CA2436136A1 - Multi-channel bio-separation cartridge - Google Patents
Multi-channel bio-separation cartridge Download PDFInfo
- Publication number
- CA2436136A1 CA2436136A1 CA002436136A CA2436136A CA2436136A1 CA 2436136 A1 CA2436136 A1 CA 2436136A1 CA 002436136 A CA002436136 A CA 002436136A CA 2436136 A CA2436136 A CA 2436136A CA 2436136 A1 CA2436136 A1 CA 2436136A1
- Authority
- CA
- Canada
- Prior art keywords
- separation
- bio
- cartridge
- reservoir
- channels
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000926 separation method Methods 0.000 title claims abstract 39
- 230000005855 radiation Effects 0.000 claims abstract 10
- 238000001514 detection method Methods 0.000 claims abstract 7
- 239000000835 fiber Substances 0.000 claims abstract 3
- 238000010926 purge Methods 0.000 claims abstract 3
- 239000012530 fluid Substances 0.000 claims 3
- 238000005251 capillar electrophoresis Methods 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 238000001962 electrophoresis Methods 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44756—Apparatus specially adapted therefor
- G01N27/44782—Apparatus specially adapted therefor of a plurality of samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
- G01N27/44721—Arrangements for investigating the separated zones, e.g. localising zones by optical means
Abstract
A bio-separation system using an efficient, compact, portable, interchangeable, reusable, recyclable, multi-channel cartridge, has integrated pre-aligned optics and an integrated reagent reservoir. The cartridge supports, for example, multiple capillaries for CE separation. An integrated reservoir containing a separation support medium (e.g., a gel buffer) is common to all capillaries. The chemistry of the medium and the characteristics of the capillaries (e.g., capillary size, coating and length) are defined for each cartridge. Different cartridges can be easily interchanged in the bio-separation system to suit the particular sample based separation. The reservoir is coupled to an air pressure pump that pressurizes the gel reservoir to purge and fill the capillaries with buffer as the separation support medium. In another aspect of the present invention, optics requiring fine alignment with respect to the detection zones (such as fiber optics for directing incident radiation and/or radiation emissions) are integrated into the cartridge.
Claims (15)
1. A multi-channel cartridge for bio-separation, comprising:
a body;
a plurality of separation channels for analytes defined in the body, each defining a detection zone;
a chamber in the body defining a reservoir in fluid communication common with the separation channels, said chamber containing a separation support medium which is sealed from leakage when the cartridge is handled in an orientation; and optics aligned with respect to the detection zone for at least one of incident radiation and radiation output.
a body;
a plurality of separation channels for analytes defined in the body, each defining a detection zone;
a chamber in the body defining a reservoir in fluid communication common with the separation channels, said chamber containing a separation support medium which is sealed from leakage when the cartridge is handled in an orientation; and optics aligned with respect to the detection zone for at least one of incident radiation and radiation output.
2. The multi-channel cartridge as in claim 1, characterized by at least one of the following: portable, recyclable, reusable and interchangeable with other cartridges having different one of separation support medium and separation channels.
3. The multi-channel cartridge as in claim 1, further comprising an electrode electrically coupled to the reservoir.
4. The multi-channel cartridge as in claim 3, further comprising a further electrode electrically coupled to each end of the separation channels that are away from the reservoir.
5. The multi-channel cartridge as in claim 1, wherein the optics comprises optic fibers having an end aligned by the body to the separation channels.
6. The multi-channel cartridge as in claim 5, wherein the optics further comprises optic fibers having another end positioned by the body for coupling to external radiation sources.
7. The multi-channel cartridge as in claim 1, wherein the separation channels comprise capillary columns supported by the body.
8. The multi-channel cartridge as in claim 1, wherein the separation support medium comprises a gel.
9. The multi-channel cartridge as in claim 8, wherein the gel is of a type suitable for capillary electrophoresis.
10. The multi-channel cartridge as in claim 1, further comprising an interface for introducing pressurized air into the reservoir to purge and fill the separation channels with the separation support medium.
11. A bio-separation system, comprising:
a base;
a multi-channel cartridge for bio-separation supported on the base, comprising:
a body;
a plurality of separation channels defined in the body, each defining a detection zone;
a chamber in the body defining a reservoir in fluid communication common with the separation channels, said chamber containing a separation support medium which is sealed from leal~age when the cartridge is handled in an orientation;
optics aligned with respect to the detection zone for at least one of incident radiation and radiation output;
positioning means supported on the base for positioning samples with respect to the separation channels and in fluid communication with the separation channels;
separation means for effecting bio-separation of the samples along the separation channels; and control means for controlling operations of the bio-separation instrument.
a base;
a multi-channel cartridge for bio-separation supported on the base, comprising:
a body;
a plurality of separation channels defined in the body, each defining a detection zone;
a chamber in the body defining a reservoir in fluid communication common with the separation channels, said chamber containing a separation support medium which is sealed from leal~age when the cartridge is handled in an orientation;
optics aligned with respect to the detection zone for at least one of incident radiation and radiation output;
positioning means supported on the base for positioning samples with respect to the separation channels and in fluid communication with the separation channels;
separation means for effecting bio-separation of the samples along the separation channels; and control means for controlling operations of the bio-separation instrument.
12. The bio-separation instrument as in claim 11, further comprising:
a radiation source directing radiation at the detection zone; and a detector detecting radiation from the detection zone.
a radiation source directing radiation at the detection zone; and a detector detecting radiation from the detection zone.
13. The bio-separation instrument as in claim 11, wherein the separation means comprises electrophoretic means for effecting electrophoresis separation of the samples in the separation channels.
14. The bio-separation instrument as in claim 11, further comprising pressure means for pressurizing the reservoir to purge and fill the separation channels.
15. The bio-separation instrument as in claim 11, wherein the separation channels comprise capillary columns supported by the body.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26460501P | 2001-01-26 | 2001-01-26 | |
| US60/264,605 | 2001-01-26 | ||
| PCT/US2002/002515 WO2002059589A2 (en) | 2001-01-26 | 2002-01-28 | Multi-channel bio-separation cartridge |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2436136A1 true CA2436136A1 (en) | 2002-08-01 |
| CA2436136C CA2436136C (en) | 2010-04-20 |
Family
ID=23006811
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2436136A Expired - Lifetime CA2436136C (en) | 2001-01-26 | 2002-01-28 | Multi-channel bio-separation cartridge |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7309409B2 (en) |
| EP (1) | EP1354192B1 (en) |
| JP (1) | JP2004532384A (en) |
| CN (1) | CN100533138C (en) |
| AT (1) | ATE522802T1 (en) |
| AU (1) | AU2002247040A1 (en) |
| CA (1) | CA2436136C (en) |
| CY (1) | CY1112666T1 (en) |
| DK (1) | DK1354192T3 (en) |
| ES (1) | ES2370633T3 (en) |
| PT (1) | PT1354192E (en) |
| TW (1) | TWI273238B (en) |
| WO (1) | WO2002059589A2 (en) |
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| WO2003062815A1 (en) * | 2002-01-18 | 2003-07-31 | Biocal Technology, Inc. | Multi-segment cartridge for bio-separation with multiplexed fluorescence detection |
-
2002
- 2002-01-28 US US10/059,993 patent/US7309409B2/en not_active Expired - Lifetime
- 2002-01-28 AT AT02714795T patent/ATE522802T1/en active
- 2002-01-28 WO PCT/US2002/002515 patent/WO2002059589A2/en active Application Filing
- 2002-01-28 CA CA2436136A patent/CA2436136C/en not_active Expired - Lifetime
- 2002-01-28 PT PT02714795T patent/PT1354192E/en unknown
- 2002-01-28 AU AU2002247040A patent/AU2002247040A1/en not_active Abandoned
- 2002-01-28 DK DK02714795.8T patent/DK1354192T3/en active
- 2002-01-28 JP JP2002559655A patent/JP2004532384A/en active Pending
- 2002-01-28 EP EP02714795A patent/EP1354192B1/en not_active Expired - Lifetime
- 2002-01-28 CN CNB028056590A patent/CN100533138C/en not_active Expired - Lifetime
- 2002-01-28 ES ES02714795T patent/ES2370633T3/en not_active Expired - Lifetime
- 2002-01-28 TW TW091101408A patent/TWI273238B/en not_active IP Right Cessation
-
2011
- 2011-11-22 CY CY20111101134T patent/CY1112666T1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1354192B1 (en) | 2011-08-31 |
| ATE522802T1 (en) | 2011-09-15 |
| CN100533138C (en) | 2009-08-26 |
| WO2002059589A2 (en) | 2002-08-01 |
| US20020123073A1 (en) | 2002-09-05 |
| PT1354192E (en) | 2011-12-21 |
| TWI273238B (en) | 2007-02-11 |
| CY1112666T1 (en) | 2016-02-10 |
| EP1354192A2 (en) | 2003-10-22 |
| JP2004532384A (en) | 2004-10-21 |
| WO2002059589A3 (en) | 2003-04-10 |
| DK1354192T3 (en) | 2011-12-12 |
| ES2370633T3 (en) | 2011-12-21 |
| AU2002247040A1 (en) | 2002-08-06 |
| CA2436136C (en) | 2010-04-20 |
| US7309409B2 (en) | 2007-12-18 |
| CN1494654A (en) | 2004-05-05 |
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