CA2762072A1 - Devices, systems, and methods for medicament delivery - Google Patents
Devices, systems, and methods for medicament delivery Download PDFInfo
- Publication number
- CA2762072A1 CA2762072A1 CA2762072A CA2762072A CA2762072A1 CA 2762072 A1 CA2762072 A1 CA 2762072A1 CA 2762072 A CA2762072 A CA 2762072A CA 2762072 A CA2762072 A CA 2762072A CA 2762072 A1 CA2762072 A1 CA 2762072A1
- Authority
- CA
- Canada
- Prior art keywords
- medicament
- housing
- output
- needle
- circuit system
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M5/2046—Media being expelled from injector by gas generation, e.g. explosive charge
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M5/2053—Media being expelled from injector by pressurised fluid or vacuum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M5/2066—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically comprising means for injection of two or more media, e.g. by mixing
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
- G16H20/17—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
- G16H40/20—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/2006—Having specific accessories
- A61M2005/2013—Having specific accessories triggering of discharging means by contact of injector with patient body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/2026—Semi-automatic, e.g. user activated piston is assisted by additional source of energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/206—With automatic needle insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/2073—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3128—Incorporating one-way valves, e.g. pressure-relief or non-return valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/10—Tube connectors; Tube couplings
- A61M2039/1083—Tube connectors; Tube couplings having a plurality of female connectors, e.g. Luer connectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/10—Tube connectors; Tube couplings
- A61M2039/1088—Tube connectors; Tube couplings having a plurality of male connectors, e.g. Luer connectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/13—General characteristics of the apparatus with means for the detection of operative contact with patient, e.g. lip sensor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/14—Detection of the presence or absence of a tube, a connector or a container in an apparatus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/18—General characteristics of the apparatus with alarm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/35—Communication
- A61M2205/3576—Communication with non implanted data transmission devices, e.g. using external transmitter or receiver
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
- A61M2205/502—User interfaces, e.g. screens or keyboards
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/582—Means for facilitating use, e.g. by people with impaired vision by tactile feedback
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/60—General characteristics of the apparatus with identification means
- A61M2205/6018—General characteristics of the apparatus with identification means providing set-up signals for the apparatus configuration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/60—General characteristics of the apparatus with identification means
- A61M2205/6036—General characteristics of the apparatus with identification means characterised by physical shape, e.g. array of activating switches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M5/2448—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3202—Devices for protection of the needle before use, e.g. caps
- A61M5/3204—Needle cap remover, i.e. devices to dislodge protection cover from needle or needle hub, e.g. deshielding devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
- A61M5/321—Means for protection against accidental injuries by used needles
- A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
- A61M5/326—Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3287—Accessories for bringing the needle into the body; Automatic needle insertion
Abstract
An apparatus suitable for training a user in the operation of an autoinjector includes a housing, a movable member, an electronic circuit system, a base, and a safety lock. The housing is associated with the autoinjector. The movable member moves within the housing when the apparatus is transitioned from an initial configuration to an activated configuration. The electronic circuit system is coupled to the housing, and includes a first switch and a second switch. The base is configured to move relative to the housing between a first position and a second position, and to actuate the second switch to produce a second instruction. The safety lock engages the movable member and limits movement of the base when the safety lock is coupled to the housing. The safety lock is configured to actuate the first switch when the safety lock is removed from the housing to produce a first instruction.
Description
Devices, Systems, and Methods for Medicament Delivery Cross-References to Related Applications [1] This application claims priority to, and incorporates by reference herein in its entirety, the following pending United States Provisional Patent Applications:
[2] Serial No. 60/648,822 (Attorney Docket No. 1022-0 10), filed 1 February 2005; and
[3] Serial No. 60/731,886 (Attorney Docket No. 1022-021), filed 31 October 2005.
Brief Description of the Drawings
Brief Description of the Drawings
[4] A wide variety of potential embodiments will be more readily understood through the following detailed description of certain exemplary embodiments, with reference to the accompanying exemplary drawings in which:
[5] FIG. 1 is a perspective view of an exemplary embodiment of a system 1000;
[6] FIG. 2 is a front view of an exemplary embodiment of a system 1000;
[7] FIG. 3 is a side view of an exemplary embodiment of a system 1000;
[8] FIG. 4 is a cross-sectional view taken along lines A-A of FIG. 3 of an exemplary embodiment of a system 1000 in a first operative position;
[9] FIG. 5 is a cross-sectional view taken along lines A-A of FIG. 3 of an exemplary embodiment of a system 1000 in a second operative position;
[10] FIG. 6 is a cross-sectional view taken along lines A-A of FIG. 3 of an exemplary embodiment of a system 1000 in a third operative position;
[11] FIG. 7 is a cross-sectional view taken along lines A-A of FIG. 3 of an exemplary embodiment of a system 1000 in a fourth operative position;
[12] FIG. 8 is a cross-sectional view taken along lines A-A of FIG. 3 of an exemplary embodiment of a system 1000 in a fifth operative position;
[13] FIG. 9 is a cross-sectional view taken along lines A-A of FIG. 3 of an exemplary embodiment of a system 1000 in a sixth operative position;
[14] FIG. 10 is a flowchart of an exemplary embodiment of a method 10000;
[15] . FIG. 11 is a perspective view of an exemplary embodiment of system 1000;
[16] FIG. 12 is a perspective cross-sectional view taken along lines B-B of FIG. 11;
[17] FIG. 13 is a perspective view of an exemplary embodiment of actuation stick 2200;
[18] FIG. 14 is a cross-sectional view of an exemplary embodiment of gas venting mechanism 8000 taken along lines A-A of FIG. 3;
[19] FIG. 15 is a cross-sectional view taken along lines A-A of FIG. 3 of an exemplary embodiment of a system 15000;
[20] FIG. 16 is a perspective view of an exemplary embodiment an auto-injector 16000;
[21] FIG. 17 is a cross-sectional view taken along lines A-A of FIG. 3 of an exemplary embodiment of a system 17000;
[22] FIG. 18A is an end view of an exemplary embodiment of a system 18000;
[23] FIG. 18B is a cross-sectional view taken along lines A-A of FIG. 18A
of an exemplary embodiment of a system 18000;
of an exemplary embodiment of a system 18000;
[24] FIG. 19 is a cross-sectional view taken along lines A-A of FIG. 18A of an exemplary embodiment of a system 19000;
[25] FIG. 20 is a cross-sectional view taken along lines A-A of FIG. 18A of an exemplary embodiment of a system 20000;
[26] FIG. 21A is a cross-sectional view taken along lines A-A of FIG. 18A
of an exemplary embodiment of a system 21000;
of an exemplary embodiment of a system 21000;
[27] FIG. 21B is a front view of an exemplary embodiment of a system 21000;
[28] FIG. 22A is a cross-sectional view taken along lines A-A of FIG. 18A
of an exemplary embodiment of a system 22000;
of an exemplary embodiment of a system 22000;
[29] FIG. 22B is a front view of an exemplary embodiment of a system 22500;
[30] FIG. 23 is a perspective view of an exemplary embodiment an auto-injector 23000;
[31] FIG. 23 is a cross-sectional view taken along lines A-A of FIG. 18A of an exemplary embodiment of a system 23000;
[32] FIG. 24 is a perspective view of an exemplary embodiment an auto-injector 24000;
[33] FIG. 25 is a perspective view of an exemplary embodiment an auto-injector 25000; and
[34] FIG. 26 is a block diagram of an exemplary embodiment an information device 26000.
Definitions
Definitions
[35] When the following terms are used substantively herein, the accompanying definitions apply:
[36] a - at least one.
[37] activate - to actuate and/or set in motion and/or action.
[38] activity - an action, act, step, and/or process or portion thereof.
[39] actuating portion - that part that puts something into action.
[40] actuation lock - a device adapted to prevent actuation, such as, for example a pivotable, translatable, keyed, squeezable, and/or removable lock.
[41] actuator - a mechanism that puts something into action.
[42] adapted to - suitable or fit for a particular purpose.
[43] and/or - either in conjunction with or in alternative to.
[44] apparatus - a mechanism and/or device.
[45] arm - an elongated structural member, which need not be solely linear.
[46] auto-injector - device that allows a user to deliver a medicament without having to manually prepare the injection. Exemplary devices include pen delivered injectors, syringes, needleless injectors, gas powered auto-injectors, and/or any other auto-injector and/or medical device used to inject a medicament into a user/patient, etc.
[47] automatically - acting or operating in a manner essentially independent of external influence or control. For example, an automatic light switch can turn on upon "seeing" a person in its view, without the person manually operating the light switch.
[48] axis - a straight line about which a body or geometric object rotates or may be conceived to rotate.
[49] can - is capable of, in at least some embodiments.
[50] channel - a conduit for one or more fluids.
[51] compressed gas - a substantially pressurized substance, such as helium, nitrogen, and/or carbon dioxide, etc., in a gaseous form.
[52] comprising - including but not limited to.
[53] contain - to hold within.
[54] contents - a contained compressed gas.
[55] credit card - a card (usually plastic) that assures a seller that the person using it has a satisfactory credit rating and that the issuer will see to it that the seller receives payment for the merchandise and/or services delivered. Typically measuring in size from approximately 3 to approximately 4 inches in length, such as approximately 3.40 inches, 3.375 inches, 85 millimeters, etc., and from approximately 1.75 to approximately 2.75 inches in width, such as approximately 2.10 inches, 2.2125 inches, 2.5 inches, 55 millimeters, etc.
[56] data - distinct pieces of information, usually formatted in a special or predetermined way and/or organized to express concepts.
[57] define - to establish the outline, form, or structure of.
[58] device - a machine, manufacture, and/or collection thereof.
[59] discharge - to release from confinement; to emit.
[60] driving force - a force sufficient to cause, directly or indirectly, expulsion of an injectable medicament from one or more vials and/or from an auto-injector.
[61] dry substance - a material that is substantially free from liquid or moisture.
[62] eject - to expel.
[63] embedded system - a programmed hardware device comprising a microprocessor controlled by an operating system and/or control logic that is specifically designed for a particular kind of application. The operating system and/or control logic of an embedded system comprises a limited set of pre-defined functions that can not be modified or added to by additional user-installed software, although some embedded systems allow a user to modify values of variables and/or parameters of the pre-defined functions. Exemplary devices that can comprise embedded systems are: medical devices, calculators, automobiles, airplanes, vending machines, toys, programmable logic controllers, appliances, refrigerators, microwave ovens, clothes washers, thermostats, alarm systems, sprinkler systems, lighting controllers, electronic equipment, laser printers, CD players, DVD
players, watches, and/or digital cameras, etc.
players, watches, and/or digital cameras, etc.
[64] escape port - an opening for the exit of a gas.
[65] expulsion - the act of forcibly ejecting a fluid via a designed outlet of a container.
[66] expulsion pressure - a force applied over an area of a liquid, the force sufficient to expel the liquid in a predetermined manner.
[67] extend - to move out and/or away from,
[68] extendable - able to move out and/or away from.
[69] fluid - a gas and/or liquid.
[70] fluidly coupleable - able to be related via a fluid.
[71] force initiator - a source, such as a compressed gas container, spring, and/or chemical reaction, etc., capable of supplying a driving force.
[72] frangible - a device that is capable of being broken and/or penetrated to allow fluid to flow therethrough.
[73] haptic - involving the human sense of kinesthetic movement and/or the human sense of touch. Among the many potential haptic experiences are numerous sensations, body-positional differences in sensations, and time-based changes in sensations that are perceived at least partially in non-visual, non-audible, and non-olfactory manners, including the experiences of tactile touch (being touched), active touch, grasping, pressure, friction, traction, slip, stretch, force, torque, impact, puncture, vibration, motion, acceleration, jerk, pulse, orientation, limb position, gravity, texture, gap, recess, viscosity, pain, itch, moisture, temperature, thermal conductivity, and thermal capacity.
[74] hard real-time - relating to computer systems that provide an absolute deterministic response to an event. Such a response is not based on average event time. Instead, in such computer systems, the deadlines are fixed and the system must guarantee a response within a fixed and well-defined time. Systems operating in hard real-time typically interact at a low level with physical hardware via embedded systems, and can suffer a critical failure if time constraints are violated. A
classic example of a hard real-time computing system is the anti-lock brakes on a car. The hard real-time constraint, or deadline, in this system is the time in which the brakes must be released to prevent the wheel from locking. Another example is a car engine control system, in which a delayed control signal might cause engine failure or damage. Other examples of hard real-time embedded systems include medical systems such as heart pacemakers and industrial process controllers.
[751 hazardous condition - a situation marked by risk, danger, and/or peril.
[76] housing - something that covers, encloses, protects, holds, and/or supports.
[77] in reaction to - responding indirectly and/or directly to.
[78] indicate - to show, mark, signify, denote, evidence, evince, manifest, declare, enunciate, specify, explain, exhibit, present, reveal, disclose, and/or display.
[79] indicator - a device and/or substance that indicates.
[80] information device - any device capable of processing information, such as any general purpose and/or special purpose computer, such as a personal computer, workstation, server, minicomputer, mainframe, supercomputer, computer terminal, laptop, wearable computer, and/or Personal Digital Assistant (PDA), mobile terminal, Bluetooth device, communicator, "smart" phone (such as a Treo-like device), messaging service (e.g., Blackberry) receiver, pager, facsimile, cellular telephone, a traditional telephone, telephonic device, a programmed microprocessor or microcontroller and/or peripheral integrated circuit elements, an ASIC or other integrated circuit, a hardware electronic logic circuit such as a discrete element circuit, and/or a programmable logic device such as a PLD, PLA, FPGA, or PAL, or the like, etc. In general any device on which resides a finite state machine capable of implementing at least a portion of a method, structure, and/or or graphical user interface described herein may be used as an information device. An information device can comprise components such as one or more network interfaces, one or more processors, one or more memories containing instructions, and/or one or more input/output (1/0) devices, one or more user interfaces coupled to an I/O device, etc.
[81) injectable medicament - a medicine, medication, drug, pharmaceutical, prescriptive, agent, antidote, anti-venom, hormone, stimulant, vasodilator, anesthetic, and/or nutritional supplement that is substantially ready for injection.
[82] input/output (I/O) device - any sensory-oriented input and/or output device, such as an audio, visual, haptic, olfactory, and/or taste-oriented device, including, for example, a monitor, display, projector, overhead display, keyboard, keypad, mouse, trackball, joystick, gamepad, wheel, touchpad, touch panel, pointing device, microphone, speaker, video camera, camera, scanner, printer, haptic device, vibrator, tactile simulator, and/or tactile pad, potentially including a port to which an I/O device can be attached or connected.
[83] liquid - a body of matter that exhibits a characteristic readiness to flow, little or no tendency to disperse, and relatively high incompressibility.
[84] longitudinal - of or relating to longitude or length.
[85] machine instructions - directions adapted to cause a machine, such as an information device, to perform a particular operation or function.
[86] machine readable medium - a physical structure from which a machine can obtain data and/or information. Examples include a memory, punch cards, etc.
[87] may - is allowed to, in at least some embodiments.
[88] memory device - an apparatus capable of storing analog or digital information, such as instructions and/or data. Examples include a non-volatile memory, volatile memory, Random Access Memory, RAM, Read Only Memory, ROM, flash memory, magnetic media, a hard disk, a floppy disk, a magnetic tape, an optical media, an optical disk, a compact disk, a CD, a digital versatile disk, a DVD, and/or a raid array, etc. The memory device can be coupled to a processor and/or can store instructions adapted to be executed by processor, such as according to an embodiment disclosed herein.
[89] method - a process, procedure, and/or collection of related activities for accomplishing something.
[90] microprocessor - an integrated circuit comprising a central processing unit.
[91] mixable - dissolvable, dispersible, and/or capable of being put into so that the dry substance is diffused and/or commingled in the liquid.
[92] needle - a hollow, slender, sharp-pointed instrument used for injection. Includes cannulas.
[93] network - a communicatively coupled plurality of nodes.
[94] network interface - any device, system, or subsystem capable of coupling an information device to a network. For example, a network interface can be a telephone, cellular phone, cellular modem, telephone data modem, fax modem, wireless transceiver, ethernet card, cable modem, digital subscriber line interface, bridge, hub, router, or other similar device.
[95] non-co-axial - not having co-linear axes.
[96] output device - an apparatus configured to visually, audibly, and/or haptically render information to a human. Examples include an audible output sub-system (e.g., speaker, horn, buzzer, and/or piezoelectric transducer, etc.), a visual output sub-system (e.g., flag, marker, light, liquid crystal display (LCD), light emitting diode (LED), optical fiber, organic polymer display, electric paper, screen, display, monitor, and/or tube, etc.), and a haptic output sub-system (e.g., buzzer, vibrator, bulging portion, tactile stimulator, cooler, and/or heater, etc.), etc.
[97] patient - a receiver of an injectable medicament, such as a human, mammal, animal, etc.
[98] piston - a sliding piece which either is moved by, or moves against, fluid pressure.
[99] pivotable - capable of pivoting.
[100] plurality - the state of being plural and/or more than one.
[101] predetermined - established in advance.
[102] processor - a device and/or set of machine-readable instructions for performing one or more predetermined tasks. A processor can comprise any one or a combination of hardware, firmware, and/or software. A processor can utilize mechanical, pneumatic, hydraulic, electrical, magnetic, optical, informational, chemical, and/or biological principles, signals, and/or inputs to perform the task(s). In certain embodiments, a processor can act upon information by manipulating, analyzing, modifying, converting, transmitting the information for use by an executable procedure and/or an information device, and/or routing the information to an output device. A processor can function as a central processing unit, local controller, remote controller, parallel controller, and/or distributed controller, etc. Unless stated otherwise, the processor can be a general-purpose device, such as a microcontroller and/or a microprocessor, such the Pentium IV series of microprocessor manufactured by the Intel Corporation of Santa Clara, California. In certain embodiments, the processor can be dedicated purpose device, such as an Application Specific Integrated Circuit (ASIC) or a Field Programmable Gate Array (FPGA) that has been designed to implement in its hardware and/or firmware at least a part of an embodiment disclosed herein.
[103] programmable logic controller (PLC) - a solid-state, microprocessor-based, hard real-time computing system that is used, via a network, to automatically monitor the status of field-connected sensor inputs, and automatically control communicatively-coupled devices of a controlled system (e.g., actuators, solenoids, relays, switches, motor starters, speed drives (e.g., variable frequency drives, silicon-controlled rectifiers, etc.), pilot lights, ignitors, speakers, tape drives, printers, monitors, displays, etc.) according to a user-created set of values and user-created logic and/or instructions stored in memory.
The sensor inputs reflect measurements and/or status information related to the controlled system. A PLC provides any of. automated input/output control; switching; counting; arithmetic operations;
complex data manipulation; logic; timing; sequencing;
communication; data file manipulation; report generation; control;
relay control; motion control; process control; distributed control;
and/or monitoring of processes, equipment, and/or other automation of the controlled system. Because of its precise and hard real-time timing and sequencing capabilities, a PLC is programmed using ladder logic or some form of structured programming language specified in IEC
61131-3, namely, FBD (Function Block Diagram), LD (Ladder Diagram), ST (Structured Text, Pascal type language), IL (Instruction List) and/or SFC (Sequential Function Chart). Because of its precise and real-time timing and sequencing capabilities, a PLC can replace up to thousands of relays and cam timers. PLC hardware often has good redundancy and fail-over capabilities. A PLC can use a Human-Machine Interface (HMI) for interacting with users for configuration, alarm reporting, and/or control.
[104] puncturer - a device adapted to penetrate using a substantially sharp and/or tapered point, tip, edge, or the like.
[105] pusher - a device adapted to convert-fluid pressure to mechanical movement.
[106] render - make perceptible to a human, for example as data, commands, text, graphics, audio, video, animation, and/or hyperlinks, etc., such as via any visual, audio, and/or haptic means, such as via a display, monitor, electric paper, ocular implant, cochlear implant, speaker, etc.
[107] repeatedly - again and again; repetitively.
[108] reservoir - a receptacle or chamber for storing and/or directing movement of a fluid.
[109] resist - to avoid and/or remain firm against the actions, effects, and/or force of.
[110] retract - to pull inward.
[111] safety tab - a removable device configured to prevent actuation of an auto-injector when the safety tab is in one orientation, and allow actuation when in another orientation.
[112] sensed variable - a measured parameter.
[113] set - a related plurality.
[114] sheath - a protective cover.
[115] shield - a protective device or structure.
[116] soft real-time - relating to computer systems that take a best efforts approach and minimize latency from event to response as much as possible while keeping throughput up with external events overall.
Such systems will not suffer a critical failure if time constraints are violated. For example, live audio-video systems are usually soft real-time; violation of time constraints can result in degraded quality, but the system can continue to operate. Another example is a network server, which is a system for which fast response is desired but for which there is no deadline. If the network server is highly loaded, its response time may slow with no failure in service. This is contrasted with the anti-lock braking system where a slow down in response would likely cause system failure, possibly even catastrophic failure.
[117] spring - an elastic device, such as a coil of wire, that regains its original shape after being compressed or extended.
[118] status - a state or condition.
[119] store - to place, hold, and/or retain data, typically in a memory.
[120] substantially - to a great extent or degree.
[121] system - a collection of mechanisms, devices, data, and/or instructions, the collection designed to perform one or more specific functions.
[122] tip - a terminal end.
[123] transfer - to convey from one place to another.
[124] translatable - capable of being transferred from one place to another and/or of being moved with respect to something else.
[125] triggerable - capable of being actuated.
[126] use indication - information regarding a use of an auto-injector, such as information regarding any of auto-injector selection; auto-injector maintenance; auto-injector expiration; auto-injector replacement;
medicament expiration; medicament selection; medicament mixing;
injection delay; safety guard removal; auto-injector positioning; auto-injector orientation; actuator location; injection hazard avoidance;
auto-injector actuation; injection duration; injection status; injection error; auto-injector removal; auto-injector reuse; auto-injector recycling; and auto-injector disposal, etc.
[127] user input - human-provided information.
[128] user interface - any device for rendering information to a user and/or requesting information from the user. A user interface includes at least one of textual, graphical, audio, video, animation, and/or haptic elements. A textual element can be provided, for example, by a printer, monitor, display, projector, etc. A graphical element can be provided, for example, via a monitor, display, projector, and/or visual indication device, such as a light, flag, beacon, etc. An audio element can be provided, for example, via a speaker, microphone, and/or other sound generating and/or receiving device. A video element or animation element can be provided, for example, via a monitor, display, projector, and/or other visual device. A haptic element can be provided, for example, via a very low frequency speaker, vibrator, tactile stimulator, tactile pad, simulator, keyboard, keypad, mouse, trackball, joystick, gamepad, wheel, touchpad, touch panel, pointing device, and/or other haptic device, etc. A user interface can include one or more textual elements such as, for example, one or more letters, number, symbols, etc. A user interface can include one or more graphical elements such as, for example, an image, photograph, drawing, icon, window, title bar, panel, sheet, tab, drawer, matrix, table, form, calendar, outline view, frame, dialog box, static text, text box, list, pick list, pop-up list, pull-down list, menu, tool bar, dock, check box, radio button, hyperlink, browser, button, control, palette, preview panel, color wheel, dial, slider, scroll bar, cursor, status bar, stepper, and/or progress indicator, etc. A textual and/or graphical element can be used for selecting, programming, adjusting, changing, specifying, etc. an appearance, background color, background style, border style, border thickness, foreground color, font, font style, font size, alignment, line spacing, indent, maximum data length, validation, query, cursor type, pointer type, autosizing, position, and/or dimension, etc. A user interface can include one or more audio elements such as, for example, a volume control, pitch control, speed control, voice selector, and/or one or more elements for controlling audio play, speed, pause, fast forward, reverse, etc. A user interface can include one or more video elements such as, for example, elements controlling video play, speed, pause, fast forward, reverse, zoom-in, zoom-out, rotate, and/or tilt, etc. A user interface can include one or more animation elements such as, for example, elements controlling animation play, pause, fast forward, reverse, zoom-in, zoom-out, rotate, tilt, color, intensity, speed, frequency, appearance, etc. A user interface can include one or more haptic elements such as, for example, elements utilizing tactile stimulus, force, pressure, vibration, motion, displacement, temperature, etc.
[129] valve - a device that regulates flow through a pipe and/or through an aperture by opening, closing, and/or obstructing a port and/or passageway.
[130] vent - to release from confinement.
[131] via - by way of and/or utilizing.
[132] vial - a closable vessel.
Detailed Description [133] Exposure, such as via ingestion, inhalation, and/or injection, to certain allergens, toxins, and/or other substances can cause profound reactions for some and/or all people and/or animals. For example, certain people are highly allergic to certain substances, such as peanuts, shellfish, particular drugs, certain proteins, bee venom, insect bites, etc. The allergic response to the exposure can lead to anaphylactic shock, which can cause a sharp drop in blood pressure, hives, and/or substantial breathing difficulties caused by severe airway constriction. As another example, inhalation of certain nerve agents can cause severe physiological trauma.Responding rapidly to such exposures can prevent injury and/or death. For example, in response to an exposure leading to anaphylactic shock, an injection of epinephrine (i.e., adrenaline) can provide substantial and/or complete relief from the reaction.
As another example, injection of an antidote to a nerve agent can greatly reduce and/or eliminate the potential harm of the exposure. As yet another example, rapid injection of certain drugs, such as a beta blocker, blood thinner, nitroglycerine, antihistamines, insulin, and opioids, etc., can provide substantial relief from various dangerous medical conditions.
[135] Thus, certain exemplary embodiments provide systems, devices, and/or methods for rapidly injecting a medicament.
[136) Certain exemplary embodiments comprise an apparatus, comprising: a compressed gas container; a plurality of vials adapted to store a liquid medicament, each vial defining a longitudinal axis, the longitudinal axes of the plurality of vials parallel and non-co-axial, the plurality of vials fluidly coupleable to an actuating portion of a contents of the gas container; and a plurality of pistons, each piston adapted to move within a corresponding vial from the plurality of vials, the plurality of pistons adapted to, in response to discharge of the actuating portion of the contents of the compressed gas container, transfer at least a portion of the liquid medicament from the plurality of vials and through a needle that is extendable into a patient.
Certain exemplary embodiments comprise a method comprising a plurality of activities, comprising: discharging an actuating portion of a contents of a compressed gas container, the compressed gas container contained within an apparatus; in reaction to said discharging activity, moving a piston within a vial, the vial one of a plurality of vials contained within the apparatus, each vial adapted to store a liquid medicament, each vial defining a longitudinal axis, the longitudinal axes of the plurality of vials parallel and non-co-axial, the plurality of vials fluidly coupleable to a contents of the gas container;
and transferring a liquid medicament from the vial and through a needle that is extendable into a patient.
[138] FIG. 1 is a perspective view, FIG. 2 is a front view, and FIG. 3 is a side view, of an exemplary embodiment of a system 1000, which can comprise a housing 1100, which, in certain operative embodiments, can comprise a handheld portion 1800 separated via an actuation guard 1200 from an actuation bar 1300. Actuation guard 1200 can prevent accident activation of system 1000.
Housing 1100 can be constructed of a durable material, such as stainless steel, aluminum, polycarbonate, etc., to protect a compressed gas container, medicament, injection apparatus and/or user of system 1000. The injection apparatus can be actuated by a fluid pressure, such as pressure provided by the compressed gas, which upon completion of its actuation duties can escape housing 1100 via gas escape opening, such as via status indicator 1400.
[139] A status of a system 1000 can be determined via status indicator 1400, which can provide a view, such as via a UV blocking, photo-sensitive, and/or translucent window, into an interior of housing 1100. Viewable through the window can be a status of medicament carried by housing 1100, a location of a needle and/or injection apparatus for the medicament, and/or an activation status of system 1000. For example, if the medicament has aged to the point of discoloration, which aging might or might not render the medication useless, harmful, etc., status indicator 1400 can allow that situation to be determined. In certain exemplary embodiments, gas can escape housing 1100 via status indicator 1400 and/or another opening in housing 1100.
[140] Certain exemplary embodiments of system 1000 can provide a compact medicament delivery mechanism that can efficiently and/or rapidly deliver a prescribed dose. The length (L) and width (W) of system 1000 can be similar to that of a credit card, and the thickness (T) can be less than one inch.
Thus, certain exemplary embodiments of system 1000 can provide a conveniently carried, easy-to-use, easy to activate drug delivery apparatus that can require little to no training to safely carry, use, and/or dispose of.
[141] To assist a user in positioning system 1000 in a correct orientation for injection, system 1000 and/or housing 1100 can provide various tactile clues.
For example, a top 1110 of housing 1100 can be rounded, and a bottom 1120 of actuation bar 1300 of housing 1100 can be flat. Other tactile clues are also possible, such as bulges, ribs, grooves, gaps, roughened surfaces, indentations, etc.
[142] FIG. 4 is a cross-sectional view taken along lines A-A of FIG. 3 of an exemplary embodiment of a system 1000 in a first operative position. FIGs.
5, 6, 7, 8, and 9 show system 1000 of FIG. 4 in second, third, fourth, fifth, and sixth operative positions, respectively.
[143] System 1000 can comprise a housing 1100, handheld portion 1800, actuation guard 1200, and/or actuation bar 1300. System 1000 can comprise system actuator 2000, gas reservoirs 3000, medicament actuator 4000, medicament storage assembly 5000, medicament carrier 9000, needle assembly 6000, use indicator 7000, and/or gas vent mechanism 8000, etc.
[144] Upon removal, release, rotation, and/or relocation of actuation guard 1200, system actuator 2000 can be adapted to rapidly discharge an actuating portion of a contents of a compress gas container. For example, system actuator 2000 can comprise a compressed gas container 2400, which initially can contain a compressed gas 2500, an actuating portion of which can be released from container 2400 by penetration of a gas port 2600 via a point of a punctures 2700. Upon removal and/or relocation of actuation guard 1200, actuation bar 1300 can be moved closer to and/or in contact with handheld portion 1800.
Upon removal and/or relocation of actuation guard 1200, gas container 2400 can be brought into contact with puncturer 2700 via extension of a pre-compressed spring 2300 and/or movement of a actuation stick 2200. Thus, actuation guard 1200 can prevent accident activation of system 1000 and/or unintended discharge of an actuating portion of the contents 2500 of gas container 2400.
[145] Once gas port 2600 has been punctured, an actuating portion of compressed gas 2500 can escape from container 2400 and flow via gas reservoirs 3000, such as gas channel 3100. The flowing gas can meet and/or apply gas pressure to medicament actuator 4000, which can comprise a pusher 4100, which can travel within a sleeve 1500 defined by walls 1520. Sleeve 1500 can be constructed of metal, stainless steel, aluminum, plastic, polycarbonate, etc.
Seals 4200, such as o-rings, can resist gas leakage, such as past pusher 4100 and/or out of housing 1100. Thus, pusher 4100 can function as a piston traveling within a cylinder, although it is not necessarily required that the cross-sectional shape of sleeve 1500 be round.
[146] Medicament actuator 4000 can interface with medicament storage assembly 5000. For example, medicament actuator 4000 can comprise a plurality of plungers 4300, each of which can be capped with a piston 4400 which can sealingly slide and/or move within a corresponding vial 5100 containing a liquid medicament 5200. For example, in response to pressure applied by an actuating portion of the contents 2500 of compressed gas container 2400, pusher 4100 can cause plungers 4300 and/or pistons 4400 to simultaneously move. The number of corresponding sets of plungers 4300, pistons 4400, and/or vials 5100 can be 2, 3, 4, 5, 6, or more. Pistons 4400 can be constructed of a resilient, durable, and/or sealing material, such as a rubber.
Each plunger 4300 from the plurality of plungers can define a longitudinal axis, the longitudinal axes (e.g., axes 4310, 4320, 4330, 4340) of the plurality of plungers parallel, non-coaxial, and/or co-planar.
[147] Each vial 5100 from the plurality of vials can be substantially cylindrical with a substantially round and/or substantially elliptical cross-sectional shape.
Thus, each vial 5100 can define a longitudinal axis, the longitudinal axes of the plurality of vials parallel, non-coaxial, and/or co-planar. The longitudinal axis of each vial can be co-axial with the longitudinal axis of its corresponding plunger.
[148] Each vial can be capped at one end with a frangible 5300, which can be burst when piston 4400 generates sufficient pressure upon medicament 5200, thereby allowing at least a portion of medicament 5200 to flow out of vial 5100 and into medicament carrier 9000. Thus, the plurality of vials can be fluidly coupleable to the actuating portion of the contents 2500 of gas container 2400.
[149] Medicament carrier 9000 can hold each of vials 5100 and can travel within sleeve 1500. Medicament carrier 9000 can comprise a plurality of channels 9200 adapted to receive medicament 5200 as it exits its respective vial 5100, and direct medicament 5200 to a common conduit 9300. Medicament carrier 9000 can interface with needle assembly 6000 and/or use indicator 7000.
[150] From common conduit 9300, medicament 5200 can enter needle assembly 6000, such as into a single needle 6100 via which medicament can approach needle tip 6200. As medicament actuator 4000 and/or medicament carrier 9000 are driven toward actuator bar 1300, needle tip 6200 can penetrate an end 6400 of needle sheath 6300 and exit actuator bar 1300 at needle port 1340.
[151] Referring to FIG. 5, upon movement of actuation bar 1300 closer to handheld portion 1800, sheath seat 1330 can come in contact with sheath tip 6400, thereby causing sheath 6300 to buckle and/or crumble. As actuator bar 1300 comes in contact with handheld portion 1800, bar stop 1320 can approach medicament carrier stop 9400, while carrier spring 1600 is compressed.
[152] Referring to FIG. 6, as at least a portion of contents 2500 of gas container 2400 escapes, it can flow through channel 3100. The gas, which can still be relatively pressurized, can begin to accumulate behind pusher 4100 to form an expanding gas chamber 3200 and to cause medicament actuator 4000, medicament storage assembly 5000, and medicament carrier 9000 to slide together within sleeve 1500. As medicament actuator 4000, medicament storage assembly 5000, and medicament carrier 9000 slide closer to actuator bar 1300, spring 1600 becomes increasingly compressed between bar stop 1320 and medicament carrier stop 9400. As medicament actuator 4000, medicament storage assembly 5000, and medicament carrier 9000 slide closer to actuator bar 1300, needle tip 6200 can extend further from actuator bar 1300 and sheath 6300 can become further compressed and/or deformed. At its ultimate extension point, needle tip 6200 can extend from housing 1100 from approximately 0.25 millimeters to approximately 20 millimeters, including all values and subranges therebetween, such as up to approximately 2 millimeters, greater than approximately 5 millimeters, from approximately 5.13 millimeters to approximately 9.98 millimeters, etc.
[153] Referring to FIG. 7, as gas chamber 3200 continues to expand, medicament carrier 9000 can be driven until medicament carrier stop 9400 contacts actuator bar stop 1300 thereby resisting further travel of medicament carrier 9000. At that point, additional expansion of gas chamber 3200 can cause medicament actuator 4000, pusher bar 4100, plungers 4300, and/or pistons 4400 to initiate travel with respect to medicament storage assembly 5000, thereby generating an expulsion pressure in vials 5100, and/or thereby rupturing frangibles 5300 and allowing medicament 5200 to enter medicament carrier 9000, and begin flowing through medicament channels 9200, medicament conduit 9300, needle 6100, and/or out needle tip 6200 and into a patient. Alternatively, frangibles 5300 can be replaced and/or augmented by a frangible located at or near where medicament conduit 9300 couples to needle 6100. Frangibles 5300 can be constructed of a thin, taught, resilient, durable, and/or sealing material potentially having a predetermined yield strength, such as a rubber, such as chromo butyl rubber, and/or of a relatively brittle material potentially having a predetermined yield strength, such as ceramic, certain plastics, such as polystyrene, etc.
[154] As medicament carrier stop 9400 contacts actuator bar stop 1300, medicament carrier hooks 9600 can engage with engagement receivers 7100 in use indicator 7000.
[155] Referring to FIG. 8, as gas chamber 3200 continues to expand, medicament actuator 4000, pusher bar 4100, plungers 4300, and/or pistons 4400 can continue moving until they complete their travel within medicament storage assembly 5000, thereby expelling a predetermined dose of medicament 5200 from vials 5100, out of needle assembly 6000, external to housing 1100, and/or into the patient. As gas chamber 3200 reaches its maximum size, medicament actuator 4000, pusher bar 4100, plungers 4300, and/or pistons 4400 can continue moving until they complete their travel with respect to medicament carrier 9000, thereby causing gas release actuator 9700 to engage with gas release valve 8200. Engagement of gas release actuator 9700 with gas release valve 8200 can cause within gas chamber 3200 to exit gas chamber 3200, discharge away from pistons 4400, and/or exhaust from system 1000 and/or housing 1100, such as via status indicator 1400 and/or a gas escape port located on housing 1100).
[156] Referring to FIG. 8 and FIG. 9, as sufficient gas is vented from gas chamber 3200, the pressure applied by the gas in gas chamber 3200 can decrease until the force applied by the gas on medicament actuator 4000 is less than the force of compressed spring 1600. Thus, spring(s) 1600 can begin to expand, thereby moving medicament carrier 9000, vial assembly 5000, and medicament actuator 4000 away from actuator bar 1300 and helping to exhaust gas from gas chamber 3200. As medicament carrier 9000 moves, use indicator 7000 can travel with it, due to the engaged relationship of medicament carrier hooks 9600 and engagement receivers 7100 and/or engagement catches 7200 in use indicator 7000. As use indicator 7000 moves away from actuation bar 1300, sheath 6300 can travel with it, thereby creating a gap between sheath tip 6400 and needle port 1340, and thereby exposing a previously non-visible colored portion 1350 of actuation bar 1300 and/or providing an indication that system 1000 has been used (and likely substantially exhausted of its medicament), thereby discouraging any further attempts to use system 1000.
[157] As medicament carrier 9000 moves away from actuator bar 1300, needle can retract into sheath 6300 which un-buckles and/or un-deforms towards its original shape. Eventually, needle 6100 can retract completely within the boundaries of housing 1100, thereby tending to prevent accidental needle sticks after the initial injection and/or potentially reducing and/or eliminating a sharps hazard.
[158] In certain exemplary embodiments, system actuator 2000 can comprise a finger triggered, twistable, pivotable, and/or lever-operated mechanism. For example, system actuator 2000 can comprise a twistable handle that can screw into gas port 2600. In certain exemplary embodiments, system actuator 2000 can be a finger trigger located on a side of the housing.
[159] FIG. 10 is a flowchart of an exemplary embodiment of a method 10000 for operating a medicament delivery apparatus. At activity 10100, an actuation lock for the apparatus is released. At activity 10200, an actuating portion of the contents of a compressed gas container are released. At activity 10300, via pressure provided by the released gas, a needle is extended from the apparatus.
At activity 10400, via pressure provided by the released gas, a piston applies pressure to a medicament stored in one of a plurality of vials. At activity 10500, a frangible containing the medicament in the vial is burst. At activity 10600, the medicament flows from the vial, through the needle, and into a patient. At activity 10700, once a predetermined dose is expelled and/or injected, the needle is withdrawn from the patient and/or retracted into the pre-use bounds of the apparatus. At activity 10800, the apparatus is rendered unusable for additional injections and/or indicated as previously utilized.
[160] FIG. 11 is a perspective view of an exemplary embodiment of system 1000, showing actuation guard 1200 removed from housing 1100, so that actuation guard 1200 no longer separates actuator bar 1300 from handheld portion 1800.
Actuation guard 1200 can comprise a grippable portion 1220 that can be gripped by a user to pull actuation guard 1200 away from housing 1100, thereby allowing system 1000 to be activated, such as via slapping actuator bar 1300 against a thigh of the user. Actuation guard 1200 can comprise an actuation stick separator portion 1240, that can keep separate actuation stick prongs 2240 when actuation guard 1200 is installed on housing 1100.
Actuation guard 1200 can comprise a guard portion 1260 that can separate actuator bar 1300 from handheld portion 1800 when system 1000 is not in use and/or when system 1000 has not been used.
[161] FIG. 12 is a perspective cross-sectional view taken along lines B-B of FIG.
11, and FIG. 13 is a perspective view of an exemplary embodiment of actuation stick 2200. Referring to FIGs. 12 and 13, system 1000 can comprise housing 1100, actuation bar 1300, and system actuator 2000, which can comprise prong squeezer 1390, actuation stick 2200, prong retainer 2100, spring 2300, upper spring retainer 2260, gas container 2400, gas port 2600, and/or puncturer 2700. When actuation bar 1300 is pressed firmly against a user's body, such as via slapping housing actuation bar against the user's thigh, buttocks, and/or arm, prong squeezer 1390 can urge prong tips 2220 of prongs 2240 of actuation stick 2200 toward one another. Note that prong tips 2200 can have a triangular, wedge, angular, and/or frustro-conical shape. As prongs tips 2220 slide along the angled V-groove of prong squeezer 1390, prong catches 2230 can substantially loose contact with prong retainer 2100.
This can allow compressed spring 2300 to rapidly urge actuation stick 2200 and gas container 2400 toward puncturer 2700, which can penetrate gas port 2600, thereby allowing gas to escape from gas container 2400. Although any of many different types of gas containers can be utilized, an exemplary gas container can be obtained from Leland Limited, Inc. of South Plainfield, NJ.
[162] FIG. 14 is a cross-sectional view of an exemplary embodiment of gas venting mechanism 8000 of system 1000 taken along lines A-A of FIG. 3. System 1000 can comprise handheld portion 1800, actuator bar 1300, sleeve 1500. As pistons 4440 near the limit of their travels, medicament 5200 can be expelled along medicament path 5900, which can extend past frangible 5300, through medicament channels 9200, medicament conduit 9300, and needle 6100, and into the body of a user, such as subcutaneously, intramuscularly, and/or at a depth of from approximately 0.25 millimeters to approximately 20 millimeters, including all values and subranges therebetween, such as up to 2 millimeters, greater than 5 millimeters, etc.
[163] As pistons 4440 near the limit of their travels, engagement of gas release actuator 9700 with gas release valve 8200 can cause compressed spring 8300 to move valve arm such that o-ring 8400 is urged away from its seat 8500.
This movement can reveal a passage 8600, via which gas can exit gas chamber 3200 along gas exhaust path 8900, which can extend between sleeve inner walls 1520 and outer walls 9100 of medicament carrier 9000. Eventually, gas exhaust path 8900 can extend between handheld portion 1800 and actuator bar 1300. Likewise, an alternative embodiment of valve 8200, made of rubber or any other resilient material, can be placed across seat 8500 to provide a seal that, once gas release actuator 9700 interacts with valve 8200, allows valve 8200 to bend or flap upwards away from seat 8500, causing the gas to escape via passage 8600.
[164] The following paragraphs expands on the above and describe various exemplary embodiments relating to compact auto-injectors that can comprise and/or utilize a vial or a plurality of vials to store and/or contain an injectable medicament. These auto-injectors can have a compact form factor, such as approximately the size of a credit card. There are many methods of delivering such medicaments in such compact devices. The below descriptions cover multiple methods and/or mechanisms that can effectively administer a medicament using a compact auto-injector.
Exemplary Embodiment One: Methods of Utilizing an Auto-injector [165] This exemplary embodiment describes a method of implementing an auto-injector utilizing a spring and/or gas driven system to administer a medicament and/or comprises a needle protection system.
[166] An embodiment for delivering medicament from a chamber can comprise a vial or plurality of vials; said chamber in communication with a needle that can be concealed initially by some shield and/or sheath; extending said needle from the sheath at least lmm and/or inserting the needle past a needle insertion point to an injection site at a depth of at least 5mm; the application of a force that can originate from the contents of a gas cylinder and/or by means of a spring or multiple springs sufficient to eject medicament held within said chamber into the needle and/or through the needle insertion point to a depth of at least 5mm to deliver up to 5 ml of medicament into the injection site in less than 5 seconds; wherein the medicament can be injected and/or held through the use of a vial system that comprises a plunger, vial(s), reservoir, and/or needle that can be located within said chamber; wherein the force can be applied on the plunger at the proximal end allowing for the plunger, vial(s), reservoir, and/or needle to travel towards the distal end of the housing;
wherein the plunger can slideably travel through the vial towards the distal end to allow for the appropriate dose of medicament to be delivered; wherein the needle insertion point can be located more superficial than the injection site; wherein the needle can have a length of at least 6mm and/or the medicament can be ejected at a pressure of at least 25 p.s.i. at a rate of at least 0.20 ml/sec; and/or wherein the needle can retract into the shield and/or housing and/or a needle protection portion slides over the needle following delivery of the medicament.
[1] FIG. 15 shows an exemplary embodiment an auto-injector 15000. Though the figure shows the force mechanism used as being compressed gas, the force method can be created by a spring force (See description of FIG. 18 below).
The top of the housing can be laser-welded to ensure stability due to high pressure. Likewise, the entire housing may be made smaller by eliminating screws and/or pins holding the base and/or top to the housing. In FIG. 15, this can be completed by adding hooks to the base. The hooks can allow the base to slide into the housing, thus pushing the detents inward and allowing for the puncturing of the gas cylinder by the compressed spring. These hooks can also click into the housing, making the base unable to move post-injection; this eliminates re-use of the device and acts as an indicator to determine if the device has been used or if the device has not been activated. The gas release mechanism is also a novel addition to the device. A rubber flap and/or other resilient material can be located inside the plunger bar. A solid piece or member can stick up from the reservoir near the top of the vials. Once the plunger bar dispenses the medicament, this piece can push the rubber flap up, thereby releasing excess gas in the system. The puncturing device for the gas cylinder could be a roll-pin that is sliced at a 45 degree angle to ensure sharpness for puncturing.
[167] FIG. 16 shows the safety tab used to protect the user from accidental activation. FIG. 16 also shows an extended portion of the safety tab with grooves added to it. This can aid the user in removing the safety tab by creating a larger gripping surface and/or a more tactile feel to the tab.
Exemplary Embodiment Two: Chemical Reaction [168] This exemplary embodiment involves an auto-injection system that utilizes a chemical reaction as an activation mechanism to deliver the medicament into a patient. It also comprises a needle protection system.
[169] This exemplary embodiment comprises a delivery system that can encompass a housing, vial or plurality of vials, plunger for each vial, single needle or needle cannula, and medicament or medicaments within the vial or plurality of vials; the vial or plurality of vials in communication with the plunger(s) at proximal end and in communication with a reservoir that contains a single needle or needle cannula at the distal end; the needle can be protected by some sheath/ shield; a chemical reaction capable of occurring when one chemical is allowed to interact with another chemical and/or a substance that may create such a reaction through the use of some activation mechanism; and said chemical reaction that can generate a force that is strong enough to drive said plunger, vial, reservoir, and needle towards the distal end of the housing;
the needle exiting said sheath/shield and entering an injection site; the plunger(s) slideable in the vial(s) that contain the medicament; and said medicament exiting the vials into through the reservoir and needle cannula into the injection site; upon exit of the desired contents of the vial, the entire needle, reservoir, vial, and plunger assembly can retract towards the proximal end of housing by some means such as a wire, spring, o-ring, and/or rubber membrane and/or a needle protection portion slides over the needle following delivery of the medicament.
[170] FIG. 17 is a view of the compact injector with several modifications to allow for a chemical reaction to occur as the primary force method in order to deliver the 'medication. In the particular drawing, the puncturing pin can include a rough surface. Likewise, the container used in the device can have a similar rough material and/or surface and can contain mostly Sodium Azide (NaN3). Once the spring (attached to the container) is activated, the two rough surfaces can simultaneously come in contact with each other to create a spark and puncture the Azide container. This can create an immediate chemical reaction because of the spark. The reaction (2 NaN3 -> 2 Na + 3 N2) can form hot nitrogen gas and sodium in order to create enough force to inject the medication. A modification to this figure can be made to include another container at the top in place of the puncturing pin that can break open from the force of the spring and second container, thus mixing the two chemicalss and can cause a chemical reaction to occur in order to produce the force needed.
Exemplary Embodiment Three: The Spring Driven Injector [171] Certain exemplary embodiments of the auto-injector can use a spring or multiple springs to inject the medicament into a patient. The novelty of this system can lie in the orientation of the activation springs and the vial system (that comprises the plunger, vial(s), reservoir and the needle/cannula) system.
Because the activation springs can be located in parallel to the vial system, the device can be smaller than existing devices on the market (that are linear in nature), potentially having a form factor that is approximately the size of a credit card.
[172] Certain exemplary embodiments can comprise a delivery system that can encompass a housing, vial or plurality of vials, plunger for each vial, single needle or needle cannula, and medicament and/or medicaments within the vial or plurality of vials; the vial or plurality of vials in communication with the plunger(s) at proximal end and in communication with a reservoir that contains a single needle or needle cannula at the distal end; the needle protected by some sheath/ shield; the housing further comprising at least one spring (this can comprise a gas spring, coil spring, leaf spring, etc.) wherein the spring(s) is parallel to the plunger, vial(s), and reservoir system and is in communication with a solid member (that can be made of rubber, plastic, metal, and/or some other resilient material) that is also in communication with the proximal end of the plunger such that when the spring(s) is activated, a force is applied on the plunger at the proximal end allowing for the plunger(s), vial(s), reservoir, and needle to travel towards the distal end of the housing;
wherein the plunger can slideably travel through the vial towards the distal end to allow for the appropriate dose of medicament to be delivered; the solid member is displaced away from the plunger, which can allow for the retraction of the entire needle, reservoir, vial(s), and plunger assembly towards proximal end of housing by some means such as a wire, spring, o-ring, and/or rubber membrane and/or for a needle protection portion to slide over the needle following delivery of the medicament.
k [173] FIG. 18 shows several views of the spring driven injector. The primary force used to push down the pusher bar, vial system, reservoir, and needle can be provided by compressed springs. In the cross-section drawing, two springs can be located on the outside of the central chamber (containing the pusher bar, vials, reservoir, and needle). The springs can be held in place by a rod coupled with hooks. Each spring can have a rolling solid member attached to it that is also connected to a bar that is held into a notch/indentation in the reservoir near the bottom of the vials. Furthermore, a solid beam can wrap around the top of the pusher bar and can attach to the aforementioned bar. The bar can slide in and out of the reservoir and the solid beam, but only if the rolling solid member is rolled away from the reservoir and beam. The device can be activated by the user pulling out the safety mechanism and pushing downward on the outside sleeve. This can cause the hooks from the rods holding the springs in place to pinch inward, thereby releasing the springs forcefully downward. As the springs are driven downward, the rolling solid member and bar can roll down through the solid member passage. As the rolling solid member is moved, the solid beam wrapped around the pusher bar can come down as well, pushing the needle into the user. The medication can then be delivered into the user and/or patient once the rolling solid member goes down even further, which can be continually driven by the force of the springs. The solid member passage eventually can turn away from the vial system and reservoir (also shown in the side view drawing as a hidden line).
This can slide the bar out of the reservoir and out of the beam, allowing for the retracting springs to push the pusher bar, vials, reservoir, and needle back into the housing.
Exemplary Embodiment Four: Pulley System [174) This exemplary embodiment can utilize a pulley system as the activation mechanism for injecting medicament into the patient and that can also comprise a needle protection system.
[175] Certain exemplary embodiments can comprise a delivery system that can encompass a housing, vial or plurality of vials, plunger for each vial, single needle or needle cannula, and medicament or medicaments within the vial or plurality of vials; the vial or plurality of vials in communication with the plunger(s) at proximal end and in communication with a reservoir that can contain a single needle or needle cannula at the distal end; the needle that can be protected by some sheath/ shield; the housing further comprising one or more spring pulley system(s) that can constitute a spring connected to some slideable resilient.material such as a string, wire, wire coil, flat metallic band, etc. at the proximal end of the housing, and said material that can travel through a channel in the housing from the proximal end of the housing towards the distal end of the housing and then returning through a parallel channel towards the proximal end wherein this material is connected to a solid member (made of rubber, plastic, metal, and/or some other resilient material);
the solid member in communication with the proximal end of the plunger such that when the spring is activated the spring can produce enough force to allow the pulley system to operate by having the resilient material, such as a cord, which can forcefully travel towards the proximal end of the housing and can cause the cord to move the solid member in communication with the plunger, vial(s), reservoir, and/or needle towards the distal end; wherein the needle can exit said sheath/shield and can enter an injection site; the plunger(s) slideable in the vial(s) that can contain the medicament; and said medicament can exit the vials into through the reservoir and/or needle cannula into the injection site; upon exit of the desired contents of the vial, the solid member can be displaced away from the plunger allowing for the entire needle, reservoir, vial(s), and/or plunger assembly to retract towards the proximal end of housing by some means such as a wire, spring, o-ring, and/or rubber membrane and/or a needle protection portion to slide over the needle following delivery of the medicament.
[176] A pulley system is shown in FIG. 19 as the primary method for forcing the pusher bar, vials, reservoir, and needle down for medicament injection.
Similar to the above spring-driven injector, the activation springs can be located parallel to the vial system and the device can be activated by the user pushing down on the outside sleeve of the device. The use of a pulley system can create a mechanical advantage, producing the proper force needed to efficiently push down the vial system and deliver the proper dose of medication. FIG. 19 shows a bar that can be connected to the end of the rod/spring member. This bar can be connected to the pulley system (that can comprise some resilient and/or moveable material). The other end of the pulley system can be connected on top of the pusher bar to a beam that can be able to slide when moved to a certain position. As the springs are driven downward, the pulley system can pull the pusher bar, vials, reservoir, and needle down as well. Similar to the spring-driven injector, the solid beam member on top of the pusher bar can slide down the solid member passage and eventually dislodge from the pusher bar. Once this occurs, the entire system can retract back within the housing due to the force from the retracting springs.
Exemplary Embodiment Five: The Needleless Injector [177] This exemplary embodiment can comprise a Needleless Injector that can be gas and/or spring activated and that can allow for a user to inject a medicament into a patient without the use of a needle. The use of a plurality of vials can be considered the novel component and can allow the device to be compact in nature, such as having the approximate length and width similar to that of a credit card.
[178] Certain exemplary embodiments for delivering medicament from a chamber can comprise a plurality of vials; the said chamber in communication with a passage into a small injection opening; the application of a force that can originate from the contents of a gas cylinder and/or by means of at least one spring that can eject medicament held within said chamber into the passage to the small injection opening, which can be defined and/or created by the housing and/or a small sterile rod that can be a needle or cannula allowing for the slight puncturing of the injection site in order to allow the medicament to be delivered, and through the tip of this small injection opening to a depth of at least 1mm, that can deliver up to 5 ml of medicament into the injection site;
wherein the medicament can be injected and held through the use of a vial system that comprises a plunger, vial(s), and/or reservoir all located within said chamber; wherein the force can be applied on the plunger at the proximal end allowing for the plunger, vial(s), and/or reservoir to travel towards the distal end of the housing; wherein the plunger can slideably travel through the vial towards the distal end to allow for the appropriate dose of medicament to be delivered through the reservoir into the small injection opening; wherein the injection opening point can be located more superficial than the injection site; wherein the medicament can be ejected at a pressure of at least 25 p.s.i.
(For example, in such embodiments, the pressure to deliver a dose of 0.5cc's could be about 100 pounds of force).
[179] FIG. 20 depicts the components of the needleless injector. The injector can be activated by removing a safety tab and pushing down on the housing. The rod with hooks holding the spring in place can be initiated by the base moving upwards and pushing the hooks inward. The spring can drive the high pressure gas cylinder into a puncturing pin, releasing the gas cylinder contents.
The gas cylinder contents can push down the pusher bar, vials, and reservoir into the small opening at the base of the device near the injection site. A
tiny cannula and/or needle can be located at the bottom of the reservoir and/or can be used for slightly puncturing the injection site. This slight puncture can allow the medicament stored in the vial to flow through the reservoir and into the injection site. Once the pressure is released, the entire system (including the pusher bar, vials, and reservoir) can be pushed back up within the housing by the retracting springs.
Exemplary Embodiment Six: The Multi-Pharmaceutical Injector [180] This exemplary embodiment can comprise a compact auto-injector that can incorporate a plurality of vials, allowing for multiple medicaments to be injected at one time or at different times. The use of a plurality of vials can be considered the novel component and also can have the advantage of creating a device that is compact in nature, such as one having the length and width of a credit card. The device also can comprise a needle protection system.
[181] Certain exemplary embodiments for delivering medicament from a chamber can comprise a plurality of vials; the said chamber or chambers in communication with a needle or needles that can be concealed initially by shields and/or sheaths; that can extend said needle from the said sheath at least lmm and can insert the needle past a needle insertion point to an injection site at a depth of at least 5mm; the application of a force and/or forces that can originate from the contents of a gas cylinder and/or multiple gas cylinders, and/or by means of a spring and/or springs sufficient to eject medicament held within said chamber into the needle and through the needle insertion point;
wherein the medicament can be injected and held through the use of a vial system and/or vial systems that can comprise a plunger, vial, reservoir, and/or needle all located within said chamber(s); wherein the force can be applied on the plunger at the proximal end allowing for the plunger, vial, reservoir, and/or needle to travel towards the distal end of the housing; wherein the plunger can slideably travel through the vial towards the distal end to allow for the appropriate dose of medicament to be delivered; wherein the needle insertion point can be located more superficial than the injection site. The device potentially having a multitude of said components (including but not limited to vials, plungers, gas cylinders, springs, needles, reservoirs, sheaths, shields, chambers, and/or retracting springs) in order to administer multiple medicaments into a patient at one time and/or at different times, as one dose and/or in multiple doses, depending on when each individual system is activated. The device can have selectors and/or other mechanisms to allow the user to choose which medicament to administer. Each individual system can comprise an activation mechanism (such as a spring and/or gas cylinder), a chamber within said housing, and a plunger, vial, reservoir, needle, and/or retraction spring; wherein upon exit of the desired contents of the vial, the entire needle, reservoir, vial, and/or plunger assembly retracts towards the proximal end of housing by some means such as a wire, spring, o-ring, and/or rubber membrane and/or a needle protection portion slides over the needle following delivery of the medicament.
[182] A method for administering multiple pharmaceuticals is depicted in FIG.
21.
The injector can include medicament selectors in order to allow the user to select which medicament to inject. The user can select the medicaments by sliding one or more selectors upward into their final position. An audible click or some other indicator may occur to alert the user to this final position.
Moving the selector or multiple selectors upwards can allow a pin to snap into the plunger rod and/or into the pusher bar, which can create an entire portion that can push the vial system downwards and can inject the medication through the vial, the reservoir and/or needle. (This method can also be used with the Needleless injector method as described earlier in this document) Methods such as this embodiment could be extremely useful in applications for anti-nerve agents or pain therapies. The device can also include a resilient material, such as rubber, to seal the selector openings and that can also slide within the housing once the selector is pushed upward. Once the aforementioned pins are in place, the device can function and activate similarly to that described above. A safety mechanism can be modified to eliminate the sliding selectors from being prematurely pushed upwards.
Exemplary Embodiment Seven: The WetlDry Injector [183] This exemplary embodiment can comprise a compact auto-injector that can have the ability to mix two or more medicaments in either a liquid or powder form to create one injectable medicament. The novel component of this device can be considered to be the use of a plurality of vials to deliver the medicament. The device also can comprise a needle protection system.
[184] An exemplary delivery system can comprise a housing, plurality of vials, plunger for each vial, a mixing activation mechanism, an activation chamber or vial, single needle or needle cannula, and/or a medicament or medicaments stored within each vial. Pre-injection, two or more medicaments can be stored separately in a vial and/or storage compartment and can communicate with each other once the mixing activation mechanism is initialized. The mixing activation mechanism could comprise a button, trigger, threaded rod, and or some other member that removes a piece or portion and/or punctures a piece or portion that is preventing each medicament to communicate with each other. The mixing activation mechanism may comprise a membrane, piece, and/or portion that may be removed pre-injection by the user in order to allow the separate vials and/or storage containers to communicate with each other.
The mixing activation mechanism can be a piece that is manipulated in some way by the user in order to cause the contents of each compartment to mix with each other. This communication may occur by shaking the device and/or may occur automatically with the mixing activation mechanism. For instance, the mixing activation mechanism may cause each medicament to be released into an activation chamber, which may itself be a separate vial. This mixed medicament can be the medicament that will be injected into the patient. The delivery system further encompassing the mixed medicament vial or plurality of mixed medicament vials in communication with the plunger(s) at the proximal end of the housing and in communication with a reservoir that can contain a single needle or needle cannula at the distal end; the needle can be protected by some sheath/ shield; the housing can further comprise a passage that is also in communication with the proximal end of the plunger such that when the spring(s) is activated from the distal or proximal end, a force can be applied through the passage on the plunger at the proximal end allowing for the plunger(s), vial(s), reservoir, and/or needle to travel towards the distal end of the housing; wherein the force provided can be caused by a spring, bar, contents from a gas cylinder, and/or other force mechanism; wherein the plunger can slideably travel through the vial towards the distal end to allow for the appropriate dose of medicament to be delivered; upon exit of the desired contents of the vial, the entire needle, reservoir, vial, and/or plunger assembly can retract towards the proximal end of housing by some means such as a wire, spring, o-ring, and/or rubber membrane and/or a needle protection portion slides over the needle following delivery of the medicament.
[185] FIG. 22 depicts a novel method for injecting lyophilized medications, and/or powdered biologics that could need to be reconstituted pre-injection. FIG. 22 shows a mechanism to mix and/or create an injectable medicament from two or more separate aforementioned substances. The figure depicts multiple vials that could have two substances in each vial separated by a pierceable membrane and/or other frangible piece. The vials in this embodiment can have one wet substance (such as sterilized water) and one dry substance (such as glucagons powder). The user can take off the safety tab which can prevent the user from accidental injection and/or pre-mature activation of the device.
Once the safety device is removed, the user can twist and/or rotate the twisting portion at the top of the housing. By rotating this top portion, the rods attached to this portion (which can be threaded rods) can move downward. These rods can be located in the vials and/or through the pusher bar. The rods can have a sharp piercing portion on the distal end which can aid in puncturing the aforementioned pierceable membrane that can separate the substances in the vial. Once the piercing rod punctures the frangible and/or pierceable membrane, the substances can mix together to form one medicament. The user can also shake the entire housing in order to aid in this mixing process.
Exemplary Embodiment Eight: Needle End Safety System [186] Certain exemplary embodiments can comprise a safety system that can allow a user to remove some cap, bar, lock at the same end of an auto-injector housing where the needle is located. This can allow the device to be ready for activation while still protecting the needle at the same time. Many auto-injectors, such as most pen-like injectors, have the activation safety mechanism on the opposite end of where the needle is located. In an emergency situation, the user may mistake this safety cap as protecting the needle, when in fact this is not the case. There have been many documented cases of digital injection into a user's thumb or finger because of this reason.
Having the safety mechanism at the same end of the needle can eliminate this risk.
Exemplary Embodiment Nine: Auto-injector with Feedback [187] The use of auto-injectors and drug delivery systems is common in the medical industry. Auto-injectors can deliver a range of medicaments into a patient, ranging from chronic therapies to critical care injectables. As more therapies are developed, the need for a vehicle to deliver these therapies is ever-increasing. Certain auto-injectors currently on the market can lack attributes that can allow the user to understand the device's functionality and/or operation. Thus, there is perceived a need for an auto-injector that can provide audible, haptic, and/or visual feedback to the user in order to effectively train and/or guide the user on how to properly operate the auto-injector and/or to mitigate user-related hazards that could occur when the device is not used correctly.
[188] The incidence of use-related hazards associated with auto-injectors is increasing. Common problems associated with certain injectors on the market include poor design, sharps exposure, and poor instruction. Many auto-injectors on the market are in the form of an apparatus that resembles a pen or marker. The safety mechanism for most of these devices can cause patient confusion as it is often protecting the activation mechanism and not the location where the needle protrudes out of the device. There have been numerous cases of the user accidentally injecting the needle into their own thumb or finger because of this hazard. Examples of devices that incorporate this design can include certain pen-type auto-injectors for allergic emergencies, and/or certain anti-nerve agent auto-injectors currently supplied to both domestic and foreign militaries. These devices, and most auto-injectors on the market, also can allow the needle to remain protruding out after use, thereby potentially causing a post-injection sharps hazard.
Further, many of these injectors exhibit poor instruction and/or labeling. Due to the cylindrical design of certain auto-injectors, the surface area for labeling can be small, rounded, and therefore can prevent a user from easily reading important information regarding the use of the device. For many injectors that are used in emergency situations, it can be important that the user be able to use the device correctly and efficiently. The user might not take or have time to read the instructions on the device during such a critical scenario.
[189] For one or more of these reasons, an interactive auto-injector or medical device is described that can provide a user with visual, haptic, and/or audible feedback in order to mitigate the aforementioned risks and/or to allow for easy injection of medications.
[190] Certain exemplary embodiments can provide an interactive auto-injector and/or a method of providing audible, haptic, and/or visual feedback to a user when operating the auto-injector. An auto-injector can be defined as any device that allows a user to deliver a medicament without having to manually prepare the injection. This can include pen delivered injectors, syringes, needleless injectors, gas powered auto-injectors, and/or any other auto-injector and/or medical device used to inject a pharmaceutical into a user/patient, etc.
[191] Certain exemplary embodiments can provide an auto-injector that can comprise an information device and/or system comprising at least one sensor (e.g., a pressure sensor, proximity sensor, tactile sensor, and/or biometric input device, etc.), switch (e.g., gate switch, microswitch, and/or pushbutton, etc.), embedded system (e.g., microprocessor, memory, embedded operating system, system bus, input/output interface, and/or network interface, etc.), audible output sub-system (e.g., speaker, horn, buzzer, and/or piezoelectric transducer, etc.), visual output sub-system (e.g., flag, marker, light, liquid crystal display (LCD), light emitting diode (LED), optical fiber, organic polymer display, electric paper, screen, display, monitor, and/or tube, etc.), haptic output sub-system (e.g., buzzer, vibrator, bulging portion, tactile stimulator, cooler, and/or heater, etc.), and/or any other component and/or sub-system that would aid in providing audible, visual, and/or haptic feedback to a user of the auto-injector, along with appropriate circuitry, control system(s), housing(s), shielding, electrical conductors, and/or power source(s), etc.
[192] Certain embodiments of auto-injectors can comprise a housing, safety mechanism, activation mechanism (such as a spring means or compressed gas cylinder), a vial or container for storing the medicament, and a needle for delivering the medicament. Certain exemplary embodiments can provide one or more audible, visual, and/or haptic outputs to guide and/or instruct the user how to use the auto-injector properly. Sensors and/or switches can be placed on the safety tab, on the bottom of the device where the needle comes out, and/or where the inner sleeve slides up to activate the device. Visual outputs can be placed at each of the aforementioned locations as well and/or instead.
An audible output sub-system can be placed anywhere on the device for audible feedback. A haptic output sub-system can be placed anywhere on the device. These electronically-triggered and/or active components and/or sub-systems can be incorporated into the labeling of the device and/or as a separate component to provide this visual, haptic, and/or audible feedback.
[193] For example, the user can push a button or switch on the device to initiate the audible, haptic, and/or visual output sub-system. A pre-recorded audible voice can tell the user to pull up on the safety tab, while a visual and/or haptic output can be rendered on the safety tab to provide a visual and/or haptic clue to the user as to where the safety tab is located. Once the safety tab is pulled up correctly, a sensor or switch could trigger the next step for the voice to announce, for example, asking the user to place the base of the device on the outer portion of their thigh while also triggering a visual output to light the base of the device. By way of further example, the user can be provided a visual clue in which at least a portion of the base of the device is lighted and/or colored red, and/or the user can be provided a haptic clue in which the base on the device is moved and/or the base is heated sufficiently (such as to between approximately 105 degrees F and approximately 120 degrees F, including all values and sub-ranges therebetween) to substantially warm, yet not burn, the user's skin. The embedded operating system, which can run in hard real-time to avoid delays that might be significant and/or life-threatening, can also recognize a failure to complete a step in a certain specific timeframe and cause the step to be repeated if necessary and/or provide negative feedback if the user fails to perform a step properly (e.g., via input from a sensor or switch, the operating system can timely notice that the device is not placed on the skin of the thigh correctly and can cause the audible output sub-system to tell the user to repeat the placement step). Once the user places the device on the thigh properly, the sensor or switch could trigger the next audible, visual, and/or haptic clue and/or output, such as asking the user to push down on the outside sleeve of the device with force. By instructing the user step-by-step through each task, user error and/or risks of certain hazards can be reduced and/or eliminated.
[194] Certain exemplary embodiments can provide a compact, credit card-sized auto-injector used to deliver a variety of medicaments, such as pharmaceuticals and/or agents. Though this auto-injector can eliminate many problems associated with certain pen-style auto-injectors, such as the sharps hazard and/or the poor safety tab design, there can be a need for an interactive auto-injector in order to aid in user instruction of the device and/or to help ensure the device is used properly any and/or every time it is needed. The following, and the attached figures, further describes such an auto-injector.
[195] FIG. 23 portrays an auto-injector having a housing similar to the length and width of a credit card, an activation mechanism on one side and a vial system non-coaxial with the activation mechanism. The activation mechanism can comprise a compressed spring and compressed gas cylinder used as the force mechanism, and a puncturing mechanism to dispel the contents of the compressed gas cylinder. A vial system can be comprised of a pusher bar, plungers, vial(s)/medicament storage container(s), a reservoir, a needle, and a needle sheath. Retraction springs located at the base of the reservoir can push the needle back within the housing after injection. A slideable base can be used to activate the activation mechanism, which can be transparent to show the location of the aforementioned needle. A safety tab can be located between the base and the housing and/or can keep the activation mechanism from being activated while protecting the user from the needle. Sensors and/or switches, which can help trigger audible, haptic, and/or visual feedback, can be located on the base and/or on the safety tab. A button and/or switch, which can help trigger audible, haptic, and/or visual feedback sub-system(s), can be located on the housing. The feedback sub-system(s) can be activated based on inputs received and/or interpreted by the embedded operating system.
[196] For example, an audible output sub-system located in the housing can provide audible feedback to the user of the device. The audible output sub-system can be comprised of one or more piezoelectric transducers, small and/or large cones and/or speakers, sensors, capacitors, memories, power sources (e.g., battery, fuel cell, spring-actuated generator, etc.) housing, wires, and any other electronic components needed to provide recorded audible feedback to a user.
The audible output sub-system can be activated by the aforementioned button or switch on the housing. The speaker can provide instructions for how the device is used and/or certain medication requirements.
[197] As another example, visual outputs can be located throughout the device, and/or on the base, safety tab, labeling, and/or housing to provide visual clues to the user. These visual outputs can be activated by the operating system once a sensor or switch is triggered. An LCD, optical polymer, LED, electric paper, and/or other form of display, monitor, and/or screen and/or other visual output can provide data to the user such as dosage amount, expiration date, instructions, Federal Drug Administration (FDA) requirements, and/or other labeling requirements, etc.
[198] Referring to FIGS. 24 and 25, the user can push the button on the housing to, via the embedded processor, activate the audible, haptic, and/or visual feedback sub-system on the auto-injector. For example, a voice from the audible output sub-system (now activated) can provide an audible message to the user, such as "Please remove the safety tab." The safety tab can also light up from visual outputs located on the safety tab. Once the safety tab is removed, a sensor can be triggered that can also trigger the next audible task from the audible output sub-system. If the safety tab is not removed within a certain timeframe, the first voice response can be repeated. The button or switch can be pressed several times or held in order to stop the process (in case the injector does not need to be used or the button was pressed accidentally). After the safety tab is removed, the next audible clue can be annunciated, such as "Please place the base of the device on the outer portion of your thigh." The base can simultaneously light up during this audible clue, providing a visual clue that demonstrates where the base is located and/or what portion of the base should be placed on the thigh. A sensor or switch, located on the base, can be used to help determine if the auto-injector is placed correctly on the injection site. The same switch and/or sensor, and/or another switch and/or sensor located on the base can help trigger the next audible message, such as "Push down on the top of the device to activate the injector."
That switch and/or sensor can also trigger one or more visual outputs to light up the labeling and/or an arrow pointing down toward the injection site (as shown in FIG. 24).
[199] Certain exemplary embodiments can comprise a compact auto-injector that can have the ability to mix two or more medicaments, agents, solutes, solvents, etc., in either a liquid or powder form and/or create one injectable medicament. Certain exemplary embodiments can include an interactive system that can provide haptic, audible, and/or visual feedback to provide the user with instructions, hints, and/or clues in order to use the device properly.
The auto-injector also can comprise a needle protection system.
[200] An exemplary delivery system can comprise a housing, plurality of vials, plunger for each vial, a mixing activation mechanism, an activation chamber or vial, single needle or needle cannula, and/or a medicament or medicaments stored within each vial, etc. Prior to injection, two or more medicaments can be stored separately in a vial and/or storage compartment and can fluidically communicate with each other once the mixing activation mechanism is initialized. The mixing activation mechanism can comprise a button, trigger, threaded rod, and or some other member that removes a piece or portion and/or punctures a piece or portion that is preventing each medicament from communicating with each other. The mixing activation mechanism can comprise a membrane, piece, and/or portion that can be removed pre-injection by the user in order to allow the separate vials and/or storage containers to fluidically communicate with each other. The mixing activation mechanism can be a piece that is manipulated in some way by the user in order to cause the contents of each compartment to mix with each other. This communication can occur by shaking the device and/or can occur automatically with the mixing activation mechanism. For instance, the mixing activation mechanism can cause each medicament to be released into an activation chamber, which may itself can be a separate vial. This mixed medicament can be the medicament that will be injected into the patient.
[201] The delivery system can comprise the mixed medicament vial or plurality of mixed medicament vials in mechanical and/or fluid communication with the plunger(s) at the proximal end of the housing and in mechanical and/or fluid communication with a reservoir that can contain a single needle or needle cannula at the distal end. The needle can be protected by a sheath and/or shield. The housing can comprise a passage that is also in mechanical and/or fluid communication with the proximal end of the plunger such that when the spring(s) is activated from the distal or proximal end, a force can be applied through the passage on the plunger at the proximal end allowing for the plunger(s), vial(s), reservoir, and/or needle to travel towards the distal end of the housing. The applied force can be caused by a spring, bar, contents from a gas cylinder, and/or other force mechanism. The plunger can slideably travel through the vial towards the distal end to allow for the appropriate dose of medicament to be delivered. Upon exit of the desired contents of the vial, the entire needle, reservoir, vial, and/or plunger assembly can retract towards the proximal end of housing by some means such as a wire, spring, o-ring, and/or rubber membrane and/or a needle protection portion slides over the needle following delivery of the medicament.
[202] The interactive system can comprise a speaker sub-system that can comprise piezos and/or other components to produce audible sounds and/or human voice; a haptic sub-system that can provide haptic feedback to the user; a visual sub-system that can comprise light emitting diodes, LCD's, optical fibers, and/or other components that can produce visual outputs such as light and/or color; a processor that can be used to control the activation of such components; a power source such as a battery that can power the aforementioned interactive system; and/or switches, buttons, and/or sensors that can activate certain visual, haptic, and/or audible clues at a particular moment.
[203] FIG. 25 depicts a novel method for injecting lyophilized medications, and/or powdered biologics that might need to be reconstituted pre-injection. FIG. 25 shows a mechanism to mix and/or create an injectable medicament from two or more separate aforementioned substances. FIG. 25 depicts multiple vials that can have, for example, at least two substances in each vial separated by one or more pierceable membranes and/or other frangible pieces. The vials can have at least one wet substance (such as sterilized water) and at least one dry substance (such as glucagon powder). The user can take off the safety tab, which can prevent the user from accidental injection and/or pre-mature activation of the device. Once the safety tab and/or device is removed, the user can twist and/or rotate the twisting portion at the top of the housing.
By rotating this top portion, the rods attached to this portion (which can be threaded rods) can move downward. These rods can be located in the vials and/or through the pusher bar. The rods can have a sharp piercing portion on the distal end which can aid in puncturing the aforementioned pierceable membrane(s) that can separate the substances in the vial. Once the piercing rod punctures the frangible and/or pierceable membrane(s), the substances previously separated thereby can mix together to form one medicament. The user can also shake the entire housing in order to aid in this mixing process.
[204] The device can include an electronic/interactive system to provide visual, haptic, and/or audible feedback to the user. This interactive system can include a microprocessor to control the specific feedback components, a speaker sub-system, a haptic sub-system, a sub-system of switches and/or sensors, a sub-system of LEDs or optics, a battery power source, and any other component needed to produce audible or visual outputs. Figure 4 portrays these components located throughout the device; however, the actual placement of these components is flexible. The user can activate the interactive system by pushing a button or switch located on the housing of the device. This button or switch can activate the processor which can then send signals to the audible output sub-system, haptic output sub-system, and/or visual output sub-system.
The audible output sub-system can provide an audible clue for the initial task, which can be in the form of a human, humanesque, and/or understandable voice stating, "Please remove the safety tab." A signal can also be sent simultaneously to the safety tab visual output (potentially one or more LEDs) to provide a visual light and/or color clue to the user as to where the safety tab is located. Once the safety tab is removed, a switch or sensor can send a signal to the processor and activate the next audible, haptic, and/or visual clue.
This can be a human voice that states "Please twist the top portion of the injector to activate the mixing mechanism." As with the safety tab, an LED or some other visual clue then can be activated, lighting up the mixing activation mechanism, and/or a haptic clue can be activated, such as vibrating, warming, cooling, bulging, moving, changing a texture of, etc., the mixing activation mechanism. A switch or sensor located near or on the mixing activation mechanism can be used to ensure that the mixing was complete and to trigger the next audible and/or visual clue by the processor. A voice next can state, "Please shake gently to mix the solution." After a certain amount of time, the processor then can send a signal to the audible output sub-system for the next task. This can be a voice that says, "Please place the injector on the outer portion of your thigh." A visual indicator of where the base/injector should be placed also can be simultaneously activated. A switch, sensor, or button then can recognize the correct placement of the device and trigger the next audible and visual clue. This can be a voice stating, "Push down on the top of the injector to activate the injection." Likewise, an arrow or some other visual and/or haptic clue can light up and/or be rendered to show the motion of how the injector should be pushed. The last clue can be an audible clue that states, "Hold in place for several seconds, remove, and dispose of properly,"
indicating that the injection is complete. Additional audible, haptic, and/or visual feedback sub-systems can be used to provide the user with important information such as the expiration of the drug, improper use, and/or error.
For instance, the device's LEDs or optics can blink, a display can render a message, a vibrator can vibrate, and/or an audible beep and/or voice can be activated after a particular time stamp is reached that corresponds to the expiration of the drug and/or device. As another example, once an auto-injector has been used, a message can be displayed describing proper disposal and/or recycling techniques.
[205] FIG. 26 is a block diagram of an exemplary embodiment of an information system and/or device 26000, which in certain operative embodiments can comprise, for example, the interactive, integral, embedded, audible, haptic, and/or visual feedback system, such as described herein. Information system and/or device 26000 can comprise any of numerous components, such as for example, one or more network interfaces 26100, one or more processors 26200 running an embedded, real-time, hard real-time, and/or soft real-time operating system, one or more memories 26300 containing instructions 26400, one or more input/output (I/O) devices 26500, and/or one or more user interfaces 26600 coupled to I/O device 26500, etc.
[206] In certain exemplary embodiments, via one or more user interfaces 26600, such as a graphical user interface, a user can view a rendering of information related to selecting, purchasing, obtaining, operating, maintaining, re-using, and/or disposing of an auto-injector. In certain exemplary embodiments, instructions 26400 can be modified and/or updated via replacing a removable memory 26300 and/or via replacing instructions 26400 (such as, e.g., via flashing an EEPROM, etc.). In certain exemplary embodiments, instructions 26400 can be modified and/or updated via downloading replacement instructions via network interface 26100. System 26000 can comprise a programmable logic controller.
[207] Still other practical and useful embodiments will become readily apparent to those skilled in this art from reading the above-recited detailed description and drawings of certain exemplary embodiments. It should be understood that numerous variations, modifications, and additional embodiments are possible, and accordingly, all such variations, modifications, and embodiments are to be regarded as being within the spirit and scope of this application.
[208] Thus, regardless of the content of any portion (e.g., title, field, background, summary, abstract, drawing figure, etc.) of this application, unless clearly specified to the contrary, such as via an explicit definition, assertion, or argument, with respect to any claim, whether of this application and/or any claim of any application claiming priority hereto, and whether originally presented or otherwise:
[209] there is no requirement for the inclusion of any particular described or illustrated characteristic, function, activity, or element, any particular sequence of activities, or any particular interrelationship of elements;
[210] any elements can be integrated, segregated, and/or duplicated;
[211] any activity can be repeated, performed by multiple entities, and/or performed in multiple jurisdictions; and [212] any activity or element can be specifically excluded, the sequence of activities can vary, and/or the interrelationship of elements can vary.
[213] Accordingly, the descriptions and drawings are to be regarded as illustrative in nature, and not as restrictive. Moreover, when any number or range is described herein, unless clearly stated otherwise, that number or range is approximate.
When any range is described herein, unless clearly stated otherwise, that range includes all values therein and all subranges therein. Any information in any material (e.g., a United States patent, United States patent application, book, article, etc.) that has been incorporated by reference herein, is only incorporated by reference to the extent that no conflict exists between such information and the other statements and drawings set forth herein. In the event of such conflict, including a conflict that would render invalid any claim herein or seeking priority hereto, then any such conflicting information in such incorporated by reference material is specifically not incorporated by reference herein.
classic example of a hard real-time computing system is the anti-lock brakes on a car. The hard real-time constraint, or deadline, in this system is the time in which the brakes must be released to prevent the wheel from locking. Another example is a car engine control system, in which a delayed control signal might cause engine failure or damage. Other examples of hard real-time embedded systems include medical systems such as heart pacemakers and industrial process controllers.
[751 hazardous condition - a situation marked by risk, danger, and/or peril.
[76] housing - something that covers, encloses, protects, holds, and/or supports.
[77] in reaction to - responding indirectly and/or directly to.
[78] indicate - to show, mark, signify, denote, evidence, evince, manifest, declare, enunciate, specify, explain, exhibit, present, reveal, disclose, and/or display.
[79] indicator - a device and/or substance that indicates.
[80] information device - any device capable of processing information, such as any general purpose and/or special purpose computer, such as a personal computer, workstation, server, minicomputer, mainframe, supercomputer, computer terminal, laptop, wearable computer, and/or Personal Digital Assistant (PDA), mobile terminal, Bluetooth device, communicator, "smart" phone (such as a Treo-like device), messaging service (e.g., Blackberry) receiver, pager, facsimile, cellular telephone, a traditional telephone, telephonic device, a programmed microprocessor or microcontroller and/or peripheral integrated circuit elements, an ASIC or other integrated circuit, a hardware electronic logic circuit such as a discrete element circuit, and/or a programmable logic device such as a PLD, PLA, FPGA, or PAL, or the like, etc. In general any device on which resides a finite state machine capable of implementing at least a portion of a method, structure, and/or or graphical user interface described herein may be used as an information device. An information device can comprise components such as one or more network interfaces, one or more processors, one or more memories containing instructions, and/or one or more input/output (1/0) devices, one or more user interfaces coupled to an I/O device, etc.
[81) injectable medicament - a medicine, medication, drug, pharmaceutical, prescriptive, agent, antidote, anti-venom, hormone, stimulant, vasodilator, anesthetic, and/or nutritional supplement that is substantially ready for injection.
[82] input/output (I/O) device - any sensory-oriented input and/or output device, such as an audio, visual, haptic, olfactory, and/or taste-oriented device, including, for example, a monitor, display, projector, overhead display, keyboard, keypad, mouse, trackball, joystick, gamepad, wheel, touchpad, touch panel, pointing device, microphone, speaker, video camera, camera, scanner, printer, haptic device, vibrator, tactile simulator, and/or tactile pad, potentially including a port to which an I/O device can be attached or connected.
[83] liquid - a body of matter that exhibits a characteristic readiness to flow, little or no tendency to disperse, and relatively high incompressibility.
[84] longitudinal - of or relating to longitude or length.
[85] machine instructions - directions adapted to cause a machine, such as an information device, to perform a particular operation or function.
[86] machine readable medium - a physical structure from which a machine can obtain data and/or information. Examples include a memory, punch cards, etc.
[87] may - is allowed to, in at least some embodiments.
[88] memory device - an apparatus capable of storing analog or digital information, such as instructions and/or data. Examples include a non-volatile memory, volatile memory, Random Access Memory, RAM, Read Only Memory, ROM, flash memory, magnetic media, a hard disk, a floppy disk, a magnetic tape, an optical media, an optical disk, a compact disk, a CD, a digital versatile disk, a DVD, and/or a raid array, etc. The memory device can be coupled to a processor and/or can store instructions adapted to be executed by processor, such as according to an embodiment disclosed herein.
[89] method - a process, procedure, and/or collection of related activities for accomplishing something.
[90] microprocessor - an integrated circuit comprising a central processing unit.
[91] mixable - dissolvable, dispersible, and/or capable of being put into so that the dry substance is diffused and/or commingled in the liquid.
[92] needle - a hollow, slender, sharp-pointed instrument used for injection. Includes cannulas.
[93] network - a communicatively coupled plurality of nodes.
[94] network interface - any device, system, or subsystem capable of coupling an information device to a network. For example, a network interface can be a telephone, cellular phone, cellular modem, telephone data modem, fax modem, wireless transceiver, ethernet card, cable modem, digital subscriber line interface, bridge, hub, router, or other similar device.
[95] non-co-axial - not having co-linear axes.
[96] output device - an apparatus configured to visually, audibly, and/or haptically render information to a human. Examples include an audible output sub-system (e.g., speaker, horn, buzzer, and/or piezoelectric transducer, etc.), a visual output sub-system (e.g., flag, marker, light, liquid crystal display (LCD), light emitting diode (LED), optical fiber, organic polymer display, electric paper, screen, display, monitor, and/or tube, etc.), and a haptic output sub-system (e.g., buzzer, vibrator, bulging portion, tactile stimulator, cooler, and/or heater, etc.), etc.
[97] patient - a receiver of an injectable medicament, such as a human, mammal, animal, etc.
[98] piston - a sliding piece which either is moved by, or moves against, fluid pressure.
[99] pivotable - capable of pivoting.
[100] plurality - the state of being plural and/or more than one.
[101] predetermined - established in advance.
[102] processor - a device and/or set of machine-readable instructions for performing one or more predetermined tasks. A processor can comprise any one or a combination of hardware, firmware, and/or software. A processor can utilize mechanical, pneumatic, hydraulic, electrical, magnetic, optical, informational, chemical, and/or biological principles, signals, and/or inputs to perform the task(s). In certain embodiments, a processor can act upon information by manipulating, analyzing, modifying, converting, transmitting the information for use by an executable procedure and/or an information device, and/or routing the information to an output device. A processor can function as a central processing unit, local controller, remote controller, parallel controller, and/or distributed controller, etc. Unless stated otherwise, the processor can be a general-purpose device, such as a microcontroller and/or a microprocessor, such the Pentium IV series of microprocessor manufactured by the Intel Corporation of Santa Clara, California. In certain embodiments, the processor can be dedicated purpose device, such as an Application Specific Integrated Circuit (ASIC) or a Field Programmable Gate Array (FPGA) that has been designed to implement in its hardware and/or firmware at least a part of an embodiment disclosed herein.
[103] programmable logic controller (PLC) - a solid-state, microprocessor-based, hard real-time computing system that is used, via a network, to automatically monitor the status of field-connected sensor inputs, and automatically control communicatively-coupled devices of a controlled system (e.g., actuators, solenoids, relays, switches, motor starters, speed drives (e.g., variable frequency drives, silicon-controlled rectifiers, etc.), pilot lights, ignitors, speakers, tape drives, printers, monitors, displays, etc.) according to a user-created set of values and user-created logic and/or instructions stored in memory.
The sensor inputs reflect measurements and/or status information related to the controlled system. A PLC provides any of. automated input/output control; switching; counting; arithmetic operations;
complex data manipulation; logic; timing; sequencing;
communication; data file manipulation; report generation; control;
relay control; motion control; process control; distributed control;
and/or monitoring of processes, equipment, and/or other automation of the controlled system. Because of its precise and hard real-time timing and sequencing capabilities, a PLC is programmed using ladder logic or some form of structured programming language specified in IEC
61131-3, namely, FBD (Function Block Diagram), LD (Ladder Diagram), ST (Structured Text, Pascal type language), IL (Instruction List) and/or SFC (Sequential Function Chart). Because of its precise and real-time timing and sequencing capabilities, a PLC can replace up to thousands of relays and cam timers. PLC hardware often has good redundancy and fail-over capabilities. A PLC can use a Human-Machine Interface (HMI) for interacting with users for configuration, alarm reporting, and/or control.
[104] puncturer - a device adapted to penetrate using a substantially sharp and/or tapered point, tip, edge, or the like.
[105] pusher - a device adapted to convert-fluid pressure to mechanical movement.
[106] render - make perceptible to a human, for example as data, commands, text, graphics, audio, video, animation, and/or hyperlinks, etc., such as via any visual, audio, and/or haptic means, such as via a display, monitor, electric paper, ocular implant, cochlear implant, speaker, etc.
[107] repeatedly - again and again; repetitively.
[108] reservoir - a receptacle or chamber for storing and/or directing movement of a fluid.
[109] resist - to avoid and/or remain firm against the actions, effects, and/or force of.
[110] retract - to pull inward.
[111] safety tab - a removable device configured to prevent actuation of an auto-injector when the safety tab is in one orientation, and allow actuation when in another orientation.
[112] sensed variable - a measured parameter.
[113] set - a related plurality.
[114] sheath - a protective cover.
[115] shield - a protective device or structure.
[116] soft real-time - relating to computer systems that take a best efforts approach and minimize latency from event to response as much as possible while keeping throughput up with external events overall.
Such systems will not suffer a critical failure if time constraints are violated. For example, live audio-video systems are usually soft real-time; violation of time constraints can result in degraded quality, but the system can continue to operate. Another example is a network server, which is a system for which fast response is desired but for which there is no deadline. If the network server is highly loaded, its response time may slow with no failure in service. This is contrasted with the anti-lock braking system where a slow down in response would likely cause system failure, possibly even catastrophic failure.
[117] spring - an elastic device, such as a coil of wire, that regains its original shape after being compressed or extended.
[118] status - a state or condition.
[119] store - to place, hold, and/or retain data, typically in a memory.
[120] substantially - to a great extent or degree.
[121] system - a collection of mechanisms, devices, data, and/or instructions, the collection designed to perform one or more specific functions.
[122] tip - a terminal end.
[123] transfer - to convey from one place to another.
[124] translatable - capable of being transferred from one place to another and/or of being moved with respect to something else.
[125] triggerable - capable of being actuated.
[126] use indication - information regarding a use of an auto-injector, such as information regarding any of auto-injector selection; auto-injector maintenance; auto-injector expiration; auto-injector replacement;
medicament expiration; medicament selection; medicament mixing;
injection delay; safety guard removal; auto-injector positioning; auto-injector orientation; actuator location; injection hazard avoidance;
auto-injector actuation; injection duration; injection status; injection error; auto-injector removal; auto-injector reuse; auto-injector recycling; and auto-injector disposal, etc.
[127] user input - human-provided information.
[128] user interface - any device for rendering information to a user and/or requesting information from the user. A user interface includes at least one of textual, graphical, audio, video, animation, and/or haptic elements. A textual element can be provided, for example, by a printer, monitor, display, projector, etc. A graphical element can be provided, for example, via a monitor, display, projector, and/or visual indication device, such as a light, flag, beacon, etc. An audio element can be provided, for example, via a speaker, microphone, and/or other sound generating and/or receiving device. A video element or animation element can be provided, for example, via a monitor, display, projector, and/or other visual device. A haptic element can be provided, for example, via a very low frequency speaker, vibrator, tactile stimulator, tactile pad, simulator, keyboard, keypad, mouse, trackball, joystick, gamepad, wheel, touchpad, touch panel, pointing device, and/or other haptic device, etc. A user interface can include one or more textual elements such as, for example, one or more letters, number, symbols, etc. A user interface can include one or more graphical elements such as, for example, an image, photograph, drawing, icon, window, title bar, panel, sheet, tab, drawer, matrix, table, form, calendar, outline view, frame, dialog box, static text, text box, list, pick list, pop-up list, pull-down list, menu, tool bar, dock, check box, radio button, hyperlink, browser, button, control, palette, preview panel, color wheel, dial, slider, scroll bar, cursor, status bar, stepper, and/or progress indicator, etc. A textual and/or graphical element can be used for selecting, programming, adjusting, changing, specifying, etc. an appearance, background color, background style, border style, border thickness, foreground color, font, font style, font size, alignment, line spacing, indent, maximum data length, validation, query, cursor type, pointer type, autosizing, position, and/or dimension, etc. A user interface can include one or more audio elements such as, for example, a volume control, pitch control, speed control, voice selector, and/or one or more elements for controlling audio play, speed, pause, fast forward, reverse, etc. A user interface can include one or more video elements such as, for example, elements controlling video play, speed, pause, fast forward, reverse, zoom-in, zoom-out, rotate, and/or tilt, etc. A user interface can include one or more animation elements such as, for example, elements controlling animation play, pause, fast forward, reverse, zoom-in, zoom-out, rotate, tilt, color, intensity, speed, frequency, appearance, etc. A user interface can include one or more haptic elements such as, for example, elements utilizing tactile stimulus, force, pressure, vibration, motion, displacement, temperature, etc.
[129] valve - a device that regulates flow through a pipe and/or through an aperture by opening, closing, and/or obstructing a port and/or passageway.
[130] vent - to release from confinement.
[131] via - by way of and/or utilizing.
[132] vial - a closable vessel.
Detailed Description [133] Exposure, such as via ingestion, inhalation, and/or injection, to certain allergens, toxins, and/or other substances can cause profound reactions for some and/or all people and/or animals. For example, certain people are highly allergic to certain substances, such as peanuts, shellfish, particular drugs, certain proteins, bee venom, insect bites, etc. The allergic response to the exposure can lead to anaphylactic shock, which can cause a sharp drop in blood pressure, hives, and/or substantial breathing difficulties caused by severe airway constriction. As another example, inhalation of certain nerve agents can cause severe physiological trauma.Responding rapidly to such exposures can prevent injury and/or death. For example, in response to an exposure leading to anaphylactic shock, an injection of epinephrine (i.e., adrenaline) can provide substantial and/or complete relief from the reaction.
As another example, injection of an antidote to a nerve agent can greatly reduce and/or eliminate the potential harm of the exposure. As yet another example, rapid injection of certain drugs, such as a beta blocker, blood thinner, nitroglycerine, antihistamines, insulin, and opioids, etc., can provide substantial relief from various dangerous medical conditions.
[135] Thus, certain exemplary embodiments provide systems, devices, and/or methods for rapidly injecting a medicament.
[136) Certain exemplary embodiments comprise an apparatus, comprising: a compressed gas container; a plurality of vials adapted to store a liquid medicament, each vial defining a longitudinal axis, the longitudinal axes of the plurality of vials parallel and non-co-axial, the plurality of vials fluidly coupleable to an actuating portion of a contents of the gas container; and a plurality of pistons, each piston adapted to move within a corresponding vial from the plurality of vials, the plurality of pistons adapted to, in response to discharge of the actuating portion of the contents of the compressed gas container, transfer at least a portion of the liquid medicament from the plurality of vials and through a needle that is extendable into a patient.
Certain exemplary embodiments comprise a method comprising a plurality of activities, comprising: discharging an actuating portion of a contents of a compressed gas container, the compressed gas container contained within an apparatus; in reaction to said discharging activity, moving a piston within a vial, the vial one of a plurality of vials contained within the apparatus, each vial adapted to store a liquid medicament, each vial defining a longitudinal axis, the longitudinal axes of the plurality of vials parallel and non-co-axial, the plurality of vials fluidly coupleable to a contents of the gas container;
and transferring a liquid medicament from the vial and through a needle that is extendable into a patient.
[138] FIG. 1 is a perspective view, FIG. 2 is a front view, and FIG. 3 is a side view, of an exemplary embodiment of a system 1000, which can comprise a housing 1100, which, in certain operative embodiments, can comprise a handheld portion 1800 separated via an actuation guard 1200 from an actuation bar 1300. Actuation guard 1200 can prevent accident activation of system 1000.
Housing 1100 can be constructed of a durable material, such as stainless steel, aluminum, polycarbonate, etc., to protect a compressed gas container, medicament, injection apparatus and/or user of system 1000. The injection apparatus can be actuated by a fluid pressure, such as pressure provided by the compressed gas, which upon completion of its actuation duties can escape housing 1100 via gas escape opening, such as via status indicator 1400.
[139] A status of a system 1000 can be determined via status indicator 1400, which can provide a view, such as via a UV blocking, photo-sensitive, and/or translucent window, into an interior of housing 1100. Viewable through the window can be a status of medicament carried by housing 1100, a location of a needle and/or injection apparatus for the medicament, and/or an activation status of system 1000. For example, if the medicament has aged to the point of discoloration, which aging might or might not render the medication useless, harmful, etc., status indicator 1400 can allow that situation to be determined. In certain exemplary embodiments, gas can escape housing 1100 via status indicator 1400 and/or another opening in housing 1100.
[140] Certain exemplary embodiments of system 1000 can provide a compact medicament delivery mechanism that can efficiently and/or rapidly deliver a prescribed dose. The length (L) and width (W) of system 1000 can be similar to that of a credit card, and the thickness (T) can be less than one inch.
Thus, certain exemplary embodiments of system 1000 can provide a conveniently carried, easy-to-use, easy to activate drug delivery apparatus that can require little to no training to safely carry, use, and/or dispose of.
[141] To assist a user in positioning system 1000 in a correct orientation for injection, system 1000 and/or housing 1100 can provide various tactile clues.
For example, a top 1110 of housing 1100 can be rounded, and a bottom 1120 of actuation bar 1300 of housing 1100 can be flat. Other tactile clues are also possible, such as bulges, ribs, grooves, gaps, roughened surfaces, indentations, etc.
[142] FIG. 4 is a cross-sectional view taken along lines A-A of FIG. 3 of an exemplary embodiment of a system 1000 in a first operative position. FIGs.
5, 6, 7, 8, and 9 show system 1000 of FIG. 4 in second, third, fourth, fifth, and sixth operative positions, respectively.
[143] System 1000 can comprise a housing 1100, handheld portion 1800, actuation guard 1200, and/or actuation bar 1300. System 1000 can comprise system actuator 2000, gas reservoirs 3000, medicament actuator 4000, medicament storage assembly 5000, medicament carrier 9000, needle assembly 6000, use indicator 7000, and/or gas vent mechanism 8000, etc.
[144] Upon removal, release, rotation, and/or relocation of actuation guard 1200, system actuator 2000 can be adapted to rapidly discharge an actuating portion of a contents of a compress gas container. For example, system actuator 2000 can comprise a compressed gas container 2400, which initially can contain a compressed gas 2500, an actuating portion of which can be released from container 2400 by penetration of a gas port 2600 via a point of a punctures 2700. Upon removal and/or relocation of actuation guard 1200, actuation bar 1300 can be moved closer to and/or in contact with handheld portion 1800.
Upon removal and/or relocation of actuation guard 1200, gas container 2400 can be brought into contact with puncturer 2700 via extension of a pre-compressed spring 2300 and/or movement of a actuation stick 2200. Thus, actuation guard 1200 can prevent accident activation of system 1000 and/or unintended discharge of an actuating portion of the contents 2500 of gas container 2400.
[145] Once gas port 2600 has been punctured, an actuating portion of compressed gas 2500 can escape from container 2400 and flow via gas reservoirs 3000, such as gas channel 3100. The flowing gas can meet and/or apply gas pressure to medicament actuator 4000, which can comprise a pusher 4100, which can travel within a sleeve 1500 defined by walls 1520. Sleeve 1500 can be constructed of metal, stainless steel, aluminum, plastic, polycarbonate, etc.
Seals 4200, such as o-rings, can resist gas leakage, such as past pusher 4100 and/or out of housing 1100. Thus, pusher 4100 can function as a piston traveling within a cylinder, although it is not necessarily required that the cross-sectional shape of sleeve 1500 be round.
[146] Medicament actuator 4000 can interface with medicament storage assembly 5000. For example, medicament actuator 4000 can comprise a plurality of plungers 4300, each of which can be capped with a piston 4400 which can sealingly slide and/or move within a corresponding vial 5100 containing a liquid medicament 5200. For example, in response to pressure applied by an actuating portion of the contents 2500 of compressed gas container 2400, pusher 4100 can cause plungers 4300 and/or pistons 4400 to simultaneously move. The number of corresponding sets of plungers 4300, pistons 4400, and/or vials 5100 can be 2, 3, 4, 5, 6, or more. Pistons 4400 can be constructed of a resilient, durable, and/or sealing material, such as a rubber.
Each plunger 4300 from the plurality of plungers can define a longitudinal axis, the longitudinal axes (e.g., axes 4310, 4320, 4330, 4340) of the plurality of plungers parallel, non-coaxial, and/or co-planar.
[147] Each vial 5100 from the plurality of vials can be substantially cylindrical with a substantially round and/or substantially elliptical cross-sectional shape.
Thus, each vial 5100 can define a longitudinal axis, the longitudinal axes of the plurality of vials parallel, non-coaxial, and/or co-planar. The longitudinal axis of each vial can be co-axial with the longitudinal axis of its corresponding plunger.
[148] Each vial can be capped at one end with a frangible 5300, which can be burst when piston 4400 generates sufficient pressure upon medicament 5200, thereby allowing at least a portion of medicament 5200 to flow out of vial 5100 and into medicament carrier 9000. Thus, the plurality of vials can be fluidly coupleable to the actuating portion of the contents 2500 of gas container 2400.
[149] Medicament carrier 9000 can hold each of vials 5100 and can travel within sleeve 1500. Medicament carrier 9000 can comprise a plurality of channels 9200 adapted to receive medicament 5200 as it exits its respective vial 5100, and direct medicament 5200 to a common conduit 9300. Medicament carrier 9000 can interface with needle assembly 6000 and/or use indicator 7000.
[150] From common conduit 9300, medicament 5200 can enter needle assembly 6000, such as into a single needle 6100 via which medicament can approach needle tip 6200. As medicament actuator 4000 and/or medicament carrier 9000 are driven toward actuator bar 1300, needle tip 6200 can penetrate an end 6400 of needle sheath 6300 and exit actuator bar 1300 at needle port 1340.
[151] Referring to FIG. 5, upon movement of actuation bar 1300 closer to handheld portion 1800, sheath seat 1330 can come in contact with sheath tip 6400, thereby causing sheath 6300 to buckle and/or crumble. As actuator bar 1300 comes in contact with handheld portion 1800, bar stop 1320 can approach medicament carrier stop 9400, while carrier spring 1600 is compressed.
[152] Referring to FIG. 6, as at least a portion of contents 2500 of gas container 2400 escapes, it can flow through channel 3100. The gas, which can still be relatively pressurized, can begin to accumulate behind pusher 4100 to form an expanding gas chamber 3200 and to cause medicament actuator 4000, medicament storage assembly 5000, and medicament carrier 9000 to slide together within sleeve 1500. As medicament actuator 4000, medicament storage assembly 5000, and medicament carrier 9000 slide closer to actuator bar 1300, spring 1600 becomes increasingly compressed between bar stop 1320 and medicament carrier stop 9400. As medicament actuator 4000, medicament storage assembly 5000, and medicament carrier 9000 slide closer to actuator bar 1300, needle tip 6200 can extend further from actuator bar 1300 and sheath 6300 can become further compressed and/or deformed. At its ultimate extension point, needle tip 6200 can extend from housing 1100 from approximately 0.25 millimeters to approximately 20 millimeters, including all values and subranges therebetween, such as up to approximately 2 millimeters, greater than approximately 5 millimeters, from approximately 5.13 millimeters to approximately 9.98 millimeters, etc.
[153] Referring to FIG. 7, as gas chamber 3200 continues to expand, medicament carrier 9000 can be driven until medicament carrier stop 9400 contacts actuator bar stop 1300 thereby resisting further travel of medicament carrier 9000. At that point, additional expansion of gas chamber 3200 can cause medicament actuator 4000, pusher bar 4100, plungers 4300, and/or pistons 4400 to initiate travel with respect to medicament storage assembly 5000, thereby generating an expulsion pressure in vials 5100, and/or thereby rupturing frangibles 5300 and allowing medicament 5200 to enter medicament carrier 9000, and begin flowing through medicament channels 9200, medicament conduit 9300, needle 6100, and/or out needle tip 6200 and into a patient. Alternatively, frangibles 5300 can be replaced and/or augmented by a frangible located at or near where medicament conduit 9300 couples to needle 6100. Frangibles 5300 can be constructed of a thin, taught, resilient, durable, and/or sealing material potentially having a predetermined yield strength, such as a rubber, such as chromo butyl rubber, and/or of a relatively brittle material potentially having a predetermined yield strength, such as ceramic, certain plastics, such as polystyrene, etc.
[154] As medicament carrier stop 9400 contacts actuator bar stop 1300, medicament carrier hooks 9600 can engage with engagement receivers 7100 in use indicator 7000.
[155] Referring to FIG. 8, as gas chamber 3200 continues to expand, medicament actuator 4000, pusher bar 4100, plungers 4300, and/or pistons 4400 can continue moving until they complete their travel within medicament storage assembly 5000, thereby expelling a predetermined dose of medicament 5200 from vials 5100, out of needle assembly 6000, external to housing 1100, and/or into the patient. As gas chamber 3200 reaches its maximum size, medicament actuator 4000, pusher bar 4100, plungers 4300, and/or pistons 4400 can continue moving until they complete their travel with respect to medicament carrier 9000, thereby causing gas release actuator 9700 to engage with gas release valve 8200. Engagement of gas release actuator 9700 with gas release valve 8200 can cause within gas chamber 3200 to exit gas chamber 3200, discharge away from pistons 4400, and/or exhaust from system 1000 and/or housing 1100, such as via status indicator 1400 and/or a gas escape port located on housing 1100).
[156] Referring to FIG. 8 and FIG. 9, as sufficient gas is vented from gas chamber 3200, the pressure applied by the gas in gas chamber 3200 can decrease until the force applied by the gas on medicament actuator 4000 is less than the force of compressed spring 1600. Thus, spring(s) 1600 can begin to expand, thereby moving medicament carrier 9000, vial assembly 5000, and medicament actuator 4000 away from actuator bar 1300 and helping to exhaust gas from gas chamber 3200. As medicament carrier 9000 moves, use indicator 7000 can travel with it, due to the engaged relationship of medicament carrier hooks 9600 and engagement receivers 7100 and/or engagement catches 7200 in use indicator 7000. As use indicator 7000 moves away from actuation bar 1300, sheath 6300 can travel with it, thereby creating a gap between sheath tip 6400 and needle port 1340, and thereby exposing a previously non-visible colored portion 1350 of actuation bar 1300 and/or providing an indication that system 1000 has been used (and likely substantially exhausted of its medicament), thereby discouraging any further attempts to use system 1000.
[157] As medicament carrier 9000 moves away from actuator bar 1300, needle can retract into sheath 6300 which un-buckles and/or un-deforms towards its original shape. Eventually, needle 6100 can retract completely within the boundaries of housing 1100, thereby tending to prevent accidental needle sticks after the initial injection and/or potentially reducing and/or eliminating a sharps hazard.
[158] In certain exemplary embodiments, system actuator 2000 can comprise a finger triggered, twistable, pivotable, and/or lever-operated mechanism. For example, system actuator 2000 can comprise a twistable handle that can screw into gas port 2600. In certain exemplary embodiments, system actuator 2000 can be a finger trigger located on a side of the housing.
[159] FIG. 10 is a flowchart of an exemplary embodiment of a method 10000 for operating a medicament delivery apparatus. At activity 10100, an actuation lock for the apparatus is released. At activity 10200, an actuating portion of the contents of a compressed gas container are released. At activity 10300, via pressure provided by the released gas, a needle is extended from the apparatus.
At activity 10400, via pressure provided by the released gas, a piston applies pressure to a medicament stored in one of a plurality of vials. At activity 10500, a frangible containing the medicament in the vial is burst. At activity 10600, the medicament flows from the vial, through the needle, and into a patient. At activity 10700, once a predetermined dose is expelled and/or injected, the needle is withdrawn from the patient and/or retracted into the pre-use bounds of the apparatus. At activity 10800, the apparatus is rendered unusable for additional injections and/or indicated as previously utilized.
[160] FIG. 11 is a perspective view of an exemplary embodiment of system 1000, showing actuation guard 1200 removed from housing 1100, so that actuation guard 1200 no longer separates actuator bar 1300 from handheld portion 1800.
Actuation guard 1200 can comprise a grippable portion 1220 that can be gripped by a user to pull actuation guard 1200 away from housing 1100, thereby allowing system 1000 to be activated, such as via slapping actuator bar 1300 against a thigh of the user. Actuation guard 1200 can comprise an actuation stick separator portion 1240, that can keep separate actuation stick prongs 2240 when actuation guard 1200 is installed on housing 1100.
Actuation guard 1200 can comprise a guard portion 1260 that can separate actuator bar 1300 from handheld portion 1800 when system 1000 is not in use and/or when system 1000 has not been used.
[161] FIG. 12 is a perspective cross-sectional view taken along lines B-B of FIG.
11, and FIG. 13 is a perspective view of an exemplary embodiment of actuation stick 2200. Referring to FIGs. 12 and 13, system 1000 can comprise housing 1100, actuation bar 1300, and system actuator 2000, which can comprise prong squeezer 1390, actuation stick 2200, prong retainer 2100, spring 2300, upper spring retainer 2260, gas container 2400, gas port 2600, and/or puncturer 2700. When actuation bar 1300 is pressed firmly against a user's body, such as via slapping housing actuation bar against the user's thigh, buttocks, and/or arm, prong squeezer 1390 can urge prong tips 2220 of prongs 2240 of actuation stick 2200 toward one another. Note that prong tips 2200 can have a triangular, wedge, angular, and/or frustro-conical shape. As prongs tips 2220 slide along the angled V-groove of prong squeezer 1390, prong catches 2230 can substantially loose contact with prong retainer 2100.
This can allow compressed spring 2300 to rapidly urge actuation stick 2200 and gas container 2400 toward puncturer 2700, which can penetrate gas port 2600, thereby allowing gas to escape from gas container 2400. Although any of many different types of gas containers can be utilized, an exemplary gas container can be obtained from Leland Limited, Inc. of South Plainfield, NJ.
[162] FIG. 14 is a cross-sectional view of an exemplary embodiment of gas venting mechanism 8000 of system 1000 taken along lines A-A of FIG. 3. System 1000 can comprise handheld portion 1800, actuator bar 1300, sleeve 1500. As pistons 4440 near the limit of their travels, medicament 5200 can be expelled along medicament path 5900, which can extend past frangible 5300, through medicament channels 9200, medicament conduit 9300, and needle 6100, and into the body of a user, such as subcutaneously, intramuscularly, and/or at a depth of from approximately 0.25 millimeters to approximately 20 millimeters, including all values and subranges therebetween, such as up to 2 millimeters, greater than 5 millimeters, etc.
[163] As pistons 4440 near the limit of their travels, engagement of gas release actuator 9700 with gas release valve 8200 can cause compressed spring 8300 to move valve arm such that o-ring 8400 is urged away from its seat 8500.
This movement can reveal a passage 8600, via which gas can exit gas chamber 3200 along gas exhaust path 8900, which can extend between sleeve inner walls 1520 and outer walls 9100 of medicament carrier 9000. Eventually, gas exhaust path 8900 can extend between handheld portion 1800 and actuator bar 1300. Likewise, an alternative embodiment of valve 8200, made of rubber or any other resilient material, can be placed across seat 8500 to provide a seal that, once gas release actuator 9700 interacts with valve 8200, allows valve 8200 to bend or flap upwards away from seat 8500, causing the gas to escape via passage 8600.
[164] The following paragraphs expands on the above and describe various exemplary embodiments relating to compact auto-injectors that can comprise and/or utilize a vial or a plurality of vials to store and/or contain an injectable medicament. These auto-injectors can have a compact form factor, such as approximately the size of a credit card. There are many methods of delivering such medicaments in such compact devices. The below descriptions cover multiple methods and/or mechanisms that can effectively administer a medicament using a compact auto-injector.
Exemplary Embodiment One: Methods of Utilizing an Auto-injector [165] This exemplary embodiment describes a method of implementing an auto-injector utilizing a spring and/or gas driven system to administer a medicament and/or comprises a needle protection system.
[166] An embodiment for delivering medicament from a chamber can comprise a vial or plurality of vials; said chamber in communication with a needle that can be concealed initially by some shield and/or sheath; extending said needle from the sheath at least lmm and/or inserting the needle past a needle insertion point to an injection site at a depth of at least 5mm; the application of a force that can originate from the contents of a gas cylinder and/or by means of a spring or multiple springs sufficient to eject medicament held within said chamber into the needle and/or through the needle insertion point to a depth of at least 5mm to deliver up to 5 ml of medicament into the injection site in less than 5 seconds; wherein the medicament can be injected and/or held through the use of a vial system that comprises a plunger, vial(s), reservoir, and/or needle that can be located within said chamber; wherein the force can be applied on the plunger at the proximal end allowing for the plunger, vial(s), reservoir, and/or needle to travel towards the distal end of the housing;
wherein the plunger can slideably travel through the vial towards the distal end to allow for the appropriate dose of medicament to be delivered; wherein the needle insertion point can be located more superficial than the injection site; wherein the needle can have a length of at least 6mm and/or the medicament can be ejected at a pressure of at least 25 p.s.i. at a rate of at least 0.20 ml/sec; and/or wherein the needle can retract into the shield and/or housing and/or a needle protection portion slides over the needle following delivery of the medicament.
[1] FIG. 15 shows an exemplary embodiment an auto-injector 15000. Though the figure shows the force mechanism used as being compressed gas, the force method can be created by a spring force (See description of FIG. 18 below).
The top of the housing can be laser-welded to ensure stability due to high pressure. Likewise, the entire housing may be made smaller by eliminating screws and/or pins holding the base and/or top to the housing. In FIG. 15, this can be completed by adding hooks to the base. The hooks can allow the base to slide into the housing, thus pushing the detents inward and allowing for the puncturing of the gas cylinder by the compressed spring. These hooks can also click into the housing, making the base unable to move post-injection; this eliminates re-use of the device and acts as an indicator to determine if the device has been used or if the device has not been activated. The gas release mechanism is also a novel addition to the device. A rubber flap and/or other resilient material can be located inside the plunger bar. A solid piece or member can stick up from the reservoir near the top of the vials. Once the plunger bar dispenses the medicament, this piece can push the rubber flap up, thereby releasing excess gas in the system. The puncturing device for the gas cylinder could be a roll-pin that is sliced at a 45 degree angle to ensure sharpness for puncturing.
[167] FIG. 16 shows the safety tab used to protect the user from accidental activation. FIG. 16 also shows an extended portion of the safety tab with grooves added to it. This can aid the user in removing the safety tab by creating a larger gripping surface and/or a more tactile feel to the tab.
Exemplary Embodiment Two: Chemical Reaction [168] This exemplary embodiment involves an auto-injection system that utilizes a chemical reaction as an activation mechanism to deliver the medicament into a patient. It also comprises a needle protection system.
[169] This exemplary embodiment comprises a delivery system that can encompass a housing, vial or plurality of vials, plunger for each vial, single needle or needle cannula, and medicament or medicaments within the vial or plurality of vials; the vial or plurality of vials in communication with the plunger(s) at proximal end and in communication with a reservoir that contains a single needle or needle cannula at the distal end; the needle can be protected by some sheath/ shield; a chemical reaction capable of occurring when one chemical is allowed to interact with another chemical and/or a substance that may create such a reaction through the use of some activation mechanism; and said chemical reaction that can generate a force that is strong enough to drive said plunger, vial, reservoir, and needle towards the distal end of the housing;
the needle exiting said sheath/shield and entering an injection site; the plunger(s) slideable in the vial(s) that contain the medicament; and said medicament exiting the vials into through the reservoir and needle cannula into the injection site; upon exit of the desired contents of the vial, the entire needle, reservoir, vial, and plunger assembly can retract towards the proximal end of housing by some means such as a wire, spring, o-ring, and/or rubber membrane and/or a needle protection portion slides over the needle following delivery of the medicament.
[170] FIG. 17 is a view of the compact injector with several modifications to allow for a chemical reaction to occur as the primary force method in order to deliver the 'medication. In the particular drawing, the puncturing pin can include a rough surface. Likewise, the container used in the device can have a similar rough material and/or surface and can contain mostly Sodium Azide (NaN3). Once the spring (attached to the container) is activated, the two rough surfaces can simultaneously come in contact with each other to create a spark and puncture the Azide container. This can create an immediate chemical reaction because of the spark. The reaction (2 NaN3 -> 2 Na + 3 N2) can form hot nitrogen gas and sodium in order to create enough force to inject the medication. A modification to this figure can be made to include another container at the top in place of the puncturing pin that can break open from the force of the spring and second container, thus mixing the two chemicalss and can cause a chemical reaction to occur in order to produce the force needed.
Exemplary Embodiment Three: The Spring Driven Injector [171] Certain exemplary embodiments of the auto-injector can use a spring or multiple springs to inject the medicament into a patient. The novelty of this system can lie in the orientation of the activation springs and the vial system (that comprises the plunger, vial(s), reservoir and the needle/cannula) system.
Because the activation springs can be located in parallel to the vial system, the device can be smaller than existing devices on the market (that are linear in nature), potentially having a form factor that is approximately the size of a credit card.
[172] Certain exemplary embodiments can comprise a delivery system that can encompass a housing, vial or plurality of vials, plunger for each vial, single needle or needle cannula, and medicament and/or medicaments within the vial or plurality of vials; the vial or plurality of vials in communication with the plunger(s) at proximal end and in communication with a reservoir that contains a single needle or needle cannula at the distal end; the needle protected by some sheath/ shield; the housing further comprising at least one spring (this can comprise a gas spring, coil spring, leaf spring, etc.) wherein the spring(s) is parallel to the plunger, vial(s), and reservoir system and is in communication with a solid member (that can be made of rubber, plastic, metal, and/or some other resilient material) that is also in communication with the proximal end of the plunger such that when the spring(s) is activated, a force is applied on the plunger at the proximal end allowing for the plunger(s), vial(s), reservoir, and needle to travel towards the distal end of the housing;
wherein the plunger can slideably travel through the vial towards the distal end to allow for the appropriate dose of medicament to be delivered; the solid member is displaced away from the plunger, which can allow for the retraction of the entire needle, reservoir, vial(s), and plunger assembly towards proximal end of housing by some means such as a wire, spring, o-ring, and/or rubber membrane and/or for a needle protection portion to slide over the needle following delivery of the medicament.
k [173] FIG. 18 shows several views of the spring driven injector. The primary force used to push down the pusher bar, vial system, reservoir, and needle can be provided by compressed springs. In the cross-section drawing, two springs can be located on the outside of the central chamber (containing the pusher bar, vials, reservoir, and needle). The springs can be held in place by a rod coupled with hooks. Each spring can have a rolling solid member attached to it that is also connected to a bar that is held into a notch/indentation in the reservoir near the bottom of the vials. Furthermore, a solid beam can wrap around the top of the pusher bar and can attach to the aforementioned bar. The bar can slide in and out of the reservoir and the solid beam, but only if the rolling solid member is rolled away from the reservoir and beam. The device can be activated by the user pulling out the safety mechanism and pushing downward on the outside sleeve. This can cause the hooks from the rods holding the springs in place to pinch inward, thereby releasing the springs forcefully downward. As the springs are driven downward, the rolling solid member and bar can roll down through the solid member passage. As the rolling solid member is moved, the solid beam wrapped around the pusher bar can come down as well, pushing the needle into the user. The medication can then be delivered into the user and/or patient once the rolling solid member goes down even further, which can be continually driven by the force of the springs. The solid member passage eventually can turn away from the vial system and reservoir (also shown in the side view drawing as a hidden line).
This can slide the bar out of the reservoir and out of the beam, allowing for the retracting springs to push the pusher bar, vials, reservoir, and needle back into the housing.
Exemplary Embodiment Four: Pulley System [174) This exemplary embodiment can utilize a pulley system as the activation mechanism for injecting medicament into the patient and that can also comprise a needle protection system.
[175] Certain exemplary embodiments can comprise a delivery system that can encompass a housing, vial or plurality of vials, plunger for each vial, single needle or needle cannula, and medicament or medicaments within the vial or plurality of vials; the vial or plurality of vials in communication with the plunger(s) at proximal end and in communication with a reservoir that can contain a single needle or needle cannula at the distal end; the needle that can be protected by some sheath/ shield; the housing further comprising one or more spring pulley system(s) that can constitute a spring connected to some slideable resilient.material such as a string, wire, wire coil, flat metallic band, etc. at the proximal end of the housing, and said material that can travel through a channel in the housing from the proximal end of the housing towards the distal end of the housing and then returning through a parallel channel towards the proximal end wherein this material is connected to a solid member (made of rubber, plastic, metal, and/or some other resilient material);
the solid member in communication with the proximal end of the plunger such that when the spring is activated the spring can produce enough force to allow the pulley system to operate by having the resilient material, such as a cord, which can forcefully travel towards the proximal end of the housing and can cause the cord to move the solid member in communication with the plunger, vial(s), reservoir, and/or needle towards the distal end; wherein the needle can exit said sheath/shield and can enter an injection site; the plunger(s) slideable in the vial(s) that can contain the medicament; and said medicament can exit the vials into through the reservoir and/or needle cannula into the injection site; upon exit of the desired contents of the vial, the solid member can be displaced away from the plunger allowing for the entire needle, reservoir, vial(s), and/or plunger assembly to retract towards the proximal end of housing by some means such as a wire, spring, o-ring, and/or rubber membrane and/or a needle protection portion to slide over the needle following delivery of the medicament.
[176] A pulley system is shown in FIG. 19 as the primary method for forcing the pusher bar, vials, reservoir, and needle down for medicament injection.
Similar to the above spring-driven injector, the activation springs can be located parallel to the vial system and the device can be activated by the user pushing down on the outside sleeve of the device. The use of a pulley system can create a mechanical advantage, producing the proper force needed to efficiently push down the vial system and deliver the proper dose of medication. FIG. 19 shows a bar that can be connected to the end of the rod/spring member. This bar can be connected to the pulley system (that can comprise some resilient and/or moveable material). The other end of the pulley system can be connected on top of the pusher bar to a beam that can be able to slide when moved to a certain position. As the springs are driven downward, the pulley system can pull the pusher bar, vials, reservoir, and needle down as well. Similar to the spring-driven injector, the solid beam member on top of the pusher bar can slide down the solid member passage and eventually dislodge from the pusher bar. Once this occurs, the entire system can retract back within the housing due to the force from the retracting springs.
Exemplary Embodiment Five: The Needleless Injector [177] This exemplary embodiment can comprise a Needleless Injector that can be gas and/or spring activated and that can allow for a user to inject a medicament into a patient without the use of a needle. The use of a plurality of vials can be considered the novel component and can allow the device to be compact in nature, such as having the approximate length and width similar to that of a credit card.
[178] Certain exemplary embodiments for delivering medicament from a chamber can comprise a plurality of vials; the said chamber in communication with a passage into a small injection opening; the application of a force that can originate from the contents of a gas cylinder and/or by means of at least one spring that can eject medicament held within said chamber into the passage to the small injection opening, which can be defined and/or created by the housing and/or a small sterile rod that can be a needle or cannula allowing for the slight puncturing of the injection site in order to allow the medicament to be delivered, and through the tip of this small injection opening to a depth of at least 1mm, that can deliver up to 5 ml of medicament into the injection site;
wherein the medicament can be injected and held through the use of a vial system that comprises a plunger, vial(s), and/or reservoir all located within said chamber; wherein the force can be applied on the plunger at the proximal end allowing for the plunger, vial(s), and/or reservoir to travel towards the distal end of the housing; wherein the plunger can slideably travel through the vial towards the distal end to allow for the appropriate dose of medicament to be delivered through the reservoir into the small injection opening; wherein the injection opening point can be located more superficial than the injection site; wherein the medicament can be ejected at a pressure of at least 25 p.s.i.
(For example, in such embodiments, the pressure to deliver a dose of 0.5cc's could be about 100 pounds of force).
[179] FIG. 20 depicts the components of the needleless injector. The injector can be activated by removing a safety tab and pushing down on the housing. The rod with hooks holding the spring in place can be initiated by the base moving upwards and pushing the hooks inward. The spring can drive the high pressure gas cylinder into a puncturing pin, releasing the gas cylinder contents.
The gas cylinder contents can push down the pusher bar, vials, and reservoir into the small opening at the base of the device near the injection site. A
tiny cannula and/or needle can be located at the bottom of the reservoir and/or can be used for slightly puncturing the injection site. This slight puncture can allow the medicament stored in the vial to flow through the reservoir and into the injection site. Once the pressure is released, the entire system (including the pusher bar, vials, and reservoir) can be pushed back up within the housing by the retracting springs.
Exemplary Embodiment Six: The Multi-Pharmaceutical Injector [180] This exemplary embodiment can comprise a compact auto-injector that can incorporate a plurality of vials, allowing for multiple medicaments to be injected at one time or at different times. The use of a plurality of vials can be considered the novel component and also can have the advantage of creating a device that is compact in nature, such as one having the length and width of a credit card. The device also can comprise a needle protection system.
[181] Certain exemplary embodiments for delivering medicament from a chamber can comprise a plurality of vials; the said chamber or chambers in communication with a needle or needles that can be concealed initially by shields and/or sheaths; that can extend said needle from the said sheath at least lmm and can insert the needle past a needle insertion point to an injection site at a depth of at least 5mm; the application of a force and/or forces that can originate from the contents of a gas cylinder and/or multiple gas cylinders, and/or by means of a spring and/or springs sufficient to eject medicament held within said chamber into the needle and through the needle insertion point;
wherein the medicament can be injected and held through the use of a vial system and/or vial systems that can comprise a plunger, vial, reservoir, and/or needle all located within said chamber(s); wherein the force can be applied on the plunger at the proximal end allowing for the plunger, vial, reservoir, and/or needle to travel towards the distal end of the housing; wherein the plunger can slideably travel through the vial towards the distal end to allow for the appropriate dose of medicament to be delivered; wherein the needle insertion point can be located more superficial than the injection site. The device potentially having a multitude of said components (including but not limited to vials, plungers, gas cylinders, springs, needles, reservoirs, sheaths, shields, chambers, and/or retracting springs) in order to administer multiple medicaments into a patient at one time and/or at different times, as one dose and/or in multiple doses, depending on when each individual system is activated. The device can have selectors and/or other mechanisms to allow the user to choose which medicament to administer. Each individual system can comprise an activation mechanism (such as a spring and/or gas cylinder), a chamber within said housing, and a plunger, vial, reservoir, needle, and/or retraction spring; wherein upon exit of the desired contents of the vial, the entire needle, reservoir, vial, and/or plunger assembly retracts towards the proximal end of housing by some means such as a wire, spring, o-ring, and/or rubber membrane and/or a needle protection portion slides over the needle following delivery of the medicament.
[182] A method for administering multiple pharmaceuticals is depicted in FIG.
21.
The injector can include medicament selectors in order to allow the user to select which medicament to inject. The user can select the medicaments by sliding one or more selectors upward into their final position. An audible click or some other indicator may occur to alert the user to this final position.
Moving the selector or multiple selectors upwards can allow a pin to snap into the plunger rod and/or into the pusher bar, which can create an entire portion that can push the vial system downwards and can inject the medication through the vial, the reservoir and/or needle. (This method can also be used with the Needleless injector method as described earlier in this document) Methods such as this embodiment could be extremely useful in applications for anti-nerve agents or pain therapies. The device can also include a resilient material, such as rubber, to seal the selector openings and that can also slide within the housing once the selector is pushed upward. Once the aforementioned pins are in place, the device can function and activate similarly to that described above. A safety mechanism can be modified to eliminate the sliding selectors from being prematurely pushed upwards.
Exemplary Embodiment Seven: The WetlDry Injector [183] This exemplary embodiment can comprise a compact auto-injector that can have the ability to mix two or more medicaments in either a liquid or powder form to create one injectable medicament. The novel component of this device can be considered to be the use of a plurality of vials to deliver the medicament. The device also can comprise a needle protection system.
[184] An exemplary delivery system can comprise a housing, plurality of vials, plunger for each vial, a mixing activation mechanism, an activation chamber or vial, single needle or needle cannula, and/or a medicament or medicaments stored within each vial. Pre-injection, two or more medicaments can be stored separately in a vial and/or storage compartment and can communicate with each other once the mixing activation mechanism is initialized. The mixing activation mechanism could comprise a button, trigger, threaded rod, and or some other member that removes a piece or portion and/or punctures a piece or portion that is preventing each medicament to communicate with each other. The mixing activation mechanism may comprise a membrane, piece, and/or portion that may be removed pre-injection by the user in order to allow the separate vials and/or storage containers to communicate with each other.
The mixing activation mechanism can be a piece that is manipulated in some way by the user in order to cause the contents of each compartment to mix with each other. This communication may occur by shaking the device and/or may occur automatically with the mixing activation mechanism. For instance, the mixing activation mechanism may cause each medicament to be released into an activation chamber, which may itself be a separate vial. This mixed medicament can be the medicament that will be injected into the patient. The delivery system further encompassing the mixed medicament vial or plurality of mixed medicament vials in communication with the plunger(s) at the proximal end of the housing and in communication with a reservoir that can contain a single needle or needle cannula at the distal end; the needle can be protected by some sheath/ shield; the housing can further comprise a passage that is also in communication with the proximal end of the plunger such that when the spring(s) is activated from the distal or proximal end, a force can be applied through the passage on the plunger at the proximal end allowing for the plunger(s), vial(s), reservoir, and/or needle to travel towards the distal end of the housing; wherein the force provided can be caused by a spring, bar, contents from a gas cylinder, and/or other force mechanism; wherein the plunger can slideably travel through the vial towards the distal end to allow for the appropriate dose of medicament to be delivered; upon exit of the desired contents of the vial, the entire needle, reservoir, vial, and/or plunger assembly can retract towards the proximal end of housing by some means such as a wire, spring, o-ring, and/or rubber membrane and/or a needle protection portion slides over the needle following delivery of the medicament.
[185] FIG. 22 depicts a novel method for injecting lyophilized medications, and/or powdered biologics that could need to be reconstituted pre-injection. FIG. 22 shows a mechanism to mix and/or create an injectable medicament from two or more separate aforementioned substances. The figure depicts multiple vials that could have two substances in each vial separated by a pierceable membrane and/or other frangible piece. The vials in this embodiment can have one wet substance (such as sterilized water) and one dry substance (such as glucagons powder). The user can take off the safety tab which can prevent the user from accidental injection and/or pre-mature activation of the device.
Once the safety device is removed, the user can twist and/or rotate the twisting portion at the top of the housing. By rotating this top portion, the rods attached to this portion (which can be threaded rods) can move downward. These rods can be located in the vials and/or through the pusher bar. The rods can have a sharp piercing portion on the distal end which can aid in puncturing the aforementioned pierceable membrane that can separate the substances in the vial. Once the piercing rod punctures the frangible and/or pierceable membrane, the substances can mix together to form one medicament. The user can also shake the entire housing in order to aid in this mixing process.
Exemplary Embodiment Eight: Needle End Safety System [186] Certain exemplary embodiments can comprise a safety system that can allow a user to remove some cap, bar, lock at the same end of an auto-injector housing where the needle is located. This can allow the device to be ready for activation while still protecting the needle at the same time. Many auto-injectors, such as most pen-like injectors, have the activation safety mechanism on the opposite end of where the needle is located. In an emergency situation, the user may mistake this safety cap as protecting the needle, when in fact this is not the case. There have been many documented cases of digital injection into a user's thumb or finger because of this reason.
Having the safety mechanism at the same end of the needle can eliminate this risk.
Exemplary Embodiment Nine: Auto-injector with Feedback [187] The use of auto-injectors and drug delivery systems is common in the medical industry. Auto-injectors can deliver a range of medicaments into a patient, ranging from chronic therapies to critical care injectables. As more therapies are developed, the need for a vehicle to deliver these therapies is ever-increasing. Certain auto-injectors currently on the market can lack attributes that can allow the user to understand the device's functionality and/or operation. Thus, there is perceived a need for an auto-injector that can provide audible, haptic, and/or visual feedback to the user in order to effectively train and/or guide the user on how to properly operate the auto-injector and/or to mitigate user-related hazards that could occur when the device is not used correctly.
[188] The incidence of use-related hazards associated with auto-injectors is increasing. Common problems associated with certain injectors on the market include poor design, sharps exposure, and poor instruction. Many auto-injectors on the market are in the form of an apparatus that resembles a pen or marker. The safety mechanism for most of these devices can cause patient confusion as it is often protecting the activation mechanism and not the location where the needle protrudes out of the device. There have been numerous cases of the user accidentally injecting the needle into their own thumb or finger because of this hazard. Examples of devices that incorporate this design can include certain pen-type auto-injectors for allergic emergencies, and/or certain anti-nerve agent auto-injectors currently supplied to both domestic and foreign militaries. These devices, and most auto-injectors on the market, also can allow the needle to remain protruding out after use, thereby potentially causing a post-injection sharps hazard.
Further, many of these injectors exhibit poor instruction and/or labeling. Due to the cylindrical design of certain auto-injectors, the surface area for labeling can be small, rounded, and therefore can prevent a user from easily reading important information regarding the use of the device. For many injectors that are used in emergency situations, it can be important that the user be able to use the device correctly and efficiently. The user might not take or have time to read the instructions on the device during such a critical scenario.
[189] For one or more of these reasons, an interactive auto-injector or medical device is described that can provide a user with visual, haptic, and/or audible feedback in order to mitigate the aforementioned risks and/or to allow for easy injection of medications.
[190] Certain exemplary embodiments can provide an interactive auto-injector and/or a method of providing audible, haptic, and/or visual feedback to a user when operating the auto-injector. An auto-injector can be defined as any device that allows a user to deliver a medicament without having to manually prepare the injection. This can include pen delivered injectors, syringes, needleless injectors, gas powered auto-injectors, and/or any other auto-injector and/or medical device used to inject a pharmaceutical into a user/patient, etc.
[191] Certain exemplary embodiments can provide an auto-injector that can comprise an information device and/or system comprising at least one sensor (e.g., a pressure sensor, proximity sensor, tactile sensor, and/or biometric input device, etc.), switch (e.g., gate switch, microswitch, and/or pushbutton, etc.), embedded system (e.g., microprocessor, memory, embedded operating system, system bus, input/output interface, and/or network interface, etc.), audible output sub-system (e.g., speaker, horn, buzzer, and/or piezoelectric transducer, etc.), visual output sub-system (e.g., flag, marker, light, liquid crystal display (LCD), light emitting diode (LED), optical fiber, organic polymer display, electric paper, screen, display, monitor, and/or tube, etc.), haptic output sub-system (e.g., buzzer, vibrator, bulging portion, tactile stimulator, cooler, and/or heater, etc.), and/or any other component and/or sub-system that would aid in providing audible, visual, and/or haptic feedback to a user of the auto-injector, along with appropriate circuitry, control system(s), housing(s), shielding, electrical conductors, and/or power source(s), etc.
[192] Certain embodiments of auto-injectors can comprise a housing, safety mechanism, activation mechanism (such as a spring means or compressed gas cylinder), a vial or container for storing the medicament, and a needle for delivering the medicament. Certain exemplary embodiments can provide one or more audible, visual, and/or haptic outputs to guide and/or instruct the user how to use the auto-injector properly. Sensors and/or switches can be placed on the safety tab, on the bottom of the device where the needle comes out, and/or where the inner sleeve slides up to activate the device. Visual outputs can be placed at each of the aforementioned locations as well and/or instead.
An audible output sub-system can be placed anywhere on the device for audible feedback. A haptic output sub-system can be placed anywhere on the device. These electronically-triggered and/or active components and/or sub-systems can be incorporated into the labeling of the device and/or as a separate component to provide this visual, haptic, and/or audible feedback.
[193] For example, the user can push a button or switch on the device to initiate the audible, haptic, and/or visual output sub-system. A pre-recorded audible voice can tell the user to pull up on the safety tab, while a visual and/or haptic output can be rendered on the safety tab to provide a visual and/or haptic clue to the user as to where the safety tab is located. Once the safety tab is pulled up correctly, a sensor or switch could trigger the next step for the voice to announce, for example, asking the user to place the base of the device on the outer portion of their thigh while also triggering a visual output to light the base of the device. By way of further example, the user can be provided a visual clue in which at least a portion of the base of the device is lighted and/or colored red, and/or the user can be provided a haptic clue in which the base on the device is moved and/or the base is heated sufficiently (such as to between approximately 105 degrees F and approximately 120 degrees F, including all values and sub-ranges therebetween) to substantially warm, yet not burn, the user's skin. The embedded operating system, which can run in hard real-time to avoid delays that might be significant and/or life-threatening, can also recognize a failure to complete a step in a certain specific timeframe and cause the step to be repeated if necessary and/or provide negative feedback if the user fails to perform a step properly (e.g., via input from a sensor or switch, the operating system can timely notice that the device is not placed on the skin of the thigh correctly and can cause the audible output sub-system to tell the user to repeat the placement step). Once the user places the device on the thigh properly, the sensor or switch could trigger the next audible, visual, and/or haptic clue and/or output, such as asking the user to push down on the outside sleeve of the device with force. By instructing the user step-by-step through each task, user error and/or risks of certain hazards can be reduced and/or eliminated.
[194] Certain exemplary embodiments can provide a compact, credit card-sized auto-injector used to deliver a variety of medicaments, such as pharmaceuticals and/or agents. Though this auto-injector can eliminate many problems associated with certain pen-style auto-injectors, such as the sharps hazard and/or the poor safety tab design, there can be a need for an interactive auto-injector in order to aid in user instruction of the device and/or to help ensure the device is used properly any and/or every time it is needed. The following, and the attached figures, further describes such an auto-injector.
[195] FIG. 23 portrays an auto-injector having a housing similar to the length and width of a credit card, an activation mechanism on one side and a vial system non-coaxial with the activation mechanism. The activation mechanism can comprise a compressed spring and compressed gas cylinder used as the force mechanism, and a puncturing mechanism to dispel the contents of the compressed gas cylinder. A vial system can be comprised of a pusher bar, plungers, vial(s)/medicament storage container(s), a reservoir, a needle, and a needle sheath. Retraction springs located at the base of the reservoir can push the needle back within the housing after injection. A slideable base can be used to activate the activation mechanism, which can be transparent to show the location of the aforementioned needle. A safety tab can be located between the base and the housing and/or can keep the activation mechanism from being activated while protecting the user from the needle. Sensors and/or switches, which can help trigger audible, haptic, and/or visual feedback, can be located on the base and/or on the safety tab. A button and/or switch, which can help trigger audible, haptic, and/or visual feedback sub-system(s), can be located on the housing. The feedback sub-system(s) can be activated based on inputs received and/or interpreted by the embedded operating system.
[196] For example, an audible output sub-system located in the housing can provide audible feedback to the user of the device. The audible output sub-system can be comprised of one or more piezoelectric transducers, small and/or large cones and/or speakers, sensors, capacitors, memories, power sources (e.g., battery, fuel cell, spring-actuated generator, etc.) housing, wires, and any other electronic components needed to provide recorded audible feedback to a user.
The audible output sub-system can be activated by the aforementioned button or switch on the housing. The speaker can provide instructions for how the device is used and/or certain medication requirements.
[197] As another example, visual outputs can be located throughout the device, and/or on the base, safety tab, labeling, and/or housing to provide visual clues to the user. These visual outputs can be activated by the operating system once a sensor or switch is triggered. An LCD, optical polymer, LED, electric paper, and/or other form of display, monitor, and/or screen and/or other visual output can provide data to the user such as dosage amount, expiration date, instructions, Federal Drug Administration (FDA) requirements, and/or other labeling requirements, etc.
[198] Referring to FIGS. 24 and 25, the user can push the button on the housing to, via the embedded processor, activate the audible, haptic, and/or visual feedback sub-system on the auto-injector. For example, a voice from the audible output sub-system (now activated) can provide an audible message to the user, such as "Please remove the safety tab." The safety tab can also light up from visual outputs located on the safety tab. Once the safety tab is removed, a sensor can be triggered that can also trigger the next audible task from the audible output sub-system. If the safety tab is not removed within a certain timeframe, the first voice response can be repeated. The button or switch can be pressed several times or held in order to stop the process (in case the injector does not need to be used or the button was pressed accidentally). After the safety tab is removed, the next audible clue can be annunciated, such as "Please place the base of the device on the outer portion of your thigh." The base can simultaneously light up during this audible clue, providing a visual clue that demonstrates where the base is located and/or what portion of the base should be placed on the thigh. A sensor or switch, located on the base, can be used to help determine if the auto-injector is placed correctly on the injection site. The same switch and/or sensor, and/or another switch and/or sensor located on the base can help trigger the next audible message, such as "Push down on the top of the device to activate the injector."
That switch and/or sensor can also trigger one or more visual outputs to light up the labeling and/or an arrow pointing down toward the injection site (as shown in FIG. 24).
[199] Certain exemplary embodiments can comprise a compact auto-injector that can have the ability to mix two or more medicaments, agents, solutes, solvents, etc., in either a liquid or powder form and/or create one injectable medicament. Certain exemplary embodiments can include an interactive system that can provide haptic, audible, and/or visual feedback to provide the user with instructions, hints, and/or clues in order to use the device properly.
The auto-injector also can comprise a needle protection system.
[200] An exemplary delivery system can comprise a housing, plurality of vials, plunger for each vial, a mixing activation mechanism, an activation chamber or vial, single needle or needle cannula, and/or a medicament or medicaments stored within each vial, etc. Prior to injection, two or more medicaments can be stored separately in a vial and/or storage compartment and can fluidically communicate with each other once the mixing activation mechanism is initialized. The mixing activation mechanism can comprise a button, trigger, threaded rod, and or some other member that removes a piece or portion and/or punctures a piece or portion that is preventing each medicament from communicating with each other. The mixing activation mechanism can comprise a membrane, piece, and/or portion that can be removed pre-injection by the user in order to allow the separate vials and/or storage containers to fluidically communicate with each other. The mixing activation mechanism can be a piece that is manipulated in some way by the user in order to cause the contents of each compartment to mix with each other. This communication can occur by shaking the device and/or can occur automatically with the mixing activation mechanism. For instance, the mixing activation mechanism can cause each medicament to be released into an activation chamber, which may itself can be a separate vial. This mixed medicament can be the medicament that will be injected into the patient.
[201] The delivery system can comprise the mixed medicament vial or plurality of mixed medicament vials in mechanical and/or fluid communication with the plunger(s) at the proximal end of the housing and in mechanical and/or fluid communication with a reservoir that can contain a single needle or needle cannula at the distal end. The needle can be protected by a sheath and/or shield. The housing can comprise a passage that is also in mechanical and/or fluid communication with the proximal end of the plunger such that when the spring(s) is activated from the distal or proximal end, a force can be applied through the passage on the plunger at the proximal end allowing for the plunger(s), vial(s), reservoir, and/or needle to travel towards the distal end of the housing. The applied force can be caused by a spring, bar, contents from a gas cylinder, and/or other force mechanism. The plunger can slideably travel through the vial towards the distal end to allow for the appropriate dose of medicament to be delivered. Upon exit of the desired contents of the vial, the entire needle, reservoir, vial, and/or plunger assembly can retract towards the proximal end of housing by some means such as a wire, spring, o-ring, and/or rubber membrane and/or a needle protection portion slides over the needle following delivery of the medicament.
[202] The interactive system can comprise a speaker sub-system that can comprise piezos and/or other components to produce audible sounds and/or human voice; a haptic sub-system that can provide haptic feedback to the user; a visual sub-system that can comprise light emitting diodes, LCD's, optical fibers, and/or other components that can produce visual outputs such as light and/or color; a processor that can be used to control the activation of such components; a power source such as a battery that can power the aforementioned interactive system; and/or switches, buttons, and/or sensors that can activate certain visual, haptic, and/or audible clues at a particular moment.
[203] FIG. 25 depicts a novel method for injecting lyophilized medications, and/or powdered biologics that might need to be reconstituted pre-injection. FIG. 25 shows a mechanism to mix and/or create an injectable medicament from two or more separate aforementioned substances. FIG. 25 depicts multiple vials that can have, for example, at least two substances in each vial separated by one or more pierceable membranes and/or other frangible pieces. The vials can have at least one wet substance (such as sterilized water) and at least one dry substance (such as glucagon powder). The user can take off the safety tab, which can prevent the user from accidental injection and/or pre-mature activation of the device. Once the safety tab and/or device is removed, the user can twist and/or rotate the twisting portion at the top of the housing.
By rotating this top portion, the rods attached to this portion (which can be threaded rods) can move downward. These rods can be located in the vials and/or through the pusher bar. The rods can have a sharp piercing portion on the distal end which can aid in puncturing the aforementioned pierceable membrane(s) that can separate the substances in the vial. Once the piercing rod punctures the frangible and/or pierceable membrane(s), the substances previously separated thereby can mix together to form one medicament. The user can also shake the entire housing in order to aid in this mixing process.
[204] The device can include an electronic/interactive system to provide visual, haptic, and/or audible feedback to the user. This interactive system can include a microprocessor to control the specific feedback components, a speaker sub-system, a haptic sub-system, a sub-system of switches and/or sensors, a sub-system of LEDs or optics, a battery power source, and any other component needed to produce audible or visual outputs. Figure 4 portrays these components located throughout the device; however, the actual placement of these components is flexible. The user can activate the interactive system by pushing a button or switch located on the housing of the device. This button or switch can activate the processor which can then send signals to the audible output sub-system, haptic output sub-system, and/or visual output sub-system.
The audible output sub-system can provide an audible clue for the initial task, which can be in the form of a human, humanesque, and/or understandable voice stating, "Please remove the safety tab." A signal can also be sent simultaneously to the safety tab visual output (potentially one or more LEDs) to provide a visual light and/or color clue to the user as to where the safety tab is located. Once the safety tab is removed, a switch or sensor can send a signal to the processor and activate the next audible, haptic, and/or visual clue.
This can be a human voice that states "Please twist the top portion of the injector to activate the mixing mechanism." As with the safety tab, an LED or some other visual clue then can be activated, lighting up the mixing activation mechanism, and/or a haptic clue can be activated, such as vibrating, warming, cooling, bulging, moving, changing a texture of, etc., the mixing activation mechanism. A switch or sensor located near or on the mixing activation mechanism can be used to ensure that the mixing was complete and to trigger the next audible and/or visual clue by the processor. A voice next can state, "Please shake gently to mix the solution." After a certain amount of time, the processor then can send a signal to the audible output sub-system for the next task. This can be a voice that says, "Please place the injector on the outer portion of your thigh." A visual indicator of where the base/injector should be placed also can be simultaneously activated. A switch, sensor, or button then can recognize the correct placement of the device and trigger the next audible and visual clue. This can be a voice stating, "Push down on the top of the injector to activate the injection." Likewise, an arrow or some other visual and/or haptic clue can light up and/or be rendered to show the motion of how the injector should be pushed. The last clue can be an audible clue that states, "Hold in place for several seconds, remove, and dispose of properly,"
indicating that the injection is complete. Additional audible, haptic, and/or visual feedback sub-systems can be used to provide the user with important information such as the expiration of the drug, improper use, and/or error.
For instance, the device's LEDs or optics can blink, a display can render a message, a vibrator can vibrate, and/or an audible beep and/or voice can be activated after a particular time stamp is reached that corresponds to the expiration of the drug and/or device. As another example, once an auto-injector has been used, a message can be displayed describing proper disposal and/or recycling techniques.
[205] FIG. 26 is a block diagram of an exemplary embodiment of an information system and/or device 26000, which in certain operative embodiments can comprise, for example, the interactive, integral, embedded, audible, haptic, and/or visual feedback system, such as described herein. Information system and/or device 26000 can comprise any of numerous components, such as for example, one or more network interfaces 26100, one or more processors 26200 running an embedded, real-time, hard real-time, and/or soft real-time operating system, one or more memories 26300 containing instructions 26400, one or more input/output (I/O) devices 26500, and/or one or more user interfaces 26600 coupled to I/O device 26500, etc.
[206] In certain exemplary embodiments, via one or more user interfaces 26600, such as a graphical user interface, a user can view a rendering of information related to selecting, purchasing, obtaining, operating, maintaining, re-using, and/or disposing of an auto-injector. In certain exemplary embodiments, instructions 26400 can be modified and/or updated via replacing a removable memory 26300 and/or via replacing instructions 26400 (such as, e.g., via flashing an EEPROM, etc.). In certain exemplary embodiments, instructions 26400 can be modified and/or updated via downloading replacement instructions via network interface 26100. System 26000 can comprise a programmable logic controller.
[207] Still other practical and useful embodiments will become readily apparent to those skilled in this art from reading the above-recited detailed description and drawings of certain exemplary embodiments. It should be understood that numerous variations, modifications, and additional embodiments are possible, and accordingly, all such variations, modifications, and embodiments are to be regarded as being within the spirit and scope of this application.
[208] Thus, regardless of the content of any portion (e.g., title, field, background, summary, abstract, drawing figure, etc.) of this application, unless clearly specified to the contrary, such as via an explicit definition, assertion, or argument, with respect to any claim, whether of this application and/or any claim of any application claiming priority hereto, and whether originally presented or otherwise:
[209] there is no requirement for the inclusion of any particular described or illustrated characteristic, function, activity, or element, any particular sequence of activities, or any particular interrelationship of elements;
[210] any elements can be integrated, segregated, and/or duplicated;
[211] any activity can be repeated, performed by multiple entities, and/or performed in multiple jurisdictions; and [212] any activity or element can be specifically excluded, the sequence of activities can vary, and/or the interrelationship of elements can vary.
[213] Accordingly, the descriptions and drawings are to be regarded as illustrative in nature, and not as restrictive. Moreover, when any number or range is described herein, unless clearly stated otherwise, that number or range is approximate.
When any range is described herein, unless clearly stated otherwise, that range includes all values therein and all subranges therein. Any information in any material (e.g., a United States patent, United States patent application, book, article, etc.) that has been incorporated by reference herein, is only incorporated by reference to the extent that no conflict exists between such information and the other statements and drawings set forth herein. In the event of such conflict, including a conflict that would render invalid any claim herein or seeking priority hereto, then any such conflicting information in such incorporated by reference material is specifically not incorporated by reference herein.
Claims
CLAIMS:
1. An apparatus, comprising:
a housing, a distal end surface of the housing defining an opening;
a medicament container disposed within the housing;
a delivery mechanism configured to produce a force to convey a medicament from the medicament container via the opening; and an electronic circuit system including a light output device and a sensor, the sensor configured to produce a signal when the distal end surface is in contact with a body, the electronic circuit system configured to produce a visual output via the light output device in response to the signal produced by the sensor.
2. The apparatus of claim 1, further comprising:
an actuator configured to be manipulated by a user to actuate the delivery mechanism, the visual output configured to illuminate the actuator.
3. The apparatus of claim 1, wherein the sensor is a proximity sensor disposed at the distal end surface of the housing.
4. The apparatus of claim 1, wherein the electronic circuit system includes a speaker, the electronic circuit system configured to produce an audible output in response to the signal produced by the sensor.
5. The apparatus of claim 1, wherein the electronic circuit system includes a speaker, the electronic circuit system configured to produce a recorded speech output in response to the signal produced by the sensor, the apparatus further comprising:
an actuator configured to be manipulated by a user to actuate the delivery mechanism, the visual output and the recorded speech output collectively identifying the actuator.
6. The apparatus of claim 1, further comprising:
a locking member movably coupled to the housing, the locking member configured to engage a portion of the delivery mechanism to limit movement of the delivery mechanism, the electronic circuit system including a switch operably coupled to the locking member such that the locking member actuates the switch when the locking member is moved, the electronic circuit system configured to produce an electronic output when the locking member actuates the switch.
7. The apparatus of claim 1, further comprising:
a needle configured to be in fluid communication with the medicament container, the delivery mechanism configured to move the needle between a first position and a second position, in the first position the needle is contained within the housing, in the second position a portion of the needle extends from the housing via the opening, the delivery mechanism including an energy storage member having a longitudinal axis offset from a longitudinal axis of the needle.
8. The apparatus of claim 1, wherein the light output device is any one of a light-emitting diode, a liquid crystal display, an organic polymer display or a fiber optic display.
9. The apparatus of claim 1, wherein the medicament is any one of a medicine, medication, drug, pharmaceutical, prescriptive, agent, antidote, anti-venom, hormone, stimulant, vasodilator, anesthetic, or nutritional supplement.
10. The apparatus of claim 1, wherein the medicament is epinephrine.
11. An apparatus, comprising:
a housing having a contact member disposed at a distal end portion of the housing, a distal end surface of the housing defining an opening;
a medicament carrier movably disposed within the housing, the medicament carrier configured to be coupled to a medicament container and a needle such that the needle is in fluid communication with the medicament container;
a delivery mechanism configured to produce a force to move the medicament carrier within the housing such that a portion of the needle is disposed outside of the housing via the opening;
an actuator configured to be manipulated by a user to actuate the delivery mechanism; and an electronic circuit system including a light output device, the electronic circuit system configured to produce a visual output via the light output device to illuminate the actuator in response to a portion of the contact member contacting a body.
12. The apparatus of claim 11, wherein the electronic circuit system includes a sensor configured to produce a signal when the portion of the contact member is in contact with the body.
13. The apparatus of claim 11, further comprising:
the medicament container containing one of a medicine, medication, drug, pharmaceutical, prescriptive, agent, antidote, anti-venom, hormone, stimulant, vasodilator, anesthetic, or nutritional supplement.
14. The apparatus of claim 11, further comprising:
the medicament container containing epinephrine.
15. The apparatus of claim 11, further comprising:
the needle, a longitudinal axis of the needle being offset from a longitudinal axis of an energy storage member of the delivery mechanism.
16. The apparatus of claim 11, wherein:
the electronic circuit system includes a speaker, the electronic circuit system configured to produce a recorded speech output in response to the portion of the contact member contacting the body; and the visual output and the recorded speech output collectively identifying the actuator.
17. An apparatus, comprising:
a housing having a contact member disposed at a distal end portion of the housing, a distal end surface of the housing defining an opening;
a medicament carrier movably disposed within the housing, the medicament carrier configured to be coupled to a medicament container;
a delivery mechanism configured to produce a force to move the medicament carrier within the housing to convey a medicament from the medicament container via the opening; and an electronic circuit system including a light output device and an audible output device, the electronic circuit system configured to produce a visual output via the light output device and an audible output via the audible output device in response to a portion of the contact member contacting a body.
18. The apparatus of claim 17, further comprising:
an actuator configured to be manipulated by a user to actuate the delivery mechanism, the visual output configured to illuminate the actuator.
19. The apparatus of claim 17, wherein the audible output is a recorded speech output, the apparatus further comprising:
an actuator configured to be manipulated by a user to actuate the delivery mechanism, the visual output and the recorded speech output collectively identifying the actuator.
20. The apparatus of claim 17, further comprising:
the medicament container coupled to the medicament carrier, the medicament container containing epinephrine.
21. The apparatus of claim 17, further comprising:
the medicament container coupled to the medicament carrier, the medicament container containing one of a medicine, medication, drug, pharmaceutical, prescriptive, agent, antidote, anti-venom, hormone, stimulant, vasodilator, anesthetic, or nutritional supplement; and a needle coupled to the medicament carrier and in fluid communication with the medicament container, the delivery mechanism configured to move the needle between a first position and a second position, in the first position the needle is contained within the housing, in the second position a portion of the needle extends from the housing via the opening, the delivery mechanism including an energy storage member having a longitudinal axis offset from a longitudinal axis of the needle.
22. An apparatus, comprising:
a medicament delivery device configured to deliver a medicament, the medicament delivery device including:
a housing;
a medicament container disposed within the housing, the medicament container configured to contain the medicament;
an activation mechanism including an energy storage member, configured to produce a force to move the medicament container within the housing to deliver the medicament; an actuator configured to actuate the activation mechanism when the actuator is moved relative to the housing;
a safety lock configured to engage at least one of a portion of the activation mechanism or the actuator to prevent actuation of the activation mechanism;
and an electronic circuit system configured to be coupled to the housing, the electronic circuit system including a switch configured to be moved from a first state to a second state when the actuator is moved relative to the housing to actuate the activation mechanism, the electronic circuit system configured to output a first electronic output providing an instruction for actuating the activation mechanism and a second electronic output when the switch is changed to the second state.
23. The apparatus of claim 22, wherein at least one of the first electronic output or the second electronic output includes a signal associated with at least one of a visual output, an audible output, a thermal output or a haptic output.
24. The apparatus of claim 22, wherein at least one of the first electronic output or the second electronic output includes recorded speech.
25. The apparatus of claim 22, wherein at least one of the first electronic output or the second electronic output includes a visual indicia associated with a placement of the medicament delivery device against a body.
26. The apparatus of claim 22, wherein:
the switch is a first switch;
the safety lock is movably coupled to the housing, the safety lock configured to limit movement of the actuator; and the electronic circuit system includes a second switch operably coupled to the safety lock such that the safety lock changes the second switch from a first state to a second state when the safety lock is moved, the electronic circuit system i-s configured to output the first electronic output when the second switch is moved from its first state to its second state.
27. The apparatus of claim 22, wherein:
the electronic circuit system includes a sensor; and the electronic circuit system is configured to output at least one of the first electronic output or the second electronic output in response to an input received from the sensor.
28. The apparatus of claim 22, wherein:
the medicament delivery device further includes a label configured to be coupled to the housing; and at least a portion of the electronic circuit system is incorporated into the label.
29. The apparatus of claim 22, wherein the medicament delivery device further includes a needle configured to be in fluid communication with the medicament container, the needle configured to be moved between a first position and a second position, in the first position the needle is contained within the housing, in the second position a portion of the needle extends from the housing.
30. The apparatus of claim 22, wherein the energy storage member is any one of a spring or a compressed gas container.
31. The apparatus of claim 22, wherein:
The actuator is coupled to a distal end portion of the housing; and the electronic circuit system includes a light output device disposed at the distal end portion of the housing, the first electronic output including a light output produced via the light output device.
32. The apparatus of claim 22, wherein:
the activation mechanism includes a spring and a release member, the release member configured to be moved within the housing by the spring when the release member is released; and the safety lock includes a separation portion configured to engage a portion of the release member to prevent release of the release member.
33. An apparatus, comprising:
a medicament delivery device configured to deliver a medicament, the medicament delivery device including:
a housing;
a medicament container disposed within the housing, the medicament container configured to contain the medicament;
a delivery mechanism configured to produce a force to deliver the medicament;
an actuator configured to actuate the delivery mechanism when the actuator is moved relative to the housing;
a safety lock configured to engage at least one of a portion of the delivery mechanism or the actuator to prevent actuation of the delivery mechanism; and an electronic circuit system configured to be coupled to the housing, the electronic circuit system configured to output a plurality of recorded speech instructions, the electronic circuit system including a switch operably coupled to the safety lock such that the safety lock changes the switch from a first state to a second state when the safety lock is moved, the electronic circuit system configured to output a first recorded speech instruction from the plurality of recorded speech instructions when the switch is changed to the second state, the delivery mechanism configured to produce the force independently from the electronic circuit system.
34. The apparatus of claim 33, wherein the plurality of recorded speech instructions is output in a predetermined sequence.
35. The apparatus of claim 33, wherein the plurality of recorded speech instructions is output in a sequence determined based on input received from any one of a switch, a sensor or a timer.
36. The apparatus of claim 33, wherein the plurality of recorded speech instructions is a first plurality of recorded speech instructions; and the electronic circuit system is further configured to output a second plurality of recorded speech instructions associated with an event subsequent to the use of the medicament delivery device.
36. The apparatus of claim 33, wherein the delivery mechanism includes any one of a spring or a gas container configured to produce the force.
37. The apparatus of claim 33, wherein:
the electronic circuit system is configured to output a second recorded speech instruction from the plurality of recorded speech instructions in response to the actuator being moved relative to the housing.
38. The apparatus of claim 33, wherein:
the switch is a first switch; and the electronic circuit system includes a second switch operably coupled to the actuator such that the actuator changes the second switch from a first state to a second state when the actuator moves relative to the housing, the electronic circuit system configured to output a second recorded speech instruction from the plurality of recorded speech instructions when the second switch is changed to the second state.
39. The apparatus of claim 33, wherein the delivery mechanism includes a non-electronic energy storage member configured to produce the force when actuated.
40. The apparatus of claim 33, wherein:
the electronic circuit system includes a light output device adjacent the actuator, the electronic circuit system configured to produce a light output via the light output device when the switch is actuated; and the first recorded speech instruction identifies a location of the actuator.
42. The apparatus of any preceding claim, wherein the medicament is one of a medicine, medication, drug, pharmaceutical, prescriptive, agent, antidote, anti-venom, hormone, stimulant, vasodilator, anesthetic, or nutritional supplement.
43. The apparatus of any preceding claim, wherein the medicament is epinephrine.
1. An apparatus, comprising:
a housing, a distal end surface of the housing defining an opening;
a medicament container disposed within the housing;
a delivery mechanism configured to produce a force to convey a medicament from the medicament container via the opening; and an electronic circuit system including a light output device and a sensor, the sensor configured to produce a signal when the distal end surface is in contact with a body, the electronic circuit system configured to produce a visual output via the light output device in response to the signal produced by the sensor.
2. The apparatus of claim 1, further comprising:
an actuator configured to be manipulated by a user to actuate the delivery mechanism, the visual output configured to illuminate the actuator.
3. The apparatus of claim 1, wherein the sensor is a proximity sensor disposed at the distal end surface of the housing.
4. The apparatus of claim 1, wherein the electronic circuit system includes a speaker, the electronic circuit system configured to produce an audible output in response to the signal produced by the sensor.
5. The apparatus of claim 1, wherein the electronic circuit system includes a speaker, the electronic circuit system configured to produce a recorded speech output in response to the signal produced by the sensor, the apparatus further comprising:
an actuator configured to be manipulated by a user to actuate the delivery mechanism, the visual output and the recorded speech output collectively identifying the actuator.
6. The apparatus of claim 1, further comprising:
a locking member movably coupled to the housing, the locking member configured to engage a portion of the delivery mechanism to limit movement of the delivery mechanism, the electronic circuit system including a switch operably coupled to the locking member such that the locking member actuates the switch when the locking member is moved, the electronic circuit system configured to produce an electronic output when the locking member actuates the switch.
7. The apparatus of claim 1, further comprising:
a needle configured to be in fluid communication with the medicament container, the delivery mechanism configured to move the needle between a first position and a second position, in the first position the needle is contained within the housing, in the second position a portion of the needle extends from the housing via the opening, the delivery mechanism including an energy storage member having a longitudinal axis offset from a longitudinal axis of the needle.
8. The apparatus of claim 1, wherein the light output device is any one of a light-emitting diode, a liquid crystal display, an organic polymer display or a fiber optic display.
9. The apparatus of claim 1, wherein the medicament is any one of a medicine, medication, drug, pharmaceutical, prescriptive, agent, antidote, anti-venom, hormone, stimulant, vasodilator, anesthetic, or nutritional supplement.
10. The apparatus of claim 1, wherein the medicament is epinephrine.
11. An apparatus, comprising:
a housing having a contact member disposed at a distal end portion of the housing, a distal end surface of the housing defining an opening;
a medicament carrier movably disposed within the housing, the medicament carrier configured to be coupled to a medicament container and a needle such that the needle is in fluid communication with the medicament container;
a delivery mechanism configured to produce a force to move the medicament carrier within the housing such that a portion of the needle is disposed outside of the housing via the opening;
an actuator configured to be manipulated by a user to actuate the delivery mechanism; and an electronic circuit system including a light output device, the electronic circuit system configured to produce a visual output via the light output device to illuminate the actuator in response to a portion of the contact member contacting a body.
12. The apparatus of claim 11, wherein the electronic circuit system includes a sensor configured to produce a signal when the portion of the contact member is in contact with the body.
13. The apparatus of claim 11, further comprising:
the medicament container containing one of a medicine, medication, drug, pharmaceutical, prescriptive, agent, antidote, anti-venom, hormone, stimulant, vasodilator, anesthetic, or nutritional supplement.
14. The apparatus of claim 11, further comprising:
the medicament container containing epinephrine.
15. The apparatus of claim 11, further comprising:
the needle, a longitudinal axis of the needle being offset from a longitudinal axis of an energy storage member of the delivery mechanism.
16. The apparatus of claim 11, wherein:
the electronic circuit system includes a speaker, the electronic circuit system configured to produce a recorded speech output in response to the portion of the contact member contacting the body; and the visual output and the recorded speech output collectively identifying the actuator.
17. An apparatus, comprising:
a housing having a contact member disposed at a distal end portion of the housing, a distal end surface of the housing defining an opening;
a medicament carrier movably disposed within the housing, the medicament carrier configured to be coupled to a medicament container;
a delivery mechanism configured to produce a force to move the medicament carrier within the housing to convey a medicament from the medicament container via the opening; and an electronic circuit system including a light output device and an audible output device, the electronic circuit system configured to produce a visual output via the light output device and an audible output via the audible output device in response to a portion of the contact member contacting a body.
18. The apparatus of claim 17, further comprising:
an actuator configured to be manipulated by a user to actuate the delivery mechanism, the visual output configured to illuminate the actuator.
19. The apparatus of claim 17, wherein the audible output is a recorded speech output, the apparatus further comprising:
an actuator configured to be manipulated by a user to actuate the delivery mechanism, the visual output and the recorded speech output collectively identifying the actuator.
20. The apparatus of claim 17, further comprising:
the medicament container coupled to the medicament carrier, the medicament container containing epinephrine.
21. The apparatus of claim 17, further comprising:
the medicament container coupled to the medicament carrier, the medicament container containing one of a medicine, medication, drug, pharmaceutical, prescriptive, agent, antidote, anti-venom, hormone, stimulant, vasodilator, anesthetic, or nutritional supplement; and a needle coupled to the medicament carrier and in fluid communication with the medicament container, the delivery mechanism configured to move the needle between a first position and a second position, in the first position the needle is contained within the housing, in the second position a portion of the needle extends from the housing via the opening, the delivery mechanism including an energy storage member having a longitudinal axis offset from a longitudinal axis of the needle.
22. An apparatus, comprising:
a medicament delivery device configured to deliver a medicament, the medicament delivery device including:
a housing;
a medicament container disposed within the housing, the medicament container configured to contain the medicament;
an activation mechanism including an energy storage member, configured to produce a force to move the medicament container within the housing to deliver the medicament; an actuator configured to actuate the activation mechanism when the actuator is moved relative to the housing;
a safety lock configured to engage at least one of a portion of the activation mechanism or the actuator to prevent actuation of the activation mechanism;
and an electronic circuit system configured to be coupled to the housing, the electronic circuit system including a switch configured to be moved from a first state to a second state when the actuator is moved relative to the housing to actuate the activation mechanism, the electronic circuit system configured to output a first electronic output providing an instruction for actuating the activation mechanism and a second electronic output when the switch is changed to the second state.
23. The apparatus of claim 22, wherein at least one of the first electronic output or the second electronic output includes a signal associated with at least one of a visual output, an audible output, a thermal output or a haptic output.
24. The apparatus of claim 22, wherein at least one of the first electronic output or the second electronic output includes recorded speech.
25. The apparatus of claim 22, wherein at least one of the first electronic output or the second electronic output includes a visual indicia associated with a placement of the medicament delivery device against a body.
26. The apparatus of claim 22, wherein:
the switch is a first switch;
the safety lock is movably coupled to the housing, the safety lock configured to limit movement of the actuator; and the electronic circuit system includes a second switch operably coupled to the safety lock such that the safety lock changes the second switch from a first state to a second state when the safety lock is moved, the electronic circuit system i-s configured to output the first electronic output when the second switch is moved from its first state to its second state.
27. The apparatus of claim 22, wherein:
the electronic circuit system includes a sensor; and the electronic circuit system is configured to output at least one of the first electronic output or the second electronic output in response to an input received from the sensor.
28. The apparatus of claim 22, wherein:
the medicament delivery device further includes a label configured to be coupled to the housing; and at least a portion of the electronic circuit system is incorporated into the label.
29. The apparatus of claim 22, wherein the medicament delivery device further includes a needle configured to be in fluid communication with the medicament container, the needle configured to be moved between a first position and a second position, in the first position the needle is contained within the housing, in the second position a portion of the needle extends from the housing.
30. The apparatus of claim 22, wherein the energy storage member is any one of a spring or a compressed gas container.
31. The apparatus of claim 22, wherein:
The actuator is coupled to a distal end portion of the housing; and the electronic circuit system includes a light output device disposed at the distal end portion of the housing, the first electronic output including a light output produced via the light output device.
32. The apparatus of claim 22, wherein:
the activation mechanism includes a spring and a release member, the release member configured to be moved within the housing by the spring when the release member is released; and the safety lock includes a separation portion configured to engage a portion of the release member to prevent release of the release member.
33. An apparatus, comprising:
a medicament delivery device configured to deliver a medicament, the medicament delivery device including:
a housing;
a medicament container disposed within the housing, the medicament container configured to contain the medicament;
a delivery mechanism configured to produce a force to deliver the medicament;
an actuator configured to actuate the delivery mechanism when the actuator is moved relative to the housing;
a safety lock configured to engage at least one of a portion of the delivery mechanism or the actuator to prevent actuation of the delivery mechanism; and an electronic circuit system configured to be coupled to the housing, the electronic circuit system configured to output a plurality of recorded speech instructions, the electronic circuit system including a switch operably coupled to the safety lock such that the safety lock changes the switch from a first state to a second state when the safety lock is moved, the electronic circuit system configured to output a first recorded speech instruction from the plurality of recorded speech instructions when the switch is changed to the second state, the delivery mechanism configured to produce the force independently from the electronic circuit system.
34. The apparatus of claim 33, wherein the plurality of recorded speech instructions is output in a predetermined sequence.
35. The apparatus of claim 33, wherein the plurality of recorded speech instructions is output in a sequence determined based on input received from any one of a switch, a sensor or a timer.
36. The apparatus of claim 33, wherein the plurality of recorded speech instructions is a first plurality of recorded speech instructions; and the electronic circuit system is further configured to output a second plurality of recorded speech instructions associated with an event subsequent to the use of the medicament delivery device.
36. The apparatus of claim 33, wherein the delivery mechanism includes any one of a spring or a gas container configured to produce the force.
37. The apparatus of claim 33, wherein:
the electronic circuit system is configured to output a second recorded speech instruction from the plurality of recorded speech instructions in response to the actuator being moved relative to the housing.
38. The apparatus of claim 33, wherein:
the switch is a first switch; and the electronic circuit system includes a second switch operably coupled to the actuator such that the actuator changes the second switch from a first state to a second state when the actuator moves relative to the housing, the electronic circuit system configured to output a second recorded speech instruction from the plurality of recorded speech instructions when the second switch is changed to the second state.
39. The apparatus of claim 33, wherein the delivery mechanism includes a non-electronic energy storage member configured to produce the force when actuated.
40. The apparatus of claim 33, wherein:
the electronic circuit system includes a light output device adjacent the actuator, the electronic circuit system configured to produce a light output via the light output device when the switch is actuated; and the first recorded speech instruction identifies a location of the actuator.
42. The apparatus of any preceding claim, wherein the medicament is one of a medicine, medication, drug, pharmaceutical, prescriptive, agent, antidote, anti-venom, hormone, stimulant, vasodilator, anesthetic, or nutritional supplement.
43. The apparatus of any preceding claim, wherein the medicament is epinephrine.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2976873A CA2976873C (en) | 2005-02-01 | 2006-02-01 | Devices, systems, and methods for medicament delivery |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64882205P | 2005-02-01 | 2005-02-01 | |
US60/648,822 | 2005-02-01 | ||
US73188605P | 2005-10-31 | 2005-10-31 | |
US60/731,886 | 2005-10-31 | ||
CA 2594627 CA2594627C (en) | 2005-02-01 | 2006-02-01 | Devices, systems, and methods for medicament delivery |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA 2594627 Division CA2594627C (en) | 2005-02-01 | 2006-02-01 | Devices, systems, and methods for medicament delivery |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2976873A Division CA2976873C (en) | 2005-02-01 | 2006-02-01 | Devices, systems, and methods for medicament delivery |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2762072A1 true CA2762072A1 (en) | 2006-08-10 |
CA2762072C CA2762072C (en) | 2017-08-29 |
Family
ID=36777846
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA 2594627 Active CA2594627C (en) | 2005-02-01 | 2006-02-01 | Devices, systems, and methods for medicament delivery |
CA2762072A Active CA2762072C (en) | 2005-02-01 | 2006-02-01 | Devices, systems, and methods for medicament delivery |
CA2976873A Expired - Fee Related CA2976873C (en) | 2005-02-01 | 2006-02-01 | Devices, systems, and methods for medicament delivery |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA 2594627 Active CA2594627C (en) | 2005-02-01 | 2006-02-01 | Devices, systems, and methods for medicament delivery |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2976873A Expired - Fee Related CA2976873C (en) | 2005-02-01 | 2006-02-01 | Devices, systems, and methods for medicament delivery |
Country Status (15)
Country | Link |
---|---|
US (12) | US7749194B2 (en) |
EP (2) | EP1843812A4 (en) |
JP (1) | JP4948422B2 (en) |
CN (1) | CN101111281B (en) |
AU (2) | AU2006210865B2 (en) |
CA (3) | CA2594627C (en) |
DK (1) | DK2058020T3 (en) |
ES (1) | ES2396745T3 (en) |
GB (2) | GB2440039A (en) |
HK (1) | HK1126992A1 (en) |
IL (1) | IL184552A (en) |
MX (1) | MX2007009152A (en) |
NZ (1) | NZ560516A (en) |
PL (1) | PL2058020T3 (en) |
WO (1) | WO2006083876A2 (en) |
Families Citing this family (307)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6231565B1 (en) | 1997-06-18 | 2001-05-15 | United States Surgical Corporation | Robotic arm DLUs for performing surgical tasks |
DE60323729D1 (en) | 2002-02-11 | 2008-11-06 | Antares Pharma Inc | INTRADERMAL INJECTION DEVICE |
US7338443B1 (en) | 2002-04-29 | 2008-03-04 | Tucker Peter L | Secure patient data recorder for recording monitored vital sign data |
US7553296B2 (en) * | 2003-02-14 | 2009-06-30 | Tyco Healthcare Group Lp | Safety device with trigger mechanism |
ES2737835T3 (en) | 2003-04-23 | 2020-01-16 | Valeritas Inc | Hydraulically driven pump for long-term medication administration |
GB0414054D0 (en) | 2004-06-23 | 2004-07-28 | Owen Mumford Ltd | Improvements relating to automatic injection devices |
US9089636B2 (en) | 2004-07-02 | 2015-07-28 | Valeritas, Inc. | Methods and devices for delivering GLP-1 and uses thereof |
US8048035B2 (en) | 2004-08-06 | 2011-11-01 | Meridian Medical Technologies, Inc. | Automatic injector with needle cover |
US8252321B2 (en) | 2004-09-13 | 2012-08-28 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like |
AU2005284908B2 (en) | 2004-09-13 | 2011-12-08 | Morningside Venture Investments Limited | Biosynchronous transdermal drug delivery |
US11590286B2 (en) | 2004-11-22 | 2023-02-28 | Kaleo, Inc. | Devices, systems and methods for medicament delivery |
US7648482B2 (en) | 2004-11-22 | 2010-01-19 | Intelliject, Inc. | Devices, systems, and methods for medicament delivery |
US7648483B2 (en) | 2004-11-22 | 2010-01-19 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
CA2891057C (en) | 2004-11-22 | 2018-11-13 | Kaleo, Inc. | Medicament delivery apparatus and movable indicator |
US10737028B2 (en) | 2004-11-22 | 2020-08-11 | Kaleo, Inc. | Devices, systems and methods for medicament delivery |
US7947017B2 (en) | 2004-11-22 | 2011-05-24 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
JP5216328B2 (en) | 2005-01-24 | 2013-06-19 | アンタレス ファーマ インコーポレイテッド | Pre-filled needle assist syringe jet injector |
US8361026B2 (en) * | 2005-02-01 | 2013-01-29 | Intelliject, Inc. | Apparatus and methods for self-administration of vaccines and other medicaments |
JP4948422B2 (en) | 2005-02-01 | 2012-06-06 | インテリジェクト,インコーポレイテッド | Drug delivery apparatus, system and method |
US7731686B2 (en) * | 2005-02-01 | 2010-06-08 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
US8206360B2 (en) | 2005-02-01 | 2012-06-26 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
US9022980B2 (en) | 2005-02-01 | 2015-05-05 | Kaleo, Inc. | Medical injector simulation device |
US8231573B2 (en) | 2005-02-01 | 2012-07-31 | Intelliject, Inc. | Medicament delivery device having an electronic circuit system |
WO2006127905A2 (en) | 2005-05-24 | 2006-11-30 | Chrono Therapeutics, Inc. | Portable drug delivery device |
US8518069B2 (en) | 2005-09-07 | 2013-08-27 | Cabochon Aesthetics, Inc. | Dissection handpiece and method for reducing the appearance of cellulite |
US7967763B2 (en) | 2005-09-07 | 2011-06-28 | Cabochon Aesthetics, Inc. | Method for treating subcutaneous tissues |
US10548659B2 (en) | 2006-01-17 | 2020-02-04 | Ulthera, Inc. | High pressure pre-burst for improved fluid delivery |
US9358033B2 (en) | 2005-09-07 | 2016-06-07 | Ulthera, Inc. | Fluid-jet dissection system and method for reducing the appearance of cellulite |
US9011473B2 (en) | 2005-09-07 | 2015-04-21 | Ulthera, Inc. | Dissection handpiece and method for reducing the appearance of cellulite |
US9486274B2 (en) | 2005-09-07 | 2016-11-08 | Ulthera, Inc. | Dissection handpiece and method for reducing the appearance of cellulite |
US20080200864A1 (en) * | 2005-12-02 | 2008-08-21 | Cabochon Aesthetics, Inc. | Devices and methods for selectively lysing cells |
US9248317B2 (en) * | 2005-12-02 | 2016-02-02 | Ulthera, Inc. | Devices and methods for selectively lysing cells |
US20080014627A1 (en) * | 2005-12-02 | 2008-01-17 | Cabochon Aesthetics, Inc. | Devices and methods for selectively lysing cells |
US20080195036A1 (en) * | 2005-12-02 | 2008-08-14 | Cabochon Aesthetics, Inc. | Devices and methods for selectively lysing cells |
US7885793B2 (en) | 2007-05-22 | 2011-02-08 | International Business Machines Corporation | Method and system for developing a conceptual model to facilitate generating a business-aligned information technology solution |
US20080200863A1 (en) * | 2005-12-02 | 2008-08-21 | Cabochon Aesthetics, Inc. | Devices and methods for selectively lysing cells |
US20080197517A1 (en) * | 2005-12-02 | 2008-08-21 | Cabochon Aesthetics, Inc. | Devices and methods for selectively lysing cells |
WO2007092637A2 (en) | 2006-02-09 | 2007-08-16 | Deka Products Limited Partnership | Patch-sized fluid delivery systems and methods |
AU2011218649B8 (en) * | 2006-03-29 | 2015-11-19 | Kaleo, Inc. | Devices, systems and methods for medicament delivery |
SG173319A1 (en) | 2006-03-30 | 2011-08-29 | Valeritas Inc | Multi-cartridge fluid delivery device |
US8251947B2 (en) | 2006-05-03 | 2012-08-28 | Antares Pharma, Inc. | Two-stage reconstituting injector |
WO2007131025A1 (en) | 2006-05-03 | 2007-11-15 | Antares Pharma, Inc. | Injector with adjustable dosing |
CN101437559B (en) | 2006-05-04 | 2011-12-14 | 皇家飞利浦电子股份有限公司 | Medical injector |
US20080003555A1 (en) * | 2006-06-29 | 2008-01-03 | Johan Ekvall | System and method for facilitating setup of surgical instrumentation and consumables associated therewith |
NZ572765A (en) | 2006-06-30 | 2012-08-31 | Abbott Biotech Ltd | Automatic injection device with rod driving syringe longitudinally split with radially compressible pair of wings along its length |
JP5241714B2 (en) | 2006-07-07 | 2013-07-17 | プロテウス デジタル ヘルス, インコーポレイテッド | Smart parenteral delivery system |
DE202006018609U1 (en) * | 2006-08-29 | 2007-05-16 | Euro-Celtique S.A. | Needle-free apparatus for administrating pharmaceutical composition in humans, comprises a housing; auxiliary substance to force a pharmaceutical composition from a package into human body; a composition comprising analgesic, e.g. opioids |
US20080110453A1 (en) * | 2006-11-15 | 2008-05-15 | Delphi Technologies Inc. | Nebulizer and methods for controlling the nebulizer |
WO2008064092A2 (en) | 2006-11-21 | 2008-05-29 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
US8352041B2 (en) * | 2006-11-28 | 2013-01-08 | The Alfred E. Mann Foundation For Scientific Research | Remote controls and ambulatory medical systems including the same |
WO2008091838A2 (en) | 2007-01-22 | 2008-07-31 | Intelliject, Inc. | Medical injector with compliance tracking and monitoring |
US20080195416A1 (en) * | 2007-02-08 | 2008-08-14 | Forhealth Technologies, Inc. | Automated centralized preparation of medications in anticipation of use |
CN104069567A (en) * | 2007-03-19 | 2014-10-01 | 茵苏莱恩医药有限公司 | Drug delivery device |
US8622991B2 (en) | 2007-03-19 | 2014-01-07 | Insuline Medical Ltd. | Method and device for drug delivery |
WO2008114224A2 (en) * | 2007-03-19 | 2008-09-25 | Insuline Medical Ltd. | Method and device for substance measurement |
US9220837B2 (en) | 2007-03-19 | 2015-12-29 | Insuline Medical Ltd. | Method and device for drug delivery |
US20080287873A1 (en) * | 2007-04-13 | 2008-11-20 | Aldo Liberatore | Method and apparatus for controlling operation of a syringe |
US20080299906A1 (en) * | 2007-06-04 | 2008-12-04 | Topway Electrical Appliance Company | Emulating playing apparatus of simulating games |
US8614985B2 (en) * | 2007-06-15 | 2013-12-24 | Futurewei Technologies, Inc. | Method and apparatus for sharing a group resource in a wireless SDMA system |
US8130780B2 (en) | 2007-06-15 | 2012-03-06 | Futurewei Technologies, Inc. | Method and apparatus for assigning resources in a wireless system with multiple regions |
US20080310359A1 (en) * | 2007-06-15 | 2008-12-18 | Mcbeath Sean Michael | Method and Apparatus for Sharing Resources in a Wireless System |
US9544911B2 (en) * | 2007-08-10 | 2017-01-10 | Futurewei Technologies, Inc. | System and method for assigning communications resources in a wireless communications system |
US20110097318A1 (en) * | 2007-08-31 | 2011-04-28 | Amgen Inc. | Solid-State Protein Formulation |
IL185741A0 (en) * | 2007-09-05 | 2008-01-06 | Sindolor Medical Ltd | Envelope containing sterile needle |
US9656019B2 (en) | 2007-10-02 | 2017-05-23 | Medimop Medical Projects Ltd. | Apparatuses for securing components of a drug delivery system during transport and methods of using same |
US7967795B1 (en) | 2010-01-19 | 2011-06-28 | Lamodel Ltd. | Cartridge interface assembly with driving plunger |
US10420880B2 (en) | 2007-10-02 | 2019-09-24 | West Pharma. Services IL, Ltd. | Key for securing components of a drug delivery system during assembly and/or transport and methods of using same |
WO2009044401A2 (en) | 2007-10-02 | 2009-04-09 | Yossi Gross | External drug pump |
US9345836B2 (en) | 2007-10-02 | 2016-05-24 | Medimop Medical Projects Ltd. | Disengagement resistant telescoping assembly and unidirectional method of assembly for such |
US8439940B2 (en) | 2010-12-22 | 2013-05-14 | Cabochon Aesthetics, Inc. | Dissection handpiece with aspiration means for reducing the appearance of cellulite |
EP2211974A4 (en) | 2007-10-25 | 2013-02-27 | Proteus Digital Health Inc | Fluid transfer port information system |
US8419638B2 (en) | 2007-11-19 | 2013-04-16 | Proteus Digital Health, Inc. | Body-associated fluid transport structure evaluation devices |
EP2231229A1 (en) * | 2007-12-18 | 2010-09-29 | Insuline Medical Ltd. | Drug delivery device with sensor for closed-loop operation |
US9044542B2 (en) | 2007-12-21 | 2015-06-02 | Carticept Medical, Inc. | Imaging-guided anesthesia injection systems and methods |
WO2009086182A1 (en) | 2007-12-21 | 2009-07-09 | Carticept Medical, Inc. | Articular injection system |
US8545440B2 (en) | 2007-12-21 | 2013-10-01 | Carticept Medical, Inc. | Injection system for delivering multiple fluids within the anatomy |
US8313467B2 (en) | 2007-12-27 | 2012-11-20 | Medtronic Minimed, Inc. | Reservoir pressure equalization systems and methods |
WO2009114542A1 (en) | 2008-03-10 | 2009-09-17 | Antares Pharma, Inc. | Injector safety device |
US8177758B2 (en) * | 2008-04-08 | 2012-05-15 | Rochester Area Consulting Engineers (RACE) | Pneumatic injector |
US8021344B2 (en) | 2008-07-28 | 2011-09-20 | Intelliject, Inc. | Medicament delivery device configured to produce an audible output |
JP5653345B2 (en) * | 2008-05-12 | 2015-01-14 | カレオ,インコーポレイテッド | Drug delivery device with electronic circuit system |
USD994111S1 (en) | 2008-05-12 | 2023-08-01 | Kaleo, Inc. | Medicament delivery device cover |
CA2724641C (en) | 2008-05-20 | 2020-03-24 | Avant Medical Corp. | Autoinjector system |
US8177749B2 (en) | 2008-05-20 | 2012-05-15 | Avant Medical Corp. | Cassette for a hidden injection needle |
US8052645B2 (en) | 2008-07-23 | 2011-11-08 | Avant Medical Corp. | System and method for an injection using a syringe needle |
AU2009279719B2 (en) | 2008-08-05 | 2015-07-23 | Antares Pharma, Inc. | Multiple dosage injector |
AU2009286377A1 (en) * | 2008-08-25 | 2010-03-04 | Koninklijke Philips Electronics N.V. | Respiratory drug delivery apparatus which provides audio instructions |
US9393369B2 (en) | 2008-09-15 | 2016-07-19 | Medimop Medical Projects Ltd. | Stabilized pen injector |
EP2355758A2 (en) | 2008-11-07 | 2011-08-17 | Insuline Medical Ltd. | Device and method for drug delivery |
GB0821492D0 (en) * | 2008-11-25 | 2008-12-31 | Team Holdings Uk Ltd | Integrated auto-injector cartridge system |
DE102008062319B4 (en) * | 2008-12-16 | 2012-05-31 | Dräger Medical GmbH | Hose nozzle for a ventilator |
US8152779B2 (en) | 2008-12-30 | 2012-04-10 | Medimop Medical Projects Ltd. | Needle assembly for drug pump |
DE202009001836U1 (en) * | 2009-02-13 | 2009-05-20 | Dieter Hölzle Technik-Projekte GmbH | Electromechanical injection device |
CN102413856B (en) | 2009-02-27 | 2017-02-08 | 生命扫描有限公司 | Drug delivery system |
AU2010226442A1 (en) | 2009-03-20 | 2011-10-13 | Antares Pharma, Inc. | Hazardous agent injection system |
AU2010266033B2 (en) * | 2009-06-24 | 2014-07-10 | Carticept Medical, Inc. | Injection system for delivering multiple fluids within the anatomy |
US8393357B2 (en) | 2009-07-08 | 2013-03-12 | Medtronic Minimed, Inc. | Reservoir filling systems and methods |
US8167846B2 (en) | 2009-07-08 | 2012-05-01 | Medtronic Minimed, Inc. | Reservoir filling systems and methods |
DE102009033967A1 (en) * | 2009-07-21 | 2011-01-27 | Robert Bosch Gmbh | Method for programming a programmable logic controller with resistant data storage |
CA2921304C (en) | 2009-07-30 | 2018-06-05 | Tandem Diabetes Care, Inc. | Infusion pump system with disposable cartridge having pressure venting and pressure feedback |
US9358064B2 (en) | 2009-08-07 | 2016-06-07 | Ulthera, Inc. | Handpiece and methods for performing subcutaneous surgery |
US11096708B2 (en) | 2009-08-07 | 2021-08-24 | Ulthera, Inc. | Devices and methods for performing subcutaneous surgery |
US10071198B2 (en) | 2012-11-02 | 2018-09-11 | West Pharma. Servicees IL, Ltd. | Adhesive structure for medical device |
USD810278S1 (en) | 2009-09-15 | 2018-02-13 | Medimop Medical Projects Ltd. | Injector device |
US10071196B2 (en) | 2012-05-15 | 2018-09-11 | West Pharma. Services IL, Ltd. | Method for selectively powering a battery-operated drug-delivery device and device therefor |
US8157769B2 (en) | 2009-09-15 | 2012-04-17 | Medimop Medical Projects Ltd. | Cartridge insertion assembly for drug delivery system |
JP5814244B2 (en) * | 2009-09-30 | 2015-11-17 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Drug delivery device |
EP2485786B1 (en) | 2009-10-08 | 2020-08-19 | SHL Medical AG | Medicament delivery device |
MX2012004446A (en) | 2009-10-16 | 2012-06-08 | Janssen Biotech Inc | Palm activated drug delivery device. |
US9233213B2 (en) | 2009-10-16 | 2016-01-12 | Janssen Biotech, Inc. | Palm activated drug delivery device |
US10350364B2 (en) | 2009-11-11 | 2019-07-16 | Windgap Medical, Inc. | Portable Drug Mixing and Delivery Device and Associated Methods |
US8928467B2 (en) | 2009-11-25 | 2015-01-06 | Tjt Holdings, Llc | Programmable audio device |
EP2335755A1 (en) | 2009-12-17 | 2011-06-22 | Sanofi-Aventis Deutschland GmbH | Device and method for delivery of two or more drug agents |
US20110140844A1 (en) * | 2009-12-15 | 2011-06-16 | Mcguire Kenneth Stephen | Packaged product having a reactive label and a method of its use |
WO2011079300A2 (en) * | 2009-12-23 | 2011-06-30 | Comau, Inc. | Universal human machine interface for automation installation |
US8348898B2 (en) | 2010-01-19 | 2013-01-08 | Medimop Medical Projects Ltd. | Automatic needle for drug pump |
KR20120114368A (en) | 2010-02-01 | 2012-10-16 | 프로테우스 디지털 헬스, 인코포레이티드 | Two-wrist data gathering system |
US8340461B2 (en) * | 2010-02-01 | 2012-12-25 | Microsoft Corporation | Single image haze removal using dark channel priors |
SG182825A1 (en) | 2010-02-01 | 2012-09-27 | Proteus Biomedical Inc | Data gathering system |
US8366667B2 (en) * | 2010-02-11 | 2013-02-05 | Baxter International Inc. | Flow pulsatility dampening devices |
EP2547384A4 (en) * | 2010-03-19 | 2014-07-23 | Halozyme Inc | Gas-pressured medication delivery device |
EP2389969A1 (en) * | 2010-05-26 | 2011-11-30 | Omrix Biopharmaceuticals Ltd. | A device for injecting a substance |
US9320647B2 (en) | 2010-03-31 | 2016-04-26 | Ocuject, Llc | Device and method for intraocular drug delivery |
US9408746B2 (en) | 2010-03-31 | 2016-08-09 | Ocuject, Llc | Device and method for intraocular drug delivery |
US9022988B1 (en) * | 2010-05-07 | 2015-05-05 | Kavan J. Shaban | System and method for controlling a self-injector device |
US9452261B2 (en) | 2010-05-10 | 2016-09-27 | Medimop Medical Projects Ltd. | Low volume accurate injector |
US8696640B2 (en) * | 2011-01-10 | 2014-04-15 | Russell Churchill | Snake venom evacuation and medication injection device |
EP2667918B1 (en) | 2011-01-24 | 2017-03-01 | AbbVie Biotechnology Ltd | Automatic injection devices having overmolded gripping surfaces |
US8939943B2 (en) | 2011-01-26 | 2015-01-27 | Kaleo, Inc. | Medicament delivery device for administration of opioid antagonists including formulations for naloxone |
US9084849B2 (en) | 2011-01-26 | 2015-07-21 | Kaleo, Inc. | Medicament delivery devices for administration of a medicament within a prefilled syringe |
US8627816B2 (en) | 2011-02-28 | 2014-01-14 | Intelliject, Inc. | Medicament delivery device for administration of opioid antagonists including formulations for naloxone |
DK2673020T3 (en) * | 2011-02-09 | 2017-11-20 | Sanofi Aventis Deutschland | PEN INJECTION DEVICE FOR TWO PHARMACEUTICALS WITH MICROR RESERVES CONTAINING SECONDARY EMERGENCY MEDICINE |
USD702834S1 (en) | 2011-03-22 | 2014-04-15 | Medimop Medical Projects Ltd. | Cartridge for use in injection device |
CA2773271C (en) | 2011-04-05 | 2016-10-11 | Tyco Healthcare Group Lp | Anesthetic syringe |
CA2833748C (en) | 2011-04-20 | 2019-07-16 | Amgen Inc. | Autoinjector apparatus |
CN103648560A (en) * | 2011-05-13 | 2014-03-19 | 赛诺菲-安万特德国有限公司 | Drug delivery device comprising safety lock member |
WO2013006643A1 (en) | 2011-07-06 | 2013-01-10 | The Parkinson's Institute | Compositions and methods for treatment of symptoms in parkinson's disease patients |
US8496619B2 (en) | 2011-07-15 | 2013-07-30 | Antares Pharma, Inc. | Injection device with cammed ram assembly |
US9220660B2 (en) | 2011-07-15 | 2015-12-29 | Antares Pharma, Inc. | Liquid-transfer adapter beveled spike |
CN111658892B (en) | 2011-12-21 | 2023-03-10 | 德卡产品有限公司 | Device for controlling fluid flow |
CN104245014B (en) | 2012-01-31 | 2017-05-24 | 麦迪麦珀医疗项目有限公司 | Time dependent drug delivery apparatus |
MX347426B (en) | 2012-03-02 | 2017-04-26 | Abbvie Inc | Automatic injection training device. |
DK2822618T3 (en) | 2012-03-06 | 2024-01-22 | Antares Pharma Inc | Pre-filled needle with breaking force function |
US10668213B2 (en) | 2012-03-26 | 2020-06-02 | West Pharma. Services IL, Ltd. | Motion activated mechanisms for a drug delivery device |
US9463280B2 (en) | 2012-03-26 | 2016-10-11 | Medimop Medical Projects Ltd. | Motion activated septum puncturing drug delivery device |
US9072827B2 (en) | 2012-03-26 | 2015-07-07 | Medimop Medical Projects Ltd. | Fail safe point protector for needle safety flap |
US9504603B2 (en) | 2012-04-02 | 2016-11-29 | Ocuject, Llc | Intraocular delivery devices and methods therefor |
US9421129B2 (en) | 2012-04-02 | 2016-08-23 | Ocuject, Llc | Intraocular delivery devices and methods therefor |
US9767708B2 (en) | 2012-04-04 | 2017-09-19 | Genia Medical Inc. | Medicament training device and system |
US10283014B2 (en) * | 2012-04-04 | 2019-05-07 | Jbcb Holdings, Llc | Smart packaging and display system |
EP2833944A4 (en) | 2012-04-06 | 2016-05-25 | Antares Pharma Inc | Needle assisted jet injection administration of testosterone compositions |
USD898908S1 (en) | 2012-04-20 | 2020-10-13 | Amgen Inc. | Pharmaceutical product cassette for an injection device |
WO2013169800A1 (en) * | 2012-05-07 | 2013-11-14 | Antares Pharma, Inc. | Injection device with cammed ram assembly |
US9180242B2 (en) | 2012-05-17 | 2015-11-10 | Tandem Diabetes Care, Inc. | Methods and devices for multiple fluid transfer |
US9522235B2 (en) | 2012-05-22 | 2016-12-20 | Kaleo, Inc. | Devices and methods for delivering medicaments from a multi-chamber container |
US9724191B2 (en) | 2012-06-04 | 2017-08-08 | Alcon Pharmaceuticals, Ltd. | Intraocular lens inserter |
DK2885031T3 (en) | 2012-08-20 | 2018-01-08 | Sanofi Aventis Deutschland | PHARMACEUTICAL DISPENSER DEVICE AND PROCEDURE FOR ELECTRIC DETECTION OF CONTACT BETWEEN Piston Rod and Cartridge Plug |
WO2014031150A1 (en) * | 2012-08-24 | 2014-02-27 | St. Jude Medical Puerto Rico Llc | Sealant storage, preparation, and delivery systems and related methods |
CN104602736B (en) * | 2012-09-05 | 2018-04-20 | E3D农业合作协会有限公司 | Electronics automatic injection device |
EP3498322B1 (en) * | 2012-10-17 | 2020-09-30 | Oval Medical Technologies Limited | Automatic drug delivery devices |
JP5391323B1 (en) * | 2012-10-23 | 2014-01-15 | 有限会社ミューコム | Biologic injection device |
TWI489232B (en) * | 2012-11-14 | 2015-06-21 | Inst Information Industry | Remote monitoring systems and related methods and recording mediums thereof |
US9179260B2 (en) | 2012-12-03 | 2015-11-03 | Mylan Inc. | Medicament information system and method |
US9643770B2 (en) | 2012-12-03 | 2017-05-09 | Mylan Inc. | System and method for medicament storage, dispensing, and administration |
US9692829B2 (en) | 2012-12-03 | 2017-06-27 | Mylan Inc. | Medication delivery system and method |
US20140155827A1 (en) * | 2012-12-03 | 2014-06-05 | Mylan, Inc. | Medicament information system and method |
CA2896708A1 (en) | 2012-12-27 | 2014-07-03 | Kaleo, Inc. | Devices, systems and methods for locating and interacting with medicament delivery systems |
US9421323B2 (en) | 2013-01-03 | 2016-08-23 | Medimop Medical Projects Ltd. | Door and doorstop for portable one use drug delivery apparatus |
RU2661786C2 (en) | 2013-01-16 | 2018-07-19 | Байер Фарма Акциенгезельшафт | Locking mechanism of drug injection device |
US10105487B2 (en) | 2013-01-24 | 2018-10-23 | Chrono Therapeutics Inc. | Optimized bio-synchronous bioactive agent delivery system |
EP2953667B1 (en) | 2013-02-11 | 2019-10-23 | Antares Pharma, Inc. | Needle assisted jet injection device having reduced trigger force |
US9707354B2 (en) | 2013-03-11 | 2017-07-18 | Antares Pharma, Inc. | Multiple dosage injector with rack and pinion dosage system |
WO2014165136A1 (en) | 2013-03-12 | 2014-10-09 | Antares Pharma, Inc. | Constant volume prefilled syringes and kits thereof |
US10143830B2 (en) * | 2013-03-13 | 2018-12-04 | Crisi Medical Systems, Inc. | Injection site information cap |
US9173998B2 (en) | 2013-03-14 | 2015-11-03 | Tandem Diabetes Care, Inc. | System and method for detecting occlusions in an infusion pump |
WO2017062005A1 (en) * | 2015-10-08 | 2017-04-13 | Windgap Medical | Portable drug mixing and delivery device and associated methods |
EP3593839A1 (en) | 2013-03-15 | 2020-01-15 | Amgen Inc. | Drug cassette |
US10350409B2 (en) * | 2013-03-15 | 2019-07-16 | Ottfried Waldenburg | Instrument for and method of treating venomous bites |
WO2016028814A2 (en) | 2014-08-18 | 2016-02-25 | Windgap Medical, Inc | Portable drug mixing and delivery device and associated methods |
US9907910B2 (en) | 2013-03-15 | 2018-03-06 | Windgap Medical, Inc. | Portable drug mixing and delivery device and associated methods |
TWI580451B (en) | 2013-03-15 | 2017-05-01 | 安美基公司 | Cassette for an injector and method of using an autoinjector apparatus having an autoinjector and a cassette |
JP6422479B2 (en) * | 2013-03-15 | 2018-11-14 | ハイプロテック、 インク. | Multi-chamber injection device |
US10569017B2 (en) | 2013-03-15 | 2020-02-25 | Windgap Medical, Inc. | Portable drug mixing and delivery device and associated methods |
JP6560187B2 (en) | 2013-03-15 | 2019-08-14 | ウインドギャップ メディカル インコーポレイテッド | Portable drug mixing and delivery system and method |
EP2784766A1 (en) | 2013-03-28 | 2014-10-01 | F. Hoffmann-La Roche AG | Training device for medicine injection devices and reset device for resetting such a training device |
US9011164B2 (en) | 2013-04-30 | 2015-04-21 | Medimop Medical Projects Ltd. | Clip contact for easy installation of printed circuit board PCB |
GB2503556B (en) * | 2013-04-30 | 2014-07-02 | Meditech Endoscopy Ltd | Container |
US9889256B2 (en) | 2013-05-03 | 2018-02-13 | Medimop Medical Projects Ltd. | Sensing a status of an infuser based on sensing motor control and power input |
US9075906B2 (en) * | 2013-06-28 | 2015-07-07 | Elwha Llc | Medical support system including medical equipment case |
US9838645B2 (en) | 2013-10-31 | 2017-12-05 | Elwha Llc | Remote monitoring of telemedicine device |
FR3011824B1 (en) * | 2013-10-15 | 2016-05-13 | Aptar France Sas | DEVICE FOR PACKAGING A FLUID PRODUCT DISPENSER. |
WO2015154049A1 (en) | 2014-04-04 | 2015-10-08 | Altaviz, Llc | Intraocular lens inserter |
AU2015252344B2 (en) | 2014-05-02 | 2016-12-15 | Shl Medical Ag | Medicament delivery device |
JP6817074B2 (en) | 2014-06-03 | 2021-01-20 | アムジエン・インコーポレーテツド | Controllable drug delivery system and usage |
CA2952167C (en) | 2014-06-13 | 2023-06-13 | Aterica Inc. | System and device for management of medication delivery devices |
US9517307B2 (en) | 2014-07-18 | 2016-12-13 | Kaleo, Inc. | Devices and methods for delivering opioid antagonists including formulations for naloxone |
US11116903B2 (en) | 2014-08-18 | 2021-09-14 | Windgap Medical, Inc | Compression seal for use with a liquid component storage vial of an auto-injector |
US10327679B2 (en) | 2014-09-03 | 2019-06-25 | Nova Biomedical Corporation | Subcutaneous sensor inserter and method |
US10704944B2 (en) | 2014-09-14 | 2020-07-07 | Becton, Dickinson And Company | System and method for capturing dose information |
US10971260B2 (en) | 2014-09-14 | 2021-04-06 | Becton, Dickinson And Company | System and method for capturing dose information |
WO2016055290A2 (en) * | 2014-10-06 | 2016-04-14 | Carebay Europe Ltd | Information provider system |
EP3021245A1 (en) * | 2014-10-06 | 2016-05-18 | Carebay Europe Ltd. | Information provider system |
BR112017008009A2 (en) * | 2014-10-18 | 2017-12-19 | Abbvie Inc | apparatus and usable automatic injection system |
KR101931459B1 (en) * | 2014-11-20 | 2018-12-20 | 케어베이 유럽 리미티드 | Medicament delivery device |
JP2017538731A (en) | 2014-12-18 | 2017-12-28 | ウィンドギャップ メディカル, インコーポレイテッド | Methods and compositions for dissolving or solubilizing therapeutic agents. |
US11357916B2 (en) | 2014-12-19 | 2022-06-14 | Amgen Inc. | Drug delivery device with live button or user interface field |
EP3233163B1 (en) | 2014-12-19 | 2021-10-13 | Amgen Inc. | Drug delivery device with proximity sensor |
WO2016098060A1 (en) * | 2014-12-19 | 2016-06-23 | Medaxor Pty Ltd | Multi-use injection system |
US9333289B1 (en) | 2015-01-16 | 2016-05-10 | Plas-Tech Engineering, Inc. | Tamper evident closure container |
WO2016123406A1 (en) | 2015-01-28 | 2016-08-04 | Chrono Therapeutics Inc. | Drug delivery methods and systems |
EP3258995A4 (en) | 2015-02-20 | 2018-12-12 | Regeneron Pharmaceuticals, Inc. | Syringe systems, piston seal systems, stopper systems, and methods of use and assembly |
US10251813B2 (en) | 2015-03-04 | 2019-04-09 | West Pharma. Services IL, Ltd. | Flexibly mounted cartridge alignment collar for drug delivery device |
US9795534B2 (en) | 2015-03-04 | 2017-10-24 | Medimop Medical Projects Ltd. | Compliant coupling assembly for cartridge coupling of a drug delivery device |
JP6799001B2 (en) | 2015-03-10 | 2020-12-09 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | Injection device |
CA2977814A1 (en) | 2015-03-12 | 2016-09-15 | Chrono Therapeutics Inc. | Craving input and support system |
CA2980004C (en) | 2015-03-24 | 2023-10-10 | Kaleo, Inc. | Devices and methods for delivering a lyophilized medicament |
US9744297B2 (en) | 2015-04-10 | 2017-08-29 | Medimop Medical Projects Ltd. | Needle cannula position as an input to operational control of an injection device |
US10293120B2 (en) | 2015-04-10 | 2019-05-21 | West Pharma. Services IL, Ltd. | Redundant injection device status indication |
AU2016266657B2 (en) | 2015-04-15 | 2020-09-17 | Windgap Medical, Llc | Removable actuating cap for use with an auto-injector assembly |
US9818274B2 (en) | 2015-05-28 | 2017-11-14 | Invue Security Products Inc. | Merchandise security system with optical communication |
US10149943B2 (en) | 2015-05-29 | 2018-12-11 | West Pharma. Services IL, Ltd. | Linear rotation stabilizer for a telescoping syringe stopper driverdriving assembly |
US11207465B2 (en) | 2015-06-04 | 2021-12-28 | West Pharma. Services Il. Ltd. | Cartridge insertion for drug delivery device |
GB2556479B (en) | 2015-06-30 | 2022-09-07 | Kaleo Inc | Auto-injectors for administration of a medicament within a prefilled syringe |
KR102018997B1 (en) * | 2015-07-07 | 2019-09-05 | 브라이터 에이비 (피유비엘) | Methods for Monitoring Medical Devices |
RU2738578C2 (en) | 2015-07-20 | 2020-12-14 | Перл Терапьютикс, Инк. | Aerosol delivery systems and corresponding methods |
EP3313478B1 (en) | 2015-08-13 | 2020-11-04 | Windgap Medical, Inc. | Mixing and injection device with sterility features |
EP3141275A1 (en) * | 2015-09-14 | 2017-03-15 | Carebay Europe Ltd. | Medicament delivery device |
US10576207B2 (en) | 2015-10-09 | 2020-03-03 | West Pharma. Services IL, Ltd. | Angled syringe patch injector |
US9987432B2 (en) | 2015-09-22 | 2018-06-05 | West Pharma. Services IL, Ltd. | Rotation resistant friction adapter for plunger driver of drug delivery device |
CH711618A2 (en) | 2015-10-07 | 2017-04-13 | Tecpharma Licensing Ag | Administration device with activatable identification means. |
JP7017512B2 (en) | 2015-10-09 | 2022-02-08 | ウェスト ファーマ サービシーズ イスラエル リミテッド | Bending fluid path type accessories for filled fluid containers |
US10172706B2 (en) | 2015-10-31 | 2019-01-08 | Novartis Ag | Intraocular lens inserter |
AU2016353345B2 (en) | 2015-11-12 | 2021-12-23 | University Of Virginia Patent Foundation | Compositions and methods for vas-occlusive contraception and reversal thereof |
WO2017087888A1 (en) | 2015-11-18 | 2017-05-26 | President And Fellows Of Harvard College | Systems and methods for monitoring, managing, and treating asthma and anaphylaxis |
WO2017151197A1 (en) * | 2015-11-24 | 2017-09-08 | Aktivax, Inc. | Pressure cartridge and activation mechanism |
WO2017093198A1 (en) | 2015-11-30 | 2017-06-08 | Sanofi-Aventis Deutschland Gmbh | Packaging assembly |
MX2018006652A (en) | 2015-11-30 | 2019-06-20 | Sanofi Aventis Deutschland | Packaging assembly with mounting attachment. |
US9836930B2 (en) * | 2015-12-31 | 2017-12-05 | Create Technologies, Inc. | Method of making and using a tactile array device |
CN113041432B (en) | 2016-01-21 | 2023-04-07 | 西医药服务以色列有限公司 | Medicament delivery device comprising a visual indicator |
EP3711793B1 (en) | 2016-01-21 | 2021-12-01 | West Pharma Services IL, Ltd. | A method of connecting a cartridge to an automatic injector |
JP6542481B2 (en) | 2016-01-21 | 2019-07-10 | ウェスト ファーマ サービシーズ イスラエル リミテッド | system |
US11389597B2 (en) | 2016-03-16 | 2022-07-19 | West Pharma. Services IL, Ltd. | Staged telescopic screw assembly having different visual indicators |
EP3463526A1 (en) | 2016-06-02 | 2019-04-10 | West Pharma. Services Il, Ltd. | Three position needle retraction |
GB2565978B (en) | 2016-06-06 | 2022-03-02 | E3D Agricultural Cooporative Association Ltd | Multiple use computerized injector |
EP3490638A4 (en) * | 2016-07-29 | 2020-01-22 | Alcyone Lifesciences, Inc. | Automated drug delivery systems and methods |
JP6869327B2 (en) | 2016-08-01 | 2021-05-12 | ウェスト ファーマ サービシーズ イスラエル リミテッド | Anti-rotation cartridge |
JP7059251B2 (en) | 2016-08-01 | 2022-04-25 | ウェスト ファーマ サービシーズ イスラエル リミテッド | A spring that prevents the door from closing halfway |
US20180070753A1 (en) * | 2016-09-15 | 2018-03-15 | Ryan James Eveloff | Receptacle Security System |
EP3525843B1 (en) * | 2016-10-11 | 2020-10-21 | Phillips-Medisize A/S | Auto injector with automated reconstitution |
US11224689B2 (en) * | 2016-10-17 | 2022-01-18 | Carefusion 303, Inc. | Systems and methods for guided relay delivery of medication |
US10661015B2 (en) | 2016-10-31 | 2020-05-26 | Summit Street Medical LLC | Wearable drug delivery device |
EP3544658A1 (en) | 2016-11-22 | 2019-10-02 | Sorrel Medical Ltd. | Apparatus for delivering a therapeutic substance |
EP3558420A4 (en) * | 2016-12-23 | 2020-05-27 | Kaleo, Inc. | Medicament delivery device and methods for delivering drugs to infants and children |
US9636460B1 (en) | 2016-12-28 | 2017-05-02 | Creare Llc | Pneumatic autoinjector with automated mixing |
CN110381854A (en) | 2017-01-05 | 2019-10-25 | 考恩特兰有限公司 | Method for being implanted into and reversing stimulating responsive implantation material |
EP3565617A1 (en) | 2017-01-06 | 2019-11-13 | Chrono Therapeutics Inc. | Transdermal drug delivery devices and methods |
EP3345637B1 (en) * | 2017-01-09 | 2020-03-18 | Verily Life Sciences LLC | Systems and methods for wearable emergency drug injection devices |
US11000367B2 (en) | 2017-01-13 | 2021-05-11 | Alcon Inc. | Intraocular lens injector |
WO2018136413A2 (en) * | 2017-01-17 | 2018-07-26 | Kaleo, Inc. | Medicament delivery devices with wireless connectivity and event detection |
WO2018154033A1 (en) * | 2017-02-24 | 2018-08-30 | Sanofi | Packaging assembly |
US11565034B2 (en) | 2017-02-24 | 2023-01-31 | Sanofi | Packaging assembly |
CA3050927A1 (en) | 2017-03-06 | 2018-09-13 | Brian Stonecipher | Drug delivery device with activation prevention feature |
WO2018166701A1 (en) | 2017-03-16 | 2018-09-20 | Novartis Ag | Injector device |
WO2018166703A1 (en) | 2017-03-16 | 2018-09-20 | Novartis Ag | Needle ejection and retraction mechanism and injector device |
CN115025328A (en) | 2017-05-05 | 2022-09-09 | 里珍纳龙药品有限公司 | Auto-injectors and related methods of use |
WO2018213543A1 (en) * | 2017-05-18 | 2018-11-22 | Kuehn Christopher Joseph | Planar auto injection system |
AU2018271998B2 (en) * | 2017-05-25 | 2024-03-07 | Enable Injections, Inc. | Medical fluid transfer and injection apparatus and method with compliance monitoring |
CN110869072B (en) | 2017-05-30 | 2021-12-10 | 西部制药服务有限公司(以色列) | Modular drive mechanism for a wearable injector |
KR102164791B1 (en) * | 2017-06-02 | 2020-10-15 | 주식회사 아이센스 | Sensor and applicator assembly for continuous glucose monitoring system |
WO2019071129A1 (en) * | 2017-10-05 | 2019-04-11 | Pirouette Medical LLC | Protective case for an auto-injector |
WO2019079174A1 (en) * | 2017-10-16 | 2019-04-25 | Becton, Dickinson And Company | Sterilization arrangement for drug delivery device |
WO2019079474A1 (en) * | 2017-10-17 | 2019-04-25 | Jeff Baker | Injection training device |
JP6920555B2 (en) * | 2017-12-15 | 2021-08-18 | イーライ リリー アンド カンパニー | Drug delivery device with syringe detection system |
AU2018386657A1 (en) | 2017-12-21 | 2020-07-02 | Inject Pharma Sweden Ab | Auto injector for oxygen reduced packaging |
CN114470420A (en) | 2017-12-22 | 2022-05-13 | 西氏医药包装(以色列)有限公司 | Syringe adapted for cartridges of different sizes |
WO2019182745A1 (en) | 2018-03-19 | 2019-09-26 | Bryn Pharma, LLC | Epinephrine spray formulations |
KR102107578B1 (en) * | 2018-05-02 | 2020-05-07 | 주식회사 피테크 | Constant velocity infusion device for painless syringe and painless sylinge having the same |
KR102104080B1 (en) * | 2018-05-02 | 2020-04-23 | 주식회사 피테크 | Sonic vibration device for painless syringe and painless sylinge having the same |
DE102018111998A1 (en) * | 2018-05-18 | 2019-11-21 | Mack Rides Gmbh & Co. Kg | Sensors for the early detection of physical changes |
CA3101966A1 (en) | 2018-05-29 | 2019-12-05 | Morningside Venture Investments Limited | Drug delivery methods and systems |
JP7194756B2 (en) | 2018-06-08 | 2022-12-22 | アンタレス・ファーマ・インコーポレーテッド | auto-insertion syringe |
US20190381236A1 (en) * | 2018-06-18 | 2019-12-19 | Omar-Samir M. Badr | Autoinjector carrier |
US20200009324A1 (en) * | 2018-07-09 | 2020-01-09 | Verily Life Sciences Llc | Systems and methods for triggering a drug injection device |
WO2020018433A1 (en) | 2018-07-16 | 2020-01-23 | Kaleo, Inc. | Medicament delivery devices with wireless connectivity and compliance detection |
CA3219286A1 (en) | 2018-10-03 | 2020-04-09 | Eli Lilly And Company | Status sensing systems within an injection device assembly |
KR102199724B1 (en) * | 2018-10-05 | 2021-01-07 | 주식회사 피테크 | Painless injection device without needle |
EP3632487A1 (en) | 2018-10-05 | 2020-04-08 | Sorrel Medical Ltd. | Triggering sequence |
CN113226418B (en) * | 2018-10-23 | 2023-12-01 | 阿克提夫阿克斯公司 | Intranasal pressure drug delivery device |
EP3880273A4 (en) | 2018-11-13 | 2022-08-24 | Contraline, Inc. | Systems and methods for delivering biomaterials |
US10736037B2 (en) | 2018-12-26 | 2020-08-04 | Tandem Diabetes Care, Inc. | Methods of wireless communication in an infusion pump system |
US11806511B2 (en) * | 2019-03-13 | 2023-11-07 | Amana Fujikawa | Auto injector device |
KR102237092B1 (en) * | 2019-04-30 | 2021-04-13 | 주식회사 아이센스 | Applicator for continuous glucose monitoring system |
JP2022543523A (en) | 2019-08-09 | 2022-10-13 | カレオ,インコーポレイテッド | Device and method for delivery of substances in pre-filled syringes |
CN115461028A (en) * | 2020-03-05 | 2022-12-09 | 武田药品工业株式会社 | Medical fluid delivery device |
FR3110392A1 (en) * | 2020-05-20 | 2021-11-26 | Eveon | DRUG PREPARATION AND DISTRIBUTION DEVICE |
US10898655B1 (en) | 2020-07-30 | 2021-01-26 | Benson Eric Wengreen | Auto-injectors featuring medicine delivery assurance |
WO2022251749A2 (en) * | 2021-05-28 | 2022-12-01 | Windgap Medical, Inc | Reciprocating mixing and injector system |
WO2022256807A1 (en) * | 2021-06-02 | 2022-12-08 | Falco Medical, Llc | Compact auto-injector device |
WO2023031065A2 (en) * | 2021-08-30 | 2023-03-09 | Medicaltree Patents Ltd. | Drug delivery system |
WO2023031062A2 (en) * | 2021-08-30 | 2023-03-09 | Medicaltree Patents Ltd | Drug delivery system |
WO2023031063A1 (en) * | 2021-08-30 | 2023-03-09 | Medicaltree Patents Ltd. | Drug delivery system |
US11577020B1 (en) | 2021-10-13 | 2023-02-14 | Caden Haas | Protective case for insulin infusion set |
WO2023079392A1 (en) * | 2021-11-04 | 2023-05-11 | Janssen Research & Development, Llc | Light-based visual cueing of medication delivery instructions |
USD1007676S1 (en) | 2021-11-16 | 2023-12-12 | Regeneron Pharmaceuticals, Inc. | Wearable autoinjector |
WO2023196268A1 (en) * | 2022-04-06 | 2023-10-12 | Meridian Medical Technologies, Llc | Auto-injector system |
WO2024019938A1 (en) * | 2022-07-18 | 2024-01-25 | Medphlow, Llc | Integrated cartridge assembly for administration of drugs |
WO2024052239A1 (en) * | 2022-09-06 | 2024-03-14 | Shl Medical Ag | Dosing apparatus for parenteral delivery of fluids |
Family Cites Families (668)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2277907A (en) | 1940-08-15 | 1942-03-31 | Bell Telephone Labor Inc | Telephone set |
US2409656A (en) | 1945-04-20 | 1946-10-22 | Harold S Austin | Hypodermic syringe |
US2960087A (en) | 1954-02-16 | 1960-11-15 | Auguste Rooseboom | Hypodermic injection apparatus |
US3055362A (en) | 1956-05-16 | 1962-09-25 | Auguste Rooseboom | Hypodermic injection apparatus |
US3115133A (en) | 1962-05-15 | 1963-12-24 | Morando Emilio Donald | Needleless prefilled disposable hypodermic injector |
FR1514210A (en) | 1966-12-26 | 1968-02-23 | Automatic hypodermic syringe | |
US3426448A (en) | 1967-02-02 | 1969-02-11 | Stanley J Sarnoff | Training injection device |
US3563373A (en) | 1967-10-06 | 1971-02-16 | Paul E Paulson | Hypodermic syringe assembly |
US3565070A (en) | 1969-02-28 | 1971-02-23 | Riker Laboratories Inc | Inhalation actuable aerosol dispenser |
US3688765A (en) | 1969-10-03 | 1972-09-05 | Jack S Gasaway | Hypodermic injection device |
DE2019296A1 (en) | 1970-04-22 | 1971-11-04 | Walter Dr Stein | Injection device, in particular injection syringe with portioned pack |
US3768472A (en) | 1972-02-07 | 1973-10-30 | M Hodosh | Fluid dispensing gun |
BE795162A (en) | 1972-02-10 | 1973-08-08 | Philips Nv | INJEKTIE-INRICHTING |
JPS5121295Y2 (en) | 1972-10-07 | 1976-06-03 | ||
US3795061A (en) | 1973-03-21 | 1974-03-05 | Survival Technology | Training injector |
JPS5121295U (en) * | 1974-08-03 | 1976-02-17 | ||
US3945379A (en) | 1974-08-08 | 1976-03-23 | Smithkline Corporation | Injection device |
JPS5422316Y2 (en) * | 1974-08-15 | 1979-08-03 | ||
JPS5121295A (en) | 1974-08-15 | 1976-02-20 | Uozu Mfg | NARAIKAKOSOCHI |
US3941130A (en) | 1975-03-18 | 1976-03-02 | Tibbs Robert C | Sequential trigger release for injection device |
US4031889A (en) | 1975-03-25 | 1977-06-28 | William Floyd Pike | Power operated aspirating hypodermic syringe |
FR2348709A1 (en) | 1976-04-23 | 1977-11-18 | Pistor Michel | MESOTHERAPIC TREATMENT PROCESS AND INJECTION DEVICE, FORMING AUTOMATIC MICRO-INJECTOR, INCLUDING APPLICATION |
US4086062A (en) | 1977-02-23 | 1978-04-25 | Hach Chemical Company | Digital titration device |
US4124024A (en) | 1977-03-03 | 1978-11-07 | Schwebel Paul R | Disposable hypodermic injection ampule |
NO140145C (en) | 1977-04-06 | 1979-07-11 | Elkem Spigerverket As | DEVICE AT LOAD. |
US4249255A (en) | 1978-11-30 | 1981-02-03 | Rca Corporation | Continuous tuning arrangement for a multiband television receiver |
US4227528A (en) | 1978-12-26 | 1980-10-14 | Wardlaw Stephen C | Automatic disposable hypodermic syringe |
US4226235A (en) * | 1979-01-25 | 1980-10-07 | Survival Technology, Inc. | Plural injecting device |
US4360019A (en) | 1979-02-28 | 1982-11-23 | Andros Incorporated | Implantable infusion device |
US4258713A (en) | 1979-07-23 | 1981-03-31 | Wardlaw Stephen C | Automatic disposable hypodermic syringe |
FR2506161A1 (en) | 1981-05-20 | 1982-11-26 | Alsetex Armement | Self:injection syringe with compartments for specific liquids - is spring:loaded first to penetrate patient then inject liq.(s), is automatic |
FR2509615B1 (en) | 1981-07-15 | 1985-07-19 | Merieux Inst | DEVICE FOR SELF-INJECTION OF SUBSTANCES, ESPECIALLY MEDICINAL PRODUCTS |
US4394863A (en) | 1981-10-23 | 1983-07-26 | Survival Technology, Inc. | Automatic injector with cartridge having separate sequentially injectable medicaments |
US4378015A (en) | 1981-12-21 | 1983-03-29 | Wardlaw Stephen C | Automatic injecting syringe |
JPS58116363A (en) * | 1981-12-28 | 1983-07-11 | 瀬戸 米蔵 | Multi-cylinder type liquid supply apparatus |
US4424057A (en) | 1982-04-01 | 1984-01-03 | House Hugh A | Wet-dry syringe |
US4441629A (en) | 1982-08-10 | 1984-04-10 | Mackal Glenn H | Compressed gas powered caulking gun |
US4673657A (en) | 1983-08-26 | 1987-06-16 | The Regents Of The University Of California | Multiple assay card and system |
US4484910A (en) | 1983-12-21 | 1984-11-27 | Survival Technology, Inc. | Dual mode automatic injector |
US4573976A (en) | 1984-05-24 | 1986-03-04 | Dolores A. Smith | Shielded needle |
FR2567760A1 (en) * | 1984-07-18 | 1986-01-24 | Hibon Joseph | APPARATUS FOR EXECUTING SERIES OF DRUG INJECTIONS |
US4795433A (en) * | 1985-05-20 | 1989-01-03 | Survival Technology, Inc. | Automatic injector for emergency treatment |
US4613328A (en) | 1984-10-22 | 1986-09-23 | Cecil Boyd | Bio-medical injector apparatus |
ATE39325T1 (en) | 1984-11-02 | 1989-01-15 | Duphar Int Res | AUTOMATIC INJECTION DEVICE. |
US4617557A (en) | 1984-11-08 | 1986-10-14 | National Patent Development Corporation | Medication compliance aid for unit dose packaging |
FR2573310B1 (en) | 1984-11-20 | 1988-12-30 | Poutrait Morin | BULB FOR HYPODERMIC SYRINGE, IN PARTICULAR SELF-INJECTING SYRINGE |
US4666430A (en) | 1984-12-05 | 1987-05-19 | I-Flow Corporation | Infusion pump |
US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
SE451295B (en) | 1985-03-27 | 1987-09-28 | Fagersta El & Diesel Ab | OGONDUSCH |
US4689042A (en) | 1985-05-20 | 1987-08-25 | Survival Technology, Inc. | Automatic medicament ingredient mixing and injecting apparatus |
US4610666A (en) | 1985-06-24 | 1986-09-09 | Pizzino Joanne L | Dual syringe |
DE3673317D1 (en) | 1985-10-11 | 1990-09-13 | Duphar Int Res | AUTOMATIC SYRINGE. |
US4640686A (en) | 1986-02-24 | 1987-02-03 | Survival Technology, Inc. | Audible signal autoinjector training device |
US4664653A (en) | 1986-02-24 | 1987-05-12 | Sagstetter William E | Manually operated reusable injection apparatus |
ATE67414T1 (en) | 1986-05-15 | 1991-10-15 | Duphar Int Res | AUTOMATIC INJECTION SYRINGE. |
DE3622399A1 (en) | 1986-07-01 | 1988-02-04 | Eberhardt Schlueter | AUTOMATIC INJECTION DEVICE AND AMPOULE OR CARTRIDGE FOR AN INJECTION DEVICE |
GB2195544A (en) | 1986-08-04 | 1988-04-13 | Universal Precision Moulders L | Inhaler |
US4693708A (en) | 1986-10-16 | 1987-09-15 | Wanderer Alan A | Combination needle shield/needle guard device for a hypodermic syringe with a permanently attached needle |
US4782841A (en) | 1987-04-07 | 1988-11-08 | Icu Medical, Inc. | Medical device |
SE457417B (en) | 1987-04-14 | 1988-12-27 | Astra Meditec Ab | AUTOMATIC SQUARE SPRAY, PROCEDURE FOR MIXING AND INJECTION WITH THE SPRAYER AND AMPULA FOR PRIVATE CHAMBER SPRAY |
DE3715340C2 (en) | 1987-05-08 | 1995-10-19 | Haselmeier Wilhelm Fa | Injection device |
DE3715258C2 (en) | 1987-05-08 | 1996-10-31 | Haselmeier Wilhelm Fa | Injection device |
US4865582A (en) | 1987-06-05 | 1989-09-12 | Drug Delivery Systems Inc. | Disposable transdermal drug applicators |
US4790824A (en) * | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
ATA228987A (en) | 1987-09-09 | 1993-07-15 | Pickhard Ewald | INJECTION DEVICE WITH A DEFORMABLE Vial |
US4874382A (en) | 1987-10-15 | 1989-10-17 | Servetus Partnership | Safety syringe |
US4781697A (en) | 1987-12-04 | 1988-11-01 | Robert Slaughter | Removable protective shield for needle sheath |
US4853521A (en) | 1987-12-28 | 1989-08-01 | Claeys Ronald W | System for verifying and recording drug administration to a patient |
US4826489A (en) | 1988-01-14 | 1989-05-02 | Habley Medical Technology Corporation | Disposable safety syringe having means for retracting its needle cannula into its medication cartridge |
ES2024564B3 (en) | 1988-02-16 | 1992-03-01 | Arzneimittel Gmbh Apotheker Vetter & Co Ravensburg | SYRINGE FOR MEDICINAL PURPOSES |
GB8809115D0 (en) | 1988-04-18 | 1988-05-18 | Turner R C | Syringes |
US4959056A (en) | 1988-06-14 | 1990-09-25 | Wayne State University | Digital dispenser |
US4894054A (en) | 1988-06-20 | 1990-01-16 | Miskinyar Shir A | Preloaded automatic disposable syringe |
US4906235A (en) | 1988-08-22 | 1990-03-06 | Roberts Christopher W | Needle guard |
USRE35986E (en) | 1988-08-23 | 1998-12-08 | Meridian Medical Technologies, Inc. | Multiple chamber automatic injector |
GB8819977D0 (en) | 1988-08-23 | 1988-09-21 | Medimech Ltd | Automatic injectors |
US5024656A (en) | 1988-08-30 | 1991-06-18 | Injet Medical Products, Inc. | Gas-pressure-regulated needleless injection system |
US4915695A (en) | 1988-09-12 | 1990-04-10 | Koobs David C | Multiple barrel syringe |
US5244465A (en) | 1988-10-19 | 1993-09-14 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Reusable injection device for distributing a preselected dose |
DK0390244T3 (en) | 1989-03-28 | 1993-02-08 | Duphar Int Res | Pre-filled injection device comprising a cylinder in which a liquid diazepam formulation is included |
US5038023A (en) | 1989-06-28 | 1991-08-06 | C. Itoh Information Systems Development, Inc. | System for storing and monitoring bar coded articles such as keys in a drawer |
US6096005A (en) | 1989-07-11 | 2000-08-01 | Mdc Investment Holdings, Inc. | Retractable needle medical devices |
US5085642A (en) | 1989-07-17 | 1992-02-04 | Survival Technology, Inc. | Conveniently carried frequent use autoinjector |
DE3924830A1 (en) | 1989-07-27 | 1991-02-07 | Vetter & Co Apotheker | SYRINGE CYLINDER FOR MEDICAL PURPOSES |
NL8902456A (en) | 1989-10-03 | 1991-05-01 | Advanced Protective Injection | INJECTION SYRINGE WITH AUTOMATIC RETIRABLE NEEDLE. |
EP0423864A1 (en) | 1989-10-16 | 1991-04-24 | Duphar International Research B.V | Training device for an automatic injector |
EP0425003A1 (en) | 1989-10-24 | 1991-05-02 | Duphar International Research B.V | Training device for an automatic injector |
US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
US5642731A (en) | 1990-01-17 | 1997-07-01 | Informedix, Inc. | Method of and apparatus for monitoring the management of disease |
US5752235A (en) | 1990-01-17 | 1998-05-12 | Informedix, Inc. | Electronic medication monitoring and dispensing method |
DE59001705D1 (en) * | 1990-02-07 | 1993-07-15 | Vetter & Co Apotheker | DOUBLE CHAMBER SYRINGE AND METHOD OF USE. |
US5356376A (en) | 1990-03-08 | 1994-10-18 | Zoran Milijasevic | Flow controllers for fluid infusion sets |
US5000736A (en) | 1990-03-22 | 1991-03-19 | Harry Kaufhold, Jr. | Disposable syringe with automatic needle retraction |
US5125898A (en) | 1990-03-22 | 1992-06-30 | Harry Kaufhold, Jr. | Disposable syringe with automatic needle retraction |
ATE251929T1 (en) | 1990-03-30 | 2003-11-15 | Alza Corp | IONTOPHORETIC ADMINISTRATION DEVICE |
US5092843A (en) | 1990-04-12 | 1992-03-03 | Survival Technology, Inc. | Dispersion multichamber auto-injector |
US5336180A (en) | 1990-04-24 | 1994-08-09 | Science Incorporated | Closed drug delivery system |
US5062603A (en) | 1990-04-25 | 1991-11-05 | Dow Brands Inc. | Vacuum drum purge method and apparatus |
US5527288A (en) | 1990-12-13 | 1996-06-18 | Elan Medical Technologies Limited | Intradermal drug delivery device and method for intradermal delivery of drugs |
US5240146A (en) | 1990-12-14 | 1993-08-31 | Smedley William H | Variable proportion dispenser |
US5286258A (en) | 1991-03-08 | 1994-02-15 | Habley Medical Technology Corporation | Multipharmaceutical delivery system |
US5360410A (en) * | 1991-01-16 | 1994-11-01 | Senetek Plc | Safety syringe for mixing two-component medicaments |
US5404871A (en) | 1991-03-05 | 1995-04-11 | Aradigm | Delivery of aerosol medications for inspiration |
US5469750A (en) * | 1991-03-05 | 1995-11-28 | Aradigm Corporation | Method and apparatus for sensing flow in two directions and automatic calibration thereof |
US5199949A (en) | 1991-03-08 | 1993-04-06 | Habley Medical Technology Corp. | Multiple pharmaceutical syringe |
US5298023A (en) | 1991-03-08 | 1994-03-29 | Habley Medical Technology Corporation | Multiple pharmaceutical dispenser with accumulator |
IT223172Z2 (en) | 1991-04-09 | 1995-06-13 | Tecnomedica Ricerche Srl | DEVICE FOR THE ADMINISTRATION OF DRUGS, PARTICULARLY TWO-COMPONENT PHARMA-CI |
DK68991D0 (en) | 1991-04-17 | 1991-04-17 | Novo Nordisk As | HEADER |
US5868711A (en) | 1991-04-29 | 1999-02-09 | Board Of Regents, The University Of Texas System | Implantable intraosseous device for rapid vascular access |
US5451210A (en) | 1991-04-29 | 1995-09-19 | Lifequest Medical, Inc. | System and method for rapid vascular drug delivery |
US5405362A (en) | 1991-04-29 | 1995-04-11 | The Board Of Regents For The University Of Texas System | Interactive external defibrillation and drug injection system |
US5167641A (en) | 1991-05-29 | 1992-12-01 | Arnis, Inc. | Auto-retracting needle injector system |
DE4127650C1 (en) | 1991-08-21 | 1993-02-25 | Arzneimittel Gmbh Apotheker Vetter & Co Ravensburg, 7980 Ravensburg, De | |
US5363842A (en) | 1991-12-20 | 1994-11-15 | Circadian, Inc. | Intelligent inhaler providing feedback to both patient and medical professional |
GB9200219D0 (en) | 1992-01-07 | 1992-02-26 | Medimech Int Ltd | Automatic injectors |
US5417660A (en) | 1992-02-03 | 1995-05-23 | T. A. Kershenstine | Self-locking syringe holder for use with a hypodermic syringe |
US5369261A (en) | 1992-02-12 | 1994-11-29 | Shamir; Harry | Multi-color information encoding system |
EP0562671B1 (en) | 1992-03-27 | 1996-05-29 | Duphar International Research B.V | Automatic injector |
US5347453A (en) * | 1992-03-30 | 1994-09-13 | Maestre Federico A | Portable programmable medication alarm device and method and apparatus for programming and using the same |
US5271527A (en) | 1992-04-02 | 1993-12-21 | Habley Medical Technology Corporation | Reusable pharmaceutical dispenser with full stroke indicator |
US5281198A (en) | 1992-05-04 | 1994-01-25 | Habley Medical Technology Corporation | Pharmaceutical component-mixing delivery assembly |
US5615771A (en) | 1992-05-18 | 1997-04-01 | Smiths Industries Medical Systems, Inc. | Safety needle cartridge system |
WO1995025562A1 (en) | 1992-06-02 | 1995-09-28 | Alza Corporation | Electrotransport drug delivery device |
US5312326A (en) | 1992-06-02 | 1994-05-17 | Alza Corporation | Iontophoretic drug delivery apparatus |
US5354284A (en) | 1992-06-09 | 1994-10-11 | Habley Medical Technology Corporation | Multiple injection syringe system |
US5785049A (en) | 1994-09-21 | 1998-07-28 | Inhale Therapeutic Systems | Method and apparatus for dispersion of dry powder medicaments |
US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
US5569189A (en) * | 1992-09-28 | 1996-10-29 | Equidyne Systems, Inc. | hypodermic jet injector |
IL107038A (en) * | 1992-10-05 | 1997-04-15 | Senetek Plc | Medicament injectors and methods for injection using same |
US5314406A (en) | 1992-10-09 | 1994-05-24 | Symbiosis Corporation | Endoscopic electrosurgical suction-irrigation instrument |
US5224936A (en) | 1992-10-15 | 1993-07-06 | Brian Gallagher | Automatic self-protecting hypodermic needle assembly |
US5318544A (en) | 1992-10-20 | 1994-06-07 | Kerr Manufacturing Company | Metering syringe |
US5279514A (en) | 1992-11-16 | 1994-01-18 | David Lacombe | Gift with personalized audio message |
WO1994011041A1 (en) | 1992-11-19 | 1994-05-26 | R G S.A.S. Di Rosaria Galli & C. | Disposable auto-injector for prefilled syringes |
US5298024A (en) | 1992-12-28 | 1994-03-29 | Frank Richmond | Multi-liquid medicament delivery system with reflex valves |
FR2700959B1 (en) | 1993-02-02 | 1995-06-16 | Creange Alain | SYRINGE WITH INCORPORATED NEEDLE PROTECTION. |
US5387108A (en) * | 1993-02-05 | 1995-02-07 | Crowell; Christopher S. | Multi-purpose, universally applicable re-recordable, audible, message delivery system |
FR2701399B1 (en) | 1993-02-16 | 1995-03-31 | Valois | Portable spray device with actuation triggered by inhalation. |
US6002781A (en) | 1993-02-24 | 1999-12-14 | Matsushita Electric Industrial Co., Ltd. | Speaker system |
US5584815A (en) | 1993-04-02 | 1996-12-17 | Eli Lilly And Company | Multi-cartridge medication injection device |
US5344407A (en) | 1993-05-04 | 1994-09-06 | Ryan Dana W | Safety holder for pre-filled disposable syringe cartridge |
GB9310085D0 (en) | 1993-05-17 | 1993-06-30 | Reynolds David L | Syringe |
US5358489A (en) | 1993-05-27 | 1994-10-25 | Washington Biotech Corporation | Reloadable automatic or manual emergency injection system |
US5540664A (en) * | 1993-05-27 | 1996-07-30 | Washington Biotech Corporation | Reloadable automatic or manual emergency injection system |
US5846089A (en) | 1993-07-01 | 1998-12-08 | Weiss; Richard C. | Medicine container for indicating patient information |
AU7324394A (en) | 1993-07-06 | 1995-02-06 | Michael L. Earle | Bone cement delivery gun |
US5837546A (en) | 1993-08-24 | 1998-11-17 | Metrika, Inc. | Electronic assay device and method |
US5343519A (en) | 1993-09-07 | 1994-08-30 | Peter Feldman | Autodialer with pin feature |
SE9303453D0 (en) | 1993-10-20 | 1993-10-20 | Kabi Pharmacia Ab | Injection cartridge |
CA2132277C (en) | 1993-10-22 | 2005-05-10 | Giorgio Cirelli | Injection device |
GB9323121D0 (en) | 1993-11-09 | 1994-01-05 | Smiths Industries Plc | Needle protection assemblies |
US5399823A (en) | 1993-11-10 | 1995-03-21 | Minimed Inc. | Membrane dome switch with tactile feel regulator shim |
US5505192A (en) | 1993-11-12 | 1996-04-09 | New-Med Corporation | Dispenser monitoring system |
CA2129284C (en) | 1993-11-24 | 1999-03-09 | Kenneth J. Niehoff | Controlling plunger drives for fluid injection in animals |
DE4422710C1 (en) | 1994-06-29 | 1995-09-14 | Boehringer Ingelheim Kg | Inhaler with storage container for aerosol |
FR2715071B1 (en) | 1994-01-17 | 1996-03-01 | Aguettant Lab | Automatic drug injector. |
US5395345A (en) | 1994-01-27 | 1995-03-07 | The Kendall Company | Aspirating syringe |
US5478316A (en) | 1994-02-02 | 1995-12-26 | Becton, Dickinson And Company | Automatic self-injection device |
US5514097A (en) | 1994-02-14 | 1996-05-07 | Genentech, Inc. | Self administered injection pen apparatus and method |
US5522804A (en) * | 1994-02-15 | 1996-06-04 | Lynn; Lawrence A. | Aspiration, mixing, and injection syringe |
US5536249A (en) | 1994-03-09 | 1996-07-16 | Visionary Medical Products, Inc. | Pen-type injector with a microprocessor and blood characteristic monitor |
AU2192795A (en) | 1994-03-21 | 1995-10-09 | Ibv Technologies, Inc. | Programmable voice instructed medication delivery and outcomes monitoring system |
DE4412041A1 (en) | 1994-04-08 | 1995-10-12 | Pfeiffer Erich Gmbh & Co Kg | Discharge device for flowable media, in particular for discharge in just one stroke |
GB9412301D0 (en) * | 1994-06-17 | 1994-08-10 | Safe T Ltd | Hollow-needle drugs etc applicators |
US5645534A (en) | 1994-06-24 | 1997-07-08 | Becton Dickinson And Company | Time of last injection indicator for medication delivery pen |
US5876380A (en) | 1994-10-19 | 1999-03-02 | Manganini; Steven J. | Portable syringe dispenser system |
US5544647A (en) | 1994-11-29 | 1996-08-13 | Iep Group, Inc. | Metered dose inhalator |
US6030363A (en) | 1994-12-02 | 2000-02-29 | Science Incorporated | Medicament dispenser |
US5599302A (en) | 1995-01-09 | 1997-02-04 | Medi-Ject Corporation | Medical injection system and method, gas spring thereof and launching device using gas spring |
US5690618A (en) | 1995-02-22 | 1997-11-25 | Mark Timothy Smith | Electronic syringe |
US5610992A (en) | 1995-03-17 | 1997-03-11 | Hewlett-Packard Company | Portable electronic device having a ported speaker enclosure |
US5659741A (en) | 1995-03-29 | 1997-08-19 | Stuart S. Bowie | Computer system and method for storing medical histories using a carrying size card |
FR2733155B1 (en) | 1995-04-18 | 1997-09-19 | Tebro | RECHARGEABLE SELF-INJECTOR |
US6221045B1 (en) | 1995-04-20 | 2001-04-24 | Acist Medical Systems, Inc. | Angiographic injector system with automatic high/low pressure switching |
US20030028145A1 (en) | 1995-04-20 | 2003-02-06 | Duchon Douglas J. | Angiographic injector system with multiple processor redundancy |
AU5391896A (en) | 1995-04-20 | 1996-11-07 | Invasatec, Inc. | Radiographic contrast material injector |
US5772635A (en) | 1995-05-15 | 1998-06-30 | Alaris Medical Systems, Inc. | Automated infusion system with dose rate calculator |
US5809997A (en) | 1995-05-18 | 1998-09-22 | Medtrac Technologies, Inc. | Electronic medication chronolog device |
US5730723A (en) | 1995-10-10 | 1998-03-24 | Visionary Medical Products Corporation, Inc. | Gas pressured needle-less injection device and method |
CA2151407A1 (en) | 1995-06-09 | 1996-12-10 | Duncan Newman | Injection device |
DE19522786C2 (en) | 1995-06-14 | 2002-04-04 | Innovative Technik Marketing U | display device |
US5651775A (en) | 1995-07-12 | 1997-07-29 | Walker; Richard Bradley | Medication delivery and monitoring system and methods |
US5645571B1 (en) | 1995-08-01 | 1999-08-24 | Surviva Link Corp | Automated external defibrillator with lid activated self-test system |
US5558679A (en) | 1995-08-21 | 1996-09-24 | Micron Communications, Inc. | Method for mounting a battery on a substrate |
AU1860697A (en) | 1995-09-08 | 1997-07-28 | Visionary Medical Products Corporation | Pen-type injector drive mechanism |
IE77523B1 (en) | 1995-09-11 | 1997-12-17 | Elan Med Tech | Medicament delivery device |
US6080130A (en) * | 1998-11-14 | 2000-06-27 | Castellano; Thomas P. | Gas power source for a needle-less injector |
US5658259A (en) | 1995-10-19 | 1997-08-19 | Meridian Medical Technologies, Inc. | Dental cartridge assembly auto-injector with protective needle cover |
US5716348A (en) | 1995-10-19 | 1998-02-10 | Meridian Medical Technologies, Inc. | Anti-coring needle |
US5970457A (en) | 1995-10-25 | 1999-10-19 | Johns Hopkins University | Voice command and control medical care system |
US5567160A (en) | 1995-10-26 | 1996-10-22 | Survival Technology, Inc. | Autoinjector training device |
US5697916A (en) | 1995-11-21 | 1997-12-16 | Stat Medical Devices Inc. | Hypodermic dosage measuring device |
ZA9610374B (en) | 1995-12-11 | 1997-06-23 | Elan Med Tech | Cartridge-based drug delivery device |
AU2260397A (en) | 1996-01-31 | 1997-08-22 | Trustees Of The University Of Pennsylvania, The | Remote control drug delivery device |
DE19604838A1 (en) | 1996-02-12 | 1997-08-14 | Alfred Von Schuckmann | Device for dispensing liquid in divided quantities |
ES2200155T3 (en) | 1996-02-23 | 2004-03-01 | Novo Nordisk A/S | SYRINGE WITH AN ELECTRONIC REPRESENTATION OF THE PARAMETERS. |
US5865795A (en) | 1996-02-29 | 1999-02-02 | Medi-Ject Corporation | Safety mechanism for injection devices |
PL185605B1 (en) | 1996-03-12 | 2003-06-30 | Novo Nordisk As | Injection making instrument with electronic pre-setting of specific doses |
US5853292A (en) | 1996-05-08 | 1998-12-29 | Gaumard Scientific Company, Inc. | Computerized education system for teaching patient care |
US5805423A (en) | 1996-05-17 | 1998-09-08 | United Technologies Automotive | Battery contact and retention apparatus for printed circuit boards |
GB9611562D0 (en) | 1996-06-03 | 1996-08-07 | Applied Research Systems | Device |
US5848988A (en) | 1996-07-26 | 1998-12-15 | Alaris Medical Systems, Inc. | Infusion device with audible data output |
US5823363A (en) * | 1996-10-18 | 1998-10-20 | Cassel; Douglas | Medical syringe holding/transport apparatus |
US5954641A (en) | 1997-09-08 | 1999-09-21 | Informedix, Inc. | Method, apparatus and operating system for managing the administration of medication and medical treatment regimens |
US5681292A (en) | 1996-10-29 | 1997-10-28 | Retrax Safety Systems, Inc. | Retractable needle and syringe combination |
US6249717B1 (en) | 1996-11-08 | 2001-06-19 | Sangstat Medical Corporation | Liquid medication dispenser apparatus |
US5693023A (en) | 1996-11-15 | 1997-12-02 | Adventec, Inc. | Syringe with retractable needle assembly |
US6529446B1 (en) | 1996-12-20 | 2003-03-04 | Telaric L.L.C. | Interactive medication container |
US6259654B1 (en) | 1997-03-28 | 2001-07-10 | Telaric, L.L.C. | Multi-vial medication organizer and dispenser |
US5852590A (en) | 1996-12-20 | 1998-12-22 | De La Huerga; Carlos | Interactive label for medication containers and dispensers |
DE19701494A1 (en) | 1997-01-17 | 1998-07-23 | Boehringer Mannheim Gmbh | Transdermal injection system |
USD407487S (en) | 1997-02-05 | 1999-03-30 | Hoechst Marion Roussel Duetschland | Medication delivery pen |
US5860957A (en) * | 1997-02-07 | 1999-01-19 | Sarcos, Inc. | Multipathway electronically-controlled drug delivery system |
US5991655A (en) | 1997-03-03 | 1999-11-23 | Drug Delivery Systems, Inc. | Iontophoretic drug delivery device and method of manufacturing the same |
WO1998040115A1 (en) * | 1997-03-10 | 1998-09-17 | Disetronic Licensing Ag | Device for dispensing fluids |
US6270455B1 (en) | 1997-03-28 | 2001-08-07 | Health Hero Network, Inc. | Networked system for interactive communications and remote monitoring of drug delivery |
US5868713A (en) | 1997-04-03 | 1999-02-09 | L.O.M. Laboratories Inc. | Pneumatic retractable syringe |
US6530900B1 (en) | 1997-05-06 | 2003-03-11 | Elan Pharma International Limited | Drug delivery device |
US5993412A (en) | 1997-05-19 | 1999-11-30 | Bioject, Inc. | Injection apparatus |
US6454746B1 (en) | 1997-06-04 | 2002-09-24 | Eli Lilly And Company | Medication delivery apparatus |
US6077106A (en) | 1997-06-05 | 2000-06-20 | Micron Communications, Inc. | Thin profile battery mounting contact for printed circuit boards |
US6500150B1 (en) | 1997-06-16 | 2002-12-31 | Elan Pharma International Limited | Pre-filled drug-delivery device and method of manufacture and assembly of same |
CA2294612A1 (en) * | 1997-06-16 | 1998-12-23 | Elan Corporation Plc | Pre-filled drug-delivery device and method of manufacture and assembly of same |
EP0888790A1 (en) | 1997-07-04 | 1999-01-07 | PowderJect Research Limited | Drug particle delivery device |
GB9716065D0 (en) | 1997-07-31 | 1997-10-01 | Owen Mumford Ltd | Improvements relating to injection devices |
US5823346A (en) | 1997-08-04 | 1998-10-20 | Weiner; Steven L. | Medicine bottle reminder attachment |
SE9702872D0 (en) * | 1997-08-06 | 1997-08-06 | Pharmacia & Upjohn Ab | Automated delivery device and method for its operation |
CA2300930C (en) | 1997-08-21 | 2007-10-16 | Owen Mumford Limited | Improvements relating to injection devices |
WO1999010031A1 (en) | 1997-08-27 | 1999-03-04 | Farrens Frank L | Device for injecting material beneath the skin of a human or animal |
US6039713A (en) | 1997-08-28 | 2000-03-21 | Mdc Investment Holdings, Inc. | Pre-filled retractable needle injection device |
US5941857A (en) | 1997-09-12 | 1999-08-24 | Becton Dickinson And Company | Disposable pen needle |
AUPO940697A0 (en) | 1997-09-23 | 1997-10-16 | Kaal, Joseph Hermes | Retractable syringe |
US5971953A (en) | 1998-01-09 | 1999-10-26 | Bachynsky; Nicholas | Dual chamber syringe apparatus |
US6149626A (en) | 1997-10-03 | 2000-11-21 | Bachynsky; Nicholas | Automatic injecting syringe apparatus |
IE970782A1 (en) | 1997-10-22 | 1999-05-05 | Elan Corp | An improved automatic syringe |
US6086562A (en) | 1997-10-27 | 2000-07-11 | Sarcos, Inc. | Disposable automatic injection device |
US6045534A (en) | 1997-10-27 | 2000-04-04 | Sarcos, Inc. | Disposable fluid injection module |
US6285757B1 (en) | 1997-11-07 | 2001-09-04 | Via, Inc. | Interactive devices and methods |
US6015438A (en) | 1997-11-14 | 2000-01-18 | Retractable Technologies Inc. | Full displacement retractable syringe |
TW346257U (en) | 1997-11-27 | 1998-11-21 | Hon Hai Prec Ind Co Ltd | Battery seat |
JP2002508225A (en) | 1997-12-16 | 2002-03-19 | メリディアン メディカル テクノロジーズ,インコーポレイテッド | Automatic syringe |
DE29801168U1 (en) | 1998-01-24 | 1999-08-12 | Medico Dev Investment Co | Injection device |
US6358058B1 (en) | 1998-01-30 | 2002-03-19 | 1263152 Ontario Inc. | Aerosol dispensing inhaler training device |
FR2774294B1 (en) | 1998-02-04 | 2000-04-14 | Marc Brunel | DEVICE FOR AUTOMATICALLY INJECTING A DOSE OF MEDICINAL PRODUCT |
US5978230A (en) | 1998-02-19 | 1999-11-02 | Micron Communications, Inc. | Battery mounting apparatuses, electronic devices, and methods of forming electrical connections |
FI109272B (en) | 1998-02-26 | 2002-06-28 | Raimo Juselius | Intake event detector and method for detecting intake event |
US6221055B1 (en) | 1998-03-04 | 2001-04-24 | Retractable Technologies, Inc. | Retractable dental syringe |
WO1999048546A1 (en) | 1998-03-23 | 1999-09-30 | Elan Corporation, Plc | Drug delivery device |
US6200289B1 (en) | 1998-04-10 | 2001-03-13 | Milestone Scientific, Inc. | Pressure/force computer controlled drug delivery system and the like |
US6175752B1 (en) | 1998-04-30 | 2001-01-16 | Therasense, Inc. | Analyte monitoring device and methods of use |
US6321070B1 (en) | 1998-05-14 | 2001-11-20 | Motorola, Inc. | Portable electronic device with a speaker assembly |
DE19822031C2 (en) | 1998-05-15 | 2000-03-23 | Disetronic Licensing Ag | Auto injection device |
DE19821933C1 (en) | 1998-05-15 | 1999-11-11 | Disetronic Licensing Ag | Device for administering an injectable product |
US6219587B1 (en) | 1998-05-27 | 2001-04-17 | Nextrx Corporation | Automated pharmaceutical management and dispensing system |
US6158613A (en) | 1998-06-04 | 2000-12-12 | Voice Based Products, Inc. | Voice based pharmaceutical container apparatus and method for programming |
US5964739A (en) | 1998-06-18 | 1999-10-12 | Champ; Raynido A. | Safety disposable needle structure |
US6428528B2 (en) | 1998-08-11 | 2002-08-06 | Antares Pharma, Inc. | Needle assisted jet injector |
US6074213A (en) | 1998-08-17 | 2000-06-13 | Hon; David C. | Fractional process simulator with remote apparatus for multi-locational training of medical teams |
US6558320B1 (en) | 2000-01-20 | 2003-05-06 | Medtronic Minimed, Inc. | Handheld personal data assistant (PDA) with a medical device and method of using the same |
US6554798B1 (en) | 1998-08-18 | 2003-04-29 | Medtronic Minimed, Inc. | External infusion device with remote programming, bolus estimator and/or vibration alarm capabilities |
GB2341804B (en) | 1998-09-25 | 2003-02-12 | David William Parker | Improvements in or relating to hypodermic syringes |
CA2666429A1 (en) | 1998-10-08 | 2000-04-13 | Medtronic Minimed, Inc. | Telemetered characteristic monitor system |
US6144310A (en) | 1999-01-26 | 2000-11-07 | Morris; Gary Jay | Environmental condition detector with audible alarm and voice identifier |
US6323780B1 (en) | 1998-10-14 | 2001-11-27 | Gary J. Morris | Communicative environmental alarm system with voice indication |
CA2251863A1 (en) | 1998-10-20 | 2000-04-20 | Zoni Inc. | Belt system for housing medical device |
SE9803662D0 (en) | 1998-10-26 | 1998-10-26 | Pharmacia & Upjohn Ab | autoinjector |
US6645181B1 (en) | 1998-11-13 | 2003-11-11 | Elan Pharma International Limited | Drug delivery systems and methods |
US6689093B2 (en) | 1998-11-18 | 2004-02-10 | Bioject, Inc. | Single-use needle-less hypodermic jet injection apparatus and method |
US6096002A (en) | 1998-11-18 | 2000-08-01 | Bioject, Inc. | NGAS powered self-resetting needle-less hypodermic jet injection apparatus and method |
US6783509B1 (en) | 1998-11-18 | 2004-08-31 | Bioject Inc. | Single-use needle-less hypodermic jet injection apparatus and method |
US6264629B1 (en) | 1998-11-18 | 2001-07-24 | Bioject, Inc. | Single-use needle-less hypodermic jet injection apparatus and method |
US6334070B1 (en) | 1998-11-20 | 2001-12-25 | Medtronic Physio-Control Manufacturing Corp. | Visual and aural user interface for an automated external defibrillator |
US20060058848A1 (en) | 1998-11-20 | 2006-03-16 | Medtronic Emergency Response Systems, Inc. | AED with user inputs in response to prompts |
US6540672B1 (en) | 1998-12-09 | 2003-04-01 | Novo Nordisk A/S | Medical system and a method of controlling the system for use by a patient for medical self treatment |
US6312412B1 (en) | 1998-12-02 | 2001-11-06 | V. C. Saied, M.D. | Apparatus and method for painless intramuscular or subcutaneous injections |
US6383168B1 (en) | 1998-12-08 | 2002-05-07 | Bioject Medical Technologies Inc. | Needleless syringe with prefilled cartridge |
US6406455B1 (en) * | 1998-12-18 | 2002-06-18 | Biovalve Technologies, Inc. | Injection devices |
US6364866B1 (en) | 1999-01-22 | 2002-04-02 | Douglas Furr | Syringe loading aid |
US6317630B1 (en) | 1999-01-29 | 2001-11-13 | Yossi Gross | Drug delivery device |
US6872080B2 (en) | 1999-01-29 | 2005-03-29 | Cardiac Science, Inc. | Programmable AED-CPR training device |
DE29904864U1 (en) | 1999-03-17 | 2000-08-03 | Braun Melsungen Ag | Injection device with a pen |
DE19912322A1 (en) | 1999-03-19 | 2000-09-28 | Vetter & Co Apotheker | Syringe for medical purposes |
JP4326704B2 (en) | 1999-04-16 | 2009-09-09 | ベクトン・ディキンソン・アンド・カンパニー | Pen-type syringe with automatic compounding function |
US6190326B1 (en) | 1999-04-23 | 2001-02-20 | Medtrac Technologies, Inc. | Method and apparatus for obtaining patient respiratory data |
US6202642B1 (en) | 1999-04-23 | 2001-03-20 | Medtrac Technologies, Inc. | Electronic monitoring medication apparatus and method |
US6192891B1 (en) | 1999-04-26 | 2001-02-27 | Becton Dickinson And Company | Integrated system including medication delivery pen, blood monitoring device, and lancer |
US6245046B1 (en) | 1999-05-03 | 2001-06-12 | University Of New Mexico | Reciprocating syringes |
US6428517B1 (en) | 1999-05-10 | 2002-08-06 | Milestone Scientific, Inc. | Hand-piece for injection device with a retractable and rotating needle |
SE9901736D0 (en) | 1999-05-12 | 1999-05-12 | Pharmacia & Upjohn Ab | Injectino device and method for ITS operation |
US6084526A (en) | 1999-05-12 | 2000-07-04 | Time Warner Entertainment Co., L.P. | Container with means for displaying still and moving images |
DE19925904C1 (en) * | 1999-06-07 | 2001-02-01 | Disetronic Licensing Ag | Unit for subcutaneous application of an injectable product comprises a system which indicates whether the protection sleeve of the injection needle is in its fully retracted position |
US6398760B1 (en) | 1999-10-01 | 2002-06-04 | Baxter International, Inc. | Volumetric infusion pump with servo valve control |
HU225877B1 (en) | 1999-07-27 | 2007-11-28 | Pharma Consult Gmbh | Device for automatically injecting injection liquids |
EP1200144A1 (en) | 1999-07-30 | 2002-05-02 | Medrad, Inc. | Injector systems and syringe adapters for use therewith |
ATE318157T1 (en) | 1999-08-05 | 2006-03-15 | Becton Dickinson Co | PEN-SHAPED MEDICATION DELIVERY DEVICE |
US6238374B1 (en) | 1999-08-06 | 2001-05-29 | Proxima Therapeutics, Inc. | Hazardous fluid infuser |
US6377848B1 (en) | 1999-08-25 | 2002-04-23 | Vyteris, Inc. | Devices activating an iontophoretic delivery device |
US6102896A (en) | 1999-09-08 | 2000-08-15 | Cambridge Biostability Limited | Disposable injector device |
AU7839900A (en) | 1999-09-29 | 2001-04-30 | Sterling Medivations, Inc. | Reusable medication delivery device |
AU7780700A (en) | 1999-10-01 | 2001-05-10 | Glaxo Group Limited | Remote patient assessment system |
US6413236B1 (en) | 1999-10-08 | 2002-07-02 | Lewis R. Van Dyke | Automatically retractable needle safety syringe |
US6514230B1 (en) | 1999-10-12 | 2003-02-04 | Novo Nordisk A/S | Air shot mechanism for electronic injection devices |
US6569123B2 (en) | 1999-10-14 | 2003-05-27 | Becton, Dickinson And Company | Prefillable intradermal injector |
JP2001112867A (en) * | 1999-10-18 | 2001-04-24 | Terumo Corp | Syringe containing drug |
ES2299439T3 (en) | 1999-10-22 | 2008-06-01 | Antares Pharma, Inc. | MEDICINAL CARTRIDGE AND INJECTION DEVICE. |
US6673035B1 (en) | 1999-10-22 | 2004-01-06 | Antares Pharma, Inc. | Medical injector and medicament loading system for use therewith |
US6585698B1 (en) * | 1999-11-01 | 2003-07-01 | Becton, Dickinson & Company | Electronic medical delivery pen having a multifunction actuator |
PE20010720A1 (en) | 1999-12-11 | 2001-07-26 | Glaxo Group Ltd | MEDICATION DISTRIBUTOR |
WO2001051109A1 (en) | 2000-01-07 | 2001-07-19 | Biovalve Technologies, Inc. | Injection device |
US6193695B1 (en) | 2000-01-14 | 2001-02-27 | Wayland J. Rippstein, Jr. | Disposable safety syringe having a retractable needle |
DE50009584D1 (en) | 2000-01-18 | 2005-03-31 | Zimmer Gmbh Winterthur | Pistol for pressing out bone cement with an attachable cement syringe |
US6210359B1 (en) | 2000-01-21 | 2001-04-03 | Jet Medica, L.L.C. | Needleless syringe |
US6565533B1 (en) | 2000-01-21 | 2003-05-20 | Novus International, Inc. | Inoculation apparatus and method |
GB0002095D0 (en) | 2000-01-28 | 2000-03-22 | Novartis Ag | Device |
DE10006368A1 (en) | 2000-02-12 | 2001-08-16 | Pfeiffer Erich Gmbh & Co Kg | Discharge device for media |
US20030060765A1 (en) | 2000-02-16 | 2003-03-27 | Arthur Campbell | Infusion device menu structure and method of using the same |
US6478769B1 (en) | 2000-02-22 | 2002-11-12 | The Board Of Trustees Of The University Of Arkansas | Anatomical fluid evacuation apparatus and method |
US6321654B1 (en) | 2000-02-22 | 2001-11-27 | The United States Of America As Represented By The Secretary Of The Army | Microelectromechanical systems (MEMS) -type devices having latch release and output mechanisms |
US6485465B2 (en) | 2000-03-29 | 2002-11-26 | Medtronic Minimed, Inc. | Methods, apparatuses, and uses for infusion pump fluid pressure and force detection |
BR0110158A (en) | 2000-04-18 | 2004-12-28 | Mdc Invest Holdings Inc | Medical device, and methods for infusing fluid into a patient with a medical device, for transfusing one of the blood and plasma into and out of a patient with a medical device, and for inserting a guide wire into a patient using a medical device. needle carrier doctor |
JP4891512B2 (en) | 2000-04-26 | 2012-03-07 | ユニトラクト シリンジ プロプライエタリイ リミテッド | Single use syringe |
US6284765B1 (en) | 2000-04-27 | 2001-09-04 | The University Of North Texas Health Science Center At Fort Worth | (+) naloxone and epinephrine combination therapy |
US6607508B2 (en) | 2000-04-27 | 2003-08-19 | Invivotech, Inc. | Vial injector device |
US20040069667A1 (en) * | 2000-05-12 | 2004-04-15 | Tomellini Dalita R. | Cases for medication delivery devices |
AU2001261723B2 (en) | 2000-05-18 | 2007-10-25 | Aesynt Incorporated | Distributed remote asset and medication management drug delivery system |
TW499314B (en) | 2000-05-30 | 2002-08-21 | Novo Nordisk As | A medication delivery device with replaceable cooperating modules and a method of making same |
US20020000225A1 (en) | 2000-06-02 | 2002-01-03 | Carlos Schuler | Lockout mechanism for aerosol drug delivery devices |
WO2001093925A2 (en) | 2000-06-08 | 2001-12-13 | Meridian Medical Technologies, Inc. | Wet/dry automatic injector assembly |
US6517517B1 (en) | 2000-06-08 | 2003-02-11 | Mayo Foundation For Medical Education And Research | Automated injection device for administration of liquid medicament |
US6633796B1 (en) | 2000-06-14 | 2003-10-14 | Dan B. Pool | Medication timing device |
US6663602B2 (en) | 2000-06-16 | 2003-12-16 | Novo Nordisk A/S | Injection device |
US6540675B2 (en) | 2000-06-27 | 2003-04-01 | Rosedale Medical, Inc. | Analyte monitor |
US6535714B2 (en) | 2000-06-30 | 2003-03-18 | University Of Florida | Method, system, and apparatus for medical device training |
US7530964B2 (en) | 2000-06-30 | 2009-05-12 | Elan Pharma International Limited | Needle device and method thereof |
US6961285B2 (en) | 2000-07-07 | 2005-11-01 | Ddms Holdings L.L.C. | Drug delivery management system |
US6411567B1 (en) | 2000-07-07 | 2002-06-25 | Mark A. Niemiec | Drug delivery management system |
BR0112825A (en) | 2000-07-28 | 2003-07-01 | Mdc Invest Holdings Inc | Process for injecting medicine from a medical device that has a needle with a sharp tip and medical device |
US6589229B1 (en) | 2000-07-31 | 2003-07-08 | Becton, Dickinson And Company | Wearable, self-contained drug infusion device |
US6199949B1 (en) * | 2000-07-31 | 2001-03-13 | Dasilva Eric S. | Child safety seat |
US6572584B1 (en) | 2000-08-07 | 2003-06-03 | Retractable Technologies, Inc. | Retractable syringe with reduced retraction force |
DE10038936B4 (en) * | 2000-08-09 | 2009-02-05 | Tecpharma Licensing Ag | Device for dosing substances with continuous speech output |
US6530904B1 (en) | 2000-08-15 | 2003-03-11 | Evan T. Edwards | Medical injector |
AU2001286518A1 (en) | 2000-08-15 | 2002-02-25 | University Of Kentucky Research Foundation | Programmable multi-dose intranasal drug delivery device |
AU2001281753A1 (en) | 2000-08-29 | 2002-03-13 | Novo-Nordisk A/S | Automatic injection device with torsion function for retraction of needle |
US6803856B1 (en) | 2000-09-07 | 2004-10-12 | Hewlett-Packard Development Company, L.P. | Storage apparatus |
AU2001289589A1 (en) * | 2000-09-22 | 2002-04-02 | Novo-Nordisk A/S | A medication delivery device |
IL138766A0 (en) | 2000-09-28 | 2001-10-31 | Cyclo Science Ltd | Constant pressure apparatus for the administration of fluids intravenously |
US6656150B2 (en) | 2000-10-10 | 2003-12-02 | Meridian Medical Technologies, Inc. | Wet/dry automatic injector assembly |
US6770052B2 (en) | 2000-10-10 | 2004-08-03 | Meridian Medical Technologies, Inc. | Wet/dry automatic injector assembly |
US7621887B2 (en) * | 2000-10-10 | 2009-11-24 | Meridian Medical Technologies, Inc. | Wet/dry automatic injector assembly |
EP1339312B1 (en) | 2000-10-10 | 2006-01-04 | Microchips, Inc. | Microchip reservoir devices using wireless transmission of power and data |
US6641561B1 (en) * | 2000-10-10 | 2003-11-04 | Meridian Medical Technologies, Inc. | Drug delivery device |
US6953445B2 (en) | 2000-10-10 | 2005-10-11 | Meridian Medical Technologies, Inc. | Wet/dry automatic injector assembly |
WO2002032287A2 (en) | 2000-10-17 | 2002-04-25 | Schneider Patricia G | Emergency medical dispensing card |
FR2815543B1 (en) | 2000-10-19 | 2003-10-24 | Sedat | SELF-INJECTION SYRINGE OF AN EXTEMPORANEOUS MIXTURE |
FR2815544B1 (en) | 2000-10-23 | 2003-02-14 | Poudres & Explosifs Ste Nale | SAFETY NEEDLE SYRINGE WITH COMPACT ARCHITECTURE |
US6551298B1 (en) | 2000-11-21 | 2003-04-22 | Jack Y. Zhang | Controlled medicament security enclosure system |
EP1339442A4 (en) | 2000-11-30 | 2006-12-27 | Biovalve Technologies Inc | Injection systems |
SE518981C2 (en) | 2000-12-14 | 2002-12-17 | Shl Medical Ab | autoinjector |
US20020076679A1 (en) | 2000-12-19 | 2002-06-20 | Aman Craig S. | Web enabled medical device training |
US6387078B1 (en) | 2000-12-21 | 2002-05-14 | Gillespie, Iii Richard D. | Automatic mixing and injecting apparatus |
IL156245A0 (en) | 2000-12-22 | 2004-01-04 | Dca Design Int Ltd | Drive mechanism for an injection device |
DE10065160A1 (en) * | 2000-12-23 | 2002-06-27 | Pfeiffer Erich Gmbh & Co Kg | Device for detecting the actuation of a dispenser and dispenser |
US6560471B1 (en) | 2001-01-02 | 2003-05-06 | Therasense, Inc. | Analyte monitoring device and methods of use |
WO2002056947A1 (en) | 2001-01-18 | 2002-07-25 | Medrad, Inc. | Syringe interfaces and adapters for use with medical injectors |
WO2002056822A1 (en) | 2001-01-19 | 2002-07-25 | Raimo Juselius | Device for monitoring the administration of doses and system for monitoring the administration of doses |
US6597794B2 (en) | 2001-01-23 | 2003-07-22 | Hewlett-Packard Development Company, L.P. | Portable electronic device having an external speaker chamber |
US6811545B2 (en) | 2001-01-31 | 2004-11-02 | Vincent L. Vaillancourt | Safety needle |
US6707763B2 (en) | 2001-02-02 | 2004-03-16 | Diduminder Corporation | Closure cap including timer and cooperating switch member and associated methods |
US6749437B2 (en) | 2001-02-05 | 2004-06-15 | Thinking Technology, Inc. | Electronic display materials associated with products |
JP2004532670A (en) | 2001-02-22 | 2004-10-28 | インシュレット コーポレイション | Modular infusion device and method |
JP4058498B2 (en) * | 2001-02-23 | 2008-03-12 | ストライカー コーポレイション | Integrated drug delivery system |
GB0108228D0 (en) | 2001-04-02 | 2001-05-23 | Glaxo Group Ltd | Medicament dispenser |
WO2002083205A1 (en) | 2001-04-13 | 2002-10-24 | Becton Dickinson And Company, Inc. | Prefillable intradermal delivery device with hidden needle and passive shielding |
US20050192530A1 (en) | 2001-04-13 | 2005-09-01 | Penjet Corporation | Method and apparatus for needle-less injection with a degassed fluid |
US6613010B2 (en) | 2001-04-13 | 2003-09-02 | Penjet Corporation | Modular gas-pressured needle-less injector |
WO2002083212A1 (en) | 2001-04-13 | 2002-10-24 | Becton Dickinson And Company | Prefillable intradermal injector |
US6817986B2 (en) | 2001-04-13 | 2004-11-16 | Avant Medical Corp. | Jet injector with data logging system for use in compliance and dose monitoring programs |
US6539281B2 (en) | 2001-04-23 | 2003-03-25 | Accenture Global Services Gmbh | Online medicine cabinet |
JP4371660B2 (en) | 2001-04-26 | 2009-11-25 | ニユー・イングランド・フアーマシユーテイカルズ・インコーポレイテツド | Metered dose devices for liquid and powdered drugs |
PT2258424E (en) | 2001-05-16 | 2013-03-28 | Lilly Co Eli | Medication injector apparatus |
ES2498966T3 (en) | 2001-05-21 | 2014-09-26 | Scott Laboratories, Inc. | RF-ID tag for a medical container |
AU2002326304A1 (en) | 2001-05-31 | 2002-12-16 | Massachusetts Institute Of Technology | Microchip devices with improved reservoir opening |
US6752781B2 (en) | 2001-06-08 | 2004-06-22 | Sergio Landau | Durable hypodermic jet injector apparatus and method |
US6585685B2 (en) | 2001-06-08 | 2003-07-01 | Bioject Inc. | Jet injector apparatus and method |
US6648850B2 (en) | 2001-06-08 | 2003-11-18 | Bioject, Inc. | Durable needle-less jet injector apparatus and method |
WO2002100469A2 (en) | 2001-06-11 | 2002-12-19 | Glaxo Group Limited | Medicament dispenser for containers of varying sizes |
US7544188B2 (en) | 2001-07-19 | 2009-06-09 | Intelliject, Inc. | Medical injector |
GB0118419D0 (en) | 2001-07-28 | 2001-09-19 | Owen Mumford Ltd | Improvements relating to injection devices |
US6747556B2 (en) | 2001-07-31 | 2004-06-08 | Medtronic Physio-Control Corp. | Method and system for locating a portable medical device |
JP2004538103A (en) | 2001-08-09 | 2004-12-24 | ベクトン・ディキンソン・アンド・カンパニー | Retractable safety needle device |
GB0119520D0 (en) | 2001-08-10 | 2001-10-03 | Owen Mumford Ltd | Improvements relating to injection devices |
US20080177154A1 (en) | 2001-08-13 | 2008-07-24 | Novo Nordisk A/S | Portable Device and Method Of Communicating Medical Data Information |
US20030065536A1 (en) | 2001-08-13 | 2003-04-03 | Hansen Henrik Egesborg | Portable device and method of communicating medical data information |
DE10140704A1 (en) | 2001-08-18 | 2003-03-06 | Vetter & Co Apotheker | Process for mixing a poorly soluble pharmaceutical substance with a solvent and syringe to apply the process |
JP2003070909A (en) | 2001-08-30 | 2003-03-11 | Japan Servo Co Ltd | Transfusion device |
US6722916B2 (en) | 2001-08-30 | 2004-04-20 | Siemens Vdo Automotive Corporation | Surface battery clip |
DE60236011D1 (en) | 2001-09-06 | 2010-05-27 | Microdose Therapeutx Inc | Inhaler type DPI |
US6875195B2 (en) | 2001-09-19 | 2005-04-05 | Soo Bong Choi | Portable automatic insulin syringe device with blood sugar measuring function |
US6723077B2 (en) | 2001-09-28 | 2004-04-20 | Hewlett-Packard Development Company, L.P. | Cutaneous administration system |
WO2003030974A1 (en) * | 2001-10-08 | 2003-04-17 | Eli Lilly And Company | Portable medication inhalation kit |
US6494863B1 (en) | 2001-10-15 | 2002-12-17 | Retractable Technologies, Inc. | One-use retracting syringe with positive needle retention |
GB0125506D0 (en) | 2001-10-24 | 2001-12-12 | Weston Medical Ltd | Needle free injection method and apparatus |
US7569035B1 (en) | 2001-11-02 | 2009-08-04 | Meridian Medical Technologies, Inc. | Automatic injector with anti-coring needle |
KR20050042210A (en) | 2001-11-02 | 2005-05-06 | 메리디안 메디칼 테크놀로지즈 인코포레이티드 | A medicament container, a medicament dispensing kit for administering medication and a method for packaging the same |
SI2221076T1 (en) | 2001-11-09 | 2013-06-28 | Alza Corporation | Pneumatic powered autoinjector |
US6736796B2 (en) | 2001-11-26 | 2004-05-18 | Nili-Med Ltd. | Fluid drug delivery device |
US20030105430A1 (en) * | 2001-11-30 | 2003-06-05 | Elan Pharma International Limited Wil House | Automatic injector |
EP1462134A4 (en) | 2001-12-13 | 2010-03-31 | Panasonic Corp | Administration instrument for medical use |
US6952604B2 (en) | 2001-12-21 | 2005-10-04 | Becton, Dickinson And Company | Minimally-invasive system and method for monitoring analyte levels |
US20030120324A1 (en) | 2001-12-26 | 2003-06-26 | Osborn Brett A. | System and method for remote programming of a medical device |
CA2366887C (en) | 2001-12-31 | 2011-11-01 | Michael Petersen | Replicate incorporating an electronic content monitoring system for use in form-fill-seal applications |
GB0200444D0 (en) | 2002-01-10 | 2002-02-27 | Owen Mumford Ltd | Improvements relating to medical injection devices |
US6985870B2 (en) | 2002-01-11 | 2006-01-10 | Baxter International Inc. | Medication delivery system |
US20030132128A1 (en) | 2002-01-11 | 2003-07-17 | Mazur David P. | Container for syringe |
GB0200637D0 (en) | 2002-01-12 | 2002-02-27 | Dca Design Int Ltd | Improvements in and relating to medicament injection apparatus |
DE60323729D1 (en) | 2002-02-11 | 2008-11-06 | Antares Pharma Inc | INTRADERMAL INJECTION DEVICE |
ES2563981T3 (en) | 2002-02-22 | 2016-03-17 | Gw Pharma Limited | Dose delivery system and apparatus |
US6708050B2 (en) | 2002-03-28 | 2004-03-16 | 3M Innovative Properties Company | Wireless electrode having activatable power cell |
US7014470B2 (en) | 2002-04-16 | 2006-03-21 | High Plains Marketing | Risk Reduction teaching modules |
US7229458B2 (en) | 2002-04-19 | 2007-06-12 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US6946299B2 (en) | 2002-04-25 | 2005-09-20 | Home Diagnostics, Inc. | Systems and methods for blood glucose sensing |
US6743635B2 (en) | 2002-04-25 | 2004-06-01 | Home Diagnostics, Inc. | System and methods for blood glucose sensing |
GB0210631D0 (en) | 2002-05-09 | 2002-06-19 | Glaxo Group Ltd | Novel device |
US20030215455A1 (en) | 2002-05-14 | 2003-11-20 | Bailey Reynolds | Vaccine stabilizer and method of use |
GB0211294D0 (en) | 2002-05-17 | 2002-06-26 | Owen Mumford Ltd | Improvements relating to injection devices |
US6979316B1 (en) * | 2002-05-23 | 2005-12-27 | Seedlings Life Science Ventures Llc | Apparatus and method for rapid auto-injection of medication |
EP3292821A1 (en) | 2002-05-31 | 2018-03-14 | Vidacare LLC | Apparatus and method to access bone marrow |
EP1369139A1 (en) | 2002-06-03 | 2003-12-10 | 3M Innovative Properties Company | Dose indicators and dispensing canister-indicator assemblies |
US6676630B2 (en) | 2002-06-04 | 2004-01-13 | Bioject Medical Technologies, Inc. | Needle-free injection system |
RU2209166C1 (en) | 2002-06-07 | 2003-07-27 | ООО "Марс" | Package with sound reproduction |
EP1404494B1 (en) | 2002-06-17 | 2004-10-06 | Matsushita Electric Works, Ltd. | Dry shaver with a trimmer |
TWI314464B (en) | 2002-06-24 | 2009-09-11 | Alza Corp | Reusable, spring driven autoinjector |
WO2004000392A1 (en) | 2002-06-25 | 2003-12-31 | Medrad, Inc. | Devices, systems and methods for injecting multiple fluids into a patient |
DE60335108D1 (en) | 2002-07-02 | 2011-01-05 | Panasonic Corp | |
AU2003239785A1 (en) | 2002-07-10 | 2004-02-02 | Novo Nordisk A/S | An injection device with a dose setting limiter |
US6945961B2 (en) | 2002-07-10 | 2005-09-20 | Novo Nordisk A/S | Injection device |
US7278983B2 (en) | 2002-07-24 | 2007-10-09 | Medtronic Minimed, Inc. | Physiological monitoring device for controlling a medication infusion device |
AU2003257994A1 (en) | 2002-07-31 | 2004-02-16 | Alza Corporation | Injection device providing automatic needle retraction |
US6929619B2 (en) | 2002-08-02 | 2005-08-16 | Liebel-Flarshiem Company | Injector |
US6764469B2 (en) | 2002-08-02 | 2004-07-20 | Broselow James B | Color-coded medical dosing container |
US20040039337A1 (en) | 2002-08-21 | 2004-02-26 | Letzing Michael Alexander | Portable safety auto-injector |
US7699052B2 (en) | 2002-09-05 | 2010-04-20 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Apparatus for the dispensing of liquids, container cartridge suitable for this, and system comprising the apparatus for the dispensing of liquids, and the container cartridge |
JP2005537907A (en) | 2002-09-06 | 2005-12-15 | マサチューセッツ・インスティテュート・オブ・テクノロジー | Biological property measuring apparatus and method |
CN1723053A (en) | 2002-09-12 | 2006-01-18 | 儿童医院医疗中心 | Method and device for painless injection of medication |
FR2845016B1 (en) | 2002-09-27 | 2004-12-03 | Becton Dickinson France | SPRAYING OR INJECTION DEVICE FOR DELIVERING AT LEAST TWO SPECIFIED DOSES OF PRODUCT |
US6883222B2 (en) | 2002-10-16 | 2005-04-26 | Bioject Inc. | Drug cartridge assembly and method of manufacture |
GB0224505D0 (en) | 2002-10-22 | 2002-11-27 | Medical House The Plc | Needles injection device |
JP2006504476A (en) * | 2002-11-05 | 2006-02-09 | エム2・メディカル・アクティーゼルスカブ | Disposable, wearable insulin administration device, combination of the device and program control device, and operation control method of the device |
US6800070B2 (en) | 2002-11-07 | 2004-10-05 | George Mazidji | Lockable tranquilizer bracelet |
US20040147818A1 (en) | 2002-11-18 | 2004-07-29 | Andrew Levy | Portable system for monitoring and processing patient parameters in multiple oprational modes |
DE60232750D1 (en) | 2002-11-18 | 2009-08-06 | Sergio Restelli | PROTECTION DEVICE FIXABLE TO A STANDARD SPRAY TO CHANGE IT TO A SAFETY POINT |
EP1572271A1 (en) | 2002-11-25 | 2005-09-14 | Tecpharma Licensing AG | Auto-injector comprising a resettable releasing safety device |
WO2004047892A1 (en) | 2002-11-25 | 2004-06-10 | Tecpharma Licensing Ag | Injection apparatus comprising a needle-protecting device |
CH695926A5 (en) | 2002-11-25 | 2006-10-31 | Tecpharma Licensing Ag | Device for automatically injecting an active ingredient. |
EP1572268A1 (en) | 2002-11-25 | 2005-09-14 | Tecpharma Licensing AG | Device for automatically injecting an active agent |
US20040116854A1 (en) | 2002-12-12 | 2004-06-17 | Abulhaj Ramzi F. | Syringe retractable needle and method |
GB0229345D0 (en) * | 2002-12-17 | 2003-01-22 | Safe T Ltd | Hollow needle applicators |
CN1738656A (en) | 2002-12-23 | 2006-02-22 | M2医药有限公司 | Disposable, wearable insulin dispensing device, a combination of such a device and a programming controller and a method of controlling the operation of such a device |
US6767336B1 (en) | 2003-01-09 | 2004-07-27 | Sheldon Kaplan | Automatic injector |
US7158011B2 (en) | 2003-02-14 | 2007-01-02 | Brue Vesta L | Medication compliance device |
US7329241B2 (en) | 2003-02-14 | 2008-02-12 | Valeant Pharmaceuticals North America | Drug delivery system for administering an adjustable preset dose |
US6935384B2 (en) | 2003-02-19 | 2005-08-30 | Bioject Inc. | Needle-free injection system |
GB0304822D0 (en) | 2003-03-03 | 2003-04-09 | Dca Internat Ltd | Improvements in and relating to a pen-type injector |
US6814265B2 (en) | 2003-03-06 | 2004-11-09 | Alcon, Inc. | Device for dispensing fluid medicine |
US7126879B2 (en) | 2003-03-10 | 2006-10-24 | Healthtrac Systems, Inc. | Medication package and method |
WO2004082747A1 (en) | 2003-03-20 | 2004-09-30 | Unitract Syringe Pty Ltd | Syringe spring retainer |
FR2852851B1 (en) | 2003-03-25 | 2006-01-06 | Sedat | NEEDLE PROTECTION DEVICE FOR SYRINGE, AND INJECTION DEVICE COMPRISING SYRINGE AND PROTECTIVE DEVICE |
GB0308267D0 (en) | 2003-04-10 | 2003-05-14 | Dca Design Int Ltd | Improvements in and relating to a pen-type injector |
US7534107B2 (en) | 2003-04-14 | 2009-05-19 | The General Hospital Corporation | Inoculation training kit |
US7281502B2 (en) * | 2003-04-24 | 2007-10-16 | Team Holdings (Uk) Limited | Powered devices |
JP4443957B2 (en) | 2003-04-28 | 2010-03-31 | 株式会社根本杏林堂 | Leak detection device and method |
US7351223B2 (en) | 2003-05-05 | 2008-04-01 | Physicians Industries, Inc. | Infusion syringe with integrated pressure transducer |
US6805686B1 (en) | 2003-05-06 | 2004-10-19 | Abbott Laboratories | Autoinjector with extendable needle protector shroud |
DE10323603A1 (en) | 2003-05-20 | 2004-12-30 | Ing. Erich Pfeiffer Gmbh | Dosing device with a pump device |
US7824373B2 (en) | 2003-05-28 | 2010-11-02 | Ducksoo Kim | Self-contained power-assisted syringe |
US20070100288A1 (en) | 2003-06-05 | 2007-05-03 | University Of Florida Research Foundation, Inc. | Auto-injection devices and methods for intramuscular administration of medications |
US6963280B2 (en) | 2003-06-16 | 2005-11-08 | Honeywell International Inc. | Door security device for use in security systems |
US20040267204A1 (en) | 2003-06-26 | 2004-12-30 | Brustowicz Robert M. | On-demand needle retaining and locking mechanism for use in intravenous catheter assemblies |
US7500963B2 (en) | 2003-07-22 | 2009-03-10 | Safety Syringes, Inc. | Systems and methods for automatic medical injection with safeguard |
JP2005045504A (en) * | 2003-07-28 | 2005-02-17 | Toshiba Corp | Multi-carrier communication system, multi-carrier receiving device, and multi-carrier transmitting device |
US20050027255A1 (en) | 2003-07-31 | 2005-02-03 | Sid Technologies, Llc | Automatic injector |
US20050055014A1 (en) | 2003-08-04 | 2005-03-10 | Coppeta Jonathan R. | Methods for accelerated release of material from a reservoir device |
US20050062603A1 (en) | 2003-08-06 | 2005-03-24 | Oren Fuerst | Secure, networked and wireless access, storage and retrival system and method utilizing tags and modular nodes |
US20060247578A1 (en) | 2003-08-11 | 2006-11-02 | Andrew Arguedas | Powered automatic injection device |
DE10339794A1 (en) | 2003-08-28 | 2005-04-07 | Tecpharma Licensing Ag | Administering device with a protective cap removal device and a needle protection sleeve blocking device |
AT7347U1 (en) | 2003-08-29 | 2005-02-25 | Pharma Consult Ges M B H & Co | DEVICE FOR THE AUTOMATIC INJECTION OF INJECTION LIQUIDS |
IL157981A (en) | 2003-09-17 | 2014-01-30 | Elcam Medical Agricultural Cooperative Ass Ltd | Auto-injector |
US7490021B2 (en) | 2003-10-07 | 2009-02-10 | Hospira, Inc. | Method for adjusting pump screen brightness |
US8065161B2 (en) | 2003-11-13 | 2011-11-22 | Hospira, Inc. | System for maintaining drug information and communicating with medication delivery devices |
US20050088289A1 (en) | 2003-10-10 | 2005-04-28 | Marc Rochkind | Split-responsibility medication reminder system, and associated methods |
US20050148931A1 (en) | 2003-10-30 | 2005-07-07 | Juhasz Paul R. | Safety syringe |
US6884232B1 (en) * | 2003-10-31 | 2005-04-26 | Baxter International Inc. | Laparoscopic spray device and method of use |
JP4704351B2 (en) | 2003-11-06 | 2011-06-15 | ライフスキャン・インコーポレイテッド | Drug introduction pen with event notification means |
US7699807B2 (en) | 2003-11-10 | 2010-04-20 | Smiths Medical Asd, Inc. | Device and method for insertion of a cannula of an infusion device |
US7494481B2 (en) | 2004-12-03 | 2009-02-24 | Medtronic Minimed, Inc. | Multi-position infusion set device and process |
WO2005058385A2 (en) | 2003-12-12 | 2005-06-30 | Philometron, Inc. | Multiple section parenteral drug delivery apparatus |
US7256682B2 (en) | 2003-12-18 | 2007-08-14 | Odin Technologies, Inc. | Remote identification of container contents by means of multiple radio frequency identification systems |
CH696421A5 (en) | 2003-12-18 | 2007-06-15 | Tecpharma Licensing Ag | Autoinjector with arresting the drug container. |
US20050148945A1 (en) | 2003-12-24 | 2005-07-07 | Chen Yong S. | Medical syringe |
US7604613B2 (en) | 2004-01-20 | 2009-10-20 | Beckton, Dickinson And Company | Syringe having a retractable needle |
DK1715903T3 (en) | 2004-01-23 | 2008-02-25 | Medical House Plc | injecting |
GB2410188B (en) | 2004-01-23 | 2006-01-25 | Medical House Plc | Injection device |
US8002745B2 (en) | 2004-01-28 | 2011-08-23 | Unitract Syringe Pty Ltd. | Retractable syringe with plunger disabling system |
US20050168337A1 (en) | 2004-01-30 | 2005-08-04 | Mahoney Jerome R. | Wirelessly loaded speaking medicine container |
TWI244303B (en) | 2004-02-03 | 2005-11-21 | Benq Corp | Resonation chambers within a cell phone |
GB0403335D0 (en) | 2004-02-14 | 2004-03-17 | Liversidge Barry P | Medical injector handling device |
US7670314B2 (en) | 2004-02-17 | 2010-03-02 | Children's Hospital Medical Center | Injection device for administering a vaccine |
SI1715904T1 (en) | 2004-02-18 | 2016-01-29 | Ares Trading S.A. | Hand-held electronically controlled injection device for injecting liquid medications |
DE102004009918B4 (en) | 2004-02-20 | 2007-03-01 | Schott Ag | Arrangement for storing, transporting and applying a preferably medical liquid |
US7263947B2 (en) | 2004-02-24 | 2007-09-04 | Harry Giewercer | Extended use reminder device |
WO2005083947A1 (en) | 2004-02-26 | 2005-09-09 | Novo Nordisk A/S | A method and a system for safe pairing of wireless communication devices |
US20050222539A1 (en) | 2004-03-30 | 2005-10-06 | Pediamed Pharmaceuticals, Inc. | Automatic injection device |
PL1732627T3 (en) | 2004-03-31 | 2010-09-30 | Lilly Co Eli | Injection apparatus having a needle cassette for delivering a pharmaceutical liquid |
WO2005110387A2 (en) * | 2004-04-30 | 2005-11-24 | Becton, Dickinson And Company | Systems and methods for administering a medical regimen |
US7465294B1 (en) | 2004-05-19 | 2008-12-16 | Roman Vladimirsky | Retractable hypodermic needle |
GB2414404B (en) | 2004-05-28 | 2009-06-03 | Cilag Ag Int | Injection device |
US7717874B2 (en) | 2004-05-28 | 2010-05-18 | Bioject, Inc. | Needle-free injection system |
GB0414054D0 (en) | 2004-06-23 | 2004-07-28 | Owen Mumford Ltd | Improvements relating to automatic injection devices |
US20080132852A1 (en) | 2004-07-28 | 2008-06-05 | Kleyhan Gennady I | Dosage device |
JP4615926B2 (en) | 2004-07-30 | 2011-01-19 | テルモ株式会社 | Wireless automatic recognition device (RFID) and automatic medicine recognition system |
US20060022806A1 (en) * | 2004-08-02 | 2006-02-02 | Auerbach David M | Medicament container |
US7449012B2 (en) | 2004-08-06 | 2008-11-11 | Meridian Medical Technologies, Inc. | Automatic injector |
FR2874505B1 (en) | 2004-08-27 | 2007-06-08 | Sedat Sa | INJECTION DEVICE COMPRISING A SYRINGE |
US20060074519A1 (en) | 2004-08-27 | 2006-04-06 | Barker Kenneth N | Medication accuracy comparison system |
DE102004042581B4 (en) | 2004-09-02 | 2022-09-15 | Ypsomed Ag | Auto-Pen for dual-chamber ampoule |
PL1786496T3 (en) | 2004-09-03 | 2015-07-31 | L O M Laboratories Inc | Gas-actuated retractable syringe |
US20060069350A1 (en) | 2004-09-30 | 2006-03-30 | Buenger David R | Medical syringe injector pen |
EP1827537B1 (en) | 2004-10-21 | 2019-08-14 | Novo Nordisk A/S | Medication delivery system with a detector for providing a signal indicative of an amount of an ejected dose of drug |
ATE452671T1 (en) | 2004-10-21 | 2010-01-15 | Novo Nordisk As | INJECTION DEVICE HAVING A PROCESSOR FOR COLLECTING EXHAUST INFORMATION |
US8150509B2 (en) | 2004-10-21 | 2012-04-03 | Cardiac Pacemakers, Inc. | Systems and methods for drug therapy enhancement using expected pharmacodynamic models |
EP1814616A1 (en) | 2004-11-04 | 2007-08-08 | Sid Technologies Llc | Automatic injector |
CA2891057C (en) | 2004-11-22 | 2018-11-13 | Kaleo, Inc. | Medicament delivery apparatus and movable indicator |
US10737028B2 (en) | 2004-11-22 | 2020-08-11 | Kaleo, Inc. | Devices, systems and methods for medicament delivery |
US11590286B2 (en) | 2004-11-22 | 2023-02-28 | Kaleo, Inc. | Devices, systems and methods for medicament delivery |
US7648483B2 (en) | 2004-11-22 | 2010-01-19 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
US7947017B2 (en) | 2004-11-22 | 2011-05-24 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
US7648482B2 (en) | 2004-11-22 | 2010-01-19 | Intelliject, Inc. | Devices, systems, and methods for medicament delivery |
AU2004231230A1 (en) | 2004-11-23 | 2006-06-08 | Anbil, Llc | Powered automatic injection device |
WO2006058061A1 (en) | 2004-11-24 | 2006-06-01 | Becton Dickinson And Company | Automatic reconstitution injector device |
US20060116639A1 (en) | 2004-11-29 | 2006-06-01 | Russell Claudia J | Total patient input monitoring |
WO2006058426A1 (en) | 2004-12-01 | 2006-06-08 | Wlt Distributors Inc. | Needle-free injector |
JP4588072B2 (en) | 2004-12-09 | 2010-11-24 | ウェスト ファーマシューティカル サービシズ インコーポレイテッド | Coupling for automatic injection equipment |
US7434686B2 (en) | 2004-12-10 | 2008-10-14 | Michael Prindle | Auto-injector storage and dispensing system |
WO2006069778A2 (en) | 2004-12-29 | 2006-07-06 | Novo Nordisk A/S | Medication delivery device with reminder unit |
JP5216328B2 (en) | 2005-01-24 | 2013-06-19 | アンタレス ファーマ インコーポレイテッド | Pre-filled needle assist syringe jet injector |
US7731686B2 (en) | 2005-02-01 | 2010-06-08 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
US8361026B2 (en) | 2005-02-01 | 2013-01-29 | Intelliject, Inc. | Apparatus and methods for self-administration of vaccines and other medicaments |
US8206360B2 (en) | 2005-02-01 | 2012-06-26 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
US8231573B2 (en) | 2005-02-01 | 2012-07-31 | Intelliject, Inc. | Medicament delivery device having an electronic circuit system |
US9022980B2 (en) | 2005-02-01 | 2015-05-05 | Kaleo, Inc. | Medical injector simulation device |
JP4948422B2 (en) | 2005-02-01 | 2012-06-06 | インテリジェクト,インコーポレイテッド | Drug delivery apparatus, system and method |
EP1690560A1 (en) | 2005-02-14 | 2006-08-16 | Ares Trading S.A. | Medication delivery device |
EP1690559A1 (en) | 2005-02-14 | 2006-08-16 | Ares Trading S.A. | Medication delivery device |
DE102005007614A1 (en) | 2005-02-18 | 2006-08-24 | Tecpharma Licensing Ag | Auto-injector with a release lock |
US7686788B2 (en) | 2005-03-03 | 2010-03-30 | Boston Scientific Scimed, Inc. | Catheter having a distal drug delivery unit and method of using same |
US7261559B2 (en) | 2005-04-01 | 2007-08-28 | Ultradent Products, Inc. | Syringe delivery system for dispensing a dental composite or other highly viscous material |
EP1870121A1 (en) | 2005-04-11 | 2007-12-26 | Nemoto Kyorindo Co., Ltd. | Medical liquid injection system |
US7390319B2 (en) | 2005-04-13 | 2008-06-24 | Steven Friedman | Automatic needle injector having safety triggering mechanism |
US8167837B2 (en) | 2005-04-15 | 2012-05-01 | Unitract Syringe Pty Ltd. | Controlled retraction syringe and plunger therefor |
US8114050B2 (en) | 2005-05-12 | 2012-02-14 | Unitract Syringe Pty Ltd | Controlled retraction syringe and plunger therefor |
NZ540250A (en) | 2005-05-20 | 2008-04-30 | Nexus6 Ltd | Reminder alarm for inhaler with variable and selectable ring tone alarms |
WO2006125692A1 (en) | 2005-05-26 | 2006-11-30 | Novo Nordisk A/S | A dosing operation in a medical device |
US20090143761A1 (en) | 2005-06-03 | 2009-06-04 | Transdermal Patents Company, Llc | Agent delivery system and uses of same |
MX2007015229A (en) * | 2005-06-08 | 2008-04-21 | Powercast Corp | Powering devices using rf energy harvesting. |
US9457147B2 (en) | 2005-06-16 | 2016-10-04 | Novo Nordisk A/S | Method and apparatus for assisting patients in self-administration of medication |
US7782189B2 (en) | 2005-06-20 | 2010-08-24 | Carestream Health, Inc. | System to monitor the ingestion of medicines |
US20070074722A1 (en) | 2005-09-21 | 2007-04-05 | Kurve Technology, Inc. | Medicament delivery control, monitoring, and reporting system and method |
DE202005014958U1 (en) | 2005-09-22 | 2005-12-08 | Dieter Hölzle Technik-Projekte GmbH | Injection unit comprising a seat for a syringe body with two pistons and two chambers and a means for driving the plunger to produce a mixing stroke before an injection stroke |
US7611495B1 (en) | 2005-10-07 | 2009-11-03 | Gianturco Michael C | Device for manually controlling delivery rate of a hypodermic syringe and syringe having same |
US7682155B2 (en) | 2005-11-03 | 2010-03-23 | Meridian Medical Technologies, Inc. | Training device for an automatic injector |
DE102005052460A1 (en) | 2005-11-03 | 2007-05-16 | Tecpharma Licensing Ag | Autoinjector - Flow control for container change |
US8992511B2 (en) | 2005-11-09 | 2015-03-31 | The Invention Science Fund I, Llc | Acoustically controlled substance delivery device |
US7988675B2 (en) | 2005-12-08 | 2011-08-02 | West Pharmaceutical Services Of Delaware, Inc. | Automatic injection and retraction devices for use with pre-filled syringe cartridges |
GB2433032A (en) | 2005-12-08 | 2007-06-13 | Owen Mumford Ltd | Syringe with dose adjustment means |
WO2007075839A2 (en) | 2005-12-19 | 2007-07-05 | Diobex, Inc. | Glucagon injector for emergency treatment of hypoglycemia |
US8357114B2 (en) | 2006-01-06 | 2013-01-22 | Acelrx Pharmaceuticals, Inc. | Drug dispensing device with flexible push rod |
GB0601309D0 (en) | 2006-01-23 | 2006-03-01 | Medical House The Plc | Injection device |
US7514172B2 (en) | 2006-01-25 | 2009-04-07 | Eveready Battery Company, Inc. | Battery controlled device that can operate with alternative size batteries |
EA012864B1 (en) | 2006-01-31 | 2009-12-30 | Арес Трейдинг С.А. | Injection device with a capacitive proximity sensor |
TW200744568A (en) | 2006-02-28 | 2007-12-16 | Verus Pharmaceuticals Inc | Epinephrine dosing regimens |
US20090005735A1 (en) | 2006-03-03 | 2009-01-01 | Shl Group Ab | Medical Device with Orientation Sensitive Priming Mechanism |
US20070210147A1 (en) | 2006-03-09 | 2007-09-13 | Jack Morrone | Pocket-size talking card or pamphlet device and packages containing the same |
US20070239140A1 (en) | 2006-03-22 | 2007-10-11 | Revascular Therapeutics Inc. | Controller system for crossing vascular occlusions |
AT502791B1 (en) | 2006-04-06 | 2007-05-15 | Pharma Consult Ges M B H & Co | Injection syringe, has plastic needle holder enclosing stainless steel injection needle, where holder receives injection solution in relation to interior of cylinder and is sealed off by sealing insert, by which rear end of needle protrudes |
US8535286B2 (en) * | 2006-05-02 | 2013-09-17 | Marlafin Ag | Vibrating tampon apparatus with remote control |
US8251947B2 (en) | 2006-05-03 | 2012-08-28 | Antares Pharma, Inc. | Two-stage reconstituting injector |
US7796038B2 (en) | 2006-06-12 | 2010-09-14 | Intelleflex Corporation | RFID sensor tag with manual modes and functions |
NZ572765A (en) | 2006-06-30 | 2012-08-31 | Abbott Biotech Ltd | Automatic injection device with rod driving syringe longitudinally split with radially compressible pair of wings along its length |
ITMO20060222A1 (en) | 2006-07-10 | 2008-01-11 | Alfio Bertolini | ANTIEMORRAGIC MEDICATION PACKAGE |
US8044778B2 (en) | 2007-07-12 | 2011-10-25 | Henry Schein, Inc. | Injection device and case with reporting ability |
US7752085B2 (en) | 2006-07-13 | 2010-07-06 | Henry Schein, Inc. | Product information management system |
US20080160492A1 (en) | 2006-08-08 | 2008-07-03 | Insulet Corporation | Interactive training system and method |
PL2056903T3 (en) * | 2006-08-31 | 2019-04-30 | Meridian Medical Tech Inc | Vortex feature for drug delivery system |
US7772986B2 (en) * | 2006-09-18 | 2010-08-10 | Vesstech, Inc. | Verbal warning systems and other audible warning systems for use with various types of devices, containers, products and other things |
US7976506B2 (en) | 2006-09-29 | 2011-07-12 | Arrow International, Inc. | Syringe with selectable indicia of contents |
US20080234625A1 (en) | 2006-10-16 | 2008-09-25 | Bruno Dacquay | Fuse Assembly For Single Use Medical Device |
US20090124996A1 (en) | 2006-11-03 | 2009-05-14 | Scott Heneveld | Apparatus and methods for injecting high viscosity dermal fillers |
EP1923083A1 (en) | 2006-11-17 | 2008-05-21 | Sanofi-Aventis Deutschland GmbH | Drive mechanisms for use in drug delivery devices |
ATE514443T1 (en) | 2006-12-13 | 2011-07-15 | Shl Group Ab | AUTOINJECTOR |
GB0625169D0 (en) | 2006-12-18 | 2007-01-24 | Medical House Plc The | Improved autoinjector |
US20100169111A1 (en) | 2006-12-22 | 2010-07-01 | Vesta Dauber Brue | Portable Health & Safety Monitoring Device |
WO2008083209A2 (en) | 2006-12-29 | 2008-07-10 | Amir Genosar | Hypodermic drug delivery reservoir and apparatus |
US8276583B2 (en) | 2007-01-17 | 2012-10-02 | Shl Group Ab | Device for delivering medicament |
WO2008091838A2 (en) | 2007-01-22 | 2008-07-31 | Intelliject, Inc. | Medical injector with compliance tracking and monitoring |
CN101641125B (en) | 2007-03-09 | 2013-06-19 | 伊莱利利公司 | Delay mechanism for automatic injection device |
CN101674857A (en) | 2007-03-22 | 2010-03-17 | 特克法马许可公司 | Injection device having trigger safety devices |
DE102007013838A1 (en) | 2007-03-22 | 2008-09-25 | Tecpharma Licensing Ag | Injection device with time-constant Ausschüttsignal |
US8087345B2 (en) | 2007-04-27 | 2012-01-03 | Checkpoint Fluidic Systems International, Ltd. | Positive displacement injection pump |
US20180158374A1 (en) | 2007-05-21 | 2018-06-07 | Jc3 Innovations, Llc | Medical device and procedure simulation and training |
DE102007026560A1 (en) | 2007-06-08 | 2009-01-15 | Tecpharma Licensing Ag | Delivery device with axially movable indicator |
US20090030285A1 (en) | 2007-07-25 | 2009-01-29 | Andersen Bjorn K | Monitoring of use status and automatic power management in medical devices |
NO2180844T3 (en) | 2007-08-02 | 2018-07-21 | ||
EP2190506B1 (en) | 2007-08-17 | 2011-08-17 | Novo Nordisk A/S | Medical device with value sensor |
US20090062730A1 (en) | 2007-09-01 | 2009-03-05 | San Hoon Woo | Control of body fluid condition using diuretics, based on biological parameters |
US7875022B2 (en) * | 2007-12-12 | 2011-01-25 | Asante Solutions, Inc. | Portable infusion pump and media player |
SI2224982T1 (en) | 2007-12-19 | 2013-11-29 | Sanofi-Aventis Deutschland Gmbh | Dual-chamber injection device having gas-permeable membrane |
WO2009095735A1 (en) | 2008-01-30 | 2009-08-06 | Becton Dickinson France | Dose dividing delivery device |
US9550031B2 (en) | 2008-02-01 | 2017-01-24 | Reciprocal Labs Corporation | Device and method to monitor, track, map, and analyze usage of metered-dose inhalers in real-time |
AT505616B1 (en) | 2008-02-07 | 2009-03-15 | Pickhard Brigitte | INJECTION sYRINGE |
US8021344B2 (en) | 2008-07-28 | 2011-09-20 | Intelliject, Inc. | Medicament delivery device configured to produce an audible output |
US8177749B2 (en) | 2008-05-20 | 2012-05-15 | Avant Medical Corp. | Cassette for a hidden injection needle |
DK2296732T3 (en) | 2008-06-11 | 2014-04-07 | Shl Group Ab | DRUG DELIVERY DEVICES |
US8048029B2 (en) | 2008-06-20 | 2011-11-01 | West Pharmaceutical Services, Inc. | Injector apparatus |
GB2462811B (en) | 2008-08-18 | 2012-08-15 | Medical House Ltd | Improved autoinjector |
US8556862B2 (en) | 2008-09-18 | 2013-10-15 | Becton Dickinson And Company | Needle mounting feature for ensuring proper reconstitution sequence |
WO2010037828A1 (en) | 2008-10-01 | 2010-04-08 | Novo Nordisk A/S | Medical assembly with monitoring device |
EP2180459A1 (en) | 2008-10-24 | 2010-04-28 | Sanofi-Aventis Deutschland GmbH | Device for simulating the operation of a medication delivery device |
CA2745936A1 (en) | 2008-12-11 | 2010-06-17 | Sanofi-Aventis Deutschland Gmbh | Medication delivery device |
EP2201973A1 (en) | 2008-12-23 | 2010-06-30 | Sanofi-Aventis Deutschland GmbH | Drug delivery device with piston rod carrying dose markings |
NZ574666A (en) | 2009-02-05 | 2009-04-30 | Nexus6 Ltd | A medicament inhaler holder that uses optical means to count and display the number of doses used |
WO2010089310A1 (en) | 2009-02-05 | 2010-08-12 | Sanofi-Aventis Deutschland Gmbh | Medicament delivery devices |
CN102413856B (en) | 2009-02-27 | 2017-02-08 | 生命扫描有限公司 | Drug delivery system |
DE202009003009U1 (en) | 2009-03-03 | 2009-06-25 | Dieter Hölzle Technik-Projekte GmbH | Injection device with injection volume adjustment |
NZ575836A (en) | 2009-03-27 | 2009-08-28 | Nexus6 Ltd | Improvements in or Relating to Medicament Delivery Systems |
NZ575943A (en) | 2009-04-01 | 2009-07-31 | Nexus6 Ltd | Improvements in or Relating to Medicament Delivery Devices |
US9227009B2 (en) | 2009-04-30 | 2016-01-05 | Sanofi-Aventis Deutschland Gmbh | Pen-type injector with ergonomic button arrangement |
TWI519330B (en) | 2009-06-02 | 2016-02-01 | 賽諾菲阿凡提斯德意志有限公司 | Medicated module with user selection |
AR076721A1 (en) | 2009-06-02 | 2011-06-29 | Sanofi Aventis Deutschland | MEDICINAL MODULE WITH INTEGRAL FLOW DISTRIBUTION SYSTEM |
AR076624A1 (en) | 2009-06-02 | 2011-06-22 | Sanofi Aventis Deutschland | SUPPLY OF TWO OR MORE MEDICINES THROUGH A SINGLE DOSE SELECTION AND A SINGLE DISPENSATION INTERFACE |
AR076719A1 (en) | 2009-06-02 | 2011-06-29 | Sanofi Aventis Deutschland | MEDICINAL MODULE WITH DERIVATION AND NEEDLE PROTECTOR |
CN102458521B (en) | 2009-06-04 | 2014-06-04 | 诺沃—诺迪斯克保健股份有限公司 | Mixing device with piston coupling arrangement |
US8795226B2 (en) | 2009-06-25 | 2014-08-05 | Sanofi-Aventis Deutschland Gmbh | Cannula assembly for co-delivery of medicaments |
US20120191066A1 (en) | 2009-06-25 | 2012-07-26 | Sanofi-Aventis Deutschland Gmbh | Prefilled Cannula Assembly |
WO2011003817A1 (en) | 2009-07-07 | 2011-01-13 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device having mechanical display adjustable by mounting a drug cartridge |
EP2453948B1 (en) | 2009-07-15 | 2015-02-18 | DEKA Products Limited Partnership | Apparatus, systems and methods for an infusion pump assembly |
BR112012003971A2 (en) | 2009-08-27 | 2016-03-29 | Sanofi Aventis Deutschland | time-related information reminder device for a pen-shaped medical dispensing device, such pen-shaped medical dispensing device, uses such medication dispensing device and method of manufacturing or arming such medication dispensing device |
DK2480268T3 (en) | 2009-09-23 | 2016-12-12 | Sanofi Aventis Deutschland | Interior and indicator for pharmaceutical feed device |
US9402959B2 (en) | 2009-09-23 | 2016-08-02 | Sanofi-Aventis Deutschland Gmbh | Assembly for a drug delivery device and drug delivery device |
EP2515968B1 (en) | 2009-12-23 | 2017-09-20 | Becton, Dickinson and Company | Monodose nasal drug delivery device |
BR112012019101A2 (en) | 2010-02-05 | 2016-09-13 | Sanofi Aventis Deutschland | drug module with dual use button and drug delivery system. |
AU2011221472B2 (en) | 2010-03-01 | 2013-08-29 | Eli Lilly And Company | Automatic injection device with delay mechanism including dual functioning biasing member |
US8396447B2 (en) | 2010-08-27 | 2013-03-12 | Don Reich | Emergency call notification system and method |
US9084849B2 (en) | 2011-01-26 | 2015-07-21 | Kaleo, Inc. | Medicament delivery devices for administration of a medicament within a prefilled syringe |
CA2829773A1 (en) | 2011-03-18 | 2012-09-27 | Abbvie Inc. | Systems, devices and methods for assembling automatic injection devices and sub-assemblies thereof |
RU2620351C2 (en) | 2011-09-22 | 2017-05-24 | Эббви Инк. | Automated injector |
MX343467B (en) | 2011-09-22 | 2016-11-07 | Abbvie Inc | Automatic injection device. |
NZ595367A (en) | 2011-09-23 | 2012-02-24 | Nexus6 Ltd | A dose counting mechanism adapted to enclose a medicament delivery device |
WO2013086292A1 (en) | 2011-12-09 | 2013-06-13 | Enject, Inc. | Glucagon formulations |
US10748449B2 (en) | 2012-04-04 | 2020-08-18 | Noble International, Inc. | Medicament delivery training device |
US9522235B2 (en) | 2012-05-22 | 2016-12-20 | Kaleo, Inc. | Devices and methods for delivering medicaments from a multi-chamber container |
CA2896708A1 (en) | 2012-12-27 | 2014-07-03 | Kaleo, Inc. | Devices, systems and methods for locating and interacting with medicament delivery systems |
JP6560187B2 (en) | 2013-03-15 | 2019-08-14 | ウインドギャップ メディカル インコーポレイテッド | Portable drug mixing and delivery system and method |
CA2980004C (en) | 2015-03-24 | 2023-10-10 | Kaleo, Inc. | Devices and methods for delivering a lyophilized medicament |
GB2556479B (en) | 2015-06-30 | 2022-09-07 | Kaleo Inc | Auto-injectors for administration of a medicament within a prefilled syringe |
EP3558420A4 (en) | 2016-12-23 | 2020-05-27 | Kaleo, Inc. | Medicament delivery device and methods for delivering drugs to infants and children |
WO2018136413A2 (en) | 2017-01-17 | 2018-07-26 | Kaleo, Inc. | Medicament delivery devices with wireless connectivity and event detection |
-
2006
- 2006-02-01 JP JP2007553358A patent/JP4948422B2/en active Active
- 2006-02-01 CA CA 2594627 patent/CA2594627C/en active Active
- 2006-02-01 WO PCT/US2006/003415 patent/WO2006083876A2/en active Search and Examination
- 2006-02-01 CA CA2762072A patent/CA2762072C/en active Active
- 2006-02-01 NZ NZ560516A patent/NZ560516A/en not_active IP Right Cessation
- 2006-02-01 CA CA2976873A patent/CA2976873C/en not_active Expired - Fee Related
- 2006-02-01 EP EP06719987A patent/EP1843812A4/en not_active Withdrawn
- 2006-02-01 US US10/572,148 patent/US7749194B2/en active Active
- 2006-02-01 MX MX2007009152A patent/MX2007009152A/en active IP Right Grant
- 2006-02-01 CN CN2006800037480A patent/CN101111281B/en active Active
- 2006-02-01 GB GB0713202A patent/GB2440039A/en not_active Withdrawn
- 2006-02-01 EP EP20090150135 patent/EP2058020B1/en active Active
- 2006-02-01 PL PL09150135T patent/PL2058020T3/en unknown
- 2006-02-01 GB GB0818178A patent/GB2451769B/en active Active
- 2006-02-01 AU AU2006210865A patent/AU2006210865B2/en active Active
- 2006-02-01 ES ES09150135T patent/ES2396745T3/en active Active
- 2006-02-01 DK DK09150135T patent/DK2058020T3/en active
-
2007
- 2007-02-05 US US11/671,025 patent/US8172082B2/en active Active
- 2007-03-28 US US11/692,359 patent/US8123719B2/en active Active
- 2007-07-12 IL IL184552A patent/IL184552A/en active IP Right Grant
-
2009
- 2009-03-04 AU AU2009200841A patent/AU2009200841B2/en active Active
- 2009-07-20 HK HK09106597A patent/HK1126992A1/en unknown
-
2010
- 2010-06-18 US US12/818,496 patent/US8690827B2/en active Active
-
2011
- 2011-12-15 US US13/326,959 patent/US8920367B2/en active Active
-
2012
- 2012-05-04 US US13/464,234 patent/US8544645B2/en active Active
-
2014
- 2014-04-03 US US14/244,311 patent/US9724471B2/en active Active
- 2014-12-22 US US14/579,298 patent/US9867938B2/en active Active
-
2015
- 2015-10-05 US US14/875,085 patent/US10071203B2/en active Active
-
2017
- 2017-07-17 US US15/651,305 patent/US10835673B2/en active Active
-
2018
- 2018-08-31 US US16/119,138 patent/US10918791B2/en active Active
-
2021
- 2021-01-20 US US17/153,254 patent/US20210138152A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US10835673B2 (en) | Devices, systems, and methods for medicament delivery | |
US11135374B2 (en) | Medicament delivery and simulation system with a removable disposable container for medicament delivery and training | |
JP4549079B2 (en) | Medical dosing device | |
GB2456245A (en) | An auto-injector with recorded speech output | |
AU2012201481B2 (en) | Devices, systems, and methods for medicament delivery | |
JP2011005279A (en) | Medical administration apparatus | |
JP2011005280A (en) | Medical administration apparatus | |
JP4873061B2 (en) | Medical dosing device |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request |