CA2481627A1 - Method and device for continuous monitoring of the concentration of an analyte - Google Patents

Method and device for continuous monitoring of the concentration of an analyte Download PDF

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Publication number
CA2481627A1
CA2481627A1 CA002481627A CA2481627A CA2481627A1 CA 2481627 A1 CA2481627 A1 CA 2481627A1 CA 002481627 A CA002481627 A CA 002481627A CA 2481627 A CA2481627 A CA 2481627A CA 2481627 A1 CA2481627 A1 CA 2481627A1
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Canada
Prior art keywords
signal
measurement
filter algorithm
concentration
time
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Granted
Application number
CA002481627A
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French (fr)
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CA2481627C (en
Inventor
Reinhard Kotulla
Arnulf Staib
Ralph Gillen
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of CA2481627A1 publication Critical patent/CA2481627A1/en
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Publication of CA2481627C publication Critical patent/CA2481627C/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14503—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02—Operational features
    • A61B2560/0223—Operational features of calibration, e.g. protocols for calibrating sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
    • A61B5/7207—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal of noise induced by motion artifacts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7239—Details of waveform analysis using differentiation including higher order derivatives

Abstract

A method for continuous monitoring of the concentration of an analyte by determining its change over time in the living body of a human or animal, in which at sequential points in time, measurement values of a measurement variable correlating with the desired concentration are measured as the measurement signal (z t) and the change over time of the concentration is determined from the measurement signal as the useful signal (y t) using a calibration, the determination of the useful signal (y t) from the measurement signal (z t) including a filter algorithm in the time domain, by which errors of the useful signal, which result from noise contained in the measurement signal, are reduced, and the filter algorithm including an operation in which the influence of an actual measurement value on the useful signal is weighted using a weighting factor (V). During the continuous monitoring, a signal variation parameter (.sigma.t) is determined on the basis of signal variations detected in close chronological relationship with the measurement of the actual measurement value. The weighting factor is dynamically adapted as a function of the signal variation parameter determined for the point in time of the actual measurement.

Claims (8)

1. A method for continuous monitoring of the concentration of an analyte by determining its change over time in the living body of a human or animal, in which, at sequential points in time, measurement values of a measurement variable correlating with the desired concentration are measured as a measurement signal (z t) and the change over time of the concentration is determined from the measurement signal as a useful signal (y t) by means of a calibration, wherein the determination of the useful signal (y t) from the measurement signal (z t) includes a filter algorithm in the time domain, by which errors of the useful signal resulting from noise contained in the measurement signal, are reduced, and the filter algorithm includes an operation in which the influence of an actual measurement value on the useful signal is weighted by means of a weighting factor (V), characterized in that, during the continuous monitoring, a signal variation parameter (.sigma.t) is determined on the basis of signal variations detected in close chronological relation to the measurement of the actual measurement value and the weighting factor is dynamically adapted as a function of the signal variation parameter determined for the point in time of the actual measurement.
2. The method according to Claim 1, characterized in that measurement values, which were measured less than 30 minutes, preferably less than 15 minutes, and especially preferably less than 5 minutes before the measurement of the actual measurement value, are used in the determination of the signal variations.
3. The method according to one of the preceding claims, characterized in that the filter algorithm is a recursive filter algorithm.
4. The method according to Claim 3, characterized in that the filter algorithm is a Kalman filter algorithm.
5. The method according to Claim 4, characterized in that the filter algorithm is a linear Kalman filter algorithm.
6. The method according to any one of Claims 1 to 5, characterized in that the variables of a system model upon which the filter algorithm is based comprise a check variable.
7. The method according to Claim 5, characterized in that the check variable is a time derivative, preferably the first time derivative of the analyte concentration.
8. A device for continuous monitoring of the concentration of an analyte by determining its change over time in the living body of a human or animal, comprising a measurement unit (12), by which measurement values of a measurement variable correlating with the desired concentration are measured as the measurement signal (z t) at sequential points in time, and comprising an analysis unit (3), by which the change over time of the concentration is determined by means of a calibration as a useful signal (y t) from the measurement signal, the determination of the useful signal (y t) from the measurement signal (z t) includes a filter algorithm in the time domain, by which errors of the useful signal, which result from noise contained in the measurement signal, are reduced, and the filter algorithm includes operations, in which the influence of an actual measurement value on the useful signal is weighted using a weighting factor (V), characterized in that, during the continuous monitoring, a signal variation parameter (.sigma.t) is determined on the basis of signal variations detected in close chronological relationship with the measurement of the actual measurement value, and the weighting factor is dynamically adapted as a function of the signal variation parameter determined for the point in time of the actual measurement.
CA002481627A 2003-09-23 2004-09-15 Method and device for continuous monitoring of the concentration of an analyte Active CA2481627C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10343863A DE10343863A1 (en) 2003-09-23 2003-09-23 Method and device for continuously monitoring the concentration of an analyte
DE10343863.7 2003-09-23

Publications (2)

Publication Number Publication Date
CA2481627A1 true CA2481627A1 (en) 2005-03-23
CA2481627C CA2481627C (en) 2009-12-29

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA002481627A Active CA2481627C (en) 2003-09-23 2004-09-15 Method and device for continuous monitoring of the concentration of an analyte

Country Status (7)

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US (3) US20050272985A1 (en)
EP (1) EP1518495B1 (en)
JP (1) JP4040614B2 (en)
AT (1) ATE462350T1 (en)
CA (1) CA2481627C (en)
DE (2) DE10343863A1 (en)
ES (1) ES2340383T3 (en)

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