CA2381594A1 - Method for inactivation of microorganisms using photosensitizers - Google Patents

Method for inactivation of microorganisms using photosensitizers Download PDF

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Publication number
CA2381594A1
CA2381594A1 CA002381594A CA2381594A CA2381594A1 CA 2381594 A1 CA2381594 A1 CA 2381594A1 CA 002381594 A CA002381594 A CA 002381594A CA 2381594 A CA2381594 A CA 2381594A CA 2381594 A1 CA2381594 A1 CA 2381594A1
Authority
CA
Canada
Prior art keywords
fluid
microorganisms
photosensitizer
inactivation
photosensitizers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002381594A
Other languages
French (fr)
Other versions
CA2381594C (en
Inventor
Raymond Paul Goodrich Jr.
Dennis Hlavinka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Terumo BCT Biotechnologies LLC
Original Assignee
Raymond Paul Goodrich Jr.
Dennis Hlavinka
Gambro, Inc.
Navigant Biotechnologies, Inc.
Navigant Biotechnologies, Llc
Caridianbct Biotechnologies, Llc
Terumo Bct Biotechnologies, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Raymond Paul Goodrich Jr., Dennis Hlavinka, Gambro, Inc., Navigant Biotechnologies, Inc., Navigant Biotechnologies, Llc, Caridianbct Biotechnologies, Llc, Terumo Bct Biotechnologies, Llc filed Critical Raymond Paul Goodrich Jr.
Publication of CA2381594A1 publication Critical patent/CA2381594A1/en
Application granted granted Critical
Publication of CA2381594C publication Critical patent/CA2381594C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0029—Radiation
    • A61L2/0076—Radiation using a photocatalyst or photosensitiser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A61L2/0088—Liquid substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/08—Radiation
    • A61L2/10—Ultra-violet radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/20—Targets to be treated
    • A61L2202/22—Blood or products thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

Methods and apparatuses for treating fluids to inactivate microorganisms which may be present therein, said fluid containing one or more components selected from the group consisting of protein, blood and blood constituents are provided.
The methods comprise adjusting the percentage of plasma in said fluid to a desired value; mixing an inactivation-effective, substantially non-toxic amount of an endogenous photosensitizer or endogenously-based derivative photosensitizer to said fluid; exposing said fluid to photoradiation of sufficient wavelength and energy to activate the photosensitizer, whereby said microorganisms are inactivated.
CA002381594A 2000-06-15 2001-06-08 Method for inactivation of microorganisms using photosensitizers Expired - Lifetime CA2381594C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/596,429 US7094378B1 (en) 2000-06-15 2000-06-15 Method and apparatus for inactivation of biological contaminants using photosensitizers
US09/596,429 2000-06-15
PCT/US2001/018752 WO2001096340A1 (en) 2000-06-15 2001-06-08 Method for inactivation of microorganisms using photosensitizers

Publications (2)

Publication Number Publication Date
CA2381594A1 true CA2381594A1 (en) 2001-12-20
CA2381594C CA2381594C (en) 2009-03-24

Family

ID=24387230

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002381594A Expired - Lifetime CA2381594C (en) 2000-06-15 2001-06-08 Method for inactivation of microorganisms using photosensitizers

Country Status (7)

Country Link
US (1) US7094378B1 (en)
EP (1) EP1289991B1 (en)
AT (1) ATE343579T1 (en)
AU (1) AU2001266829A1 (en)
CA (1) CA2381594C (en)
DE (1) DE60124095T2 (en)
WO (1) WO2001096340A1 (en)

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US8986944B2 (en) * 2001-10-11 2015-03-24 Aviva Biosciences Corporation Methods and compositions for separating rare cells from fluid samples
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DE60327166D1 (en) * 2002-02-01 2009-05-28 Caridianbct Biotechnologies Ll REDUCTION OF INFLUENCES IN BLOOD AND BLOOD PRODUCTS THROUGH THE USE OF PHOTOACTIVE SUBSTANCES AND IRRADIATION WITH LIGHT OF A TIGHT WAVELENGE RANGE
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EP1289991B1 (en) 2006-10-25
DE60124095T2 (en) 2007-06-06
AU2001266829A1 (en) 2001-12-24
WO2001096340A1 (en) 2001-12-20
ATE343579T1 (en) 2006-11-15
US7094378B1 (en) 2006-08-22
CA2381594C (en) 2009-03-24
EP1289991A1 (en) 2003-03-12

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