CA2464670A1 - Transdermal transport device with suction - Google Patents

Transdermal transport device with suction Download PDF

Info

Publication number
CA2464670A1
CA2464670A1 CA002464670A CA2464670A CA2464670A1 CA 2464670 A1 CA2464670 A1 CA 2464670A1 CA 002464670 A CA002464670 A CA 002464670A CA 2464670 A CA2464670 A CA 2464670A CA 2464670 A1 CA2464670 A1 CA 2464670A1
Authority
CA
Canada
Prior art keywords
needle
transport device
needles
suction
transdermal transport
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002464670A
Other languages
French (fr)
Other versions
CA2464670C (en
Inventor
Aimee B. Angel
Ian W. Hunter
Peter Hansen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute Of Technology
Aimee B. Angel
Ian W. Hunter
Peter Hansen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Institute Of Technology, Aimee B. Angel, Ian W. Hunter, Peter Hansen filed Critical Massachusetts Institute Of Technology
Publication of CA2464670A1 publication Critical patent/CA2464670A1/en
Application granted granted Critical
Publication of CA2464670C publication Critical patent/CA2464670C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/155—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by gas introduced into the reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/46—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for controlling depth of insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M2005/1401—Functional features
    • A61M2005/1405—Patient controlled analgesia [PCA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M2005/14204—Pressure infusion, e.g. using pumps with gas-producing electrochemical cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • A61M2005/14252—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type with needle insertion means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M2005/14268—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body with a reusable and a disposable component
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • A61M2005/1581—Right-angle needle-type devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0038—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/02—General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0266—Shape memory materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8206—Internal energy supply devices battery-operated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/65—Impedance, e.g. conductivity, capacity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/42—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced
    • A61M5/425—Protruding skin to facilitate piercing, e.g. vacuum cylinders, vein immobilising means

Abstract

A transdermal transport device includes a reservoir for holding a formulatio n of an active principle, and one or more needles (14). Each needle has a bore through which the formulation is transported between the reservoir and a biological body, and has an end portion that is substantially algined in a plane parallel to a surfaceof the biological body when the device is placed on the surface. The device also includes a vaccum generator (28) which creates a suction to draw a portion of the surface beyond the plane of the end portion s to enable the end portions to penetrate the portion of the surface as the needles are translated along an axis that is substantially parallel to the plane.

Claims (10)

1. A transdermal transport device, comprising:
a reservoir for holding a formulation of an active principle;
one or more needles, each needle having a bore through which the formulation is transported between the reservoir and a biological body, each needle having an end portion that is substantially aligned in a plane parallel to a surface of the biological body when the device is placed on the surface;
and a vacuum generator which creates a suction to draw a portion of the surface beyond the of the end portions to enable the end portions to penetrate the portion of the surface as the needles are translated along an axis that is substantially parallel to the plane.
2. The transdermal transport device of claim 1 wherein the vacuum is used to secure the device to the surface of the body.
3. The transdermal transport device of claim 2 wherein the vacuum is turned off after the needles penetrate the skin.
4. The transdermal transport device of claim 1 wherein the needles are rotated about an axis that is substantially perpendicular to the plane.
5. The transdermal transport device of claim 1 further comprising a mechanical stop to limit the depth of needle penetration.
6. A transdermal transport device, comprising:
a means for holding a formulation of an active principle;
a needle to transport the formulation between the means for holding the liquid formulation and a target area of a biological body;
a means for creating a suction to draw a portion of the target area towards the needle to facilitate penetrating the portion of the target area with the needle; and a mechanical stop to limit the depth of needle penetration.
7. A method of transdermally transporting a formulation of an active principle, comprising:
generating a suction to draw a portion of a target area of a biological body towards an array of needles of a transdermal transport device, each needle have an end portion which is substantially aligned in a plane parallel to a surface of the biological body; and driving the end portions into the portion of the target area.
8. The method of claim 7, wherein the suction secures the device to the surface of the body.
9. The method of claim 8, further comprising turning off the suction after the end portions have penetrated the portion of the target area.
10. The method of claim 7, wherein driving includes rotating the end portions of the needles about an axis that is substantially perpendicular to the plane that is parallel to the surface of the biological body.
CA2464670A 2001-10-26 2002-10-22 Transdermal transport device with suction Expired - Fee Related CA2464670C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US33842501P 2001-10-26 2001-10-26
US60/338,425 2001-10-26
US39948902P 2002-07-29 2002-07-29
US60/399,489 2002-07-29
PCT/US2002/033830 WO2003037407A1 (en) 2001-10-26 2002-10-22 Transdermal transport device with suction

Publications (2)

Publication Number Publication Date
CA2464670A1 true CA2464670A1 (en) 2003-05-08
CA2464670C CA2464670C (en) 2011-04-26

Family

ID=26991185

Family Applications (5)

Application Number Title Priority Date Filing Date
CA2464483A Expired - Fee Related CA2464483C (en) 2001-10-26 2002-10-18 Microneedle transport device
CA2464485A Expired - Fee Related CA2464485C (en) 2001-10-26 2002-10-21 Microneedle transdermal transport device
CA2464670A Expired - Fee Related CA2464670C (en) 2001-10-26 2002-10-22 Transdermal transport device with suction
CA2464673A Expired - Fee Related CA2464673C (en) 2001-10-26 2002-10-22 Impedance sensor
CA002464487A Abandoned CA2464487A1 (en) 2001-10-26 2002-10-22 Transdermal transport device with an electrolytic actuator

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CA2464483A Expired - Fee Related CA2464483C (en) 2001-10-26 2002-10-18 Microneedle transport device
CA2464485A Expired - Fee Related CA2464485C (en) 2001-10-26 2002-10-21 Microneedle transdermal transport device

Family Applications After (2)

Application Number Title Priority Date Filing Date
CA2464673A Expired - Fee Related CA2464673C (en) 2001-10-26 2002-10-22 Impedance sensor
CA002464487A Abandoned CA2464487A1 (en) 2001-10-26 2002-10-22 Transdermal transport device with an electrolytic actuator

Country Status (8)

Country Link
US (7) US7429258B2 (en)
EP (5) EP1439871B1 (en)
JP (10) JP2005525141A (en)
AT (3) ATE420680T1 (en)
AU (3) AU2002353840B2 (en)
CA (5) CA2464483C (en)
DE (3) DE60230896D1 (en)
WO (5) WO2003037403A1 (en)

Families Citing this family (392)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6461292B1 (en) 1999-08-12 2002-10-08 Obtech Medical Ag Anal incontinence treatment with wireless energy supply
US6482145B1 (en) 2000-02-14 2002-11-19 Obtech Medical Ag Hydraulic anal incontinence treatment
US6464628B1 (en) 1999-08-12 2002-10-15 Obtech Medical Ag Mechanical anal incontinence
US6471635B1 (en) 2000-02-10 2002-10-29 Obtech Medical Ag Anal incontinence disease treatment with controlled wireless energy supply
DE60113965T2 (en) 2000-02-10 2006-07-06 Potencia Medical Ag TREATMENT OF HARNINE CONTINENCE WITH WIRELESS ENERGY SUPPLY
CN1698552B (en) 2000-02-10 2010-05-12 厄罗洛吉卡股份公司 Controlled urinary incontinence treatment
WO2001047434A2 (en) 2000-02-10 2001-07-05 Potencia Medical Ag Mechanical impotence treatment apparatus
DE60136910D1 (en) 2000-02-11 2009-01-22 Potentica Ag DEVICE WITH ENERGY CONVERSION DEVICES FOR IMPOTENA TREATMENT
CA2396224C (en) 2000-02-11 2011-07-12 Potencia Medical Ag Controlled impotence treatment
US20030100929A1 (en) 2000-02-14 2003-05-29 Peter Forsell Controlled penile prosthesis
US7442165B2 (en) 2000-02-14 2008-10-28 Obtech Medical Ag Penile prosthesis
CA2397284C (en) 2000-02-14 2010-05-18 Potencia Medical Ag Male impotence prosthesis apparatus with wireless energy supply
US7419481B2 (en) * 2000-10-13 2008-09-02 Alza Corporation Apparatus and method for piercing skin with microprotrusions
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
DE60207902T2 (en) * 2001-01-30 2006-06-14 Nissan Chemical Ind Ltd Isocyanurate compound and process for its preparation
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
US7025774B2 (en) * 2001-06-12 2006-04-11 Pelikan Technologies, Inc. Tissue penetration device
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US6966880B2 (en) * 2001-10-16 2005-11-22 Agilent Technologies, Inc. Universal diagnostic platform
US7429258B2 (en) * 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
US7858112B2 (en) * 2002-02-28 2010-12-28 Lintec Corporation Percutaneous absorption system and percutaneous absorption method
US7115108B2 (en) * 2002-04-02 2006-10-03 Becton, Dickinson And Company Method and device for intradermally delivering a substance
US6912417B1 (en) 2002-04-05 2005-06-28 Ichor Medical Systmes, Inc. Method and apparatus for delivery of therapeutic agents
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8784335B2 (en) * 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US9795334B2 (en) * 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7226461B2 (en) 2002-04-19 2007-06-05 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with sterility barrier release
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US20040039289A1 (en) * 2002-04-30 2004-02-26 Christensen Lars Hofmann Needle insertion sensor
EP3375463A1 (en) 2002-05-06 2018-09-19 Becton, Dickinson and Company Method and device for controlling drug pharmacokinetics
EP1389476A1 (en) * 2002-08-14 2004-02-18 Precimedix S.A. Programming device for a pump for injecting medicaments
JP2005537054A (en) * 2002-08-30 2005-12-08 ベクトン・ディキンソン・アンド・カンパニー Methods for controlling the pharmacokinetics of immunomodulatory compounds
US20120296233A9 (en) * 2002-09-05 2012-11-22 Freeman Dominique M Methods and apparatus for an analyte detecting device
JP2005537907A (en) 2002-09-06 2005-12-15 マサチューセッツ・インスティテュート・オブ・テクノロジー Biological property measuring apparatus and method
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
RU2004132832A (en) * 2003-03-06 2005-08-27 Лайфскен, Инк. (Us) SYSTEM AND METHOD FOR PUNCTING DERMAL TISSUE
WO2006001797A1 (en) * 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
EP1644004A4 (en) 2003-06-20 2010-10-06 Ronald Aung-Din Tropical therapy for the treatment of migraines, muscle sprains, muscle spasm, spasticity and related conditions
WO2005016441A1 (en) * 2003-08-04 2005-02-24 Alza Corporation Method and device for enhancing transdermal agent flux
EP1671096A4 (en) 2003-09-29 2009-09-16 Pelikan Technologies Inc Method and apparatus for an improved sample capture device
WO2005037095A1 (en) 2003-10-14 2005-04-28 Pelikan Technologies, Inc. Method and apparatus for a variable user interface
EP1527792A1 (en) 2003-10-27 2005-05-04 Novo Nordisk A/S Medical injection device mountable to the skin
ES2377647T3 (en) * 2003-10-31 2012-03-29 Alza Corporation Self-acting applicator for microprojection ordering
US7361182B2 (en) 2003-12-19 2008-04-22 Lightnix, Inc. Medical lancet
US8224410B2 (en) 2003-12-22 2012-07-17 Hadvary Paul Dermally affixed sensor device
CA2552385C (en) * 2003-12-29 2013-07-23 3M Innovative Properties Company Medical devices and kits including same
US8668656B2 (en) 2003-12-31 2014-03-11 Sanofi-Aventis Deutschland Gmbh Method and apparatus for improving fluidic flow and sample capture
CN1997423B (en) 2004-03-08 2012-10-03 艾科医疗系统公司 Improved apparatus for electrically mediated delivery of therapeutic agents
CA2562643A1 (en) * 2004-04-12 2005-11-24 Allergan, Inc. Multi-site injection system
WO2005118060A2 (en) * 2004-04-30 2005-12-15 Boston Scientific Limited Apparatus with partially insulated needle for measuring tissue impedance and method using same
EP1751546A2 (en) 2004-05-20 2007-02-14 Albatros Technologies GmbH & Co. KG Printable hydrogel for biosensors
WO2005120365A1 (en) * 2004-06-03 2005-12-22 Pelikan Technologies, Inc. Method and apparatus for a fluid sampling device
US9775553B2 (en) * 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
US7872396B2 (en) 2004-06-14 2011-01-18 Massachusetts Institute Of Technology Electrochemical actuator
US8247946B2 (en) 2004-06-14 2012-08-21 Massachusetts Institute Of Technology Electrochemical actuator
WO2005124918A2 (en) 2004-06-14 2005-12-29 Massachusetts Institute Of Technology Electrochemical actuating methods, devices and structures
US7789913B2 (en) * 2004-06-29 2010-09-07 Spine Wave, Inc. Methods for injecting a curable biomaterial into an intervertebral space
US20060030811A1 (en) * 2004-08-03 2006-02-09 Wong Patrick S Method and device for enhancing transdermal agent flux
US8696619B2 (en) * 2004-08-10 2014-04-15 Robert P. Schnall Drug delivery devices
EP2289646B1 (en) 2004-08-16 2014-02-12 Functional Microstructures Limited Device to be applied to a biological barrier
AU2005284908B2 (en) 2004-09-13 2011-12-08 Morningside Venture Investments Limited Biosynchronous transdermal drug delivery
US8252321B2 (en) 2004-09-13 2012-08-28 Chrono Therapeutics, Inc. Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like
EP2388078B1 (en) 2004-11-18 2013-03-20 3M Innovative Properties Co. Method of contact coating a microneedle array
AU2005306426B2 (en) * 2004-11-18 2011-04-28 3M Innovative Properties Company Masking method for coating a microneedle array
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
ATE504328T1 (en) 2004-11-18 2011-04-15 3M Innovative Properties Co MICRONEEDLE ARRANGEMENT APPLICATOR AND HOLDER
WO2006055795A1 (en) * 2004-11-18 2006-05-26 3M Innovative Properties Company Low-profile microneedle array applicator
US20080009801A1 (en) * 2004-12-02 2008-01-10 Nickel Janice H Method for dispensing material into a drug delivery device
CN100367906C (en) * 2004-12-08 2008-02-13 圣美迪诺医疗科技(湖州)有限公司 Endermic implantating biological sensors
US7833189B2 (en) 2005-02-11 2010-11-16 Massachusetts Institute Of Technology Controlled needle-free transport
US7850645B2 (en) 2005-02-11 2010-12-14 Boston Scientific Scimed, Inc. Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power
EP1709989A1 (en) * 2005-04-04 2006-10-11 Christoph Burckhardt AG Tattoo machine
EP1709906A1 (en) * 2005-04-07 2006-10-11 F. Hoffmann-La Roche Ag Method and device for blood sampling
JP5301985B2 (en) * 2005-04-07 2013-09-25 スリーエム イノベイティブ プロパティズ カンパニー System and method for tool feedback sensing
WO2006108809A1 (en) 2005-04-13 2006-10-19 Novo Nordisk A/S Medical skin mountable device and system
CA2609351C (en) * 2005-05-24 2015-01-06 Chrono Therapeutics Inc. Portable drug delivery device
WO2006127905A2 (en) 2005-05-24 2006-11-30 Chrono Therapeutics, Inc. Portable drug delivery device
US20080269666A1 (en) * 2005-05-25 2008-10-30 Georgia Tech Research Corporation Microneedles and Methods for Microinfusion
EP1884259A4 (en) * 2005-05-27 2011-03-30 Olympus Corp Device for introduction into subject
US8505544B2 (en) * 2005-05-31 2013-08-13 The Board Of Trustees Of The Leland Stanford Junior University Optically-implemented microsurgery system and approach
US9457147B2 (en) 2005-06-16 2016-10-04 Novo Nordisk A/S Method and apparatus for assisting patients in self-administration of medication
US20080195035A1 (en) 2005-06-24 2008-08-14 Frederickson Franklyn L Collapsible Patch and Method of Application
EP2474338B1 (en) 2005-06-27 2013-07-24 3M Innovative Properties Company Microneedle array applicator device
AU2006264300B2 (en) 2005-07-06 2012-03-08 Vascular Pathways Inc. Intravenous catheter insertion device and method of use
IL175460A (en) 2006-05-07 2011-05-31 Doron Aurbach Drug delivery device
US9687186B2 (en) 2005-07-21 2017-06-27 Steadymed Ltd. Drug delivery device
US10548659B2 (en) 2006-01-17 2020-02-04 Ulthera, Inc. High pressure pre-burst for improved fluid delivery
US8518069B2 (en) 2005-09-07 2013-08-27 Cabochon Aesthetics, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9358033B2 (en) 2005-09-07 2016-06-07 Ulthera, Inc. Fluid-jet dissection system and method for reducing the appearance of cellulite
US9011473B2 (en) 2005-09-07 2015-04-21 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9486274B2 (en) 2005-09-07 2016-11-08 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US20070185432A1 (en) * 2005-09-19 2007-08-09 Transport Pharmaceuticals, Inc. Electrokinetic system and method for delivering methotrexate
US20070066934A1 (en) * 2005-09-19 2007-03-22 Transport Pharmaceuticals, Inc. Electrokinetic delivery system and methods therefor
JP4935286B2 (en) * 2005-10-12 2012-05-23 パナソニック株式会社 Blood sensor
CN101291697B (en) 2005-10-17 2011-05-18 诺沃-诺迪斯克有限公司 Vented drug reservoir unit
ES2383650T3 (en) * 2005-11-02 2012-06-25 Injectica Ag Perfusion device with extensible and retractable needle, susceptible to implantation
US9248317B2 (en) 2005-12-02 2016-02-02 Ulthera, Inc. Devices and methods for selectively lysing cells
US7885793B2 (en) 2007-05-22 2011-02-08 International Business Machines Corporation Method and system for developing a conceptual model to facilitate generating a business-aligned information technology solution
US9636035B2 (en) * 2005-12-14 2017-05-02 Scibase Ab Medical apparatus for determination of biological conditions using impedance measurements
JP4402648B2 (en) * 2005-12-16 2010-01-20 オリンパス株式会社 Intra-subject introduction device
US7736310B2 (en) 2006-01-30 2010-06-15 Abbott Diabetes Care Inc. On-body medical device securement
EP1815790A1 (en) * 2006-02-04 2007-08-08 Roche Diagnostics GmbH Lancet device with impedance measuring unit
US11318249B2 (en) 2006-02-09 2022-05-03 Deka Products Limited Partnership Infusion pump assembly
WO2007092637A2 (en) 2006-02-09 2007-08-16 Deka Products Limited Partnership Patch-sized fluid delivery systems and methods
JPWO2007091608A1 (en) 2006-02-10 2009-07-02 久光製薬株式会社 Transdermal drug administration device with microneedle
US20070202186A1 (en) 2006-02-22 2007-08-30 Iscience Interventional Corporation Apparatus and formulations for suprachoroidal drug delivery
US7981034B2 (en) 2006-02-28 2011-07-19 Abbott Diabetes Care Inc. Smart messages and alerts for an infusion delivery and management system
MX2008011714A (en) 2006-03-14 2008-11-12 Univ Southern California Mems device for delivery of therapeutic agents.
US9119945B2 (en) * 2006-04-20 2015-09-01 3M Innovative Properties Company Device for applying a microneedle array
WO2007131050A2 (en) * 2006-05-02 2007-11-15 Georgia Tech Research Corporation Method for drug delivery to ocular tissue using microneedle
US8197435B2 (en) 2006-05-02 2012-06-12 Emory University Methods and devices for drug delivery to ocular tissue using microneedle
US7621895B2 (en) * 2006-05-17 2009-11-24 Abbott Cardiovascular Systems Inc. Needle array devices and methods
US20070276318A1 (en) * 2006-05-26 2007-11-29 Mit, Llp Iontosonic-microneedle applicator apparatus and methods
US20090171269A1 (en) * 2006-06-29 2009-07-02 Abbott Diabetes Care, Inc. Infusion Device and Methods Therefor
US9119582B2 (en) 2006-06-30 2015-09-01 Abbott Diabetes Care, Inc. Integrated analyte sensor and infusion device and methods therefor
JP2009545368A (en) * 2006-08-01 2009-12-24 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ Ultrasonic enhanced micro needle
US8206296B2 (en) 2006-08-07 2012-06-26 Abbott Diabetes Care Inc. Method and system for providing integrated analyte monitoring and infusion system therapy management
US8932216B2 (en) 2006-08-07 2015-01-13 Abbott Diabetes Care Inc. Method and system for providing data management in integrated analyte monitoring and infusion system
JP2010502267A (en) * 2006-08-28 2010-01-28 エージェンシー・フォー・サイエンス・テクノロジー・アンド・リサーチ Microneedle and method for producing microneedle
WO2008027218A2 (en) * 2006-08-29 2008-03-06 Alza Corporation Drug electrotransport with hydration measurement of hydratable reservoir
WO2008036043A1 (en) * 2006-09-18 2008-03-27 Agency For Science, Technology And Research Needle structures and methods for fabricating needle structures
WO2008041183A2 (en) * 2006-10-05 2008-04-10 Technion Research & Development Foundation Ltd. Microtubes and methods of producing same
WO2008049609A1 (en) * 2006-10-25 2008-05-02 Roche Diagnostics Gmbh Uninterruptible power supply for a medical appliance
EP2076172A4 (en) * 2006-10-27 2012-03-21 Aretais Inc Use of coherent raman techniques for medical diagnostic and therapeutic purposes, and calibration techniques for same
US10525246B2 (en) * 2006-12-22 2020-01-07 Nanomed Skincare, Inc. Microdevice and method for transdermal delivery and sampling of active substances
US8845530B2 (en) * 2007-01-02 2014-09-30 Isense Corporation Resposable biosensor assembly and method of sensing
FR2912919B1 (en) 2007-02-22 2009-05-01 Bernard Perriere MINIATURIZED INJECTION DEVICE FOR MEDICAL USE
US20080249469A1 (en) * 2007-03-22 2008-10-09 Ponnambalam Selvaganapathy Method and apparatus for active control of drug delivery using electro-osmotic flow control
GB2448493B (en) * 2007-04-16 2009-10-14 Dewan Fazlul Hoque Chowdhury Microneedle transdermal delivery device
EP2146689B1 (en) 2007-04-16 2020-08-12 Corium, Inc. Solvent-cast microneedle arrays containing active
DE602008003791D1 (en) 2007-05-07 2011-01-13 Vascular Pathways Inc INTRODUCTION OF INTRAVENOUS CATHETER AND BLOOD DETECTING DEVICE AND METHOD OF USE
US20090069830A1 (en) * 2007-06-07 2009-03-12 Piezo Resonance Innovations, Inc. Eye surgical tool
PT2158908E (en) * 2007-06-21 2013-05-07 Fujimoto Co Ltd Composition for transdermal administration
US8641618B2 (en) 2007-06-27 2014-02-04 Abbott Diabetes Care Inc. Method and structure for securing a monitoring device element
US8085151B2 (en) 2007-06-28 2011-12-27 Abbott Diabetes Care Inc. Signal converting cradle for medical condition monitoring and management system
US8160900B2 (en) 2007-06-29 2012-04-17 Abbott Diabetes Care Inc. Analyte monitoring and management device and method to analyze the frequency of user interaction with the device
US8328738B2 (en) 2007-06-29 2012-12-11 Actuated Medical, Inc. Medical tool for reduced penetration force with feedback means
US9987468B2 (en) 2007-06-29 2018-06-05 Actuated Medical, Inc. Reduced force device for intravascular access and guidewire placement
US10219832B2 (en) 2007-06-29 2019-03-05 Actuated Medical, Inc. Device and method for less forceful tissue puncture
US8043229B2 (en) * 2007-06-29 2011-10-25 Actuated Medical, Inc. Medical tool for reduced penetration force
WO2009015389A2 (en) * 2007-07-26 2009-01-29 Entra Pharmaceuticals Inc. Skin-patch pump comprising a changing-volume electrochemical actuator
WO2009023798A2 (en) * 2007-08-14 2009-02-19 Fred Hutchinson Cancer Research Center Needle array assembly and method for delivering therapeutic agents
US8583225B2 (en) * 2007-08-24 2013-11-12 Agency For Science, Technology And Research System and method for detecting skin penetration
US11154698B2 (en) * 2007-08-24 2021-10-26 Deka Products Limited Partnership Microneedle systems and apparatus
US9096845B2 (en) * 2007-08-29 2015-08-04 Technion Research & Development Foundation Limited Encapsulation of bacteria and viruses in electrospun fibers
US20090088682A1 (en) * 2007-09-28 2009-04-02 Seattle Medical Technologies Wearable infusion device
US8439940B2 (en) 2010-12-22 2013-05-14 Cabochon Aesthetics, Inc. Dissection handpiece with aspiration means for reducing the appearance of cellulite
WO2010042045A1 (en) 2008-10-10 2010-04-15 Milux Holding S.A. A system, an apparatus, and a method for treating a sexual dysfunctional female patient
US9022973B2 (en) * 2007-12-17 2015-05-05 New World Pharmaceuticals, Llc Integrated intra-dermal delivery, diagnostic and communication system
EP2666510B1 (en) 2007-12-20 2017-10-18 University Of Southern California Apparatus for controlled delivery of therapeutic agents
FI20075978A0 (en) * 2007-12-31 2007-12-31 Katja Paassilta Arrangement and method
US8414563B2 (en) 2007-12-31 2013-04-09 Deka Products Limited Partnership Pump assembly with switch
CA3059311A1 (en) 2007-12-31 2009-07-16 Deka Products Limited Partnership Wearable infusion pump assembly
US11357910B2 (en) 2007-12-31 2022-06-14 Deka Products Limited Partnership Pump assembly with switch
US8986253B2 (en) 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
US8961448B2 (en) 2008-01-28 2015-02-24 Peter Forsell Implantable drainage device
EP2240138B1 (en) 2008-01-29 2021-07-21 Implantica Patent Ltd. Apparatus for treating obesity
US9464368B2 (en) * 2008-02-21 2016-10-11 Technion Research & Development Foundation Ltd. Methods of attaching a molecule-of-interest to a microtube
US20090221893A1 (en) * 2008-02-29 2009-09-03 Path Scientific, Llc Unitized Painfree Blood Glucose Measuring Device
JP2009222474A (en) * 2008-03-14 2009-10-01 Panasonic Corp Micro-liquid transfer apparatus and micro-mliquid transfer method
US9199035B2 (en) 2008-05-08 2015-12-01 Minipumps, Llc. Drug-delivery pumps with dynamic, adaptive control
WO2009137780A2 (en) 2008-05-08 2009-11-12 Replenish Pumps, Llc Implantable pumps and cannulas therefor
EP2323716B1 (en) 2008-05-08 2015-03-04 MiniPumps, LLC Drug-delivery pumps
US9333297B2 (en) 2008-05-08 2016-05-10 Minipumps, Llc Drug-delivery pump with intelligent control
AU2009249610B2 (en) 2008-05-21 2014-01-16 Theraject, Inc. Method of manufacturing solid solution perforator patches and uses thereof
US8591410B2 (en) 2008-05-30 2013-11-26 Abbott Diabetes Care Inc. Method and apparatus for providing glycemic control
US8924159B2 (en) 2008-05-30 2014-12-30 Abbott Diabetes Care Inc. Method and apparatus for providing glycemic control
AU2009269129B2 (en) 2008-06-30 2015-08-20 Afgin Pharma, Llc Topical regional neuro-affective therapy
JP4482617B2 (en) * 2008-07-08 2010-06-16 パナソニック株式会社 Fluid transfer device using conductive polymer
US8868176B2 (en) * 2008-07-22 2014-10-21 New York University Microelectrode-equipped subdural therapeutic agent delivery strip
WO2010023666A2 (en) * 2008-08-28 2010-03-04 Medingo Ltd. Device and method for enhanced subcutaneous insulin absorption
US8408421B2 (en) 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
EP2334234A4 (en) 2008-09-19 2013-03-20 Tandem Diabetes Care Inc Solute concentration measurement device and related methods
SI2349383T1 (en) 2008-10-10 2022-02-28 Medicaltree Patent Ltd. Heart help device and system
EP2349170B1 (en) 2008-10-10 2023-09-27 Implantica Patent Ltd. Apparatus for the treatment of female sexual dysfunction
US20110196484A1 (en) 2008-10-10 2011-08-11 Milux Holding Sa Heart help method
WO2010042032A1 (en) 2008-10-10 2010-04-15 Milux Holding S.A. Fastening means for implantable medcial control assembly
EP2349096B1 (en) 2008-10-10 2021-01-27 MedicalTree Patent Ltd. An improved artificial valve
US9168364B2 (en) 2008-11-04 2015-10-27 Janisys Limited Transfer device for transferring a substance between the device and a subject
US20110301628A1 (en) * 2008-12-05 2011-12-08 Yossi Gross Techniques for use with a nail penetration device
EP2370141A1 (en) 2008-12-19 2011-10-05 Janisys Limited A fluid transfer device and an active substance cartridge for the fluid transfer device, and a method for controlling the pressure at which an active substance is delivered to a subject from a fluid transfer device
US20100187132A1 (en) * 2008-12-29 2010-07-29 Don Alden Determination of the real electrochemical surface areas of screen printed electrodes
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
US9033898B2 (en) 2010-06-23 2015-05-19 Seventh Sense Biosystems, Inc. Sampling devices and methods involving relatively little pain
CN102405018B (en) * 2009-03-02 2014-11-19 第七感生物系统有限公司 Techniques and devices associated with blood sampling
WO2010107707A2 (en) 2009-03-17 2010-09-23 Savage Walter T External defibrillator
US8781576B2 (en) * 2009-03-17 2014-07-15 Cardiothrive, Inc. Device and method for reducing patient transthoracic impedance for the purpose of delivering a therapeutic current
DE102009002019A1 (en) 2009-03-31 2010-10-07 Robert Bosch Gmbh Applicator for the treatment of skin
US8483967B2 (en) 2009-04-29 2013-07-09 Abbott Diabetes Care Inc. Method and system for providing real time analyte sensor calibration with retrospective backfill
EP2424610A2 (en) * 2009-04-29 2012-03-07 Janisys Limited A micro-needle device and apparatus and a method for applying a micro-needle element to a site on the skin of a subject
EP2432525A1 (en) * 2009-05-20 2012-03-28 Sanofi-Aventis Deutschland GmbH Drug delivery device
US9949812B2 (en) 2009-07-17 2018-04-24 Peter Forsell Vaginal operation method for the treatment of anal incontinence in women
US10952836B2 (en) 2009-07-17 2021-03-23 Peter Forsell Vaginal operation method for the treatment of urinary incontinence in women
CA2921304C (en) 2009-07-30 2018-06-05 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
RU2508135C2 (en) 2009-07-31 2014-02-27 3М Инновейтив Пропертиз Компани Hollow microneedle matrix
US11096708B2 (en) 2009-08-07 2021-08-24 Ulthera, Inc. Devices and methods for performing subcutaneous surgery
US9358064B2 (en) 2009-08-07 2016-06-07 Ulthera, Inc. Handpiece and methods for performing subcutaneous surgery
US8758271B2 (en) 2009-09-01 2014-06-24 Massachusetts Institute Of Technology Nonlinear system identification techniques and devices for discovering dynamic and static tissue properties
US20110060202A1 (en) * 2009-09-08 2011-03-10 Seth Adrian Miller Dehydration detector using micro-needles
JP5701882B2 (en) * 2009-09-10 2015-04-15 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Drug container
US8834423B2 (en) 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
WO2011053796A2 (en) * 2009-10-30 2011-05-05 Seventh Sense Biosystems, Inc. Systems and methods for treating, sanitizing, and/or shielding the skin or devices applied to the skin
US8685038B2 (en) 2009-12-07 2014-04-01 Incube Labs, Llc Iontophoretic apparatus and method for marking of the skin
WO2011075535A1 (en) 2009-12-15 2011-06-23 Massachusetts Institute Of Technology Plaque removal and differentiation of tooth and gum
US20110172637A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Drug delivery device including tissue support structure
EP2523603A2 (en) * 2010-01-13 2012-11-21 Seventh Sense Biosystems, Inc. Sampling device interfaces
CN102811754B (en) * 2010-01-13 2017-05-17 第七感生物系统有限公司 Rapid delivery and/or withdrawal of fluids
EP3243435A1 (en) * 2010-01-13 2017-11-15 Seventh Sense Biosystems, Inc. Sampling device interfaces
WO2011094573A1 (en) 2010-01-28 2011-08-04 Seventh Sense Biosystems, Inc. Monitoring or feedback systems and methods
US8366667B2 (en) * 2010-02-11 2013-02-05 Baxter International Inc. Flow pulsatility dampening devices
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US8920376B2 (en) 2010-04-20 2014-12-30 Minipumps, Llc Fill-status sensors for drug pump devices
MX336139B (en) 2010-04-28 2016-01-08 Kimberly Clark Co MEDICAL DEVICES FOR DELIVERY OF siRNA.
MX345837B (en) 2010-04-28 2017-02-16 Kimberly-Clark Worldwide Incorporated Device for delivery of rheumatoid arthritis medication.
US9629979B2 (en) * 2010-04-28 2017-04-25 Sanovas, Inc. Pressure/Vacuum actuated catheter drug delivery probe
CA2796965C (en) 2010-04-28 2019-04-16 Kimberly-Clark Worldwide, Inc. Method for increasing permeability of an epithelial barrier
AU2011246882B2 (en) 2010-04-28 2016-02-25 Sorrento Therapeutics, Inc. Nanopatterned medical device with enhanced cellular interaction
JP6327852B2 (en) 2010-05-04 2018-05-23 コリウム インターナショナル， インコーポレイテッド Methods and devices for transdermal delivery of parathyroid hormone using microprojection arrays
US8337457B2 (en) 2010-05-05 2012-12-25 Springleaf Therapeutics, Inc. Systems and methods for delivering a therapeutic agent
US9950139B2 (en) 2010-05-14 2018-04-24 C. R. Bard, Inc. Catheter placement device including guidewire and catheter control elements
US8932258B2 (en) 2010-05-14 2015-01-13 C. R. Bard, Inc. Catheter placement device and method
US11925779B2 (en) 2010-05-14 2024-03-12 C. R. Bard, Inc. Catheter insertion device including top-mounted advancement components
US9872971B2 (en) 2010-05-14 2018-01-23 C. R. Bard, Inc. Guidewire extension system for a catheter placement device
US10384039B2 (en) 2010-05-14 2019-08-20 C. R. Bard, Inc. Catheter insertion device including top-mounted advancement components
US9125625B2 (en) 2010-06-10 2015-09-08 The Regents Of The University Of California Textile-based printable electrodes for electrochemical sensing
US9227021B2 (en) 2010-06-29 2016-01-05 Genesis Biosystems, Inc. Microneedle roller (MNR) infusion system
EP2593014B1 (en) 2010-07-16 2015-11-04 Seventh Sense Biosystems, Inc. Low-pressure environment for fluid transfer devices
US20130158482A1 (en) 2010-07-26 2013-06-20 Seventh Sense Biosystems, Inc. Rapid delivery and/or receiving of fluids
US9017255B2 (en) 2010-07-27 2015-04-28 Carefusion 303, Inc. System and method for saving battery power in a patient monitoring system
US9055925B2 (en) 2010-07-27 2015-06-16 Carefusion 303, Inc. System and method for reducing false alarms associated with vital-signs monitoring
US9615792B2 (en) 2010-07-27 2017-04-11 Carefusion 303, Inc. System and method for conserving battery power in a patient monitoring system
US9357929B2 (en) 2010-07-27 2016-06-07 Carefusion 303, Inc. System and method for monitoring body temperature of a person
US9585620B2 (en) 2010-07-27 2017-03-07 Carefusion 303, Inc. Vital-signs patch having a flexible attachment to electrodes
US8814792B2 (en) 2010-07-27 2014-08-26 Carefusion 303, Inc. System and method for storing and forwarding data from a vital-signs monitor
US9420952B2 (en) 2010-07-27 2016-08-23 Carefusion 303, Inc. Temperature probe suitable for axillary reading
DE102010038733A1 (en) 2010-07-30 2012-02-02 Robert Bosch Gmbh Modular microneedle transport device
US20120039809A1 (en) 2010-08-13 2012-02-16 Seventh Sense Biosystems, Inc. Systems and techniques for monitoring subjects
US9173994B2 (en) * 2010-08-20 2015-11-03 Purdue Research Foundation Touch-actuated micropump for transdermal drug delivery and method of use
WO2012042517A1 (en) 2010-09-27 2012-04-05 Steadymed, Ltd. Size-efficient drug-delivery device
US8740838B2 (en) 2010-10-07 2014-06-03 Massachusetts Institute Of Technology Injection methods using a servo-controlled needle-free injector
US8821434B2 (en) 2010-10-07 2014-09-02 Massachusetts Institute Of Technology Delivery of a solid body and/or a fluid using a linear Lorentz-force actuated needle-free jet injection system
EP3520749A1 (en) 2010-10-15 2019-08-07 Clearside Biomedical, Inc. Device for ocular access
WO2012058192A1 (en) * 2010-10-26 2012-05-03 7944942 Canada Inc. Automatic medication injection device
US9017289B2 (en) 2010-11-03 2015-04-28 Covidien Lp Transdermal fluid delivery device
CN103370007B (en) 2010-11-09 2018-12-18 第七感生物系统有限公司 System and interface for blood sampling
EP2652324A2 (en) 2010-12-17 2013-10-23 Massachusetts Institute Of Technology Electrochemical actuators
US8690833B2 (en) 2011-01-31 2014-04-08 Vascular Pathways, Inc. Intravenous catheter and insertion device with reduced blood spatter
JP5982407B2 (en) * 2011-02-09 2016-08-31 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ Improvement of infusion system
EP3563898B1 (en) 2011-02-25 2020-11-11 C.R. Bard, Inc. Medical component insertion device including a retractable needle
US10136845B2 (en) 2011-02-28 2018-11-27 Abbott Diabetes Care Inc. Devices, systems, and methods associated with analyte monitoring devices and devices incorporating the same
US8696637B2 (en) 2011-02-28 2014-04-15 Kimberly-Clark Worldwide Transdermal patch containing microneedles
AU2012236099A1 (en) 2011-03-31 2013-10-03 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
WO2012139593A2 (en) * 2011-04-15 2012-10-18 Rigshospitalet Copenhagen University Hospital System and method for injecting a substance into a human body
RU2013151159A (en) * 2011-04-19 2015-05-27 ИНВИЗИДЕРМ, ЭлЭлСи METHOD FOR CREATING SUBSTANCES THAT OVERSATURATED WITH GAS, DEVICE FOR TRANSDERMAL DELIVERY AND ITS USE
BR112013027010A2 (en) * 2011-04-19 2016-12-27 Invisiderm Llc method of producing substances with supersaturated gas, device for their transdermal delivery, and their uses
EP2701598A1 (en) 2011-04-29 2014-03-05 Seventh Sense Biosystems, Inc. Systems and methods for collecting fluid from a subject
EP3235429B1 (en) 2011-04-29 2023-06-07 YourBio Health, Inc. Devices and methods for collection of blood from a subject
BR112013027351B1 (en) 2011-04-29 2022-03-03 Seventh Sense Biosystems, Inc Device for receiving fluid from an individual
US20130158468A1 (en) 2011-12-19 2013-06-20 Seventh Sense Biosystems, Inc. Delivering and/or receiving material with respect to a subject surface
USD903101S1 (en) 2011-05-13 2020-11-24 C. R. Bard, Inc. Catheter
US8636696B2 (en) 2011-06-10 2014-01-28 Kimberly-Clark Worldwide, Inc. Transdermal device containing microneedles
WO2013006643A1 (en) 2011-07-06 2013-01-10 The Parkinson's Institute Compositions and methods for treatment of symptoms in parkinson's disease patients
JP2014533523A (en) * 2011-09-02 2014-12-15 ザ レジェンツ オブ ザ ユニヴァーシティー オブ カリフォルニア Microneedle arrays for biosensing and drug delivery
EP3574950B1 (en) 2011-10-27 2021-02-17 Sorrento Therapeutics, Inc. Transdermal delivery of high viscosity bioactive agents
US20170246439A9 (en) 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
HUE058275T2 (en) 2011-10-27 2022-07-28 Sorrento Therapeutics Inc Implantable devices for delivery of bioactive agents
CN104023760A (en) 2011-10-28 2014-09-03 普莱萨格生命科学公司 Methods for drug delivery
US9317656B2 (en) 2011-11-23 2016-04-19 Abbott Diabetes Care Inc. Compatibility mechanisms for devices in a continuous analyte monitoring system and methods thereof
RS63244B1 (en) 2011-12-16 2022-06-30 Modernatx Inc Modified mrna compositions
DE102011089723A1 (en) * 2011-12-23 2013-06-27 Robert Bosch Gmbh Microneedle array applicator and method of applying a microneedle array
US10130800B2 (en) 2012-01-27 2018-11-20 Invisiderm, Llc Method of producing substances with supersaturated gas, transdermal delivery device thereof, and uses thereof
US10010676B2 (en) * 2012-03-13 2018-07-03 Becton Dickinson France Method of manufacture for a miniaturized drug delivery device
WO2013136327A1 (en) 2012-03-15 2013-09-19 Steadymed Ltd. Enhanced infusion-site pain-reduction for drug-delivery devices
WO2013140395A1 (en) 2012-03-19 2013-09-26 Steadymed Ltd. Fluid-connection mechanism for patch-pumps
KR20130114996A (en) * 2012-04-10 2013-10-21 삼성디스플레이 주식회사 Display apparatus and fabricating method thereof
CA2871770C (en) 2012-05-01 2020-07-07 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Tip-loaded microneedle arrays for transdermal insertion
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
US9555186B2 (en) 2012-06-05 2017-01-31 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
SG11201500075WA (en) * 2012-07-06 2015-02-27 Gen Hospital Corp Method and apparatus for dermatological treatment
WO2019135244A2 (en) * 2018-01-07 2019-07-11 Avraham Amir High-load microneedles and compositions for skin augmentation
US9782538B2 (en) 2012-09-27 2017-10-10 Becton, Dickinson And Company Angled inserter for drug infusion
CA2890471C (en) 2012-11-08 2021-07-27 Clearside Biomedical, Inc. Methods and devices for the treatment of ocular diseases in human subjects
ES2921623T3 (en) 2012-11-26 2022-08-30 Modernatx Inc terminally modified RNA
MX2015008157A (en) 2012-12-21 2016-02-22 Corium Int Inc Microarray for delivery of therapeutic agent and methods of use.
WO2014113089A2 (en) 2013-01-17 2014-07-24 Moderna Therapeutics, Inc. Signal-sensor polynucleotides for the alteration of cellular phenotypes
US10105487B2 (en) 2013-01-24 2018-10-23 Chrono Therapeutics Inc. Optimized bio-synchronous bioactive agent delivery system
US9522254B2 (en) 2013-01-30 2016-12-20 Vascular Pathways, Inc. Systems and methods for venipuncture and catheter placement
EP2961471B1 (en) * 2013-02-28 2023-10-25 Sorrento Therapeutics, Inc. Transdermal drug delivery device
ES2921481T3 (en) 2013-03-12 2022-08-26 Corium Inc Microprojection applicators
WO2014159813A1 (en) 2013-03-13 2014-10-02 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
JP6098250B2 (en) * 2013-03-14 2017-03-22 セイコーエプソン株式会社 Liquid transport device
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
US10080839B2 (en) 2013-03-14 2018-09-25 Becton, Dickinson And Company Angled inserter for drug infusion
US9603995B2 (en) 2013-03-15 2017-03-28 Tandem Diabetes Care. Inc. Device and method for setting therapeutic parameters for an infusion device
CA2903763C (en) 2013-03-15 2021-11-16 Corium International, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
EP2968118B1 (en) 2013-03-15 2022-02-09 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
US10646664B2 (en) * 2013-03-15 2020-05-12 Amgen Inc. Body contour adaptable autoinjector device
EP2968751B1 (en) * 2013-03-15 2022-11-30 Corium, Inc. Multiple impact microprojection applicators
US9821113B2 (en) 2013-03-15 2017-11-21 Becton, Dickinson And Company Automatic angled infusion set assembly
SG10201702674PA (en) 2013-05-03 2017-06-29 Clearside Biomedical Inc Apparatus and methods for ocular injection
US20140350518A1 (en) 2013-05-23 2014-11-27 Allergan, Inc. Syringe extrusion accessory
US20140350516A1 (en) 2013-05-23 2014-11-27 Allergan, Inc. Mechanical syringe accessory
EP3003454B1 (en) 2013-06-03 2020-01-08 Clearside Biomedical, Inc. Apparatus for drug delivery using multiple reservoirs
US10149973B2 (en) 2013-06-14 2018-12-11 Cardiothrive, Inc. Multipart non-uniform patient contact interface and method of use
US9616243B2 (en) 2013-06-14 2017-04-11 Cardiothrive, Inc. Dynamically adjustable multiphasic defibrillator pulse system and method
US10279189B2 (en) 2013-06-14 2019-05-07 Cardiothrive, Inc. Wearable multiphasic cardioverter defibrillator system and method
US9907970B2 (en) 2013-06-14 2018-03-06 Cardiothrive, Inc. Therapeutic system and method using biphasic or multiphasic pulse waveform
US9656094B2 (en) 2013-06-14 2017-05-23 Cardiothrive, Inc. Biphasic or multiphasic pulse generator and method
US9833630B2 (en) 2013-06-14 2017-12-05 Cardiothrive, Inc. Biphasic or multiphasic pulse waveform and method
US9849272B2 (en) * 2013-06-18 2017-12-26 Hisamitsu Pharmaceutical Co., Inc. Applicator
WO2014203910A1 (en) 2013-06-19 2014-12-24 久光製薬株式会社 Applicator
US20150027241A1 (en) * 2013-07-23 2015-01-29 Diba Industries, Inc. Piercing probes with offset conical piercing tip and fluid-sampling systems comprising the piercing probes
US10299793B2 (en) 2013-10-23 2019-05-28 Valtech Cardio, Ltd. Anchor magazine
EP3082760A1 (en) 2013-12-19 2016-10-26 Novartis AG LEPTIN mRNA COMPOSITIONS AND FORMULATIONS
WO2015119906A1 (en) 2014-02-05 2015-08-13 Amgen Inc. Drug delivery system with electromagnetic field generator
GB201403773D0 (en) * 2014-03-04 2014-04-16 Univ Cardiff Microneedle based cell delivery
US10279106B1 (en) 2014-05-08 2019-05-07 Tandem Diabetes Care, Inc. Insulin patch pump
US10029048B2 (en) 2014-05-13 2018-07-24 Allergan, Inc. High force injection devices
JP6817074B2 (en) 2014-06-03 2021-01-20 アムジエン・インコーポレーテツド Controllable drug delivery system and usage
CA2952958A1 (en) 2014-06-20 2015-12-23 Clearside Biomedical, Inc. Variable diameter cannula and methods for controlling insertion depth for medicament delivery
US10321858B2 (en) 2014-08-18 2019-06-18 Proteadx, Inc. Apparatus and methods for transdermal sensing of analytes in interstitial fluid and associated data transmission systems
EP3188714A1 (en) 2014-09-04 2017-07-12 Corium International, Inc. Microstructure array, methods of making, and methods of use
WO2016037127A1 (en) 2014-09-05 2016-03-10 C.R. Bard, Inc. Catheter insertion device including retractable needle
EP3193973A1 (en) * 2014-09-15 2017-07-26 Sanofi Medicament delivery device with rotatable housing on a base
DE102014219719B4 (en) * 2014-09-29 2018-05-03 Ipr Intelligente Peripherien Für Roboter Gmbh needle grippers
US10226585B2 (en) 2014-10-01 2019-03-12 Allergan, Inc. Devices for injection and dosing
USD750223S1 (en) 2014-10-14 2016-02-23 Clearside Biomedical, Inc. Medical injector for ocular injection
CN105873514B (en) * 2014-10-27 2018-10-26 深圳市光聚通讯技术开发有限公司 Dynamic glucose harvester and host
US11357916B2 (en) 2014-12-19 2022-06-14 Amgen Inc. Drug delivery device with live button or user interface field
EP3233163B1 (en) 2014-12-19 2021-10-13 Amgen Inc. Drug delivery device with proximity sensor
WO2016105478A1 (en) 2014-12-23 2016-06-30 Axell Wireless Ltd. Harmonizing noise aggregation and noise management in distributed antenna system
EP3045185A1 (en) * 2015-01-16 2016-07-20 Sanofi-Aventis Deutschland GmbH Connector for a container filled with a liquid medicament
WO2016123406A1 (en) 2015-01-28 2016-08-04 Chrono Therapeutics Inc. Drug delivery methods and systems
CA3069716C (en) 2015-02-17 2021-11-09 Amgen Inc. Drug delivery device with vacuum assisted securement and/or feedback
CN107530490B (en) 2015-03-10 2021-06-25 爱力根销售有限责任公司 Multi-needle syringe
CA2977814A1 (en) 2015-03-12 2016-09-15 Chrono Therapeutics Inc. Craving input and support system
US10441768B2 (en) 2015-03-18 2019-10-15 University of Pittsburgh—of the Commonwealth System of Higher Education Bioactive components conjugated to substrates of microneedle arrays
USD903100S1 (en) 2015-05-01 2020-11-24 C. R. Bard, Inc. Catheter placement device
JP6784352B2 (en) * 2015-05-11 2020-11-11 国立大学法人 東京医科歯科大学 Insulin delivery device
SG10202006540RA (en) 2015-05-15 2020-08-28 Bard Inc C R Catheter placement device including an extensible needle safety component
US10463847B2 (en) 2015-06-11 2019-11-05 Steadymed Ltd. Infusion set
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
US10940292B2 (en) 2015-07-08 2021-03-09 Actuated Medical, Inc. Reduced force device for intravascular access and guidewire placement
US11793543B2 (en) 2015-09-18 2023-10-24 Obvius Robotics, Inc. Device and method for automated insertion of penetrating member
US11684763B2 (en) 2015-10-16 2023-06-27 University of Pittsburgh—of the Commonwealth System of Higher Education Multi-component bio-active drug delivery and controlled release to the skin by microneedle array devices
US11744889B2 (en) 2016-01-05 2023-09-05 University of Pittsburgh—of the Commonwealth System of Higher Education Skin microenvironment targeted delivery for promoting immune and other responses
WO2017139375A1 (en) 2016-02-10 2017-08-17 Clearside Biomedical, Inc. Ocular injection kit, packaging, and methods of use
CN108778248A (en) * 2016-02-19 2018-11-09 北卡罗来纳州立大学 Method and composition related with physiological responses micropin delivery system
JP6910075B2 (en) 2016-03-28 2021-07-28 イコル メディカル システムズ，インク． Methods and devices for delivery of therapeutic agents
KR102288170B1 (en) 2016-04-08 2021-08-09 알레간 인코포레이티드 Aspiration and injection device
JP2019514581A (en) 2016-05-02 2019-06-06 クリアサイド バイオメディカル，インコーポレイテッド Systems and methods for ocular drug delivery
NL2016807B1 (en) * 2016-05-20 2017-11-27 Uprax System and method for applying microneedles
US20200306518A1 (en) * 2016-05-20 2020-10-01 Uprax Microsolutions B.V. System and method for applying microneedles
US10220195B2 (en) * 2016-06-08 2019-03-05 Eclipse Medcorp, Llc Radio frequency needling device for use with disposable needle cartridges
CN110177527B (en) 2016-08-12 2022-02-01 科尼尔赛德生物医学公司 Device and method for adjusting insertion depth of needle for medicament delivery
WO2018049413A1 (en) 2016-09-12 2018-03-15 C.R. Bard, Inc. Blood control for a catheter insertion device
US11241563B2 (en) 2016-12-22 2022-02-08 Johnson & Johnson Consumer Inc. Microneedle arrays and methods for making and using
EP3338832A1 (en) * 2016-12-23 2018-06-27 Sanofi-Aventis Deutschland GmbH Medicament delivery device
EP3565617A1 (en) 2017-01-06 2019-11-13 Chrono Therapeutics Inc. Transdermal drug delivery devices and methods
CA3054969A1 (en) 2017-03-01 2018-09-07 C.R. Bard, Inc. Catheter insertion device
USD867582S1 (en) 2017-03-24 2019-11-19 Allergan, Inc. Syringe device
CN109833562B (en) * 2017-11-27 2024-03-15 苏州纳通生物纳米技术有限公司 Disposable self-destruction type vibrating head assembly and permeation promoting instrument using same
US10828500B2 (en) 2017-12-22 2020-11-10 Cardiothrive, Inc. External defibrillator
CN111801133B (en) 2018-03-07 2022-12-06 巴德阿克塞斯系统股份有限公司 Guidewire advancement and blood flashback system for medical device insertion systems
US11090506B2 (en) * 2018-05-15 2021-08-17 Omm Imports, Inc. Disposable product cap and assembly having a manually usable thermo-optical device for skin care
CA3101966A1 (en) 2018-05-29 2019-12-05 Morningside Venture Investments Limited Drug delivery methods and systems
CA3101595A1 (en) * 2018-06-29 2020-01-02 Johnson & Johnson Consumer Inc. Three-dimensional microfluidics devices for the delivery of actives
USD921884S1 (en) 2018-07-27 2021-06-08 Bard Access Systems, Inc. Catheter insertion device
FR3084578B1 (en) * 2018-08-03 2024-01-12 Pkvitality MANAGEMENT OF MICRONEEDLE INVESTMENT
CA3208266C (en) 2019-02-22 2024-04-16 Deka Products Limited Partnership Infusion set and inserter assembly systems and methods
WO2020188484A1 (en) * 2019-03-19 2020-09-24 King Abdullah University Of Science And Technology Miniaturized delivery system and method
US11590332B2 (en) * 2019-04-17 2023-02-28 Path Scientific, Llc Precision microneedling device and methods of use
GB201908043D0 (en) * 2019-06-05 2019-07-17 Lekkos Vasileios Transdermal patch for therapeutic uses
KR102279603B1 (en) * 2019-06-11 2021-07-20 (주)비올 Needle assembly, skin stimulator including the same, and manufacturing method thereof
EP3997452A4 (en) * 2019-07-12 2023-08-16 Qulab Medical Ltd. Electrochemical fet sensor
WO2021020730A2 (en) * 2019-07-26 2021-02-04 주식회사 림사이언스 Apparatus for applying pressure to medical needle
CN112386778A (en) 2019-08-19 2021-02-23 贝克顿·迪金森公司 Midline catheter placement device
EP4051337A4 (en) * 2019-10-30 2023-11-01 Thermalin Inc. Agent delivery systems, devices, and methods
US20230191099A1 (en) * 2020-02-20 2023-06-22 Jubilee Biotech Co., Ltd. Applicator for drug delivery and microneedle patch used therefor
WO2022026764A1 (en) 2020-07-29 2022-02-03 Biolinq Inc. Continuous analyte monitoring system with microneedle array
CN112370653B (en) * 2020-11-12 2022-08-30 深圳市圣通生物科技有限公司 Spray disinfection type nanometer microneedle mesoderm leading-in beauty instrument
US20220273352A1 (en) * 2021-03-01 2022-09-01 Bluexthermal, Inc. Device and method for thermal modulation of tissue
US11452474B1 (en) 2021-04-14 2022-09-27 Satio, Inc. Dual lever dermal patch system
EP4153276A4 (en) 2021-05-08 2023-11-08 Biolinq, Inc. Fault detection for microneedle array based continuous analyte monitoring device
US11964121B2 (en) 2021-10-13 2024-04-23 Satio, Inc. Mono dose dermal patch for pharmaceutical delivery
US11877848B2 (en) 2021-11-08 2024-01-23 Satio, Inc. Dermal patch for collecting a physiological sample
US11510602B1 (en) 2021-11-08 2022-11-29 Satio, Inc. Dermal patch for collecting a physiological sample
EP4295873A1 (en) * 2022-06-21 2023-12-27 National University of Ireland Galway An infusion catheter system

Family Cites Families (144)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US447225A (en) * 1891-02-24 Machine for attaching stays to the corners of boxes
US3537A (en) 1844-04-13 X g gupping instrument
US3659A (en) * 1844-07-11 Machine for hulling and pearling rice
US1934043A (en) * 1929-05-17 1933-11-07 Standard Oil Dev Co Process of improvement of lubricating oils
DE596981C (en) 1931-10-30 1934-05-12 Mario Demarchi Dr Injection syringe
FR757501A (en) 1932-09-23 1933-12-28 Automatic device for handling injection syringes
US2088780A (en) 1936-10-09 1937-08-03 Sigurd E Follese Massage device
US2763935A (en) 1954-06-11 1956-09-25 Purdne Res Foundation Determining depth of layers of fat and of muscle on an animal body
US2945496A (en) 1958-08-18 1960-07-19 Fosdal Alfred Dental instrument for immobilizing tissue
DE1115722B (en) 1960-04-30 1961-10-26 Hoechst Ag Metal anode for the electrolytic separation of chlorine
GB1128329A (en) 1964-12-23 1968-09-25 Nat Res Dev Electrodes for making electrical contact to the living body of a mammal
US3568735A (en) * 1968-06-26 1971-03-09 Cooke Eng Co Laboratory microtitration dispensing apparatus
US3568732A (en) 1969-02-28 1971-03-09 Kelly James A Jun Splice straightener for aerial conductors
US3659600A (en) 1970-02-24 1972-05-02 Estin Hans H Magnetically operated capsule for administering drugs
US3727614A (en) 1971-05-13 1973-04-17 Merck & Co Inc Multiple dosage inoculator
US3964482A (en) 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US3738493A (en) 1971-09-24 1973-06-12 Analytical Instr Spec Apparatus for simultaneous application of samples to thin layer chromatography plates
BE795384A (en) 1972-02-14 1973-08-13 Ici Ltd DRESSINGS
CH557178A (en) 1972-08-10 1974-12-31 Siemens Ag DEVICE FOR DISPENSING DRUGS.
US3923060A (en) 1974-04-23 1975-12-02 Jr Everett H Ellinwood Apparatus and method for implanted self-powered medication dispensing having timing and evaluator means
US4140109A (en) 1977-10-17 1979-02-20 Savic Michael I Impedance-based method and apparatus for monitoring cryodestruction in controlled cryosurgery
FR2460343A1 (en) 1979-06-29 1981-01-23 Solvay CATHODE FOR THE ELECTROLYTIC PRODUCTION OF HYDROGEN
JPS5683360A (en) * 1979-12-10 1981-07-07 Olympus Optical Co Pneumoperitoneum needle
US4447225A (en) 1982-03-22 1984-05-08 Taff Barry E Multidose jet injector
US4619652A (en) 1982-12-23 1986-10-28 Alza Corporation Dosage form for use in a body mounted pump
US4505710A (en) 1983-05-13 1985-03-19 Collins Earl R Implantable fluid dispensing system
DE3502913C1 (en) 1985-01-29 1986-07-03 Günter Prof. Dr.rer.nat. 5100 Aachen Rau Sensor for non-invasive detection of electrophysiological values
US4777599A (en) 1985-02-26 1988-10-11 Gillette Company Viscoelastometry of skin using shear wave propagation
FR2594341B1 (en) * 1986-02-14 1990-08-10 Charton Jean Pierre INJECTOR APPARATUS FOR THE PRACTICE OF MESOTHERAPY
AT384737B (en) 1986-04-04 1987-12-28 Thoma Dipl Ing Dr Techn Herwig DEVICE FOR CONTINUOUSLY DELIVERING LIQUID MEDICINAL PRODUCTS
EP0260953B1 (en) * 1986-09-18 1994-03-30 Paul G. Yock Device for use in the cannulation of blood vessels
CA1283827C (en) 1986-12-18 1991-05-07 Giorgio Cirelli Appliance for injection of liquid formulations
US4808156A (en) 1987-03-09 1989-02-28 Dean Consuelo M Cannular instrument and method for inserting a cannular instrument into a vein
US6056716A (en) 1987-06-08 2000-05-02 D'antonio Consultants International Inc. Hypodermic fluid dispenser
DD262803A1 (en) 1987-08-05 1988-12-14 Transform Roentgen Matern Veb INJECTION DEVICE
US5312486A (en) 1987-12-24 1994-05-17 Frank Meyer Water-containing, hardenable foam compositions with inorganic components and process for their preparation
US4989614A (en) 1988-02-23 1991-02-05 Vance Products Incorporated Fine-needle aspiration cell sampling methods
CA2008262A1 (en) * 1989-01-30 1990-07-30 John A. Gilly Clinical applicator
US5062834A (en) 1989-02-24 1991-11-05 Product Development (S.G.Z.) Ltd Device for dispensing a liquid particularly useful for delivering medicaments at a predetermined rate
US5425706A (en) 1989-02-24 1995-06-20 S. I. Scientific Innovations Ltd. Dispensing device particularly useful for dispensing nutritional liquids
JPH0648975B2 (en) 1989-10-02 1994-06-29 俊郎 樋口 Micro injection device and injection control method thereof
US5262128A (en) 1989-10-23 1993-11-16 The United States Of America As Represented By The Department Of Health And Human Services Array-type multiple cell injector
EP0429842B1 (en) 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
US6090790A (en) 1989-12-14 2000-07-18 Eriksson; Elof Gene delivery by microneedle injection
US5697901A (en) 1989-12-14 1997-12-16 Elof Eriksson Gene delivery by microneedle injection
US5092901A (en) 1990-06-06 1992-03-03 The Royal Institution For The Advancement Of Learning (Mcgill University) Shape memory alloy fibers having rapid twitch response
US5156591A (en) 1990-12-13 1992-10-20 S. I. Scientific Innovations Ltd. Skin electrode construction and transdermal drug delivery device utilizing same
TW279133B (en) 1990-12-13 1996-06-21 Elan Med Tech
US5527288A (en) 1990-12-13 1996-06-18 Elan Medical Technologies Limited Intradermal drug delivery device and method for intradermal delivery of drugs
US5279544A (en) 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
US5279547A (en) 1991-01-03 1994-01-18 Alcon Surgical Inc. Computer controlled smart phacoemulsification method and apparatus
SE9101022D0 (en) * 1991-01-09 1991-04-08 Paal Svedman MEDICAL SUSPENSION DEVICE
US5312456A (en) 1991-01-31 1994-05-17 Carnegie Mellon University Micromechanical barb and method for making the same
JP3456994B2 (en) 1991-11-13 2003-10-14 エラン コーポレーション ピーエルシー Drug administration device
US6048337A (en) 1992-01-07 2000-04-11 Principal Ab Transdermal perfusion of fluids
JP2547520B2 (en) 1992-01-21 1996-10-23 ヴァリーラブ・インコーポレーテッド Electrosurgical controller for trocar
US5252023A (en) * 1992-02-10 1993-10-12 Kelly Kevin M Lifting apparatus
JP2572823Y2 (en) 1992-02-13 1998-05-25 株式会社アドバンス Simple blood sampler
WO1993020784A1 (en) 1992-04-10 1993-10-28 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University A microneedle for injection of ocular blood vessels
US5478328A (en) 1992-05-22 1995-12-26 Silverman; David G. Methods of minimizing disease transmission by used hypodermic needles, and hypodermic needles adapted for carrying out the method
JPH0698920A (en) * 1992-09-21 1994-04-12 Hayashi Shigetada Acupuncture precise measuring instrument
US5354273A (en) 1992-12-14 1994-10-11 Mallinckrodt Medical, Inc. Delivery apparatus with pressure controlled delivery
US5478323A (en) * 1993-04-02 1995-12-26 Eli Lilly And Company Manifold for injection apparatus
IE68890B1 (en) 1993-04-08 1996-07-24 Elan Med Tech Intradermal delivery device
US5335668A (en) * 1993-04-30 1994-08-09 Medical Scientific, Inc. Diagnostic impedance measuring system for an insufflation needle
JP3494183B2 (en) * 1993-08-10 2004-02-03 株式会社アドバンス Simple blood collection device
CA2171563A1 (en) 1993-09-14 1995-03-23 Eric Le Cheminant Injection device
US5389222A (en) 1993-09-21 1995-02-14 The United States Of America As Represented By The United States Department Of Energy Spring-loaded polymeric gel actuators
US5599345A (en) 1993-11-08 1997-02-04 Zomed International, Inc. RF treatment apparatus
US5997501A (en) 1993-11-18 1999-12-07 Elan Corporation, Plc Intradermal drug delivery device
CA2149943C (en) 1994-05-23 1999-07-13 Kwang Kyun Jang Skin perforating device for transdermal medication
CA2149836C (en) 1994-05-23 1999-07-06 Sang Bae Choi Perforating device for dermal administration
US5591139A (en) 1994-06-06 1997-01-07 The Regents Of The University Of California IC-processed microneedles
DE4420232A1 (en) 1994-06-07 1995-12-14 Robert Waltereit Penetration depth checking device for hollow needle or probe inserted in human or animal patient
US5649423A (en) 1994-06-07 1997-07-22 Sandia Corporation Micromechanism linear actuator with capillary force sealing
US5478315A (en) 1994-08-08 1995-12-26 Brothers Family Investments, L.C. Local anesthetic injection system
US5432098A (en) 1994-10-31 1995-07-11 Dynatech Precision Sampling Corporation Apparatus, and process, for automatically sampling solids and semi-solids materials for analysis
IE72524B1 (en) * 1994-11-04 1997-04-23 Elan Med Tech Analyte-controlled liquid delivery device and analyte monitor
GB9508606D0 (en) 1995-04-27 1995-06-14 Svedman Paul Suction blister sampling
WO1996037256A1 (en) 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical patch for enhancing the delivery of compounds through the skin
AU5740496A (en) 1995-05-22 1996-12-11 General Hospital Corporation, The Micromechanical device and method for enhancing delivery of compounds through the skin
US5827216A (en) * 1995-06-07 1998-10-27 Cormedics Corp. Method and apparatus for accessing the pericardial space
ZA9610374B (en) * 1995-12-11 1997-06-23 Elan Med Tech Cartridge-based drug delivery device
JPH09192218A (en) * 1996-01-16 1997-07-29 Hitachi Ltd Blood-sugar level control system
JPH09239031A (en) * 1996-03-09 1997-09-16 Honda Electron Co Ltd Injector mounting ultrasonic vibrator transducer
US5843016A (en) 1996-03-18 1998-12-01 Physion S.R.L. Electromotive drug administration for treatment of acute urinary outflow obstruction
US6117155A (en) 1996-05-01 2000-09-12 Lee; Young H. Coated needle for use with an intramuscular stimulation treatment device
US5785688A (en) 1996-05-07 1998-07-28 Ceramatec, Inc. Fluid delivery apparatus and method
US5954668A (en) 1996-06-14 1999-09-21 Medrad, Inc. Extravasation detector using microwave radiometry
CA2253549C (en) 1996-06-18 2005-10-25 Alza Corporation Device for enhancing transdermal agent delivery or sampling
US6183434B1 (en) 1996-07-03 2001-02-06 Spectrx, Inc. Multiple mechanical microporation of skin or mucosa
JPH1043296A (en) * 1996-08-05 1998-02-17 Terumo Corp Chemical injecting apparatus
EP0934093B1 (en) 1996-09-17 2003-01-15 Deka Products Limited Partnership System for delivery of drugs by transport
US6071251A (en) 1996-12-06 2000-06-06 Abbott Laboratories Method and apparatus for obtaining blood for diagnostic tests
SE9604564D0 (en) 1996-12-12 1996-12-12 Paal Svedman Method and apparatus for conducting electrical currents
US6246904B1 (en) 1996-12-17 2001-06-12 Alza Corporation Electrotransport drug delivery reservoirs containing inert fillers
US5928194A (en) 1997-04-07 1999-07-27 Maget; Henri J. R. Self-contained liquid microdispenser
US5928207A (en) 1997-06-30 1999-07-27 The Regents Of The University Of California Microneedle with isotropically etched tip, and method of fabricating such a device
US5972013A (en) 1997-09-19 1999-10-26 Comedicus Incorporated Direct pericardial access device with deflecting mechanism and method
JPH11137684A (en) * 1997-11-12 1999-05-25 Hiroshi Oya Indolent and safe syringe
ES2218706T3 (en) * 1997-11-26 2004-11-16 E-Z-Em, Inc. EXTRAVASATION DETECTION TECHNIQUE.
US6918901B1 (en) * 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
WO1999029364A1 (en) 1997-12-11 1999-06-17 Alza Corporation Device for enhancing transdermal agent flux
DK1037686T3 (en) 1997-12-11 2006-01-02 Alza Corp Apparatus for enhancing transdermal flow of agents
US6126629A (en) 1997-12-18 2000-10-03 Bausch & Lomb Surgical, Inc. Multiple port phaco needle
US6154673A (en) * 1997-12-30 2000-11-28 Agilent Technologies, Inc. Multilingual defibrillator
US6048204A (en) * 1998-02-03 2000-04-11 Lifecore Biomedical, Inc. Self tapping screw type dental implant
US5957895A (en) 1998-02-20 1999-09-28 Becton Dickinson And Company Low-profile automatic injection device with self-emptying reservoir
US6391005B1 (en) * 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US5971998A (en) 1998-03-31 1999-10-26 Donald G. Russell Support device and method for controlling breast thickness during stereotactic guided needle biopsy
CA2332112C (en) 1998-05-13 2004-02-10 Cygnus, Inc. Monitoring of physiological analytes
PT1077636E (en) 1998-05-13 2004-06-30 Cygnus Therapeutic Systems SIGNAL PROCESSING FOR PHYSIOLOGICAL ANALYZES MEDICATION
WO1999062576A1 (en) 1998-06-04 1999-12-09 Elan Corporation, Plc Gas driven drug delivery device
CA2330207C (en) 1998-06-10 2005-08-30 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
US6678556B1 (en) 1998-07-13 2004-01-13 Genetronics, Inc. Electrical field therapy with reduced histopathological change in muscle
GB9815819D0 (en) 1998-07-22 1998-09-16 Secr Defence Transferring materials into cells and a microneedle array
GB9815820D0 (en) 1998-07-22 1998-09-16 Secr Defence Improvements relating to micro-machining
EP1100566A4 (en) 1998-07-27 2002-03-20 Medi Ject Corp Loading mechanism for medical injector assembly
EP1113832A4 (en) 1998-09-18 2002-04-17 Univ Utah Res Found Surface micromachined microneedles
DE19843733A1 (en) 1998-09-24 2000-03-30 Voith Sulzer Papiertech Patent Wiper blade assembly coating paper or card bands with optionally-viscous liquid, employs system of leaf spring tensioning which forms ductor chamber and is readily replaced and adjusted
US6148232A (en) 1998-11-09 2000-11-14 Elecsys Ltd. Transdermal drug delivery and analyte extraction
US6317630B1 (en) 1999-01-29 2001-11-13 Yossi Gross Drug delivery device
US6132449A (en) 1999-03-08 2000-10-17 Agilent Technologies, Inc. Extraction and transportation of blood for analysis
US6319230B1 (en) 1999-05-07 2001-11-20 Scimed Life Systems, Inc. Lateral needle injection apparatus and method
ATE462468T1 (en) 1999-06-04 2010-04-15 Georgia Tech Res Inst DEVICES FOR ENLARGED MICRONEEDLES PENETRATION IN BIOLOGICAL SKIN LAYERS
US6743211B1 (en) * 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6379324B1 (en) 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
CA2371888A1 (en) * 1999-06-18 2000-12-28 University Of Virginia An apparatus for fluid transport and related method thereof
US6408204B1 (en) 1999-07-28 2002-06-18 Medrad, Inc. Apparatuses and methods for extravasation detection
ES2248165T3 (en) * 1999-11-15 2006-03-16 Velcro Industries B.V. SKIN FIXING ELEMENT.
JP2003516798A (en) * 1999-12-16 2003-05-20 アルザ・コーポレーション Device for increasing the transdermal flow rate of extracted drugs
US7003336B2 (en) * 2000-02-10 2006-02-21 Medtronic Minimed, Inc. Analyte sensor method of making the same
US6572740B2 (en) 2000-04-13 2003-06-03 Elan Pharma International Limited Electrolytic cell
US6565532B1 (en) 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
US6440096B1 (en) * 2000-07-14 2002-08-27 Becton, Dickinson And Co. Microdevice and method of manufacturing a microdevice
JP2002028247A (en) * 2000-07-18 2002-01-29 Japan Science & Technology Corp Method and instrument for sensing venous pricking by puncture needle
ES2574917T3 (en) 2000-11-30 2016-06-23 Valeritas, Inc. Fluid supply and measurement systems and procedures
WO2002100469A2 (en) 2001-06-11 2002-12-19 Glaxo Group Limited Medicament dispenser for containers of varying sizes
US6835193B2 (en) 2001-07-10 2004-12-28 Myocardial Therapeutics, Inc. Methods for controlled depth injections into interior body cavities
US7429258B2 (en) 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
US7364586B2 (en) * 2001-12-21 2008-04-29 The Trustees Of Columbia University In The City Of New York C3 exoenzyme-coated stents and uses thereof for treating and preventing restenosis
EP1403519A1 (en) * 2002-09-27 2004-03-31 Novo Nordisk A/S Membrane pump with stretchable pump membrane

Also Published As

Publication number Publication date
CA2464487A1 (en) 2003-05-08
EP1439871B1 (en) 2009-01-14
ATE419885T1 (en) 2009-01-15
US7651475B2 (en) 2010-01-26
CA2464483A1 (en) 2003-05-08
WO2003037406A2 (en) 2003-05-08
US20030083618A1 (en) 2003-05-01
EP1439871A1 (en) 2004-07-28
EP1443990A1 (en) 2004-08-11
JP2005507715A (en) 2005-03-24
CA2464485C (en) 2010-05-11
US20080319392A1 (en) 2008-12-25
US7645263B2 (en) 2010-01-12
US7066922B2 (en) 2006-06-27
ATE420680T1 (en) 2009-01-15
ATE386561T1 (en) 2008-03-15
US20030083645A1 (en) 2003-05-01
EP1448253B1 (en) 2009-01-07
EP1446176A1 (en) 2004-08-18
US20030083619A1 (en) 2003-05-01
EP1448253A1 (en) 2004-08-25
DE60225172D1 (en) 2008-04-03
WO2003037406A3 (en) 2004-01-29
JP2009219886A (en) 2009-10-01
EP1438092A2 (en) 2004-07-21
JP2005507713A (en) 2005-03-24
JP4612304B2 (en) 2011-01-12
AU2002348009B9 (en) 2006-08-10
EP1446176B1 (en) 2008-02-20
US20080281273A1 (en) 2008-11-13
CA2464673A1 (en) 2003-05-08
JP2005507714A (en) 2005-03-24
JP2009240790A (en) 2009-10-22
US8246582B2 (en) 2012-08-21
US20030083641A1 (en) 2003-05-01
DE60230896D1 (en) 2009-03-05
JP4610193B2 (en) 2011-01-12
WO2003037404A1 (en) 2003-05-08
JP2005507716A (en) 2005-03-24
DE60230795D1 (en) 2009-02-26
CA2464483C (en) 2013-04-02
AU2002348009B2 (en) 2006-06-29
CA2464485A1 (en) 2003-05-08
WO2003037405A8 (en) 2004-06-17
CA2464673C (en) 2011-04-26
US7364568B2 (en) 2008-04-29
JP2006081918A (en) 2006-03-30
AU2002353855B2 (en) 2006-12-14
JP2009219888A (en) 2009-10-01
US7429258B2 (en) 2008-09-30
US20030139727A1 (en) 2003-07-24
WO2003037403A1 (en) 2003-05-08
WO2003037405A9 (en) 2004-05-13
CA2464670C (en) 2011-04-26
WO2003037405A1 (en) 2003-05-08
WO2003037407A1 (en) 2003-05-08
JP4610192B2 (en) 2011-01-12
AU2002353840B2 (en) 2006-08-17
JP2009219887A (en) 2009-10-01
JP2005525141A (en) 2005-08-25

Similar Documents

Publication Publication Date Title
CA2464670A1 (en) Transdermal transport device with suction
DE602004021561D1 (en) DEVICES FOR INTERSTITIENT INJECTION OF BIOLOGICAL ACTIVE SUBSTANCES IN TISSUE
AU2002213168A1 (en) Microstructures for delivering a composition cutaneously to skin
AU2001288774B2 (en) Methods for inhibiting decrease in transdermal drug flux by inhibition of pathway closure
AU2001275260A1 (en) Method and apparatus for enhancing penetration of a puncturing member into the intradermal space
CA2425315A1 (en) Apparatus and method for piercing skin with microprotrusions
AU2088301A (en) Device for enhancing transdermal flux of sampled agents
CA2456626A1 (en) Microstructures for delivering a composition cutaneously to skin using rotatable structures
AU2001273340A1 (en) Microdevice and method of manufacturing a microdevice
CA2185024A1 (en) Transdermal drug delivery by electroincorporation of microcarriers
IL141209A0 (en) Apparatus for delivering a substance having one or more needles driven at high velocity
WO2004093705A3 (en) Assembly for breast immobilization
ATE463207T1 (en) DEVICES FOR THE INTERSTITIAL INJECTION OF BIOLOGICAL AGENTS INTO TISSUE
WO1999034734A8 (en) Biopsy instrument
WO2006073869A3 (en) System and method for inserting a needle into a blood vessel
CA2381153A1 (en) System and method for delivering agents into targeted tissue of a living being
WO2003089043A3 (en) Handheld transdermal drug delivery and analyte extraction
DE69718912D1 (en) NEEDLE FOR SUBCUTANEOUS ADMINISTRATION OF LIQUIDS
WO1994003099A3 (en) Biopsy needle
AU2001288774A1 (en) Methods for inhibiting decrease in transdermal drug flux by inhibition of pathway closure
ES2143641T3 (en) SURFACE EXPRESSION OF AN ENZYME IN GENE THERAPY BASED ON DRUGS.
ATE283090T1 (en) DEVICE FOR REMOVAL OF TATTOOS WITHOUT SCARS
US20070208363A1 (en) Device and Method of Minimally Invasive Tattooing and Tattoo Removal
US9364650B2 (en) Method for removing pigments from a pigmented section of skin
JPH0612004U (en) Continuous insizing machine

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed