CA2377293A1 - Real-time monitoring of photodynamic therapy over an extended time - Google Patents

Real-time monitoring of photodynamic therapy over an extended time Download PDF

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Publication number
CA2377293A1
CA2377293A1 CA002377293A CA2377293A CA2377293A1 CA 2377293 A1 CA2377293 A1 CA 2377293A1 CA 002377293 A CA002377293 A CA 002377293A CA 2377293 A CA2377293 A CA 2377293A CA 2377293 A1 CA2377293 A1 CA 2377293A1
Authority
CA
Canada
Prior art keywords
time
treatment site
administered
light
ultrasound images
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002377293A
Other languages
French (fr)
Other versions
CA2377293C (en
Inventor
James C. Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euro Celtique SA
Original Assignee
Light Sciences Corporation
James C. Chen
Light Sciences Limited Partnership
Light Sciences, Llc
Light Sciences Oncology, Inc.
Euro-Celtique S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Light Sciences Corporation, James C. Chen, Light Sciences Limited Partnership, Light Sciences, Llc, Light Sciences Oncology, Inc., Euro-Celtique S.A. filed Critical Light Sciences Corporation
Publication of CA2377293A1 publication Critical patent/CA2377293A1/en
Application granted granted Critical
Publication of CA2377293C publication Critical patent/CA2377293C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/06—Measuring blood flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
    • A61B8/0833—Detecting organic movements or changes, e.g. tumours, cysts, swellings involving detecting or locating foreign bodies or organic structures

Abstract

Progress of photodynamic therapy (PDT) administered over an extended period of time is monitored using an ultrasonic probe (30), which produces ultrasound images of an internal treatment site in real time. The ultrasound images indicate the extent and volume of an infraction zone within a tumor (20) or other diseased tissue at the internal treatment site within a patient's body. Light is administered to the internal treatment site from either an internal or external light source that produces light in a waveband corresponding to the characteristic absorption waveband a photoreactive agent that is administered to a patient. Prior to or shortly after initiating administration of the light therapy, a baseline ultrasound image is produced for comparison to subsequent ultrasound images made after the effects of the PDT on the diseased tissue have occurred.
CA002377293A 1999-07-19 2000-05-26 Real-time monitoring of photodynamic therapy over an extended time Expired - Lifetime CA2377293C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/356,938 US6238426B1 (en) 1999-07-19 1999-07-19 Real-time monitoring of photodynamic therapy over an extended time
US09/356,938 1999-07-19
PCT/US2000/014584 WO2001005316A1 (en) 1999-07-19 2000-05-26 Real-time monitoring of photodynamic therapy over an extended time

Publications (2)

Publication Number Publication Date
CA2377293A1 true CA2377293A1 (en) 2001-01-25
CA2377293C CA2377293C (en) 2007-10-30

Family

ID=23403593

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002377293A Expired - Lifetime CA2377293C (en) 1999-07-19 2000-05-26 Real-time monitoring of photodynamic therapy over an extended time

Country Status (6)

Country Link
US (1) US6238426B1 (en)
EP (1) EP1199996A4 (en)
JP (1) JP2003525074A (en)
AU (1) AU757479B2 (en)
CA (1) CA2377293C (en)
WO (1) WO2001005316A1 (en)

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US10376711B2 (en) * 2003-03-14 2019-08-13 Light Sciences Oncology Inc. Light generating guide wire for intravascular use
US20080269846A1 (en) * 2003-03-14 2008-10-30 Light Sciences Oncology, Inc. Device for treatment of blood vessels using light
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US20110009464A1 (en) * 2009-07-09 2011-01-13 Light Sciences Oncology, Inc. Immune system stimulation by light therapy induced apoptotic cell death in abnormal tissue
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Also Published As

Publication number Publication date
AU757479B2 (en) 2003-02-20
AU5295600A (en) 2001-02-05
WO2001005316A1 (en) 2001-01-25
EP1199996A1 (en) 2002-05-02
EP1199996A4 (en) 2009-01-14
JP2003525074A (en) 2003-08-26
US6238426B1 (en) 2001-05-29
CA2377293C (en) 2007-10-30

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Effective date: 20200526