CA2355044A1 - Controlled removal of biological membrane by pyrotechnic charge for transmembrane transport - Google Patents

Controlled removal of biological membrane by pyrotechnic charge for transmembrane transport Download PDF

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Publication number
CA2355044A1
CA2355044A1 CA002355044A CA2355044A CA2355044A1 CA 2355044 A1 CA2355044 A1 CA 2355044A1 CA 002355044 A CA002355044 A CA 002355044A CA 2355044 A CA2355044 A CA 2355044A CA 2355044 A1 CA2355044 A1 CA 2355044A1
Authority
CA
Canada
Prior art keywords
biological membrane
pyrotechnic charge
controlled removal
transmembrane transport
transmembrane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002355044A
Other languages
French (fr)
Other versions
CA2355044C (en
Inventor
Jonathan A. Eppstein
Michael R. Hatch
Joseph Papp
Mark L. Faupel
Krishna Kumar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nitto Denko Corp
Altea Technologies Inc
Original Assignee
Spectrx, Inc.
Jonathan A. Eppstein
Michael R. Hatch
Joseph Papp
Mark L. Faupel
Krishna Kumar
Altea Technologies, Inc.
Altea Development Corp.
Altea Therapeutics Corporation
Midcap Financial, Llc
Midcap Funding Iii, Llc
Nitto Denko Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spectrx, Inc., Jonathan A. Eppstein, Michael R. Hatch, Joseph Papp, Mark L. Faupel, Krishna Kumar, Altea Technologies, Inc., Altea Development Corp., Altea Therapeutics Corporation, Midcap Financial, Llc, Midcap Funding Iii, Llc, Nitto Denko Corporation filed Critical Spectrx, Inc.
Publication of CA2355044A1 publication Critical patent/CA2355044A1/en
Application granted granted Critical
Publication of CA2355044C publication Critical patent/CA2355044C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0047—Sonopheresis, i.e. ultrasonically-enhanced transdermal delivery, electroporation of a pharmacologically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A61B2010/008—Interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A61B2017/00761—Removing layer of skin tissue, e.g. wrinkles, scars or cancerous tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2046—Media being expelled from injector by gas generation, e.g. explosive charge

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Anesthesiology (AREA)
  • Biophysics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Pathology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • External Artificial Organs (AREA)

Abstract

A method and device for forming artificial openings in a biological membrane with a pyrotechnic charge that is exploded in a controlled manner in proximity of the biological membrane to form the artificial opening(s) therein. The method and device are useful in connection with transdermal delivery and monitoring applications.
CA002355044A 1998-07-14 1999-07-14 Controlled removal of biological membrane by pyrotechnic charge for transmembrane transport Expired - Fee Related CA2355044C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US9273198P 1998-07-14 1998-07-14
US60/092,731 1998-07-14
US13805099P 1999-06-08 1999-06-08
US60/138,050 1999-06-08
PCT/US1999/015967 WO2000003758A1 (en) 1998-07-14 1999-07-14 Controlled removal of biological membrane by pyrotechnic charge for transmembrane transport

Publications (2)

Publication Number Publication Date
CA2355044A1 true CA2355044A1 (en) 2000-01-27
CA2355044C CA2355044C (en) 2009-02-24

Family

ID=26785984

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002355044A Expired - Fee Related CA2355044C (en) 1998-07-14 1999-07-14 Controlled removal of biological membrane by pyrotechnic charge for transmembrane transport

Country Status (11)

Country Link
US (2) US6352506B1 (en)
EP (2) EP1987854A1 (en)
AT (1) ATE413899T1 (en)
AU (1) AU759738B2 (en)
CA (1) CA2355044C (en)
CY (1) CY1108763T1 (en)
DE (1) DE69939906D1 (en)
DK (1) DK1124607T3 (en)
ES (1) ES2317699T3 (en)
PT (1) PT1124607E (en)
WO (1) WO2000003758A1 (en)

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Also Published As

Publication number Publication date
AU4996499A (en) 2000-02-07
CA2355044C (en) 2009-02-24
EP1124607A1 (en) 2001-08-22
DE69939906D1 (en) 2008-12-24
CY1108763T1 (en) 2014-04-09
ES2317699T3 (en) 2009-04-16
US6730028B2 (en) 2004-05-04
PT1124607E (en) 2008-12-31
EP1124607B1 (en) 2008-11-12
US6352506B1 (en) 2002-03-05
AU759738B2 (en) 2003-04-17
EP1987854A1 (en) 2008-11-05
WO2000003758A1 (en) 2000-01-27
DK1124607T3 (en) 2009-01-26
US20020091311A1 (en) 2002-07-11
ATE413899T1 (en) 2008-11-15

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