CA2376283A1 - Method of manufacturing an intracutaneous microneedle array - Google Patents

Method of manufacturing an intracutaneous microneedle array Download PDF

Info

Publication number
CA2376283A1
CA2376283A1 CA002376283A CA2376283A CA2376283A1 CA 2376283 A1 CA2376283 A1 CA 2376283A1 CA 002376283 A CA002376283 A CA 002376283A CA 2376283 A CA2376283 A CA 2376283A CA 2376283 A1 CA2376283 A1 CA 2376283A1
Authority
CA
Canada
Prior art keywords
mold
metal
procedure
microneedle array
microneedles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002376283A
Other languages
French (fr)
Other versions
CA2376283C (en
Inventor
Faiz F. Sherman
Vadim Vladimirovich Yuzhakov
Vladimir Gartstein
Grover David Owens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Corium Inc
Original Assignee
Faiz F. Sherman
Vadim Vladimirovich Yuzhakov
Vladimir Gartstein
Grover David Owens
The Procter & Gamble Company
Corium International Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Faiz F. Sherman, Vadim Vladimirovich Yuzhakov, Vladimir Gartstein, Grover David Owens, The Procter & Gamble Company, Corium International Inc. filed Critical Faiz F. Sherman
Priority to CA002591168A priority Critical patent/CA2591168C/en
Publication of CA2376283A1 publication Critical patent/CA2376283A1/en
Application granted granted Critical
Publication of CA2376283C publication Critical patent/CA2376283C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C51/00—Shaping by thermoforming, i.e. shaping sheets or sheet like preforms after heating, e.g. shaping sheets in matched moulds or by deep-drawing; Apparatus therefor
    • B29C51/08—Deep drawing or matched-mould forming, i.e. using mechanical means only
    • B29C51/082—Deep drawing or matched-mould forming, i.e. using mechanical means only by shaping between complementary mould parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B26—HAND CUTTING TOOLS; CUTTING; SEVERING
    • B26F—PERFORATING; PUNCHING; CUTTING-OUT; STAMPING-OUT; SEVERING BY MEANS OTHER THAN CUTTING
    • B26F1/00—Perforating; Punching; Cutting-out; Stamping-out; Apparatus therefor
    • B26F1/24—Perforating by needles or pins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C33/00—Moulds or cores; Details thereof or accessories therefor
    • B29C33/0033—Moulds or cores; Details thereof or accessories therefor constructed for making articles provided with holes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C33/00—Moulds or cores; Details thereof or accessories therefor
    • B29C33/42—Moulds or cores; Details thereof or accessories therefor characterised by the shape of the moulding surface, e.g. ribs or grooves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C37/00—Component parts, details, accessories or auxiliary operations, not covered by group B29C33/00 or B29C35/00
    • B29C37/0053—Moulding articles characterised by the shape of the surface, e.g. ribs, high polish
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/17—Component parts, details or accessories; Auxiliary operations
    • B29C45/26—Moulds
    • B29C45/2628—Moulds with mould parts forming holes in or through the moulded article, e.g. for bearing cages
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C51/00—Shaping by thermoforming, i.e. shaping sheets or sheet like preforms after heating, e.g. shaping sheets in matched moulds or by deep-drawing; Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C1/00—Manufacture or treatment of devices or systems in or on a substrate
    • B81C1/00015—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems
    • B81C1/00023—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems without movable or flexible elements
    • B81C1/00111—Tips, pillars, i.e. raised structures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C59/00—Surface shaping of articles, e.g. embossing; Apparatus therefor
    • B29C59/02—Surface shaping of articles, e.g. embossing; Apparatus therefor by mechanical means, e.g. pressing
    • B29C59/022—Surface shaping of articles, e.g. embossing; Apparatus therefor by mechanical means, e.g. pressing characterised by the disposition or the configuration, e.g. dimensions, of the embossments or the shaping tools therefor
    • B29C2059/023—Microembossing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/753—Medical equipment; Accessories therefor
    • B29L2031/7544—Injection needles, syringes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/756—Microarticles, nanoarticles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B2201/00—Specific applications of microelectromechanical systems
    • B81B2201/05—Microfluidics
    • B81B2201/055—Microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C2201/00—Manufacture or treatment of microstructural devices or systems
    • B81C2201/03—Processes for manufacturing substrate-free structures
    • B81C2201/036—Hot embossing

Abstract

A microneedle array is manufactured using a mold preparation procedure that begins by placing an optical mask over a layer of PMMA
material, exposing the PMMA
material to x-rays, then developing using a photoresist process. The remaining PMMA material is then electroplated with metal. Once the metal has reached an appropriate thickness, it is detached to become a metal mold that is used in a microembossing procedure, in which the metal mold is pressed against a heated layer of plastic material. Once the mold is pressed down to its proper distance, the plastic material is cooled until solidified, and the mold is then detached, thereby leaving behind an array of microneedles. If the microneedles are hollow, then an additional procedure is used to create through-holes all the way through the underlying substrate material using laser optical means.
CA002376283A 1999-06-09 2000-06-07 Method of manufacturing an intracutaneous microneedle array Expired - Fee Related CA2376283C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002591168A CA2591168C (en) 1999-06-09 2000-06-07 Method of manufacturing an intracutaneous microneedle array

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/328,946 US6312612B1 (en) 1999-06-09 1999-06-09 Apparatus and method for manufacturing an intracutaneous microneedle array
US09/328,946 1999-06-09
PCT/US2000/015612 WO2000074764A1 (en) 1999-06-09 2000-06-07 Method of manufacturing an intracutaneous microneedle array

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA002591168A Division CA2591168C (en) 1999-06-09 2000-06-07 Method of manufacturing an intracutaneous microneedle array

Publications (2)

Publication Number Publication Date
CA2376283A1 true CA2376283A1 (en) 2000-12-14
CA2376283C CA2376283C (en) 2007-08-28

Family

ID=23283160

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002376283A Expired - Fee Related CA2376283C (en) 1999-06-09 2000-06-07 Method of manufacturing an intracutaneous microneedle array
CA2689890A Expired - Fee Related CA2689890C (en) 1999-06-09 2000-06-07 Method of manufacturing an intracutaneous microneedle array

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2689890A Expired - Fee Related CA2689890C (en) 1999-06-09 2000-06-07 Method of manufacturing an intracutaneous microneedle array

Country Status (7)

Country Link
US (3) US6312612B1 (en)
EP (1) EP1183064B1 (en)
JP (1) JP4436992B2 (en)
AU (1) AU5727900A (en)
CA (2) CA2376283C (en)
TW (1) TW512067B (en)
WO (1) WO2000074764A1 (en)

Families Citing this family (485)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6797276B1 (en) 1996-11-14 2004-09-28 The United States Of America As Represented By The Secretary Of The Army Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
US20060002949A1 (en) 1996-11-14 2006-01-05 Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. Transcutaneous immunization without heterologous adjuvant
US6036924A (en) 1997-12-04 2000-03-14 Hewlett-Packard Company Cassette of lancet cartridges for sampling blood
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US7344499B1 (en) * 1998-06-10 2008-03-18 Georgia Tech Research Corporation Microneedle device for extraction and sensing of bodily fluids
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6743211B1 (en) * 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6379324B1 (en) 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6312612B1 (en) 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US20030078499A1 (en) * 1999-08-12 2003-04-24 Eppstein Jonathan A. Microporation of tissue for delivery of bioactive agents
US6835184B1 (en) 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
US6331266B1 (en) * 1999-09-29 2001-12-18 Becton Dickinson And Company Process of making a molded device
ES2248165T3 (en) * 1999-11-15 2006-03-16 Velcro Industries B.V. SKIN FIXING ELEMENT.
US6406638B1 (en) 2000-01-06 2002-06-18 The Regents Of The University Of California Method of forming vertical, hollow needles within a semiconductor substrate, and needles formed thereby
US6558361B1 (en) 2000-03-09 2003-05-06 Nanopass Ltd. Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems
US6607673B2 (en) * 2000-05-17 2003-08-19 The University Of Tokyo Method for manufacturing a diamond cylinder array having dents therein
JP3385364B2 (en) * 2000-05-17 2003-03-10 東京大学長 Method for manufacturing diamond cylinder array having concave portion
US6595947B1 (en) 2000-05-22 2003-07-22 Becton, Dickinson And Company Topical delivery of vaccines
US6565532B1 (en) 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
US9717451B2 (en) * 2000-06-08 2017-08-01 Becton, Dickinson And Company Device for withdrawing or administering a substance and method of manufacturing a device
US6607513B1 (en) * 2000-06-08 2003-08-19 Becton, Dickinson And Company Device for withdrawing or administering a substance and method of manufacturing a device
US6540675B2 (en) * 2000-06-27 2003-04-01 Rosedale Medical, Inc. Analyte monitor
USRE44145E1 (en) 2000-07-07 2013-04-09 A.V. Topchiev Institute Of Petrochemical Synthesis Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties
US6603987B2 (en) * 2000-07-11 2003-08-05 Bayer Corporation Hollow microneedle patch
WO2002015960A2 (en) * 2000-08-21 2002-02-28 The Cleveland Clinic Foundation Microneedle array module and method of fabricating the same
US6533949B1 (en) * 2000-08-28 2003-03-18 Nanopass Ltd. Microneedle structure and production method therefor
US7108681B2 (en) 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
US7131987B2 (en) * 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
US7828827B2 (en) * 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US7211209B2 (en) * 2000-11-08 2007-05-01 Surface Logix, Inc. Method of making device for arraying biomolecules and for monitoring cell motility in real-time
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
US6611308B2 (en) * 2000-11-30 2003-08-26 Hannstar Display Corp. Cone protrusion in multi-domain vertically aligned liquid crystal display
US7144495B2 (en) 2000-12-13 2006-12-05 Lifescan, Inc. Electrochemical test strip with an integrated micro-needle and associated methods
WO2002064193A2 (en) 2000-12-14 2002-08-22 Georgia Tech Research Corporation Microneedle devices and production thereof
US6599322B1 (en) 2001-01-25 2003-07-29 Tecomet, Inc. Method for producing undercut micro recesses in a surface, a surgical implant made thereby, and method for fixing an implant to bone
US7018418B2 (en) 2001-01-25 2006-03-28 Tecomet, Inc. Textured surface having undercut micro recesses in a surface
US6620332B2 (en) 2001-01-25 2003-09-16 Tecomet, Inc. Method for making a mesh-and-plate surgical implant
US6663820B2 (en) 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
JP2004529906A (en) 2001-03-19 2004-09-30 イオマイ コーポレイシヨン Percutaneous immunostimulation
CN100349632C (en) * 2001-04-20 2007-11-21 阿尔扎公司 Microprojection array having beneficial agent contg coating
US20020195417A1 (en) * 2001-04-20 2002-12-26 Steinberg Dan A. Wet and dry etching process on <110> silicon and resulting structures
US8728445B2 (en) 2001-05-01 2014-05-20 A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Sciences Hydrogel Compositions
US8541021B2 (en) 2001-05-01 2013-09-24 A.V. Topchiev Institute Of Petrochemical Synthesis Hydrogel compositions demonstrating phase separation on contact with aqueous media
DE60239528D1 (en) 2001-05-01 2011-05-05 Corium International Redwood City TWO-PHASE, WATER-ABSORBING BIOADHESIVE COMPOSITION
US8206738B2 (en) 2001-05-01 2012-06-26 Corium International, Inc. Hydrogel compositions with an erodible backing member
US20050113510A1 (en) 2001-05-01 2005-05-26 Feldstein Mikhail M. Method of preparing polymeric adhesive compositions utilizing the mechanism of interaction between the polymer components
US8840918B2 (en) 2001-05-01 2014-09-23 A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences Hydrogel compositions for tooth whitening
US20050215727A1 (en) 2001-05-01 2005-09-29 Corium Water-absorbent adhesive compositions and associated methods of manufacture and use
US6591124B2 (en) 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
US6840910B2 (en) 2001-08-01 2005-01-11 Johnson & Johnson Consumer Companies, Inc. Method of distributing skin care products
US6790179B2 (en) 2001-08-01 2004-09-14 Johnson & Johnson Consumer Companies, Inc. Method of examining and diagnosing skin health
US6855117B2 (en) 2001-08-01 2005-02-15 Johnson & Johnson Consumer Companies, Inc. Method of treating the skin of a subject
AU2002312380A1 (en) * 2001-06-08 2002-12-23 Becton, Dickinson And Company Device for manipulating a needle or abrader array
US20020188310A1 (en) * 2001-06-08 2002-12-12 Seward Kirk Partick Microfabricated surgical device
US7127284B2 (en) * 2001-06-11 2006-10-24 Mercator Medsystems, Inc. Electroporation microneedle and methods for its use
US7682318B2 (en) 2001-06-12 2010-03-23 Pelikan Technologies, Inc. Blood sampling apparatus and method
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
ATE497731T1 (en) 2001-06-12 2011-02-15 Pelikan Technologies Inc DEVICE FOR INCREASING THE SUCCESS RATE OF BLOOD YIELD OBTAINED BY A FINGER PICK
US7025774B2 (en) 2001-06-12 2006-04-11 Pelikan Technologies, Inc. Tissue penetration device
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
EP1404235A4 (en) 2001-06-12 2008-08-20 Pelikan Technologies Inc Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
JP4149911B2 (en) 2001-06-12 2008-09-17 ペリカン テクノロジーズ インコーポレイテッド Electric lancet actuator
EP1404233B1 (en) 2001-06-12 2009-12-02 Pelikan Technologies Inc. Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties
US6767341B2 (en) * 2001-06-13 2004-07-27 Abbott Laboratories Microneedles for minimally invasive drug delivery
US7041257B2 (en) * 2001-09-25 2006-05-09 Cytonome, Inc. Microfabricated two-pin liquid sample dispensing system
US6686299B2 (en) * 2001-06-21 2004-02-03 Carlo D. Montemagno Nanosyringe array and method
US6749792B2 (en) * 2001-07-09 2004-06-15 Lifescan, Inc. Micro-needles and methods of manufacture and use thereof
US20030028087A1 (en) * 2001-08-01 2003-02-06 Yuzhakov Vadim Vladimirovich Devices for analyte concentration determination and methods of using the same
US6881203B2 (en) 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
US7286864B1 (en) 2001-09-07 2007-10-23 Orbital Research, Inc. Dry physiological recording device
US6785569B2 (en) 2001-09-07 2004-08-31 Orbital Research Dry physiological recording electrode
US8201330B1 (en) * 2001-09-07 2012-06-19 Orbital Research Inc Physiological recording device or electrode
US6782283B2 (en) * 2001-09-07 2004-08-24 Robert N. Schmidt Dry penetrating recording device
JP4383168B2 (en) * 2001-09-12 2009-12-16 ベクトン・ディキンソン・アンド・カンパニー Microneedle administration device and drug administration device
US20040087992A1 (en) * 2002-08-09 2004-05-06 Vladimir Gartstein Microstructures for delivering a composition cutaneously to skin using rotatable structures
US8361037B2 (en) * 2001-09-19 2013-01-29 Valeritas, Inc. Microneedles, microneedle arrays, and systems and methods relating to same
WO2003024508A2 (en) * 2001-09-21 2003-03-27 Biovalve Technologies, Inc. Gas pressure actuated microneedle arrays, and systems and methods relating to same
CA2500452A1 (en) * 2001-09-28 2003-04-03 Biovalve Technologies, Inc. Switchable microneedle arrays and systems and methods relating to same
US20030135201A1 (en) * 2001-09-28 2003-07-17 Gonnelli Robert R. Microneedle with membrane
WO2003051284A2 (en) * 2001-10-29 2003-06-26 Becton, Dickinson And Company Method and device for the delivery of a substance
US20040120964A1 (en) * 2001-10-29 2004-06-24 Mikszta John A. Needleless vaccination using chimeric yellow fever vaccine-vectored vaccines against heterologous flaviviruses
US7258839B2 (en) * 2001-12-21 2007-08-21 Cytonome, Inc. Temperature controlled microfabricated two-pin liquid sample dispensing system
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
US7051426B2 (en) * 2002-01-31 2006-05-30 Hewlett-Packard Development Company, L.P. Method making a cutting disk into of a substrate
US20030140496A1 (en) * 2002-01-31 2003-07-31 Shen Buswell Methods and systems for forming slots in a semiconductor substrate
US6911155B2 (en) * 2002-01-31 2005-06-28 Hewlett-Packard Development Company, L.P. Methods and systems for forming slots in a substrate
US20040060902A1 (en) * 2002-02-05 2004-04-01 Evans John D. Microprotrusion array and methods of making a microprotrusion
US7004928B2 (en) 2002-02-08 2006-02-28 Rosedale Medical, Inc. Autonomous, ambulatory analyte monitor or drug delivery device
US7105103B2 (en) * 2002-03-11 2006-09-12 Becton, Dickinson And Company System and method for the manufacture of surgical blades
US8116860B2 (en) 2002-03-11 2012-02-14 Altea Therapeutics Corporation Transdermal porator and patch system and method for using same
AU2003220143A1 (en) * 2002-03-11 2003-09-29 Altea Therapeutics Corporation Transdermal integrated actuator device, methods of making and using same
US9918665B2 (en) 2002-03-11 2018-03-20 Nitto Denko Corporation Transdermal porator and patch system and method for using same
US7387742B2 (en) * 2002-03-11 2008-06-17 Becton, Dickinson And Company Silicon blades for surgical and non-surgical use
US6716754B2 (en) * 2002-03-12 2004-04-06 Micron Technology, Inc. Methods of forming patterns and molds for semiconductor constructions
US20030186405A1 (en) * 2002-04-01 2003-10-02 The Ohio State University Research Foundation Micro/nano-embossing process and useful applications thereof
WO2003084401A1 (en) * 2002-04-04 2003-10-16 Matsushita Electric Industrial Co., Ltd. Lancet device
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7371247B2 (en) 2002-04-19 2008-05-13 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7648468B2 (en) 2002-04-19 2010-01-19 Pelikon Technologies, Inc. Method and apparatus for penetrating tissue
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7226461B2 (en) 2002-04-19 2007-06-05 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with sterility barrier release
US7909778B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7717863B2 (en) 2002-04-19 2010-05-18 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8372016B2 (en) 2002-04-19 2013-02-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling and analyte sensing
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US8360992B2 (en) 2002-04-19 2013-01-29 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7291117B2 (en) 2002-04-19 2007-11-06 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7175642B2 (en) 2002-04-19 2007-02-13 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US7060192B2 (en) 2002-05-09 2006-06-13 Lifescan, Inc. Methods of fabricating physiological sample collection devices
US6945952B2 (en) 2002-06-25 2005-09-20 Theraject, Inc. Solid solution perforator for drug delivery and other applications
US6899838B2 (en) * 2002-07-12 2005-05-31 Becton, Dickinson And Company Method of forming a mold and molding a micro-device
MXPA05000597A (en) * 2002-07-19 2005-04-28 3M Innovative Properties Co Microneedle devices and microneedle delivery apparatus.
US7020508B2 (en) 2002-08-22 2006-03-28 Bodymedia, Inc. Apparatus for detecting human physiological and contextual information
CA2497154C (en) * 2002-08-29 2012-01-03 Becton, Dickinson And Company Substance delivery via a rotating microabrading surface
US6946362B2 (en) * 2002-09-06 2005-09-20 Hewlett-Packard Development Company, L.P. Method and apparatus for forming high surface area material films and membranes
AU2003275311A1 (en) * 2002-09-16 2004-04-30 Sung-Yun Kwon Solid micro-perforators and methods of use
US20040106904A1 (en) 2002-10-07 2004-06-03 Gonnelli Robert R. Microneedle array patch
CA2501732C (en) 2002-10-09 2013-07-30 Bodymedia, Inc. Method and apparatus for auto journaling of continuous or discrete body states utilizing physiological and/or contextual parameters
CA2444211C (en) * 2002-10-11 2013-11-19 Dermal Therapy (Barbados) Inc. Determination of biological conditions using impedance measurements
US6755984B2 (en) * 2002-10-24 2004-06-29 Hewlett-Packard Development Company, L.P. Micro-casted silicon carbide nano-imprinting stamp
US7045069B2 (en) 2002-11-14 2006-05-16 Gennady Ozeryansky Microfabrication method based on metal matrix composite technology
US6962772B2 (en) * 2002-12-27 2005-11-08 Industrial Technology Research Inst. Method for manufacturing 3-D high aspect-ratio microneedle array device
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
JP2006515758A (en) * 2003-01-10 2006-06-08 レビオ インコーポレーティッド Highly controllable electroporation and its applications
KR100563330B1 (en) * 2003-01-16 2006-03-22 포스트마이크로 주식회사 Method for manufacturing of polymer micro needle array with liga process
US6821450B2 (en) * 2003-01-21 2004-11-23 Hewlett-Packard Development Company, L.P. Substrate and method of forming substrate for fluid ejection device
SE524340C2 (en) * 2003-01-22 2004-07-27 Tour & Andersson Ab Ways to make a membrane and membrane made according to the method
KR100562498B1 (en) * 2003-02-12 2006-03-21 삼성전자주식회사 Pad conditioner of cmp equipment
US7578954B2 (en) 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
EP1602623B1 (en) * 2003-03-07 2011-08-17 Tosoh Corporation Method of moulding a microfluidic structure and mould
US20050155955A1 (en) * 2003-03-10 2005-07-21 Daskal Vadim M. Method for reducing glare and creating matte finish of controlled density on a silicon surface
US20090007436A1 (en) * 2003-03-10 2009-01-08 Daskal Vadim M Silicon blades for surgical and non-surgical use
CA2421832C (en) * 2003-03-13 2006-10-10 Bradley A. Saville Enhancement of enzyme activity by selective purification
US7052652B2 (en) 2003-03-24 2006-05-30 Rosedale Medical, Inc. Analyte concentration detection devices and methods
US20040187661A1 (en) * 2003-03-25 2004-09-30 Obrachta Kevin L. Low penetration-force pinmat for perforating an uncured laminate sheet
US7347961B2 (en) 2003-04-01 2008-03-25 The Boeing Company Method and system having a flowable pressure pad for consolidating an uncured laminate sheet in a cure process
US20040195716A1 (en) * 2003-04-01 2004-10-07 Bergmann Blaise F. Method and system for utilizing low pressure for perforating and consolidating an uncured laminate sheet in one cycle of operation
US7415299B2 (en) * 2003-04-18 2008-08-19 The Regents Of The University Of California Monitoring method and/or apparatus
US20060025717A1 (en) * 2003-04-18 2006-02-02 The Regents Of The University Of California Method for forming hollow out-of-plane microneedles and devices formed hereby
ES2347248T3 (en) 2003-05-30 2010-10-27 Pelikan Technologies Inc. PROCEDURE AND APPLIANCE FOR FLUID INJECTION.
US7572405B2 (en) * 2003-06-02 2009-08-11 Corium International Inc. Method for manufacturing microstructures having hollow microelements using fluidic jets during a molding operation
US7850621B2 (en) 2003-06-06 2010-12-14 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
JP2005021678A (en) * 2003-06-10 2005-01-27 Medorekkusu:Kk Pad base for percutaneous admistration and its manufacturing method
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
FR2857282B1 (en) * 2003-07-11 2006-08-18 Oreal DEVICE FOR APPLYING A PRODUCT AND ASSEMBLY FOR PACKAGING AND APPLYING A PRODUCT
US7708544B2 (en) * 2003-07-21 2010-05-04 10X Technology Llc Apparatus and method for manufacturing microneedles
US20050036004A1 (en) * 2003-08-13 2005-02-17 Barbara Horn Methods and systems for conditioning slotted substrates
WO2005020912A2 (en) 2003-08-25 2005-03-10 3M Innovative Properties Company Delivery of immune response modifier compounds
JP2007514457A (en) 2003-09-17 2007-06-07 ベクトン・ディキンソン・アンド・カンパニー System and method for creating straight and non-linear grooves using routers in silicon and other crystalline materials
EP1671096A4 (en) 2003-09-29 2009-09-16 Pelikan Technologies Inc Method and apparatus for an improved sample capture device
WO2005037095A1 (en) 2003-10-14 2005-04-28 Pelikan Technologies, Inc. Method and apparatus for a variable user interface
US8016811B2 (en) * 2003-10-24 2011-09-13 Altea Therapeutics Corporation Method for transdermal delivery of permeant substances
WO2005044364A1 (en) * 2003-11-10 2005-05-19 Agency For Science, Technology And Research Microneedles and microneedle fabrication
EP1694400A1 (en) * 2003-11-28 2006-08-30 Acrux DDS Pty Ltd Method and system for rapid transdermal administration
US8871224B2 (en) 2003-12-09 2014-10-28 Allergan, Inc. Botulinum toxin therapy for skin disorders
US8017145B2 (en) * 2003-12-22 2011-09-13 Conopco, Inc. Exfoliating personal care wipe article containing an array of projections
CN100355470C (en) * 2003-12-26 2007-12-19 中国科学院理化技术研究所 Minisize solid silicon needle array chip and its preparation method and use
US8668656B2 (en) 2003-12-31 2014-03-11 Sanofi-Aventis Deutschland Gmbh Method and apparatus for improving fluidic flow and sample capture
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
US7241394B2 (en) * 2004-01-21 2007-07-10 Lumera Corporation Process of fabricating polymer sustained microelectrodes
AU2005210637B2 (en) 2004-01-30 2010-09-16 A.V. Topchiev Institute Of Petrochemical Synthesis Rapidly dissolving film for delivery of an active agent
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
US8551391B2 (en) * 2004-02-17 2013-10-08 Avery Dennison Corporation Method of making microneedles
US20070191761A1 (en) * 2004-02-23 2007-08-16 3M Innovative Properties Company Method of molding for microneedle arrays
WO2005087305A1 (en) * 2004-03-12 2005-09-22 Agency For Science, Technology And Research Methods and moulds for use in fabricating side-ported microneedles
US20050203575A1 (en) * 2004-03-15 2005-09-15 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Skin microactivation system and method
WO2005094526A2 (en) 2004-03-24 2005-10-13 Corium International, Inc. Transdermal delivery device
JP5065005B2 (en) 2004-04-01 2012-10-31 ザ ジェネラル ホスピタル コーポレイション Method and apparatus for dermatological treatment and tissue remodeling
US20050220734A1 (en) * 2004-04-02 2005-10-06 Allergan, Inc. Therapy for melanin related afflictions
US7909776B2 (en) * 2004-04-30 2011-03-22 Roche Diagnostics Operations, Inc. Lancets for bodily fluid sampling supplied on a tape
US8591436B2 (en) * 2004-04-30 2013-11-26 Roche Diagnostics Operations, Inc. Lancets for bodily fluid sampling supplied on a tape
US7396484B2 (en) * 2004-04-30 2008-07-08 Becton, Dickinson And Company Methods of fabricating complex blade geometries from silicon wafers and strengthening blade geometries
US7591806B2 (en) * 2004-05-18 2009-09-22 Bai Xu High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
EP1751546A2 (en) 2004-05-20 2007-02-14 Albatros Technologies GmbH &amp; Co. KG Printable hydrogel for biosensors
US7315758B2 (en) * 2004-06-03 2008-01-01 Lynntech, Inc. Transdermal delivery of therapeutic agent
US9775553B2 (en) 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
WO2005120365A1 (en) 2004-06-03 2005-12-22 Pelikan Technologies, Inc. Method and apparatus for a fluid sampling device
ES2650188T3 (en) * 2004-06-10 2018-01-17 3M Innovative Properties Company Device and patch application kit
EP1616551A1 (en) 2004-07-13 2006-01-18 L'oreal Cosmetic treatment for preventing or delaying the signs of skin ageing
CA2575675A1 (en) 2004-07-30 2006-03-09 Adeza Biomedical Corporation Oncofetal fibronectin as a marker for disease and other conditions and methods for detection of oncofetal fibronectin
KR20070048229A (en) 2004-08-05 2007-05-08 코리움 인터네셔널, 인크. Adhesive composition
US7560036B2 (en) * 2004-08-05 2009-07-14 Apogee Technology, Inc. System and method for drug delivery and microfluidic applications using microneedles
EP2289646B1 (en) * 2004-08-16 2014-02-12 Functional Microstructures Limited Device to be applied to a biological barrier
US20060058602A1 (en) * 2004-08-17 2006-03-16 Kwiatkowski Krzysztof C Interstitial fluid analyzer
US7316665B2 (en) * 2004-08-25 2008-01-08 Becton, Dickinson And Company Method and device for the delivery of a substance including a covering
SE0402100D0 (en) * 2004-08-30 2004-08-30 Bonsens Ab Molded micro-needles
US7132054B1 (en) * 2004-09-08 2006-11-07 Sandia Corporation Method to fabricate hollow microneedle arrays
US20060073208A1 (en) * 2004-10-01 2006-04-06 Allergan, Inc. Cosmetic neurotoxin compositions and methods
WO2006052765A2 (en) 2004-11-04 2006-05-18 Smith & Nephew, Inc. Cycle and load measurement device
EP1819379B1 (en) * 2004-11-18 2016-08-31 Nanopass Technologies Ltd. System for delivering fluid into flexible biological barrier
AU2005306426B2 (en) * 2004-11-18 2011-04-28 3M Innovative Properties Company Masking method for coating a microneedle array
WO2006055795A1 (en) * 2004-11-18 2006-05-26 3M Innovative Properties Company Low-profile microneedle array applicator
EP2388078B1 (en) 2004-11-18 2013-03-20 3M Innovative Properties Co. Method of contact coating a microneedle array
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
US20080307849A1 (en) * 2004-11-26 2008-12-18 Agency For Science, Technology And Research Method And Apparatus For Forming Microstructures
CN100528091C (en) * 2004-11-30 2009-08-19 苏州纳生微电子有限公司 Cosmetic skin needle, its manufacturing method and use
US20080009801A1 (en) * 2004-12-02 2008-01-10 Nickel Janice H Method for dispensing material into a drug delivery device
ATE468961T1 (en) 2004-12-07 2010-06-15 3M Innovative Properties Co METHOD FOR SHAPING A MICRONEEDLE
US20060147423A1 (en) * 2004-12-07 2006-07-06 Jean-Yves Legendre Transungual device
FR2878745B1 (en) 2004-12-07 2007-03-09 Oreal TRANSUNGEAL DEVICE
ES2354081T3 (en) * 2004-12-10 2011-03-09 3M Innovative Properties Company MEDICAL DEVICE.
CN100408126C (en) * 2004-12-13 2008-08-06 纳生微电子(苏州)有限公司 Preparing method for epidermis needle and its application
US7588705B2 (en) * 2004-12-28 2009-09-15 Nabtesco Corporation Skin needle manufacturing apparatus and skin needle manufacturing method
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
JP4793806B2 (en) 2005-03-22 2011-10-12 Ｔｔｉ・エルビュー株式会社 Iontophoresis device
EP1885210A1 (en) * 2005-03-23 2008-02-13 Velcro Industries B.V. Molding touch fastener elements
WO2006105146A2 (en) * 2005-03-29 2006-10-05 Arkal Medical, Inc. Devices, systems, methods and tools for continuous glucose monitoring
US7601284B2 (en) * 2005-04-06 2009-10-13 Velcro Industries B.V. Molding fastener elements on folded substrate
JP5301985B2 (en) 2005-04-07 2013-09-25 スリーエム イノベイティブ プロパティズ カンパニー System and method for tool feedback sensing
CA2612866A1 (en) * 2005-05-11 2006-11-23 Corium International, Inc. Permeabilization of biological membranes
JP5020080B2 (en) * 2005-05-13 2012-09-05 久光製薬株式会社 Manufacturing method of medical equipment
US7442029B2 (en) * 2005-05-16 2008-10-28 Asml Netherlands B.V. Imprint lithography
US8048017B2 (en) * 2005-05-18 2011-11-01 Bai Xu High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
US8043250B2 (en) * 2005-05-18 2011-10-25 Nanomed Devices, Inc. High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
SG128494A1 (en) * 2005-06-09 2007-01-30 Nanyang Polytechnic Polymeric microneedle array and apparatus and method for manufacturing of the same
US20060281187A1 (en) 2005-06-13 2006-12-14 Rosedale Medical, Inc. Analyte detection devices and methods with hematocrit/volume correction and feedback control
JP4959151B2 (en) * 2005-06-14 2012-06-20 ナブテスコ株式会社 Method and apparatus for manufacturing skin needle
US20060283465A1 (en) * 2005-06-16 2006-12-21 Nickel Janice H Smart drug delivery system and a method of implementation thereof
CA2612005C (en) 2005-06-17 2013-10-29 Georgia Tech Research Corporation Coated microstructures and method of manufacture thereof
US20080195035A1 (en) 2005-06-24 2008-08-14 Frederickson Franklyn L Collapsible Patch and Method of Application
WO2007002522A1 (en) 2005-06-27 2007-01-04 3M Innovative Properties Company Microneedle cartridge assembly and method of applying
EP2474338B1 (en) 2005-06-27 2013-07-24 3M Innovative Properties Company Microneedle array applicator device
JP2007014588A (en) * 2005-07-08 2007-01-25 Nano Device & System Research Inc Percutaneous administration apparatus, and mold for manufacturing percutaneous administration apparatus
CN101227940A (en) * 2005-07-25 2008-07-23 纳米技术维多利亚有限公司 Microarray device
JP5000866B2 (en) * 2005-08-01 2012-08-15 久光製薬株式会社 Non-toxic biopharmaceutical transport equipment
US20070078414A1 (en) * 2005-08-05 2007-04-05 Mcallister Devin V Methods and devices for delivering agents across biological barriers
CN103637840A (en) 2005-08-23 2014-03-19 史密夫和内修有限公司 Telemetric orthopaedic implant
JP4519037B2 (en) * 2005-08-31 2010-08-04 東京エレクトロン株式会社 Heating device and coating / developing device
DK1940459T3 (en) * 2005-09-06 2014-05-26 Theraject Inc SOLID SOLUTION PERFORATOR CONTAINING ACTIVE SUBSTANCE PARTICLES AND / OR ACTIVE SUBSTANCED PARTICLES
US9486274B2 (en) 2005-09-07 2016-11-08 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US10548659B2 (en) 2006-01-17 2020-02-04 Ulthera, Inc. High pressure pre-burst for improved fluid delivery
US9011473B2 (en) 2005-09-07 2015-04-21 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US8518069B2 (en) 2005-09-07 2013-08-27 Cabochon Aesthetics, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9358033B2 (en) * 2005-09-07 2016-06-07 Ulthera, Inc. Fluid-jet dissection system and method for reducing the appearance of cellulite
RU2008114490A (en) 2005-09-15 2009-10-20 ТиТиАй ЭЛЛЕБО, ИНК. (JP) STEM TYPE IONTOPHORESIS DEVICE
US20070185432A1 (en) * 2005-09-19 2007-08-09 Transport Pharmaceuticals, Inc. Electrokinetic system and method for delivering methotrexate
US20070066934A1 (en) * 2005-09-19 2007-03-22 Transport Pharmaceuticals, Inc. Electrokinetic delivery system and methods therefor
US20070073212A1 (en) * 2005-09-28 2007-03-29 Takehiko Matsumura Iontophoresis apparatus and method to deliver active agents to biological interfaces
US20070093789A1 (en) * 2005-09-30 2007-04-26 Transcutaneous Technologies Inc. Iontophoresis apparatus and method for delivery of angiogenic factors to enhance healing of injured tissue
WO2007041244A2 (en) 2005-09-30 2007-04-12 Intuity Medical, Inc. Multi-site body fluid sampling and analysis cartridge
US7574256B2 (en) 2005-09-30 2009-08-11 Tti Ellebeau, Inc. Iontophoretic device and method of delivery of active agents to biological interface
US8801631B2 (en) 2005-09-30 2014-08-12 Intuity Medical, Inc. Devices and methods for facilitating fluid transport
WO2007061781A1 (en) * 2005-11-18 2007-05-31 3M Innovative Properties Company Coatable compositions, coatings derived therefrom and microarrays having such coatings
US20080262416A1 (en) * 2005-11-18 2008-10-23 Duan Daniel C Microneedle Arrays and Methods of Preparing Same
US7842008B2 (en) 2005-11-21 2010-11-30 Becton, Dickinson And Company Intradermal delivery device
US7885793B2 (en) 2007-05-22 2011-02-08 International Business Machines Corporation Method and system for developing a conceptual model to facilitate generating a business-aligned information technology solution
US20070151920A1 (en) * 2005-12-06 2007-07-05 Kay Ronald J System and method of micromolded filtration microstructure and devices
US7651946B2 (en) * 2005-12-12 2010-01-26 University College Cork - National University Of Ireland, Cork Wet etch processing
US9636035B2 (en) * 2005-12-14 2017-05-02 Scibase Ab Medical apparatus for determination of biological conditions using impedance measurements
EP1962942A1 (en) * 2005-12-21 2008-09-03 3M Innovative Properties Company Microneedle devices
EP1968777B1 (en) * 2005-12-23 2013-11-06 3M Innovative Properties Company Manufacturing microneedle arrays
JP2009522011A (en) 2005-12-30 2009-06-11 Ｔｔｉ・エルビュー株式会社 Iontophoresis system, apparatus and method for delivering an active substance to a biological interface
US7658728B2 (en) 2006-01-10 2010-02-09 Yuzhakov Vadim V Microneedle array, patch, and applicator for transdermal drug delivery
US9339641B2 (en) 2006-01-17 2016-05-17 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
US9610459B2 (en) 2009-07-24 2017-04-04 Emkinetics, Inc. Cooling systems and methods for conductive coils
EP1820441A1 (en) * 2006-02-16 2007-08-22 Roche Diagnostics GmbH Microneedle arrays with attenuated total reflection (ATR) sensor
WO2007112309A2 (en) * 2006-03-24 2007-10-04 3M Innovative Properties Company Process for making microneedles, microneedle arrays, masters, and replication tools
US20080154107A1 (en) * 2006-12-20 2008-06-26 Jina Arvind N Device, systems, methods and tools for continuous glucose monitoring
US20090131778A1 (en) * 2006-03-28 2009-05-21 Jina Arvind N Devices, systems, methods and tools for continuous glucose monitoring
US20100049021A1 (en) * 2006-03-28 2010-02-25 Jina Arvind N Devices, systems, methods and tools for continuous analyte monitoring
US7491341B2 (en) * 2006-03-31 2009-02-17 Battelle Memorial Institute Method of making tapered capillary tips with constant inner diameters
US9119945B2 (en) 2006-04-20 2015-09-01 3M Innovative Properties Company Device for applying a microneedle array
CN101074935B (en) * 2006-05-19 2011-03-23 清华大学 Detector array and its apparatus
US20070276318A1 (en) * 2006-05-26 2007-11-29 Mit, Llp Iontosonic-microneedle applicator apparatus and methods
US20070276330A1 (en) * 2006-05-28 2007-11-29 Beck Patricia A Microneedles and methods of fabricating thereof
US20070282246A1 (en) * 2006-06-05 2007-12-06 Mit, Llp Iontosonic-microneedle biosensor apparatus and methods
EP2047882B1 (en) 2006-07-27 2014-09-10 Toppan Printing Co., Ltd. Microneedle and method for producing microneedle
DE102006036331A1 (en) 2006-08-03 2008-02-14 Stephan Hammelbacher Device and method for marking objects
US20080058726A1 (en) * 2006-08-30 2008-03-06 Arvind Jina Methods and Apparatus Incorporating a Surface Penetration Device
US9005102B2 (en) 2006-10-02 2015-04-14 Emkinetics, Inc. Method and apparatus for electrical stimulation therapy
US10786669B2 (en) 2006-10-02 2020-09-29 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
US11224742B2 (en) 2006-10-02 2022-01-18 Emkinetics, Inc. Methods and devices for performing electrical stimulation to treat various conditions
EP2069013A2 (en) 2006-10-02 2009-06-17 Emkinetics, Inc. Method and apparatus for magnetic induction therapy
EP2090331A4 (en) * 2006-11-22 2012-04-18 Toppan Printing Co Ltd Microneedle array and process for production thereof
US7785301B2 (en) * 2006-11-28 2010-08-31 Vadim V Yuzhakov Tissue conforming microneedle array and patch for transdermal drug delivery or biological fluid collection
EP2061551A2 (en) * 2006-12-01 2009-05-27 TTI ellebeau, Inc. Systems, devices, and methods for powering and/or controlling devices, for instance transdermal delivery devices
CN100460028C (en) * 2006-12-08 2009-02-11 中国科学院上海微系统与信息技术研究所 Miniature needle array for medicine transmission and its making process
FR2909552B1 (en) 2006-12-12 2009-11-20 Oreal COSMETIC USE OF ANISIC ACID TO PROMOTE DESQUACATION
US10525246B2 (en) 2006-12-22 2020-01-07 Nanomed Skincare, Inc. Microdevice and method for transdermal delivery and sampling of active substances
US20080214987A1 (en) * 2006-12-22 2008-09-04 Nanomed Devices, Inc. Microdevice And Method For Transdermal Delivery And Sampling Of Active Substances
CA2676221C (en) 2007-01-22 2016-12-20 Corium International, Inc. Applicators for microneedles
WO2008103181A1 (en) 2007-02-23 2008-08-28 Smith & Nephew, Inc. Processing sensed accelerometer data for determination of bone healing
US8560059B2 (en) * 2007-03-09 2013-10-15 Covidien Lp System and methods for optical sensing and drug delivery using microneedles
US7713196B2 (en) * 2007-03-09 2010-05-11 Nellcor Puritan Bennett Llc Method for evaluating skin hydration and fluid compartmentalization
US20080234562A1 (en) * 2007-03-19 2008-09-25 Jina Arvind N Continuous analyte monitor with multi-point self-calibration
US20080251655A1 (en) * 2007-04-12 2008-10-16 Housley Todd B Bottle Holder
EP2146689B1 (en) 2007-04-16 2020-08-12 Corium, Inc. Solvent-cast microneedle arrays containing active
US20080312518A1 (en) * 2007-06-14 2008-12-18 Arkal Medical, Inc On-demand analyte monitor and method of use
US20100121307A1 (en) * 2007-08-24 2010-05-13 Microfabrica Inc. Microneedles, Microneedle Arrays, Methods for Making, and Transdermal and/or Intradermal Applications
JP4381438B2 (en) * 2007-09-05 2009-12-09 渡 渡邉 Drug sheet
JP6121088B2 (en) 2007-09-06 2017-04-26 スミス アンド ネフュー インコーポレイテッド System and method for communicating with a telemetric implant
CN101808588B (en) * 2007-09-28 2012-12-19 贝尔法斯特女王大学 Delivery device and method
US8439940B2 (en) 2010-12-22 2013-05-14 Cabochon Aesthetics, Inc. Dissection handpiece with aspiration means for reducing the appearance of cellulite
WO2009048607A1 (en) 2007-10-10 2009-04-16 Corium International, Inc. Vaccine delivery via microneedle arrays
US20090099427A1 (en) * 2007-10-12 2009-04-16 Arkal Medical, Inc. Microneedle array with diverse needle configurations
WO2009064380A2 (en) 2007-11-09 2009-05-22 California Institute Of Technology Fabrication of anchored carbon nanotube array devices for integrated light collection and energy conversion
AU2008341030B2 (en) 2007-12-24 2014-04-17 Vaxxas Pty Limited Coating method
CA2749347C (en) 2008-02-07 2018-03-27 The University Of Queensland Patch production
GB0802447D0 (en) * 2008-02-09 2008-03-19 Univ Manchester Fluid extraction device, associated materials and methods
US8425596B2 (en) * 2008-03-21 2013-04-23 Ut-Battelle, Llc Retinal instrument
WO2009124095A1 (en) * 2008-03-31 2009-10-08 Abbott Diabetes Care Inc. Shallow implantable analyte sensor with rapid physiological response
WO2009126900A1 (en) 2008-04-11 2009-10-15 Pelikan Technologies, Inc. Method and apparatus for analyte detecting device
JP2011519635A (en) * 2008-05-02 2011-07-14 エスアールアイ インターナショナル Optical microneedle spectrometer
AU2009249610B2 (en) * 2008-05-21 2014-01-16 Theraject, Inc. Method of manufacturing solid solution perforator patches and uses thereof
US9387000B2 (en) 2008-05-23 2016-07-12 The University Of Queensland Analyte detection using a needle projection patch
JP5816080B2 (en) 2008-05-30 2015-11-17 インテュイティ メディカル インコーポレイテッド Body fluid collection device and collection site interface
CA2726067C (en) 2008-06-06 2020-10-20 Intuity Medical, Inc. Detection meter and mode of operation
JP2011522594A (en) 2008-06-06 2011-08-04 インテュイティ メディカル インコーポレイテッド Medical diagnostic apparatus and method
RU2545424C2 (en) 2008-10-15 2015-03-27 Смит Энд Нефью, Инк. Composite inner retainer
WO2010059861A1 (en) * 2008-11-20 2010-05-27 University Of Southern California Compositions and methods to modulate hair growth
WO2010065067A1 (en) 2008-11-20 2010-06-10 Bodymedia, Inc. Method and apparatus for determining critical care parameters
EP2375973A4 (en) 2008-12-16 2014-02-12 Bodymedia Inc Method and apparatus for determining heart rate variability using wavelet transformation
CA2751884C (en) 2009-01-14 2018-09-25 Corium International, Inc. Transdermal administration of tamsulosin
WO2010087971A2 (en) 2009-01-27 2010-08-05 California Institute Of Technology Drug delivery and substance transfer facilitated by nano-enhanced device having aligned carbon nanotubes protruding from device surface
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
CN101856538B (en) * 2009-04-09 2012-06-20 香港理工大学 Microneedles array, die casting method for manufacturing microneedle array and die for manufacturing microneedle array
JP2012523270A (en) 2009-04-10 2012-10-04 スリーエム イノベイティブ プロパティズ カンパニー Method for producing hollow microneedle array, product derived therefrom and use thereof
FI20095433A0 (en) * 2009-04-20 2009-04-20 Valtion Teknillinen micro-needle
US8399443B2 (en) 2009-04-22 2013-03-19 Mercator Medsystems, Inc. Treatment of hypertension by renal vascular delivery of guanethidine
WO2010124255A2 (en) 2009-04-24 2010-10-28 Corium International, Inc. Methods for manufacturing microprojection arrays
US11096708B2 (en) 2009-08-07 2021-08-24 Ulthera, Inc. Devices and methods for performing subcutaneous surgery
US9358064B2 (en) 2009-08-07 2016-06-07 Ulthera, Inc. Handpiece and methods for performing subcutaneous surgery
US8834423B2 (en) 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
JP2013508119A (en) 2009-10-26 2013-03-07 エムキネティクス， インコーポレイテッド Method and apparatus for electromagnetic stimulation of nerves, muscles and body tissues
US8919605B2 (en) 2009-11-30 2014-12-30 Intuity Medical, Inc. Calibration material delivery devices and methods
GB2478363A (en) * 2010-03-05 2011-09-07 Ndm Technologies Ltd Microneedle patch and method of manufacture
US9115424B2 (en) 2010-04-07 2015-08-25 California Institute Of Technology Simple method for producing superhydrophobic carbon nanotube array
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
MX336139B (en) 2010-04-28 2016-01-08 Kimberly Clark Co MEDICAL DEVICES FOR DELIVERY OF siRNA.
MX345837B (en) 2010-04-28 2017-02-16 Kimberly-Clark Worldwide Incorporated Device for delivery of rheumatoid arthritis medication.
AU2011246882B2 (en) 2010-04-28 2016-02-25 Sorrento Therapeutics, Inc. Nanopatterned medical device with enhanced cellular interaction
CA2796965C (en) 2010-04-28 2019-04-16 Kimberly-Clark Worldwide, Inc. Method for increasing permeability of an epithelial barrier
JP6327852B2 (en) 2010-05-04 2018-05-23 コリウム インターナショナル， インコーポレイテッド Methods and devices for transdermal delivery of parathyroid hormone using microprojection arrays
CN102971038B (en) 2010-05-04 2016-02-03 考里安国际公司 Micropin applicator
US8588884B2 (en) 2010-05-28 2013-11-19 Emkinetics, Inc. Microneedle electrode
CN101905856B (en) * 2010-06-11 2012-10-10 北京大学 Method for preparing plane hollow microneedle for transdermal administration
EP2584964B1 (en) 2010-06-25 2021-08-04 Intuity Medical, Inc. Analyte monitoring devices
WO2012006677A1 (en) 2010-07-14 2012-01-19 The University Of Queensland Patch applying apparatus
EP2633881A4 (en) * 2010-10-25 2014-02-19 Teijin Ltd Microneedle
US8609458B2 (en) 2010-12-10 2013-12-17 California Institute Of Technology Method for producing graphene oxide with tunable gap
WO2012100002A1 (en) * 2011-01-18 2012-07-26 Massachusetts Institute Of Technology Deployable barbed microneedle array and uses thereof
US8976507B2 (en) 2011-03-29 2015-03-10 California Institute Of Technology Method to increase the capacitance of electrochemical carbon nanotube capacitors by conformal deposition of nanoparticles
GB201107642D0 (en) 2011-05-09 2011-06-22 Univ Cork Method
US8636696B2 (en) 2011-06-10 2014-01-28 Kimberly-Clark Worldwide, Inc. Transdermal device containing microneedles
WO2013020103A1 (en) 2011-08-03 2013-02-07 Intuity Medical, Inc. Devices and methods for body fluid sampling and analysis
WO2013055638A1 (en) 2011-10-12 2013-04-18 3M Innovative Properties Company Integrated microneedle array delivery system
US11179553B2 (en) 2011-10-12 2021-11-23 Vaxxas Pty Limited Delivery device
AU2012325801B2 (en) 2011-10-19 2016-05-12 Mercator Medsystems, Inc. Localized modulation of tissues and cells to enhance therapeutic effects including renal denervation
JP5879927B2 (en) * 2011-10-26 2016-03-08 凸版印刷株式会社 Microneedle device and manufacturing method thereof
EP3574950B1 (en) 2011-10-27 2021-02-17 Sorrento Therapeutics, Inc. Transdermal delivery of high viscosity bioactive agents
US20170246439A9 (en) 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
JP2013111104A (en) * 2011-11-25 2013-06-10 Dainippon Printing Co Ltd Method for manufacturing microneedle device
WO2013090844A1 (en) 2011-12-14 2013-06-20 California Institute Of Technology Sharp tip carbon nanotube microneedle devices and their fabrication
EP2790684B1 (en) 2011-12-16 2016-10-12 3M Innovative Properties Company Foldable adhesive composite dressing
US9144671B2 (en) 2011-12-21 2015-09-29 3M Innovative Properties Company Transdermal adhesive patch assembly with removable microneedle array and method of using same
CN104053531B (en) * 2012-01-16 2017-05-03 皇家飞利浦有限公司 Engineered surface for providing low friction and improved comfort on devices that contact the skin or other external tissue of the user
JP6106922B2 (en) * 2012-02-24 2017-04-05 凸版印刷株式会社 Manufacturing method of fine nozzle
CN103301092B (en) 2012-03-06 2014-12-03 中国科学院理化技术研究所 Polymer micro-needle array chip, and preparation method and application thereof
US9245671B2 (en) * 2012-03-14 2016-01-26 Ut-Battelle, Llc Electrically isolated, high melting point, metal wire arrays and method of making same
CA2871770C (en) 2012-05-01 2020-07-07 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Tip-loaded microneedle arrays for transdermal insertion
AU2013280753A1 (en) * 2012-06-29 2015-01-22 Elc Management Llc Microneedles comprising one or more cosmetic ingredients
CN103568160B (en) * 2012-07-27 2015-11-04 中国科学院理化技术研究所 A kind of preparation method of polymer material micro-needle array patch
WO2014022314A1 (en) 2012-07-30 2014-02-06 California Institute Of Technology Nano tri-carbon composite systems and manufacture
US20200009364A1 (en) * 2012-09-13 2020-01-09 Avraham Amir Microneedles and compositions for skin augmentation
CN105073102B (en) 2012-10-01 2018-06-19 香港科技大学 Transdermal label apparatus
WO2014058746A1 (en) 2012-10-10 2014-04-17 3M Innovative Properties Company Force-controlled applicator for applying a microneedle device to skin
EP2906285B1 (en) 2012-10-10 2019-06-12 3M Innovative Properties Company Applicator for applying a microneedle device to skin
WO2014077244A1 (en) * 2012-11-13 2014-05-22 富士フイルム株式会社 Transdermal absorption sheet, and manufacturing method for same
EP2919849B1 (en) 2012-11-16 2021-01-06 Kindeva Drug Delivery L.P. Force-controlled applicator for applying a microneedle device to skin
WO2014076326A1 (en) * 2012-11-19 2014-05-22 Simplicity Works Europe, S.L. Tool for reproducing three-dimensional surfaces
MX2015008157A (en) 2012-12-21 2016-02-22 Corium Int Inc Microarray for delivery of therapeutic agent and methods of use.
KR102219636B1 (en) 2012-12-27 2021-02-23 쓰리엠 이노베이티브 프로퍼티즈 컴파니 Article with hollow microneedles and method of making
WO2014110016A1 (en) 2013-01-08 2014-07-17 3M Innovative Properties Company Applicator for applying a microneedle device to skin
US20150352777A1 (en) * 2013-01-18 2015-12-10 The University Of North Carolina At Chapel Hill High-throughput manufacturing of microneedles
ES2921481T3 (en) 2013-03-12 2022-08-26 Corium Inc Microprojection applicators
US9192313B1 (en) 2013-03-14 2015-11-24 Orbital Research Inc. Dry physiological recording device and method of manufacturing
US10820860B2 (en) 2013-03-14 2020-11-03 One Drop Biosensor Technologies, Llc On-body microsensor for biomonitoring
US9182368B2 (en) 2013-03-14 2015-11-10 Sano Intelligence, Inc. Method of manufacturing a sensor for sensing analytes
EP4059450A1 (en) 2013-03-15 2022-09-21 Corium, Inc. Microstructure array for delivery of active agents
EP2968118B1 (en) 2013-03-15 2022-02-09 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
CA2903763C (en) 2013-03-15 2021-11-16 Corium International, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
EP2968751B1 (en) 2013-03-15 2022-11-30 Corium, Inc. Multiple impact microprojection applicators
ES2761580T3 (en) * 2013-03-15 2020-05-20 Corium Inc Microarrays for therapeutic agent delivery, methods of use and manufacturing methods
KR101712413B1 (en) 2013-03-22 2017-03-06 쓰리엠 이노베이티브 프로퍼티즈 컴파니 Microneedle applicator comprising a counter assembly
DE102013005197A1 (en) 2013-03-25 2014-09-25 Michael Horstmann Swinging microneedle plaster
US10542922B2 (en) 2013-03-26 2020-01-28 The Trustees Of Columbia University In The City Of New York Fluid extraction and drug delivery system and methods using microneedles
ITTO20130284A1 (en) * 2013-04-09 2014-10-10 Fond Istituto Italiano Di Tecnologia PROCEDURE FOR THE PRODUCTION OF SHAPED POLYMERIC MICROPARTELS
US10245423B2 (en) 2013-05-06 2019-04-02 Juvic Inc. Method for manufacturing microstructure using centrifugal force and microstructure manufactured by same
US20140350518A1 (en) 2013-05-23 2014-11-27 Allergan, Inc. Syringe extrusion accessory
CN105263562B (en) 2013-05-31 2018-09-21 3M创新有限公司 Microneedle injection and infusion apparatus and its application method
CN105246541B (en) 2013-05-31 2018-01-16 3M创新有限公司 Microneedle injection equipment including double coverings
CN105283216B (en) 2013-05-31 2018-01-26 3M创新有限公司 Micropin injection device including being inverted actuator
CA2914539C (en) * 2013-06-13 2016-11-01 Microdermics Inc. Metallic microneedles
CA2912283A1 (en) 2013-06-21 2014-12-21 Intuity Medical, Inc. Analyte monitoring system with audible feedback
EP3021930B1 (en) 2013-07-16 2020-10-07 3M Innovative Properties Company Hollow microneedle with beveled tip
CN105407957A (en) 2013-07-16 2016-03-16 3M创新有限公司 Article comprising a microneedle
CN105407956B (en) 2013-07-16 2018-12-11 3M创新有限公司 Empty micropin with inclined-plane opening
EP3021931B1 (en) 2013-07-16 2021-09-01 Kindeva Drug Delivery L.P. Hollow microneedle array article
US20160193824A1 (en) * 2013-08-12 2016-07-07 Tufts University Micro forming devices and systems and uses thereof
WO2015038974A1 (en) 2013-09-13 2015-03-19 University Of Utah Research Foundation Micro-molded electrodes, arrays, and methods of making the same
US10029048B2 (en) 2014-05-13 2018-07-24 Allergan, Inc. High force injection devices
US10321858B2 (en) 2014-08-18 2019-06-18 Proteadx, Inc. Apparatus and methods for transdermal sensing of analytes in interstitial fluid and associated data transmission systems
EP3193828B8 (en) 2014-08-29 2023-04-05 Corium Pharma Solutions, Inc. Microstructure array for delivery of active agents
EP3188714A1 (en) 2014-09-04 2017-07-12 Corium International, Inc. Microstructure array, methods of making, and methods of use
US9933387B1 (en) 2014-09-07 2018-04-03 Biolinq, Inc. Miniaturized sub-nanoampere sensitivity low-noise potentiostat system
US10226585B2 (en) 2014-10-01 2019-03-12 Allergan, Inc. Devices for injection and dosing
CN107073249B (en) 2014-10-17 2021-01-01 花王株式会社 Method for producing fine hollow projections
JP6064012B1 (en) * 2014-10-17 2017-01-18 花王株式会社 Method for producing fine hollow projection
US10550187B2 (en) 2014-10-24 2020-02-04 Incept, Llc Extra luminal scaffold
JP6906885B2 (en) 2014-11-14 2021-07-21 ロレアル Microneedle sheet to reduce wrinkles
EP3247449B1 (en) 2015-01-21 2021-01-06 Kindeva Drug Delivery L.P. Microneedle array
CN107206066A (en) 2015-01-27 2017-09-26 3M创新有限公司 Aluminated coating agent for micropin vaccine patch
WO2016123665A1 (en) 2015-02-02 2016-08-11 Vaxxas Pty Limited Microprojection array applicator and method
CN107206220A (en) * 2015-02-16 2017-09-26 凸版印刷株式会社 Micropin
US20160256611A1 (en) * 2015-03-04 2016-09-08 Microvention, Inc. Drug Delivery Device
CN107530490B (en) 2015-03-10 2021-06-25 爱力根销售有限责任公司 Multi-needle syringe
US10441768B2 (en) 2015-03-18 2019-10-15 University of Pittsburgh—of the Commonwealth System of Higher Education Bioactive components conjugated to substrates of microneedle arrays
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
JP6646985B2 (en) * 2015-09-08 2020-02-14 花王株式会社 Manufacturing method of fine projection tool
TWI647171B (en) * 2015-09-08 2019-01-11 國立臺灣科技大學 Method for fabricating a micro-needle array
WO2017045031A1 (en) 2015-09-18 2017-03-23 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
US11684763B2 (en) 2015-10-16 2023-06-27 University of Pittsburgh—of the Commonwealth System of Higher Education Multi-component bio-active drug delivery and controlled release to the skin by microneedle array devices
US11744889B2 (en) 2016-01-05 2023-09-05 University of Pittsburgh—of the Commonwealth System of Higher Education Skin microenvironment targeted delivery for promoting immune and other responses
JP2017131397A (en) * 2016-01-27 2017-08-03 花王株式会社 Method of producing fine, and hollow projection tool
JP2019513070A (en) 2016-03-01 2019-05-23 キトテック メディカル， インコーポレイテッド Microstructure-based systems, devices and methods for wound closure
JP6717638B2 (en) * 2016-03-31 2020-07-01 花王株式会社 Method for manufacturing fine hollow protrusion having opening
JP6693790B2 (en) * 2016-03-31 2020-05-13 花王株式会社 Method for manufacturing fine hollow protrusion having opening
CN105771082A (en) * 2016-04-07 2016-07-20 南通纺织丝绸产业技术研究院 Blank pipe fibroin microneedle drug administration system and preparation method thereof
KR102288170B1 (en) 2016-04-08 2021-08-09 알레간 인코포레이티드 Aspiration and injection device
US10092207B1 (en) 2016-05-15 2018-10-09 Biolinq, Inc. Tissue-penetrating electrochemical sensor featuring a co-electrodeposited thin film comprised of polymer and bio-recognition element
KR102038751B1 (en) * 2016-11-18 2019-10-30 연세대학교 산학협력단 Microneddle array with complex formulation and method for manufacturing the same
US11235132B2 (en) * 2016-12-22 2022-02-01 Ohio State Innovation Foundation Interpenetrating microstructures for nanochannel-based cargo delivery
EP3372165A1 (en) * 2017-03-07 2018-09-12 Koninklijke Philips N.V. Enhanced sampling using applied energy
EP3600263B1 (en) * 2017-03-24 2024-01-03 E Ink Corporation Microcell systems for delivering active molecules
USD867582S1 (en) 2017-03-24 2019-11-19 Allergan, Inc. Syringe device
EP4306803A3 (en) 2017-03-31 2024-04-10 Vaxxas Pty Limited Device and method for coating surfaces
US11045142B1 (en) 2017-04-29 2021-06-29 Biolinq, Inc. Heterogeneous integration of silicon-fabricated solid microneedle sensors and CMOS circuitry
TWI629073B (en) * 2017-05-16 2018-07-11 怡定興科技股份有限公司 Microneedle patch manufacturing method
TWI633901B (en) * 2017-05-16 2018-09-01 怡定興科技股份有限公司 Medical beauty microneedle patch manufacturing method
KR102248950B1 (en) 2017-06-07 2021-05-06 카오카부시키가이샤 Manufacturing method of fine protrusion unit and fine protrusion unit
EP3639010A4 (en) 2017-06-13 2021-03-17 Vaxxas Pty Limited Quality control of substrate coatings
EP4218893A1 (en) 2017-08-04 2023-08-02 Vaxxas Pty Limited Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (map)
JP6965068B2 (en) * 2017-09-13 2021-11-10 花王株式会社 Hollow protrusion manufacturing method, hollow protrusion manufacturing equipment, and hollow protrusion
WO2019058328A1 (en) 2017-09-22 2019-03-28 Sabic Global Technologies B.V. Microneedle arrays
WO2019058329A1 (en) 2017-09-22 2019-03-28 Sabic Global Technologies B.V. Methods and systems of producing microneedle arrays
BR112020007566A2 (en) 2017-10-17 2020-09-24 3M Innovative Properties Company applicator to apply a microneedle matrix to the skin
US20210228119A1 (en) 2018-05-16 2021-07-29 Kindeva Drug Delivery L.P. Microneedle biosensor
USD875254S1 (en) 2018-06-08 2020-02-11 Biolinq, Inc. Intradermal biosensor
WO2020005973A1 (en) 2018-06-25 2020-01-02 Corium, Inc. Hybrid method of forming microstructure array molds, methods of making microstructure arrays, and methods of use
CN109173039B (en) * 2018-08-17 2021-03-16 安徽中鼎玉铉新材料科技有限公司 Preparation method of inverted funnel-shaped silicon-based solid microneedle array
EP3845266A4 (en) * 2018-08-28 2022-06-15 Industry-Academic Cooperation Foundation, Yonsei University Perforated plate microstructure module
US10940554B2 (en) 2018-11-30 2021-03-09 International Business Machines Corporation Planar fabrication of micro-needles
CN111298279B (en) * 2018-12-11 2024-01-26 尹忠 Preparation device and preparation method of drug administration microneedle
WO2022026764A1 (en) 2020-07-29 2022-02-03 Biolinq Inc. Continuous analyte monitoring system with microneedle array
CN112807561A (en) * 2021-01-26 2021-05-18 上海烨映微电子科技股份有限公司 Microneedle structure and method for producing same
USD988160S1 (en) 2021-03-16 2023-06-06 Biolinq Incorporated Wearable dermal sensor
EP4153276A4 (en) 2021-05-08 2023-11-08 Biolinq, Inc. Fault detection for microneedle array based continuous analyte monitoring device
AU2022306407A1 (en) 2021-07-07 2024-02-22 The Regents Of The University Of California Wearable, non-intrusive microneedle sensor
CN113977829A (en) * 2021-09-08 2022-01-28 北京宝理泰科技有限公司 Preparation method of hollow microneedle array biosensor
USD1013544S1 (en) 2022-04-29 2024-02-06 Biolinq Incorporated Wearable sensor
USD996999S1 (en) 2021-11-16 2023-08-29 Biolinq Incorporated Wearable sensor
US11957346B2 (en) 2022-02-18 2024-04-16 Kitotech Medical, Inc. Force modulating deep skin staples and instruments
CN114935595B (en) * 2022-04-15 2024-02-06 北京大学 Manufacturing method of microneedle biosensor
USD1012744S1 (en) 2022-05-16 2024-01-30 Biolinq Incorporated Wearable sensor with illuminated display
CN115956929B (en) * 2023-01-09 2023-07-25 华中科技大学 Multi-brain-area electrode array combining recording and optical stimulation and preparation method thereof

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3704194A (en) * 1970-07-02 1972-11-28 Gen Electric Perforated reinforced plastic member and method for making
US3964482A (en) 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US4180232A (en) * 1977-01-13 1979-12-25 Hardigg James S Truss panel mold
JPS5428369A (en) * 1977-08-03 1979-03-02 Yamakawa Tsuneko Method of forming needleelike projection of thermoplastic resin on sheet
US4381963A (en) 1980-07-30 1983-05-03 The University Of Rochester Micro fabrication molding process
US4585991A (en) * 1982-06-03 1986-04-29 Texas Instruments Incorporated Solid state multiprobe testing apparatus
US5135477A (en) 1984-10-29 1992-08-04 Medtronic, Inc. Iontophoretic drug delivery
US4784737A (en) 1986-04-18 1988-11-15 The United States Department Of Energy Electromicroinjection of particles into living cells
US4837049A (en) 1986-06-17 1989-06-06 Alfred E. Mann Foundation For Scientific Research Method of making an electrode array
EP0305123B1 (en) * 1987-08-24 1993-05-05 The Procter & Gamble Company Substantially fluid-impervious microbubbled polymeric web and method and apparatus for making it
US5362307A (en) 1989-01-24 1994-11-08 The Regents Of The University Of California Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic substance
SU1667864A1 (en) 1989-03-23 1991-08-07 Опытный завод энергетического машиностроения Electrostimulation device
EP0429842B1 (en) 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
US5215088A (en) 1989-11-07 1993-06-01 The University Of Utah Three-dimensional electrode device
US5527288A (en) 1990-12-13 1996-06-18 Elan Medical Technologies Limited Intradermal drug delivery device and method for intradermal delivery of drugs
US5279544A (en) 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
TW279133B (en) 1990-12-13 1996-06-21 Elan Med Tech
US5156591A (en) 1990-12-13 1992-10-20 S. I. Scientific Innovations Ltd. Skin electrode construction and transdermal drug delivery device utilizing same
US5252279A (en) * 1991-01-17 1993-10-12 Reinhold Industries Method for making perforated articles
US5312456A (en) 1991-01-31 1994-05-17 Carnegie Mellon University Micromechanical barb and method for making the same
US5256360A (en) 1992-03-25 1993-10-26 Panasonic Technologies, Inc. Method of manufacturing a precision micro-filter
US5318557A (en) 1992-07-13 1994-06-07 Elan Medical Technologies Limited Medication administering device
IE930532A1 (en) 1993-07-19 1995-01-25 Elan Med Tech Liquid material dispenser and valve
US5383512A (en) 1993-01-27 1995-01-24 Midwest Research Institute Method for fabricating a substrate having spaced apart microcapillaries thereon
CA2132277C (en) 1993-10-22 2005-05-10 Giorgio Cirelli Injection device
US5457041A (en) * 1994-03-25 1995-10-10 Science Applications International Corporation Needle array and method of introducing biological substances into living cells using the needle array
KR0134151B1 (en) 1994-05-23 1998-04-14 이형도 Insulin patch
CA2149943C (en) 1994-05-23 1999-07-13 Kwang Kyun Jang Skin perforating device for transdermal medication
US5591139A (en) 1994-06-06 1997-01-07 The Regents Of The University Of California IC-processed microneedles
US5771890A (en) 1994-06-24 1998-06-30 Cygnus, Inc. Device and method for sampling of substances using alternating polarity
US5498235A (en) 1994-09-30 1996-03-12 Becton Dickinson And Company Iontophoresis assembly including patch/controller attachment
US5551953A (en) 1994-10-31 1996-09-03 Alza Corporation Electrotransport system with remote telemetry link
IE72524B1 (en) 1994-11-04 1997-04-23 Elan Med Tech Analyte-controlled liquid delivery device and analyte monitor
AU5740496A (en) 1995-05-22 1996-12-11 General Hospital Corporation, The Micromechanical device and method for enhancing delivery of compounds through the skin
WO1996037256A1 (en) 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical patch for enhancing the delivery of compounds through the skin
DE19525607A1 (en) 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneal drug delivery system
JP2713255B2 (en) 1995-08-11 1998-02-16 日本電気株式会社 Leachate suction device
IE77523B1 (en) 1995-09-11 1997-12-17 Elan Med Tech Medicament delivery device
US5735273A (en) 1995-09-12 1998-04-07 Cygnus, Inc. Chemical signal-impermeable mask
US5645977A (en) * 1995-09-22 1997-07-08 Industrial Technology Research Institute Method of making molds for manufacturing multiple-lead microstructures
US5658515A (en) 1995-09-25 1997-08-19 Lee; Abraham P. Polymer micromold and fabrication process
CA2253549C (en) 1996-06-18 2005-10-25 Alza Corporation Device for enhancing transdermal agent delivery or sampling
US6183434B1 (en) 1996-07-03 2001-02-06 Spectrx, Inc. Multiple mechanical microporation of skin or mucosa
US5928207A (en) 1997-06-30 1999-07-27 The Regents Of The University Of California Microneedle with isotropically etched tip, and method of fabricating such a device
WO1999029364A1 (en) 1997-12-11 1999-06-17 Alza Corporation Device for enhancing transdermal agent flux
WO1999029298A2 (en) 1997-12-11 1999-06-17 Alza Corporation Device for enhancing transdermal agent flux
DK1037686T3 (en) 1997-12-11 2006-01-02 Alza Corp Apparatus for enhancing transdermal flow of agents
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
CA2330207C (en) 1998-06-10 2005-08-30 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6312612B1 (en) 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array

Also Published As

Publication number Publication date
TW512067B (en) 2002-12-01
CA2376283C (en) 2007-08-28
AU5727900A (en) 2000-12-28
CA2689890C (en) 2012-09-04
JP2003501161A (en) 2003-01-14
WO2000074764A1 (en) 2000-12-14
JP4436992B2 (en) 2010-03-24
EP1183064A1 (en) 2002-03-06
US6471903B2 (en) 2002-10-29
US6312612B1 (en) 2001-11-06
US6451240B1 (en) 2002-09-17
US20020020688A1 (en) 2002-02-21
EP1183064B1 (en) 2012-12-19
CA2689890A1 (en) 2000-12-14

Similar Documents

Publication Publication Date Title
CA2376283A1 (en) Method of manufacturing an intracutaneous microneedle array
TWI615258B (en) Light-transmitting stamping die and imprinting method
US6432328B2 (en) Method for forming planar microlens and planar microlens obtained thereby
KR100682534B1 (en) Method for manufacturing microneedle array
EP1275508A3 (en) Method for manufacturing microstructure, method for manufacturing liquid discharge head, and liquid discharge head
JP2007502715A5 (en)
TWI335490B (en) Nano-imprinting process
TW201102281A (en) Multilayer body
US6701652B1 (en) Molded emblem with encapsulated embossed 3-D graphics
KR101365211B1 (en) Method for copy mold manufacture
US7743492B2 (en) Method for forming cast flexible substrate and resultant substrate and electronic device
KR100537722B1 (en) Method and device for ultraviolet continuous curing method for fabrication of micro patterns using drum-type stamper
KR101051291B1 (en) Light guide for backlight unit and manufacturing method thereof
JPH06254868A (en) Manufacture of composite precisely molded product
JP2002321227A (en) Method for manufacturing matrix for molding optical element, method for manufacturing optical element using matrix and optical element by the manufacturing method
JP2007517253A (en) Production of polymer optical waveguides using molds
JP2009066827A (en) Molding method of optical element
JP2003011131A (en) Mold manufacturing method and method for manufacturing optical element
JP2005300715A (en) Method for manufacturing three-dimensional structure
JP2004017477A5 (en)
KR101209479B1 (en) Method for forming structure and method for manufacturing liquid ejecting head
JP4098952B2 (en) Timepiece dial and method for manufacturing the same
US20040201138A1 (en) Mother plate for deep lines pattern impression and manufacturing thereof
KR20130134528A (en) Mold in which micro pattern and nano hologram pattern are molded and method for manufacturing same
TWI420261B (en) Method for manufacturing mold core

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20190607