CA2462256A1 - Apparatus and method for the repair of articular cartilage defects - Google Patents

Apparatus and method for the repair of articular cartilage defects Download PDF

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Publication number
CA2462256A1
CA2462256A1 CA002462256A CA2462256A CA2462256A1 CA 2462256 A1 CA2462256 A1 CA 2462256A1 CA 002462256 A CA002462256 A CA 002462256A CA 2462256 A CA2462256 A CA 2462256A CA 2462256 A1 CA2462256 A1 CA 2462256A1
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Prior art keywords
leg
bone
accordance
extending
encapsulation device
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CA002462256A
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French (fr)
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CA2462256C (en
Inventor
Paul Re
Mark A. Johanson
Peter F. Marshall
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Enterprises Holdings Inc
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Individual
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  • Prostheses (AREA)
  • Surgical Instruments (AREA)
  • Application Of Or Painting With Fluid Materials (AREA)
  • Materials For Medical Uses (AREA)

Abstract

An encapsulation device (5) for repair of articular cartilage defects includes a body for disposition adjacent a bone in an area of the cartilage defect (55), and elongated leg structure (25) extending from the body and for disposition in the bone in the area of the cartilage defect. The leg structure is provided with a length which is a plurality of magnitudes greater than a thickness of the body, and is of a generally conical configuration.

Claims (20)

What Is Claimed Is:
1. An encapsulation device for the repair of articular cartilage defects, the device comprising:
a body for disposition adjacent a bone in an area of the cartilage defect; and elongated leg structure extending from said body for disposition in the bone in the area of the cartilage defect, said leg structure having a length which is a plurality of magnitudes greater than a thickness of said body, and being of a generally conical configuration.
2. The device in accordance with claim 1 wherein said body comprises a peripheral frame portion and a cover portion and said leg structure comprises a plurality of elongated leg members extending from a distal side of said frame portion.
3. The device in accordance with claim 1 wherein said leg structure is provided with protrusions thereon for gripping the bone.
9. The device in accordance with claim 2 wherein each of said leg members is provided with a central channel therein, each of the channels opening on a proximal side of said frame member.
5. The device in accordance with claim 1 wherein said body comprises a mesh portion.
6. The device in accordance with claim 1 wherein said body comprises a collagen scaffold.
7. The device in accordance with claim 1 wherein said body comprises a frame member and a sheet of periosteum fixed thereto.
8. The device in accordance with claim 7 and further comprising sutures affixing said sheet to said frame.
9. The device in accordance with claim 1 wherein said body comprises a peripheral frame bounding a cover portion.
10. The device in accordance with claim 1 wherein said leg structure comprises at least one leg, and further wherein said at least one leg is provided at a distal end thereof with an end portion enlarged beyond a periphery of the leg at a proximal end of the end portion and a generally pointed end portion at a distal end of the end portion.
11. The device in accordance with claim 1 wherein said body portion comprises a frame for supporting a selected further body member, and said leg structure comprises a plurality of leg members extending distally from said frame.
12. The device in accordance with claim 1 wherein said body comprises a shell member and reinforcing struts fixed to said shell member and extending radially from a center of said shell member, and said leg structure comprises a single leg extending distally from a center of said body.
13. The device in accordance with claim 12 wherein said leg is cannulated.
14. The device in accordance with claim 1 wherein said body comprises a peripheral frame and struts extending from the frame inwardly and joined at a center of said body, and said leg structure comprises a single leg extending distally from a distal surface of the center of said body.
15. The device in accordance with claim 19 wherein said leg is cannulated.
16. The encapsulation device in accordance with claim 1 wherein the device is of a selected one of (i) bioabsorbable material and (ii) bioremodelable material.
17. The encapsulation device in accordance with claim 1 wherein the device is impregnated with cell growth material.
18. A system for effecting articular cartilage defect repair, the system comprising:
an encapsulation device comprising a body for disposition adjacent a bone in an area of the cartilage defect, and elongated leg structure extending from a distal surface of said body for disposition in the bone in the area of the cartilage defect, each leg of said leg structure being provided with a central opening therein extending from a proximal surface of said body;
a pilot hole device comprising a head portion, at least one elongated foot extending distally from said head portion, and a handle portion extending proximally from said head portion, said pilot hole device elongated foot being adapted to form a hole in the bone to receive a leg member of said leg structure; and an insertion tool comprising a head portion, at least one elongated foot extending from a distal end of said head portion, each elongated foot of said insertion tool head portion being adapted to be received by the central opening of one of the encapsulation device legs, and the insertion tool head portion is adapted to engage a proximal surface of said encapsulation device;
wherein said encapsulation device is adapted to be mounted on said insertion tool, said pilot hole device is adapted to form at least one hole in the bone, and said insertion tool may be manipulated to drive said encapsulation device leg structure into at least one hole in the bone, to place the encapsulation device distal surface adjacent the bone and in an area of the cartilage defect.
19. A tool for in-bone placement of an encapsulation device for the repair of an articular cartilage defect, the encapsulation device comprising a body portion and a cannulated leg extending distally from a center of a distal surface of the body portion, the tool comprising:
a head portion having a distal surface configured generally complementary to a proximal surface of the encapsulation device;
a handle portion extending proximally from said head portion;
the head portion and handle portion forming a bore extending axially of the head portion and handle portion; and an insertion spike extending through the bore and adapted to extend through the encapsulation device leg, with a pointed distal end of the spike extending distally from a distal end of the encapsulation device leg;
wherein the insertion spike is adapted to form a hole in the bone and the tool in adapted to push the encapsulation device leg into the hole and the encapsulation device body into adjacency with the bone.
20. A method for effecting a repair to an articular cartilage defect, the method comprising the steps of:
providing an encapsulation device comprising a body for disposition adjacent a bone in an area of the cartilage defect, and an elongated leg structure extending from the body for disposition in the bone in the area of the cartilage defect, said elongated leg structure comprising at least one leg;
producing an elongated hole in the bone for each leg of the encapsulation device leg structure; and driving each leg of the leg structure of the encapsulation device into the hole provided therefor in the bone to bring a distal surface of the encapsulation device body into adjacency with the bone.
CA2462256A 2001-10-01 2002-10-01 Apparatus and method for the repair of articular cartilage defects Expired - Fee Related CA2462256C (en)

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Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040081704A1 (en) 1998-02-13 2004-04-29 Centerpulse Biologics Inc. Implantable putty material
EP1099443A1 (en) 1999-11-11 2001-05-16 Sulzer Orthopedics Ltd. Transplant/implant device and method for its production
DE60041670D1 (en) * 1999-12-03 2009-04-09 Univ Leeds Restoration of damaged tissue
US20020114795A1 (en) 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
US7862831B2 (en) * 2002-10-09 2011-01-04 Synthasome, Inc. Method and material for enhanced tissue-biomaterial integration
US8673333B2 (en) * 2002-09-25 2014-03-18 The Johns Hopkins University Cross-linked polymer matrices, and methods of making and using same
US20050069572A1 (en) * 2002-10-09 2005-03-31 Jennifer Elisseeff Multi-layered polymerizing hydrogels for tissue regeneration
US20060147332A1 (en) 2004-12-30 2006-07-06 Howmedica Osteonics Corp. Laser-produced porous structure
US7537664B2 (en) * 2002-11-08 2009-05-26 Howmedica Osteonics Corp. Laser-produced porous surface
US8173162B2 (en) * 2003-02-26 2012-05-08 Zimmer Orthobiologics, Inc. Preparation for repairing cartilage tissue, especially articular cartilage defects
US7666230B2 (en) * 2003-12-08 2010-02-23 Depuy Products, Inc. Implant device for cartilage regeneration in load bearing articulation regions
JP2008515434A (en) * 2004-10-08 2008-05-15 ジョージア テック リサーチ コーポレイション Microencapsulation of cells in hydrogels using electrostatic potential
WO2006060416A2 (en) * 2004-11-30 2006-06-08 Osteobiologics, Inc. Implants and delivery system for treating defects in articulating surfaces
WO2006089119A2 (en) * 2005-02-18 2006-08-24 Cartilix, Inc. Biological adhesive
DE102005010989A1 (en) * 2005-03-03 2006-09-14 Karl Storz Gmbh & Co. Kg Medical instrument for introducing microfractures into bone
WO2006108045A2 (en) 2005-04-05 2006-10-12 Ans Research Corporation Articles, devices, and methods for pelvic surgery
EP1764117A1 (en) 2005-09-20 2007-03-21 Zimmer GmbH Implant for the repair of a cartilage defect and method for manufacturing the implant
US8728387B2 (en) 2005-12-06 2014-05-20 Howmedica Osteonics Corp. Laser-produced porous surface
CA2572095C (en) * 2005-12-30 2009-12-08 Howmedica Osteonics Corp. Laser-produced implants
US20080015691A1 (en) * 2006-06-15 2008-01-17 Depuy Products, Inc. Orthopaedic implants having bioresorbable posts
US8147861B2 (en) * 2006-08-15 2012-04-03 Howmedica Osteonics Corp. Antimicrobial implant
GB0623065D0 (en) * 2006-11-18 2006-12-27 Smith & Nephew Annular ring
US7718616B2 (en) * 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
WO2009014718A1 (en) 2007-07-24 2009-01-29 Porex Corporation Porous laser sintered articles
US8500759B2 (en) 2007-09-26 2013-08-06 Ethicon, Inc. Hernia mesh support device
WO2009064509A1 (en) * 2007-11-16 2009-05-22 Smith & Nephew, Inc. Annular ring implant
US8246570B2 (en) * 2007-12-21 2012-08-21 Japan Medical Materials Corporation Device for cell transplantation
US10172626B2 (en) * 2008-04-15 2019-01-08 The Lonnie and Shannon Paulos Trust Tissue microfracture apparatus and methods of use
US20100145451A1 (en) * 2008-12-04 2010-06-10 Derek Dee Joint support and subchondral support system
US10610364B2 (en) 2008-12-04 2020-04-07 Subchondral Solutions, Inc. Method for ameliorating joint conditions and diseases and preventing bone hypertrophy
EP2221014B1 (en) 2009-02-23 2015-05-20 Inion Oy Implant, implantation tool and kit
US8241298B2 (en) * 2009-03-27 2012-08-14 Depuy Mitek, Inc. Methods and devices for delivering and affixing tissue scaffolds
US8308814B2 (en) 2009-03-27 2012-11-13 Depuy Mitek, Inc. Methods and devices for preparing and implanting tissue scaffolds
US20100256765A1 (en) * 2009-04-01 2010-10-07 Butler Michael S Spinal Implants and Deployment Instruments For Covering Traumatized Spinal Disc Areas
US8911474B2 (en) 2009-07-16 2014-12-16 Howmedica Osteonics Corp. Suture anchor implantation instrumentation system
US9232954B2 (en) 2009-08-20 2016-01-12 Howmedica Osteonics Corp. Flexible ACL instrumentation, kit and method
JP2013542837A (en) 2010-11-15 2013-11-28 ジンマー オーソバイオロジクス,インコーポレイティド Bone void filler
AU2011332225B2 (en) * 2010-11-23 2016-05-26 Cc Innovation Surgical implant
US20130190873A1 (en) * 2012-01-20 2013-07-25 Kevin A. Mansmann Rim anchoring systems for flexible surgical implants for replacing cartilage
US9795398B2 (en) 2011-04-13 2017-10-24 Howmedica Osteonics Corp. Flexible ACL instrumentation, kit and method
US9445803B2 (en) 2011-11-23 2016-09-20 Howmedica Osteonics Corp. Filamentary suture anchor
US20130158588A1 (en) * 2011-12-14 2013-06-20 Innospan Enterprises, Inc. Abdominoplasty Umbilicus Finder Device and Method
US9364896B2 (en) 2012-02-07 2016-06-14 Medical Modeling Inc. Fabrication of hybrid solid-porous medical implantable devices with electron beam melting technology
EP2987458B1 (en) 2012-03-09 2018-10-31 George J. Sikora Microfracture apparatuses
US9180010B2 (en) 2012-04-06 2015-11-10 Howmedica Osteonics Corp. Surface modified unit cell lattice structures for optimized secure freeform fabrication
US9135374B2 (en) 2012-04-06 2015-09-15 Howmedica Osteonics Corp. Surface modified unit cell lattice structures for optimized secure freeform fabrication
US20140039552A1 (en) 2012-08-03 2014-02-06 Howmedica Osteonics Corp. Soft tissue fixation devices and methods
US9186380B2 (en) 2012-11-15 2015-11-17 Allosource Minced cartilage systems and methods
US9078740B2 (en) 2013-01-21 2015-07-14 Howmedica Osteonics Corp. Instrumentation and method for positioning and securing a graft
CA2894750C (en) 2013-02-22 2021-12-14 Allosource Cartilage mosaic compositions and methods
US9402620B2 (en) 2013-03-04 2016-08-02 Howmedica Osteonics Corp. Knotless filamentary fixation devices, assemblies and systems and methods of assembly and use
US9788826B2 (en) 2013-03-11 2017-10-17 Howmedica Osteonics Corp. Filamentary fixation device and assembly and method of assembly, manufacture and use
US9463013B2 (en) 2013-03-13 2016-10-11 Stryker Corporation Adjustable continuous filament structure and method of manufacture and use
KR102312720B1 (en) 2013-03-15 2021-10-13 알로소스 Cell repopulated collagen matrix for soft tissue repair and regeneration
US9168140B2 (en) 2013-03-15 2015-10-27 Allosource Perforated osteochondral allograft compositions
WO2014176270A1 (en) 2013-04-22 2014-10-30 Pivot Medical, Inc. Method and apparatus for attaching tissue to bone
WO2015041888A1 (en) 2013-09-23 2015-03-26 Sikora George J Microfracture apparatuses
US9895519B2 (en) 2013-10-07 2018-02-20 Regentis Biomaterials Ltd. Treatment of cavities in a human body
US9872705B2 (en) 2013-10-07 2018-01-23 Regentis Biomaterials Ltd. Treatment of cavities in a human body
US10610211B2 (en) 2013-12-12 2020-04-07 Howmedica Osteonics Corp. Filament engagement system and methods of use
JP6307875B2 (en) * 2013-12-26 2018-04-11 大日本印刷株式会社 Cell sheet collection method and collection device
US10702395B2 (en) 2014-10-01 2020-07-07 Arthrosurface, Inc. Microfracture apparatuses and methods
US10034742B2 (en) 2014-10-23 2018-07-31 Medos International Sarl Biceps tenodesis implants and delivery tools
US10751161B2 (en) 2014-10-23 2020-08-25 Medos International Sárl Biceps tenodesis anchor implants
US10076374B2 (en) 2014-10-23 2018-09-18 Medos International Sárl Biceps tenodesis delivery tools
US10729419B2 (en) 2014-10-23 2020-08-04 Medos International Sarl Biceps tenodesis implants and delivery tools
US10856966B2 (en) 2014-10-23 2020-12-08 Medos International Sarl Biceps tenodesis implants and delivery tools
US9986992B2 (en) 2014-10-28 2018-06-05 Stryker Corporation Suture anchor and associated methods of use
US10568616B2 (en) 2014-12-17 2020-02-25 Howmedica Osteonics Corp. Instruments and methods of soft tissue fixation
USD851250S1 (en) * 2015-11-19 2019-06-11 Orthovestments, Llc Bone staple
US9649108B2 (en) 2015-02-24 2017-05-16 Orthovestments, Llc Orthopedic bone staple with polyaxial compression capability
US9693856B2 (en) 2015-04-22 2017-07-04 DePuy Synthes Products, LLC Biceps repair device
US11039927B2 (en) 2015-11-25 2021-06-22 Subchondral Solutions, Inc. Methods, systems and devices for repairing anatomical joint conditions
ES2842295T3 (en) * 2015-12-23 2021-07-13 Inovedis Gmbh Tendon fixation plate
US10231824B2 (en) 2016-04-08 2019-03-19 Medos International Sárl Tenodesis anchoring systems and tools
US10231823B2 (en) 2016-04-08 2019-03-19 Medos International Sarl Tenodesis implants and tools
KR20170116680A (en) * 2016-04-12 2017-10-20 가톨릭대학교 산학협력단 The fixing device for articular cartilage damage
US11298747B2 (en) 2017-05-18 2022-04-12 Howmedica Osteonics Corp. High fatigue strength porous structure
DE102017115404A1 (en) * 2017-07-10 2019-01-10 Karl Leibinger Medizintechnik Gmbh & Co. Kg Bone augmentation piece and bone augmentation piece kit with inserted (dental) implant
US10842603B1 (en) * 2017-10-16 2020-11-24 David Lee Street Sutureless ventral hernia meshing system and method of fixation
CN109966029A (en) * 2017-12-28 2019-07-05 财团法人工业技术研究院 Repair of cartilage carrier, the operational tool group arranged in pairs or groups and cartilage repair systems
US10786370B2 (en) 2017-12-28 2020-09-29 Industrial Technology Research Institute Cartilage repair implant, auxiliary surgical tool kit and cartilage repair system
USD902405S1 (en) 2018-02-22 2020-11-17 Stryker Corporation Self-punching bone anchor inserter

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4060089A (en) * 1975-09-03 1977-11-29 United States Surgical Corporation Surgical fastening method and device therefor
US4512038A (en) 1979-04-27 1985-04-23 University Of Medicine And Dentistry Of New Jersey Bio-absorbable composite tissue scaffold
US4548202A (en) * 1983-06-20 1985-10-22 Ethicon, Inc. Mesh tissue fasteners
US4932973A (en) 1983-09-30 1990-06-12 El Gendler Cartilage and bone induction by artificially perforated organic bone matrix
CH669724A5 (en) * 1986-04-15 1989-04-14 Sulzer Ag
US4884572A (en) * 1986-05-20 1989-12-05 Concept, Inc. Tack and applicator for treating torn bodily material in vivo
US5139499A (en) * 1989-02-06 1992-08-18 American Cyanamid Company Screw and driver
US5258016A (en) * 1990-07-13 1993-11-02 American Cyanamid Company Suture anchor and driver assembly
CA2090000A1 (en) * 1992-02-24 1993-08-25 H. Jonathan Tovey Articulating mesh deployment apparatus
US5766246A (en) 1992-05-20 1998-06-16 C. R. Bard, Inc. Implantable prosthesis and method and apparatus for loading and delivering an implantable prothesis
US5632745A (en) * 1995-02-07 1997-05-27 R&D Biologicals, Inc. Surgical implantation of cartilage repair unit
US5769899A (en) 1994-08-12 1998-06-23 Matrix Biotechnologies, Inc. Cartilage repair unit
US5634926A (en) * 1995-04-25 1997-06-03 Jobe; Richard P. Surgical bone fixation apparatus
US5989269A (en) 1996-08-30 1999-11-23 Vts Holdings L.L.C. Method, instruments and kit for autologous transplantation
DE69838856T2 (en) * 1997-02-11 2008-12-11 Warsaw Orthopedic, Inc., Warsaw Plate for the anterior cervical spine with fixation system for one screw
ATE249175T1 (en) * 1997-02-28 2003-09-15 Synthes Ag IMPLANT FOR OSTEOSYNTHESIS
CA2311803A1 (en) * 1997-10-24 1999-05-06 Robert S. Bray, Jr. Bone plate and bone screw guide mechanism
US6251143B1 (en) * 1999-06-04 2001-06-26 Depuy Orthopaedics, Inc. Cartilage repair unit
US6179840B1 (en) * 1999-07-23 2001-01-30 Ethicon, Inc. Graft fixation device and method
US6533454B1 (en) * 1999-09-30 2003-03-18 Bionx Implants Oy Surgical system for tissue fixation
US6371958B1 (en) * 2000-03-02 2002-04-16 Ethicon, Inc. Scaffold fixation device for use in articular cartilage repair

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US20040181232A1 (en) 2004-09-16
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WO2003028535A2 (en) 2003-04-10

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