CA2651855A1 - Two-piece, internal-channel osmotic delivery system flow modulator - Google Patents
Two-piece, internal-channel osmotic delivery system flow modulator Download PDFInfo
- Publication number
- CA2651855A1 CA2651855A1 CA002651855A CA2651855A CA2651855A1 CA 2651855 A1 CA2651855 A1 CA 2651855A1 CA 002651855 A CA002651855 A CA 002651855A CA 2651855 A CA2651855 A CA 2651855A CA 2651855 A1 CA2651855 A1 CA 2651855A1
- Authority
- CA
- Canada
- Prior art keywords
- flow modulator
- reservoir
- outer shell
- delivery system
- inner core
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/0318—Processes
- Y10T137/0402—Cleaning, repairing, or assembling
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49229—Prime mover or fluid pump making
- Y10T29/49236—Fluid pump or compressor making
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/494—Fluidic or fluid actuated device making
Abstract
An osmotic delivery system flow modulator includes an outer shell constructed and arranged for positioning in an opening of a reservoir of an osmotic delivery system, an inner core inserted in the outer shell, and a fluid channel having a spiral shape defined between the outer shell and the inner core. The fluid channel is adapted for delivery of an active agent formulation from the reservoir of the osmotic delivery system.
Claims (20)
1. An osmotic delivery system flow modulator, comprising:
an outer shell constructed and arranged for positioning in an opening of a reservoir of an osmotic delivery system;
an inner core inserted in the outer shell; and a fluid channel having a spiral shape defined between the outer shell and the inner core, the fluid channel being adapted for delivery of an active agent formulation from the reservoir of the osmotic delivery system.
an outer shell constructed and arranged for positioning in an opening of a reservoir of an osmotic delivery system;
an inner core inserted in the outer shell; and a fluid channel having a spiral shape defined between the outer shell and the inner core, the fluid channel being adapted for delivery of an active agent formulation from the reservoir of the osmotic delivery system.
2. The flow modulator of claim 1, wherein the fluid channel is formed on an outer surface of the inner core which mates with an inner surface of the outer shell.
3. The flow modulator of claim 1, wherein the fluid channel is formed on an inner surface of the outer shell which mates with an outer surface of the inner core.
4. The flow modulator of claim 1, further comprising a flow insert disposed between the outer shell and inner core, wherein the fluid channel is formed in the flow insert.
5. The flow modulator of claim 4, wherein the outer shell, inner core, and flow insert are made of an inert material.
6. The flow modulator of claim 5, wherein the inert material is a non-metallic material.
7. The flow modulator of claim 1, wherein the outer shell and inner core are made of an inert material.
8. The flow modulator of claim 7, wherein the inert material is a non-metallic material.
9. The flow modulator of claim 1, wherein the outer shell sealingly engages the inner core.
10. The flow modulator of claim 1, wherein the inner core includes an outer shoulder and the outer shell includes an inner shoulder, wherein the outer shoulder and inner shoulder engage to prevent expulsion of the inner core from the outer shell in use.
11. The flow modulator of claim 1, wherein a length of the fluid channel ranges from 10 to 50 mm.
12. The flow modulator of claim 1, wherein an effective cross-sectional diameter of the fluid channel ranges from 0.1 to 0.5 mm.
13. An osmotic delivery system, comprising:
a reservoir;
a semipermeable plug disposed at a first end of the reservoir to selectively permit fluid flow into the reservoir; and a flow modulator disposed at a second end of the reservoir, the flow modulator comprising an internal spiral channel adapted for delivery of an active agent formulation contained in the reservoir to a fluid environment in which the osmotic delivery system operates.
a reservoir;
a semipermeable plug disposed at a first end of the reservoir to selectively permit fluid flow into the reservoir; and a flow modulator disposed at a second end of the reservoir, the flow modulator comprising an internal spiral channel adapted for delivery of an active agent formulation contained in the reservoir to a fluid environment in which the osmotic delivery system operates.
14. The osmotic delivery system of claim 13, wherein the flow modulator comprises an outer shell and an inner core inserted in the outer shell, wherein the spiral channel is defined between the outer shell and the inner core.
15. The osmotic delivery system of claim 14, wherein the flow modulator is press-fitted into the second end of the reservoir.
16. The osmotic delivery system of claim 14, further comprising a partition disposed and movable within the reservoir, the partition defining a first chamber containing an osmotic engine and a second chamber containing the active agent formulation, wherein the first chamber is adjacent the semipermeable plug and the second chamber is adjacent the flow modulator.
17. The osmotic delivery system of claim 13, wherein the active agent formulation comprises interferon-omega.
18. An implantable delivery system for an active agent formulation, comprising:
a reservoir made of an impermeable material;
a first chamber in the reservoir containing an osmotic engine;
a second chamber in the reservoir containing an active agent formulation;
a semipermeable plug disposed at a first end of the reservoir adjacent the first chamber; and a flow modulator according to any of claims 1-12 disposed at a second end of the reservoir adjacent the second chamber.
a reservoir made of an impermeable material;
a first chamber in the reservoir containing an osmotic engine;
a second chamber in the reservoir containing an active agent formulation;
a semipermeable plug disposed at a first end of the reservoir adjacent the first chamber; and a flow modulator according to any of claims 1-12 disposed at a second end of the reservoir adjacent the second chamber.
19. The implantable delivery system of claim 18, wherein the active agent formulation comprises interferon-omega.
20. The implantable delivery system of claim 18, further comprising a partition between the osmotic engine and the active agent formulation.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80945106P | 2006-05-30 | 2006-05-30 | |
| US60/809,451 | 2006-05-30 | ||
| PCT/US2007/069990 WO2007140416A2 (en) | 2006-05-30 | 2007-05-30 | Two-piece, internal-channel osmotic delivery system flow modulator |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2651855A1 true CA2651855A1 (en) | 2007-12-06 |
| CA2651855C CA2651855C (en) | 2011-08-02 |
Family
ID=38617914
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2651855A Active CA2651855C (en) | 2006-05-30 | 2007-05-30 | Two-piece, internal-channel osmotic delivery system flow modulator |
Country Status (16)
| Country | Link |
|---|---|
| US (8) | US8052996B2 (en) |
| EP (1) | EP2020990B1 (en) |
| JP (1) | JP5143131B2 (en) |
| KR (1) | KR101106510B1 (en) |
| CN (1) | CN101453982B (en) |
| AT (1) | ATE481963T1 (en) |
| AU (1) | AU2007266475B2 (en) |
| CA (1) | CA2651855C (en) |
| DE (1) | DE602007009377D1 (en) |
| DK (1) | DK2020990T3 (en) |
| ES (1) | ES2351527T3 (en) |
| HK (1) | HK1129203A1 (en) |
| IL (1) | IL194746A (en) |
| MX (1) | MX2008014870A (en) |
| NZ (1) | NZ572003A (en) |
| WO (1) | WO2007140416A2 (en) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY125870A (en) * | 1997-07-25 | 2006-08-30 | Alza Corp | Osmotic delivery system flow modulator apparatus and method |
| US7919109B2 (en) | 1999-02-08 | 2011-04-05 | Intarcia Therapeutics, Inc. | Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles |
| US7258869B1 (en) * | 1999-02-08 | 2007-08-21 | Alza Corporation | Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle |
| US20050070883A1 (en) * | 2000-11-29 | 2005-03-31 | Brown James E | Devices and methods for controlled delivery from a drug delivery device |
| DE60315474T2 (en) * | 2002-06-17 | 2008-04-24 | Alza Corp., Mountain View | OSMOTIC DISTRIBUTION SYSTEMS WITH OSMOTIC DRIVE AND METHOD FOR PRODUCING BOTH THE OSMOTIC DRIVE AND THE OSMOTIC DELIVERY SYSTEM |
| US7731947B2 (en) * | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
| JP2006521897A (en) * | 2003-03-31 | 2006-09-28 | アルザ・コーポレーション | Osmotic pump with means for dissipating internal pressure |
| AR043810A1 (en) * | 2003-03-31 | 2005-08-17 | Alza Corp | OSMOTIC SYSTEM OF ADMINISTRATION AND METHOD TO DECREASE TIMES OF ARRIVAL IN THE OPERATING REGIME IN OSMOTIC SYSTEMS OF ADMINISTRATION |
| PL380763A1 (en) * | 2003-10-31 | 2007-03-05 | Alza Corporation | Osmotic pump with self-retaining, fast-start membrane plug |
| CN1874763A (en) * | 2003-11-06 | 2006-12-06 | 阿尔扎公司 | Modular imbibition rate reducer for use with implantable osmotic pump |
| WO2006083761A2 (en) | 2005-02-03 | 2006-08-10 | Alza Corporation | Solvent/polymer solutions as suspension vehicles |
| EP2361630A1 (en) * | 2005-02-03 | 2011-08-31 | Intarcia Therapeutics, Inc | Implantable drug delivery device comprising particles and an osmotic pump |
| US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
| US7959938B2 (en) | 2005-03-15 | 2011-06-14 | Intarcia Therapeutics, Inc. | Polyoxaester suspending vehicles for use with implantable delivery systems |
| DE602007009377D1 (en) | 2006-05-30 | 2010-11-04 | Intarcia Therapeutics Inc | SECONDARY FLOW MODULATOR WITH AN INTERNAL CHANNEL FOR AN OSMOTIC OUTPUT SYSTEM |
| CN102274557B (en) | 2006-08-09 | 2014-12-03 | 精达制药公司 | Osmotic delivery systems and piston assemblies |
| DK2157967T3 (en) | 2007-04-23 | 2013-04-08 | Intarcia Therapeutics Inc | Suspension formulations of insulinotropic peptides and applications thereof |
| US8343140B2 (en) * | 2008-02-13 | 2013-01-01 | Intarcia Therapeutics, Inc. | Devices, formulations, and methods for delivery of multiple beneficial agents |
| NZ592113A (en) * | 2008-10-15 | 2012-04-27 | Intarcia Therapeutics Inc | Highly concentrated drug particles, formulations, suspensions and uses thereof |
| WO2010116304A1 (en) * | 2009-04-07 | 2010-10-14 | Koninklijke Philips Electronics N.V. | Valveless drug delivery device |
| LT2462246T (en) | 2009-09-28 | 2017-11-27 | Intarcia Therapeutics, Inc | Rapid establishment and/or termination of substantial steady-state drug delivery |
| US8882748B2 (en) | 2009-10-08 | 2014-11-11 | Palo Alto Research Center Incorporated | Transmucosal drug delivery device and method including chemical permeation enhancers |
| US9014799B2 (en) | 2009-10-08 | 2015-04-21 | Palo Alto Research Center Incorporated | Transmucosal drug delivery device and method including electrically-actuated permeation enhancement |
| US9017310B2 (en) | 2009-10-08 | 2015-04-28 | Palo Alto Research Center Incorporated | Transmucosal drug delivery device and method including microneedles |
| US20110301555A1 (en) * | 2010-06-03 | 2011-12-08 | Gonzalez-Zugasti Javier P | Porous matrix drug core for lacrimal insert device |
| US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
| KR101248035B1 (en) | 2011-08-25 | 2013-04-09 | 강성삼 | Safty brake system for automatic transmission car |
| US20130090633A1 (en) * | 2011-10-07 | 2013-04-11 | University Of Southern California | Osmotic patch pump |
| US9046085B2 (en) * | 2012-03-14 | 2015-06-02 | Eden Medical, Inc. | Miniature pumps |
| US9999720B2 (en) | 2012-09-27 | 2018-06-19 | Palo Alto Research Center Incorporated | Drug reconstitution and delivery device and methods |
| US9005108B2 (en) | 2012-09-27 | 2015-04-14 | Palo Alto Research Center Incorporated | Multiple reservoir drug delivery device and methods |
| US20140088345A1 (en) * | 2012-09-27 | 2014-03-27 | Palo Alto Research Center Incorporated | Single channel, multiple drug delivery device and methods |
| WO2014102741A2 (en) * | 2012-12-28 | 2014-07-03 | University Of The Witwatersrand, Johannesburg | Pharmaceutical dosage form |
| US9744341B2 (en) | 2013-01-15 | 2017-08-29 | Palo Alto Research Center Incorporated | Devices and methods for intraluminal retention and drug delivery |
| US9297083B2 (en) | 2013-12-16 | 2016-03-29 | Palo Alto Research Center Incorporated | Electrolytic gas generating devices, actuators, and methods |
| WO2015116646A1 (en) * | 2014-01-28 | 2015-08-06 | Mccoy Enterprises, Llc | Collagen permeated medical implants |
| US9801660B2 (en) | 2014-07-31 | 2017-10-31 | Palo Alto Research Center Incorporated | Implantable fluid delivery devices, systems, and methods |
| US10278675B2 (en) | 2014-07-31 | 2019-05-07 | Palo Alto Research Center Incorporated | Implantable estrus detection devices, systems, and methods |
| US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
| US9903503B2 (en) * | 2014-11-26 | 2018-02-27 | B/E Aerospace, Inc. | Aircraft water heating tank air vent valve |
| CN113598842A (en) | 2015-06-03 | 2021-11-05 | 因塔西亚制药公司 | Implant placement and removal system |
| IL258904B (en) | 2015-11-05 | 2022-09-01 | Massachusetts Gen Hospital | Intrathecal delivery of nucleic acid sequences encoding abcd1 for treatment of adrenomyeloneuropathy |
| EP3458084B1 (en) | 2016-05-16 | 2020-04-01 | Intarcia Therapeutics, Inc | Glucagon-receptor selective polypeptides and methods of use thereof |
| USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
| USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
| US10406336B2 (en) | 2016-08-03 | 2019-09-10 | Neil S. Davey | Adjustable rate drug delivery implantable device |
| CA3040906A1 (en) | 2016-10-20 | 2018-04-26 | Peptron, Inc. | Methods of delivering a neuroprotective polypeptide to the central nervous system |
| EP3565580B1 (en) | 2017-01-03 | 2024-03-06 | i2o Therapeutics, Inc. | Continuous administration of exenatide and co-adminstration of acetaminophen, ethinylestradiol or levonorgestrel |
| MX2019010651A (en) | 2017-03-08 | 2020-01-13 | Intarcia Therapeutics Inc | Apparatus and methods for administration of a nauseogenic compound from a drug delivery device. |
| USD933219S1 (en) | 2018-07-13 | 2021-10-12 | Intarcia Therapeutics, Inc. | Implant removal tool and assembly |
| CN113195524A (en) | 2018-10-11 | 2021-07-30 | 因塔西亚治疗公司 | Human amylin analog polypeptides and methods of use |
Family Cites Families (510)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR640907A (en) | 1927-06-25 | 1928-07-24 | Automatic flow limiter | |
| US2168437A (en) | 1935-04-10 | 1939-08-08 | Kenneth O Buercklin | Injection device |
| US2110208A (en) | 1937-02-12 | 1938-03-08 | U S Standard Products Company | Antigen preparations |
| US3025991A (en) | 1960-05-23 | 1962-03-20 | Carron Products Co | Bottle stopper |
| GB1049104A (en) | 1963-05-11 | 1966-11-23 | Prodotti Antibiotici Spa | Pharmaceutical compositions for oral or parenteral administration comprising tetracycline antibiotics |
| US3122162A (en) | 1963-06-20 | 1964-02-25 | Asa D Sands | Flow control device |
| US3632768A (en) | 1969-10-02 | 1972-01-04 | Upjohn Co | Therapeutic composition and method for treating infections with actinospectacin |
| US3625214A (en) | 1970-05-18 | 1971-12-07 | Alza Corp | Drug-delivery device |
| US3995631A (en) | 1971-01-13 | 1976-12-07 | Alza Corporation | Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient |
| US4034756A (en) | 1971-01-13 | 1977-07-12 | Alza Corporation | Osmotically driven fluid dispenser |
| US3732865A (en) | 1971-01-13 | 1973-05-15 | Alza Corp | Osmotic dispenser |
| US4211771A (en) | 1971-06-01 | 1980-07-08 | Robins Ronald K | Treatment of human viral diseases with 1-B-D-ribofuranosyl-1,2,4-triazole-3-carboxamide |
| BE795516A (en) | 1972-02-17 | 1973-08-16 | Ciba Geigy | PREPARATIONS OF OILY AND INJECTABLE PEPTIDES AND PROCESS FOR THEIR PREPARATION |
| US3797492A (en) | 1972-12-27 | 1974-03-19 | Alza Corp | Device for dispensing product with directional guidance member |
| US3995632A (en) | 1973-05-04 | 1976-12-07 | Alza Corporation | Osmotic dispenser |
| DE2528516A1 (en) | 1974-07-05 | 1976-01-22 | Sandoz Ag | NEW GALENIC PREPARATION |
| US3987790A (en) | 1975-10-01 | 1976-10-26 | Alza Corporation | Osmotically driven fluid dispenser |
| US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| US4078060A (en) | 1976-05-10 | 1978-03-07 | Richardson-Merrell Inc. | Method of inducing an estrogenic response |
| US4111202A (en) | 1976-11-22 | 1978-09-05 | Alza Corporation | Osmotic system for the controlled and delivery of agent over time |
| US4111201A (en) | 1976-11-22 | 1978-09-05 | Alza Corporation | Osmotic system for delivering selected beneficial agents having varying degrees of solubility |
| US4243030A (en) | 1978-08-18 | 1981-01-06 | Massachusetts Institute Of Technology | Implantable programmed microinfusion apparatus |
| US4305927A (en) | 1979-02-05 | 1981-12-15 | Alza Corporation | Method for the management of intraocular pressure |
| US4373527B1 (en) | 1979-04-27 | 1995-06-27 | Univ Johns Hopkins | Implantable programmable medication infusion system |
| US4310516A (en) | 1980-02-01 | 1982-01-12 | Block Drug Company Inc. | Cosmetic and pharmaceutical vehicle thickened with solid emulsifier |
| AU546785B2 (en) | 1980-07-23 | 1985-09-19 | Commonwealth Of Australia, The | Open-loop controlled infusion of diabetics |
| US4350271A (en) | 1980-08-22 | 1982-09-21 | Alza Corporation | Water absorbing fluid dispenser |
| US4376118A (en) | 1980-10-06 | 1983-03-08 | Miles Laboratories, Inc. | Stable nonaqueous solution of tetracycline salt |
| US4340054A (en) | 1980-12-29 | 1982-07-20 | Alza Corporation | Dispenser for delivering fluids and solids |
| US4455145A (en) | 1981-07-10 | 1984-06-19 | Alza Corporation | Dispensing device with internal drive |
| AU561343B2 (en) | 1981-10-19 | 1987-05-07 | Genentech Inc. | Human immune interferon by recombinant dna |
| EP0079143A3 (en) | 1981-10-20 | 1984-11-21 | Adnovum Ag | Pseudoplastic gel transfer |
| EP0080879B1 (en) | 1981-11-28 | 1986-10-01 | Sunstar Kabushiki Kaisha | Pharmaceutical composition containing interferon in stable state |
| US5004689A (en) | 1982-02-22 | 1991-04-02 | Biogen, Massachusetts | DNA sequences, recombinant DNA molecules and processes for producing human gamma interferon-like polypeptides in high yields |
| US4439196A (en) | 1982-03-18 | 1984-03-27 | Merck & Co., Inc. | Osmotic drug delivery system |
| US4455143A (en) | 1982-03-22 | 1984-06-19 | Alza Corporation | Osmotic device for dispensing two different medications |
| US6936694B1 (en) | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
| DE3220116A1 (en) | 1982-05-28 | 1983-12-01 | Dr. Karl Thomae Gmbh, 7950 Biberach | MICROBIOLOGICALLY MANUFACTURED (ALPHA) AND SS INTERFERONES, DNA SEQUENCES CODING FOR THESE INTERFERONES, MICROORGANISMS CONTAINING THIS GENETIC INFORMATION, AND METHOD FOR THE PRODUCTION THEREOF |
| US4753651A (en) | 1982-08-30 | 1988-06-28 | Alza Corporation | Self-driven pump |
| US4966843A (en) | 1982-11-01 | 1990-10-30 | Cetus Corporation | Expression of interferon genes in Chinese hamster ovary cells |
| US4552561A (en) | 1982-12-23 | 1985-11-12 | Alza Corporation | Body mounted pump housing and pump assembly employing the same |
| US4673405A (en) | 1983-03-04 | 1987-06-16 | Alza Corporation | Osmotic system with instant drug availability |
| US4639244A (en) | 1983-05-03 | 1987-01-27 | Nabil I. Rizk | Implantable electrophoretic pump for ionic drugs and associated methods |
| US4783337A (en) | 1983-05-11 | 1988-11-08 | Alza Corporation | Osmotic system comprising plurality of members for dispensing drug |
| US4765989A (en) | 1983-05-11 | 1988-08-23 | Alza Corporation | Osmotic device for administering certain drugs |
| DE3320583A1 (en) | 1983-06-08 | 1984-12-13 | Dr. Karl Thomae Gmbh, 7950 Biberach | NEW GALENIC PREPARATION FORMS OF ORAL ANTIDIABETICS AND METHOD FOR THE PRODUCTION THEREOF |
| JPS6058915A (en) | 1983-09-12 | 1985-04-05 | Fujisawa Pharmaceut Co Ltd | Lipid microcapsule preparation containing medicament |
| US4594108A (en) | 1983-09-19 | 1986-06-10 | The Dow Chemical Company | Highly pseudoplastic polymer solutions |
| US5385738A (en) | 1983-10-14 | 1995-01-31 | Sumitomo Pharmaceuticals Company, Ltd. | Sustained-release injection |
| MX9203641A (en) | 1983-12-16 | 1992-07-01 | Genentech Inc | RECOMBINANT GAMMA INTERFERONS THAT HAVE IMPROVED STABILITY AND BIOTECHNOLOGICAL METHODS FOR THEIR OBTAINING. |
| US4855238A (en) | 1983-12-16 | 1989-08-08 | Genentech, Inc. | Recombinant gamma interferons having enhanced stability and methods therefor |
| US4851228A (en) | 1984-06-20 | 1989-07-25 | Merck & Co., Inc. | Multiparticulate controlled porosity osmotic |
| US5120832A (en) | 1984-08-27 | 1992-06-09 | Genentech, Inc. | Distinct family of human leukocyte interferons |
| US5231176A (en) | 1984-08-27 | 1993-07-27 | Genentech, Inc. | Distinct family DNA encoding of human leukocyte interferons |
| US4927687A (en) | 1984-10-01 | 1990-05-22 | Biotek, Inc. | Sustained release transdermal drug delivery composition |
| US5411951A (en) | 1984-10-04 | 1995-05-02 | Monsanto Company | Prolonged release of biologically active somatotropin |
| IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
| FI90990C (en) | 1984-12-18 | 1994-04-25 | Boehringer Ingelheim Int | Recombinant DNA molecule, transformed host organism, and method for producing interferon |
| US4655462A (en) * | 1985-01-07 | 1987-04-07 | Peter J. Balsells | Canted coiled spring and seal |
| JPS61189230A (en) | 1985-02-19 | 1986-08-22 | Nippon Kayaku Co Ltd | Etoposide preparation |
| US4609374A (en) | 1985-04-22 | 1986-09-02 | Alza Corporation | Osmotic device comprising means for governing initial time of agent release therefrom |
| DE3685996T2 (en) | 1985-06-11 | 1993-01-14 | Ciba Geigy Ag | HYBRID INTERFERONE. |
| US4845196A (en) | 1985-06-24 | 1989-07-04 | G. D. Searle & Co. | Modified interferon gammas |
| US4847079A (en) | 1985-07-29 | 1989-07-11 | Schering Corporation | Biologically stable interferon compositions comprising thimerosal |
| DE3607835A1 (en) | 1986-03-10 | 1987-09-24 | Boehringer Ingelheim Int | HYBRID INTERFERONS, THEIR USE AS MEDICINAL PRODUCTS AND AS INTERMEDIATE PRODUCTS FOR THE PRODUCTION OF ANTIBODIES AND THE USE THEREOF AND METHOD FOR THEIR PRODUCTION |
| US4865845A (en) | 1986-03-21 | 1989-09-12 | Alza Corporation | Release rate adjustment of osmotic or diffusional delivery devices |
| US5118666A (en) | 1986-05-05 | 1992-06-02 | The General Hospital Corporation | Insulinotropic hormone |
| US5614492A (en) | 1986-05-05 | 1997-03-25 | The General Hospital Corporation | Insulinotropic hormone GLP-1 (7-36) and uses thereof |
| US6849708B1 (en) | 1986-05-05 | 2005-02-01 | The General Hospital Corporation | Insulinotropic hormone and uses thereof |
| US5120712A (en) | 1986-05-05 | 1992-06-09 | The General Hospital Corporation | Insulinotropic hormone |
| US7138486B2 (en) | 1986-05-05 | 2006-11-21 | The General Hospital Corporation | Insulinotropic hormone derivatives and uses thereof |
| US4755180A (en) | 1986-06-16 | 1988-07-05 | Alza Corporation | Dosage form comprising solubility regulating member |
| DE3636123A1 (en) | 1986-10-23 | 1988-05-05 | Rentschler Arzneimittel | ORAL ADMINISTRATIVE PREPARATIONS CONTAINING SINGLE DOSE FROM 10 TO 240 MG DIHYDROPYRIDINE |
| ZA878295B (en) | 1986-11-06 | 1988-05-03 | Amarillo Cell Culture Co. Inc. | Treatment of immuno-resistant disease |
| CA1320905C (en) | 1986-11-06 | 1993-08-03 | Joseph M. Cummins | Treatment of immuno-resistant disease |
| DE3642096A1 (en) | 1986-12-10 | 1988-06-16 | Boehringer Ingelheim Int | HORSE (GAMMA) INTERFERON |
| US5371089A (en) | 1987-02-26 | 1994-12-06 | Senetek, Plc | Method and composition for ameliorating the adverse effects of aging |
| US5278151A (en) | 1987-04-02 | 1994-01-11 | Ocular Research Of Boston, Inc. | Dry eye treatment solution |
| JPH0720866B2 (en) | 1987-05-15 | 1995-03-08 | 三生製薬株式会社 | Transdermal preparation containing eperisone or tolperisone or their salts |
| US4940465A (en) | 1987-05-27 | 1990-07-10 | Felix Theeuwes | Dispenser comprising displaceable matrix with solid state properties |
| US4892778A (en) | 1987-05-27 | 1990-01-09 | Alza Corporation | Juxtaposed laminated arrangement |
| US5938654A (en) | 1987-06-25 | 1999-08-17 | Alza Corporation | Osmotic device for delayed delivery of agent |
| US5023088A (en) | 1987-06-25 | 1991-06-11 | Alza Corporation | Multi-unit delivery system |
| US4874388A (en) | 1987-06-25 | 1989-10-17 | Alza Corporation | Multi-layer delivery system |
| US4915949A (en) | 1987-07-13 | 1990-04-10 | Alza Corporation | Dispenser with movable matrix comprising a plurality of tiny pills |
| US4915954A (en) | 1987-09-03 | 1990-04-10 | Alza Corporation | Dosage form for delivering a drug at two different rates |
| US5756450A (en) | 1987-09-15 | 1998-05-26 | Novartis Corporation | Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients and novel cyclosporin galenic forms |
| US4886668A (en) | 1987-09-24 | 1989-12-12 | Merck & Co., Inc. | Multiparticulate controlled porosity osmotic pump |
| US4917895A (en) | 1987-11-02 | 1990-04-17 | Alza Corporation | Transdermal drug delivery device |
| JPH0740268Y2 (en) * | 1988-04-07 | 1995-09-13 | 株式会社東海理化電機製作所 | Sliding contact switch |
| US4830344A (en) * | 1988-04-25 | 1989-05-16 | Peter J. Balsells | Canted-coil spring with turn angle and seal |
| US4934666A (en) * | 1988-04-25 | 1990-06-19 | Peter J. Balsells | Coiled spring electromagnetic shielding gasket |
| US4915366A (en) * | 1988-04-25 | 1990-04-10 | Peter J. Balsells | Outside back angle canted coil spring |
| US4826144A (en) * | 1988-04-25 | 1989-05-02 | Peter J. Balsells | Inside back angle canted coil spring |
| US4974821A (en) * | 1988-04-25 | 1990-12-04 | Peter J. Balsells | Canted-coil spring with major axis radial loading |
| US5203849A (en) * | 1990-03-20 | 1993-04-20 | Balsells Peter J | Canted coil spring in length filled with an elastomer |
| US5160122A (en) * | 1990-03-20 | 1992-11-03 | Peter J. Balsells | Coil spring with an elastomer having a hollow coil cross section |
| US4876781A (en) * | 1988-04-25 | 1989-10-31 | Peter J. Balsells | Method of making a garter-type axially resilient coiled spring |
| US4964204A (en) * | 1988-04-25 | 1990-10-23 | Peter J. Balsells | Method for making a garter-type axially-resilient coil spring |
| US4961253A (en) * | 1988-04-25 | 1990-10-09 | Peter J. Balsells | Manufacturing method for canted-coil spring with turn angle and seal |
| US4907788A (en) * | 1988-04-25 | 1990-03-13 | Peter J. Balsells | Dual concentric canted-coil spring apparatus |
| US5117066A (en) * | 1988-04-25 | 1992-05-26 | Peter J. Balsells | Retaining and locking electromagnetic gasket |
| US4893795A (en) | 1988-08-15 | 1990-01-16 | Peter J. Balsells | Radially loaded canted coiled spring with turn angle |
| US5072070A (en) * | 1989-12-01 | 1991-12-10 | Peter J. Balsells | Device for sealing electromagnetic waves |
| US5079388A (en) * | 1989-12-01 | 1992-01-07 | Peter J. Balsells | Gasket for sealing electromagnetic waves |
| EP0339544B1 (en) * | 1988-04-25 | 1993-09-22 | Peter J. Balsells | Garter spring with canted back angle located on outside diameter |
| US5108078A (en) * | 1988-04-25 | 1992-04-28 | Peter J. Balsells | Canted-coil spring loaded while in a cavity |
| US5024842A (en) | 1988-04-28 | 1991-06-18 | Alza Corporation | Annealed coats |
| US5160743A (en) | 1988-04-28 | 1992-11-03 | Alza Corporation | Annealed composition for pharmaceutically acceptable drug |
| US5006346A (en) | 1988-04-28 | 1991-04-09 | Alza Corporation | Delivery system |
| US4931285A (en) | 1988-04-28 | 1990-06-05 | Alza Corporation | Aqueous based pharmaceutical coating composition for dosage forms |
| JP2794022B2 (en) | 1988-11-11 | 1998-09-03 | 三生製薬株式会社 | Transdermal preparation containing bunazosin or its salts |
| US5728088A (en) | 1988-12-13 | 1998-03-17 | Alza Corporation | Osmotic system for delivery of fluid-sensitive somatotropins to bovine animals |
| US5034229A (en) | 1988-12-13 | 1991-07-23 | Alza Corporation | Dispenser for increasing feed conversion of hog |
| US5057318A (en) | 1988-12-13 | 1991-10-15 | Alza Corporation | Delivery system for beneficial agent over a broad range of rates |
| US5110596A (en) | 1988-12-13 | 1992-05-05 | Alza Corporation | Delivery system comprising means for delivering agent to livestock |
| US5059423A (en) | 1988-12-13 | 1991-10-22 | Alza Corporation | Delivery system comprising biocompatible beneficial agent formulation |
| US4969884A (en) | 1988-12-28 | 1990-11-13 | Alza Corporation | Osmotically driven syringe |
| US5234424A (en) | 1988-12-28 | 1993-08-10 | Alza Corporation | Osmotically driven syringe |
| US4976966A (en) | 1988-12-29 | 1990-12-11 | Alza Corporation | Delayed release osmotically driven fluid dispenser |
| US5288479A (en) | 1989-01-17 | 1994-02-22 | Sterling Drug, Inc. | Extrudable elastic oral pharmaceutical gel compositions and metered dose dispensers containing them and method of making and method of use thereof |
| US5705363A (en) | 1989-03-02 | 1998-01-06 | The Women's Research Institute | Recombinant production of human interferon τ polypeptides and nucleic acids |
| US5906816A (en) | 1995-03-16 | 1999-05-25 | University Of Florida | Method for treatment of autoimmune diseases |
| US5219572A (en) | 1989-03-17 | 1993-06-15 | Pitman-Moore, Inc. | Controlled release delivery device for macromolecular proteins |
| US5133974A (en) | 1989-05-05 | 1992-07-28 | Kv Pharmaceutical Company | Extended release pharmaceutical formulations |
| US5126142A (en) | 1989-07-18 | 1992-06-30 | Alza Corporation | Dispenser comprising ionophore |
| US5112614A (en) | 1989-09-14 | 1992-05-12 | Alza Corporation | Implantable delivery dispenser |
| US5290558A (en) | 1989-09-21 | 1994-03-01 | Osteotech, Inc. | Flowable demineralized bone powder composition and its use in bone repair |
| SE465950B (en) | 1989-10-23 | 1991-11-25 | Medinvent Sa | Combination of an aggregate particle size, crystalline or freeze-dried drug with a pseudoplastic gel for preparation of an injectable preparation as well as a process for its preparation |
| ES2046039T3 (en) | 1989-11-13 | 1994-01-16 | Becton Dickinson France | STORAGE BOTTLE CONTAINING A COMPONENT OF A MEDICINAL SOLUTION. |
| JPH03236317A (en) | 1989-12-06 | 1991-10-22 | Sansei Seiyaku Kk | Dopamine derivative-containing percutaneous |
| US5030216A (en) | 1989-12-15 | 1991-07-09 | Alza Corporation | Osmotically driven syringe |
| US5733572A (en) | 1989-12-22 | 1998-03-31 | Imarx Pharmaceutical Corp. | Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles |
| US5223266A (en) | 1990-01-24 | 1993-06-29 | Alza Corporation | Long-term delivery device with early startup |
| US5545618A (en) | 1990-01-24 | 1996-08-13 | Buckley; Douglas I. | GLP-1 analogs useful for diabetes treatment |
| US5213809A (en) | 1990-01-24 | 1993-05-25 | Alza Corporation | Delivery system comprising means for controlling internal pressure |
| US5122128A (en) | 1990-03-15 | 1992-06-16 | Alza Corporation | Orifice insert for a ruminal bolus |
| US5120306A (en) | 1990-03-21 | 1992-06-09 | Gosselin Leon F | Direct delivery of anti-inflammatories to the proximal small bowel |
| US5207752A (en) | 1990-03-30 | 1993-05-04 | Alza Corporation | Iontophoretic drug delivery system with two-stage delivery profile |
| US5324280A (en) * | 1990-04-02 | 1994-06-28 | Alza Corporation | Osmotic dosage system for delivering a formulation comprising liquid carrier and drug |
| US5091188A (en) | 1990-04-26 | 1992-02-25 | Haynes Duncan H | Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs |
| US5290271A (en) | 1990-05-14 | 1994-03-01 | Jernberg Gary R | Surgical implant and method for controlled release of chemotherapeutic agents |
| US5374620A (en) | 1990-06-07 | 1994-12-20 | Genentech, Inc. | Growth-promoting composition and its use |
| US5180591A (en) | 1990-07-11 | 1993-01-19 | Alza Corporation | Delivery device with a protective sleeve |
| US5234693A (en) | 1990-07-11 | 1993-08-10 | Alza Corporation | Delivery device with a protective sleeve |
| US5234692A (en) | 1990-07-11 | 1993-08-10 | Alza Corporation | Delivery device with a protective sleeve |
| US5234695A (en) | 1990-07-24 | 1993-08-10 | Eastman Kodak Company | Water dispersible vitamin E composition |
| US5300302A (en) | 1990-10-04 | 1994-04-05 | Nestec S.A. | Pharmaceutical composition in gel form in a dispensing package |
| US5529914A (en) | 1990-10-15 | 1996-06-25 | The Board Of Regents The Univeristy Of Texas System | Gels for encapsulation of biological materials |
| US5151093A (en) | 1990-10-29 | 1992-09-29 | Alza Corporation | Osmotically driven syringe with programmable agent delivery |
| IT1243390B (en) | 1990-11-22 | 1994-06-10 | Vectorpharma Int | PHARMACEUTICAL COMPOSITIONS IN THE FORM OF PARTICLES SUITABLE FOR THE CONTROLLED RELEASE OF PHARMACOLOGICALLY ACTIVE SUBSTANCES AND PROCEDURE FOR THEIR PREPARATION. |
| US5161806A (en) * | 1990-12-17 | 1992-11-10 | Peter J. Balsells | Spring-loaded, hollow, elliptical ring seal |
| GB9027422D0 (en) | 1990-12-18 | 1991-02-06 | Scras | Osmotically driven infusion device |
| IE920040A1 (en) | 1991-01-09 | 1992-07-15 | Alza Corp | Bioerodible devices and compositions for diffusional release¹of agents |
| US5443459A (en) | 1991-01-30 | 1995-08-22 | Alza Corporation | Osmotic device for delayed delivery of agent |
| US5861166A (en) | 1991-03-12 | 1999-01-19 | Alza Corporation | Delivery device providing beneficial agent stability |
| US5113938A (en) | 1991-05-07 | 1992-05-19 | Clayton Charley H | Whipstock |
| US5137727A (en) | 1991-06-12 | 1992-08-11 | Alza Corporation | Delivery device providing beneficial agent stability |
| EP0520119A1 (en) | 1991-06-17 | 1992-12-30 | Spirig Ag Pharmazeutische Präparate | New oral diclofenac composition |
| US5252338A (en) | 1991-06-27 | 1993-10-12 | Alza Corporation | Therapy delayed |
| US5190765A (en) | 1991-06-27 | 1993-03-02 | Alza Corporation | Therapy delayed |
| US5288214A (en) | 1991-09-30 | 1994-02-22 | Toshio Fukuda | Micropump |
| YU87892A (en) | 1991-10-01 | 1995-12-04 | Eli Lilly And Company Lilly Corporate Center | INJECTIBLE LONG TERM RELEASE FORMULATIONS AND PROCEDURES FOR THEIR OBTAINING AND USE |
| NZ244682A (en) | 1991-10-10 | 1993-12-23 | Alza Corp | Osmotically driven controlled delivery device characterised in that a |
| US5318780A (en) | 1991-10-30 | 1994-06-07 | Mediventures Inc. | Medical uses of in situ formed gels |
| US5236707A (en) | 1991-11-08 | 1993-08-17 | Dallas Biotherapeutics, Inc. | Stabilization of human interferon |
| WO1993009763A1 (en) | 1991-11-15 | 1993-05-27 | Isp Investments Inc. | Pharmaceutical tablet with pvp having an enhanced drug dissolution rate |
| DE4137649C2 (en) | 1991-11-15 | 1997-11-20 | Gerhard Dingler | Component |
| US5200195A (en) | 1991-12-06 | 1993-04-06 | Alza Corporation | Process for improving dosage form delivery kinetics |
| US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| US5223265A (en) | 1992-01-10 | 1993-06-29 | Alza Corporation | Osmotic device with delayed activation of drug delivery |
| US5676942A (en) | 1992-02-10 | 1997-10-14 | Interferon Sciences, Inc. | Composition containing human alpha interferon species proteins and method for use thereof |
| US5308348A (en) | 1992-02-18 | 1994-05-03 | Alza Corporation | Delivery devices with pulsatile effect |
| US5209746A (en) | 1992-02-18 | 1993-05-11 | Alza Corporation | Osmotically driven delivery devices with pulsatile effect |
| US5456679A (en) | 1992-02-18 | 1995-10-10 | Alza Corporation | Delivery devices with pulsatile effect |
| US5573934A (en) | 1992-04-20 | 1996-11-12 | Board Of Regents, The University Of Texas System | Gels for encapsulation of biological materials |
| US5221278A (en) | 1992-03-12 | 1993-06-22 | Alza Corporation | Osmotically driven delivery device with expandable orifice for pulsatile delivery effect |
| MX9301821A (en) | 1992-03-30 | 1994-03-31 | Alza Corp | BIODEGRADABLE POLYMERICAL MATRIX SYSTEM DEGRADATION REGULATOR AND METHOD OF TREATMENT OF THE SAME. |
| US5540912A (en) | 1992-03-30 | 1996-07-30 | Alza Corporation | Viscous suspensions of controlled-release drug particles |
| US6197346B1 (en) | 1992-04-24 | 2001-03-06 | Brown Universtiy Research Foundation | Bioadhesive microspheres and their use as drug delivery and imaging systems |
| FR2690622B1 (en) | 1992-04-29 | 1995-01-20 | Chronotec | Programmable ambulatory infusion pump system. |
| US5314685A (en) | 1992-05-11 | 1994-05-24 | Agouron Pharmaceuticals, Inc. | Anhydrous formulations for administering lipophilic agents |
| US5711968A (en) | 1994-07-25 | 1998-01-27 | Alkermes Controlled Therapeutics, Inc. | Composition and method for the controlled release of metal cation-stabilized interferon |
| US5413672A (en) | 1992-07-22 | 1995-05-09 | Ngk Insulators, Ltd. | Method of etching sendust and method of pattern-etching sendust and chromium films |
| US5512293A (en) | 1992-07-23 | 1996-04-30 | Alza Corporation | Oral sustained release drug delivery device |
| US5609885A (en) | 1992-09-15 | 1997-03-11 | Alza Corporation | Osmotic membrane and delivery device |
| GB9223146D0 (en) | 1992-11-05 | 1992-12-16 | Scherer Corp R P | Vented capsule |
| US5260069A (en) | 1992-11-27 | 1993-11-09 | Anda Sr Pharmaceuticals Inc. | Pulsatile particles drug delivery system |
| SE9203594D0 (en) | 1992-11-30 | 1992-11-30 | Christer Nystroem | DISPERSA SYSTEM MEDICINAL PRODUCT |
| US5368588A (en) | 1993-02-26 | 1994-11-29 | Bettinger; David S. | Parenteral fluid medication reservoir pump |
| WO1994021262A1 (en) | 1993-03-17 | 1994-09-29 | Alza Corporation | Device for the transdermal administration of alprazolam |
| US5514110A (en) | 1993-03-22 | 1996-05-07 | Teh; Eutiquio L. | Automatic flow control device |
| NZ250844A (en) | 1993-04-07 | 1996-03-26 | Pfizer | Treatment of non-insulin dependant diabetes with peptides; composition |
| US6284727B1 (en) | 1993-04-07 | 2001-09-04 | Scios, Inc. | Prolonged delivery of peptides |
| NZ247516A (en) | 1993-04-28 | 1995-02-24 | Bernard Charles Sherman | Water dispersible pharmaceutical compositions comprising drug dissolved in solvent system comprising at least one alcohol and at least one surfactant |
| US5424286A (en) | 1993-05-24 | 1995-06-13 | Eng; John | Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same |
| US5639477A (en) | 1993-06-23 | 1997-06-17 | Alza Corporation | Ruminal drug delivery device |
| AU7396294A (en) | 1993-06-25 | 1995-01-24 | Alza Corporation | Incorporating poly-n-vinyl amide in a transdermal system |
| US5498255A (en) | 1993-08-17 | 1996-03-12 | Alza Corporation | Osmotic device for protracted pulsatile delivery of agent |
| JP2700141B2 (en) | 1993-09-17 | 1998-01-19 | 富士化学工業株式会社 | Calcium hydrogen phosphate, its production method and excipient using the same |
| WO1995009007A1 (en) | 1993-09-29 | 1995-04-06 | Alza Corporation | Monoglyceride/lactate ester permeation enhancer for oxybutynin |
| US5540665A (en) | 1994-01-31 | 1996-07-30 | Alza Corporation | Gas driven dispensing device and gas generating engine therefor |
| CA2182576C (en) | 1994-02-04 | 2002-09-17 | Anders Carlsson | Bilayer preparations |
| US5697975A (en) | 1994-02-09 | 1997-12-16 | The University Of Iowa Research Foundation | Human cerebral cortex neural prosthetic for tinnitus |
| US5458888A (en) | 1994-03-02 | 1995-10-17 | Andrx Pharmaceuticals, Inc. | Controlled release tablet formulation |
| ATE227133T1 (en) | 1994-03-07 | 2002-11-15 | Imperial College | USE OF INTERFERON-ALPHA 8 SUBTYPE FOR PRODUCING MEDICATIONS FOR TREATING VIRAL INFECTIONS OF THE LIVER |
| ZA953078B (en) | 1994-04-28 | 1996-01-05 | Alza Corp | Effective therapy for epilepsies |
| AU682703B2 (en) | 1994-06-13 | 1997-10-16 | Alza Corporation | Dosage form for administering drug in liquid formulation |
| NL9401150A (en) | 1994-07-12 | 1996-02-01 | Nederland Ptt | Method for presenting on a receiving side a first number of video signals originating from a transmitting side, as well as a system, as well as a transmitter, as well as a network, and also a receiver. |
| WO1996002232A1 (en) | 1994-07-13 | 1996-02-01 | Alza Corporation | Composition and method for enhancing transdermal electrotransport agent delivery |
| US5633011A (en) | 1994-08-04 | 1997-05-27 | Alza Corporation | Progesterone replacement therapy |
| US5574008A (en) | 1994-08-30 | 1996-11-12 | Eli Lilly And Company | Biologically active fragments of glucagon-like insulinotropic peptide |
| US5512549A (en) | 1994-10-18 | 1996-04-30 | Eli Lilly And Company | Glucagon-like insulinotropic peptide analogs, compositions, and methods of use |
| US5595759A (en) | 1994-11-10 | 1997-01-21 | Alza Corporation | Process for providing therapeutic composition |
| DK0788351T3 (en) | 1994-11-10 | 2003-05-26 | Univ Kentucky Res Found | Implantable, refillable device for speed-controlled drug delivery directly to an internal part of the body |
| FR2731150B1 (en) | 1995-03-03 | 1997-04-18 | Oreal | USE OF AMPHIPHILIC COMPOUNDS AS A THICKENING AGENT FOR NON-AQUEOUS MEDIA |
| US6403655B1 (en) | 1995-03-06 | 2002-06-11 | Ethicon, Inc. | Method of preventing adhesions with absorbable polyoxaesters |
| US6100346A (en) | 1995-03-06 | 2000-08-08 | Ethicon, Inc. | Copolymers of polyoxaamides |
| US5698213A (en) | 1995-03-06 | 1997-12-16 | Ethicon, Inc. | Hydrogels of absorbable polyoxaesters |
| US5618552A (en) | 1995-03-06 | 1997-04-08 | Ethicon, Inc. | Absorbable polyoxaesters |
| US5464929A (en) | 1995-03-06 | 1995-11-07 | Ethicon, Inc. | Absorbable polyoxaesters |
| US5859150A (en) | 1995-03-06 | 1999-01-12 | Ethicon, Inc. | Prepolymers of absorbable polyoxaesters |
| US5648088A (en) | 1995-03-06 | 1997-07-15 | Ethicon, Inc. | Blends of absorbable polyoxaesters containing amines and/or amide groups |
| US5962023A (en) | 1995-03-06 | 1999-10-05 | Ethicon, Inc. | Hydrogels containing absorbable polyoxaamides |
| US6147168A (en) | 1995-03-06 | 2000-11-14 | Ethicon, Inc. | Copolymers of absorbable polyoxaesters |
| US5597579A (en) | 1995-03-06 | 1997-01-28 | Ethicon, Inc. | Blends of absorbable polyoxaamides |
| US5844017A (en) | 1995-03-06 | 1998-12-01 | Ethicon, Inc. | Prepolymers of absorbable polyoxaesters containing amines and/or amido groups |
| US5700583A (en) | 1995-03-06 | 1997-12-23 | Ethicon, Inc. | Hydrogels of absorbable polyoxaesters containing amines or amido groups |
| US5595751A (en) | 1995-03-06 | 1997-01-21 | Ethicon, Inc. | Absorbable polyoxaesters containing amines and/or amido groups |
| US5607687A (en) | 1995-03-06 | 1997-03-04 | Ethicon, Inc. | Polymer blends containing absorbable polyoxaesters |
| US5736159A (en) | 1995-04-28 | 1998-04-07 | Andrx Pharmaceuticals, Inc. | Controlled release formulation for water insoluble drugs in which a passageway is formed in situ |
| KR100404293B1 (en) | 1995-05-02 | 2004-02-18 | 다이쇼 세이야꾸 가부시끼가이샤 | Composition for Oral Administration |
| US5939286A (en) | 1995-05-10 | 1999-08-17 | University Of Florida | Hybrid interferon tau/alpha polypeptides, their recombinant production, and methods using them |
| US5882676A (en) | 1995-05-26 | 1999-03-16 | Alza Corporation | Skin permeation enhancer compositions using acyl lactylates |
| NZ311646A (en) | 1995-06-06 | 2000-02-28 | Hoffmann La Roche | Pharmaceutical composition comprising a proteinase inhibitor and a monoglyceride |
| US5690952A (en) | 1995-06-07 | 1997-11-25 | Judy A. Magruder et al. | Implantable system for delivery of fluid-sensitive agents to animals |
| US7833543B2 (en) | 1995-06-07 | 2010-11-16 | Durect Corporation | High viscosity liquid controlled delivery system and medical or surgical device |
| US5904935A (en) | 1995-06-07 | 1999-05-18 | Alza Corporation | Peptide/protein suspending formulations |
| US5747058A (en) | 1995-06-07 | 1998-05-05 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system |
| US6129761A (en) | 1995-06-07 | 2000-10-10 | Reprogenesis, Inc. | Injectable hydrogel compositions |
| US6572879B1 (en) | 1995-06-07 | 2003-06-03 | Alza Corporation | Formulations for transdermal delivery of pergolide |
| EP0836506B2 (en) | 1995-06-07 | 2011-12-21 | Ortho-McNeil Pharmaceutical, Inc. | Transdermal patch for administering 17-deacetyl norgestimate in combination with an estrogen |
| US5782396A (en) | 1995-08-28 | 1998-07-21 | United States Surgical Corporation | Surgical stapler |
| US5906830A (en) | 1995-09-08 | 1999-05-25 | Cygnus, Inc. | Supersaturated transdermal drug delivery systems, and methods for manufacturing the same |
| GB9521125D0 (en) | 1995-10-16 | 1995-12-20 | Unilever Plc | Cosmetic composition |
| US5766620A (en) | 1995-10-23 | 1998-06-16 | Theratech, Inc. | Buccal delivery of glucagon-like insulinotropic peptides |
| GB9521805D0 (en) | 1995-10-25 | 1996-01-03 | Cortecs Ltd | Solubilisation methods |
| ATE235505T1 (en) | 1995-10-30 | 2003-04-15 | Oleoyl Estrone Developments S | OLEAT MONOESTER OF ESTROGENS FOR THE TREATMENT OF OBESITY |
| US5908621A (en) | 1995-11-02 | 1999-06-01 | Schering Corporation | Polyethylene glycol modified interferon therapy |
| AUPN723395A0 (en) | 1995-12-19 | 1996-01-18 | Macnaught Medical Pty Limited | Lubrication methods |
| DE69734168T2 (en) * | 1996-02-02 | 2006-01-19 | Alza Corp., Mountain View | Implantable system with delayed release of active ingredient |
| US6156331A (en) * | 1996-02-02 | 2000-12-05 | Alza Corporation | Sustained delivery of an active agent using an implantable system |
| US6261584B1 (en) * | 1996-02-02 | 2001-07-17 | Alza Corporation | Sustained delivery of an active agent using an implantable system |
| WO1997028181A2 (en) | 1996-02-02 | 1997-08-07 | Rhomed Incorporated | Post-labeling stabilization of radiolabeled proteins and peptides |
| US6395292B2 (en) * | 1996-02-02 | 2002-05-28 | Alza Corporation | Sustained delivery of an active agent using an implantable system |
| US6132420A (en) * | 1996-02-02 | 2000-10-17 | Alza Corporation | Osmotic delivery system and method for enhancing start-up and performance of osmotic delivery systems |
| US5807876A (en) | 1996-04-23 | 1998-09-15 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme |
| US6124281A (en) | 1996-03-08 | 2000-09-26 | Zeneca Limited | Azolobenzazepine derivatives as neurologically active agents |
| JP2000506865A (en) | 1996-03-14 | 2000-06-06 | ジ イミューン リスポンス コーポレイション | Targeted delivery of genes encoding interferons |
| US5703200A (en) | 1996-03-15 | 1997-12-30 | Ethicon, Inc. | Absorbable copolymers and blends of 6,6-dialkyl-1,4-dioxepan-2-one and its cyclic dimer |
| US5660858A (en) | 1996-04-03 | 1997-08-26 | Research Triangle Pharmaceuticals | Cyclosporin emulsions |
| US6204022B1 (en) | 1996-04-12 | 2001-03-20 | Pepgen Corporation And University Of Florida | Low-toxicity human interferon-alpha analogs |
| US6074673A (en) | 1996-04-22 | 2000-06-13 | Guillen; Manuel | Slow-release, self-absorbing, drug delivery system |
| US5976109A (en) | 1996-04-30 | 1999-11-02 | Medtronic, Inc. | Apparatus for drug infusion implanted within a living body |
| DK0915910T3 (en) | 1996-06-05 | 2006-05-22 | Roche Diagnostics Gmbh | Exendin analogues, processes for their preparation, and drugs containing them |
| WO1997046204A2 (en) | 1996-06-05 | 1997-12-11 | Ashmont Holdings Limited | Injectable compositions |
| DE29610419U1 (en) | 1996-06-14 | 1996-10-24 | Filtertek Sa | Gravity infusion device for medical infusions |
| GB9613858D0 (en) | 1996-07-02 | 1996-09-04 | Cortecs Ltd | Hydrophobic preparations |
| US5916582A (en) | 1996-07-03 | 1999-06-29 | Alza Corporation | Aqueous formulations of peptides |
| US5932547A (en) | 1996-07-03 | 1999-08-03 | Alza Corporation | Non-aqueous polar aprotic peptide formulations |
| SK284490B6 (en) | 1996-07-03 | 2005-05-05 | Alza Corporation | Stable non-aqueous formulation and method for its preparation |
| ES2227707T3 (en) | 1996-07-15 | 2005-04-01 | Alza Corporation | NEW FORMULATIONS FOR THE TRANSDERMAL ADMINISTRATION OF FLUOXETINE ACETATE AND FLUOXETINE MALEATE. |
| AR008789A1 (en) | 1996-07-31 | 2000-02-23 | Bayer Corp | PIRIDINES AND SUBSTITUTED BIPHENYLS |
| ES2319936T5 (en) | 1996-08-08 | 2013-06-24 | Amylin Pharmaceuticals, Inc. | Regulation of gastrointestinal motility |
| US6268343B1 (en) | 1996-08-30 | 2001-07-31 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| US6458924B2 (en) | 1996-08-30 | 2002-10-01 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| IN184589B (en) | 1996-10-16 | 2000-09-09 | Alza Corp | |
| DK0934078T3 (en) | 1996-10-24 | 2003-04-14 | Alza Corp | Permeability promoters for transdermal administration of active substances, devices and processes for their preparation |
| US5817129A (en) | 1996-10-31 | 1998-10-06 | Ethicon, Inc. | Process and apparatus for coating surgical sutures |
| UA65549C2 (en) | 1996-11-05 | 2004-04-15 | Елі Ліллі Енд Компані | Use of glucagon-like peptides such as glp-1, glp-1 analog, or glp-1 derivative in methods and compositions for reducing body weight |
| DE19646392A1 (en) | 1996-11-11 | 1998-05-14 | Lohmann Therapie Syst Lts | Preparation for use in the oral cavity with a layer containing pressure-sensitive adhesive, pharmaceuticals or cosmetics for dosed delivery |
| US5928666A (en) | 1996-11-12 | 1999-07-27 | Cygnus Inc. | Crystalline form of estradiol and pharmaceutical formulations comprising same |
| ATE245042T1 (en) | 1996-11-15 | 2003-08-15 | Alza Corp | OSMOTIC DELIVERY SYSTEM AND METHOD FOR INCREASE PERFORMANCE AND IMPROVE THE INITIAL EFFECT OF OSMOTIC DELIVERY SYSTEMS |
| DE69705746T2 (en) | 1996-12-20 | 2001-10-31 | Alza Corp | INJECTABLE DEPOT GEL PREPARATION AND PRODUCTION METHOD |
| GB9626513D0 (en) | 1996-12-20 | 1997-02-05 | Bioglan Ireland R & D Ltd | A pharmaceutical composition |
| DK0996459T3 (en) | 1997-01-07 | 2006-01-16 | Amylin Pharmaceuticals Inc | Use of exendins and agonists thereof to reduce food intake |
| JP2001511128A (en) | 1997-01-28 | 2001-08-07 | ファルマシア・アンド・アップジョン・カンパニー | Lyophilized product of lipid complex of water-insoluble porphyrin |
| ZA981610B (en) | 1997-03-24 | 1999-08-26 | Alza Corp | Self adjustable exit port. |
| US5874388A (en) | 1997-04-02 | 1999-02-23 | Dow Corning Corporation | Lubricant composition for disc brake caliper pin and a disc brake asembly containing the lubricant |
| US6127520A (en) | 1997-04-15 | 2000-10-03 | Regents Of The University Of Michigan | Compositions and methods for the inhibition of neurotransmitter uptake of synaptic vesicles |
| WO1998047487A1 (en) | 1997-04-17 | 1998-10-29 | Dumex-Alpharma A/S | A novel bioadhesive drug delivery system based on liquid crystals |
| CA2288306A1 (en) * | 1997-04-28 | 1998-11-05 | Rhone-Poulenc Rorer S.A. | Adenovirus-mediated intratumoral delivery of an angiogenesis antagonist for the treatment of tumors |
| US20020039594A1 (en) | 1997-05-13 | 2002-04-04 | Evan C. Unger | Solid porous matrices and methods of making and using the same |
| US6663899B2 (en) | 1997-06-13 | 2003-12-16 | Genentech, Inc. | Controlled release microencapsulated NGF formulation |
| SI9700186B (en) | 1997-07-14 | 2006-10-31 | Lek, Tovarna Farmacevtskih In Kemicnih Izdelkov, D.D. | Novel pharmaceutical preparation with controlled release of active healing substances |
| MY125849A (en) * | 1997-07-25 | 2006-08-30 | Alza Corp | Osmotic delivery system, osmotic delivery system semipermeable body assembly, and method for controlling delivery rate of beneficial agents from osmotic delivery systems |
| MY125870A (en) * | 1997-07-25 | 2006-08-30 | Alza Corp | Osmotic delivery system flow modulator apparatus and method |
| US7157555B1 (en) | 1997-08-08 | 2007-01-02 | Amylin Pharmaceuticals, Inc. | Exendin agonist compounds |
| US6172046B1 (en) | 1997-09-21 | 2001-01-09 | Schering Corporation | Combination therapy for eradicating detectable HCV-RNA in patients having chronic Hepatitis C infection |
| JPH11100353A (en) | 1997-09-29 | 1999-04-13 | Esupo Kk | Refined and deodorized liquid ester wax and its composition |
| EP1019021B2 (en) | 1997-09-29 | 2012-12-26 | Novartis AG | Stabilized preparations for use in metered dose inhalers |
| US6133429A (en) | 1997-10-03 | 2000-10-17 | Becton Dickinson And Company | Chromophores useful for the preparation of novel tandem conjugates |
| ATE383867T1 (en) | 1997-11-14 | 2008-02-15 | Amylin Pharmaceuticals Inc | NOVEL EXENDIN AGONISTS |
| IL136326A0 (en) | 1997-12-08 | 2001-05-20 | Genentech Inc | Human interferon-epsilon: a type i interferon |
| US6368612B1 (en) | 1997-12-12 | 2002-04-09 | Biohybrid Technologies Llc | Devices for cloaking transplanted cells |
| JP4215188B2 (en) * | 1997-12-22 | 2009-01-28 | インターシア セラピューティクス，インコーポレイティド | Rate-regulating membranes for devices that regulate drug delivery |
| ES2216340T3 (en) | 1997-12-29 | 2004-10-16 | Alza Corporation | IMPLANTING DEVICE FOR SUBCUTANEOUS IMPLANTS. |
| DE69822208T2 (en) * | 1997-12-29 | 2005-04-28 | Alza Corp., Mountain View | OSMOTIC ADMINISTRATION SYSTEM WITH PUSHROOM RESTRAINT MECHANISM |
| CA2316886C (en) | 1997-12-30 | 2007-09-25 | Alza Corporation | Beneficial agent delivery system with membrane plug |
| US20040024068A1 (en) | 1998-01-23 | 2004-02-05 | Trustees Of Tufts College | Antimicrobial compounds |
| IT1298575B1 (en) | 1998-02-06 | 2000-01-12 | Vectorpharma Int | PHARMACEUTICAL COMPOSITIONS IN THE FORM OF NANOPARTICLES INCLUDING LIPID SUBSTANCES AND ANTIPHILIC SUBSTANCES AND RELATED PROCESS OF |
| US6017545A (en) | 1998-02-10 | 2000-01-25 | Modi; Pankaj | Mixed micellar delivery system and method of preparation |
| US6703359B1 (en) | 1998-02-13 | 2004-03-09 | Amylin Pharmaceuticals, Inc. | Inotropic and diuretic effects of exendin and GLP-1 |
| DE69936446T2 (en) | 1998-02-13 | 2008-03-06 | Amylin Pharmaceuticals, Inc., San Diego | INOTROPIC AND DIETIC EFFECTS OF EXENDIN AND GLP-1 |
| US6224577B1 (en) | 1998-03-02 | 2001-05-01 | Medrad, Inc. | Syringes and plungers for use therein |
| US6245357B1 (en) | 1998-03-06 | 2001-06-12 | Alza Corporation | Extended release dosage form |
| US6183461B1 (en) | 1998-03-11 | 2001-02-06 | Situs Corporation | Method for delivering a medication |
| US20020136848A1 (en) | 1998-03-12 | 2002-09-26 | Fumio Yoshii | Lactone-containing resin composition, molded object thereof, and film |
| US6029361A (en) | 1998-03-25 | 2000-02-29 | Ultratech Stepper, Inc. | Air-guage nozzle probe structure for microlithographic image focusing |
| US6074660A (en) | 1998-04-20 | 2000-06-13 | Ethicon, Inc. | Absorbable polyoxaesters containing amines and/ or amido groups |
| TW586944B (en) | 1998-05-29 | 2004-05-11 | Sumitomo Pharma | Controlled release agent having a multi-layer structure |
| DK1083924T3 (en) | 1998-06-12 | 2004-11-22 | Amylin Pharmaceuticals Inc | Glucagon-like peptide-1 (GLP-1) enhances beta cell response to glucose in individuals with impaired glucose tolerance |
| US6472512B1 (en) | 1998-07-21 | 2002-10-29 | Human Genome Sciences, Inc. | Keratinocyte derived interferon |
| US7390637B2 (en) | 1998-07-21 | 2008-06-24 | Human Genome Sciences, Inc. | Keratinocyte derived interferon |
| US6720407B1 (en) | 1998-08-28 | 2004-04-13 | Eli Lilly And Company | Method for administering insulinotropic peptides |
| US6551613B1 (en) | 1998-09-08 | 2003-04-22 | Alza Corporation | Dosage form comprising therapeutic formulation |
| US6174547B1 (en) | 1999-07-14 | 2001-01-16 | Alza Corporation | Dosage form comprising liquid formulation |
| JP2002524407A (en) | 1998-09-09 | 2002-08-06 | アルザ・コーポレーション | Dosage forms comprising liquid formulations |
| US6248112B1 (en) | 1998-09-30 | 2001-06-19 | C. R. Bard, Inc. | Implant delivery system |
| US6284725B1 (en) | 1998-10-08 | 2001-09-04 | Bionebraska, Inc. | Metabolic intervention with GLP-1 to improve the function of ischemic and reperfused tissue |
| WO2000025753A2 (en) | 1998-11-02 | 2000-05-11 | Alza Corporation | Controlled delivery of active agents |
| AU1623300A (en) | 1998-11-13 | 2000-06-05 | Sensor Technologies, Inc. | Monodisperse preparations useful with implanted devices |
| US20030060425A1 (en) | 1998-11-24 | 2003-03-27 | Ahlem Clarence N. | Immune modulation method using steroid compounds |
| NZ511931A (en) | 1998-12-07 | 2004-01-30 | Sod Conseils Rech Applic | Analogues of glucagon like peptide-1 |
| WO2000035419A2 (en) | 1998-12-17 | 2000-06-22 | Alza Corporation | Conversion of liquid filled gelatin capsules into controlled release systems by multiple coatings |
| WO2000038652A1 (en) | 1998-12-23 | 2000-07-06 | Amgen Inc. | Polyol/oil suspensions for the sustained release of proteins |
| PT1140014E (en) * | 1998-12-31 | 2003-07-31 | Alza Corp | OSMOTICAL DISTRIBUTION SYSTEM THAT HAS BOTTLE WITH EFFECTIVE USE OF SPACE |
| US6433144B1 (en) | 1999-01-12 | 2002-08-13 | Viragen, Inc. | Compositions of highly-purified natural mixtures of type I Interferon derived from leukocytes and methods |
| WO2000039280A2 (en) | 1998-12-31 | 2000-07-06 | Viragen, Inc. | Leukocyte-derived interferon preparations |
| WO2000040273A2 (en) | 1999-01-08 | 2000-07-13 | Vical Incorporated | Treatment of viral diseases using an interferon omega expressing polynucleotide |
| US6703225B1 (en) | 1999-01-12 | 2004-03-09 | Sumitomo Pharmaceuticals Company, Limited | Interferon-α |
| EP1658856B1 (en) | 1999-01-14 | 2010-03-17 | Amylin Pharmaceuticals, Inc. | Exendins for glucagon suppression |
| US7399489B2 (en) | 1999-01-14 | 2008-07-15 | Amylin Pharmaceuticals, Inc. | Exendin analog formulations |
| DE122007000001I1 (en) | 1999-01-14 | 2007-06-28 | Amylin Pharmaceuticals Inc | New exendin agonist formulations and their administration |
| IL144755A0 (en) | 1999-02-08 | 2002-06-30 | Alza Corp | Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles |
| US7258869B1 (en) | 1999-02-08 | 2007-08-21 | Alza Corporation | Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle |
| US7919109B2 (en) | 1999-02-08 | 2011-04-05 | Intarcia Therapeutics, Inc. | Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles |
| US6451974B1 (en) | 1999-03-17 | 2002-09-17 | Novo Nordisk A/S | Method of acylating peptides and novel acylating agents |
| US6541021B1 (en) | 1999-03-18 | 2003-04-01 | Durect Corporation | Devices and methods for pain management |
| US6835194B2 (en) | 1999-03-18 | 2004-12-28 | Durect Corporation | Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners |
| GB9907658D0 (en) | 1999-04-06 | 1999-05-26 | Zeneca Ltd | Chemical compounds |
| CN1355708A (en) | 1999-04-19 | 2002-06-26 | 先灵公司 | HCV combination therapy containing ribavirin in association with antioxidants |
| US6924264B1 (en) | 1999-04-30 | 2005-08-02 | Amylin Pharmaceuticals, Inc. | Modified exendins and exendin agonists |
| US6887470B1 (en) | 1999-09-10 | 2005-05-03 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
| EA003922B1 (en) | 1999-05-17 | 2003-10-30 | Конджачем, Инк. | Long lasting insulinotropic peptides |
| US6849714B1 (en) | 1999-05-17 | 2005-02-01 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
| US6514500B1 (en) | 1999-10-15 | 2003-02-04 | Conjuchem, Inc. | Long lasting synthetic glucagon like peptide {GLP-!} |
| US6506724B1 (en) | 1999-06-01 | 2003-01-14 | Amylin Pharmaceuticals, Inc. | Use of exendins and agonists thereof for the treatment of gestational diabetes mellitus |
| KR100844295B1 (en) | 1999-06-04 | 2008-07-07 | 알자 코포레이션 | Implantable gel compositions and method of manufacture |
| US20030059376A1 (en) | 1999-06-04 | 2003-03-27 | Libbey Miles A. | Formulations comprising dehydrated particles of pharmaceutical agents and process for preparing the same |
| AU5936400A (en) | 1999-06-04 | 2000-12-28 | Delrx Pharmaceutical Corporation | Formulations comprising dehydrated particles of pharmaceutical agents and process for preparing the same |
| US6833256B1 (en) | 1999-06-22 | 2004-12-21 | University Of Maryland | Interferon tau mutants and methods for making them |
| US6528486B1 (en) | 1999-07-12 | 2003-03-04 | Zealand Pharma A/S | Peptide agonists of GLP-1 activity |
| US6436091B1 (en) | 1999-11-16 | 2002-08-20 | Microsolutions, Inc. | Methods and implantable devices and systems for long term delivery of a pharmaceutical agent |
| US7022674B2 (en) | 1999-12-16 | 2006-04-04 | Eli Lilly And Company | Polypeptide compositions with improved stability |
| WO2001043528A2 (en) | 1999-12-17 | 2001-06-21 | Durect Corporation | Devices and methods in intracerebrospinal delivery of morphine-6-glucuronide |
| ES2248156T3 (en) * | 1999-12-21 | 2006-03-16 | Alza Corporation | VALVE FOR OSMOTIC DEVICES. |
| US6283949B1 (en) | 1999-12-27 | 2001-09-04 | Advanced Cardiovascular Systems, Inc. | Refillable implantable drug delivery pump |
| US6572890B2 (en) | 2000-01-13 | 2003-06-03 | Osmotica Corp. | Osmotic device containing venlafaxine and an anti-psychotic agent |
| US6472060B1 (en) | 2000-01-19 | 2002-10-29 | Seco Tools Ab | Coated body with nanocrystalline CVD coating for enhanced edge toughness and reduced friction |
| US6844321B2 (en) | 2000-01-31 | 2005-01-18 | Novo Nordisk A/S | Crystallization of a GLP-1 analogue |
| US6465425B1 (en) | 2000-02-10 | 2002-10-15 | Alkermes Controlled Therapeutics, Inc. | Microencapsulation and sustained release of biologically active acid-stable or free sulfhydryl-containing proteins |
| US6471688B1 (en) | 2000-02-15 | 2002-10-29 | Microsolutions, Inc. | Osmotic pump drug delivery systems and methods |
| US6464688B1 (en) | 2000-02-15 | 2002-10-15 | Microsolutions, Inc. | Osmotic pump delivery system with flexible drug compartment |
| CN1487836A (en) | 2000-03-14 | 2004-04-07 | 埃米林药品公司 | Effects of glucagon-like peptide-1 (7-36) on antro-pyloro-duodenal motility |
| US20030211974A1 (en) | 2000-03-21 | 2003-11-13 | Brodbeck Kevin J. | Gel composition and methods |
| US6992065B2 (en) | 2000-04-19 | 2006-01-31 | Genentech, Inc. | Sustained release formulations |
| EP1278551A2 (en) | 2000-04-21 | 2003-01-29 | Vical Incorporated | Compositions and methods for (in vivo) delivery of polynucleotide-based therapeutics |
| JP2001357075A (en) | 2000-04-27 | 2001-12-26 | El-Con System Co Ltd | System and method for calculating quantity of materials while utilizing two-dimensional cad interface |
| KR100518046B1 (en) | 2000-05-19 | 2005-10-04 | 아밀린 파마슈티칼스, 인크. | Treatment of acute coronary syndrome with glp-1 |
| US6495164B1 (en) | 2000-05-25 | 2002-12-17 | Alkermes Controlled Therapeutics, Inc. I | Preparation of injectable suspensions having improved injectability |
| HU229208B1 (en) | 2000-06-16 | 2013-09-30 | Lilly Co Eli | Glucagon-like peptide-1 analogs |
| US6479065B2 (en) | 2000-08-10 | 2002-11-12 | Alkermes Controlled Therapeutics, Inc. | Process for the preparation of polymer-based sustained release compositions |
| US6824822B2 (en) | 2001-08-31 | 2004-11-30 | Alkermes Controlled Therapeutics Inc. Ii | Residual solvent extraction method and microparticles produced thereby |
| CA2423431A1 (en) | 2000-10-06 | 2002-04-11 | Durect Corporation | Devices and methods for management of inflammation |
| IL155730A0 (en) | 2000-11-03 | 2003-11-23 | Biomedicines Inc | Method for short-term and long-term drug dosimetry |
| WO2002067895A2 (en) | 2000-11-16 | 2002-09-06 | Durect Corporation | Implant dosage form and use thereof for the delivery of a cholesterol lowering agent |
| US20050070883A1 (en) | 2000-11-29 | 2005-03-31 | Brown James E | Devices and methods for controlled delivery from a drug delivery device |
| US20020165286A1 (en) | 2000-12-08 | 2002-11-07 | Hanne Hedeman | Dermal anti-inflammatory composition |
| WO2002048192A2 (en) | 2000-12-13 | 2002-06-20 | Eli Lilly And Company | Amidated glucagon-like peptide-1 |
| MXPA03005135A (en) | 2000-12-13 | 2003-12-04 | Lilly Co Eli | Chronic treatment regimen using glucagon-like insulinotropic peptides. |
| MXPA03005388A (en) | 2000-12-14 | 2003-09-25 | Amylin Pharmaceuticals Inc | Peptide yy and peptide yy agonists for treatment of metabolic disorders. |
| IN188924B (en) | 2001-03-01 | 2002-11-23 | Bharat Serums & Vaccines Ltd | |
| CA2440387A1 (en) | 2001-03-23 | 2002-10-03 | Durect Corporation | Delivery of drugs from sustained release devices implanted in myocardial tissue or in the pericardial space |
| US6632217B2 (en) | 2001-04-19 | 2003-10-14 | Microsolutions, Inc. | Implantable osmotic pump |
| JP2005506956A (en) | 2001-06-01 | 2005-03-10 | イーライ・リリー・アンド・カンパニー | Long-acting GLP-1 formulation |
| US6514517B2 (en) | 2001-06-20 | 2003-02-04 | Ethicon, Inc. | Antimicrobial coatings for medical devices |
| AU2002320122B2 (en) | 2001-06-21 | 2007-07-26 | Genentech, Inc. | Sustained release formulation |
| US7163688B2 (en) | 2001-06-22 | 2007-01-16 | Alza Corporation | Osmotic implant with membrane and membrane retention means |
| WO2003000294A1 (en) | 2001-06-22 | 2003-01-03 | Pfizer Products Inc. | Pharmaceutical compositions containing a solid dispersion of a poorly-soluble drug in a matrix and a solubility-enhancing polymer |
| US20030138403A1 (en) | 2001-06-29 | 2003-07-24 | Maxygen Aps | Interferon formulations |
| CA2455963C (en) | 2001-07-31 | 2017-07-04 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Glp-1, exendin-4, peptide analogs and uses thereof |
| HUP0501192A3 (en) | 2001-08-23 | 2006-06-28 | Lilly Co Eli | Glucagon-like peptide-1 analogs |
| GB0121709D0 (en) | 2001-09-07 | 2001-10-31 | Imp College Innovations Ltd | Food inhibition agent |
| EP1424957A2 (en) | 2001-09-14 | 2004-06-09 | Francis J. Martin | Microfabricated nanopore device for sustained release of therapeutic agent |
| DE60233811D1 (en) | 2001-09-17 | 2009-11-05 | Durect Corp | DEVICE AND METHOD FOR THE ACCURATE DELIVERY OF AN ACTIVE SUBSTANCE |
| DK1499277T3 (en) | 2001-09-24 | 2009-05-11 | Imp Innovations Ltd | PYY-36 for reducing or preventing obesity |
| US7041646B2 (en) | 2001-10-05 | 2006-05-09 | Bayer Pharmaceuticals Corporation | Methods of treating type 2 diabetes with peptides acting as both GLP-1 receptor agonists and glucagon receptor antagonists |
| CA2460690A1 (en) | 2001-10-05 | 2003-04-17 | Intermune, Inc. | Method of treating hepatitis virus infection with a multiphasic interferon delivery profile |
| CN100438870C (en) | 2001-11-09 | 2008-12-03 | 精达制药公司 | Method for treating diseases with omega interferon |
| IL162000A0 (en) | 2001-11-14 | 2005-11-20 | Alza Corp | Injectable depot compositions and use thereof |
| NZ533434A (en) | 2001-11-14 | 2006-11-30 | Alza Corp | Thixotropic gel composition for injectable deposition |
| ATE502621T1 (en) | 2001-11-14 | 2011-04-15 | Durect Corp | CATHETER INJECTABLE DEPOSIT COMPOSITIONS AND USE THEREOF |
| US20030108608A1 (en) | 2001-12-12 | 2003-06-12 | Erik Laridon | Thermoplastic articles comprising silver-containing antimicrobials and high amounts of carboxylic acid salts for increased surface-available silver |
| EP1463751B1 (en) | 2001-12-21 | 2013-05-22 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US8058233B2 (en) | 2002-01-10 | 2011-11-15 | Oregon Health And Science University | Modification of feeding behavior using PYY and GLP-1 |
| US7105489B2 (en) | 2002-01-22 | 2006-09-12 | Amylin Pharmaceuticals, Inc. | Methods and compositions for treating polycystic ovary syndrome |
| GB2386066A (en) | 2002-02-28 | 2003-09-10 | Norbrook Lab Ltd | Long-acting parasiticidal composition with improved bioavailability comprising a salicylanilide, a further anti-parasitic compound & a polymeric species |
| GB0204722D0 (en) | 2002-02-28 | 2002-04-17 | Norferm Da | Method |
| EP1572915A4 (en) | 2002-04-11 | 2011-01-05 | Medimmune Vaccines Inc | Preservation of bioactive materials by spray drying |
| DE60315474T2 (en) * | 2002-06-17 | 2008-04-24 | Alza Corp., Mountain View | OSMOTIC DISTRIBUTION SYSTEMS WITH OSMOTIC DRIVE AND METHOD FOR PRODUCING BOTH THE OSMOTIC DRIVE AND THE OSMOTIC DELIVERY SYSTEM |
| US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
| DE60317225T2 (en) * | 2002-06-26 | 2008-05-29 | Intarcia Therapeutics, Inc., Emeryville | MINIMALLY ADVANCED VOLUME-EFFICIENT PISTON FOR OSMOTIC DRUG DISPENSING SYSTEMS |
| US7177526B2 (en) | 2002-06-28 | 2007-02-13 | Intel Corporation | System and method for improving audio during post-production of video recordings |
| NZ537955A (en) | 2002-07-31 | 2007-10-26 | Alza Corp | Injectable depot compositions and uses thereof |
| DK1539101T3 (en) | 2002-07-31 | 2009-04-27 | Alza Corp | Injectable, multi-modal polymeric compositions and applications thereof |
| US20080260838A1 (en) | 2003-08-01 | 2008-10-23 | Mannkind Corporation | Glucagon-like peptide 1 (glp-1) pharmaceutical formulations |
| KR20050074492A (en) | 2002-10-22 | 2005-07-18 | 와라타 파마수티컬즈, 인크. | Treatment of diabetes |
| KR20050088288A (en) | 2002-11-06 | 2005-09-05 | 알자 코포레이션 | Controlled release depot formulations |
| US6969702B2 (en) | 2002-11-20 | 2005-11-29 | Neuronova Ab | Compounds and methods for increasing neurogenesis |
| US7014636B2 (en) | 2002-11-21 | 2006-03-21 | Alza Corporation | Osmotic delivery device having a two-way valve and a dynamically self-adjusting flow channel |
| US7790681B2 (en) | 2002-12-17 | 2010-09-07 | Amylin Pharmaceuticals, Inc. | Treatment of cardiac arrhythmias with GLP-1 receptor ligands |
| US7731947B2 (en) | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
| US20040224903A1 (en) | 2002-12-19 | 2004-11-11 | Stephen Berry | Stable, non-aqueous, single-phase gels and formulations thereof for delivery from an implantable device |
| GB0300571D0 (en) | 2003-01-10 | 2003-02-12 | Imp College Innovations Ltd | Modification of feeding behaviour |
| JP2004238392A (en) | 2003-01-14 | 2004-08-26 | Nipro Corp | Stabilized proteinic preparation |
| CA2520775A1 (en) | 2003-03-31 | 2004-10-21 | Alza Corporation | Non-aqueous single phase vehicles and formulations utilizing such vehicles |
| AR043810A1 (en) | 2003-03-31 | 2005-08-17 | Alza Corp | OSMOTIC SYSTEM OF ADMINISTRATION AND METHOD TO DECREASE TIMES OF ARRIVAL IN THE OPERATING REGIME IN OSMOTIC SYSTEMS OF ADMINISTRATION |
| JP2006521897A (en) * | 2003-03-31 | 2006-09-28 | アルザ・コーポレーション | Osmotic pump with means for dissipating internal pressure |
| EP1626752A2 (en) | 2003-05-16 | 2006-02-22 | Blue Membranes GmbH | Medical implants comprising biocompatible coatings |
| CN1822816A (en) | 2003-05-30 | 2006-08-23 | 阿尔萨公司 | Implantable elastomeric depot compositions and uses thereof |
| WO2005000222A2 (en) | 2003-05-30 | 2005-01-06 | Amylin Pharmaceuticals, Inc. | Novel methods and compositions for enhanced transmucosal delivery of peptides and proteins |
| CN102940879B (en) | 2003-06-03 | 2017-06-06 | 诺沃挪第克公司 | Stabilized pharmaceutical peptide compositions |
| US8491571B2 (en) | 2003-06-12 | 2013-07-23 | Cordis Corporation | Orifice device having multiple channels with varying flow rates for drug delivery |
| US7205409B2 (en) | 2003-09-04 | 2007-04-17 | Abbott Laboratories | Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) |
| WO2005032524A2 (en) | 2003-09-30 | 2005-04-14 | Alza Corporation | Osmotically driven active agent delivery device providing an ascending release profile |
| PL380763A1 (en) | 2003-10-31 | 2007-03-05 | Alza Corporation | Osmotic pump with self-retaining, fast-start membrane plug |
| CN1874763A (en) | 2003-11-06 | 2006-12-06 | 阿尔扎公司 | Modular imbibition rate reducer for use with implantable osmotic pump |
| US20050118206A1 (en) | 2003-11-14 | 2005-06-02 | Luk Andrew S. | Surfactant-based gel as an injectable, sustained drug delivery vehicle |
| US20050106214A1 (en) | 2003-11-14 | 2005-05-19 | Guohua Chen | Excipients in drug delivery vehicles |
| US20050281879A1 (en) | 2003-11-14 | 2005-12-22 | Guohua Chen | Excipients in drug delivery vehicles |
| US7780973B2 (en) | 2003-12-15 | 2010-08-24 | Ethicon Endo-Surgery, Inc. | Method and device for minimally invasive implantation of biomaterial |
| US20050175701A1 (en) * | 2004-02-10 | 2005-08-11 | Alza Corporation | Capillary moderator for osmotic delivery system |
| US8076288B2 (en) | 2004-02-11 | 2011-12-13 | Amylin Pharmaceuticals, Inc. | Hybrid polypeptides having glucose lowering activity |
| US20060094652A1 (en) | 2004-02-11 | 2006-05-04 | Levy Odile E | Hybrid polypeptides with selectable properties |
| US7456254B2 (en) | 2004-04-15 | 2008-11-25 | Alkermes, Inc. | Polymer-based sustained release device |
| US8617613B2 (en) | 2004-04-15 | 2013-12-31 | Alkermes Pharma Ireland Limited | Polymer-based sustained release device |
| US20050266087A1 (en) | 2004-05-25 | 2005-12-01 | Gunjan Junnarkar | Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium |
| US20090042781A1 (en) | 2004-06-28 | 2009-02-12 | Novo Nordisk A/S | Methods for Treating Diabetes |
| US7772182B2 (en) | 2004-08-05 | 2010-08-10 | Alza Corporation | Stable suspension formulations of erythropoietin receptor agonists |
| GB2434189B (en) | 2004-08-18 | 2009-04-01 | Waters Investments Ltd | Defined leak path for high pressure seal |
| US8268791B2 (en) | 2004-08-25 | 2012-09-18 | Aegis Therapeutics, Llc. | Alkylglycoside compositions for drug administration |
| US20080038316A1 (en) | 2004-10-01 | 2008-02-14 | Wong Vernon G | Conveniently implantable sustained release drug compositions |
| US7442682B2 (en) | 2004-10-19 | 2008-10-28 | Nitto Denko Corporation | Transepithelial delivery of peptides with incretin hormone activities |
| US8394765B2 (en) | 2004-11-01 | 2013-03-12 | Amylin Pharmaceuticals Llc | Methods of treating obesity with two different anti-obesity agents |
| CN101094689B (en) | 2004-11-01 | 2013-06-12 | 安米林药品有限责任公司 | Methods of treating obesity and obesity-related diseases and disorders |
| US20060142234A1 (en) | 2004-12-23 | 2006-06-29 | Guohua Chen | Injectable non-aqueous suspension |
| US20060141040A1 (en) | 2004-12-23 | 2006-06-29 | Guohua Chen | Injectable non-aqueous suspension |
| WO2006074051A2 (en) | 2004-12-30 | 2006-07-13 | Diakine Therapeutics, Inc. | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR RESTORING β-CELL MASS AND FUNCTION |
| EP1843783B1 (en) | 2005-01-25 | 2012-05-30 | MicroCHIPS, Inc. | Control of drug release by transient modification of local microenvironments |
| EP2361630A1 (en) | 2005-02-03 | 2011-08-31 | Intarcia Therapeutics, Inc | Implantable drug delivery device comprising particles and an osmotic pump |
| US20060216242A1 (en) * | 2005-02-03 | 2006-09-28 | Rohloff Catherine M | Suspending vehicles and pharmaceutical suspensions for drug dosage forms |
| WO2006083761A2 (en) | 2005-02-03 | 2006-08-10 | Alza Corporation | Solvent/polymer solutions as suspension vehicles |
| US8263545B2 (en) | 2005-02-11 | 2012-09-11 | Amylin Pharmaceuticals, Inc. | GIP analog and hybrid polypeptides with selectable properties |
| US7959938B2 (en) | 2005-03-15 | 2011-06-14 | Intarcia Therapeutics, Inc. | Polyoxaester suspending vehicles for use with implantable delivery systems |
| EP1871403B1 (en) | 2005-03-31 | 2010-09-08 | Amylin Pharmaceuticals, Inc. | Compositions and methods for the control, prevention and treatment of eating disorders |
| EP1909824B1 (en) | 2005-04-08 | 2011-05-18 | Amylin Pharmaceuticals, Inc. | Pharmaceutical formulations comprising incretin peptide and aprotic polar solvent |
| US20090305964A1 (en) | 2005-04-21 | 2009-12-10 | Gastrotech Pharma A/S | Pharmaceutical preparations of a glp-1 molecule and an anti-emetic drug |
| US7686787B2 (en) | 2005-05-06 | 2010-03-30 | Medtronic Minimed, Inc. | Infusion device and method with disposable portion |
| US20060280795A1 (en) | 2005-06-08 | 2006-12-14 | Dexcel Pharma Technologies, Ltd. | Specific time-delayed burst profile delivery system |
| US20070027105A1 (en) | 2005-07-26 | 2007-02-01 | Alza Corporation | Peroxide removal from drug delivery vehicle |
| EP1922336B1 (en) | 2005-08-11 | 2012-11-21 | Amylin Pharmaceuticals, LLC | Hybrid polypeptides with selectable properties |
| MX2008002370A (en) | 2005-08-19 | 2008-04-29 | Amylin Pharmaceuticals Inc | Exendin for treating diabetes and reducing body weight. |
| US8389472B2 (en) | 2005-08-19 | 2013-03-05 | Amylin Pharmaceuticals, Llc | Exendin-4 to treat nonalcoholic steatohepatitis and nonalcoholic fatty liver disease |
| HUE029798T2 (en) | 2005-11-04 | 2017-03-28 | Glaxosmithkline Llc | Methods for administering hypoglycemic agents |
| JP5096363B2 (en) | 2005-12-16 | 2012-12-12 | ネクター セラピューティックス | GLP-1 polymer complex |
| CA2634016A1 (en) | 2005-12-16 | 2007-07-05 | Amylin Pharmaceuticals, Inc. | Compositions and methods for treating obesity and related metabolic disorders |
| EP1984009B1 (en) | 2006-01-18 | 2012-10-24 | Qps, Llc | Pharmaceutical compositions with enhanced stability |
| AU2007227202B2 (en) | 2006-03-21 | 2013-08-22 | Amylin Pharmaceuticals, Llc | Peptide-peptidase inhibitor conjugates and methods of using same |
| EP3255149A3 (en) | 2006-05-02 | 2018-04-18 | Intrexon Actobiotics NV | Microbial intestinal delivery of obesity related peptides |
| US8299024B2 (en) | 2006-05-12 | 2012-10-30 | Amylin Pharmaceuticals, Llc | Methods to restore glycemic control |
| DE602007009377D1 (en) | 2006-05-30 | 2010-11-04 | Intarcia Therapeutics Inc | SECONDARY FLOW MODULATOR WITH AN INTERNAL CHANNEL FOR AN OSMOTIC OUTPUT SYSTEM |
| GB0613196D0 (en) | 2006-07-03 | 2006-08-09 | Imp Innovations Ltd | Novel compounds and their effects on feeding behaviour |
| WO2008019147A2 (en) | 2006-08-04 | 2008-02-14 | Amylin Pharmaceuticals, Inc. | Use of exendins, exendin agonists and glp-1 receptor agonists for altering the concentration of fibrinogen |
| CN102274557B (en) * | 2006-08-09 | 2014-12-03 | 精达制药公司 | Osmotic delivery systems and piston assemblies |
| WO2008061355A1 (en) | 2006-11-24 | 2008-05-29 | Matregen Corp. | Glp-1 depot systems, and methods of manufacture and uses thereof |
| TWI428346B (en) | 2006-12-13 | 2014-03-01 | Imp Innovations Ltd | Novel compounds and their effects on feeding behaviour |
| US20090022727A1 (en) | 2007-01-26 | 2009-01-22 | Alza Corp. | Injectable, nonaqueous suspension with high concentration of therapeutic agent |
| DK2157967T3 (en) | 2007-04-23 | 2013-04-08 | Intarcia Therapeutics Inc | Suspension formulations of insulinotropic peptides and applications thereof |
| WO2008134425A1 (en) | 2007-04-27 | 2008-11-06 | Cedars-Sinai Medical Center | Use of glp-1 receptor agonists for the treatment of gastrointestinal disorders |
| CN102231981A (en) | 2008-02-08 | 2011-11-02 | 昌达生物科技公司 | Composition for sustained release delivery of proteins or peptides |
| US8343140B2 (en) * | 2008-02-13 | 2013-01-01 | Intarcia Therapeutics, Inc. | Devices, formulations, and methods for delivery of multiple beneficial agents |
| EP2254659B1 (en) | 2008-02-14 | 2017-06-14 | Enteromedics Inc. | Treatment of excess weight by neural downregulation in combination with compositions |
| EP2259791A2 (en) | 2008-03-05 | 2010-12-15 | Tel HaShomer Medical Research Infrastructure and Services Ltd. | Glp-1 receptor agonists and related active pharmaceutical ingredients for treatment of cancer |
| PT2343982T (en) | 2008-09-17 | 2017-07-04 | Chiasma Inc | Pharmaceutical compositions and related methods of delivery |
| NZ592113A (en) | 2008-10-15 | 2012-04-27 | Intarcia Therapeutics Inc | Highly concentrated drug particles, formulations, suspensions and uses thereof |
| LT2462246T (en) | 2009-09-28 | 2017-11-27 | Intarcia Therapeutics, Inc | Rapid establishment and/or termination of substantial steady-state drug delivery |
| JO2976B1 (en) | 2009-12-22 | 2016-03-15 | ايلي ليلي اند كومباني | Oxyntomodulin peptide analogue |
| US8263554B2 (en) | 2010-06-09 | 2012-09-11 | Amylin Pharmaceuticals, Inc. | Methods of using GLP-1 receptor agonists to treat pancreatitis |
| US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
-
2007
- 2007-05-30 DE DE602007009377T patent/DE602007009377D1/en active Active
- 2007-05-30 AT AT07797884T patent/ATE481963T1/en not_active IP Right Cessation
- 2007-05-30 JP JP2009513435A patent/JP5143131B2/en active Active
- 2007-05-30 NZ NZ572003A patent/NZ572003A/en unknown
- 2007-05-30 ES ES07797884T patent/ES2351527T3/en active Active
- 2007-05-30 US US11/755,494 patent/US8052996B2/en active Active
- 2007-05-30 CN CN2007800187567A patent/CN101453982B/en active Active
- 2007-05-30 KR KR1020087028256A patent/KR101106510B1/en active IP Right Grant
- 2007-05-30 AU AU2007266475A patent/AU2007266475B2/en active Active
- 2007-05-30 CA CA2651855A patent/CA2651855C/en active Active
- 2007-05-30 MX MX2008014870A patent/MX2008014870A/en active IP Right Grant
- 2007-05-30 WO PCT/US2007/069990 patent/WO2007140416A2/en active Application Filing
- 2007-05-30 EP EP07797884A patent/EP2020990B1/en active Active
- 2007-05-30 DK DK07797884.9T patent/DK2020990T3/en active
-
2008
- 2008-10-22 IL IL194746A patent/IL194746A/en active IP Right Grant
-
2009
- 2009-08-10 HK HK09107318.1A patent/HK1129203A1/en unknown
-
2011
- 2011-08-12 US US13/209,328 patent/US8158150B2/en active Active
-
2012
- 2012-03-29 US US13/433,287 patent/US8273365B2/en active Active
- 2012-08-31 US US13/601,939 patent/US8367095B2/en active Active
-
2013
- 2013-01-12 US US13/740,187 patent/US8470353B2/en active Active
- 2013-05-20 US US13/898,358 patent/US8992962B2/en active Active
-
2015
- 2015-02-26 US US14/632,700 patent/US9539200B2/en active Active
-
2016
- 2016-11-09 US US15/347,261 patent/US20170181964A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2651855A1 (en) | Two-piece, internal-channel osmotic delivery system flow modulator | |
| JP2008511410A5 (en) | ||
| EP1991290B1 (en) | Needleless access port valves | |
| USD614292S1 (en) | Culture swab | |
| JP2005530588A5 (en) | ||
| TW200531709A (en) | Minimally compliant, volume efficient piston for osmotic drug delivery systems | |
| JP2001510791A5 (en) | ||
| WO2002085428A3 (en) | Implantable osmotic pump | |
| WO2002074381A3 (en) | Implantable refillable and rate controlled drug delivery device | |
| WO2009031601A1 (en) | Cartridge tank for lubrication agent | |
| WO2009050614A3 (en) | Assembly for lubricating a portion of a medical device | |
| WO2009056991A3 (en) | Device for delivery of a foamable composition | |
| WO2005037350A3 (en) | Internal fluid connector for establishing a fluid connection | |
| EP2282092A3 (en) | Control valve having "C" seal | |
| CA2563579A1 (en) | In-can fuel cell metering valve | |
| EP2048322A3 (en) | An assembly for cutting into a well tubular | |
| AU2008224619B2 (en) | Pressure control valve assembly | |
| WO2004037326A3 (en) | Mixing and delivery medical syringe system for therapeutic compositions | |
| PL112318B1 (en) | Device for making injections into animal's body especially for artificial insemination of cattle | |
| JP4909623B2 (en) | Liquid supply tool | |
| US20200324258A1 (en) | Tattoo Ink Mixing Apparatus | |
| EP1736119A2 (en) | Voice prosthesis device | |
| NO20071039L (en) | Cartridge with multiple partitions for drug delivery device | |
| US20150025472A1 (en) | Cover for a syringe and method of making | |
| ES2349296T3 (en) | CARTRIDGE FOR A SQUEEZABLE MASS. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |