CA2553633A1 - Fluid testing sensor having vents for directing fluid flow - Google Patents

Fluid testing sensor having vents for directing fluid flow Download PDF

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Publication number
CA2553633A1
CA2553633A1 CA002553633A CA2553633A CA2553633A1 CA 2553633 A1 CA2553633 A1 CA 2553633A1 CA 002553633 A CA002553633 A CA 002553633A CA 2553633 A CA2553633 A CA 2553633A CA 2553633 A1 CA2553633 A1 CA 2553633A1
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CA
Canada
Prior art keywords
sample
fluid
vent
sensor
vents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002553633A
Other languages
French (fr)
Other versions
CA2553633C (en
Inventor
Christina Blaschke
Daniel V. Brown
Sung-Kwon Jung
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Healthcare LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2553633A1 publication Critical patent/CA2553633A1/en
Application granted granted Critical
Publication of CA2553633C publication Critical patent/CA2553633C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502723—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0825—Test strips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces

Abstract

A sensor (10) for analyzing a fluid sample has a sample cavity (36) for accepting sample fluid. At least one test region (14) is disposed along the sample cavity (36), and at least one vent (26) fulfills the dual function of venting the sample cavity (36) and guiding the sample fluid (42) in the sample cavity (36) via appropriate location and geometry of at least one sample guide edge (44).

Claims (27)

1. A sensor for analysis of a fluid sample comprising:
a sample cavity for accepting sample fluid;
at least one test region disposed along said sample cavity; and at least one vent for venting said sample cavity, said at least one vent having at least one sample guide edge for guiding said sample fluid to said at least one test region.
2. The sensor of claim 1 having a plurality of vents having aligned sample guide edges for guiding said sample fluid toward said test region.
3. The sensor of claim 2 wherein two vents are square-shaped and wherein said test region is located between sample guide edges provided on separate zones of said two vents.
4. The sensor of claim 1 wherein said at least one vent comprises two staggered vents spaced from each other to form a fluid pathway within said sample cavity.
5. The sensor of claim 4 wherein said fluid pathway is a tortuous fluid pathway having at least one turn along which said sample fluid flows.
6. The sensor of claim 5 further comprising a reagent layer in communication with said sample cavity.
7. The sensor of claim 1 wherein said at least one vent comprises two vents being placed proximate to each other to form a bottleneck region for controlling a flow of said sample fluid.
8. The sensor of claim 1 wherein said at least one test region is selected from the group consisting of an electrode and a reagent area.
9. The sensor of claim 1 wherein said at least one test region comprises two electrodes.
10. The sensor of claim 9 further comprising a dielectric material covering edges of said two electrodes
11. A method for collecting sample fluid and positioning sample fluid in a test sensor for analysis of said sample fluid comprising:
accepting said sample fluid within a sample cavity via capillary action; and directing said sample fluid through said sample cavity toward at least one test region of said sensor using at least one sample guide edge provided on at least one vent venting said sample cavity.
12. The method of claim 11 wherein accepting said sample fluid comprises accepting said sample fluid at a fluid inlet area.
13. The method of claim 11 wherein said at least one test region is selected from the group consisting of an electrode and a reagent area.
14. The method of claim 11 wherein said at least one test region comprises two electrodes.
15. The method of claim 11 wherein said at least one vent comprises two vents.
16. The method of claim 15 wherein said two vents are placed at staggered positions within along said sample cavity and further comprising directing said sample fluid along a fluid pathway.
17. The method of claim 16 wherein said test sensor is provided with a reagent disposed along said sample cavity, wherein said fluid pathway is tortuous, and further comprising mixing said test fluid with said reagent as said sample fluid is directed along said fluid pathway.
18. A sensor for analysis of a fluid sample comprising:
a sample cavity for accepting sample fluid, said sample cavity having an fluid inlet;
first and second vents within said sample cavity, said first and second vents having respective first and second vent edges and being disposed along a fluid pathway of said sample cavity such that said first vent is closer to said fluid inlet than said second vent is;
a first reagent area disposed along said sample cavity beneath said first vent;
and a second reagent area disposed along said sample cavity beneath said second vent.
19. The sensor of claim 18 wherein said first and second vents are spaced along said fluid pathway such that sample fluid entering said fluid inlet contacts said first and second vent edges in succession.
20. The sensor of claim 18 wherein said first reagent is adapted to react with said sample fluid for a first optimum reaction time and said second reagent is adapted to react with said sample fluid for a second optimum reaction time, said second optimum reaction time being less than said first optimum reaction time.
21. The sensor of claim 18 further comprising additional vents having vent edges and being disposed along said fluid pathway.
22. The sensor of claim 21 further comprising additional reagent areas disposed along said sample cavities respectively beneath said additional vents.
23. A method for analyzing a fluid sample comprising:
accepting said sample fluid within a sample cavity via capillary action, said sample cavity having a fluid inlet and first and second vents disposed along a fluid pathway, said sample cavity further having a first reagent disposed beneath said first vent and a second reagent disposed beneath said second vent, said first and second vents having first and second vent edges;
guiding said fluid sample along said fluid pathway via capillary action such that said fluid passes said first vent before passing said second vent; and filling said sample cavity such that said sample fluid first fills a first volume beneath said first vent and later fills a second volume beneath said second vent.
24. The method of claim 23 wherein a time delay between the time at which said sample fluid fills said first volume beneath said first vent and the time at which said sample fluid fills said second volume beneath said second vent is greater than about three seconds.
25. A sensor for analysis of a fluid sample comprising:
a base layer;
an electrode layer supported by said base layer, said electrode having a first electrode and a second electrode, said first and second electrodes respectfully extending from first and second electrode leads and having central portions;
a cover layer disposed above said electrode layer, said cover layer having a projection defining a sample cavity;
a fluid inlet area in fluid communication with said sample cavity; and first and second vents, said first vent having a first guide edge and said second vent having a second guide edge opposing said first guide edge, said first and second guide edges opposing each other above at least one of said central portions of said first and second electrodes.
26. The sensor of claim 25 wherein said electrodes have central portions, an intermediate area between said first and second opposing guide edges being disposed above one of said central portions of said electrodes.
27. A sensor for analysis of a fluid sample comprising:
a sample cavity having a fluid inlet area, said sample cavity adapted for being filled via capillary action and having a vent, said vent having at least one sample guide edge for guiding fluid under capillary action within said sample cavity during filling of said sample cavity.
CA2553633A 2004-02-06 2005-02-04 Fluid testing sensor having vents for directing fluid flow Expired - Fee Related CA2553633C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US54234804P 2004-02-06 2004-02-06
US60/542,348 2004-02-06
PCT/US2005/003624 WO2005078436A1 (en) 2004-02-06 2005-02-04 Fluid testing sensor having vents for directing fluid flow

Publications (2)

Publication Number Publication Date
CA2553633A1 true CA2553633A1 (en) 2005-08-25
CA2553633C CA2553633C (en) 2012-10-16

Family

ID=34860288

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2553633A Expired - Fee Related CA2553633C (en) 2004-02-06 2005-02-04 Fluid testing sensor having vents for directing fluid flow

Country Status (16)

Country Link
US (1) US7543481B2 (en)
EP (2) EP1714147B1 (en)
JP (1) JP4662952B2 (en)
KR (2) KR20120101692A (en)
CN (1) CN1918470B (en)
AU (1) AU2005213658A1 (en)
BR (1) BRPI0507378A (en)
CA (1) CA2553633C (en)
CR (1) CR8599A (en)
DK (1) DK1714147T3 (en)
ES (1) ES2507092T3 (en)
HK (1) HK1100496A1 (en)
MA (1) MA28352A1 (en)
NO (1) NO20063897L (en)
RU (1) RU2371722C2 (en)
WO (1) WO2005078436A1 (en)

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Also Published As

Publication number Publication date
WO2005078436A1 (en) 2005-08-25
KR101191093B1 (en) 2012-10-15
BRPI0507378A (en) 2007-07-10
JP4662952B2 (en) 2011-03-30
RU2371722C2 (en) 2009-10-27
EP1714147A1 (en) 2006-10-25
US7543481B2 (en) 2009-06-09
RU2006132053A (en) 2008-03-20
CN1918470A (en) 2007-02-21
EP1714147B1 (en) 2014-07-23
US20070062262A1 (en) 2007-03-22
KR20060131837A (en) 2006-12-20
CR8599A (en) 2007-09-07
AU2005213658A1 (en) 2005-08-25
CN1918470B (en) 2013-06-19
HK1100496A1 (en) 2007-09-21
DK1714147T3 (en) 2014-10-13
CA2553633C (en) 2012-10-16
MA28352A1 (en) 2006-12-01
ES2507092T3 (en) 2014-10-14
KR20120101692A (en) 2012-09-14
NO20063897L (en) 2006-09-01
EP2752662A1 (en) 2014-07-09
EP2752662B1 (en) 2020-01-29
JP2007521498A (en) 2007-08-02

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