CA2422267A1 - Drying method for selectively removing volatile components from wet coatings - Google Patents
Drying method for selectively removing volatile components from wet coatings Download PDFInfo
- Publication number
- CA2422267A1 CA2422267A1 CA002422267A CA2422267A CA2422267A1 CA 2422267 A1 CA2422267 A1 CA 2422267A1 CA 002422267 A CA002422267 A CA 002422267A CA 2422267 A CA2422267 A CA 2422267A CA 2422267 A1 CA2422267 A1 CA 2422267A1
- Authority
- CA
- Canada
- Prior art keywords
- substrate
- condensing
- surface temperature
- temperature
- coated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D5/00—Condensation of vapours; Recovering volatile solvents by condensation
- B01D5/0057—Condensation of vapours; Recovering volatile solvents by condensation in combination with other processes
- B01D5/006—Condensation of vapours; Recovering volatile solvents by condensation in combination with other processes with evaporation or distillation
- B01D5/0066—Dome shaped condensation
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B13/00—Machines and apparatus for drying fabrics, fibres, yarns, or other materials in long lengths, with progressive movement
- F26B13/10—Arrangements for feeding, heating or supporting materials; Controlling movement, tension or position of materials
- F26B13/105—Drying webs by contact with heated surfaces other than rollers or drums
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B25/00—Details of general application not covered by group F26B21/00 or F26B23/00
- F26B25/005—Treatment of dryer exhaust gases
- F26B25/006—Separating volatiles, e.g. recovering solvents from dryer exhaust gases
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B3/00—Drying solid materials or objects by processes involving the application of heat
- F26B3/18—Drying solid materials or objects by processes involving the application of heat by conduction, i.e. the heat is conveyed from the heat source, e.g. gas flame, to the materials or objects to be dried by direct contact
- F26B3/20—Drying solid materials or objects by processes involving the application of heat by conduction, i.e. the heat is conveyed from the heat source, e.g. gas flame, to the materials or objects to be dried by direct contact the heat source being a heated surface, e.g. a moving belt or conveyor
Abstract
Method of selectively removing volatile components from a composition, comprising coating the composition onto a first substrate surface of a substrate (38), wherein the composition comprises a nonresident volatile component and a resident volatile component. The method further includes positioning at least a portion of the coated substrate (36) between a condensing surface (32) having a condensing surface temperature (Tc) and a heating surface (34) having a heating surface temperature (TH) that is greater than the condensing surface temperature, wherein the condensing surface (32) is in a spaced apart, confronting relationship to the coated surface (44) of the substrate (38) and wherein the heated surface (34) is in thermal contact with a second substrate surface (42) opposite the first substrate surface. In the method, the heated surface temperature (TH) and the condensing surface temperature (Tc) are such that the positioning step causes the nonresident volatile component to be selectively removed from the portion of the coated substrate. The method is suitable for forming transdermal drug delivery compositions (36).
Claims (22)
1. A method of selectively removing volatile components from a composition, comprising:
coating a coating formulation onto a first substrate surface of a substrate, wherein the coating formulation comprises solvent, one or more volatile ingredients selected from the group consisting of liquid drugs, liquid excipients and mixtures thereof, and if the volatile ingredient is not therapeutically active, one or more drugs, positioning at least a portion of the coated substrate between a condensing surface having a condensing surface temperature and a heating surface having a heating surface temperature that is greater than the condensing surface temperature, wherein the condensing surface is in a spaced apart, confronting relationship to the coated surface of the substrate and wherein the heated surface is in thermal contact with a second substrate surface opposite the first substrate surface; and wherein the heated surface temperature and the condensing surface temperature are such that the positioning causes the solvent to be selectively removed from the portion of the coated substrate.
coating a coating formulation onto a first substrate surface of a substrate, wherein the coating formulation comprises solvent, one or more volatile ingredients selected from the group consisting of liquid drugs, liquid excipients and mixtures thereof, and if the volatile ingredient is not therapeutically active, one or more drugs, positioning at least a portion of the coated substrate between a condensing surface having a condensing surface temperature and a heating surface having a heating surface temperature that is greater than the condensing surface temperature, wherein the condensing surface is in a spaced apart, confronting relationship to the coated surface of the substrate and wherein the heated surface is in thermal contact with a second substrate surface opposite the first substrate surface; and wherein the heated surface temperature and the condensing surface temperature are such that the positioning causes the solvent to be selectively removed from the portion of the coated substrate.
2. The method of claim 1, wherein substantially all of the resident volatile component remains in the portion of the coated substrate.
3. The method of claim 1, wherein the heating surface temperature is within about 20°C of the boiling point of the solvent having the lowest boiling point.
4. The method of claim 3, wherein the heating surface temperature is within about 10°C of the boiling point of the solvent having the lowest boiling point.
5. The method of claim 1, wherein the heating surface has a temperature gradient in which the heating surface temperature increases along the temperature gradient in the longitudinal direction of the heating surface, and wherein the positioning further comprises moving the substrate along the temperature gradient in the longitudinal direction of the heating surface so that successive portions of the substrate come into thermal contact with the heating surface.
6. The method of claim 1, wherein the positioning comprises positioning the substrate within about 1 cm of the condensing surface.
7. The method of claim 1, further comprising:
condensing the vapor on the condensing surface to create a condensate; and removing the condensate from the condensing surface while the condensate remains in the liquid state.
condensing the vapor on the condensing surface to create a condensate; and removing the condensate from the condensing surface while the condensate remains in the liquid state.
8. The method of claim 7, further comprising recovering and collecting the condensate removed from the substrate.
9. The method of claim 1, wherein the solvent is acetone, ethanol, ethyl acetate, heptane, isopropanol, methanol, methyl ethyl ketone, toluene or mixtures thereof.
10. The method of claim 1, wherein the volatile ingredient is a liquid drug.
11. The method of claim 10, wherein the drug is nicotine, nitroglycerin or scopolamine.
12. The method of claim 1, wherein the volatile ingredient is a liquid excipient.
13. The method of claim 12, wherein the excipient is C8-C22 fatty acids, C8-C22 fatty alcohols, C8-C22 fatty diols, lower alkyl esters of C8-C22 fatty acids, di(lower)alkyl esters of C8-C22 fatty acids, monoglycerides of C8-C22 fatty acids, terpenes, tetraglycol, polyethylene glycol ether, polyethylene glycol, propylene glycol, 2-(2-ethoxyethoxy)ethanol, diethylene glycol monomethyl ether or mixtures thereof.
14. The method of claim 13, wherein the excipient is oleyl alcohol, lauryl alcohol, isopropyl myristate, ethyl oleate, methyl laurate, diisopropyl adipate, glyceryl monolaurate, terpineol, tetraglycol, polyethylene glycol, propylene glycol, 2-(2-ethoxyethoxy)ethanol, diethylene glycol monomethyl ether or mixtures thereof.
15. The method of claim 1, wherein the drug is testosterone.
16. The method of claim 1, wherein the coated substrate is a transdermal drug delivery composition.
17. The method of claim 16, wherein the transdermal drug delivery composition further comprises an adhesive.
18. The method of claim 1, wherein the coating formulation further comprises an adhesive.
19. The method of claim 18, wherein the adhesive is an acrylate.
20. The method of claim 1, wherein the substrate comprises a release liner.
21. The method of claim 1, wherein the substrate comprises a backing film.
22. A method of forming a transdermal drug delivery composition, comprising:
coating a coating formulation onto a first substrate surface of a substrate, wherein the coating formulation comprises solvent, one or more volatile ingredients selected from the group consisting of liquid drugs, liquid excipients and mixtures thereof, and if the volatile ingredient is not therapeutically active, one or more drugs, positioning at least a portion of the coated substrate between a condensing surface having a condensing surface temperature and a heating surface having a heating surface temperature that is greater than the condensing surface temperature, wherein the condensing surface is in a spaced apart, confronting relationship to the coated surface of the substrate and wherein the heated surface is in thermal contact with a second substrate surface opposite the first substrate surface; and wherein the heated surface temperature and the condensing surface temperature are such that the positioning causes the solvent to be selectively removed from the portion of the coated substrate such that substantially all of the resident volatile component remains in the portion of the coated substrate.
coating a coating formulation onto a first substrate surface of a substrate, wherein the coating formulation comprises solvent, one or more volatile ingredients selected from the group consisting of liquid drugs, liquid excipients and mixtures thereof, and if the volatile ingredient is not therapeutically active, one or more drugs, positioning at least a portion of the coated substrate between a condensing surface having a condensing surface temperature and a heating surface having a heating surface temperature that is greater than the condensing surface temperature, wherein the condensing surface is in a spaced apart, confronting relationship to the coated surface of the substrate and wherein the heated surface is in thermal contact with a second substrate surface opposite the first substrate surface; and wherein the heated surface temperature and the condensing surface temperature are such that the positioning causes the solvent to be selectively removed from the portion of the coated substrate such that substantially all of the resident volatile component remains in the portion of the coated substrate.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23521800P | 2000-09-24 | 2000-09-24 | |
US60/235,218 | 2000-09-24 | ||
PCT/US2001/042248 WO2002025194A1 (en) | 2000-09-24 | 2001-09-21 | Drying method for selectively removing volatile components from wet coatings |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2422267A1 true CA2422267A1 (en) | 2002-03-28 |
CA2422267C CA2422267C (en) | 2010-02-16 |
Family
ID=22884599
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2422267A Expired - Fee Related CA2422267C (en) | 2000-09-24 | 2001-09-21 | Drying method for selectively removing volatile components from wet coatings |
Country Status (9)
Country | Link |
---|---|
US (1) | US6808739B2 (en) |
EP (1) | EP1320710B1 (en) |
JP (1) | JP2004508912A (en) |
AT (1) | ATE324563T1 (en) |
AU (2) | AU2001295058B2 (en) |
CA (1) | CA2422267C (en) |
DE (1) | DE60119140T2 (en) |
MX (1) | MXPA03002503A (en) |
WO (1) | WO2002025194A1 (en) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8784874B2 (en) * | 2003-09-10 | 2014-07-22 | Noven Pharmaceuticals, Inc. | Multi-layer transdermal drug delivery device |
ME00114B (en) * | 2003-10-28 | 2011-02-10 | Noven Pharma | Compositions and methods for controlling drug loss and delivery in transdermal drug delivery systems |
US20070148218A1 (en) * | 2003-11-18 | 2007-06-28 | Gordon Ryan D | Olanzapine containing transdermal drug delivery compositions |
WO2006041907A2 (en) * | 2004-10-08 | 2006-04-20 | Noven Pharmaceuticals, Inc. | Transdermal delivery of estradiol |
US7273839B2 (en) * | 2004-10-20 | 2007-09-25 | Tarksol International L.L.C. | Method to increase flash points of flammable solvents |
US7877895B2 (en) * | 2006-06-26 | 2011-02-01 | Tokyo Electron Limited | Substrate processing apparatus |
JP5508272B2 (en) * | 2007-10-29 | 2014-05-28 | トランスファーマ メディカル リミテッド | Vertical patch drying |
US8231906B2 (en) | 2008-07-10 | 2012-07-31 | Noven Pharmaceuticals, Inc. | Transdermal estrogen device and delivery |
US8956685B2 (en) * | 2010-02-24 | 2015-02-17 | Monosol Rx, Llc | Use of dams to improve yield in film processing |
CN103890518B (en) | 2011-08-11 | 2016-04-06 | 艾利丹尼森公司 | The method of inerting plate dryer and dry solvent type coating |
EP3685859A4 (en) * | 2017-09-22 | 2021-07-07 | Medrx Co., Ltd. | Non-readherable adhesive patch |
CN108245657A (en) * | 2018-02-12 | 2018-07-06 | 福建省农业科学院亚热带农业研究所(福建省农业科学院蔗麻研究中心) | A kind of anti-corona fragrant spray and preparation method thereof |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT610737A (en) | 1955-11-18 | 1900-01-01 | ||
US4053990A (en) * | 1976-03-03 | 1977-10-18 | Sav-Sol Drying Systems, Inc. | Differential pressure drying and solvent recovery unit |
US4732808A (en) | 1985-11-14 | 1988-03-22 | Minnesota Mining And Manufacturing Company | Macromer reinforced pressure sensitive skin adhesive sheet material |
US6010715A (en) * | 1992-04-01 | 2000-01-04 | Bertek, Inc. | Transdermal patch incorporating a polymer film incorporated with an active agent |
JP4102901B2 (en) * | 1994-09-14 | 2008-06-18 | スリーエム カンパニー | Matrix for transdermal drug introduction |
CA2230709A1 (en) | 1995-09-18 | 1997-03-27 | Minnesota Mining And Manufacturing Company | Component separation system including condensing mechanism |
US5694701A (en) * | 1996-09-04 | 1997-12-09 | Minnesota Mining And Manufacturing Company | Coated substrate drying system |
US5581905A (en) | 1995-09-18 | 1996-12-10 | Minnesota Mining And Manufacturing Company | Coated substrate drying system |
EP1195564B1 (en) * | 1995-09-18 | 2005-12-28 | Minnesota Mining And Manufacturing Company | Coated substrate drying system |
DE19826592A1 (en) * | 1998-06-15 | 1999-12-16 | Lohmann Therapie Syst Lts | Process for producing a laminate consisting of individual layers |
-
2001
- 2001-09-21 CA CA2422267A patent/CA2422267C/en not_active Expired - Fee Related
- 2001-09-21 DE DE60119140T patent/DE60119140T2/en not_active Expired - Lifetime
- 2001-09-21 AU AU2001295058A patent/AU2001295058B2/en not_active Ceased
- 2001-09-21 AU AU9505801A patent/AU9505801A/en active Pending
- 2001-09-21 JP JP2002528754A patent/JP2004508912A/en not_active Ceased
- 2001-09-21 US US09/960,132 patent/US6808739B2/en not_active Expired - Fee Related
- 2001-09-21 MX MXPA03002503A patent/MXPA03002503A/en active IP Right Grant
- 2001-09-21 EP EP01975768A patent/EP1320710B1/en not_active Expired - Lifetime
- 2001-09-21 AT AT01975768T patent/ATE324563T1/en not_active IP Right Cessation
- 2001-09-21 WO PCT/US2001/042248 patent/WO2002025194A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
ATE324563T1 (en) | 2006-05-15 |
AU9505801A (en) | 2002-04-02 |
US20020100185A1 (en) | 2002-08-01 |
DE60119140D1 (en) | 2006-06-01 |
CA2422267C (en) | 2010-02-16 |
EP1320710A1 (en) | 2003-06-25 |
JP2004508912A (en) | 2004-03-25 |
AU2001295058B2 (en) | 2006-06-22 |
US6808739B2 (en) | 2004-10-26 |
EP1320710B1 (en) | 2006-04-26 |
WO2002025194A1 (en) | 2002-03-28 |
MXPA03002503A (en) | 2004-05-24 |
DE60119140T2 (en) | 2007-02-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |