CA2372001A1 - Magnetic resonance imaging guidewire probe - Google Patents

Magnetic resonance imaging guidewire probe Download PDF

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Publication number
CA2372001A1
CA2372001A1 CA002372001A CA2372001A CA2372001A1 CA 2372001 A1 CA2372001 A1 CA 2372001A1 CA 002372001 A CA002372001 A CA 002372001A CA 2372001 A CA2372001 A CA 2372001A CA 2372001 A1 CA2372001 A1 CA 2372001A1
Authority
CA
Canada
Prior art keywords
probe assembly
guidewire probe
guidewire
helical coil
antenna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002372001A
Other languages
French (fr)
Other versions
CA2372001C (en
Inventor
Albert C. Lardo
Xiaoming Yang
Ergin Atalar
Parag Karmarkar
Elliott R. Mcveigh
Henry R. Halperin
Christine Enger Mcnamara
Paul A. Bottomley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
ClearPoint Neuro Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2372001A1 publication Critical patent/CA2372001A1/en
Application granted granted Critical
Publication of CA2372001C publication Critical patent/CA2372001C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/285—Invasive instruments, e.g. catheters or biopsy needles, specially adapted for tracking, guiding or visualization by NMR
    • G01R33/287—Invasive instruments, e.g. catheters or biopsy needles, specially adapted for tracking, guiding or visualization by NMR involving active visualization of interventional instruments, e.g. using active tracking RF coils or coils for intentionally creating magnetic field inhomogeneities
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/09—Guide wires
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/32—Excitation or detection systems, e.g. using radio frequency signals
    • G01R33/34—Constructional details, e.g. resonators, specially adapted to MR
    • G01R33/34084—Constructional details, e.g. resonators, specially adapted to MR implantable coils or coils being geometrically adaptable to the sample, e.g. flexible coils or coils comprising mutually movable parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/09—Guide wires
    • A61M2025/09058—Basic structures of guide wires
    • A61M2025/09075—Basic structures of guide wires having a core without a coil possibly combined with a sheath
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/09—Guide wires
    • A61M2025/09133—Guide wires having specific material compositions or coatings; Materials with specific mechanical behaviours, e.g. stiffness, strength to transmit torque

Abstract

The invention describes a system, method, and means for an MRI guidewire that can be visible on an MRI; can act as an antenna, and receive MRI signals from surrounding subject matter; and can allow the use of multiple interventional tools without removal of the guide wire from a subject. The antenna (106) extends beyond probe shaft (105) at distal end (109). The probe shaft (105) has a core (101), first electric (102), shield (103), and second dielectric (104).

Claims (89)

1. A guidewire probe assembly suitable for receiving magnetic resonance signals from a sample, comprising:
a probe shaft having a distal end and proximate end comprising a core of non-magnetic material;
a first insulator/dielectric;
a shielding and;
an antenna whip attached to said distal end of said probe shaft;
wherein at least said antenna whip is visible on a magnetic resonance image.
2. The guidewire probe assembly of claim 1, further comprising a second insulator/dielectric.
3. The guidewire probe assembly of claim 1, wherein said core of non-magnetic material is plated with alternating layers of gold and silver.
4. The guidewire probe assembly of claim 1, wherein said core of non-magnetic material is plated with a plurality of layers of conductive metal, said layers of conductive metal comprising one or more of the group of metals consisting of gold, silver, copper and aluminum.
5. The guidewire probe assembly of claim 1 wherein said core of non-magnetic material is fabricated from conductive metal comprising one or more of the group of metals consisting of gold, silver, copper, MR-compatible stainless steel, and aluminum.
6. The guidewire probe assembly of claim 1, wherein said core of non-magnetic material comprises a super-elastic material.
7. The guidewire probe assembly of claim 6 wherein said super-elastic material comprises Nitinol.
8. The guidewire probe antenna assembly of claim 7, wherein said core of non-magnetic material is plated with alternating layers of gold and silver.
9. The guidewire probe assembly of claim 7, wherein said core of non-magnetic material is plated with a plurality of layers of conductive metal, said layers of conductive metal comprising one or more of the group of metals consisting of gold, silver, copper and aluminum.
10. The guidewire probe assembly of claim 1, wherein said core of non-magnetic material comprises a non-metallic material plated with a radio frequency conductive material.
11. The guidewire probe assembly of claim 10, wherein said core of non-metallic material comprises carbon.
12. The guidewire probe assembly of claim 10, wherein said core of non-metallic material comprises glass fiber.
13. The guidewire probe assembly of claim 10, wherein said core of non-metallic material comprises a polymer.
14. The guidewire probe assembly of claim 1, further comprising:
a connector portion for making an electrical connection between said guidewire probe and a mated connector portion electrically attached to an MRI
machine.
15. The guidewire probe assembly of claim 14 whereby said connector enables loading and unloading interventional devices during a procedure without removal of said guidewire probe from a subject.
16. The guidewire probe assembly of claim 15 wherein said connector portion and said mated connector portion snap together.
17. The guidewire probe assembly of claim 15 wherein said mated connector portion clips to said connector portion.
18. The guidewire probe assembly of claim 15 wherein said mated connector portion can be locked by a screw portion in connection with said connector portion.
19. The guidewire probe assembly of claim 15 wherein said mated connector portion is screwably connected to said connector portion.
20. The guidewire probe assembly of claim 15 wherein said connector portion and said mated connector portion connect together in a manner which allows said guidewire probe to rotate freely without rotation of anything connected to said mated connector portion, but while maintaining electric contact between said connector portion and said mated connector portion.
21. The guidewire probe assembly of claim 15 wherein said connector portion and said mated connector portion connect together with a vice-like connection.
22. The guidewire probe assembly of claim 15 wherein said connector portion and said mated connector portion are not in direct electrical contact.
23. The guidewire probe assembly of claim 22 wherein signals are transmitted from said connector portion to said mated connector portion through the use of electromagnetic waves.
24. The guidewire probe assembly of claim 23 wherein said connector portion comprises a solenoid coil.
25. The guidewire probe assembly of claim 23 wherein said mated connector portion comprises a solenoid coil.
26. The guidewire probe assembly of claim 23 wherein said connector portion comprises a loop coil.
27. The guidewire probe assembly of claim 23 wherein said mated connector portion comprises a loop coil.
28. The guidewire probe assembly of claim 1, wherein said antenna whip comprises a substantially linear protrusion from said probe shaft.
29. The guidewire probe assembly of claim 28 wherein said substantially linear protrusion has a curve or hook at an end to facilitate engagement into a complex vessel.
30. The guidewire probe assembly of claim 28, wherein said antenna whip is attached to a helical whip with a proximate end and a distal end, said helical whip comprising coils having a diameter and a spacing.
31. The guidewire probe assembly of claim 30, wherein said helical whip is wrapped around said linear extension of the conductive core.
32. The guidewire probe assembly of claim 30, wherein said helical whip is electronically connected to said antenna whip increasing the electrical length of said antenna whip.
33. The guidewire probe assembly of claim 30, wherein said helical whip is not electrically connected to said antenna whip.
34. The guidewire probe assembly of claim 30, wherein said helical whip is attached to a distal end of said antenna whip.
35. The guidewire probe assembly of claim 30, further comprising a thin insulating material between said antenna whip and said helical whip.
36. The guidewire probe assembly of claim 30 wherein said helical coil is electrically connected to said shielding.
37. The guidewire probe assembly of claim 30, wherein said diameter of said coils varies.
38. The guidewire probe assembly of claim 37, wherein said diameter of said coils is larger at said proximate end of said helical coil antenna than at said distal end of said helical coil antenna.
39. The guidewire probe assembly of claim 37, wherein said diameter of said coils is larger at said distal end of said helical coil antenna than at said proximate end of said helical coil antenna.
40. The guidewire probe assembly of claim 37, wherein said diameter of said coils is larger in at least point between said proximate end and said distal end of said helical coil antenna than it is at at least one of said proximate or said distal end of said helical coil antenna.
41. The guidewire probe assembly of claim 37, wherein said diameter of said coils is smaller in at least point between said proximate end and said distal end of said helical coil antenna than it is at at least one of said proximate or said distal end of said helical coil antenna.
42. The guidewire probe assembly of claim 30, wherein said spacing of said coils varies.
43. The guidewire probe assembly of claim 42, wherein said spacing of said coils is greater at said proximate end of said helical coil antenna than at said distal end of said helical coil antenna.
44. The guidewire probe assembly of claim 42, wherein said spacing of said coils is greater at said distal end of said helical coil antenna than at said proximate end of said helical coil antenna.
45. The guidewire probe assembly of claim 42, wherein said spacing of said coils is greater in at least one point between said proximate end and said distal end of said helical coil antenna than it is at at least one of said distal end of said helical coil antenna or said proximate end of said helical coil antenna.
46. The guidewire probe assembly of claim 42, wherein said spacing of said coils is less in at least one point between said proximate end and said distal end of said helical coil antenna than it is at at least one of said distal end of said helical coil antenna or said proximate end of said helical coil antenna.
47. The guidewire probe assembly of claim 1, wherein an outer surface of said probe shaft is insulated with a biocompatible material or coating.
48. The guidewire probe assembly of claim 1 wherein said antenna whip comprises a helical whip with a proximate end and a distal end, said helical whip having coils with a diameter and a spacing.
49. The guidewire probe assembly of claim 48 wherein said helical whip comprises at least one of copper, gold, silver, or aluminum wire.
50. The guidewire probe assembly of claim 48 wherein said antenna whip is covered by a biocompatible material or covering.
51. The guidewire probe assembly of claim 50 wherein the electrical length of said helical coil is chosen so as to compensate for said biocompatible material or covering.
52. The guidewire probe assembly of claim 48, wherein said helical whip is electrically connected to said core at least at one point.
53. The guidewire probe assembly of claim 48, wherein said diameter of said coils varies.
54. The guidewire probe assembly of claim 53, wherein said diameter of said coils is larger at said proximate end of said helical coil antenna than at said distal end of said helical coil antenna.
55. The guidewire probe assembly of claim 53, wherein said diameter of said coils is larger at said distal end of said helical coil antenna than at said proximate end of said helical coil antenna.
56. The guidewire probe assembly of claim 53, wherein said diameter of said coils is larger in at least point between said proximate end and said distal end of said helical coil antenna than it is at at least one of said proximate or said distal end of said helical coil antenna.
57. The guidewire probe assembly of claim 53, wherein said diameter of said coils is smaller in at least point between said proximate end and said distal end of said helical coil antenna than it is at at least one of said proximate or said distal end of said helical coil antenna.
58. The guidewire probe assembly of claim 48, wherein said spacing of said coils varies.
59. The guidewire probe assembly of claim 58, wherein said spacing of said coils is greater at said proximate end of said helical coil antenna than at said distal end of said helical coil antenna.
60. The guidewire probe assembly of claim 58, wherein said spacing of said coils is greater at said distal end of said helical coil antenna than at said proximate end of said helical coil antenna.
61. The guidewire probe assembly of claim 58, wherein said spacing of said coils is greater in at least one point between said proximate end and said distal end of said helical coil antenna than it is at at least one of said distal end of said helical coil antenna or said proximate end of said helical coil antenna.
62. The guidewire probe assembly of claim 58, wherein said spacing of said coils is less in at least one point between said proximate end and said distal end of said helical coil antenna than it is at at least one of said distal end of said helical coil antenna or said proximate end of said helical coil antenna.
63. The guidewire probe assembly of claim 1, wherein the total diameter of said guidewire probe is between about 0.010 - 0.040 inches.
64. The guidewire probe assembly of claim 1, wherein the total diameter of said guidewire probe is between 5/1000 inch and 0.5 inch.
65. The guidewire probe assembly of claim 1, wherein said first insulator/dielectric comprises a low dielectric loss, low dielectric constant material.
66. The guidewire probe assembly of claim 1, wherein said guidewire probe is at least partially flexible.
67. The guidewire probe assembly of claim 1, wherein said guidewire probe is steerable inside a subject.
68. The guidewire probe assembly of claim 1, wherein said antenna whip is flexible.
69. The guidewire probe assembly of claim 1, wherein said antenna whip is loopless.
70. The guidewire probe assembly according to claim 1, further comprising a balun circuit.
71. The guidewire probe assembly of claim 70, wherein said balun circuit comprises a tuned balun circuit.
72. The guidewire probe assembly of claim 1, further comprising a helical coil placed around said probe shaft.
73. The guidewire probe assembly of claim 1, wherein said shielding comprises a helical coil.
74. The guidewire probe assembly of claim 1, wherein said probe shaft is tapered.
75. A method of performing an interventional procedure comprising the steps of:
positioning a subject in a main magnetic field;
introducing a guidewire probe assembly into the subject;
locating an antenna on said guidewire probe adjacent to a region of interest;
and, performing a diagnostic interventional procedure using a magnetic resonance imaging signal from said antenna as a guide.
76. A method of manufacturing a guidewire probe assembly, comprising the steps of:
Attaching a first insulator to a non-magnetic core to create a core-insulator assembly;
Loading a shielding onto a proximate portion of said core-insulator assembly;
and, Attaching an antenna whip to a distal portion of said core assembly; and,
77. The method of manufacturing a guidewire probe assembly according to claim 76, further comprising, loading an outer insulator over said antenna whip, said shielding, and said core-insulator assembly.
78. The method of manufacturing a guidewire probe assembly according to claim 76, wherein said step of attaching said first insulator to said non-magnetic core comprises an extrusion step.
79. The method of manufacturing a guidewire probe assembly according to claim 76, wherein said step of attaching said primary insulator to said non-magnetic core comprises a drawing step.
80. The method of manufacturing a guidewire probe assembly according to claim 76, wherein said step of attaching said first insulator to said non-magnetic core comprises applying a heat-shrink tubing.
81. The method of manufacturing a guidewire probe assembly according to claim 76, wherein said step of loading a shielding onto said proximate portion of said core-insulator assembly comprises the step of applying a braiding.
82. The method of manufacturing a guidewire probe assembly according to claim 76, wherein said step of loading a shielding onto said proximate portion of said core-insulator assembly comprises a painting step.
83. The method of manufacturing a guidewire probe assembly according to claim 76, wherein said step of loading a shielding onto said proximate portion of said core-insulator assembly comprises a plating step.
84. The method of manufacturing a guidewire probe assembly according to claim 76, wherein said step of loading a shielding onto said proximate portion of said core-insulator assembly comprises a sputtering step.
85. A system for performing an interventional procedure comprising A subject;
A plurality of interventional tools;
An MRI machine for use on said subject; and A guidewire probe assembly that is visible on an image produced by said MRI
machine and is inserted in said subject;
wherein said plurality of interventional tools can be loaded and unloaded using said guidewire probe assembly without removing said guidewire probe assembly from said subject.
86. The system of claim 83 further comprising an interface box between said guidewire probe and said MRI machine.
87. A means for performing an interventional procedure comprising:
means for obtaining an MRI image of a subject;
a probe means visible on said MRI image and capable of guiding tool means within said subject; and a plurality of tool means for performing said interventional procedure.
88. A connector for use to connect a guidewire to an electrical source wherein said connector enables loading and unloading interventional devices during a procedure without removal of said guidewire from a subject.
89. A device suitable for insertion into a subject that comprises:
A helical coil;
wherein said helical coil is suitable for use as a magnetic resonance antenna.
CA2372001A 1999-04-15 2000-04-13 Magnetic resonance imaging guidewire probe Expired - Lifetime CA2372001C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12936499P 1999-04-15 1999-04-15
US60/129,364 1999-04-15
US09/536,090 US6675033B1 (en) 1999-04-15 2000-03-24 Magnetic resonance imaging guidewire probe
US09/536,090 2000-03-24
PCT/US2000/009875 WO2000064003A2 (en) 1999-04-15 2000-04-13 Magnetic resonance imaging guidewire probe

Publications (2)

Publication Number Publication Date
CA2372001A1 true CA2372001A1 (en) 2000-10-26
CA2372001C CA2372001C (en) 2010-10-19

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CA2372001A Expired - Lifetime CA2372001C (en) 1999-04-15 2000-04-13 Magnetic resonance imaging guidewire probe

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US (1) US6675033B1 (en)
EP (1) EP1169749B1 (en)
JP (1) JP4851010B2 (en)
AT (1) ATE469360T1 (en)
AU (1) AU779202B2 (en)
CA (1) CA2372001C (en)
DE (1) DE60044456D1 (en)
ES (1) ES2346633T3 (en)
WO (1) WO2000064003A2 (en)

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US6675033B1 (en) 2004-01-06
CA2372001C (en) 2010-10-19
ATE469360T1 (en) 2010-06-15
WO2000064003A2 (en) 2000-10-26
WO2000064003A9 (en) 2002-06-27
JP4851010B2 (en) 2012-01-11
AU779202B2 (en) 2005-01-13
JP2003525654A (en) 2003-09-02
EP1169749A2 (en) 2002-01-09
DE60044456D1 (en) 2010-07-08
WO2000064003A3 (en) 2001-01-18
WO2000064003A8 (en) 2001-05-03
AU4236800A (en) 2000-11-02
EP1169749A4 (en) 2006-08-02
ES2346633T3 (en) 2010-10-19

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