CA2406697A1 - Nanodosimeter based on single ion detection - Google Patents

Nanodosimeter based on single ion detection Download PDF

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Publication number
CA2406697A1
CA2406697A1 CA002406697A CA2406697A CA2406697A1 CA 2406697 A1 CA2406697 A1 CA 2406697A1 CA 002406697 A CA002406697 A CA 002406697A CA 2406697 A CA2406697 A CA 2406697A CA 2406697 A1 CA2406697 A1 CA 2406697A1
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CA
Canada
Prior art keywords
positive ions
sensitive
primary particles
radiation
nanodosimeter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002406697A
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French (fr)
Other versions
CA2406697C (en
Inventor
Vladimir Bashkirov
Reinhard W. Schulte
Sergi Shchemelinin
Amos Breskin
Rachel Chechik
Guy Garty
Jamie Milligan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yeda Ltd
Loma Linda University
Original Assignee
Loma Linda University
Vladimir Bashkirov
Reinhard W. Schulte
Sergi Shchemelinin
Amos Breskin
Rachel Chechik
Guy Garty
Jamie Milligan
Yeda Ltd.
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Filing date
Publication date
Application filed by Loma Linda University, Vladimir Bashkirov, Reinhard W. Schulte, Sergi Shchemelinin, Amos Breskin, Rachel Chechik, Guy Garty, Jamie Milligan, Yeda Ltd. filed Critical Loma Linda University
Publication of CA2406697A1 publication Critical patent/CA2406697A1/en
Application granted granted Critical
Publication of CA2406697C publication Critical patent/CA2406697C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/26Mass spectrometers or separator tubes
    • H01J49/34Dynamic spectrometers
    • H01J49/40Time-of-flight spectrometers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/64Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode using wave or particle radiation to ionise a gas, e.g. in an ionisation chamber

Abstract

A nanodosimeter device (15) for de-tecting positive ions induced in a sensitive gas volume by a radiation field of primary particle, comprising an ionization chamber (10) for holding the sensitive gas volume to be irradiated by the radiation field of primary particles, an ion counter system connected to the ionization chamber (10) for detecting the positive ions which pass through the aperture opening and arrive at the ion counter (12) at an arrival time, a particle tracking system for position-sensitive detection of the primary particles passing through the sensitive gas volume, and a data acquisition system capable of coordinating the readout of all data signals and of performing data analysis correlating the arrival time of the positive ions detected by the ion counter system relative to the position sensitive data of primary particles detected by the particle tracking system. The invention further includes the use of the nanodosimeter for method of calibrating radiation exposure with damage to a nucleic acid within a sample. A volume of tissue-equivalent gas is radiated with a radiation field to induce positive ions. The resulting positive ions are measured and compared with a determination of presence or extent of damage resulting from irradiating a nucleic acid sample with an equivalent dose of radiation.
CA002406697A 2000-04-27 2001-04-27 Nanodosimeter based on single ion detection Expired - Lifetime CA2406697C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20053300P 2000-04-27 2000-04-27
US60/200,533 2000-04-27
PCT/US2001/013624 WO2001080980A1 (en) 2000-04-27 2001-04-27 Nanodosimeter based on single ion detection

Publications (2)

Publication Number Publication Date
CA2406697A1 true CA2406697A1 (en) 2001-11-01
CA2406697C CA2406697C (en) 2007-10-02

Family

ID=22742105

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002406697A Expired - Lifetime CA2406697C (en) 2000-04-27 2001-04-27 Nanodosimeter based on single ion detection

Country Status (7)

Country Link
US (2) US6787771B2 (en)
EP (1) EP1289627B1 (en)
AT (1) ATE298085T1 (en)
AU (2) AU2001274814B2 (en)
CA (1) CA2406697C (en)
DE (1) DE60111524T2 (en)
WO (1) WO2001080980A1 (en)

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Also Published As

Publication number Publication date
CA2406697C (en) 2007-10-02
AU7481401A (en) 2001-11-07
DE60111524T2 (en) 2006-07-13
AU2001274814B2 (en) 2004-04-01
WO2001080980A1 (en) 2001-11-01
ATE298085T1 (en) 2005-07-15
US20030146759A1 (en) 2003-08-07
EP1289627B1 (en) 2005-06-15
US6787771B2 (en) 2004-09-07
EP1289627A1 (en) 2003-03-12
DE60111524D1 (en) 2005-07-21
US20050109929A1 (en) 2005-05-26
US7081619B2 (en) 2006-07-25
EP1289627A4 (en) 2003-09-03

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