross section in axle center, obtain corresponding speed sketch map.Near the axle center speed plain tube is bigger, and plain tube reduces slowly than helix barrel.Because two tube inlet place flows are identical, the helix barrel has less axis speed, and a part of flow of the difference explanation helix barrel distributing shaft heart is to fluidic periphery---the inwall place of pipe so, and speed helix barrel is greater than plain tube near the tube wall.
3. contrast plain tube, the influence of computational analysis helix groove stream field, the checking helix groove can improve the conclusion of artificial blood vessel wall speed.The contrast plain tube, the influence of computational analysis helix groove stream field, the checking helix groove can improve the conclusion of artificial blood vessel wall speed:
Fixing Y value in coordinate system obtains the section by axle, again by changing the X value, obtains the straight line with the inwall different distance, and the Z value represents that certain puts the distance between two points of the point at straight line upper inlet place therewith on the straight line.Except 2 points in porch and exit, on straight line, from the porch to the exit, select 14 points again by average distance, therefore have 16 sampling points on every straight line.Show the velocity amplitude that obtains these points by the software middle probe.By the speed of the point on the corresponding straight line that contrasts two pipes, obtain the contrast of each spot speed of plain tube and helix barrel.
By calculating the meansigma methods of speed on each straight line, the contrast control tube can quantize the amplitude that the comparison of helix barrel increases according to speed.Because every straight line upper outlet and porch 2 are very big with other 14 difference, so every straight line is got other 14 calculating mean values of removing 2 of entrance and exits.Two pipe line correspondences are compared then, obtain corresponding data form and analysis diagram.At the inwall place, the helix barrel is 224.0% of a plain tube, and to locate the former be the latter's 95.1% in the axle center.
Remove 14 the speed average of ingress and egress point and the ratio of two pipes on each straight line of table two pipe
Show that by contrast smooth inner wall pipe near the speed in the helix barrel inwall increases, near the speed the axle center reduces, and speed is redistributed.Reached the purpose that reduces particle dead time and wash away tube wall by near the speed the increase inwall.
4. by the determined geometry of optimal design, utilize pmma material to be machined into the artificial blood vessel mock-up.The access of artificial blood vessel mock-up is circulated flow field research, and the result of calculation of checking numerical simulation is correct:
By the determined geometry of optimal design, utilize pmma material to be machined into the artificial blood vessel mock-up.The access of artificial blood vessel mock-up is circulated flow field research, see whether the flow field reaches designing requirement.Adopt particle image velocimetry technology (PIV) helix barrel and contrast plain tube are carried out the flow field experiment and to take pictures, obtain particle mobile difference in the artificial blood vessel model and in the plain tube, the result of calculation of checking numerical simulation is correct.
5, according to every data of the final artificial blood vessel mock-up that obtains, make small-bore artificial blood vessel.
Claims (1)
1, a kind of artificial blood vessel, it has the blood vessel body, it is characterized in that: the inside pipe wall at the blood vessel body has helicla flute, and in inner wall extend, the spiral fluted section is a circular arc to helicla flute along helix; Internal diameter 0＜d≤the 6mm of its medium vessels, spiral groove depth 0＜h≤1mm, helix pitch is 0＜m≤3mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100541347A CN100427044C (en) | 2006-03-14 | 2006-03-14 | Artificial blood vessel |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100541347A CN100427044C (en) | 2006-03-14 | 2006-03-14 | Artificial blood vessel |
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| CN1817328A CN1817328A (en) | 2006-08-16 |
| CN100427044C true CN100427044C (en) | 2008-10-22 |
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| CNB2006100541347A Expired - Fee Related CN100427044C (en) | 2006-03-14 | 2006-03-14 | Artificial blood vessel |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009010898A2 (en) * | 2007-07-13 | 2009-01-22 | Koninklijke Philips Electronics N.V. | Phantom for ultrasound guided needle insertion and method for making the phantom |
| CN101385667B (en) * | 2008-09-24 | 2011-05-04 | 北京航空航天大学 | Artificial blood vessel with bias current guide |
| CN102266255B (en) * | 2011-05-17 | 2013-07-10 | 东华大学 | Electrostatic spinning production method of conical corrugated small-caliber artificial blood vessel |
| CN104398316A (en) * | 2014-11-25 | 2015-03-11 | 北京航空航天大学 | Tapered spiral small-diameter artificial blood vessel capable of generating swirl flow |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6514284B1 (en) * | 2000-04-20 | 2003-02-04 | Advanced Cardiovascular Systems, Inc. | Stent having inner flow channels |
| CN2564131Y (en) * | 2002-08-16 | 2003-08-06 | 邓小燕 | Small diameter vortex guiding artificial blood vessel |
| CN2564118Y (en) * | 2002-08-16 | 2003-08-06 | 邓小燕 | Vortex lead cavity vein filter |
| US20040079428A1 (en) * | 2000-12-14 | 2004-04-29 | Houston Graeme J. | Fluid flow in tubing |
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2006
- 2006-03-14 CN CNB2006100541347A patent/CN100427044C/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6514284B1 (en) * | 2000-04-20 | 2003-02-04 | Advanced Cardiovascular Systems, Inc. | Stent having inner flow channels |
| US20040079428A1 (en) * | 2000-12-14 | 2004-04-29 | Houston Graeme J. | Fluid flow in tubing |
| CN2564131Y (en) * | 2002-08-16 | 2003-08-06 | 邓小燕 | Small diameter vortex guiding artificial blood vessel |
| CN2564118Y (en) * | 2002-08-16 | 2003-08-06 | 邓小燕 | Vortex lead cavity vein filter |
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| CN1817328A (en) | 2006-08-16 |
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Granted publication date: 20081022 Termination date: 20110314 |