CA2682463A1

CA2682463A1 - Balloon fold design for deployment of bifurcated stent petal architecture

Info

Publication number: CA2682463A1
Application number: CA002682463A
Authority: CA
Inventors: Benjamin Arcand
Original assignee: Individual
Current assignee: Boston Scientific Ltd Barbados
Priority date: 2007-03-30
Filing date: 2008-03-27
Publication date: 2008-10-09
Also published as: EP2134404B1; WO2008121698A3; US20080243221A1; JP2010523211A; WO2008121698A9; WO2008121698A2; ATE553808T1; EP2134404A2; JP5113240B2; US8647376B2

Abstract

A balloon fold design for efficient expansion of a side branch assembly in a bifurcated stent. The design involves forming a cup arrangement by folding the radial end of the side branch balloon structure into the luminal end of the side branch balloon structure and then folding the cup down into an orderly discus arrangement. The folding pattern allows for the side branch balloon structure to inflate in a sweeping rotational manner efficiently pushing the side branch assembly petals out and away from the main body of the stent with a low risk of the balloon becoming entangled or damaged by its contact with the petals. The design also allows for the expansion force to be applied at the appropriate time in the optimally needed direction by initially being oriented in a predominantly circumferential direction which is gradually shifting to a predominantly radial direction. In addition, the fold design reduces the overall volume and profile of the side branch balloon structure.

Description

Balloon Fold Design for Deployment of Bifurcated Stent Petal Architecture CROSS-REFERENCE TO RELATED APPLICATIONS
Not Applicable STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH
Not Applicable BACKGROUND OF THE INVENTION
Field of the Invention In some embodiments this invention relates to implantable medical devices, their manufacture, and methods of use. Some embodiments are directed to deliveiy systeins, such as catheter systems of all types, which are utilized in the deliveiy of such devices.

Description of the Related Art Balloon catheters are ein.ployed in a variety of medical procedures.
One such procedure is angioplasty which is a well lcnown medical practice used in the treatinent of diseased arteries in the vasculature of a patient. Using angioplasty procedures, alone, however, involves a risk of restenosis of the artery, which may necessitate another angioplasty procedure, a surgical bypass procedure, or some method of repairing or strengthening the area. Therefore, it has become more common practice to use a catheter-delivered sterit to prevent restenosis and to reinforce and strengthen wealcened vessel walls.
A stent is a medical device introduced to a body lumen and is well known in the art. Stents, grafts, stent-grafts, vena cava filters, expandable frameworlcs, and similar implantable nledical devices, collectively referred to hereinafter as stents, are radially expandable endoprostheses which are typically intravascular implants capable of being implanted transluminally and eil.larged radially after being introduced percutaneously. Typically, a stent is implanted in a blood vessel at the site of a stenosis or aneuryszn endoluniinally, i.e. by so-called "zminimally invasive techniques" in which the stent in a radially reduced configuration, optionally restrained in a radially compressed configuration by a sheath andlor catheter, is delivered by a stent delivery system or "introducer" to the site where it is required. The introducer may enter the body from an access location outside the body, such as through the patient's skin, or by a"cut down"
technique in which the entry blood vessel is exposed by minor surgical means.
After being introduced percutaneously, stents can be expanded by an internal radial force, such as when mounted on an inflatable balloon. Stents can also be self-expanding or a combination of self-expanding and balloon expandable (hybrid expandable). Stents may be implanted to prevent restenosis following angioplasty in the vascular system. Stents may be expanded and irnplanted in a variety of body lumens or vessels such as within the vascular system, urinary tracts, bile ducts, fallopian tubes, coronary vessels, secondary vessels, etc.
A number of complications arise when stenoses forin at vessel bifurcation sites. A bifurcation site is an area of the vasculature or other portion of the body wliere a first (or parent) vessel is bifiucated uito two or more branch vessels. Where a stenotic lesion or lesions form at such a bifurcation, the lesion(s) can affect oiAy one of the vessels (i.e., either of the branch vessels or the parent vessel) two of the vessels, or all three vessels. One complication involves irregular folding of the balloon or balloon portion which pushes against and moves that portion of the stent which expands into the vessel bifurcation. While auxiliary portions of a delivery system have been successful in expanding portions of stents into a side branch vessel, there remains a need for devices that are particularly suitable for expanding stents at a bifurcation to achieve an ideal expanded configuration.
The art referred to and/or described above is not intended to constitute an adniission that any patent, publication or other information referred to herein is "prior art" with respect to this invention All US patents and applications and all otlier published documents mentioned anywhere in this application are incorporated herein by reference in their entirety.

Without limiting the scope of the invention a brief suinmaiy of some of the claimed embodiments of the invention is set forth below. Additional details of the summarized embodinients of the invention and/or additional embodiinents of the invention may be found in the Detailed Description of the Invention below.
BRIEF SUMMARY OF THE INVENTION

This invention contemplates a number of embod'unents where any one, any combination of some, or all of the einbodiments can be incorporated into a stent and/or a stent delivery system and/or a method of use. The present invention relates to novel folding arrangement for inflation balloons. The inflation balloons are folded in a systematic pattern which aids in the proper deployment of the side branch assembly of the stent. Zn particular, the improved folding arrangement aids in the deployment of the extending meinbers relative to the bifurcated vessel wall.
These and other aspects of the invention are set foith below.
At least one embodinlent of the invention is directed to a balloon catheter comprising a balloon inflation system. The balloon inflation system has a side branch balloon stzuctue capable of at least partially expanding a side branch structure of a bifurcated stent. When in an un-inflated configuration, the side branch balloon structure is folded in a pattern which perinits orderly unfoldiiig when the side branch is inflated. Contemplated embod'nnents include a main branch balloon structure capable of inflating a main tubular body of a bifurcated stent which is cither in or not in fluid cominunication wifih the side branch balloon structure.
At least one embodiunent of the invention is directed to a side branch balloon structure coxnpzxsing a radial end, a luminal end, and a side portion extending between the radial and luminal ends. When in the inflated configuration, the radial end is fiu-ther away from the lnain branch central axis than the lumuial end, and when in the un-inflated configuration the radial and luininal ends are substantially adjacent to each other. When in the un-inllated configuration, the side bran.ch balloon structure can be folded such that: at least some of the side portion lies flush against and over the radial end, at least soine of the side portion is further folded into pleats, and/or at least some of the side portion is fiu ther folded into overlapping folds. The side portion can also be folded such that: it is folded into three or more segments with overlapping regions between the folded segments, at least one segnzent lies above one overlapping region and beneath one overlapping region, every folded segmen.t lies above one overlapping region and beneath one overlapping region, at least some of the overlapping folds are of different sizes, at least some of the pleats are of different sizes, and/or the pattern is generally unifozm about a side branch axis.
At least one embodiment of the invention is directed to a balloon catheter further comprising a catlieter shaft disposed about which is a bi$u=cated stent.
The bifurcated stent has a main tubular body and a side branch structure having an iris and a crown configuration. When in the crown configuration at least a portion of the side branch assembly defines a fluid lumen in fluid communication with main tubular body and extends away from the main tubular body at an oblique angle. When in the iris configuration at least a portion of the side braneh assembly is positioned adjacent to the orderly folded side branch balloon structure. The side branch asseinbly can also comprise one or more petals which when crowned define at least a porkion of the second fluid lumen. The folded pattern results in the positioning of smooth portions of the side branch balloon structure against the petais. These smooth portions can be without folds and can cause a portion of the side branch balloon structure to iulflate in a sweeping rotational motion. In addition, the patteiii can allow for at least a portion of the side branch balloon structure to inflate by fu-st primarily expandzng in a circumferential direction away from a center of the side branch balloon structure and later primaiily expanding in a radial direction.
At least one enibodiment of the invention is directed to a method of folding a side branch balloon stucture coniprising the steps of; forn-ting a cup by fold'uig a iadial end of the a side branch balloon structure into a luminal end of the side branch balloon stracture and forming a discus by smoothly folding down the most radial portion of the cup against the radial end of the side branch balloon structure. The method can further including the steps of inflating the side branch balloon, deflating the side branch balloon, and criinping an unexpanded side branch assembly of an unexpanded bifurcated stent over the folded side branch balloon structure.

BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWINGS
The invention is best understood from the following detailed description when read in connection with accompanying drawings, in which:
Figure 1 is a cross sectional perspective view of an inflated bifurcating balloon on a balloon catheter.
Figure 2 is a schematic perspective view of an expanded bifurcated stent on a balloon catheter.
Figure 3 is a cross sectional schematic view of a bifurcating balloon.
Figure 4 is a cross sectional scheinatic view of a bifurcating balloon which is irregularly compressed.
Figure 5 is a cross sectional schematic view of a bifurcating balloon being systematically folded.
Figure 6 is a cross sectional schezza.atic view of a bifurcating balloon systematically folded into a cup configuration.
Figure 7 is an overhead view cross sectional schematic view of a systematically folded bifurcating balloon.
Figure 8 is a cross sectional scheinatic view of an inflated bifurcating balloon in a dual lumen type inflation assembly.
Figure 9 is a cross sectional schematic view of a bifurcating balloon in a dual lumen type inflation assembly systematically folded into a cup configuration.
Figure 10 is a cross sectional schematic view of a bifurcating balloon in a dual lumen type inflation asseinbly systematically folded into a discus configuration.
Figure 11 is a cross sectional schematic view of an iirflated bifurcating balloon in a single lumen type inflation assembly.
Figure 12 is a cross sectional schematic view of a bifurcating balloon in a single lumen type inflation assembly systematically folded into a cup configuration.
Figure 13 is a cross sectional schematic view of a bifurcating balloon in a single lumen type inflation assembly systematically folded into a discus configuration.
Figure 14 is a detailed overhead scheniatic view of a systematically folded bifurcating balloon.
Figure 15 a detailed cross sectional overhead schematic view of a systematically folded bifurcating balloon.
Figure 16 is a detailed overhead sclieniatic view of a systematically pleated bifurcating balloon, Figure 17 is a detailed overhead schematic view of a systematically folded and pleated bifurcating balloon.
Figure 18 is a detailed overhead cross sectional schematic view of a systematically folded and pleated bifurcating balloon.
Figure 19 is a cross sectional scheinatic view of a systematically folded bifurcating balloon beneath a stent side branclr assembly.
Figure 20 is a cross sectional schezxa.atic view of a systenlatically folded bifurcating balloon beneath a stent side branch assembly with a bulging radial end.
Figure 21 is a cross sectional schematic view of a systematically folded bifurcating balloon beneatli a stent side branch assembly with a bulging radial end that is crowning the side branch assembly.
Figure 22 is a cross sectional schematic view of a systematically folded bifurcating balloon which has reversed its cup configuration.
Figure 23 is a cross sectional schematic view of an inflated systematically folded bifurcating balloon about which is disposed a crowned sent side branch assembly.
Figure 24 is a cross sectional schematic view of an unexpanded bifurcating balloon catheter system positioned withixi a bifurcation site.
Figure 25 is a cross sectional schematic view of an expaiided bifiucating balloon catheter system which has deployed a stent within a bifurcation site.

DETAILED DESCRIPTION OF THE INVENTION
The invention will next be illustrated with reference to the figures wherein the same numbers indicate similar elements in all figures. Such figures are intended to be illustrative rather than limiting and are included herewith to facilitate the explanation of the apparatus of the present invention.
For the purposes of this disclosure, like reference numerals in the figures shall refer to like features unless otherwise indicated.
Depicted in the figures are various aspects of the invention.
Elements depicted in one figure may be combined witli, or substituted for, elenxents depicted in another figure as desired.
Embodiments of the invention are directed to folding arrangements of both multiple lumen type and single lunien type balloon catheters.
Referring now to FIG. 1, there is shown a inultiple balloon type catheter (2) along whose main catheter shaft (7) is an expanded side balloon structure (5). FIG. 2 shows disposed about the inflated side balloon stru.cture (5) and the inflated main catheter balloon (3) a bifurcated stent (1) in an expanded state. Some examples of niultiple lumen catheters are discussed in published US Patent Publication Nos. US
2003/0163082, US 2005/0015108A1, and US 2005/0102019A1 and co-pending, concurrently filed, and commonly owned U.S. Application having an Attorney Docket Number of S63.2B-13216-USO1 the entire disclosure of which are incorporated herein by reference in their entirety. The multiple lu~jien type balloon catheter (2) comprises at least two balloons. One is the main catheter balloon (3) and the other is the side branch balloon (6). The side branch balloon (6) comprises a side balloon structure (5) in fluid communication with a side inflation lumen (8).
Some exainples of single balloon type balloon catheters are discussed in published US Patent Publication No. US 2004/0138737 Al the entire disclosure of which is incorporated herein by reference in its entirety. In a single balloon type balloon catheter, iurtegrated into the material of the main catheter balloon is a blister or bulge which defines the side balloon stzucture (5). As the main catheter balloon is inflated, its side balloon structure (5) inllates as well.
Refert-ing again to FIG. 2 it is shown that the stent (1) comprises two portions, a generally tubular main stent body (10) which defines a primary fluid lumen (14) and a side branch assembly (30). The stent (1) has an expanded and an unexpanded state. When in the expanded state, the stent (1) assumes a greater volume than when in the unexpanded state. The main stent body or main branch (10) of the bifurcated stent (1) extends about a main branch central axis (16). The main stent body (10) can be expanded by pressure applied to the inner surface of the naain stent body (10) by the inflation of the main catheter balloon (3), it can be inflated by a self-expansion mechanism, or it can be expanded by some combination of the two.
When the stent (1) is in the expanded state, the side branch assembly or side branch (30) fortns a bifurcating side branch which defines a secondary fluid lumen (34) in fluid communication with the primaiy fluid lumen (14). The side branch assembly extends about a side branch axis (46). This side branch is capable of extending in a radial d'u=ection (31) out of the parent vessel and into the branch vessel. In at least one en7bodiment, the side branch assembly (30) comprises one or more petals (32). For purposes of this application the definition of the ternl "petal"
is one or more side branch members capable of twisting, bending, pivoting or otherwise opening to define the second fluid lumen (34) by opening away fronl the tubular shape defmed by the generally tubular structure of the outer surface of the first stent body (10). It will be appreciated by persons of ordinary skill in the art that side branch assemblies can also conipixses non-petal structures. As a result, all embodiments in this application which describe petals will be understood to contemplate non-petal type side brancli assemblies as well.
The petals (32) can be aiTanged in an iris configuration when the stent (1) is unexpanded and in a crown configuration wla.en the stent (1) is expanded.
For purposes of this application the definition of the terin "iris" is when one or more petals (32) are generally lying along the tubular shape defined by the generally tubular structure of the outer surface of the first stent body (10) and are coveriiig at least a portion of a side branch opening (18) in the main stent body (10). For purposes of this application the definition of the term "crown" is when as at least one petal (32) are positioned at an oblique angle radially displaced from the tubular shape defined by the generally tubular structure of the outer surface of the first stent body (10). For the purposes of this application, the definition of the ternZ
"oblique"

is an angle of greater than zero degrees, such as an angle of between about 1 and about 180 degrees. An oblique angle explicitly in.cludes angles of both exactly and about 90 degrees. The petals (32) are pushed from the iris configuration into the crown configuration at least in part by pressure applied to the inner surface of the petals (32) by the iilflation of the a side balloon structure (5).
Before expansion, when in the unexpanded state, the side balloon structure (5) is in an un-inflated configuration. When this un-inflated configuration is the result of deflation and/or the application of a generaily untargeted force in the luminal (towards the stent lumen) direction (35) or one or more generally untargeted forces along at least a portion of the radial end (60), the luminal end (59), and/or the side length (58) of the side balloon structure (5) (as shown in FIG. 3), the un-inflated balloon assumes an irregular shape. As FIG. 4 illustrates, simple compressive force causes the balloon folds (57) and the overall assumed shape to be randomly forined due to the inconsistent and random buckling and pleating that takes place within the balloon material. Only a small portion if any of the inner suiface of the radial end (60a) and the inner surface of the luminal end (59a) of the side balloon structure (58) come into direct contact with each other and are separated by material from other portions of the side balloon stiucture.
In at least one embodinaent of the invention, the side balloon sti~zcture (5) when in the unexpanded state is configured according to an oi-ganized arrangement. Referring now to FIG. 6 there is shown one such organized arrangement, the "cup" arrangen-ient. When the side balloon structure (5) is in the cup arrangement, at least a portion of the inner surface of the radial end (60a) and the irnler surface of the luminal end (59) are substa.ntially flush with one another.
Similarly at least a portion of the itiner side of the upper ends of the side lengths (58a") and the inner side of the lower ends of the side lengths (58a') are also substantially flush with one another. The cup arrangement is characterized by a folded interface (56) being foznaed between the upper and lower ends of the side balloon structure. FIG. 9 illustrates the cup aiTangement in a dual lumen type balloon catheter and FIG. 12 illustrates the cup arrangement in a single lumen type balloon catlieter.

As illustrated in FIG. 5, in at least one embodiunent, the cup arrangement is formed by the application of a compressive force in the luminal direction (35) evenly distributed along the entirety of the radial end (60) and vectored towards the luminal end (59). This force can be applied in combination with a mandrel which keeps the side lengths (58) straight and x-igid. This applied force will cause a folded interface to fonn between that portion of the side length (58) that is pushed internal to the inner side of the lower ends of the side lengths (58a') and that portion which remains external to the inner side of the lower ends of the side lengths (58a'). As portions of the side length (58) are pushed internal to the inner side of the lower ends of the side lengths (58a'), a lip (29) forms.
In at least one embodiment the cup arrangement is formed by the application of a luminally directed (35) force focused towards the center of the radial end (60) of the side balloon stiucture (5). This focused force cooperates with a side directed force that pushes that portion of the upper end of the balloon material internal to the inner side of the lower ends of the side lengths (58a') to be flush with the inner side of the lower ends of the side lengths (58a'). The side balloon structure (5) can folded while, before, or after the main stent body inflating balloon or balloon portion is iiiflated or collapsed.
Referring now to FIG. 7 there is shown at least one einbodiment of the invention wliere at least some of the upper ends of the side lengths (58a"
and 58b") and lower ends of the side lengtlis (58a' and 58b') are folded according to a "discus" arrangement. The discus arrangement can be cooperative with a cup arrangement or independently arranged. In a discus arrangement, at least a portion of the outer surface of the upper end of the side length (58a") is folded in such a manner that it lies flush against the outer surface of the radial end (60b).
In at least one embodiment illustrated in FIG. 7, the discus arrangement in the side balloon structure (5) has generally organized arrangement of pleats (40) in the folded balloon material. These pleats (40) can be evenly spaced about the coinpressed side balloon structure (5). Because those portions of the balloon inaterial closer to the center of the side balloon stTucture (5) have less area for their xnaterial to be spread about, the pleats (40) are present in portions of the balloon material closer to the center of the side balloon structure (5).
Refeiring now to FIGs 10 and 11, it can be understood because the pleats allow for overlap of balloon material in the smaller central region of the side balloon structure (5) in the discus arrangement, they can be located at or near the lip (29) between the upper and lower ends of the side length of the side balloon structure (5).
In at least one embodiment illustrated in FIGs. 14 and 15, at least a portion of the side balloon structure (5) is in a discus arrangement where the overlapping folds of material (27) are in an inter-layered arrangement. FIG.

illustrates a top down view of this structure and FIG. 15 delineates with pllantom lines the covered folded scgments of balloon material (20). For purposes of this application, the term inter-layered is defined as an arrangement in whieh one side of an object is positioned above the adjaccnt side of a first adjacent object and the other opposite side of the object is positioned below the adjacent side of a second adjacent object. FIGs. 14 and 15 illustrate a segment (20) of the compressed side balloon structure (5) where the portion of a first end (20a) in a first overlapping region (41') is positioned above the material of at least one adjacent folded segment (20') and a second end (20b) overlapping region (41') is positioned below the material oaf at least one adjacent folded segment (20"). The inter-layered arrangement provides at least two advantages. First during inflation as each segment is pushed in a radial direction, each inter-layered segment radially pushes the adjacent segment reducing the overall energy needed to radially push all of the segments. Secondly while inflating, the arrangements cause the segments to move in a rotational direction (43).
This rotational direction (43) provides a precisely directed puslhing force against the crowning side branch assembly, and by sweeping each of the petals in a different tangential direction, reduces the lilcelihood of petals colliding with each other wlien crowning. The phantom lines in FIG. 15 shown at least one embodiment where the overlapping regions (41) become progressively smaller the further they are from the center of the side balloon stiucture (5).
Referring now to FIG. 16 there are shown an embodiment in which the discus arrangement features a plurality of evenly spaced pleats (40). The evenly spaced pleats (40) when inflated at least partially push the petals in different direction reducing the likelihood of petal collisions. FIGs. 17 and 18 illustrate embodiments having combinations of the features of FIGs. 14 and 16. FIGs. 17 and 18 show both one or more pleats (40) and one or more folded overlapping regions (41). In addition they show that if one segment (20) of balloon material has a highly overlapping region at one end (45") it can also have a less overlapping region (45') at the other end of that segment. Modifying the degree of overlap at different segment ends allows for modulation in the rotational sweep and speed witll which different portions of the side balloon structure (5) will attain during inflation. Such modulation facilitates expansion of irregularly shaped side branch structures.
The various flush and even folding arrangements iinpart a number of advantages to the inflation process of the side balloon structure (5). One advantage is that the folding arrangement allows for control over the sequence of the inflation of particular poi-tions of tlie side balloon structure allowing forces to be applied in a desired sequence. Another advantage is that they allow for the sniootli and even expansion of the outer surface of the radial end (60b) as it moves ra.dially (31) away from the lurninal end (59). Also, the organized unfolding that the side balloon undergoes has a predictable sweeping motion which is cooperative with the crowning motion of the petals. This predictable sweeping motion reduces or prevents shear forces which cau be caused by erratic motion that accompanies the iulflation induced smoothing out of eiYatically shaped fold lines and erratically positioned portions of the side balloon structure (5). The sweeping motion with which the organized folds and pleats unfold when expanded also reduces wasted inflation energy that would othei-wise accoinpany untangling and untwisting erratically positioned portions of the side balloon structure (5). The organized folding designs are also repeatable and can be easily integrated into industrial production lines. In addition, the organized structures reduce the likeliliood of unwanted volume producing voids occupying the side branch structure (5) reducing its overall profile. Similarly, the flush and even folding arrangenaents when inflated allow for an increase in side balloon structure (5) volume at a uniform or predictable rate volume which reduces rapid fluctuations in the velocity of the balloon inflation which would otherwise accompany the inflation of dissimilarly folded portions.
The organized arrangeinent also allows for application of precise pushing force to be applied by the outer surface of the radial end (60b) against the petals. This precise pushing force increases inflation efficiency by assui-ing that inajority of the voluinetric expansion can be hanressed to crown the side branch assembly. FIGs 19-23 illustrate one embodiment in which the precise pushing force is applied efficiently to petals (32), other portions of the side branch assembly (30), other portions of the balloon, or any other object positioned over the side balloon structure (5) In FIGs. 19-23 there is shown at least one enzbodiunent of a side balloon structure (5) having a cup and discus arrangenlent where the blunt unfocused radial force that the inflation of the side balloon structure (5) of would produce is replaced by an orderly, sequential, and precisely directed series of forces. When the side balloon structure (5) inflates, first the discus arrangement at least partially unfolds, after which the cup arrangement is rcairanged as the balloons volume is increased. As shown in FIG. 19, prior to inflation, the folded side balloon structure (5) has a low cross sectional profile, Although FIG. 19 illustrates a volume void between the folded side Iengtlis equal to the volume of the lengths it will be understood that significantly greater or lesser void volumes are conteinplated by this invention.
As illustrated in FIGs, 20 and teinporally subsequent FIG, 21, when the side balloon stl-ucture (5) begins its inflation, the outer surface of the radial end (60b) bulges radially before otlier portions of the side balloon structure (5). As shown in FIGs. 21 and 22, this initial bulging applies a controlled radially directed pressing force against the folded side lengths (58). The radially directed pressure pushes the side lengths in a sweeping path compliinentazy to the bending or twisting motions that the petals (32) will undergo as they transition from an iiis to a crown configuration. In particular, because the radial bulge (36) is more luminal at its center than an its edges, the radial bulge (36) applies more pushing force against the petal summit (38) and less against the petal base (42) providing torque which is highly cooperative to the beiiding and twisting motion needed for successful crowning.
Because the folding arrangement, limits the allowed initial motions to the side lengths (58) in an outwardly directed arced path there is a greatly reduced the amount of friction, rubbing or chaffing between the petal and the unfolding side balloon structure (5). In addition, because the petals (32) begin to bend outward (and away from majority of the mass of the side branch structure(5)) at the very beginning of the inflation process, the likelillood of an erratic motion by a portion of the balloon deforming, distorting, or otherwise improperly extending the side branch assembly becomes reduced. Lastly because the initial inflation process moves the petals, the petals develop outwardly directed momentum wh.ich reduces the overall energy needed to extend the petals (32).
Referring now to FIG. 22 tllere is shown that after the discus arrangement beconles somewhat unfolded the cup arrangement then becomes unfolded as well. The radially directed (31) force described in FIGs. 19, 20, and 21 declines and is replaced by outward a force directed in outward directions (37) parallel to axes extending fi=om the center of the side opening (18) to the inain stent body (10). This gradual replacement of the radially directed force with the outwardly directed force is coinpliinentary to the direction vector of the petals as they gradually transition from a substantially iris configuration to a substantially crowned configuration. Because as the petals bccome more crowned the petal tips (38) arc from a primarily radial trajectoiy (31 of FIG. 20) to a primarily outward trajectoiy (37) the sequence of inflation matches the niotion of the petals resulting in highly efficient inflation system.
Referring now to FIG. 19, in at least one embodiment, to facilitate the inflation properties of the side balloon structure (5), the radial side (60) is thimier than (60) the side length (58). By folding the side balloon structure (60) into discus arrangements, the thicker of the materials abuts the side branch assembly (30) reducing the lilcelihood that a portion of balloon will be iaptured or otherwise damaged by impacting against thc side branch assembly (30).
Referring now to FIGs. 24 and 25 there is shown the main catheter balloon (3) and the side balloon structure (5). The main catheter balloon (3) and the side balloon structure (5) are in fluid communication which allows the main catheter balloon (3) and the side balloon structure (5) to undergo comnion inflation and deflation. FIG. 24 illustrates a balloon catheter (2) in the unexpaxided state and FIG.
25 in the expanded state. These figures also show inflation lumens at the distal and proximal sides of the side balloon stiucture (5) which can apply inflatiiag fluid to different portions of the folded side balloon sti-ucture (5).

Embodiments contemplated by this invention include catheters in which the main catheter balloon (3) and the side balloon structure (5) are linked to different fluid sources which allows them to undergo independent inflation and deflation. Similarly two or inore inflation lumens can be positioned at locations about the side balloon strizcture (5). These inflation lumens need not only be distal to or proximal to the side balloon structu.re and can be positioned above, below, or at any position around the side balloon structure (5). Dependuig on the desired sequences of inflation, the catheter may be configured so that each inflation luinen can be independently filled. Alternatively the inflation lumens may be configured to be in coinmon fluidic cominunication with one or nlore of the other inflation Iumens. In addition one or more inflation lumens inay be independent to provide for the withdrawal of fluid from the side balloon structure (5) or may utilize valves to only allow fluid to pass once a desired pressure level is present within the side balloon structure (5) and/or witllin the inflation liunen.
Coordination of the order of inflation, inflation pressure, fluid flux, and fluid flow directions can be coxnbined with the other inflation einbodiments disclosed in this application to facilitate the efficient and successful inflation of the side balloon structure (5). In at least one enlbodiment, at least one of one or more fluid lumens are positioned directly against or inunediately adjacent to one or more balloon portions including but not limited to: a lip, a folded segment, a pleat, a radial end, a luminal end, a side length, a iimer side of a side length, an outer side of a side length, an upper end of a side of a side length, a lower end of a side length, or any combination thereof to facilitate its displacement prior to the displacement by inflation fluid of another second portion of the side balloon structure (5), Sequential displacement can be accomplished by the sequential flow of fluid through a number of specifically positioned lumens against specific side balloon structure portions.
Such coordinated inflation can cause or cooperatively facilitate rotationally directed movement and momentum within the inflating side balloon sti-ucture (5).
In some embodiments the stent, its deliveiy system, or otb.er portion of an assembly may include one or more areas, bands, coatings, members, etc.
that are detectable by imaging modalities such as X-Ray, MRI, ultrasound, etc. In soine embodiments at least a portion of the stent and/or adjacent assembly is at least partially radiopaque.
In some embodiments at least a porfion of the stent is configured to include one or more mechanisms for the delivery of a therapeutic agent. Often the agent will be in the form of a coating or other layer (or layers) of inaterial placed on a surface region of the stent, which is adapted to be released at the site of the stent's implantation or areas adjacent thereto.
The therapeutic agent can be at least one or various types of therapeutic agents including but not limited to: at least one restenosis inbibiting agent that coniprises drug, polyiner and bio-engineered materials or any cona.bination thereof. In addition, the coating can be a tlierapeutic agent such as at least one drug, or at least one other phannaceutical product such as non-genetic agents, genetic agents, cellular material, ete, Some examples of suitable non-genetic therapeutic agents include but are not linlited to: at least one anti-tlirombogenic agents such as heparin, heparin derivatives, vascular cell growth promoters, growth factor inhibitors, Paclitaxel, etc. Where an agent includes a genetic therapeutic agent, such a genetic agent may include but is not limited to: DNA, RNA and their respective derivatives and/or components; hedgehog proteins, etc. Where a therapeutic agent includes cellular material, the cellular material may include but is not limited to: cells of human origin and/or non-huzn.an origin as well as their respective components and/or derivatives thereof. Where the therapeutic agent includes a polymer agent, the polynler agent inay be a polystyrene-polyisobutylene-polystyrene triblock copolymer (SIBS), polyethylene oxide, silicone rubber and/or any other suitable substrate. It will be appreciated that other types of coating substances, well known to those skilled in the art, can be applied to the stent (1) as well.
This conipletes the description of the preferred and alternate embodiments of the invention. The above disclosure is intended to be illustrative and not exhaustive. This description will suggest inany variations and alternatives to one of ordinaty skill in this art. The various elements shown in the individual figures and described above nlay be combined, substituted, or modified for combination as desired. All these altematives and variations are intended to be included within the scope of the clainis wliere the term "comprising" means "including, but not limited to".
Further, the particular features presented in the dependent claims can be combined with each other in other manners within the scope of the invention such that the iiivention sliould be recognized as also specifically directed to otlier embodiiiients having any other possible conibination of the features of the dependent claims. For instance, for purposes of claim publication, any dependent claim which follows should be taken as alternatively written in a multiple dependent form from all prior claims which possess all antecedents referenced in such dependent claim if such multiple dependent format is an accepted fornlat within the jurisdiction (e.g. each claim depending directly from claim 1 should be alternatively talcen as depending from all previous claims). In jurisdictions where multiple dependent claim formats are restricted, the following dependent claims should each be also talcen as alternativeiy written in each singly dependent claim forinat which creates a dependency from a prior antecedent-possessing claim otller than the specific claim listed in such dependent claims below.

Claims

CLAIMS:

1) A balloon catheter comprising a balloon inflation system, the balloon inflation system comprising a side branch balloon structure, capable of at least partially expanding a side branch structure of a bifurcated stent, wherein:
the side branch balloon structure has an inflated configuration and an un-inflated configuration and when in the un-inflated configuration the side branch balloon structure is folded in a pattern which permits orderly unfolding when the side branch is inflated.

2) The balloon catheter of claim 1 further comprising a main branch balloon structure capable of inflating a main tubular body of said bifurcated stent wherein:
the side branch balloon structure and the main branch balloon structure are in fluid communication with each other.

3) The balloon catheter of claim 1 further comprising a main branch balloon structure capable of inflating a main tubular body of said bifurcated stent wherein:
the side branch balloon structure and the main branch balloon structure are not in fluid communication with each other.

4) The balloon catheter of claim 1 further comprising a main branch central axis and wherein:
the side branch balloon structure comprises a radial end, a luminal end, and a side portion extending between the radial and luminal ends, when in the inflated configuration the radial end being further away from the main branch central axis than the luminal end, when in the un-inflated configuration the radial and luminal ends are substantially adjacent to each other.

5) The balloon catheter of claim 4 wherein in the un-inflated configuration, the side branch balloon structure is folded such that at least some of the side portion lies flush against and over the radial end.

6) The balloon catheter of claim 5 wherein at least some of the side portion is further folded into pleats.

7) The balloon catheter of claim 5 wherein at least some of the side portion is further folded into overlapping folds.

8) The balloon catheter of claim 5 wherein the side portion is folded into three or more segments with overlapping regions between the folded segments, at least one segment lies above one overlapping region and beneath one overlapping region.

9) The balloon catheter of claim 8 wherein every folded segment lies above one overlapping region and beneath one overlapping region.

10) The balloon catheter of claim 7 wherein at least some of the overlapping folds are of different sizes.

11) The balloon catheter of claim 6 wherein at least some of the pleats are of different sizes.

12) The balloon catheter of claim 1 wherein the pattern is generally uniform about a side branch axis.

13) The balloon catheter of claim 1 further comprising a stent and a catheter shaft, the stent comprises a main tubular body and a side branch structure having an iris and a crown configuration, the stent is disposed about the catheter shaft, when in the crown configuration at least a portion of the side branch assembly defines a fluid lumen in fluid communication with main tubular body and extends away from the main tubular body at an oblique angle, when in the iris configuration at least a portion of the side branch assembly is positioned adjacent to the orderly folded side branch balloon structure.

14) The balloon catheter of claim 13 in which the side branch assembly comprises one or more petals which when crowned define at least a portion of the second fluid lumen, the orderly folded pattern having smooth portions of the side branch balloon structure lying against the petals.

15) The balloon catheter of claim 13 in which those portions of the side branch balloon structure lie flush against the petals and are not folded.

16) The balloon catheter of claim 1 in which the folded pattern allows for at least a portion of the side branch balloon structure to inflate in a sweeping rotational motion.

17) The balloon catheter system of claim 1 in which the folded pattern allows for at least a portion of the side branch balloon structure to inflate by first primarily expanding in a circumferential direction away from a center of the side branch balloon structure and later primarily expanding in a radial direction.

18) A method of folding a side branch balloon structure comprising the steps of:

forming a cup by folding a radial end of the a side branch balloon structure into a luminal end of the side branch balloon structure;
forming a discus by smoothly folding down the most radial portion of the cup against the radial end of the side branch balloon structure.

19) The method of claim 18 further including the steps of:
inflating the side branch balloon;
deflating the side branch balloon;
crimping an unexpanded side branch assembly of an unexpanded bifurcated stent over the folded side branch balloon structure.