CA2353868A1 - Composite arrays utilizing microspheres - Google Patents

Composite arrays utilizing microspheres Download PDF

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Publication number
CA2353868A1
CA2353868A1 CA002353868A CA2353868A CA2353868A1 CA 2353868 A1 CA2353868 A1 CA 2353868A1 CA 002353868 A CA002353868 A CA 002353868A CA 2353868 A CA2353868 A CA 2353868A CA 2353868 A1 CA2353868 A1 CA 2353868A1
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CA
Canada
Prior art keywords
microspheres
array
subpopulation
substrate
location
Prior art date
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Granted
Application number
CA002353868A
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French (fr)
Other versions
CA2353868C (en
Inventor
Mark S. Chee
Steven R. Auger
John R. Stuelpnagel
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Illumina Inc
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Individual
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Application filed by Individual filed Critical Individual
Priority to CA2729739A priority Critical patent/CA2729739C/en
Publication of CA2353868A1 publication Critical patent/CA2353868A1/en
Application granted granted Critical
Publication of CA2353868C publication Critical patent/CA2353868C/en
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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00382—Stamping
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00646—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports
    • B01J2219/00648—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports by the use of solid beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/924—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis using nanostructure as support of dna analysis

Abstract

The invention relates to sensor compositions comprising a composite array of individual arrays, to allow for simultaneous processing of a number of samples.
The invention further provides methods of making and using the composite arrays.

Claims (19)

1. A composite array composition comprising:
a) a substrate with a surface comprising a plurality of assay locations, each assay location comprising a plurality of discrete sites; and b) a population of microspheres comprising at least a first and a second subpopulation, wherein each subpopulation comprises a bioactive agent;
wherein said microspheres are distributed on each of said assay locations.
2. A composition according to claim 1 wherein each of said assay locations comprises a substantially similar set of bioactive agents.
3. A composition according to claim 1 wherein said substrate is a microtiter plate and each assay location is a microtiter well.
4. A composition according to claim 1 wherein each discrete site is a bead well.
5. A composition according to claim 1 wherein each of said subpopulations further comprise an optical signature capable of identifying said bioactive agent.
6. A composition according to claim 1 wherein each of said subpopulations further comprise an identifier binding ligand that will bind a decoder binding ligand such that the identification of the bioactive agent can be elucidated.
7. A composite array composition comprising:
a) a first substrate with a surface comprising a plurality of assay locations;
b) a second substrate comprising a plurality of array locations, each array location comprising discrete sites; and c) a population of microspheres comprising at least a first and a second subpopulation, wherein each subpopulation comprises a bioactive agent;
wherein said microspheres are distributed on each of said array locations.
8. A composition according to claim 7 wherein said first substrate is a microtiter plate.
9. A composition according to claim 7 or 8 wherein said second substrate comprises a plurality of fiber optic bundles comprising a plurality of individual fibers, each bundle comprising an array location, and each individual fiber comprising a bead well.
10. A composition according to claim 7 wherein each of said subpopulations further comprise an optical signature capable of identifying said bioactive agent.
11. A composition according to claim 7 wherein each of said subpopulations further comprise an identifier binding ligand that will bind a decoder binding ligand such that the identification of the bioactive agent can be elucidated.
12. A method of decoding an array composition comprising a) providing an array composition comprising:
i) a substrate with a surface comprising a plurality of assay locations, each assay location comprising discrete sites; and ii) a population of microspheres comprising at least a first and a second subpopulation, wherein each subpopulation comprises a bioactive agent;
wherein said microspheres are distributed on said sites;
b) adding a plurality of decoding binding ligands to said array composition to identify the location of at least a plurality of the bioactive agents.
13. A method of decoding an array composition comprising a) providing an array composition comprising:
i) a substrate with a surface comprising a plurality of array locations, each array location comprising discrete sites; and ii) a population of microspheres comprising at least a first and a second subpopulation, wherein each subpopulation comprises a bioactive agent;
wherein said microspheres are distributed on said sites;
b) adding a plurality of decoding binding ligands to said array composition to identify the location of at least a plurality of the bioactive agents.
14. A method according to claim 12 or 13 wherein at least one subpopulation of microspheres comprises an identifier binding ligand to which a decoding binding ligand can bind.
15. A method according to claim 12 or 13 wherein said decoding binding ligands bind to said bioactive agents.
16. A method according to claim 12 or 13 wherein said decoding binding ligands are labeled.
17. A method according to claim 12 or 13 wherein the location of each subpopulation is determined.
18. A method of determining the presence of one or more target analytes in one or more samples comprising:

a) contacting said sample with a composition comprising:
i) a substrate with a surface comprising a plurality of assay locations, each assay location comprising discrete sites; and ii) a population of microspheres comprising at least a first and a second subpopulation each comprising a bioactive agent;
wherein said microspheres are distributed on said surface such that said discrete sites contain microspheres; and b) determining the presence or absence of said target analyte.
19. A method of determining the presence of one or more target analytes in one or more samples comprising:
a) adding said sample to a first substrate comprising a plurality of assay locations, such that said sample is contained at a plurality of said assay locations;
b) contacting said sample with a second substrate comprising:
i) a surface comprising a plurality of array locations, each array location comprising discrete sites; and ii) a population of microspheres comprising at least a first and a second subpopulation each comprising a bioactive agent;
wherein said microspheres are distributed on said surface such that said discrete sites contain microspheres; and b) determining the presence or absence of said target analyte.
CA2353868A 1998-12-28 1999-12-28 Composite arrays utilizing microspheres Expired - Lifetime CA2353868C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2729739A CA2729739C (en) 1998-12-28 1999-12-28 Composite arrays utilizing microspheres

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11396898P 1998-12-28 1998-12-28
US60/113,968 1998-12-28
US09/256,943 US6429027B1 (en) 1998-12-28 1999-02-24 Composite arrays utilizing microspheres
US09/256,943 1999-02-24
PCT/US1999/031022 WO2000039587A1 (en) 1998-12-28 1999-12-28 Composite arrays utilizing microspheres

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2729739A Division CA2729739C (en) 1998-12-28 1999-12-28 Composite arrays utilizing microspheres

Publications (2)

Publication Number Publication Date
CA2353868A1 true CA2353868A1 (en) 2000-07-06
CA2353868C CA2353868C (en) 2011-03-29

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ID=26811698

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CA2729739A Expired - Lifetime CA2729739C (en) 1998-12-28 1999-12-28 Composite arrays utilizing microspheres
CA2353868A Expired - Lifetime CA2353868C (en) 1998-12-28 1999-12-28 Composite arrays utilizing microspheres

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CA2729739A Expired - Lifetime CA2729739C (en) 1998-12-28 1999-12-28 Composite arrays utilizing microspheres

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US (3) US6429027B1 (en)
EP (3) EP1141712B2 (en)
JP (2) JP3566653B2 (en)
AT (2) ATE300047T1 (en)
AU (1) AU775056B2 (en)
CA (2) CA2729739C (en)
DE (3) DE69941068D1 (en)
WO (1) WO2000039587A1 (en)

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