CA2383912A1 - Automated parallel capillary electrophoresis system with hydrodynamic sample injection - Google Patents
Automated parallel capillary electrophoresis system with hydrodynamic sample injection Download PDFInfo
- Publication number
- CA2383912A1 CA2383912A1 CA002383912A CA2383912A CA2383912A1 CA 2383912 A1 CA2383912 A1 CA 2383912A1 CA 002383912 A CA002383912 A CA 002383912A CA 2383912 A CA2383912 A CA 2383912A CA 2383912 A1 CA2383912 A1 CA 2383912A1
- Authority
- CA
- Canada
- Prior art keywords
- capillary
- container
- liquid
- samples
- zone electrophoresis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/24—Extraction; Separation; Purification by electrochemical means
- C07K1/26—Electrophoresis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44743—Introducing samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44756—Apparatus specially adapted therefor
- G01N27/44782—Apparatus specially adapted therefor of a plurality of samples
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/2575—Volumetric liquid transfer
Abstract
An automated capillary zone electrophoretic system is disclosed. The system employs a capillary cartridge (102) having a plurality of capillary tubes. T he cartridge has a first array of capillary ends (108) projecting from one side of a plate. The first array of capillary ends (108) are spaced apart in substantially the same manner as the wells of a microtitre tray of standard size. The system also a container (100) connected to the detection end of th e capillaries (107). The container is provided with valving (116, 120, 124, 12 8, 134) which facilitates cleaning the capillaries, loading buffer into the capillaries, introducing samples to be electrophoresced into the capillaries , and performing capillary zone electrophoresis on the thus introduced samples .
Claims (19)
1. An automated parallel capillary zone electrophoresis system for performing capillary zone electrophoresis on a plurality of samples, said system comprising:
a fluid container;
a plurality of capillary tubes, each capillary tube having a first end and a second end, said first ends having a spacing corresponding to that of wells of a microtitre tray, said second ends connected to said fluid container at a first level therein;
a pump connected to said fluid container via a pump conduit, said pump configured to introduce a liquid into the container when said conduit is open and said pump is operating;
a vacuum device connected to said fluid container via a vacuum conduit entering said fluid container at a second level higher than said first level, said vacuum device configured to cause a negative pressure in said airspace, when said pump conduit is closed and said container is sealed;
a gas release valve connected to said container and configured to vent a gas in the container when said gas release valve is opened;
a drain valve connected to said container and configured to drain a liquid in said container, when said drain valve is open;
a light source arranged to illuminate samples within said plurality of capillary tubes; and a light detector configured to detect a light emitted by said samples.
a fluid container;
a plurality of capillary tubes, each capillary tube having a first end and a second end, said first ends having a spacing corresponding to that of wells of a microtitre tray, said second ends connected to said fluid container at a first level therein;
a pump connected to said fluid container via a pump conduit, said pump configured to introduce a liquid into the container when said conduit is open and said pump is operating;
a vacuum device connected to said fluid container via a vacuum conduit entering said fluid container at a second level higher than said first level, said vacuum device configured to cause a negative pressure in said airspace, when said pump conduit is closed and said container is sealed;
a gas release valve connected to said container and configured to vent a gas in the container when said gas release valve is opened;
a drain valve connected to said container and configured to drain a liquid in said container, when said drain valve is open;
a light source arranged to illuminate samples within said plurality of capillary tubes; and a light detector configured to detect a light emitted by said samples.
2. The automated capillary zone electrophoresis system of claim 1, further comprising:
an overflow conduit connected to said container, said overflow conduit configured to release liquid held within the container, when a height of said liquid within the container exceeds a predetermined level.
an overflow conduit connected to said container, said overflow conduit configured to release liquid held within the container, when a height of said liquid within the container exceeds a predetermined level.
3. The automated capillary zone electrophoresis system of claim 2, further comprising:
an overflow valve positioned in said overflow conduit, said overflow valve having at least a first, open position, and a second, closed position.
an overflow valve positioned in said overflow conduit, said overflow valve having at least a first, open position, and a second, closed position.
4. The automated capillary zone electrophoresis system of claim 1, wherein said suction device is a syringe.
5. The automated capillary zone electrophoresis system of claim 1, wherein said capillary first ends are arranged in a two-dimensional array having a spacing corresponding to that of wells of a microtitre tray, said system further comprising:
a positioning apparatus comprising an upper and a lower carrousel carrying microtitre trays, said positioning apparatus arranged to position one of said microtitre trays such that said two dimensional array of capillary first ends is inserted into corresponding wells of said microtitre tray.
a positioning apparatus comprising an upper and a lower carrousel carrying microtitre trays, said positioning apparatus arranged to position one of said microtitre trays such that said two dimensional array of capillary first ends is inserted into corresponding wells of said microtitre tray.
6. An automated parallel capillary zone electrophoresis system for performing capillary zone electrophoresis on a plurality of samples, said system comprising:
a fluid container;
a plurality of capillary tubes, each capillary tube having a first end and a second end, said first ends having a spacing corresponding to that of wells of a microtitre tray, said second ends connected to said fluid container at a first level therein;
a pump connected to said fluid container via a pump conduit, said pump configured to introduce a liquid into the container when said conduit is open and said pump is operating;
a vacuum device connected to said fluid container via a vacuum conduit entering said fluid container at a second level higher than said first level, said vacuum device configured to cause a negative pressure in said airspace, when said pump conduit is closed and said container is sealed;
a light source arranged to illuminate samples within said plurality of capillary tubes; and a light detector configured to detect a light emitted by said samples.
a fluid container;
a plurality of capillary tubes, each capillary tube having a first end and a second end, said first ends having a spacing corresponding to that of wells of a microtitre tray, said second ends connected to said fluid container at a first level therein;
a pump connected to said fluid container via a pump conduit, said pump configured to introduce a liquid into the container when said conduit is open and said pump is operating;
a vacuum device connected to said fluid container via a vacuum conduit entering said fluid container at a second level higher than said first level, said vacuum device configured to cause a negative pressure in said airspace, when said pump conduit is closed and said container is sealed;
a light source arranged to illuminate samples within said plurality of capillary tubes; and a light detector configured to detect a light emitted by said samples.
7. The automated capillary zone electrophoresis system of claim 6, further comprising:
a gas release valve connected to said container and configured to vent a gas in the container when said gas release valve is opened;
a gas release valve connected to said container and configured to vent a gas in the container when said gas release valve is opened;
8. The automated capillary zone electrophoresis system of claim 7, further comprising:
a drain valve connected to said container and configured to drain a liquid in said container, when said drain valve is open.
a drain valve connected to said container and configured to drain a liquid in said container, when said drain valve is open.
9. The automated capillary zone electrophoresis system of claim 8, further comprising:
an overflow conduit connected to said container, said overflow conduit configured to release liquid held within the container, when a height of said liquid within the container exceeds a predetermined level.
an overflow conduit connected to said container, said overflow conduit configured to release liquid held within the container, when a height of said liquid within the container exceeds a predetermined level.
10. The automated capillary zone electrophoresis system of claim 9, further comprising:
an overflow valve positioned in said overflow conduit, said overflow valve having at least a first, open position, and a second, closed position.
an overflow valve positioned in said overflow conduit, said overflow valve having at least a first, open position, and a second, closed position.
11. The automated capillary zone electrophoresis system of claim 6, wherein said capillary first ends are arranged in a two-dimensional array having a spacing corresponding to that of well of a microtitre tray, said system further comprising:
a positioning apparatus comprising an upper and a lower carrousel carrying microtitre trays, said positioning apparatus arranged to position one of said microtitre trays such that said two dimensional array of capillary first ends is inserted into corresponding wells of said microtitre tray.
a positioning apparatus comprising an upper and a lower carrousel carrying microtitre trays, said positioning apparatus arranged to position one of said microtitre trays such that said two dimensional array of capillary first ends is inserted into corresponding wells of said microtitre tray.
12. The automated capillary zone electrophoresis system of claim 6, wherein said suction device is a syringe.
13. The automated capillary zone electrophoresis system of claim 6, wherein said suction device is a drain conduit provided with a valve member positioned at a height below a height of said capillary first ends, whereby a gravity flow of liquid through said drain conduit by gravity causes a negative pressure in said container, thereby siphoning samples into each of said plurality of capillary tube first ends.
14. A method for automated parallel capillary zone electrophoresis on a plurality of samples, said method comprising:
providing a fluid container;
providing a plurality of capillary tubes, each capillary tube having a first end and a second end, said first ends having a spacing corresponding to that of wells of a microtitre tray, said second ends connected to said fluid container at a first level therein;
introducing a first liquid into said fluid container to a height at least as high as said first level;
applying a negative pressure to said capillary second ends to hydrodynamically introduce a sample to be electrophoresced into each of said capillary first ends;
applying a voltage differential between said capillary first ends and said capillary second ends to cause said samples to migrate towards said capillary second ends through electro-osmotic flow; and detecting a light emitted by said samples after said samples have migrated at least part-way toward said capillary second ends.
providing a fluid container;
providing a plurality of capillary tubes, each capillary tube having a first end and a second end, said first ends having a spacing corresponding to that of wells of a microtitre tray, said second ends connected to said fluid container at a first level therein;
introducing a first liquid into said fluid container to a height at least as high as said first level;
applying a negative pressure to said capillary second ends to hydrodynamically introduce a sample to be electrophoresced into each of said capillary first ends;
applying a voltage differential between said capillary first ends and said capillary second ends to cause said samples to migrate towards said capillary second ends through electro-osmotic flow; and detecting a light emitted by said samples after said samples have migrated at least part-way toward said capillary second ends.
15. The method according to claim 14, further comprising:
flowing a liquid past said capillary second ends while applying said voltage differential.
flowing a liquid past said capillary second ends while applying said voltage differential.
16. The method according to claim 14, wherein the step of applying a negative pressure comprises:
withdrawing air in said liquid container at a point above a level of said liquid while said container is sealed, thereby causing samples to enter said capillary first ends.
withdrawing air in said liquid container at a point above a level of said liquid while said container is sealed, thereby causing samples to enter said capillary first ends.
17. The method according to claim 16, wherein the step of withdrawing air comprises:
retracting a plunger of a syringe connected to said liquid container.
retracting a plunger of a syringe connected to said liquid container.
18. The method according to claim 17, further comprising:
flowing a liquid past said capillary second ends while applying said voltage differential.
flowing a liquid past said capillary second ends while applying said voltage differential.
19. The method according to claim 14, wherein the step of applying a negative pressure comprises:
draining a portion of a liquid in said liquid container, such that samples are siphoned into said capillary first ends.
draining a portion of a liquid in said liquid container, such that samples are siphoned into said capillary first ends.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/388,125 | 1999-08-31 | ||
| US09/388,125 US6352633B1 (en) | 1999-08-31 | 1999-08-31 | Automated parallel capillary electrophoresis system with hydrodynamic sample injection |
| PCT/US2000/023709 WO2001016587A1 (en) | 1999-08-31 | 2000-08-29 | Automated parallel capillary electrophoresis system with hydrodynamic sample injection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2383912A1 true CA2383912A1 (en) | 2001-03-08 |
| CA2383912C CA2383912C (en) | 2009-11-10 |
Family
ID=23532811
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002383912A Expired - Fee Related CA2383912C (en) | 1999-08-31 | 2000-08-29 | Automated parallel capillary electrophoresis system with hydrodynamic sample injection |
Country Status (5)
| Country | Link |
|---|---|
| US (6) | US6352633B1 (en) |
| EP (1) | EP1212608A4 (en) |
| JP (1) | JP2003508749A (en) |
| CA (1) | CA2383912C (en) |
| WO (1) | WO2001016587A1 (en) |
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| US7983349B2 (en) | 2001-03-20 | 2011-07-19 | Lightwaves Systems, Inc. | High bandwidth data transport system |
| WO2003087773A2 (en) * | 2002-04-12 | 2003-10-23 | Amersham Biosciences (Sv) Corp | Multiplexed capillary electrophoresis systems |
| US6833919B2 (en) * | 2002-10-11 | 2004-12-21 | Combisep | Multiplexed, absorbance-based capillary electrophoresis system and method |
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-
1999
- 1999-08-31 US US09/388,125 patent/US6352633B1/en not_active Expired - Lifetime
-
2000
- 2000-08-29 JP JP2001520093A patent/JP2003508749A/en active Pending
- 2000-08-29 EP EP00959564A patent/EP1212608A4/en not_active Withdrawn
- 2000-08-29 WO PCT/US2000/023709 patent/WO2001016587A1/en not_active Application Discontinuation
- 2000-08-29 CA CA002383912A patent/CA2383912C/en not_active Expired - Fee Related
-
2001
- 2001-12-11 US US10/011,977 patent/US6953521B2/en not_active Expired - Lifetime
-
2005
- 2005-08-15 US US11/204,773 patent/US7459070B2/en not_active Expired - Lifetime
-
2008
- 2008-10-27 US US12/290,087 patent/US20090090630A1/en not_active Abandoned
-
2009
- 2009-12-09 US US12/634,661 patent/US20100147692A1/en not_active Abandoned
-
2011
- 2011-03-15 US US13/048,846 patent/US20110220508A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US6953521B2 (en) | 2005-10-11 |
| US20020040850A1 (en) | 2002-04-11 |
| US20110220508A1 (en) | 2011-09-15 |
| US6352633B1 (en) | 2002-03-05 |
| EP1212608A1 (en) | 2002-06-12 |
| US20090090630A1 (en) | 2009-04-09 |
| JP2003508749A (en) | 2003-03-04 |
| US7459070B2 (en) | 2008-12-02 |
| EP1212608A4 (en) | 2006-09-06 |
| CA2383912C (en) | 2009-11-10 |
| US20100147692A1 (en) | 2010-06-17 |
| WO2001016587A1 (en) | 2001-03-08 |
| US20060091011A1 (en) | 2006-05-04 |
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Effective date: 20120829 |