CA2386379A1 - Carbonyl stress-decreasing agent - Google Patents

Carbonyl stress-decreasing agent Download PDF

Info

Publication number
CA2386379A1
CA2386379A1 CA002386379A CA2386379A CA2386379A1 CA 2386379 A1 CA2386379 A1 CA 2386379A1 CA 002386379 A CA002386379 A CA 002386379A CA 2386379 A CA2386379 A CA 2386379A CA 2386379 A1 CA2386379 A1 CA 2386379A1
Authority
CA
Canada
Prior art keywords
agent
carbonyl stress
carbonyl
stress
decreasing agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002386379A
Other languages
French (fr)
Other versions
CA2386379C (en
Inventor
Toshio Miyata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tokai University Educational Systems
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2386379A1 publication Critical patent/CA2386379A1/en
Application granted granted Critical
Publication of CA2386379C publication Critical patent/CA2386379C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Agents for relieving carbonyl stress which comprise biguanides such as metoformin. By administering orally or the like, these agents are usable as drugs directly acting on carboxyl stress in vivo.

Claims (5)

1. A carbonyl stress-decreasing agent comprising a biguanide agent or pharmacologically acceptable salt thereof as an active ingredient.
2. The carbonyl stress-decreasing agent of claim 1, wherein the biguanide agent is a compound selected from the group consisting of: phenformin, metformin, buformin, and pharmacologically acceptable salts thereof.
3. A carrier, on which a biguanide agent has been immobilized.
4. An adsorbent of carbonyl compounds comprising the carrier of claim 3.
5. A method for removing carbonyl compounds comprising the step of contacting the carrier of claim 3 with a body fluid selected from the group consisting of : blood, blood plasma and peritoneal dialysate.
CA002386379A 1999-10-06 2000-10-06 Carbonyl stress-decreasing agent Expired - Fee Related CA2386379C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP28573599 1999-10-06
JP11/285735 1999-10-06
PCT/JP2000/006987 WO2001024790A1 (en) 1999-10-06 2000-10-06 Agents for relieving carbonyl stress

Publications (2)

Publication Number Publication Date
CA2386379A1 true CA2386379A1 (en) 2001-04-12
CA2386379C CA2386379C (en) 2009-12-15

Family

ID=17695374

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002386379A Expired - Fee Related CA2386379C (en) 1999-10-06 2000-10-06 Carbonyl stress-decreasing agent

Country Status (9)

Country Link
US (1) US7169407B1 (en)
EP (1) EP1228756A4 (en)
JP (1) JP4719393B2 (en)
KR (1) KR100758073B1 (en)
CN (1) CN1287779C (en)
AU (1) AU780855B2 (en)
CA (1) CA2386379C (en)
NO (1) NO20021612L (en)
WO (1) WO2001024790A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2070535B1 (en) 1998-08-24 2015-07-08 Kurokawa, Kiyoshi Drugs for relieving carbonyl stress and peritoneal dialysates
WO2002047677A1 (en) * 2000-12-12 2002-06-20 Tokai University Educational System Agents for ameliorating carbonyl stress
US8652582B2 (en) 2008-05-30 2014-02-18 3M Innovative Properties Company Method of making ligand functionalized substrates
CN102105213B (en) 2008-05-30 2013-12-18 3M创新有限公司 Ligand functionalized substrates
WO2010033794A1 (en) 2008-09-19 2010-03-25 3M Innovative Properties Company Ligand graft functionalized substrates
CN102803593A (en) 2009-06-23 2012-11-28 3M创新有限公司 Functionalized nonwoven article
US8377672B2 (en) 2010-02-18 2013-02-19 3M Innovative Properties Company Ligand functionalized polymers
CN102844662B (en) 2010-03-03 2015-04-29 3M创新有限公司 Ligand functionalized polymers
KR101627409B1 (en) * 2014-05-23 2016-06-03 이화여자대학교 산학협력단 Pharmaceutical composition comprising metformin as an active ingredient and use thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH602612A5 (en) 1974-10-11 1978-07-31 Hoffmann La Roche
JPS6440418A (en) * 1987-08-07 1989-02-10 Arusu Japan Kk Sustained release material for drug
TW438587B (en) * 1995-06-20 2001-06-07 Takeda Chemical Industries Ltd A pharmaceutical composition for prophylaxis and treatment of diabetes
US5928916A (en) * 1996-04-25 1999-07-27 Medtronic, Inc. Ionic attachment of biomolecules with a guanidino moiety to medical device surfaces
JPH111493A (en) * 1997-06-12 1999-01-06 Kuraray Co Ltd Peptide and medical material obtained by immobilizing the same
JP3101711B2 (en) * 1997-11-20 2000-10-23 農林水産省蚕糸・昆虫農業技術研究所長 Adsorbent / sustained-release body comprising biopolymer and method for producing the same
EP2070535B1 (en) 1998-08-24 2015-07-08 Kurokawa, Kiyoshi Drugs for relieving carbonyl stress and peritoneal dialysates
US6117451A (en) * 1998-08-25 2000-09-12 Pharmalogix, Inc. Direct compression metformin hydrochloride tablets
AU778462C (en) 1999-05-12 2006-02-02 Kurokawa, Kiyoshi Blood carbonyl compound-trapping agent
US6559188B1 (en) * 1999-09-17 2003-05-06 Novartis Ag Method of treating metabolic disorders especially diabetes, or a disease or condition associated with diabetes

Also Published As

Publication number Publication date
US7169407B1 (en) 2007-01-30
WO2001024790A1 (en) 2001-04-12
NO20021612D0 (en) 2002-04-05
EP1228756A1 (en) 2002-08-07
CN1402635A (en) 2003-03-12
NO20021612L (en) 2002-06-05
CA2386379C (en) 2009-12-15
AU780855B2 (en) 2005-04-21
AU7558000A (en) 2001-05-10
CN1287779C (en) 2006-12-06
EP1228756A4 (en) 2004-06-09
JP4719393B2 (en) 2011-07-06
KR100758073B1 (en) 2007-09-11
KR20020038790A (en) 2002-05-23

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20151006