CA2516190A1 - Wound treatment method and device - Google Patents
Wound treatment method and device Download PDFInfo
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- CA2516190A1 CA2516190A1 CA002516190A CA2516190A CA2516190A1 CA 2516190 A1 CA2516190 A1 CA 2516190A1 CA 002516190 A CA002516190 A CA 002516190A CA 2516190 A CA2516190 A CA 2516190A CA 2516190 A1 CA2516190 A1 CA 2516190A1
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- energy
- wound
- ultrasonic energy
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- ultrasonic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/203—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser applying laser energy to the outside of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0616—Skin treatment other than tanning
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00132—Setting operation time of a device
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00452—Skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/067—Radiation therapy using light using laser light
Abstract
The method and device of the present invention for wound treatment with a combination of laser and ultrasound waves comprises a probe to produce a laser beam and transducer to produce ultrasonic waves. The ultrasonic transducer has a tip with a distal end comprising a radiation surface. A liquid is directed to the radiation surface wherein an directed atomized particle spray of the liquid is created upon contact of the liquid with the radiation surface. The laser beam and spray directed to the wound from at least 0,1 inches transmits ultrasound waves as well as particles and has an radiation, irrigation, mechanical cleansing, liquid energizing and bactericide effect on the wound.
Description
WOUND TREATMENT METHOD AND DEVICE
Field of Invention The present invention relates to the treatment of wounds using ultrasound and laser energy.
In particular, the present invention relates to a method of spraying liquid drugs to the wound surface using ultrasonic waves for delivering drugs, killing bacteria, cleansing a surface, and stimulating healthy tissue cells and treating wound with laser energy.
BACKGROUND OF THE INVENTION
Ultrasonic waves and laser beams have been widely used in medical applications, including ~0 diagnostics and therapy, as well as many industrial applications.
Diagnostic use of ultrasound waves includes using ultrasonic waves to detect underlying structures in an object or human tissue. In this method, an ultrasonic transducer is placed in contact with the tissue (or object) via a coupling medium and high frequency (1-10 MHz) ultrasonic waves are directed into the tissue. Upon contact with the various underlying structures, the waves are reflected back to a receiver adjacent the 15 transducer. By comparing the signals of the ultrasonic wave as sent with the reflected ultrasonic wave as received, an image of the underlying structure can be produced. This technique is particularly useful for identifying boundaries between components of tissue and can be used to detect irregular masses, tumors, and the like.
Three therapeutic medical uses of ultrasound waves include aerosol mist production, contact 20 physiotherapy and soft tissue ablation. The ultrasound contact therapy procedure may cause a patient significant discomfort and/or pain and skin may appear raw and damaged.
Aerosol mist production makes use of a nebulizer or inhaler to produce an aerosol mist for creating a humid environment and delivering drug to the lungs.
Ultrasonic nebulizers operate by the passage of ultrasound waves of sufficient intensity through a liquid, the waves being directed at an air-liquid interface of the liquid from a point underneath or within the liquid. Liquid particles are ejected from the surface of the liquid into the surrounding air following the disintegration of capillary waves produced by the ultrasound. This technique can produce a very fine dense fog or mist. Aerosol mists produced by ultrasound are preferred because a smaller particle size of the aerosol can be obtained with the ultrasonic waves.
One of the major shortcomings of ultrasonic inhalers and nebulizers is that there is no directed aerosol to the target. An air stream is then required to direct the aerosol to the target, but this decreases the efficiency of ultrasound.
Ultrasonic sprayers, produced by Sonic and Materials Inc., Misonix Inc., Sono-Tek Inc., Zevex International, Tnc., and others, operate by passing liquid through a central orifice of an ultrasound instrument-tip. See, for example, U.S. Patent Nos. 3,765,606, 4,659,014, 5,104,042, 4,930,700, 4,153,201, 4,655,393, 5,516,043, 5,835,678, 5,879,364 and 5,843,139.
Ultrasonic inhalers and drug delivery systems from Medisonic USA, Inc. 3M, Siemens GmbH, The Procter & Gamble Company, Sheffield Pharmaceuticals, Aradigm, Inc., and others, operate by atomizing liquid using piezoceramic film. See, for example, U.S.
Patent Nos.
4,294,407, 5,347,998, 5,520,166, 5,960,792, 6,095,141, 6,102,298, 6,098,620, 6,026,808 and 6,106,547.
Medical usage of lasers can be divided in several groups: laser blood flow meters (Doppler), tissue ablation, therapy, revasculation and treatment devices, surgery devices, diagnostic device, and others. Medical laser devices from HGM Medical Lasers Inc., Level Laser Medical Systems, Coherent, Inc., ESC Medical Systems, PLC Medical Systems, Inc., Palomar Medical, Altus Medical, Tissue Medical Lasers, Inc. and others, appropriate for the therapy, dermatology, surgery, gynecology, urology, dentistry, veterinary and other applications, operate by atomizing liquid using piezoceramic film. See, for example, U.S. Patent Nos.
5,374,266, 5,527,350, 5,616,140, 5,707,403, 5,658,323, 6,027,495 and 5,989,245.
OBJECTS OF THE INVENTION
It is an object of the invention to provide an improved method and device for treating wounds.
It is also an object of the invention to provide an improved method and device for treating ~ 0 wounds using a combination of different energy sources, such as ultrasound and laser.
It is a further object of the invention to provide a method and device for delivering a drug, killing bacteria, cleansing a surface and stimulating healthy tissue cell growth.
It is yet a further object of the invention to treat a wound by spraying the surface of the wound with aerosol mist produced by ultrasonic waves and radiating by laser beam.
~ 5 These and other objects of the invention will become more apparent from the discussion below.
SUMMARY OF INVENTION
The present invention is a method and device using a combination of ultrasonic waves and laser beams to treat wounds. More particularly, the device of the invention creates, directs and 20 delivers ultrasound liquid aerosol spray and a laser beam to the wound surface for delivering drugs, killing bacteria, cleansing the surface, stimulating healthy tissue cells and treating the wound with ultrasound and laser energy. The method of the invention for treating wounds involves the use of a combination of a continuous or pulsed ultrasound waves and a beam of pulsed, scanned or gated continuous wave laser or incoherent radiation.
More particularly the method of the invention comprises producing a directed spray of liquid particles produced by contact of the liquid with a free end surface of an ultrasonic transducer, and the particle spray beam in combination with a laser beam are directed onto the wound. According to the method of the present invention a combination of ultrasonic waves, laser beams and energized medicines (highly activated by ultrasonic waves and laser beams) destroys the surface bacteria and results in a higher level of disinfection by the energized liquids as compared to ordinarily applied liquids. Additionally, the ultrasound and laser energy also stimulate healthy cell growth to aid in granulization and epithelization of healing tissue. Other applications of the method of the invention include non-medical uses, such as cleansing, sterilizing and coating surfaces of objects and food with various agents.
The method of the present invention offers an approach that may re-establish use of some traditional antibiotics and presents a method for fighting bacteria without antibiotics when IS necessary. The effect of the method of the present invention in highly activating antibiotics may allow some traditional antibiotics to overcome bacteria which have become resistant to that antibiotic. Moreover, independent of the energizing effect on antibiotics, the ultrasonic waves and laser beams which are applied in the method of the present invention also directly physically destroy bacteria. This combined effect has been shown to significantly increase the healing of purulent infected wounds.
This method of wound treatment is particularly advantageous on wounds for which local topical application of a drug is desirable but contact with the wound must be avoided.
Field of Invention The present invention relates to the treatment of wounds using ultrasound and laser energy.
In particular, the present invention relates to a method of spraying liquid drugs to the wound surface using ultrasonic waves for delivering drugs, killing bacteria, cleansing a surface, and stimulating healthy tissue cells and treating wound with laser energy.
BACKGROUND OF THE INVENTION
Ultrasonic waves and laser beams have been widely used in medical applications, including ~0 diagnostics and therapy, as well as many industrial applications.
Diagnostic use of ultrasound waves includes using ultrasonic waves to detect underlying structures in an object or human tissue. In this method, an ultrasonic transducer is placed in contact with the tissue (or object) via a coupling medium and high frequency (1-10 MHz) ultrasonic waves are directed into the tissue. Upon contact with the various underlying structures, the waves are reflected back to a receiver adjacent the 15 transducer. By comparing the signals of the ultrasonic wave as sent with the reflected ultrasonic wave as received, an image of the underlying structure can be produced. This technique is particularly useful for identifying boundaries between components of tissue and can be used to detect irregular masses, tumors, and the like.
Three therapeutic medical uses of ultrasound waves include aerosol mist production, contact 20 physiotherapy and soft tissue ablation. The ultrasound contact therapy procedure may cause a patient significant discomfort and/or pain and skin may appear raw and damaged.
Aerosol mist production makes use of a nebulizer or inhaler to produce an aerosol mist for creating a humid environment and delivering drug to the lungs.
Ultrasonic nebulizers operate by the passage of ultrasound waves of sufficient intensity through a liquid, the waves being directed at an air-liquid interface of the liquid from a point underneath or within the liquid. Liquid particles are ejected from the surface of the liquid into the surrounding air following the disintegration of capillary waves produced by the ultrasound. This technique can produce a very fine dense fog or mist. Aerosol mists produced by ultrasound are preferred because a smaller particle size of the aerosol can be obtained with the ultrasonic waves.
One of the major shortcomings of ultrasonic inhalers and nebulizers is that there is no directed aerosol to the target. An air stream is then required to direct the aerosol to the target, but this decreases the efficiency of ultrasound.
Ultrasonic sprayers, produced by Sonic and Materials Inc., Misonix Inc., Sono-Tek Inc., Zevex International, Tnc., and others, operate by passing liquid through a central orifice of an ultrasound instrument-tip. See, for example, U.S. Patent Nos. 3,765,606, 4,659,014, 5,104,042, 4,930,700, 4,153,201, 4,655,393, 5,516,043, 5,835,678, 5,879,364 and 5,843,139.
Ultrasonic inhalers and drug delivery systems from Medisonic USA, Inc. 3M, Siemens GmbH, The Procter & Gamble Company, Sheffield Pharmaceuticals, Aradigm, Inc., and others, operate by atomizing liquid using piezoceramic film. See, for example, U.S.
Patent Nos.
4,294,407, 5,347,998, 5,520,166, 5,960,792, 6,095,141, 6,102,298, 6,098,620, 6,026,808 and 6,106,547.
Medical usage of lasers can be divided in several groups: laser blood flow meters (Doppler), tissue ablation, therapy, revasculation and treatment devices, surgery devices, diagnostic device, and others. Medical laser devices from HGM Medical Lasers Inc., Level Laser Medical Systems, Coherent, Inc., ESC Medical Systems, PLC Medical Systems, Inc., Palomar Medical, Altus Medical, Tissue Medical Lasers, Inc. and others, appropriate for the therapy, dermatology, surgery, gynecology, urology, dentistry, veterinary and other applications, operate by atomizing liquid using piezoceramic film. See, for example, U.S. Patent Nos.
5,374,266, 5,527,350, 5,616,140, 5,707,403, 5,658,323, 6,027,495 and 5,989,245.
OBJECTS OF THE INVENTION
It is an object of the invention to provide an improved method and device for treating wounds.
It is also an object of the invention to provide an improved method and device for treating ~ 0 wounds using a combination of different energy sources, such as ultrasound and laser.
It is a further object of the invention to provide a method and device for delivering a drug, killing bacteria, cleansing a surface and stimulating healthy tissue cell growth.
It is yet a further object of the invention to treat a wound by spraying the surface of the wound with aerosol mist produced by ultrasonic waves and radiating by laser beam.
~ 5 These and other objects of the invention will become more apparent from the discussion below.
SUMMARY OF INVENTION
The present invention is a method and device using a combination of ultrasonic waves and laser beams to treat wounds. More particularly, the device of the invention creates, directs and 20 delivers ultrasound liquid aerosol spray and a laser beam to the wound surface for delivering drugs, killing bacteria, cleansing the surface, stimulating healthy tissue cells and treating the wound with ultrasound and laser energy. The method of the invention for treating wounds involves the use of a combination of a continuous or pulsed ultrasound waves and a beam of pulsed, scanned or gated continuous wave laser or incoherent radiation.
More particularly the method of the invention comprises producing a directed spray of liquid particles produced by contact of the liquid with a free end surface of an ultrasonic transducer, and the particle spray beam in combination with a laser beam are directed onto the wound. According to the method of the present invention a combination of ultrasonic waves, laser beams and energized medicines (highly activated by ultrasonic waves and laser beams) destroys the surface bacteria and results in a higher level of disinfection by the energized liquids as compared to ordinarily applied liquids. Additionally, the ultrasound and laser energy also stimulate healthy cell growth to aid in granulization and epithelization of healing tissue. Other applications of the method of the invention include non-medical uses, such as cleansing, sterilizing and coating surfaces of objects and food with various agents.
The method of the present invention offers an approach that may re-establish use of some traditional antibiotics and presents a method for fighting bacteria without antibiotics when IS necessary. The effect of the method of the present invention in highly activating antibiotics may allow some traditional antibiotics to overcome bacteria which have become resistant to that antibiotic. Moreover, independent of the energizing effect on antibiotics, the ultrasonic waves and laser beams which are applied in the method of the present invention also directly physically destroy bacteria. This combined effect has been shown to significantly increase the healing of purulent infected wounds.
This method of wound treatment is particularly advantageous on wounds for which local topical application of a drug is desirable but contact with the wound must be avoided.
The method of the present invention also provides a system of non-contact drug delivery with a combination of laser and ultrasound energy. The wound treatment method is effective when applied to the surface of the wound whether the liquid sprayed is a drug, such as an antibiotic, antiseptic, or equivalent agent, oil, saline, water or a combination of any of the foregoing.
The overall concept of the present invention relates to a method and apparatus for wound treatment using a combination of different energy sources, such as a laser, ultrasound, electric current, magnetic field, ultraviolet, microwaves, radio frequency, and or equivalent sources, as will be apparent to one skilled in this art.
While the invention has been described in general terms, the construction and obvious 1o advantages of the device and method of the present invention will be more clearly understood from the following description of the various specific embodiments when read in conjunction with the accompanying drawings.
BRIEF DESCRIPTION OF DRAWINGS
Fig. 1 is a schematic representation of a combined ultrasound and laser wound treatment system for use according to the present invention;
Fig. 2a is a schematic representation of a basic concept of the ultrasonic/laser device of the present invention, showing the ultrasonic spray and laser beams as mutually parallel;
Fig. 2b is a schematic representation of a basic concept of the ultrasonic/laser device of the present invention showing the ultrasonic spray and laser beams as non-parallel;
Fig. 2c is a schematic representation of a basic concept of the ultrasonic/laser device of the present invention showing the ultrasonic spray laser beams as coaxial;
Figs. 3a-3d are schematic representations of possible variations in the interaction of the laser beam and ultrasonic spray beam of the device depicted in Fig. l;
The overall concept of the present invention relates to a method and apparatus for wound treatment using a combination of different energy sources, such as a laser, ultrasound, electric current, magnetic field, ultraviolet, microwaves, radio frequency, and or equivalent sources, as will be apparent to one skilled in this art.
While the invention has been described in general terms, the construction and obvious 1o advantages of the device and method of the present invention will be more clearly understood from the following description of the various specific embodiments when read in conjunction with the accompanying drawings.
BRIEF DESCRIPTION OF DRAWINGS
Fig. 1 is a schematic representation of a combined ultrasound and laser wound treatment system for use according to the present invention;
Fig. 2a is a schematic representation of a basic concept of the ultrasonic/laser device of the present invention, showing the ultrasonic spray and laser beams as mutually parallel;
Fig. 2b is a schematic representation of a basic concept of the ultrasonic/laser device of the present invention showing the ultrasonic spray and laser beams as non-parallel;
Fig. 2c is a schematic representation of a basic concept of the ultrasonic/laser device of the present invention showing the ultrasonic spray laser beams as coaxial;
Figs. 3a-3d are schematic representations of possible variations in the interaction of the laser beam and ultrasonic spray beam of the device depicted in Fig. l;
Fig. 4a is a schematic representation of a method of delivery of energy in accordance with one embodiment of the present invention, showing first and second forms of energy;
Fig. 4b is a schematic representation of a method of delivery of energy in accordance with another embodiment of the present invention, showing ultrasonic energy delivered through a spray and a second form of energy delivered through pure air;
Fig. 4c is a schematic representation of a method of delivery of energy in accordance with a further embodiment of the present invention, showing ultrasonic energy delivered through pure air, and a second form of energy;
Fig. 5 is a schematic representation of an apparatus having first and second sources of energy directing energy to a wound in accordance with the present invention;
and Fig. 6 is a plot of experimental results achieved upon delivering ultrasound energy substantially through air only to a wound in accordance with the present invention.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
A device for wound treatment according to the present invention is illustrated in Fig. 1, which is a schematic representation of a side elevation of a preferred embodiment of the invention for wound treatment using ultrasound and laser energy. A body 12 has a front panel 13 having various regulatory controls, including controls for controlling on/off, display, intensity and others. Body 12 is connected to a hand piece 5 by an ultrasound cable 9 and a laser cable 10.
Hand piece 5 comprises a laser probe 15, an ultrasound transducer 14, and a liquid reservoir 2. Wound treatment solution 1 from a reservoir 2 is dispensed and delivered by valve 3 to contact the distal end of ultrasound transducer 14 and spray 6 onto the wound surface 8. At the same time, before or after laser source 15 is turned on and radiates the same wound surface 8. More detailed discussion of the operation of the ultrasound transducer can be found in commonly assigned, co-pending U.S. patent application Serial No. 09/684,044, filed October 6, 2000, and U.S. Patent No. 6,601,581 issued on August 5, 2003.
Figs. 2a-2c illustrate the basic concept of ultrasound - laser treatment of a wound according to the present invention. Fig. 2a is a schematic representation of the wound treatment method according to the present invention, where ultrasound spray and laser beam are directed to the wound in parallel. Fig. 2b is a schematic representation of the wound treatment method of the invention showing a coaxial-targeted ultrasound spray and laser beam. Fig. 2c is a schematic to representation of the wound treatment according to the invention showing a targeted ultrasound spray and laser beam at an angle to each other.
Figs. 3a-3d depict schematic representations of possible locations of laserprobe 15 and ultrasound transducer 14 relative to main body 5. The preferred location of the laser probe and the ultrasound transducer is shown in Fig. 3a, since it has been determined that this arrangement is ~ 5 most convenient, easy to handle and use. The alternative locations depicted in Figs. 3b-3d may provide more convenient arrangements in certain applications, as will be apparent to one skilled in this art.
Laser radiation and spray sonication can be activated simultaneously or separately. The preferred treatment method is a simultaneous radiation and sonication procedure, since 2o simultaneous treatment results in a doubling of laser and ultrasonic enhancement effect.
Main body 5 may or may not have disposable parts on the distal end to facilitate ease of use and sterilization.
While the preceding specific embodiments are illustrative of the practice of the invention, it will be understood by one skilled in this art that other expedients known to those skilled in the art or disclosed herein, may be employed without departing from the spirit of the invention or the scope of the appended claims.
The reservoir 2 may be filled with a powder instead of a liquid or in addition to a liquid, from which it is dispensed and delivered by valve 3 or through central orifice (not shown) to contact the distal end of the ultrasound transducer 14 from which it is atomized and delivered as a spray to the wound surface 8.
In another embodiment, ultrasonic energy is delivered to the wound without the use of the spray, i.e., the ultrasonic energy is delivered through a medium other than a spray, including a gaseous medium, such as pure air, e.g., ambient air, where the ultrasound transducer 14 is positioned at a non-contact distance from the wound. The ultrasound waves and the laser beams, even without the use of a spray, destroy surface bacteria and stimulate health cell growth. This method of wound treatment is particularly advantageous on wounds for which contact with the wound should be avoided. The laser energy may be delivered through the spray or through a medium other than the spray, including a gaseous medium, such as pure air.
In another embodiment, a combination of energy sources are provided at a non-contact distance from the wound, where the energy source or sources generate and direct toward the wound one or more of the following forms of energy: laser, ultrasound, electric current, magnetic, ultraviolet, microwave, radio frequency, infrared, coherent radiation, incoherent radiation, X-rays, gamma rays, etc.
Preferably, two forms of energy, i.e., first and second forms of energy, are generated from a position that is a non-contact distance from the wound and directed towards the wound _g_ for providing a therapeutic and beneficial effect. With reference to Figs. 4a-c, a combination of first and second forms of energy is shown. In Fig. 4a, the first and second forms of energy, 4p2 and 404, respectively, are different forms of energy each selected from the group consisting of:
laser, ultrasound, electric current, magnetic, ultraviolet, microwave, radio frequency, infrared, coherent radiation, incoherent radiation, X-rays, gamma rays, etc. In Fig. 4b, the first form of energy is ultrasonic energy. A spray directed toward the wound is formed by contacting a liquid or a powder with a radiation surface of an ultrasonic transducer. The ultrasonic energy is delivered to the wound through the spray. Ultrasonic energy may further be delivered to the wound through a medium other than the spray, including a gaseous medium, such as pure air.
1o The second form of energy is selected from the group consisting of: laser, electric current, magnetic, ultraviolet, microwave, radio frequency, infrared, coherent radiation, incoherent radiation, X-rays, gamma rays, etc. and may be delivered through the spray or through a medium other than the spray, including a gaseous medium, such as pure air, at an angle 8 with respect to the ultrasonic energy as shown by Fig. 4b, or some other angle.
15 In Fig. 4c, the first form of energy is ultrasound, and a liquid or powder is not contacted with the ultrasonic transducer for generating a spray and directing it to the wound. The second form of energy is selected from the group consisting of: laser, ultrasound, electric current, magnetic, ultraviolet, microwaves, radio frequency, infrared, coherent radiation, incoherent radiation, X-rays, gamma rays, etc., where the ultrasonic energy and the second form of energy 20 are delivered through a medium other than a spray, including a gaseous medium, such as pure ai r.
With reference to Fig. 5, an apparatus 500 is shown, where the apparatus 500 includes a first energy source 502 for generating and directing towards the wound 8 the first source of energy, and a second energy source 504 for generating and directing towards the wound 8 the second source of energy. The apparatus 500 and the first and second energy sources 502, 504 may each include one or more individual components, where the individual components are housed in separate housings and connected to each other by couplings, such as electric cables, A timer 506 is also included within the apparatus 500 for controlling the amount of time each energy source is activated. The timer 506 may successively activate the two energy sources 502, 504 (non-simultaneous activation) or may activate the two energy sources 502, 504 at the same time (simultaneous activation). The timer 506 may be controlled by a user via a control panel 508 or may contain built-in programmable instructions which are executed by a processor l0 510 of the apparatus 500.
In a preferred embodiment of the invention, wherein the ultrasonic energy is delivered to the wound through a gaseous medium, such as pure air, for achieving a therapeutic effect at the wound, the frequency of the ultrasonic energy generated is selected to be a low frequency so that using the low frequency selected an amplitude of the generated ultrasonic energy is achieved, 15 which is capable of being delivered to the wound with an intensity capable of providing a therapeutic effect to the wound. Preferably the amplitude achieved by the ultrasonic energy is at least 10 microns. Preferably the frequency used is in the range of 20kHz-50MHz, wherein a preferred limit is 20-200kHz, a more preferred limit is 20-40kHz and a most preferred value is 40kHz, wherein most preferably the lower limit of the frequency used is outside of the human 20 hearing range. Furthermore, it is advantageous to use a radiation surface having a shape and size selected to achieve delivery of the ultrasonic energy to wound wherein the delivered ultrasonic energy has an intensity capable of providing a therapeutic effect to the wound. Selection of the shape and size of the radiation surface in combination with selection of the frequency and amplitude of the ultrasonic energy used is advantageous in achieving delivery of the ultrasonic energy to the wound wherein the ultrasonic energy has an intensity capable of achieving a therapeutic effect to the wound. Preferably the perimeter radiation surface is round and has a relatively large diameter. Actual selection of the diameter is dependent upon the frequency and amplitude selected. Furthermore, the shape of the radiation surface is selected from one of flat, concave, convex, or a combination thereof.
With respect to Fig. 6, results are shown of experimentation performed in mid-January 2003 at Celleration Acoustic Laboratory, Eden Prairie, Minnesota. Ultrasonic energy having an intensity capable of providing a therapeutic effect was delivered substantially through air only to a wound using an ultrasound transducer positioned at a non-contact distance from the surface of the wound. The ultrasonic energy was generated at a frequency of 40kHz and an amplitude of 61 microns. The transducer radiation surface was flat, rounded and had a diameter of lcm.
Hydrophone Model number PVDF-Z44-1000 and Hydrophone Amplifier Model number Al7db, both manufactured by ONDA Corporation, Sunnyvale, California, were employed, using an amplifier gain of 7.44. Calibration of the hydrophone was performed by ONDA
Corporation. As shown, with the transducer positioned at a distance of between 2.5mm and 38mm, ultrasonic energy was delivered to the wound having an intensity capable of providing a therapeutic effect to the wound; the intensity being within the range of lOW/cm 2 and over 0.1 W/cm z .
Although the illustrative embodiments of the present invention have been described herein with reference to the accompanying drawings, it is to be understood that the invention is not limited to those precise embodiments, and that various other changes and modifications may be affected therein by one having ordinary skill in the art without departing from the scope or spirit of the invention. Accordingly, various modifications and variations can be made without departing from the spirit or scope of the invention as set forth in the following claims both literally and in equivalents recognized in law
Fig. 4b is a schematic representation of a method of delivery of energy in accordance with another embodiment of the present invention, showing ultrasonic energy delivered through a spray and a second form of energy delivered through pure air;
Fig. 4c is a schematic representation of a method of delivery of energy in accordance with a further embodiment of the present invention, showing ultrasonic energy delivered through pure air, and a second form of energy;
Fig. 5 is a schematic representation of an apparatus having first and second sources of energy directing energy to a wound in accordance with the present invention;
and Fig. 6 is a plot of experimental results achieved upon delivering ultrasound energy substantially through air only to a wound in accordance with the present invention.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
A device for wound treatment according to the present invention is illustrated in Fig. 1, which is a schematic representation of a side elevation of a preferred embodiment of the invention for wound treatment using ultrasound and laser energy. A body 12 has a front panel 13 having various regulatory controls, including controls for controlling on/off, display, intensity and others. Body 12 is connected to a hand piece 5 by an ultrasound cable 9 and a laser cable 10.
Hand piece 5 comprises a laser probe 15, an ultrasound transducer 14, and a liquid reservoir 2. Wound treatment solution 1 from a reservoir 2 is dispensed and delivered by valve 3 to contact the distal end of ultrasound transducer 14 and spray 6 onto the wound surface 8. At the same time, before or after laser source 15 is turned on and radiates the same wound surface 8. More detailed discussion of the operation of the ultrasound transducer can be found in commonly assigned, co-pending U.S. patent application Serial No. 09/684,044, filed October 6, 2000, and U.S. Patent No. 6,601,581 issued on August 5, 2003.
Figs. 2a-2c illustrate the basic concept of ultrasound - laser treatment of a wound according to the present invention. Fig. 2a is a schematic representation of the wound treatment method according to the present invention, where ultrasound spray and laser beam are directed to the wound in parallel. Fig. 2b is a schematic representation of the wound treatment method of the invention showing a coaxial-targeted ultrasound spray and laser beam. Fig. 2c is a schematic to representation of the wound treatment according to the invention showing a targeted ultrasound spray and laser beam at an angle to each other.
Figs. 3a-3d depict schematic representations of possible locations of laserprobe 15 and ultrasound transducer 14 relative to main body 5. The preferred location of the laser probe and the ultrasound transducer is shown in Fig. 3a, since it has been determined that this arrangement is ~ 5 most convenient, easy to handle and use. The alternative locations depicted in Figs. 3b-3d may provide more convenient arrangements in certain applications, as will be apparent to one skilled in this art.
Laser radiation and spray sonication can be activated simultaneously or separately. The preferred treatment method is a simultaneous radiation and sonication procedure, since 2o simultaneous treatment results in a doubling of laser and ultrasonic enhancement effect.
Main body 5 may or may not have disposable parts on the distal end to facilitate ease of use and sterilization.
While the preceding specific embodiments are illustrative of the practice of the invention, it will be understood by one skilled in this art that other expedients known to those skilled in the art or disclosed herein, may be employed without departing from the spirit of the invention or the scope of the appended claims.
The reservoir 2 may be filled with a powder instead of a liquid or in addition to a liquid, from which it is dispensed and delivered by valve 3 or through central orifice (not shown) to contact the distal end of the ultrasound transducer 14 from which it is atomized and delivered as a spray to the wound surface 8.
In another embodiment, ultrasonic energy is delivered to the wound without the use of the spray, i.e., the ultrasonic energy is delivered through a medium other than a spray, including a gaseous medium, such as pure air, e.g., ambient air, where the ultrasound transducer 14 is positioned at a non-contact distance from the wound. The ultrasound waves and the laser beams, even without the use of a spray, destroy surface bacteria and stimulate health cell growth. This method of wound treatment is particularly advantageous on wounds for which contact with the wound should be avoided. The laser energy may be delivered through the spray or through a medium other than the spray, including a gaseous medium, such as pure air.
In another embodiment, a combination of energy sources are provided at a non-contact distance from the wound, where the energy source or sources generate and direct toward the wound one or more of the following forms of energy: laser, ultrasound, electric current, magnetic, ultraviolet, microwave, radio frequency, infrared, coherent radiation, incoherent radiation, X-rays, gamma rays, etc.
Preferably, two forms of energy, i.e., first and second forms of energy, are generated from a position that is a non-contact distance from the wound and directed towards the wound _g_ for providing a therapeutic and beneficial effect. With reference to Figs. 4a-c, a combination of first and second forms of energy is shown. In Fig. 4a, the first and second forms of energy, 4p2 and 404, respectively, are different forms of energy each selected from the group consisting of:
laser, ultrasound, electric current, magnetic, ultraviolet, microwave, radio frequency, infrared, coherent radiation, incoherent radiation, X-rays, gamma rays, etc. In Fig. 4b, the first form of energy is ultrasonic energy. A spray directed toward the wound is formed by contacting a liquid or a powder with a radiation surface of an ultrasonic transducer. The ultrasonic energy is delivered to the wound through the spray. Ultrasonic energy may further be delivered to the wound through a medium other than the spray, including a gaseous medium, such as pure air.
1o The second form of energy is selected from the group consisting of: laser, electric current, magnetic, ultraviolet, microwave, radio frequency, infrared, coherent radiation, incoherent radiation, X-rays, gamma rays, etc. and may be delivered through the spray or through a medium other than the spray, including a gaseous medium, such as pure air, at an angle 8 with respect to the ultrasonic energy as shown by Fig. 4b, or some other angle.
15 In Fig. 4c, the first form of energy is ultrasound, and a liquid or powder is not contacted with the ultrasonic transducer for generating a spray and directing it to the wound. The second form of energy is selected from the group consisting of: laser, ultrasound, electric current, magnetic, ultraviolet, microwaves, radio frequency, infrared, coherent radiation, incoherent radiation, X-rays, gamma rays, etc., where the ultrasonic energy and the second form of energy 20 are delivered through a medium other than a spray, including a gaseous medium, such as pure ai r.
With reference to Fig. 5, an apparatus 500 is shown, where the apparatus 500 includes a first energy source 502 for generating and directing towards the wound 8 the first source of energy, and a second energy source 504 for generating and directing towards the wound 8 the second source of energy. The apparatus 500 and the first and second energy sources 502, 504 may each include one or more individual components, where the individual components are housed in separate housings and connected to each other by couplings, such as electric cables, A timer 506 is also included within the apparatus 500 for controlling the amount of time each energy source is activated. The timer 506 may successively activate the two energy sources 502, 504 (non-simultaneous activation) or may activate the two energy sources 502, 504 at the same time (simultaneous activation). The timer 506 may be controlled by a user via a control panel 508 or may contain built-in programmable instructions which are executed by a processor l0 510 of the apparatus 500.
In a preferred embodiment of the invention, wherein the ultrasonic energy is delivered to the wound through a gaseous medium, such as pure air, for achieving a therapeutic effect at the wound, the frequency of the ultrasonic energy generated is selected to be a low frequency so that using the low frequency selected an amplitude of the generated ultrasonic energy is achieved, 15 which is capable of being delivered to the wound with an intensity capable of providing a therapeutic effect to the wound. Preferably the amplitude achieved by the ultrasonic energy is at least 10 microns. Preferably the frequency used is in the range of 20kHz-50MHz, wherein a preferred limit is 20-200kHz, a more preferred limit is 20-40kHz and a most preferred value is 40kHz, wherein most preferably the lower limit of the frequency used is outside of the human 20 hearing range. Furthermore, it is advantageous to use a radiation surface having a shape and size selected to achieve delivery of the ultrasonic energy to wound wherein the delivered ultrasonic energy has an intensity capable of providing a therapeutic effect to the wound. Selection of the shape and size of the radiation surface in combination with selection of the frequency and amplitude of the ultrasonic energy used is advantageous in achieving delivery of the ultrasonic energy to the wound wherein the ultrasonic energy has an intensity capable of achieving a therapeutic effect to the wound. Preferably the perimeter radiation surface is round and has a relatively large diameter. Actual selection of the diameter is dependent upon the frequency and amplitude selected. Furthermore, the shape of the radiation surface is selected from one of flat, concave, convex, or a combination thereof.
With respect to Fig. 6, results are shown of experimentation performed in mid-January 2003 at Celleration Acoustic Laboratory, Eden Prairie, Minnesota. Ultrasonic energy having an intensity capable of providing a therapeutic effect was delivered substantially through air only to a wound using an ultrasound transducer positioned at a non-contact distance from the surface of the wound. The ultrasonic energy was generated at a frequency of 40kHz and an amplitude of 61 microns. The transducer radiation surface was flat, rounded and had a diameter of lcm.
Hydrophone Model number PVDF-Z44-1000 and Hydrophone Amplifier Model number Al7db, both manufactured by ONDA Corporation, Sunnyvale, California, were employed, using an amplifier gain of 7.44. Calibration of the hydrophone was performed by ONDA
Corporation. As shown, with the transducer positioned at a distance of between 2.5mm and 38mm, ultrasonic energy was delivered to the wound having an intensity capable of providing a therapeutic effect to the wound; the intensity being within the range of lOW/cm 2 and over 0.1 W/cm z .
Although the illustrative embodiments of the present invention have been described herein with reference to the accompanying drawings, it is to be understood that the invention is not limited to those precise embodiments, and that various other changes and modifications may be affected therein by one having ordinary skill in the art without departing from the scope or spirit of the invention. Accordingly, various modifications and variations can be made without departing from the spirit or scope of the invention as set forth in the following claims both literally and in equivalents recognized in law
Claims (43)
1. An apparatus for treating a wound using ultrasonic energy and another form of energy comprising:
means for generating ultrasonic energy; and means for generating another form of energy, wherein the means for generating the ultrasonic energy and another form of energy include components of a device for generating both the ultrasonic energy and the another form of energy, wherein the means for generating the ultrasonic energy and the another form of energy are positioned at a non-contact distance from the wound, and wherein delivery of the ultrasonic energy and another form of energy to the wound provides a therapeutic effect for decreasing the healing time of the wound, wherein the another form of energy is selected from the group consisting of laser, electric current, magnetic, ultraviolet, microwave, radio frequency, infrared light, coherent radiation, incoherent radiation, X-rays, and gamma. rays.
means for generating ultrasonic energy; and means for generating another form of energy, wherein the means for generating the ultrasonic energy and another form of energy include components of a device for generating both the ultrasonic energy and the another form of energy, wherein the means for generating the ultrasonic energy and the another form of energy are positioned at a non-contact distance from the wound, and wherein delivery of the ultrasonic energy and another form of energy to the wound provides a therapeutic effect for decreasing the healing time of the wound, wherein the another form of energy is selected from the group consisting of laser, electric current, magnetic, ultraviolet, microwave, radio frequency, infrared light, coherent radiation, incoherent radiation, X-rays, and gamma. rays.
2. The apparatus according to Claim 1, further comprising:
means for introducing a material to the means for generating ultrasonic energy to generate a spray, wherein at least a portion of the ultrasonic energy is delivered to the wound through the spray.
means for introducing a material to the means for generating ultrasonic energy to generate a spray, wherein at least a portion of the ultrasonic energy is delivered to the wound through the spray.
3. The apparatus according to Claim 1, wherein at least one of the ultrasonic energy and another form of energy is delivered to the wound through a gaseous medium.
4, The apparatus according to Claim 1, wherein at least one of the ultrasonic energy and another form of energy is delivered to the wound through a spray.
5. The apparatus according to Claim 2, wherein the material is one of a fluid and a powder.
6. Canceled
7. The apparatus according to Claim 1, further comprising means for automatically controlling the activation time of the means for generating ultrasonic energy and the means for generating the another form of energy for providing one of simultaneous and non-simultaneous activation thereof.
8. A method for treating a wound using ultrasonic energy combined with.
another form of energy, said method comprising the steps of:
providing an ultrasound transducer at a distance from the surface of the wound for emitting ultrasonic energy;
generating a spray by contacting a material with a portion of the ultrasound transducer;
providing a source for generating the other form of energy at a distance from the surface of the wound for emitting the other form of energy;
delivering the other form of energy to the wound; and delivering the ultrasonic energy to the wound through the spray, wherein delivery of the ultrasonic and other form of energy to the wound provides a therapeutic effect for decreasing the healing time of the wound.
another form of energy, said method comprising the steps of:
providing an ultrasound transducer at a distance from the surface of the wound for emitting ultrasonic energy;
generating a spray by contacting a material with a portion of the ultrasound transducer;
providing a source for generating the other form of energy at a distance from the surface of the wound for emitting the other form of energy;
delivering the other form of energy to the wound; and delivering the ultrasonic energy to the wound through the spray, wherein delivery of the ultrasonic and other form of energy to the wound provides a therapeutic effect for decreasing the healing time of the wound.
9. The method according to Claim 8, wherein the step of delivering the other form of energy comprises the step of delivering the other form of energy to the wound through one of the spray and pure air.
10. The method according to Claim 8, wherein the material is one of a fluid and a powder.
11. The method according to Claim 8, wherein the other form of energy is selected from the group consisting of: laser, electric current, magnetic, ultraviolet, microwave, radio frequency, infrared light, coherent radiation, incoherent radiation, X-rays, and gamma rays.
12. The method according to Claim 8, further comprising the step of controlling emissive of the ultrasonic energy and the other form of energy for providing one of simultaneous and non-simultaneous emission thereof.
13. An apparatus for treating a wound using ultrasound and laser energy comprising:
means for generating ultrasonic energy positioned at a non-contact distance from the surface of the wound;
means for introducing a material to the means for generating ultrasonic energy to generate a spray;
means for generating laser energy in the direction of the spray and at a non-contact distance from the surface of the wound, wherein delivery of the ultrasonic energy and the laser energy to the wound provides a therapeutic effect for decreasing the healing time of the wound; and means for automatically controlling the activation time of the means for generating ultrasonic energy and the means for generating laser energy.
means for generating ultrasonic energy positioned at a non-contact distance from the surface of the wound;
means for introducing a material to the means for generating ultrasonic energy to generate a spray;
means for generating laser energy in the direction of the spray and at a non-contact distance from the surface of the wound, wherein delivery of the ultrasonic energy and the laser energy to the wound provides a therapeutic effect for decreasing the healing time of the wound; and means for automatically controlling the activation time of the means for generating ultrasonic energy and the means for generating laser energy.
14. The apparatus according to Claim 13, wherein the laser energy is delivered to the wound through one of the spray and a gaseous medium.
15. The apparatus according to Claim 13, wherein the material is one of a fluid and a powder.
16. The apparatus according to Claim 13, wherein the means for automatically controlling the activation time of the means for generating ultrasonic energy and the means for generating laser energy provides for one of simultaneous and non-simultaneous activation of the means for generating ultrasonic energy and the means for generating laser energy.
17. An apparatus for treating a wound using ultrasound and laser energy comprising:
means for generating ultrasonic energy positioned at a non-contact distance from the surface of the wound for delivering ultrasonic energy from the non-contact distance to the surface of the wound through a gaseous medium; and means for generating laser energy positioned at a non-contact distance from the surface of the wound, wherein the means for generating ultrasonic energy and the means for generating laser energy include components of a device for generating both the ultrasonic energy and the laser energy, and wherein combined delivery of the ultrasonic energy and the laser energy to the wound provides a therapeutic effect for decreasing the healing time of the wound.
means for generating ultrasonic energy positioned at a non-contact distance from the surface of the wound for delivering ultrasonic energy from the non-contact distance to the surface of the wound through a gaseous medium; and means for generating laser energy positioned at a non-contact distance from the surface of the wound, wherein the means for generating ultrasonic energy and the means for generating laser energy include components of a device for generating both the ultrasonic energy and the laser energy, and wherein combined delivery of the ultrasonic energy and the laser energy to the wound provides a therapeutic effect for decreasing the healing time of the wound.
18. Canceled
19. The apparatus according to Claim 17, wherein the means for generating ultrasonic energy generates ultrasonic waves having a significantly high amplitude for being delivered to the wound such that upon delivery the ultrasonic energy has an intensity capable of achieving the therapeutic effect.
20. The apparatus according to Claim 19, wherein the generated ultrasonic energy has a significantly low frequency for achieving the significantly high amplitude.
21. The apparatus according to Claim 19, wherein the significantly high amplitude is greater than 10 microns.
22. The apparatus according to Claim 20, wherein the significantly low frequency is within the range of 20kHz-50MHz for achieving the significantly high amplitude.
23. The apparatus according to Claim 20, wherein the significantly low frequency is within the range of 20-200kHz for achieving the significantly high amplitude.
24. The apparatus according to Claim 20, wherein the significantly low frequency is within the range of 20-40kHz for achieving the significantly high amplitude.
25. The apparatus according to Claim 17, wherein a surface area of a radiation surface of the means for generating ultrasonic energy is significantly large for achieving delivery of ultrasonic energy to the wound having an intensity capable of achieving the therapeutic effect.
26. The apparatus according to Claim 17, wherein a perimeter of a radiation surface of the means for generating ultrasonic energy is rounded for achieving delivery of ultrasonic energy to the wound having an intensity capable of achieving the therapeutic effect.
27. The apparatus according to Claim 17, wherein a selection is made of at least one of a size of a surface area of a radiation surface of the means for generating ultrasonic energy, a shape of a peripherial boundary of the radiation surface, a frequency of the ultrasonic energy generated, and an amplitude of the ultrasonic energy generated for achieving delivery of ultrasonic energy to the wound having an intensity capable of achieving the therapeutic effect.
28 28. The apparatus according to Claim 17, wherein a selection is made of a combination of the size of a surface area of a radiation surface of the means for generating ultrasonic energy; a shape of a peripheral boundary of the curvature of the radiation surface; a shape of the radiation surface selected from one of flat, concave, convex and a combination thereof; a frequency of the ultrasonic energy generated; and an amplitude of the ultrasonic energy generated for achieving delivery of ultrasonic energy to the wound having an intensity capable of achieving the therapeutic effect.
29. A method for treating a wound using ultrasound and laser energy comprising:
generating ultrasonic energy from a non-contact distance from the surface of the wound;
generating laser energy from a non-contact distance from the surface of the wound;
and delivering the ultrasonic energy and the laser energy to the wound in combination for providing a therapeutic effect for decreasing the healing time of the wound, wherein the ultrasonic energy and the laser energy are generated by the same device.
generating ultrasonic energy from a non-contact distance from the surface of the wound;
generating laser energy from a non-contact distance from the surface of the wound;
and delivering the ultrasonic energy and the laser energy to the wound in combination for providing a therapeutic effect for decreasing the healing time of the wound, wherein the ultrasonic energy and the laser energy are generated by the same device.
30. The method according to Claim 29, wherein the delivering step includes delivering the ultrasonic energy to the wound through a gaseous medium.
31. The method according to Claim 29, wherein the generating ultrasonic energy step includes generating ultrasonic waves with a significantly high amplitude for being delivered to the wound such that upon delivery the ultrasonic energy has an intensity capable of achieving the therapeutic effect.
32. The method according to Claim 31, wherein the generating ultrasonic energy step includes generating the ultrasonic energy with a significantly low frequency for achieving the significantly high amplitude.
33. The method according to Claim 29, wherein the generating ultrasonic energy step includes generating the ultrasonic energy from a radiation surface having a significantly large surface area for achieving delivery of ultrasonic energy to the wound having an intensity capable of achieving the therapeutic effect.
34. The method according to Claim 29, wherein the generating ultrasonic energy step includes generating the ultrasonic energy from a radiation surface having a rounded peripheral boundary for achieving delivery of ultrasonic energy to the wound having an intensity capable of achieving the therapeutic effect.
35. The method according to Claim 29, wherein the generating ultrasonic energy step includes selecting a combination of a size of a surface area of a radiation surface; a shape of a peripheral boundary of the radiation surface; a shape of the curvature of the radiation surface selected from one of flat, concave, convex and a combination thereof;
a frequency of the ultrasonic energy; and an amplitude of the ultrasonic energy for achieving delivery of ultrasonic energy to the wound having an intensity capable of achieving the therapeutic effect.
a frequency of the ultrasonic energy; and an amplitude of the ultrasonic energy for achieving delivery of ultrasonic energy to the wound having an intensity capable of achieving the therapeutic effect.
36. An apparatus for treating a wound using first and second forms of energy comprising:
means for generating a first form of energy; and means for generating a second form of energy, wherein the means for generating the first and second forms of energy are positioned at a non-contact distance from the wound, wherein at least one of the first and second forms of energy is delivered to the wound through a spray, and wherein delivery of the first and second forms of energy to the wound provides a therapeutic effect for decreasing the healing time of the wound, wherein the first and second forms of energy are selected from the group consisting of: laser, electric current, magnetic, ultraviolet, microwave, radio frequency, infrared light, coherent radiation, incoherent radiation, X-rays, and gamma rays.
means for generating a first form of energy; and means for generating a second form of energy, wherein the means for generating the first and second forms of energy are positioned at a non-contact distance from the wound, wherein at least one of the first and second forms of energy is delivered to the wound through a spray, and wherein delivery of the first and second forms of energy to the wound provides a therapeutic effect for decreasing the healing time of the wound, wherein the first and second forms of energy are selected from the group consisting of: laser, electric current, magnetic, ultraviolet, microwave, radio frequency, infrared light, coherent radiation, incoherent radiation, X-rays, and gamma rays.
37. The apparatus according to Claim 36, wherein the means for generating the first form of energy includes means for generating ultrasonic energy; and further comprising:
means for introducing a material to the means for generating ultrasonic energy to generate a spray, wherein at least a portion of the ultrasonic energy is delivered to the wound through the spray.
means for introducing a material to the means for generating ultrasonic energy to generate a spray, wherein at least a portion of the ultrasonic energy is delivered to the wound through the spray.
38. Canceled.
39. The apparatus according to Claim 36, further comprising means for controlling activation of the means for generating the first form of energy and the means for generating the second form of energy for providing one of simultaneous and non-simultaneous activation thereof.
40. An apparatus for treating a wound using ultrasound and laser energy comprising:
means for generating ultrasonic energy positioned at a non-contact distance from the surface of the wound, wherein the ultrasonic energy is delivered from the non-contact distance to the wound through a gaseous medium; and means for generating laser energy at a non-contact distance from the surface of the wound, wherein the means for generating ultrasonic energy and the means for generating laser energy include components housed within the same housing, and wherein delivery of the ultrasonic energy and the laser energy to the wound provides a therapeutic effect for decreasing the healing time of the wound.
means for generating ultrasonic energy positioned at a non-contact distance from the surface of the wound, wherein the ultrasonic energy is delivered from the non-contact distance to the wound through a gaseous medium; and means for generating laser energy at a non-contact distance from the surface of the wound, wherein the means for generating ultrasonic energy and the means for generating laser energy include components housed within the same housing, and wherein delivery of the ultrasonic energy and the laser energy to the wound provides a therapeutic effect for decreasing the healing time of the wound.
41. The apparatus according to Claim 40, further comprising means for automatically controlling the activation time of the means for generating ultrasonic energy and the means for generating laser energy for providing one of simultaneous and non-simultaneous activation thereof.
42. The apparatus according to Claim 17, further comprising means for automatically controlling the activation time of the means for generating ultrasonic energy and the means for generating laser energy for providing one of simultaneous and non-simultaneous activation thereof.
43-45. Canceled.
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PCT/US2004/002962 WO2004089469A1 (en) | 2003-02-14 | 2004-02-03 | Wound treatment method and device |
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Families Citing this family (91)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080027328A1 (en) * | 1997-12-29 | 2008-01-31 | Julia Therapeutics, Llc | Multi-focal treatment of skin with acoustic energy |
US20060184071A1 (en) * | 1997-12-29 | 2006-08-17 | Julia Therapeutics, Llc | Treatment of skin with acoustic energy |
US6964647B1 (en) * | 2000-10-06 | 2005-11-15 | Ellaz Babaev | Nozzle for ultrasound wound treatment |
US8235919B2 (en) | 2001-01-12 | 2012-08-07 | Celleration, Inc. | Ultrasonic method and device for wound treatment |
US7914470B2 (en) | 2001-01-12 | 2011-03-29 | Celleration, Inc. | Ultrasonic method and device for wound treatment |
US6960173B2 (en) * | 2001-01-30 | 2005-11-01 | Eilaz Babaev | Ultrasound wound treatment method and device using standing waves |
EP1466565A4 (en) * | 2002-01-18 | 2010-04-21 | Teijin Ltd | Method of treating osteochondritis and apparatus for treating osteochondritis |
US7435252B2 (en) * | 2003-10-15 | 2008-10-14 | Valam Corporation | Control of microorganisms in the sino-nasal tract |
US20060212029A1 (en) * | 2004-02-20 | 2006-09-21 | Arcusa Villacampa Francisco J | Equipment and method for reducing and eliminating wrinkles in the skin |
US20060015157A1 (en) * | 2004-07-14 | 2006-01-19 | Leong Vong V | Method and apparatus for particle radiation therapy and practice of particle medicine |
US20060047281A1 (en) | 2004-09-01 | 2006-03-02 | Syneron Medical Ltd. | Method and system for invasive skin treatment |
US8535228B2 (en) | 2004-10-06 | 2013-09-17 | Guided Therapy Systems, Llc | Method and system for noninvasive face lifts and deep tissue tightening |
US10864385B2 (en) | 2004-09-24 | 2020-12-15 | Guided Therapy Systems, Llc | Rejuvenating skin by heating tissue for cosmetic treatment of the face and body |
US8444562B2 (en) | 2004-10-06 | 2013-05-21 | Guided Therapy Systems, Llc | System and method for treating muscle, tendon, ligament and cartilage tissue |
US20120016239A1 (en) * | 2004-10-06 | 2012-01-19 | Guided Therapy Systems, Llc | Systems for cosmetic treatment |
US8133180B2 (en) | 2004-10-06 | 2012-03-13 | Guided Therapy Systems, L.L.C. | Method and system for treating cellulite |
US20060111744A1 (en) | 2004-10-13 | 2006-05-25 | Guided Therapy Systems, L.L.C. | Method and system for treatment of sweat glands |
US11883688B2 (en) | 2004-10-06 | 2024-01-30 | Guided Therapy Systems, Llc | Energy based fat reduction |
US9694212B2 (en) | 2004-10-06 | 2017-07-04 | Guided Therapy Systems, Llc | Method and system for ultrasound treatment of skin |
WO2006042163A2 (en) | 2004-10-06 | 2006-04-20 | Guided Therapy Systems, L.L.C. | Method and system for cosmetic enhancement |
ES2643864T3 (en) | 2004-10-06 | 2017-11-24 | Guided Therapy Systems, L.L.C. | Procedure and system for the treatment of tissues by ultrasound |
US9827449B2 (en) | 2004-10-06 | 2017-11-28 | Guided Therapy Systems, L.L.C. | Systems for treating skin laxity |
US8690779B2 (en) | 2004-10-06 | 2014-04-08 | Guided Therapy Systems, Llc | Noninvasive aesthetic treatment for tightening tissue |
US11235179B2 (en) | 2004-10-06 | 2022-02-01 | Guided Therapy Systems, Llc | Energy based skin gland treatment |
US11724133B2 (en) | 2004-10-07 | 2023-08-15 | Guided Therapy Systems, Llc | Ultrasound probe for treatment of skin |
US11207548B2 (en) | 2004-10-07 | 2021-12-28 | Guided Therapy Systems, L.L.C. | Ultrasound probe for treating skin laxity |
WO2006060792A2 (en) * | 2004-11-30 | 2006-06-08 | The Administrators Of The Tulane Educational Fund | Nebulizing treatment method |
CN100542635C (en) * | 2005-01-10 | 2009-09-23 | 重庆海扶(Hifu)技术有限公司 | High intensity focused ultrasound therapy device and method |
US8109981B2 (en) * | 2005-01-25 | 2012-02-07 | Valam Corporation | Optical therapies and devices |
US7785277B2 (en) | 2005-06-23 | 2010-08-31 | Celleration, Inc. | Removable applicator nozzle for ultrasound wound therapy device |
US7713218B2 (en) * | 2005-06-23 | 2010-05-11 | Celleration, Inc. | Removable applicator nozzle for ultrasound wound therapy device |
US9101949B2 (en) | 2005-08-04 | 2015-08-11 | Eilaz Babaev | Ultrasonic atomization and/or seperation system |
US20070031611A1 (en) * | 2005-08-04 | 2007-02-08 | Babaev Eilaz P | Ultrasound medical stent coating method and device |
US20070167824A1 (en) * | 2005-11-30 | 2007-07-19 | Warren Lee | Method of manufacture of catheter tips, including mechanically scanning ultrasound probe catheter tip, and apparatus made by the method |
US20070167826A1 (en) * | 2005-11-30 | 2007-07-19 | Warren Lee | Apparatuses for thermal management of actuated probes, such as catheter distal ends |
US20070167825A1 (en) * | 2005-11-30 | 2007-07-19 | Warren Lee | Apparatus for catheter tips, including mechanically scanning ultrasound probe catheter tip |
US20080146970A1 (en) * | 2005-12-06 | 2008-06-19 | Julia Therapeutics, Llc | Gel dispensers for treatment of skin with acoustic energy |
US7943352B2 (en) | 2006-03-29 | 2011-05-17 | Bacoustics, Llc | Apparatus and methods for vaccine development using ultrasound technology |
US8709056B2 (en) * | 2006-04-10 | 2014-04-29 | Bwt Property Inc | Phototherapy apparatus with built-in ultrasonic image module |
US7662177B2 (en) | 2006-04-12 | 2010-02-16 | Bacoustics, Llc | Apparatus and methods for pain relief using ultrasound waves in combination with cryogenic energy |
US7431704B2 (en) * | 2006-06-07 | 2008-10-07 | Bacoustics, Llc | Apparatus and method for the treatment of tissue with ultrasound energy by direct contact |
US8562547B2 (en) | 2006-06-07 | 2013-10-22 | Eliaz Babaev | Method for debriding wounds |
AU2007286660A1 (en) * | 2006-08-25 | 2008-02-28 | Eilaz Babaev | Portable ultrasound device for the treatment of wounds |
US20080097252A1 (en) * | 2006-08-25 | 2008-04-24 | Eilaz Babaev | Ultrasound and Pressure Therapy Wound Care Device |
US8050752B2 (en) * | 2006-09-29 | 2011-11-01 | Bacoustics, Llc | Method of treating lumens, cavities, and tissues of the body with an ultrasound delivered liquid |
US7846341B2 (en) * | 2006-12-04 | 2010-12-07 | Bacoustics, Llc | Method of ultrasonically treating a continuous flow of fluid |
US8491521B2 (en) | 2007-01-04 | 2013-07-23 | Celleration, Inc. | Removable multi-channel applicator nozzle |
US20080243047A1 (en) * | 2007-03-27 | 2008-10-02 | Babaev Eilaz P | Ultrasound wound care device |
DE202007007920U1 (en) * | 2007-05-31 | 2008-10-09 | Storz Medical Ag | Medical device for the treatment of the human or animal body |
US7896854B2 (en) | 2007-07-13 | 2011-03-01 | Bacoustics, Llc | Method of treating wounds by creating a therapeutic solution with ultrasonic waves |
US7901388B2 (en) | 2007-07-13 | 2011-03-08 | Bacoustics, Llc | Method of treating wounds by creating a therapeutic solution with ultrasonic waves |
WO2009090632A2 (en) | 2008-01-17 | 2009-07-23 | Syneron Medical Ltd. | A hair removal apparatus for personal use and the method of using same |
US20120022512A1 (en) * | 2008-01-24 | 2012-01-26 | Boris Vaynberg | Device, apparatus, and method of adipose tissue treatment |
CN101951851B (en) | 2008-01-24 | 2013-02-06 | 赛诺龙医疗公司 | A device and apparatus of adipose tissue treatment |
US8016208B2 (en) | 2008-02-08 | 2011-09-13 | Bacoustics, Llc | Echoing ultrasound atomization and mixing system |
US7950594B2 (en) * | 2008-02-11 | 2011-05-31 | Bacoustics, Llc | Mechanical and ultrasound atomization and mixing system |
US7830070B2 (en) * | 2008-02-12 | 2010-11-09 | Bacoustics, Llc | Ultrasound atomization system |
US8206326B2 (en) * | 2008-03-04 | 2012-06-26 | Sound Surgical Technologies, Llc | Combination ultrasound-phototherapy transducer |
CN101569781A (en) * | 2008-04-30 | 2009-11-04 | 姚广权 | Device for curing wound cut |
CN104545998B (en) | 2008-06-06 | 2020-07-14 | 奥赛拉公司 | System and method for cosmetic treatment and imaging |
US9314293B2 (en) | 2008-07-16 | 2016-04-19 | Syneron Medical Ltd | RF electrode for aesthetic and body shaping devices and method of using same |
US20100017750A1 (en) | 2008-07-16 | 2010-01-21 | Avner Rosenberg | User interface |
US20120022504A1 (en) * | 2008-09-11 | 2012-01-26 | Syneron Medical Ltd. | Device, apparatus, and method of adipose tissue treatment |
EP2334249B1 (en) | 2008-09-21 | 2013-03-13 | Syneron Medical Ltd. | A method and apparatus for personal skin treatment |
JP2012513837A (en) | 2008-12-24 | 2012-06-21 | ガイデッド セラピー システムズ, エルエルシー | Method and system for fat loss and / or cellulite treatment |
US8606366B2 (en) | 2009-02-18 | 2013-12-10 | Syneron Medical Ltd. | Skin treatment apparatus for personal use and method for using same |
EP2730313A1 (en) | 2009-02-25 | 2014-05-14 | Syneron Medical Ltd. | Electrical skin rejuvenation |
FR2949067B1 (en) * | 2009-08-13 | 2012-08-17 | Stephane Collet | TECHNOLOGICAL DEVICE COMBINING HIGHLY FOCUSED THERAPEUTIC ULTRASOUND (HFU) LINEAR AND COLD LASER HIGH INTENSITY SCAN |
JP5701895B2 (en) | 2009-12-06 | 2015-04-15 | シネロン メディカル リミテッド | Method and apparatus for personal skin treatment |
US8944050B2 (en) * | 2010-08-13 | 2015-02-03 | The Corporation Of Mercer University | Inhalation airflow regulation devices and methods of using the same |
CN102258423B (en) * | 2011-04-29 | 2013-01-23 | 重庆川仪自动化股份有限公司 | Ultrasonic debridement machine |
US9072521B2 (en) * | 2012-06-08 | 2015-07-07 | Home Skinovations Ltd. | Non-invasive device for treating body tissue |
US9510802B2 (en) | 2012-09-21 | 2016-12-06 | Guided Therapy Systems, Llc | Reflective ultrasound technology for dermatological treatments |
CN204017181U (en) | 2013-03-08 | 2014-12-17 | 奥赛拉公司 | Aesthstic imaging and processing system, multifocal processing system and perform the system of aesthetic procedure |
US10413359B2 (en) * | 2013-07-18 | 2019-09-17 | International Business Machines Corporation | Laser-assisted transdermal delivery of nanoparticulates and hydrogels |
US10029024B2 (en) * | 2013-09-06 | 2018-07-24 | Medaxis Ag | Handpiece for treating wounds |
US11224767B2 (en) | 2013-11-26 | 2022-01-18 | Sanuwave Health, Inc. | Systems and methods for producing and delivering ultrasonic therapies for wound treatment and healing |
USD733319S1 (en) | 2014-01-10 | 2015-06-30 | Celleration, Inc. | Ultrasonic treatment wand |
USD733321S1 (en) | 2014-01-10 | 2015-06-30 | Celleration, Inc. | Ultrasonic treatment device |
WO2015153172A1 (en) * | 2014-04-04 | 2015-10-08 | Photosonix Medical, Inc. | Methods, devices and systems for treating bacteria with mechanical stress energy and electromagnetic energy |
EP3131630B1 (en) | 2014-04-18 | 2023-11-29 | Ulthera, Inc. | Band transducer ultrasound therapy |
WO2016168385A2 (en) | 2015-04-14 | 2016-10-20 | Photosonix Medical, Inc. | Method and device for treatment with combination ultrasound-phototherapy transducer |
PL3405294T3 (en) | 2016-01-18 | 2023-05-08 | Ulthera, Inc. | Compact ultrasound device having annular ultrasound array peripherally electrically connected to flexible printed circuit board |
CN109414588A (en) * | 2016-04-14 | 2019-03-01 | 费尔德雷克卡罗鲁伊斯有限公司 | A kind of radiotherapy equipment comprising ion module and ultraviolet light source |
CN114631846A (en) | 2016-08-16 | 2022-06-17 | 奥赛拉公司 | System and method for cosmetic ultrasound treatment of skin |
CN106620970A (en) * | 2016-10-30 | 2017-05-10 | 田中枢 | Portable atomization and administration device |
KR20180061036A (en) * | 2016-11-29 | 2018-06-07 | 서울바이오시스 주식회사 | Liquid bandage hardening device for medical and method for hardening liquid bandage using the same |
WO2018101720A1 (en) * | 2016-11-29 | 2018-06-07 | 서울바이오시스주식회사 | Medical device for curing liquid bandage and method for curing liquid bandage using same |
KR101814995B1 (en) | 2017-04-13 | 2018-01-04 | 주식회사 씨엠랩 | Composite treatment cartridge and composite medical treatment apparatus having the same |
WO2019084600A1 (en) * | 2017-10-30 | 2019-05-09 | Helium 3 Resources Pty Ltd | A melanin production stimulating device and method of using same |
US11944849B2 (en) | 2018-02-20 | 2024-04-02 | Ulthera, Inc. | Systems and methods for combined cosmetic treatment of cellulite with ultrasound |
Family Cites Families (132)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3275059A (en) | 1965-05-10 | 1966-09-27 | Little Inc A | Nozzle system and fuel oil burner incorporating it |
US3392916A (en) | 1965-12-08 | 1968-07-16 | Carl Gunnar Daniel Engstrom | Ultrasonic atomizer |
US3561444A (en) | 1968-05-22 | 1971-02-09 | Bio Logics Inc | Ultrasonic drug nebulizer |
US3860173A (en) | 1970-02-03 | 1975-01-14 | Naoyasu Sata | Non-polluting combustion engine having ultrasonic fuel atomizer in place of carburetor |
US4085893A (en) | 1974-03-20 | 1978-04-25 | Durley Iii Benton A | Ultrasonic humidifiers, atomizers and the like |
GB1496086A (en) | 1975-02-19 | 1977-12-21 | Plessey Co Ltd | Vibratory atomizer |
US4309989A (en) | 1976-02-09 | 1982-01-12 | The Curators Of The University Of Missouri | Topical application of medication by ultrasound with coupling agent |
US4153201A (en) | 1976-11-08 | 1979-05-08 | Sono-Tek Corporation | Transducer assembly, ultrasonic atomizer and fuel burner |
US4301968A (en) | 1976-11-08 | 1981-11-24 | Sono-Tek Corporation | Transducer assembly, ultrasonic atomizer and fuel burner |
DE2811248C3 (en) | 1978-03-15 | 1981-11-26 | Bosch-Siemens Hausgeräte GmbH, 7000 Stuttgart | Liquid atomizer |
FR2443113B1 (en) | 1978-06-30 | 1985-12-06 | Deutsch Pruef Messgeraete | METHOD AND DEVICE FOR TRANSMITTING ACOUSTIC PULSES, PARTICULARLY IN THE FIELD OF ULTRA-SOUNDS, AND APPLICATION OF SUCH PULSES IN PARTICULAR TO NON-DESTRUCTIVE CONTROL OF MATERIALS |
GB2029270B (en) | 1978-07-11 | 1982-11-03 | Plessey Co Ltd | Vibratory atomiser |
DE2854841C2 (en) | 1978-12-19 | 1981-03-26 | Bosch-Siemens Hausgeräte GmbH, 7000 Stuttgart | Liquid atomizer, preferably inhalation device |
JPS5848225B2 (en) | 1979-01-09 | 1983-10-27 | オムロン株式会社 | Atomization amount control method of ultrasonic liquid atomization device |
DE7917568U1 (en) | 1979-06-19 | 1979-09-20 | Bosch-Siemens Hausgeraete Gmbh, 7000 Stuttgart | INHALATION DEVICE |
GB2058209B (en) | 1979-09-11 | 1983-04-27 | Plessey Co Ltd | Method of producing a fuel injector for an engine |
US4352459A (en) | 1979-11-13 | 1982-10-05 | Sono-Tek Corporation | Ultrasonic liquid atomizer having an axially-extending liquid feed passage |
NL8202263A (en) | 1981-06-06 | 1983-01-03 | Rowenta Werke Gmbh | ULTRASONORE RESPIRATOR. |
FR2507086B1 (en) | 1981-06-06 | 1986-06-27 | Rowenta Werke Gmbh | LIQUID PIPING DEVICE FOR ULTRASONIC INHALATORS OR SIMILAR APPARATUS |
DE3124854C2 (en) | 1981-06-24 | 1985-03-14 | Reinhard 8057 Eching Mühlbauer | High pressure injection system with ultrasonic atomization |
BR8107560A (en) | 1981-11-19 | 1983-07-05 | Luiz Romariz Duarte | ULTRASONIC STIMULATION OF BONE FRACTURE CONSOLIDATION |
US4655393A (en) | 1983-01-05 | 1987-04-07 | Sonotek Corporation | High volume ultrasonic liquid atomizer |
US4541564A (en) | 1983-01-05 | 1985-09-17 | Sono-Tek Corporation | Ultrasonic liquid atomizer, particularly for high volume flow rates |
GB8316051D0 (en) | 1983-06-13 | 1983-07-20 | Shell Int Research | Atomiser |
EP0156409A3 (en) | 1984-02-23 | 1986-06-25 | Jean Michel Anthony | Device for moistening parts of the human body |
JPS60222552A (en) | 1984-04-19 | 1985-11-07 | Toa Nenryo Kogyo Kk | Ultrasonic injection method and injection valve |
DE3574344D1 (en) | 1984-08-29 | 1989-12-28 | Omron Tateisi Electronics Co | Ultrasonic atomizer |
DE3582287D1 (en) | 1984-09-07 | 1991-05-02 | Omron Tateisi Electronics Co | VIBRATION GENERATOR FOR AN INHALATION DEVICE WITH ULTRASONIC SPRAYING. |
US4582654A (en) | 1984-09-12 | 1986-04-15 | Varian Associates, Inc. | Nebulizer particularly adapted for analytical purposes |
US4726523A (en) | 1984-12-11 | 1988-02-23 | Toa Nenryo Kogyo Kabushiki Kaisha | Ultrasonic injection nozzle |
JPS61138559A (en) | 1984-12-11 | 1986-06-26 | Toa Nenryo Kogyo Kk | Oscillator for ultrasonic wave injection nozzle |
JPS61138558A (en) | 1984-12-11 | 1986-06-26 | Toa Nenryo Kogyo Kk | Oscillator for ultrasonic wave injection nozzle |
JPS61259784A (en) | 1985-05-13 | 1986-11-18 | Toa Nenryo Kogyo Kk | Vibrator for ultrasonic injection |
US4642581A (en) | 1985-06-21 | 1987-02-10 | Sono-Tek Corporation | Ultrasonic transducer drive circuit |
US4659014A (en) | 1985-09-05 | 1987-04-21 | Delavan Corporation | Ultrasonic spray nozzle and method |
US4941618A (en) | 1986-07-07 | 1990-07-17 | Leeman Labs Inc. | Nebulizer employing a fine mesh screen |
DE3627222A1 (en) | 1986-08-11 | 1988-02-18 | Siemens Ag | ULTRASONIC POCKET SPRAYER |
US4930700A (en) | 1986-08-27 | 1990-06-05 | Atochem North America | Ultrasonic dispersion nozzle having internal shut-off mechanism with barrier fluid separation |
US5104042A (en) | 1986-08-27 | 1992-04-14 | Atochem North America, Inc. | Ultrasonic dispersion nozzle with internal shut-off mechanism having barrier-fluid separation means incorporated therewith |
US4850534A (en) | 1987-05-30 | 1989-07-25 | Tdk Corporation | Ultrasonic wave nebulizer |
US5040537A (en) | 1987-11-24 | 1991-08-20 | Hitachi, Ltd. | Method and apparatus for the measurement and medical treatment using an ultrasonic wave |
DE3741201A1 (en) | 1987-12-02 | 1989-06-15 | Schering Ag | ULTRASONIC PROCESS AND METHOD FOR IMPLEMENTING IT |
FI82808C (en) | 1987-12-31 | 1991-04-25 | Etelae Haemeen Keuhkovammayhdi | Ultraljudfinfördelningsanordning |
US4905671A (en) | 1988-01-11 | 1990-03-06 | Dornier Medizintechnik Gmbh | Inducement of bone growth by acoustic shock waves |
US5186162A (en) | 1988-09-14 | 1993-02-16 | Interpore Orthopaedics, Inc. | Ultrasonic transducer device for treatment of living tissue and/or cells |
US5211160A (en) | 1988-09-14 | 1993-05-18 | Interpore Orthopaedics, Inc. | Ultrasonic orthopedic treatment head and body-mounting means therefor |
EP0373237A1 (en) | 1988-12-13 | 1990-06-20 | Siemens Aktiengesellschaft | Pocket inhaler device |
JPH03505424A (en) | 1989-04-14 | 1991-11-28 | アゼルバイジャンスキ ポリテフニチェスキ インスティテュト イメニ チェー.イルドリマ | Ultrasonic atomization device for liquid media |
US5002059A (en) | 1989-07-26 | 1991-03-26 | Boston Scientific Corporation | Tip filled ultrasound catheter |
US5163433A (en) | 1989-11-01 | 1992-11-17 | Olympus Optical Co., Ltd. | Ultrasound type treatment apparatus |
US4961885A (en) | 1989-11-24 | 1990-10-09 | Elecsys Ltd. | Ultrasonic nebulizer |
FR2655279B1 (en) | 1989-12-01 | 1993-09-17 | Anios Lab Sarl | PROCESS FOR MICRO-SPRAYING AN ULTRA-SOUND SOLUTION AND MICRO-DROPLET DIFFUSER IMPLEMENTING SAID DEVICE. |
US5115805A (en) | 1990-02-23 | 1992-05-26 | Cygnus Therapeutic Systems | Ultrasound-enhanced delivery of materials into and through the skin |
US5231975A (en) | 1990-02-23 | 1993-08-03 | Cygnus Therapeutic Systems | Ultrasound-enhanced delivery of materials into and through the skin |
US5197946A (en) | 1990-06-27 | 1993-03-30 | Shunro Tachibana | Injection instrument with ultrasonic oscillating element |
GB9015077D0 (en) | 1990-07-09 | 1990-08-29 | Riker Laboratories Inc | Inhaler |
US5172692A (en) | 1990-12-05 | 1992-12-22 | Kulow Howard H | Method for inflammatory response management |
US5269291A (en) | 1990-12-10 | 1993-12-14 | Coraje, Inc. | Miniature ultrasonic transducer for plaque ablation |
US5324255A (en) | 1991-01-11 | 1994-06-28 | Baxter International Inc. | Angioplasty and ablative devices having onboard ultrasound components and devices and methods for utilizing ultrasound to treat or prevent vasopasm |
US5316000A (en) | 1991-03-05 | 1994-05-31 | Technomed International (Societe Anonyme) | Use of at least one composite piezoelectric transducer in the manufacture of an ultrasonic therapy apparatus for applying therapy, in a body zone, in particular to concretions, to tissue, or to bones, of a living being and method of ultrasonic therapy |
WO1994016759A1 (en) | 1991-03-05 | 1994-08-04 | Miris Medical Corporation | An automatic aerosol medication delivery system and methods |
CA2063529A1 (en) | 1991-03-22 | 1992-09-23 | Katsuro Tachibana | Booster for therapy of diseases with ultrasound and pharmaceutical liquid composition containing the same |
US5325860A (en) | 1991-11-08 | 1994-07-05 | Mayo Foundation For Medical Education And Research | Ultrasonic and interventional catheter and method |
GB2265845B (en) | 1991-11-12 | 1996-05-01 | Medix Ltd | A nebuliser and nebuliser control system |
US5374266A (en) | 1991-11-27 | 1994-12-20 | Kabushiki Kaisha Morita Seisakusho | Medical laser treatment device |
US5529572A (en) | 1992-01-24 | 1996-06-25 | Medispec Ltd. | Method and apparatus particularly useful for treating osteoporosis |
US5993389A (en) | 1995-05-22 | 1999-11-30 | Ths International, Inc. | Devices for providing acoustic hemostasis |
US5362309A (en) | 1992-09-14 | 1994-11-08 | Coraje, Inc. | Apparatus and method for enhanced intravascular phonophoresis including dissolution of intravascular blockage and concomitant inhibition of restenosis |
US5318014A (en) | 1992-09-14 | 1994-06-07 | Coraje, Inc. | Ultrasonic ablation/dissolution transducer |
US5393296A (en) | 1992-12-09 | 1995-02-28 | Siemens Aktiengesellschaft | Method for the medical treatment of pathologic bone |
US5573497A (en) | 1994-11-30 | 1996-11-12 | Technomed Medical Systems And Institut National | High-intensity ultrasound therapy method and apparatus with controlled cavitation effect and reduced side lobes |
US6098620A (en) | 1993-01-29 | 2000-08-08 | Aradigm Corporation | Device for aerosolizing narcotics |
US5558085A (en) | 1993-01-29 | 1996-09-24 | Aradigm Corporation | Intrapulmonary delivery of peptide drugs |
US5707403A (en) | 1993-02-24 | 1998-01-13 | Star Medical Technologies, Inc. | Method for the laser treatment of subsurface blood vessels |
US5527350A (en) | 1993-02-24 | 1996-06-18 | Star Medical Technologies, Inc. | Pulsed infrared laser treatment of psoriasis |
DE4315282C2 (en) | 1993-05-07 | 1999-10-07 | Siemens Ag | Use of an acoustic pressure pulse source |
JP3553599B2 (en) | 1993-06-29 | 2004-08-11 | インジェット ディジタル エアロソルズ リミテッド | dispenser |
CH686872A5 (en) | 1993-08-09 | 1996-07-31 | Disetronic Ag | Medical Inhalationsgeraet. |
GB9324250D0 (en) | 1993-11-25 | 1994-01-12 | Minnesota Mining & Mfg | Inhaler |
EP0657226B1 (en) | 1993-12-10 | 1998-02-04 | Siemens Aktiengesellschaft | Ultrasonic sprayer |
US5570682A (en) | 1993-12-14 | 1996-11-05 | Ethex International, Inc. | Passive inspiratory nebulizer system |
JPH07184907A (en) | 1993-12-28 | 1995-07-25 | Toshiba Corp | Ultrasonic treating device |
US5989245A (en) | 1994-03-21 | 1999-11-23 | Prescott; Marvin A. | Method and apparatus for therapeutic laser treatment |
US5616140A (en) | 1994-03-21 | 1997-04-01 | Prescott; Marvin | Method and apparatus for therapeutic laser treatment |
US5437606A (en) | 1994-03-28 | 1995-08-01 | Tsukamoto; Kenichi | Ultrasonic system to alleviate toothaches |
US5516043A (en) | 1994-06-30 | 1996-05-14 | Misonix Inc. | Ultrasonic atomizing device |
US6113570A (en) | 1994-09-09 | 2000-09-05 | Coraje, Inc. | Method of removing thrombosis in fistulae |
US5547459A (en) | 1994-10-25 | 1996-08-20 | Orthologic Corporation | Ultrasonic bone-therapy apparatus and method |
US5520612A (en) | 1994-12-30 | 1996-05-28 | Exogen, Inc. | Acoustic system for bone-fracture therapy |
US5556372A (en) | 1995-02-15 | 1996-09-17 | Exogen, Inc. | Apparatus for ultrasonic bone treatment |
US5626554A (en) | 1995-02-21 | 1997-05-06 | Exogen, Inc. | Gel containment structure |
US6014970A (en) | 1998-06-11 | 2000-01-18 | Aerogen, Inc. | Methods and apparatus for storing chemical compounds in a portable inhaler |
US5554172A (en) | 1995-05-09 | 1996-09-10 | The Larren Corporation | Directed energy surgical method and assembly |
US5730705A (en) | 1995-06-12 | 1998-03-24 | Talish; Roger J. | Ultrasonic treatment for bony ingrowth |
US5879376A (en) | 1995-07-12 | 1999-03-09 | Luxar Corporation | Method and apparatus for dermatology treatment |
US5658323A (en) | 1995-07-12 | 1997-08-19 | Miller; Iain D. | Method and apparatus for dermatology treatment |
US5947921A (en) | 1995-12-18 | 1999-09-07 | Massachusetts Institute Of Technology | Chemical and physical enhancers and ultrasound for transdermal drug delivery |
US6041253A (en) | 1995-12-18 | 2000-03-21 | Massachusetts Institute Of Technology | Effect of electric field and ultrasound for transdermal drug delivery |
US5735811A (en) | 1995-11-30 | 1998-04-07 | Pharmasonics, Inc. | Apparatus and methods for ultrasonically enhanced fluid delivery |
US5683432A (en) | 1996-01-11 | 1997-11-04 | Medtronic, Inc. | Adaptive, performance-optimizing communication system for communicating with an implanted medical device |
JP3930052B2 (en) | 1996-02-15 | 2007-06-13 | バイオセンス・インコーポレイテッド | Catheter-based surgery |
US5762616A (en) | 1996-03-15 | 1998-06-09 | Exogen, Inc. | Apparatus for ultrasonic treatment of sites corresponding to the torso |
US5656016A (en) | 1996-03-18 | 1997-08-12 | Abbott Laboratories | Sonophoretic drug delivery system |
US5746756A (en) | 1996-06-03 | 1998-05-05 | Ethicon Endo-Surgery, Inc. | Internal ultrasonic tip amplifier |
US5699805A (en) | 1996-06-20 | 1997-12-23 | Mayo Foundation For Medical Education And Research | Longitudinal multiplane ultrasound transducer underfluid catheter system |
US6234990B1 (en) | 1996-06-28 | 2001-05-22 | Sontra Medical, Inc. | Ultrasound enhancement of transdermal transport |
US6024718A (en) | 1996-09-04 | 2000-02-15 | The Regents Of The University Of California | Intraluminal directed ultrasound delivery device |
US5835678A (en) | 1996-10-03 | 1998-11-10 | Emcore Corporation | Liquid vaporizer system and method |
EP0957980A4 (en) | 1996-11-27 | 2000-03-29 | Gen Hospital Corp | Compound delivery using impulse transients |
US5785972A (en) | 1997-01-10 | 1998-07-28 | Tyler; Kathleen A. | Colloidal silver, honey, and helichrysum oil antiseptic composition and method of application |
US5904659A (en) | 1997-02-14 | 1999-05-18 | Exogen, Inc. | Ultrasonic treatment for wounds |
ATE258453T1 (en) | 1997-04-18 | 2004-02-15 | Exogen Inc | DEVICE FOR ULTRASONIC BONE TREATMENT |
WO1998048711A1 (en) | 1997-05-01 | 1998-11-05 | Ekos Corporation | Ultrasound catheter |
DE19718513C5 (en) | 1997-05-02 | 2010-06-02 | Sanuwave, Inc., | Device for generating acoustic shock waves, in particular for medical use |
US5879314A (en) | 1997-06-30 | 1999-03-09 | Cybersonics, Inc. | Transducer assembly and method for coupling ultrasonic energy to a body for thrombolysis of vascular thrombi |
DE19733838C2 (en) | 1997-08-04 | 2001-06-13 | Hmt Ag | Device for treatment with acoustic shock waves |
US6113558A (en) | 1997-09-29 | 2000-09-05 | Angiosonics Inc. | Pulsed mode lysis method |
US5954047A (en) | 1997-10-17 | 1999-09-21 | Systemic Pulmonary Development, Ltd. | Methods and apparatus for delivering aerosolized medication |
US6325769B1 (en) | 1998-12-29 | 2001-12-04 | Collapeutics, Llc | Method and apparatus for therapeutic treatment of skin |
US6190315B1 (en) | 1998-01-08 | 2001-02-20 | Sontra Medical, Inc. | Sonophoretic enhanced transdermal transport |
US6158431A (en) | 1998-02-13 | 2000-12-12 | Tsi Incorporated | Portable systems and methods for delivery of therapeutic material to the pulmonary system |
US6102298A (en) | 1998-02-23 | 2000-08-15 | The Procter & Gamble Company | Ultrasonic spray coating application system |
US6206842B1 (en) | 1998-08-03 | 2001-03-27 | Lily Chen Tu | Ultrasonic operation device |
US6106547A (en) | 1998-09-22 | 2000-08-22 | Huei-Jung; Lien | Hot/cold dual-mold skin treatment apparatus |
US6061597A (en) | 1998-12-18 | 2000-05-09 | Robert D. Rieman | Method and device for healing bone fractures |
US6231528B1 (en) | 1999-01-15 | 2001-05-15 | Jonathan J. Kaufman | Ultrasonic and growth factor bone-therapy: apparatus and method |
US6206843B1 (en) | 1999-01-28 | 2001-03-27 | Ultra Cure Ltd. | Ultrasound system and methods utilizing same |
JP2000237275A (en) | 1999-02-24 | 2000-09-05 | Ya Man Ltd | Ultrasonic mist generating apparatus |
ES2240078T3 (en) * | 1999-03-09 | 2005-10-16 | Thermage, Inc. | APPARATUS FOR TREATMENT OF FABRICS. |
AU3440901A (en) * | 1999-12-07 | 2001-06-18 | Board Of Trustees Of The University Of Arkansas, The | Laser directed portable mri stereotactic system |
US6601581B1 (en) * | 2000-11-01 | 2003-08-05 | Advanced Medical Applications, Inc. | Method and device for ultrasound drug delivery |
US6533803B2 (en) * | 2000-12-22 | 2003-03-18 | Advanced Medical Applications, Inc. | Wound treatment method and device with combination of ultrasound and laser energy |
-
2003
- 2003-02-14 US US10/366,787 patent/US6761729B2/en not_active Expired - Lifetime
-
2004
- 2004-02-03 CA CA002516190A patent/CA2516190A1/en not_active Abandoned
- 2004-02-03 WO PCT/US2004/002962 patent/WO2004089469A1/en active Application Filing
- 2004-02-03 EP EP04707726A patent/EP1596940A1/en not_active Withdrawn
- 2004-02-03 JP JP2005518573A patent/JP2006517810A/en active Pending
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JP2006517810A (en) | 2006-08-03 |
US20030153961A1 (en) | 2003-08-14 |
US6761729B2 (en) | 2004-07-13 |
EP1596940A1 (en) | 2005-11-23 |
WO2004089469A1 (en) | 2004-10-21 |
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