CA2346860A1 - Multi-well microfiltration apparatus - Google Patents

Multi-well microfiltration apparatus Download PDF

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Publication number
CA2346860A1
CA2346860A1 CA002346860A CA2346860A CA2346860A1 CA 2346860 A1 CA2346860 A1 CA 2346860A1 CA 002346860 A CA002346860 A CA 002346860A CA 2346860 A CA2346860 A CA 2346860A CA 2346860 A1 CA2346860 A1 CA 2346860A1
Authority
CA
Canada
Prior art keywords
well
provides multi
arrangements
filtrate
array
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002346860A
Other languages
French (fr)
Other versions
CA2346860C (en
Inventor
Stephen E. Moring
Kevin S. Bodner
Jason H. Halsey
Jon Hoshizaki
Joseph Jackson
Alfred P. Madden
Mark F. Oldham
Mark T. Reed
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Applied Biosystems LLC
Original Assignee
Pe Corporation (Ny)
Stephen E. Moring
Kevin S. Bodner
Jason H. Halsey
Jon Hoshizaki
Joseph Jackson
Alfred P. Madden
Mark F. Oldham
Mark T. Reed
The Perkin-Elmer Corporation
Applera Corporation
Applied Biosystems Inc.
Applied Biosystems, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pe Corporation (Ny), Stephen E. Moring, Kevin S. Bodner, Jason H. Halsey, Jon Hoshizaki, Joseph Jackson, Alfred P. Madden, Mark F. Oldham, Mark T. Reed, The Perkin-Elmer Corporation, Applera Corporation, Applied Biosystems Inc., Applied Biosystems, Llc filed Critical Pe Corporation (Ny)
Priority to CA002478306A priority Critical patent/CA2478306A1/en
Publication of CA2346860A1 publication Critical patent/CA2346860A1/en
Application granted granted Critical
Publication of CA2346860C publication Critical patent/CA2346860C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/18—Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B01L3/50255—Multi-well filtration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B01L2400/049—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics vacuum
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465—Separating and mixing arrangements
    • G01N2035/00475—Filters
    • G01N2035/00485—Filters combined with sample carriers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N35/1016—Control of the volume dispensed or introduced
    • G01N2035/102—Preventing or detecting loss of fluid by dripping
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/028—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065—Multiple transfer devices
    • G01N35/1074—Multiple transfer devices arranged in a two-dimensional array
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation

Abstract

The present invention provides multi-well plates and column arrays in which samples (e.g., cell lysates containing nucleic acids of interest, such as RNA) can be analyzed and/or processed. In one embodiment, the microfiltration arrangement is a multilayer structure, including: (i) a column plate having an array of minicolumns into which samples can be placed; (ii) a discrete filter element disposed in each minicolumn; (iii) a drip-director plate having a corresponding array of drip directors through which filtrate may egress;
and (iv) a receiving-well plate having a corresponding array of receiving wells into which filtrate can flow. The invention provides multi-well microfiltration arrangements that are relatively simple to manufacture and that overcome many of the problems associated with the prior arrangements relating to:
(i) cross-contamination due to wicking across a common filter sheet or (ii) individual filter elements entrapping sample constituents within substantial dead volumes. Further, the invention provides multi-well microfiltration arrangements that adequately support discrete filter elements disposed in the wells without creating substantial preferential flow.
additionally, the invention provides multi-well microfiltration arrangements that avoid cross-contamination due to aerosol formation, pendant drops and/or splattering. Other disclosed features of the invention provide for the automated covering or heat-sealing of filtrate samples separately collected in an array of wells.
CA002346860A 1998-10-29 1999-10-28 Multi-well microfiltration apparatus Expired - Fee Related CA2346860C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002478306A CA2478306A1 (en) 1998-10-29 1999-10-28 Multi-well microfiltration apparatus

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/182,946 US6159368A (en) 1998-10-29 1998-10-29 Multi-well microfiltration apparatus
US09/182,946 1998-10-29
PCT/US1999/025579 WO2000025922A2 (en) 1998-10-29 1999-10-28 Multi-well microfiltration apparatus

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA002478306A Division CA2478306A1 (en) 1998-10-29 1999-10-28 Multi-well microfiltration apparatus

Publications (2)

Publication Number Publication Date
CA2346860A1 true CA2346860A1 (en) 2000-05-11
CA2346860C CA2346860C (en) 2005-01-04

Family

ID=22670739

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002346860A Expired - Fee Related CA2346860C (en) 1998-10-29 1999-10-28 Multi-well microfiltration apparatus

Country Status (9)

Country Link
US (6) US6159368A (en)
EP (2) EP1124637B1 (en)
JP (3) JP3725029B2 (en)
AT (1) ATE257036T1 (en)
AU (1) AU756147B2 (en)
CA (1) CA2346860C (en)
DE (1) DE69913978T2 (en)
ES (1) ES2212652T3 (en)
WO (1) WO2000025922A2 (en)

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* Cited by examiner, † Cited by third party
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EP1124637B1 (en) 2004-01-02
US6451261B1 (en) 2002-09-17
US6506343B1 (en) 2003-01-14
EP1124637A2 (en) 2001-08-22
AU756147B2 (en) 2003-01-02
ES2212652T3 (en) 2004-07-16
WO2000025922A2 (en) 2000-05-11
JP2004354393A (en) 2004-12-16
CA2346860C (en) 2005-01-04
DE69913978D1 (en) 2004-02-05
JP3725029B2 (en) 2005-12-07
US6159368A (en) 2000-12-12
ATE257036T1 (en) 2004-01-15
JP2007263966A (en) 2007-10-11
US20020179520A1 (en) 2002-12-05
US6338802B1 (en) 2002-01-15
US6783732B2 (en) 2004-08-31
US20030215956A1 (en) 2003-11-20
JP2002528265A (en) 2002-09-03
WO2000025922A3 (en) 2000-10-19
AU1518400A (en) 2000-05-22
EP1336433A1 (en) 2003-08-20
DE69913978T2 (en) 2004-12-23

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