CA2410561A1 - Applicator having abrading surface coated with substance to be applied to skin - Google Patents

Applicator having abrading surface coated with substance to be applied to skin Download PDF

Info

Publication number
CA2410561A1
CA2410561A1 CA002410561A CA2410561A CA2410561A1 CA 2410561 A1 CA2410561 A1 CA 2410561A1 CA 002410561 A CA002410561 A CA 002410561A CA 2410561 A CA2410561 A CA 2410561A CA 2410561 A1 CA2410561 A1 CA 2410561A1
Authority
CA
Canada
Prior art keywords
skin
substance
applicator
delivery
surface coated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002410561A
Other languages
French (fr)
Other versions
CA2410561C (en
Inventor
John A. Mikszta
John M. Brittingham
Jason Alarcon
Ronald J. Pettis
John P. Dekker, Iii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Becton Dickinson and Co
Original Assignee
Becton, Dickinson And Company
John A. Mikszta
John M. Brittingham
Jason Alarcon
Ronald J. Pettis
John P. Dekker, Iii
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton, Dickinson And Company, John A. Mikszta, John M. Brittingham, Jason Alarcon, Ronald J. Pettis, John P. Dekker, Iii filed Critical Becton, Dickinson And Company
Publication of CA2410561A1 publication Critical patent/CA2410561A1/en
Application granted granted Critical
Publication of CA2410561C publication Critical patent/CA2410561C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061—Methods for using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin

Abstract

The present invention provides improved methods for delivery of substances into the skin. It has been discovered that delivery of substances such as nucleic acids, amino acids, amino acid derivatives, peptides and polypeptides simultaneously with abrasion of the skin enhances delivery and the biological response as compared to application of the substance to previously abraded skin.
CA002410561A 2000-05-22 2001-05-18 Applicator having abrading surface coated with substance to be applied to skin Expired - Lifetime CA2410561C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/576,643 2000-05-22
US09/576,643 US6595947B1 (en) 2000-05-22 2000-05-22 Topical delivery of vaccines
PCT/US2001/016121 WO2001089622A1 (en) 2000-05-22 2001-05-18 Applicator having abrading surface coated with substance to be applied to skin

Publications (2)

Publication Number Publication Date
CA2410561A1 true CA2410561A1 (en) 2001-11-29
CA2410561C CA2410561C (en) 2009-05-12

Family

ID=24305324

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002410561A Expired - Lifetime CA2410561C (en) 2000-05-22 2001-05-18 Applicator having abrading surface coated with substance to be applied to skin

Country Status (12)

Country Link
US (3) US6595947B1 (en)
EP (1) EP1289599B1 (en)
JP (1) JP4801309B2 (en)
CN (1) CN100394995C (en)
AT (1) ATE272423T1 (en)
AU (2) AU6175701A (en)
BR (1) BR0111345B1 (en)
CA (1) CA2410561C (en)
DE (1) DE60104686T2 (en)
ES (1) ES2222376T3 (en)
MX (1) MXPA02011557A (en)
WO (1) WO2001089622A1 (en)

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US20040120964A1 (en) * 2001-10-29 2004-06-24 Mikszta John A. Needleless vaccination using chimeric yellow fever vaccine-vectored vaccines against heterologous flaviviruses
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AR040819A1 (en) * 2002-08-08 2005-04-20 Alza Corp VACCINE TRANSDERMAL ADMINISTRATION DEVICE THAT HAS MICROPROJECTIONS COVERED
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Also Published As

Publication number Publication date
CN1430526A (en) 2003-07-16
US7731968B2 (en) 2010-06-08
DE60104686D1 (en) 2004-09-09
WO2001089622A1 (en) 2001-11-29
ES2222376T3 (en) 2005-02-01
EP1289599B1 (en) 2004-08-04
EP1289599A1 (en) 2003-03-12
BR0111345B1 (en) 2010-10-05
CA2410561C (en) 2009-05-12
ATE272423T1 (en) 2004-08-15
AU2001261757B2 (en) 2004-04-01
JP4801309B2 (en) 2011-10-26
JP2003534065A (en) 2003-11-18
DE60104686T2 (en) 2005-08-11
MXPA02011557A (en) 2004-09-06
CN100394995C (en) 2008-06-18
AU6175701A (en) 2001-12-03
US20030191085A1 (en) 2003-10-09
BR0111345A (en) 2004-02-03
US6595947B1 (en) 2003-07-22
US20080009785A1 (en) 2008-01-10

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