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Publication numberCA2568824 A1
Publication typeApplication
Application numberCA 2568824
Publication date14 Jun 2007
Filing date24 Nov 2006
Priority date14 Dec 2005
Also published asCA2568824C, CN1991368A, CN1991368B, DE602006003615D1, EP1798289A1, EP1798289B1, US7955484, US20070131549
Publication numberCA 2568824, CA 2568824 A1, CA 2568824A1, CA-A1-2568824, CA2568824 A1, CA2568824A1
InventorsXiaohua Cai, Chung Chang Young, Jianhong Pei, Andy Vo
ApplicantNova Biomedical Corporation, Xiaohua Cai, Chung Chang Young, Jianhong Pei, Andy Vo
Export CitationBiBTeX, EndNote, RefMan
External Links: CIPO, Espacenet
Glucose biosensor and method
CA 2568824 A1
Abstract
A system for more accurately measuring glucose in a sample includes a first glucose-sensing electrode incorporating a quantity of glucose oxidase, a second glucose-sensing electrode incorporating a quantity of PQQ-glucose dehydrogenase, a reference electrode, and means for selecting between a first glucose measurement made with the first glucose-sensing electrode and a second glucose measurement made with the second glucose-sensing electrode.
Description  available in
Claims(16)
1. A glucose biosensor comprising:
a laminated body having a fluid sample inlet end and an electrical contact end;
a fluid sample inlet;
a substantially flat sample chamber in communication between said fluid sample inlet and a vent opening, said test chamber being adapted to collect a fluid sample through said fluid sample inlet;
a GOD-based glucose electrode;
a GDH-based glucose electrode; and a reference electrode wherein said GOD-based glucose electrode, said GDH-based glucose electrode and said reference electrode are within said sample chamber.
2. The glucose biosensor of Claim 1 wherein said GOD-based glucose electrode further includes a redox mediator.
3. The glucose biosensor of Claim 2 wherein said GOD-based glucose electrode further includes one or more of a material selected from the group consisting of a binder, a buffer and a surfactant.
4. The glucose biosensor of Claim 1 wherein said GDH-based glucose electrode further includes a redox mediator.
5. The glucose biosensor of Claim 4 wherein said GDH-based glucose electrode further includes one or more of a material selected from the group consisting of a binder, a buffer and a surfactant.
6. A system for more accurately measuring glucose in a sample comprising:
a first glucose-sensing electrode incorporating a quantity of glucose oxidase;

a second glucose-sensing electrode incorporating a quantity of PQQ-glucose dehydrogenase;
a reference electrode; and means for selecting between a first glucose measurement made with said first glucose-sensing electrode and a second glucose measurement made with said second glucose-sensing electrode.
7. The system of Claim 6 wherein said first glucose-sensing electrode further includes a redox mediator.
8. The system of Claim 7 wherein said first glucose-sensing electrode further includes one or more of a material selected from the group consisting of a binder, a buffer and a surfactant.
9. The system of Claim 6 wherein said second glucose-sensing electrode further includes a redox mediator.
10. The system of Claim 9 wherein said first glucose-sensing electrode further includes one or more of a material selected from the group consisting of a binder, a buffer and a surfactant.
11. The system of Claim 6 wherein said selecting means includes a system capable of determining the difference between said first glucose measurement and said second glucose measurement and selecting one of said first glucose measurement and said second glucose measurement based on said difference when said difference is compared to a predefined value.
12. A method for determining glucose concentration in a blood sample more accurately, said method comprising:
making a first measurement of said glucose concentration of said blood sample using a glucose electrode incorporating glucose oxidase;

making a second measurement of said glucose concentration of said blood sample using a glucose electrode incorporating PQQ-glucose dehydrogenase;
calculating the difference between said first measurement and said second measurement; and selecting one of said first measurement and said second measurement based on said calculated difference.
13. The method of Claim 12 wherein said selecting step further includes selecting one of said first measurement and said second measurement based on said difference when said difference is compared to a predefined value.
14. The method of Claim 13 wherein said selecting step further includes selecting said first measurement if said calculated difference is greater than about 24 mg/dL.
15. The method of Claim 13 wherein said selecting step further includes selecting said second measurement if said calculated difference is less than or equal to about 24 mg/dL.
16. A disposable glucose sensor comprising:
a sensor body having an open well forming a test chamber;
a GOD-based glucose electrode, a GDH-based glucose electrode and reference/counter electrode disposed within said open well; and electrical contacts on one end of said sensor body.
Classifications
International ClassificationG01N27/416, G01N27/403, G01N27/327
Cooperative ClassificationG01N33/66, C12Q1/006
European ClassificationC12Q1/00B6B, G01N33/66
Legal Events
DateCodeEventDescription
24 Nov 2006EEERExamination request