CA2626116A1 - Systems and method for endoscopic angle-resolved low coherence interferometry - Google Patents

Systems and method for endoscopic angle-resolved low coherence interferometry Download PDF

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CA2626116A1
CA2626116A1 CA002626116A CA2626116A CA2626116A1 CA 2626116 A1 CA2626116 A1 CA 2626116A1 CA 002626116 A CA002626116 A CA 002626116A CA 2626116 A CA2626116 A CA 2626116A CA 2626116 A1 CA2626116 A1 CA 2626116A1
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sample
resolved
angle
reflected
cross
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CA2626116C (en
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Adam Wax
John W. Pyhtila
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Duke University
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Adam Wax
John W. Pyhtila
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G01J3/4412—Scattering spectrometry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7253—Details of waveform analysis characterised by using transforms
    • A61B5/7257—Details of waveform analysis characterised by using transforms using Fourier transforms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00—Measuring instruments characterised by the use of optical techniques
    • G01B9/02—Interferometers
    • G01B9/02041—Interferometers characterised by particular imaging or detection techniques
    • G01B9/02044—Imaging in the frequency domain, e.g. by using a spectrometer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00—Measuring instruments characterised by the use of optical techniques
    • G01B9/02—Interferometers
    • G01B9/02083—Interferometers characterised by particular signal processing and presentation
    • G01B9/02084—Processing in the Fourier or frequency domain when not imaged in the frequency domain
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00—Measuring instruments characterised by the use of optical techniques
    • G01B9/02—Interferometers
    • G01B9/02083—Interferometers characterised by particular signal processing and presentation
    • G01B9/02087—Combining two or more images of the same region
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00—Measuring instruments characterised by the use of optical techniques
    • G01B9/02—Interferometers
    • G01B9/0209—Low-coherence interferometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/45—Interferometric spectrometry
    • G01J3/453—Interferometric spectrometry by correlation of the amplitudes
    • G01J3/4531—Devices without moving parts
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • A61B5/0066—Optical coherence imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N2021/4704—Angular selective
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N2021/4704—Angular selective
    • G01N2021/4709—Backscatter
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N2021/4735—Solid samples, e.g. paper, glass
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/08—Optical fibres; light guides

Abstract

Fourier domain a/LCI (faLCI) system and method which enables in vivo data acquisition at rapid rates using a single scan. Angle-resolved and depth-resolved spectra information is obtained with one scan. The reference arm can remain fixed with respect to the sample due to only one scan required. A
reference signal and a reflected sample signal are cross-correlated and dispersed at a multitude of reflected angles off of the sample, thereby representing reflections from a multitude of points on the sample at the same time in parallel. Information about all depths of the sample at each of the multitude of different points on the sample can be obtained with one scan on the order of approximately 40 milliseconds. From the spatial, cross-correlated reference signal, structural (size) information can also be obtained using techniques that allow size information of scatterers to be obtained from angle-resolved data.

Claims (58)

1. A method of obtaining depth-resolved spectra of a sample for determining depth characteristics of scatterers within the sample, comprising the steps of:
emitting a source beam onto a splitter, wherein the splitter is fixed with respect to the sample, and wherein the splitter splits light from the source beam to produce a reference beam and a sample beam;
directing the sample beam towards the sample at an angle;
receiving an angle-resolved reflected sample beam as a result of the sample beam reflectively scattering at a multitude of reflected angles off of the sample in parallel at the same time, wherein the angle-resolved reflected sample beam contains the angular scattering distribution of the reflected sample beam;
cross-correlating the angled-resolved reflected sample beam with the reference beam to produce an angle-resolved cross-correlated signal about the sample;
spectrally dispersing the angle-resolved cross-correlated signal to yield a single, angle-resolved, spectrally-resolved cross-correlation reflection profile having depth-resolved information about the sample at each of the multitude of reflected angles; and Fourier transforming of the angled-resolved cross-correlated signal to produce depth-resolved information about the sample as a function of angle and depth.
2. The method of claim 1, further comprising processing the angle-resolved cross-correlated signal to obtain depth-resolved information about the scatterers of the sample at a multitude of different points on the sample from the angle-resolved, spectrally-resolved cross-correlation reflection profile.
3. The method of claim 1, further comprising recovering size information about the scatterers from the angle-resolved, spectrally-resolved cross-correlation reflection profile.
4. The method of claim 3, wherein recovering the size information is obtained by comparing the angular scattering distribution of the sample to a predicted analytically or numerically calculated angular scattering distribution of the sample.
5. The method of claim 4, wherein the predicted analytically or numerically calculated angular scattering distribution of the sample is a Mie theory angular scattering distribution of the sample.
6. The method of claim 4, further comprising filtering the angular scattering distribution of the sample before the step of comparing.
7. The method of claim 4, further comprising calculating a Gaussian distribution of sizes of the scatterers by calculating a mean diameter and a standard deviation to model the angular scattering distribution of the sample.
8. The method of claim 1, further comprising the step of collimating the sample beam to produce a collimated sample beam, wherein the step of directing the sample beam towards the sample at an angle comprises directing the collimated sample beam towards the sample at an angle.
9. The method of claim 1, further comprising the step of collimating the reference beam to produce a collimated reference beam.
10. The method of claim 1, wherein the reference beam is reflected before the step of cross-correlating to create a reflected reference beam.
11. The method of claim 10, wherein the reflected reference beam is created by reflecting the reference beam off of a reference mirror.
12. The method of claim 1, wherein the splitter is an optical fiber splitter.
13. The method of claim 1, wherein the source beam is comprised of a light selected from the group consisting of a white light from an arc lamp, a thermal source, a LED, a coherent light from a broadband laser, a superluminescent diode, a diode laser, and a supercontinuum source.
14. The method of claim 1, wherein the step of cross-correlating the angle-resolved reflected sample beam with the reference beam comprises:
determining an interference term by measuring the intensity of the angle-resolved reflected sample beam and the reference beam independently; and subtracting the interference term from the total intensity of the angle-resolved reflected sample beam.
15. The method of claim 1, wherein the length of the path of the reference beam is fixed.
16. The method of claim 1, wherein the splitter is attached to a fixed reference arm.
17. The method of claim 1, wherein the sample is attached to a fixed sample arm.
18. The method of claim 1, wherein the step of spectrally dispersing the angle-resolved cross-correlated signal comprises directing the angle-resolved reflected sample beam which has been combined with the reference beam into a spectrograph.
19. The method of claim 18, wherein the spectrograph comprises an imaging spectrograph comprised of a plurality of imaging points wherein each of the plurality of imaging points corresponds to a specific scattering angle in order to produce the angle-resolved, spectrally-resolved cross-correlation reflection profile about the sample.
20. The method of claim 18, wherein the spectrograph comprises a multi-channel spectrograph comprised of a plurality of channels, wherein each of the plurality of channels corresponds to a specific scattering angle in order to produce the angle-resolved, spectrally-resolved cross-correlation reflection profile about the sample.
21. The method of claim 1, wherein the step of receiving the angle-resolved reflected sample beam as a result of the sample beam reflectively scattering at the multitude of reflected angles off of the sample in parallel at the same time comprises capturing the angular distribution of the reflected sample beam at an end of a fiber bundle comprised of a plurality of fibers.
22. The method of claim 21, wherein the plurality of fibers in the fiber bundle are arranged to collect different angular reflections of the reflected sample beam to collect the angular scattering distribution of the reflected sample beam.
23. The method of claim 21, wherein the fiber bundle comprises a linear array of single mode fibers.
24. The method of claim 21, further comprising the step of carrying the sample beam on a delivery fiber wherein the delivery fiber delivers the sample beam at an oblique angle with respect to the sample and the fiber bundle so that the specular reflection due to the sample is not received by the fiber bundle.
25. The method claim 21, further comprising the step of receiving the angle-resolved reflected sample beam via a Fourier transform property of an optical element placed in between the fiber-optic bundle and the sample to receive the angle-resolved reflected sample beam located at the other focus of the optical element.
26. The method of claim 21, wherein the plurality of fibers possess the same or substantially the same spatial arrangement at distal and proximal ends of the plurality of fibers so that the fiber bundle is spatially coherent with respect to conveying the angular distribution of the angle-resolved reflected sample beam.
27. The method of claim 1, further comprising the step of splitting more light at the splitter from the source beam to produce more light in the sample beam than in the reference beam.
28. The method of claim 25 wherein the optical element is either a lens or an imaging optical element.
29. An apparatus for obtaining depth-resolved spectra of a sample for determining size and depth characteristics of scatterers within a sample, comprising:
a receiver that is fixed with respect to the sample that:
receives an angle-resolved reflected sample beam to produce, via a Fourier transform, depth-resolved information about the sample as a function of angle and depth, created as a result of a sample beam, split by a splitter from a source beam, which is reflectively scattering at a multitude of reflected angles off of the sample, in parallel at the same time, wherein the angle-resolved reflected sample beam contains the angular scattering distribution of the angle-resolved reflected sample beam;
receives a reference beam split by the splitter from the source beam; and cross-correlates the angle-resolved reflected sample beam with the reference beam to produce an angle-resolved and depth-resolved cross-correlated signal about the sample;
a detector that spectrally disperses the angle-resolved and depth-resolved cross-correlated signal to yield a single, angle-resolved, spectrally-resolved cross-correlation reflection profile having depth-resolved information about the sample at each of the multitude of reflected angles; and a processor that receives the single, angle-resolved, spectrally-resolved cross-correlation reflection profile.
30. The apparatus of claim 29, wherein the processor is adapted to determine the depth of the scatterers of the sample at a multitude of different points on the sample from the single, angle-resolved, spectrally-resolved cross-correlation reflection profile.
31. The apparatus of claim 29, wherein the processor is adapted to recover size information about the scatterers from the angle-resolved, spectrally-resolved cross-correlation reflection profile.
32. The apparatus of claim 31, wherein the processor recovers the size information by comparing the angular scattering distribution of the sample to a predicted analytically or numerically calculated angular scattering distribution of the sample.
33. The apparatus of claim 32, wherein the predicted analytically or numerically calculated angular scattering distribution of the sample is a Mie theory angular scattering distribution of the sample.
34. The apparatus of claim 32, wherein the processor is further adapted to filter the angular scattering distribution of the sample before comparing the angular scattering distribution of the sample to a predicted analytically or numerically calculated angular scattering distribution of the sample.
35. The apparatus of claim 34, wherein the processor is further adapted to identify a Gaussian distribution of sizes of the scatterers by identifying a mean diameter and a standard deviation to model the angular scattering distribution.
36. The apparatus of claim 29, wherein the sample beam is collimated.
37. The apparatus of claim 29 wherein the reference beam is collimated.
38. The apparatus of claim 29, further comprising a reflection device to receive and reflect the reference beam wherein the receiver receives the reflected reference beam.
39. The apparatus of claim 38, wherein the reflection device is a reference mirror.
40. The apparatus of claim 29, wherein the splitter is an optical fiber splitter.
41. The apparatus of claim 29, wherein the source beam is comprised of a light selected from the group consisting of a white light from an arc lamp, a thermal source, a LED, a coherent light from a broadband laser, a superluminescent diode, a diode laser, and a supercontinuum source.
42. The apparatus of claim 29, wherein the length of the path of the reference beam is fixed.
43. The apparatus of claim 29, wherein the splitter is attached to a fixed reference arm.
44. The apparatus of claim 29, wherein the sample is attached to a fixed sample arm.
45. The apparatus of claim 29, further comprising a spectrograph that receives the angle-resolved reflected sample beam and the reference beam to produce the angle-resolved and depth-resolved cross-correlated signal about the sample.
46. The apparatus of claim 29, wherein the receiver is a fiber bundle comprised of a plurality of fibers.
47. The apparatus of claim 46, wherein the plurality of fibers in the fiber bundle are arranged to collect different angular reflections of the reflected sample beam to collect the angular scattering distribution of the angle-resolved reflected sample beam.
48. The apparatus of claim 46, wherein the fiber bundle comprises a linear array of single mode fibers.
49. The apparatus of claim 47, further comprising a delivery fiber that carries the sample beam so that the delivery fiber delivers the sample beam at an oblique angle with respect to the sample and the fiber bundle so that the specular reflection due to the sample is not received by the fiber bundle.
50. The apparatus of claim 47, wherein the plurality of fibers is positioned at one focus of an optical element to receive the angle-resolved reflected sample beam which is located at the other focus of the optical element such that the fiber bundle receives the angular distribution of scattered light via a Fourier transform property of the optical element.
51. The apparatus of claim 47, wherein the plurality of fibers possess the same or substantially the same spatial arrangement at distal and proximal ends of the plurality of fibers so that the fiber bundle is spatially coherent with respect to conveying the angular distribution of the angle-resolved reflected sample beam.
52. The apparatus of claim 29, wherein the splitter splits more light from the source beam to produce the source beam than to produce the reference beam.
53. The apparatus of claim 50 wherein the optical element is either a lens or an imaging optical element.
54. An apparatus for obtaining depth-resolved spectra of a sample for determining size and depth characteristics of scatterers within a sample, comprising:
a delivery fiber that carries a sample beam wherein the sample beam is directed to the sample over the delivery fiber and scattered at a multitude of reflected angles off of the sample to produce a scattered sample beam;
a fiber-optic bundle receiver comprised of a plurality of fibers positioned at one focus of an optical element to receive the scattered sample beam reflected by the sample which is located at the other focus of the optical element, such that the fiber-optic bundle receiver receives the angular distribution of the scattered sample beam via a Fourier transform property of the optical element.
a detector that spectrally disperses the scattered sample beam to yield an angle-resolved, spectrally-resolved reflection profile at each of the multitude of reflected angles in parallel at the same time; and a processor that receives and analyzes the angle-resolved, spectrally-resolved reflection profile.
55. The apparatus of claim 54, wherein the plurality of fibers in the fiber-optic bundle receiver are arranged to collect different angular reflections of the sample beam to collect the angular scattering distribution of the scattered sample beam.
56. The apparatus of claim 54, wherein the fiber-optic bundle receiver comprises a linear array of single mode fibers.
57. The apparatus of claim 54, wherein the plurality of fibers possess the same spatial arrangement at distal and proximal ends of the plurality of fibers so that the fiber-optic bundle receiver is spatially coherent with respect to conveying the angular scattering distribution of scattered sample beam.
58. The apparatus of claim 54 wherein the optical element is either a lens or an imaging optical element.
CA2626116A 2005-10-11 2006-10-11 Systems and method for endoscopic angle-resolved low coherence interferometry Expired - Fee Related CA2626116C (en)

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US72560305P 2005-10-11 2005-10-11
US60/725,603 2005-10-11
PCT/US2006/039771 WO2007044821A1 (en) 2005-10-11 2006-10-11 Systems and method for endoscopic angle-resolved low coherence interferometry

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