CA2670146A1 - Variable flow infusion pump system - Google Patents

Variable flow infusion pump system Download PDF

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Publication number
CA2670146A1
CA2670146A1 CA002670146A CA2670146A CA2670146A1 CA 2670146 A1 CA2670146 A1 CA 2670146A1 CA 002670146 A CA002670146 A CA 002670146A CA 2670146 A CA2670146 A CA 2670146A CA 2670146 A1 CA2670146 A1 CA 2670146A1
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CA
Canada
Prior art keywords
infusion pump
module
implantable infusion
housing
pump system
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002670146A
Other languages
French (fr)
Other versions
CA2670146C (en
Inventor
Bernd Steinbach
Frank Wallmann
Klaus G. Lederer
David Saar
Sidney David
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Palyon Medical BVI Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CA2792541A priority Critical patent/CA2792541C/en
Publication of CA2670146A1 publication Critical patent/CA2670146A1/en
Application granted granted Critical
Publication of CA2670146C publication Critical patent/CA2670146C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14276—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/141—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor with capillaries for restricting fluid flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/14586—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of a flexible diaphragm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16804—Flow controllers
    • A61M5/16813—Flow controllers by controlling the degree of opening of the flow line

Abstract

An implantable infusion pump system is disclosed. The pump system preferably includes an implantable pump (800) and a removable module (820, 820'). The module (820, 820') may provide for varying flow rates of fluid being dispensed from the pump or may provide for a constant flow rate of such fluid. In the case of varying flow rate capabilities, the module (820, 820') preferably includes one or more sensors (830, 831) to determine information relating to the flow rate, electronics (844, 846, 835, 844e, 844f, 849, 848, 850, 851, 853, 854, 855, 856) for analyzing the flow rate information, and a mechanism for physically altering the flow rate (821). Methods of dispensing a medicament to a patient are also disclosed, as are variations of the pump system.

Claims (126)

1. An implantable infusion pump system for dispensing an active substance at one or varying flow rates to a patient comprising:

a constant flow pump having a housing having an active substance chamber, an outlet duct, and an upper surface; and a removable module having a bottom surface contacting the upper surface of the constant flow pump, such that the module facilitates fluid communication between the active substance chamber and the outlet duct.
2. The implantable infusion pump system according to claim 1, further comprising a catheter for delivering the active substance to a target site within the patient, the catheter attached to the outlet duct.
3. The implantable infusion pump system according to claim 2, wherein the catheter is removably attached to the outlet duct.
4. The implantable infusion pump system according to claim 1, wherein the housing further includes a propellant chamber.
5. The implantable infusion pump system according to claim 4, wherein the housing further includes a first flexible membrane separating the active substance chamber and the propellant chamber.
6. The implantable infusion pump system according to claim 5, wherein the housing further includes a second flexible membrane enclosing the propellant chamber with the first flexible membrane.
7. The implantable infusion pump system according to claim 6, wherein the housing further includes an upper portion and a lower portion.
8. The implantable infusion pump system according to claim 7, wherein the upper and lower portions removably screwed together and capture the first and second flexible membranes therebetween.
9. The implantable infusion pump system according to claim 8, wherein the upper portion includes a first opening allowing for replenishment of the active substance chamber and a second opening allowing for direct injection of a fluid to the outlet duct.
10. The implantable infusion pump system according to claim 9, wherein the first and second openings are covered with septa.
11. The implantable infusion pump system according to claim 1, wherein the upper surface of the housing includes an upstanding extension forming a shoulder.
12. The implantable infusion pump system according to claim 11, further comprising a cap removably connected with the shoulder and covering the module.
13. The implantable infusion pump system according to claim 1, wherein the module further includes a needle valve portion having a longitudinally varying cross section along its length.
14. The implantable infusion pump system according to claim 13, wherein the needle valve portion includes a central point with cross sections on either side of the central point being mirror images.
15. The implantable infusion pump system according to claim 13, wherein the needle valve portion is disposed within a valve body.
16. The implantable infusion pump system according to claim 15, wherein the module further includes means for longitudinally moving the needle portion within the valve body.
17. The implantable infusion pump system according to claim 16, wherein longitudinal movement of the needle portion within the valve body is generally transverse to a flow of a fluid from the active substance chamber through the valve body.
18. The implantable infusion pump system according to claim 16, wherein the means for longitudinally moving the needle portion within the valve body include a motor and an offset cam.
19. The implantable infusion pump system according to claim 16, wherein the means for longitudinally moving the needle portion within the valve body include a motor, an axle, an eccentric cam body and a bearing, the bearing having an interior rotating portion connected to the eccentric cam body and an exterior portion abutting the needle portion.
20. The implantable infusion pump system according to claim 16, wherein the upper surface of the housing includes an exit opening in fluid communication with the active substance chamber and a entrance opening in fluid communication with the outlet duct.
21. The implantable infusion pump system according to claim 20, wherein the module is in fluid communication with both the exit and entrance opening of the housing.
22. The implantable infusion pump system according to claim 21, wherein the module includes an entry in fluid communication with the exit opening of the housing, and an exit in fluid communication with the entrance openings of the housing.
23. The implantable infusion pump system according to claim 22, wherein the module includes a fixed flow restrictor in fluid communication between the entry of the module and the valve body of the module.
24. The implantable infusion pump system according to claim 23, wherein the fixed flow restrictor includes a capillary and a filament disposed within the capillary.
25. The implantable infusion pump system according to claim 23, wherein the module includes first and second pressure sensors for taking pressure readings on either side of the fixed flow restrictor.
26. The implantable infusion pump system according to claim 25, wherein the first and second pressure sensors are disposed within seats formed in a solid material portion of the module.
27. The implantable infusion pump system according to claim 26, wherein the solid material portion is constructed of PEEK.
28. The implantable infusion pump system according to claim 25, wherein during operation of the pump system, a fluid dispelled from the active substance chamber passes through the exit opening of the housing, through the entry of the module, into contact with the first pressure sensor, through the fixed flow restrictor, into contact with the second pressure sensor, through the valve body of the module, through the exit of the module, through the entrance opening of the housing and through the outlet duct.
29. The implantable infusion pump system according to claim 25, wherein the module further includes a processor chip capable of processing pressure information from the first and second pressure sensors to generate information representative of flow rate through the fixed flow restrictor.
30. The implantable infusion pump system according to claim 29, wherein the module further includes an electronic circuit board, the processor chip being mounted on the electronic circuit board.
31. The implantable infusion pump system according to claim 30, wherein the module further includes a power source.
32. The implantable infusion pump system according to claim 31, wherein the power source comprises at least one battery.
33. The implantable infusion pump system according to claim 29, further comprising an antenna for receiving information representative of a demand flow rate from an outside source.
34. The implantable infusion pump system according to claim 33, wherein the outside source is a handheld device.
35. The implantable infusion pump system according to claim 33, wherein the outside source is a network.
36. The implantable infusion pump system according to claim 31, wherein the module is connected to the upper surface of the housing by a fastening means.
37. The implantable infusion pump system according to claim 36, wherein the fastening means comprises at least one screw.
38. The implantable infusion pump system according to claim 37, wherein the screw passes through apertures formed in the electronic circuit board, module and the housing.
39. The implantable infusion pump system according to claim 38, wherein the screw acts to clamp the electronic board to the module and the module to the housing.
40. The implantable infusion pump system according to claim 39, wherein the first and second sensors are held within seats formed in a solid material portion of the module by the screw.
41. The implantable infusion pump system according to claim 40, wherein two screws connect the module to the upper surface of the housing.
42. The implantable infusion pump system according to claim 1, wherein the module is connected to the upper surface of the housing by a fastening means.
43. The implantable infusion pump system according to claim 42, wherein the fastening means comprises at least one screw.
44. The implantable infusion pump system according to claim 43, wherein the screw passes through apertures formed in the module and the housing.
45. The implantable infusion pump system according to claim 1, wherein the module includes a capillary.
46. The implantable infusion pump system according to claim 45, wherein the capillary is a glass capillary.
47. The implantable infusion pump system according to claim 45, wherein the capillary is curved.
48. The implantable infusion pump system according to claim 45, wherein the capillary allows for a predetermined maximum flow rate therethrough.
49. The implantable infusion pump system according to claim 48, wherein the upper surface of the housing includes an exit opening in fluid communication with the active substance chamber and a entrance opening in fluid communication with the outlet duct.
50. The implantable infusion pump system according to claim 49, wherein the module is in fluid communication with both the exit and entrance openings of the housing.
51. The implantable infusion pump system according to claim 50, wherein the module includes an entry in fluid communication with the exit opening of the housing, and an exit in fluid communication with the entrance opening of the housing.
52. The implantable infusion pump system according to claim 51, wherein the capillary is in fluid communication between the entry and exit of the module.
53. The implantable infusion pump system according to claim 52, wherein the module is connected to the upper surface of the housing by a fastening means.
54. The implantable infusion pump system according to claim 53, wherein the fastening means comprises at least one screw.
55. The implantable infusion pump system according to claim 54, wherein the screw passes through apertures formed in the module and the housing.
56. A method of implanting an infusion pump comprising the steps of:

determining the need for a variable or constant flow infusion pump;

selecting, based upon the determining step, a pump housing and a module, the module selected from a variable flow module and a constant flow module;

engaging a bottom surface of the module with an upper surface of the housing to construct the infusion pump, such that the restrictor module is in fluid communication with the housing; and implanting the infusion pump in the body of a patient.
57. The method of claim 56, further comprising the step of attaching a catheter for delivering the active substance to a target site within the patient to an outlet duct of the pump housing.
58. The method of claim 56, wherein the attaching step includes removably attaching the catheter to the outlet duct.
59. The method of claim 56, wherein the selecting step further includes the step of screwing upper and lower portions together to form the pump housing.
60. The method of claim 59, wherein the screwing step includes capturing a flexible membrane between the upper and lower portions of the pump housing.
61. The method of claim 56, further comprising the step of introducing a fluid into an active substance chamber formed in the pump housing.
62. The method of claim 61, wherein the introducing step includes injecting the fluid through a replenishment opening formed in the pump housing.
63. The method of claim 62, wherein the introducing step further includes piercing a septum with a needle.
64. The method of claim 56, further comprising the step of attaching a cap with the pump housing to cover the module.
65. The method of claim 56, further comprising the step of moving a needle portion in a valve body formed in the module to vary a flow rate of fluid dispelled from the pump housing.
66. The method of claim 65, wherein the moving step includes moving the needle portion in the valve body in a direction transverse to the flow of the fluid through the valve body.
67. The method of claim 56, wherein the engaging step includes engaging the module with the upper surface of the pump housing such that an exit opening formed in the pump housing aligns with an entry formed in the module, and such that an exit form in the module aligns with an entrance opening formed in the pump housing.
68. The method of claim 56, further comprising the step of inserting first and second pressure sensors within seats formed in a solid material portion of the module.
69. The method of claim 56, further comprising the step of engaging an electronic board with the module.
70. The method of claim 69, further comprising the step of providing a power source in connection with the electronic board.
71. The method of claim 56, wherein the engaging step includes connecting the module to the upper surface of the housing with a fastening means.
72. The method of claim 71, wherein the engaging step includes screwing at least one screw through the module and into the pump housing.
73. The method of claim 72, further including the step of engaging an electronic board with the module, wherein the screw acts to clamp the electronic board to the module and the module to the housing.
74. The method of claim 73, further comprising the step of inserting first and second pressure sensors within seats formed in a solid material portion of the module, wherein the first and second sensors are held within seats formed in a solid material portion of the module by the electronic board.
75. The method of claim 56, wherein the module includes a capillary.
76. The method of claim 75, wherein the capillary allows for a maximum flow rate therethrough.
77. The method of claim 76, wherein the engaging step includes engaging the module with the upper surface of the pump housing such that an exit opening formed in the pump housing aligns with an entry formed in the module, and such that an exit form in the module aligns with an entrance opening formed in the pump housing.
78. An implantable infusion pump for dispensing an active substance at varying flow rates to a patient comprising:

a constant flow pump having a housing defining an upper surface, an active substance chamber, a propellant chamber separated from the active substance chamber by a first flexible membrane, an outlet duct having a catheter attached thereto, an exit opening in fluid communication with the active substance chamber and a entrance opening in fluid communication with the outlet duct; and a removable module including a bottom surface contacting the upper surface of the constant flow pump, an entry formed in the bottom surface in fluid communication with the exit opening of the housing, an exit in fluid communication with the entrance opening of the housing, a needle valve portion having a longitudinally varying cross section along its length disposed within a valve body, means for longitudinally moving the needle portion within the valve body, a fixed flow restrictor in fluid communication between the entry of the module and the valve body of the module, and first and second pressure sensors for sensing pressure on either side of the fixed flow restrictor, wherein during operation of the pump system, a fluid dispelled from the active substance chamber by a force from the propellant chamber passes through the exit opening of the housing, through the entry of the module, into contact with the first pressure sensor, through the fixed flow restrictor, into contact with the second pressure sensor, through the valve body of the module, through the exit of the module, through the entrance opening of the housing, through the outlet duct, and through the catheter.
79. The implantable infusion pump according to claim 78, wherein the housing further includes a second flexible membrane enclosing the propellant chamber with the first flexible membrane.
80. The implantable infusion pump according to claim 78, wherein the housing further includes an upper portion and a lower portion.
81. The implantable infusion pump according to claim 80, wherein the upper and lower portions are designed to be screwed together and capture the first and second flexible membranes therebetween.
82. The implantable infusion pump according to claim 78, wherein the upper portion includes a first opening allowing for replenishment of the active substance chamber and a second opening allowing for direct injection of a fluid to the outlet duct.
83. The implantable infusion pump according to claim 82, wherein the first and second openings are covered with septa.
84. The implantable infusion pump according to claim 78, wherein the upper surface of the housing includes an upstanding extension forming a shoulder.
85. The implantable infusion pump according to claim 84, further comprising a cap connected with the shoulder and covering the module.
86. The implantable infusion pump according to claim 78, wherein the needle valve portion includes a central point with cross sections on either side of the central point being mirror images.
87. The implantable infusion pump according to claim 78, wherein the means for longitudinally moving the needle valve portion within the valve body include a motor and an offset cam.
88. The implantable infusion pump according to claim 78, wherein the means for longitudinally moving the needle portion within the valve body include a motor, an axle, an eccentric cam body and a bearing, the bearing having an interior rotating portion connected to the eccentric cam body and an exterior portion abutting the needle portion.
89. The implantable infusion pump system according to claim 78, wherein longitudinal movement of the needle valve portion within the valve body is generally transverse to the flow of a fluid from the active substance chamber through the valve body.
90. The implantable infusion pump according to claim 78, wherein the fixed flow restrictor includes a capillary and a filament disposed within the capillary.
91. The implantable infusion pump according to claim 78, wherein the first and second pressure sensors are disposed within seats formed in a solid material portion of the module.
92. The implantable infusion pump according to claim 91, wherein the solid material portion is constructed of PEEK.
93. The implantable infusion pump according to claim 78, wherein the module further includes a processor chip capable of processing pressure information from the first and second pressure sensors to generate information representative of flow rate through the fixed flow restrictor.
94. The implantable infusion pump according to claim 93, wherein the module further includes an electronic circuit board, the processor chip being mounted on the electronic circuit board.
95. The implantable infusion pump according to claim 94, wherein the module further includes a power source.
96. The implantable infusion pump according to claim 95, wherein the power source comprises at least one battery.
97. The implantable infusion pump according to claim 93, further comprising an antenna for receiving information representative of a desired flow rate from an outside source.
98. The implantable infusion pump according to claim 97, wherein the outside source is a handheld device.
99. The implantable infusion pump according to claim 97, wherein the outside source is a network.
100. The implantable infusion pump according to claim 78, wherein the module is connected to the upper surface of the housing by a fastening means.
101. The implantable infusion pump according to claim 100, wherein the fastening means comprises at least one screw.
102. The implantable infusion pump according to claim 101, wherein the screw passes through apertures formed in the module and the housing.
103. The implantable infusion pump according to claim 102, wherein the screw acts to clamp the module and the module to the housing.
104. The implantable infusion pump according to claim 103, wherein the module further includes an electronic circuit board, the at least one screw passing through an aperture formed in the electronic circuit board.
105. The implantable infusion pump according to claim 104, wherein the first and second sensors are held within seats formed in a solid material portion of the module by the electronic circuit board.
106. A method of monitoring the amount of medicament dispensed from an implantable infusion pump, the method comprising the steps of:

providing a pump having the medicament disposed housed therein;

dispensing at least some of the medicament from the pump at varying actual flow rates;

measuring the actual flow rate of the medicament from the pump at least two different times;

storing information relating to the actual flow rate; and calculating the overall amount of medicament dispensed based upon the information relating to the actual flow rate.
107. The method of claim 106, wherein the providing step includes providing a pump housing and a module connected to the pump housing.
108. The method of claim 106, wherein the measuring step includes taking pressure measurements indicative of the actual flow rate.
109. The method of claim 108, wherein pressure measurements are taken at two different locations within the pump.
110. The method of claim 109, wherein the pressure measurements are taken on either side of a fixed flow restrictor included in the pump.
111. The method of claim 109, wherein the pump includes a pump housing and a module attached to the pump housing, the pressure measurements taken within the module.
112. The method of claim 111, wherein the pressure measurements are taken on either side of a fixed flow restrictor included in the module.
113. The method of claim 106, wherein storing step includes transmitting the information relating to the actual flow rate to an external device.
114. The method of claim 113, wherein the external device is a PC.
115. The method of claim 113, wherein the external device is a handheld.
116. The method of claim 106, wherein the storing step includes storing the information relating to the actual flow rate in a memory module associated with the pump.
117. The method of claim 106, wherein the calculating step is performed external to the pump.
118. The method of claim 106, wherein the dispensing step includes dispensing the medicament at a desired flow rate.
119. The method of claim 118, wherein the measuring step includes comparing the desired flow rate to the actual flow rate.
120. The method of claim 119, wherein the actual flow rate is varied when the actual flow rate deviates from the desired flow rate by a first amount.
121. The method of claim 120, wherein the first amount is ten percent of the desired flow rate.
122. The method of claim 120, wherein the actual flow rate is increased when the actual flow rate is a first amount less than the desired flow rate.
123. The method of claim 120, wherein the actual flow rate is decreased when the actual flow rate is a first amount greater than the desired flow rate.
124. The method of claim 106, wherein the calculating step includes determining a first average flow rate for a first period based upon the measuring step, and determining a second average flow rate for a second period based upon the measuring step.
125. The method of claim 124, wherein the calculating step includes determining the first amount of medicament dispensed for the first period and the second amount of medicament dispensed for the second period.
126. The method of claim 25, wherein an overall amount of medicament dispensed from the pump includes adding the first and second amounts.
CA2670146A 2006-11-17 2007-11-15 Variable flow infusion pump system Expired - Fee Related CA2670146C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2792541A CA2792541C (en) 2006-11-17 2007-11-15 Variable flow infusion pump system

Applications Claiming Priority (3)

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US11/601,586 US7637892B2 (en) 2005-05-10 2006-11-17 Variable flow infusion pump system
US11/601,586 2006-11-17
PCT/US2007/024026 WO2008063541A2 (en) 2006-11-17 2007-11-15 Variable flow infusion pumps system

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CA2670146A1 true CA2670146A1 (en) 2008-05-29
CA2670146C CA2670146C (en) 2012-12-18

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US (3) US7637892B2 (en)
EP (1) EP2083905A4 (en)
JP (1) JP5264757B2 (en)
KR (1) KR101426340B1 (en)
AU (1) AU2007322061B2 (en)
CA (2) CA2670146C (en)
MX (1) MX2009005079A (en)
WO (1) WO2008063541A2 (en)

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