CA2333875A1 - Redox reversible bipyridyl osmium complex conjugates - Google Patents
Redox reversible bipyridyl osmium complex conjugates Download PDFInfo
- Publication number
- CA2333875A1 CA2333875A1 CA002333875A CA2333875A CA2333875A1 CA 2333875 A1 CA2333875 A1 CA 2333875A1 CA 002333875 A CA002333875 A CA 002333875A CA 2333875 A CA2333875 A CA 2333875A CA 2333875 A1 CA2333875 A1 CA 2333875A1
- Authority
- CA
- Canada
- Prior art keywords
- redox
- reversible
- complex conjugates
- osmium complex
- redox reversible
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000002441 reversible effect Effects 0.000 title abstract 3
- 229910052762 osmium Inorganic materials 0.000 title abstract 2
- -1 bipyridyl osmium Chemical compound 0.000 title 1
- 238000007812 electrochemical assay Methods 0.000 abstract 2
- 0 CNC(CC=CCC(*SCC1CCN2)C1NC2=O)=* Chemical compound CNC(CC=CCC(*SCC1CCN2)C1NC2=O)=* 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System compounds of the platinum group
- C07F15/002—Osmium compounds
- C07F15/0026—Osmium compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
- G01N27/3277—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction being a redox reaction, e.g. detection by cyclic voltammetry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
- G01N33/721—Haemoglobin
- G01N33/723—Glycosylated haemoglobin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/795—Porphyrin- or corrin-ring-containing peptides
- G01N2333/805—Haemoglobins; Myoglobins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
- G01N2458/30—Electrochemically active labels
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/805—Optical property
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/806—Electrical property or magnetic property
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/105831—Protein or peptide standard or control [e.g., hemoglobin, etc.]
Abstract
Novel bipyridyl-osmium complex conjugates, their preparation, and their use in electrochemical assays are described. The redox reversible-osmium complexes can be prepared to exhibit unique reversible redox potentials and can thus be used in combination with other electroactive redox reversible species having redox potentials differing by at least 50 millivolts in electrochemical assays designed for use of multiple electroactive species in the same cell and in the same sample without interference between the two or more redox coupled conjugate systems.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8757698P | 1998-06-01 | 1998-06-01 | |
US60/087,576 | 1998-06-01 | ||
PCT/US1999/011891 WO1999062919A1 (en) | 1998-06-01 | 1999-05-28 | Redox reversible bipyridyl osmium complex conjugates |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2333875A1 true CA2333875A1 (en) | 1999-12-09 |
CA2333875C CA2333875C (en) | 2005-10-11 |
Family
ID=22205995
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002333732A Expired - Fee Related CA2333732C (en) | 1998-06-01 | 1999-05-28 | Redox reversible imidazole-osmium complex conjugates |
CA002333686A Expired - Fee Related CA2333686C (en) | 1998-06-01 | 1999-05-28 | Method and device for electrochemical immunoassay of multiple analytes |
CA002333875A Expired - Fee Related CA2333875C (en) | 1998-06-01 | 1999-05-28 | Redox reversible bipyridyl osmium complex conjugates |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002333732A Expired - Fee Related CA2333732C (en) | 1998-06-01 | 1999-05-28 | Redox reversible imidazole-osmium complex conjugates |
CA002333686A Expired - Fee Related CA2333686C (en) | 1998-06-01 | 1999-05-28 | Method and device for electrochemical immunoassay of multiple analytes |
Country Status (8)
Country | Link |
---|---|
US (5) | US6352824B1 (en) |
EP (3) | EP1084133B1 (en) |
AT (3) | ATE222915T1 (en) |
AU (3) | AU4215799A (en) |
CA (3) | CA2333732C (en) |
DE (3) | DE69902662T2 (en) |
ES (3) | ES2182530T3 (en) |
WO (3) | WO1999062919A1 (en) |
Families Citing this family (149)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6036924A (en) | 1997-12-04 | 2000-03-14 | Hewlett-Packard Company | Cassette of lancet cartridges for sampling blood |
US6391005B1 (en) | 1998-03-30 | 2002-05-21 | Agilent Technologies, Inc. | Apparatus and method for penetration with shaft having a sensor for sensing penetration depth |
US6294281B1 (en) | 1998-06-17 | 2001-09-25 | Therasense, Inc. | Biological fuel cell and method |
US6338790B1 (en) | 1998-10-08 | 2002-01-15 | Therasense, Inc. | Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator |
US8268143B2 (en) * | 1999-11-15 | 2012-09-18 | Abbott Diabetes Care Inc. | Oxygen-effect free analyte sensor |
US6605201B1 (en) * | 1999-11-15 | 2003-08-12 | Therasense, Inc. | Transition metal complexes with bidentate ligand having an imidazole ring and sensor constructed therewith |
US8444834B2 (en) | 1999-11-15 | 2013-05-21 | Abbott Diabetes Care Inc. | Redox polymers for use in analyte monitoring |
DE10015816A1 (en) * | 2000-03-30 | 2001-10-18 | Infineon Technologies Ag | Biosensor chip |
US7223330B2 (en) * | 2000-03-30 | 2007-05-29 | Siemens Aktiengesellschaft | Biosensor, biosensor array and method for detecting macromolecular biopolymers with a biosensor |
CN100457887C (en) * | 2000-05-03 | 2009-02-04 | 高振智 | Biological identification system with integrated sensor chip |
CA2733852A1 (en) * | 2000-07-14 | 2002-01-24 | Lifescan, Inc. | Electrochemical method for measuring chemical reaction rates |
CZ2003409A3 (en) * | 2000-07-14 | 2003-10-15 | Lifescan, Inc. | Electrochemical measuring method of chemical reaction rate |
EP1319949A4 (en) * | 2000-09-20 | 2005-06-01 | Yuko Seino | Reaction detecting method, immunoreaction detecting method and device |
GB0026276D0 (en) * | 2000-10-27 | 2000-12-13 | Univ Ulster | Method for chlorine plasma modification of silver electrodes |
US20020106708A1 (en) * | 2000-11-13 | 2002-08-08 | Sigma-Aldrich Co. | Assays reagents and kits for detecting or determining the concentration of analytes |
US8641644B2 (en) | 2000-11-21 | 2014-02-04 | Sanofi-Aventis Deutschland Gmbh | Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means |
US6572745B2 (en) | 2001-03-23 | 2003-06-03 | Virotek, L.L.C. | Electrochemical sensor and method thereof |
US6576102B1 (en) | 2001-03-23 | 2003-06-10 | Virotek, L.L.C. | Electrochemical sensor and method thereof |
US6676816B2 (en) * | 2001-05-11 | 2004-01-13 | Therasense, Inc. | Transition metal complexes with (pyridyl)imidazole ligands and sensors using said complexes |
US8226814B2 (en) * | 2001-05-11 | 2012-07-24 | Abbott Diabetes Care Inc. | Transition metal complexes with pyridyl-imidazole ligands |
US8070934B2 (en) | 2001-05-11 | 2011-12-06 | Abbott Diabetes Care Inc. | Transition metal complexes with (pyridyl)imidazole ligands |
NZ511705A (en) * | 2001-05-14 | 2004-03-26 | Horticulture & Food Res Inst | Methods and rapid immunoassay device for detecting progesterone and other steroids |
US7005273B2 (en) | 2001-05-16 | 2006-02-28 | Therasense, Inc. | Method for the determination of glycated hemoglobin |
US20020179457A1 (en) * | 2001-05-18 | 2002-12-05 | Adam Heller | Electrochemical method for high-throughput screening of minute quantities of candidate compounds |
EP1404235A4 (en) | 2001-06-12 | 2008-08-20 | Pelikan Technologies Inc | Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge |
ATE497731T1 (en) | 2001-06-12 | 2011-02-15 | Pelikan Technologies Inc | DEVICE FOR INCREASING THE SUCCESS RATE OF BLOOD YIELD OBTAINED BY A FINGER PICK |
EP1404233B1 (en) | 2001-06-12 | 2009-12-02 | Pelikan Technologies Inc. | Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties |
JP4149911B2 (en) | 2001-06-12 | 2008-09-17 | ペリカン テクノロジーズ インコーポレイテッド | Electric lancet actuator |
US7981056B2 (en) | 2002-04-19 | 2011-07-19 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
US8337419B2 (en) | 2002-04-19 | 2012-12-25 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US9795747B2 (en) | 2010-06-02 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for lancet actuation |
US7682318B2 (en) | 2001-06-12 | 2010-03-23 | Pelikan Technologies, Inc. | Blood sampling apparatus and method |
US9226699B2 (en) | 2002-04-19 | 2016-01-05 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling module with a continuous compression tissue interface surface |
US7025774B2 (en) | 2001-06-12 | 2006-04-11 | Pelikan Technologies, Inc. | Tissue penetration device |
US9427532B2 (en) | 2001-06-12 | 2016-08-30 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US6562581B2 (en) * | 2001-08-31 | 2003-05-13 | Portascience | Method for quantitative determination of glycated hemoglobin |
US6861224B2 (en) * | 2001-11-02 | 2005-03-01 | Fujitsu Limited | Protein detecting device |
US20030170698A1 (en) * | 2002-01-04 | 2003-09-11 | Peter Gascoyne | Droplet-based microfluidic oligonucleotide synthesis engine |
US20060008464A1 (en) * | 2002-04-08 | 2006-01-12 | Chaim Gilon | Histone conjugates and uses thereof |
US8267870B2 (en) | 2002-04-19 | 2012-09-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling with hybrid actuation |
US8579831B2 (en) | 2002-04-19 | 2013-11-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US9248267B2 (en) | 2002-04-19 | 2016-02-02 | Sanofi-Aventis Deustchland Gmbh | Tissue penetration device |
US8702624B2 (en) | 2006-09-29 | 2014-04-22 | Sanofi-Aventis Deutschland Gmbh | Analyte measurement device with a single shot actuator |
US7226461B2 (en) | 2002-04-19 | 2007-06-05 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device with sterility barrier release |
US7648468B2 (en) | 2002-04-19 | 2010-01-19 | Pelikon Technologies, Inc. | Method and apparatus for penetrating tissue |
US7892183B2 (en) | 2002-04-19 | 2011-02-22 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
US7229458B2 (en) | 2002-04-19 | 2007-06-12 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7976476B2 (en) | 2002-04-19 | 2011-07-12 | Pelikan Technologies, Inc. | Device and method for variable speed lancet |
US7674232B2 (en) | 2002-04-19 | 2010-03-09 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8221334B2 (en) | 2002-04-19 | 2012-07-17 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7717863B2 (en) | 2002-04-19 | 2010-05-18 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7491178B2 (en) | 2002-04-19 | 2009-02-17 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7547287B2 (en) | 2002-04-19 | 2009-06-16 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US9795334B2 (en) | 2002-04-19 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7371247B2 (en) | 2002-04-19 | 2008-05-13 | Pelikan Technologies, Inc | Method and apparatus for penetrating tissue |
US7232451B2 (en) | 2002-04-19 | 2007-06-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7909778B2 (en) | 2002-04-19 | 2011-03-22 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8784335B2 (en) | 2002-04-19 | 2014-07-22 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling device with a capacitive sensor |
US8360992B2 (en) | 2002-04-19 | 2013-01-29 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7291117B2 (en) | 2002-04-19 | 2007-11-06 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US9314194B2 (en) | 2002-04-19 | 2016-04-19 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US7331931B2 (en) | 2002-04-19 | 2008-02-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7175642B2 (en) | 2002-04-19 | 2007-02-13 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
US8372016B2 (en) | 2002-04-19 | 2013-02-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling and analyte sensing |
US7297122B2 (en) | 2002-04-19 | 2007-11-20 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7901362B2 (en) | 2002-04-19 | 2011-03-08 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7368190B2 (en) * | 2002-05-02 | 2008-05-06 | Abbott Diabetes Care Inc. | Miniature biological fuel cell that is operational under physiological conditions, and associated devices and methods |
US7560239B2 (en) * | 2002-06-04 | 2009-07-14 | Lin-Zhi International Inc. | Homogeneous enzyme immunoassay for simultaneous detection of multiple analytes |
EP1560930A4 (en) * | 2002-11-15 | 2007-05-16 | Applera Corp | Nucleic acid sequence detection |
US8574895B2 (en) | 2002-12-30 | 2013-11-05 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus using optical techniques to measure analyte levels |
US7914655B2 (en) * | 2003-05-13 | 2011-03-29 | Siemens Aktiengesellschaft | Potentiostatic circuit arrangement on a biosensor for digitisation of the measured current |
ES2347248T3 (en) | 2003-05-30 | 2010-10-27 | Pelikan Technologies Inc. | PROCEDURE AND APPLIANCE FOR FLUID INJECTION. |
US7850621B2 (en) | 2003-06-06 | 2010-12-14 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
WO2006001797A1 (en) | 2004-06-14 | 2006-01-05 | Pelikan Technologies, Inc. | Low pain penetrating |
ES2657627T3 (en) * | 2003-06-20 | 2018-03-06 | F. Hoffmann-La Roche Ag | Electrochemical biosensors |
CA2529378C (en) | 2003-06-20 | 2014-04-15 | F.Hoffmann-La Roche Ag | Method and reagent for producing narrow, homogenous reagent strips |
CA2530211C (en) * | 2003-07-01 | 2011-10-04 | Eric R. Diebold | Electrochemical affinity biosensor system and methods |
EP1671096A4 (en) | 2003-09-29 | 2009-09-16 | Pelikan Technologies Inc | Method and apparatus for an improved sample capture device |
WO2005037095A1 (en) | 2003-10-14 | 2005-04-28 | Pelikan Technologies, Inc. | Method and apparatus for a variable user interface |
WO2005065192A2 (en) * | 2003-12-29 | 2005-07-21 | The Trustees Of Columbia University In The City Of New York | Photolabile compounds |
US8668656B2 (en) | 2003-12-31 | 2014-03-11 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for improving fluidic flow and sample capture |
US7822454B1 (en) | 2005-01-03 | 2010-10-26 | Pelikan Technologies, Inc. | Fluid sampling device with improved analyte detecting member configuration |
US8758593B2 (en) * | 2004-01-08 | 2014-06-24 | Schlumberger Technology Corporation | Electrochemical sensor |
GB2409902B (en) * | 2004-01-08 | 2006-04-19 | Schlumberger Holdings | Electro-chemical sensor |
US7510849B2 (en) * | 2004-01-29 | 2009-03-31 | Glucolight Corporation | OCT based method for diagnosis and therapy |
WO2005078118A1 (en) * | 2004-02-06 | 2005-08-25 | Bayer Healthcare Llc | Oxidizable species as an internal reference for biosensors and method of use |
EP1751546A2 (en) | 2004-05-20 | 2007-02-14 | Albatros Technologies GmbH & Co. KG | Printable hydrogel for biosensors |
KR101330785B1 (en) * | 2004-05-21 | 2013-11-18 | 아가매트릭스, 인코포레이티드 | Electrochemical cell and method of making an electrochemical cell |
US9775553B2 (en) | 2004-06-03 | 2017-10-03 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a fluid sampling device |
WO2005120365A1 (en) | 2004-06-03 | 2005-12-22 | Pelikan Technologies, Inc. | Method and apparatus for a fluid sampling device |
US7511142B2 (en) * | 2004-07-28 | 2009-03-31 | Agency For Science, Technology And Research | Mediator-modified redox biomolecules for use in electrochemical determination of analyte |
US7254429B2 (en) * | 2004-08-11 | 2007-08-07 | Glucolight Corporation | Method and apparatus for monitoring glucose levels in a biological tissue |
US8036727B2 (en) | 2004-08-11 | 2011-10-11 | Glt Acquisition Corp. | Methods for noninvasively measuring analyte levels in a subject |
US20060054274A1 (en) * | 2004-09-16 | 2006-03-16 | Yaw-Huei Tsai | Method for manufacturing optical filter |
US7709149B2 (en) * | 2004-09-24 | 2010-05-04 | Lg Chem, Ltd. | Composite precursor for aluminum-containing lithium transition metal oxide and process for preparation of the same |
US8652831B2 (en) | 2004-12-30 | 2014-02-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for analyte measurement test time |
WO2006110859A2 (en) | 2005-04-13 | 2006-10-19 | Glucolight Corporation | Method for data reduction and calibration of an oct-based blood glucose monitor |
EP1813937A1 (en) * | 2006-01-25 | 2007-08-01 | Roche Diagnostics GmbH | Electrochemical biosensor analysis system |
US7885698B2 (en) | 2006-02-28 | 2011-02-08 | Abbott Diabetes Care Inc. | Method and system for providing continuous calibration of implantable analyte sensors |
US7909983B2 (en) * | 2006-05-04 | 2011-03-22 | Nipro Diagnostics, Inc. | System and methods for automatically recognizing a control solution |
WO2008007277A2 (en) * | 2006-06-27 | 2008-01-17 | Agamatrix, Inc. | Detection of analytes in a dual-mediator electrochemical test strip |
US7699973B2 (en) * | 2006-06-30 | 2010-04-20 | Abbott Diabetes Care Inc. | Rapid analyte measurement assay |
EP2097750A2 (en) * | 2006-10-26 | 2009-09-09 | Abbott Laboratories | Immunoassay of analytes in samples containing endogenous anti-analyte antibodies |
US20080305512A1 (en) * | 2006-10-26 | 2008-12-11 | Mattingly Phillip G | Assay for cardiac troponin autoantibodies |
US7776605B2 (en) | 2006-10-26 | 2010-08-17 | Abbott Laboratories | Assay for cardiac troponin autoantibodies |
US8079955B2 (en) * | 2006-11-28 | 2011-12-20 | Isense Corporation | Method and apparatus for managing glucose control |
US7914999B2 (en) | 2006-12-29 | 2011-03-29 | Abbott Laboratories | Non-denaturing lysis reagent |
JP2010514450A (en) * | 2006-12-29 | 2010-05-06 | アプライド バイオシステムズ インコーポレイテッド | Nucleic acid detection method and system |
EP2118657B1 (en) | 2006-12-29 | 2014-05-21 | Abbott Laboratories | Non-denaturing lysis reagent for use with capture-in-solution immunoassay |
US8709709B2 (en) | 2007-05-18 | 2014-04-29 | Luoxis Diagnostics, Inc. | Measurement and uses of oxidative status |
JP5330381B2 (en) * | 2007-05-18 | 2013-10-30 | インスティチュート フォー モレキュラー メディスン インコーポレイテッド | Method for measuring and using redox potential (ORP) |
JP2010528297A (en) | 2007-05-23 | 2010-08-19 | アリゾナ ボード オブ リージェンツ フォー アンド オン ビハーフ オブ アリゾナ ステイト ユニバーシティ | System and method for integrated electrochemical detection and electrical detection |
US8197650B2 (en) * | 2007-06-07 | 2012-06-12 | Sensor Innovations, Inc. | Silicon electrochemical sensors |
WO2009015077A1 (en) * | 2007-07-23 | 2009-01-29 | Agamatrix, Inc. | Electrochemical test strip |
US8571617B2 (en) | 2008-03-04 | 2013-10-29 | Glt Acquisition Corp. | Flowometry in optical coherence tomography for analyte level estimation |
US8008037B2 (en) | 2008-03-27 | 2011-08-30 | Roche Diagnostics Operations, Inc. | Matrix composition with alkylphenazine quaternary salt and a nitrosoaniline |
US8492158B2 (en) * | 2008-03-31 | 2013-07-23 | Applied Biosystems, Llc | Electrochemical labels derived from siderophores |
WO2009126900A1 (en) | 2008-04-11 | 2009-10-15 | Pelikan Technologies, Inc. | Method and apparatus for analyte detecting device |
US9169320B2 (en) * | 2008-12-11 | 2015-10-27 | Sekisui Medical Co., Ltd. | Antibody to N-terminal region of hemoglobin β-chain |
US9341633B2 (en) * | 2008-12-11 | 2016-05-17 | Sekisui Medical Co., Ltd. | Method for pre-treating sample containing glycated hemoglobin |
US9375169B2 (en) | 2009-01-30 | 2016-06-28 | Sanofi-Aventis Deutschland Gmbh | Cam drive for managing disposable penetrating member actions with a single motor and motor and control system |
US20100213057A1 (en) | 2009-02-26 | 2010-08-26 | Benjamin Feldman | Self-Powered Analyte Sensor |
EP2440911A4 (en) * | 2009-06-08 | 2013-02-13 | Univ Western Ontario | An electrochemical method and apparatus of identifying the presence of a target |
US8652788B2 (en) | 2009-12-02 | 2014-02-18 | Abbott Laboratories | Assay for diagnosis of cardiac myocyte damage |
US8835120B2 (en) | 2009-12-02 | 2014-09-16 | Abbott Laboratories | Assay for cardiac troponin-T (cTnT) |
US8183002B2 (en) | 2009-12-03 | 2012-05-22 | Abbott Laboratories | Autoantibody enhanced immunoassays and kits |
US20110136141A1 (en) * | 2009-12-03 | 2011-06-09 | Abbott Laboratories | Peptide reagents and method for inhibiting autoantibody antigen binding |
CN103069277B (en) * | 2010-03-31 | 2016-03-30 | 积水医疗株式会社 | Utilize the determination method of immunochromatography, immune chromatograph test-strips and the mensuration kit for immunochromatography |
US8965476B2 (en) | 2010-04-16 | 2015-02-24 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8956859B1 (en) | 2010-08-13 | 2015-02-17 | Aviex Technologies Llc | Compositions and methods for determining successful immunization by one or more vaccines |
AU2011338255B2 (en) * | 2010-12-09 | 2016-06-02 | Abbott Diabetes Care Inc. | Analyte sensors with a sensing surface having small sensing spots |
WO2012083258A2 (en) | 2010-12-16 | 2012-06-21 | Sensor Innovations, Inc. | Electrochemical sensors |
MX2013004852A (en) | 2011-02-28 | 2013-10-01 | Luoxis Diagnostics Inc | Method and apparatus for measuring oxidation-reduction potential. |
US20140170068A1 (en) | 2011-03-11 | 2014-06-19 | Board Of Regents Of The University Of Nebraska | Biomarker for coronary artery disease |
DE102011108885A1 (en) * | 2011-07-28 | 2013-01-31 | Forschungszentrum Jülich GmbH | Electrode arrangement and method for operating the electrode arrangement |
AU2012304200A1 (en) * | 2011-09-01 | 2013-05-02 | Newsouth Innovations Pty Limited | Electrochemical competition sensor |
AU2012304199B2 (en) * | 2011-09-01 | 2015-10-01 | Newsouth Innovations Pty Limited | Electrochemical affinity sensor |
KR20150013146A (en) | 2012-04-19 | 2015-02-04 | 로익스 다이어그노스틱스, 아이엔씨. | Multiple layer gel |
IN2015DN01707A (en) | 2012-10-23 | 2015-05-22 | Luoxis Diagnostics Inc | |
US9458488B2 (en) | 2013-03-15 | 2016-10-04 | Nanomix, Inc. | Point of care sensor systems |
CN103205135B (en) * | 2013-04-25 | 2015-10-28 | 大连理工大学 | Photosensitive dye osmium complex and preparation method thereof, carcinogenesis DNA oxidative damage quick detection kit and detection method |
US10006881B2 (en) * | 2013-06-03 | 2018-06-26 | Life Safety Distribution Ag | Microelectrodes for electrochemical gas detectors |
RU2698311C2 (en) * | 2014-03-20 | 2019-08-26 | Байо-Ред Лабораториз, Инк. | Analysis for glycated proteins |
US11009479B2 (en) | 2014-05-27 | 2021-05-18 | Case Western Reserve University | Systems and methods for the detection of HbA1c |
JP6576170B2 (en) | 2015-09-02 | 2019-09-18 | 旭化成ファーマ株式会社 | Method for measuring glycated protein using comb electrode |
US20210102913A1 (en) * | 2017-03-29 | 2021-04-08 | Case Western Reserve University | Compositions and methods of detecting 17 beta-estradiol |
CN108061777B (en) * | 2017-11-27 | 2020-05-08 | 浙江公正检验中心有限公司 | Method for detecting residual quantity of 34 illegally added medicines in weight-losing health-care food |
US11697807B2 (en) | 2019-09-30 | 2023-07-11 | Case Western Reserve University | Electrochemical biosensor |
CN115215953B (en) * | 2022-07-15 | 2023-10-24 | 江西司托迈医疗科技有限公司 | Self-assembled redox polymers, sensors and methods of making the same |
Family Cites Families (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2058839B (en) | 1979-09-08 | 1983-02-16 | Engelhard Min & Chem | Photo electrochemical processes |
US4323536A (en) | 1980-02-06 | 1982-04-06 | Eastman Kodak Company | Multi-analyte test device |
US4293310A (en) | 1980-03-14 | 1981-10-06 | University Of Pittsburgh | Photoelectrochemical immunoassay |
DE3278334D1 (en) | 1981-10-23 | 1988-05-19 | Genetics Int Inc | Sensor for components of a liquid mixture |
US4478744A (en) * | 1982-01-25 | 1984-10-23 | Sherwood Medical Company | Method of obtaining antibodies |
DE3221339A1 (en) | 1982-06-05 | 1983-12-08 | Basf Ag, 6700 Ludwigshafen | METHOD FOR THE ELECTROCHEMICAL HYDRATION OF NICOTINAMIDADENINE-DINUCLEOTIDE |
CA1219040A (en) | 1983-05-05 | 1987-03-10 | Elliot V. Plotkin | Measurement of enzyme-catalysed reactions |
CA1226036A (en) | 1983-05-05 | 1987-08-25 | Irving J. Higgins | Analytical equipment and sensor electrodes therefor |
CA1220818A (en) | 1983-05-05 | 1987-04-21 | Hugh A.O. Hill | Assay techniques utilising specific binding agents |
GB8328520D0 (en) | 1983-10-25 | 1983-11-23 | Serono Diagnostics Ltd | Methods of assay |
GB8402058D0 (en) | 1984-01-26 | 1984-02-29 | Serono Diagnostics Ltd | Methods of assay |
US5141868A (en) | 1984-06-13 | 1992-08-25 | Internationale Octrooi Maatschappij "Octropa" Bv | Device for use in chemical test procedures |
GB8417301D0 (en) | 1984-07-06 | 1984-08-08 | Serono Diagnostics Ltd | Assay |
US5238808A (en) * | 1984-10-31 | 1993-08-24 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
GB8432069D0 (en) | 1984-12-19 | 1985-01-30 | Iq Bio Ltd | Apparatus for immunoassay |
GB8504522D0 (en) | 1985-02-21 | 1985-03-27 | Genetics Int Inc | Electrochemistry of mediators |
AU599916B2 (en) | 1985-06-12 | 1990-08-02 | Ferdinard Lincoln Vogel | Tilt sail boat |
US4830959A (en) | 1985-11-11 | 1989-05-16 | Medisense, Inc. | Electrochemical enzymic assay procedures |
US4963245A (en) | 1986-05-02 | 1990-10-16 | Ciba Corning Diagnostics Corp. | Unitary multiple electrode sensor |
US4900405A (en) | 1987-07-15 | 1990-02-13 | Sri International | Surface type microelectronic gas and vapor sensor |
US4832814A (en) | 1987-12-28 | 1989-05-23 | E. I. Du Pont De Nemours And Company | Electrofusion cell and method of making the same |
JP2638877B2 (en) | 1988-02-10 | 1997-08-06 | 日本電気株式会社 | Immunochemical assay |
DE68924026T3 (en) | 1988-03-31 | 2008-01-10 | Matsushita Electric Industrial Co., Ltd., Kadoma | BIOSENSOR AND ITS MANUFACTURE. |
US4954414A (en) | 1988-11-08 | 1990-09-04 | The Mead Corporation | Photosensitive composition containing a transition metal coordination complex cation and a borate anion and photosensitive materials employing the same |
US5312762A (en) | 1989-03-13 | 1994-05-17 | Guiseppi Elie Anthony | Method of measuring an analyte by measuring electrical resistance of a polymer film reacting with the analyte |
US5198367A (en) | 1989-06-09 | 1993-03-30 | Masuo Aizawa | Homogeneous amperometric immunoassay |
US5491097A (en) | 1989-06-15 | 1996-02-13 | Biocircuits Corporation | Analyte detection with multilayered bioelectronic conductivity sensors |
DE69025134T2 (en) | 1989-11-24 | 1996-08-14 | Matsushita Electric Ind Co Ltd | Method of manufacturing a biosensor |
KR0171222B1 (en) | 1989-12-15 | 1999-02-18 | 스티브 올드함 | Redox mediator reagent and biosensor |
US5243516A (en) | 1989-12-15 | 1993-09-07 | Boehringer Mannheim Corporation | Biosensing instrument and method |
US4999632A (en) | 1989-12-15 | 1991-03-12 | Boehringer Mannheim Corporation | Analog to digital conversion with noise reduction |
WO1991016630A1 (en) | 1990-04-12 | 1991-10-31 | Optical Systems Development Partners | Device and method for electroimmunoassay |
FR2673289B1 (en) | 1991-02-21 | 1994-06-17 | Asulab Sa | SENSOR FOR MEASURING THE QUANTITY OF A COMPONENT IN SOLUTION. |
FR2673183B1 (en) | 1991-02-21 | 1996-09-27 | Asulab Sa | MONO, BIS OR TRIS (2,2'-BIPYRIDINE SUBSTITUTED) COMPLEXES OF A SELECTED METAL AMONG IRON, RUTHENIUM, OSMIUM OR VANADIUM AND THEIR PREPARATION PROCESSES. |
US5192415A (en) | 1991-03-04 | 1993-03-09 | Matsushita Electric Industrial Co., Ltd. | Biosensor utilizing enzyme and a method for producing the same |
US5264103A (en) | 1991-10-18 | 1993-11-23 | Matsushita Electric Industrial Co., Ltd. | Biosensor and a method for measuring a concentration of a substrate in a sample |
FR2692357A1 (en) | 1992-06-12 | 1993-12-17 | Centre Nat Rech Scient | Redox-labeled antigen, immunoassay method with electrochemical detection and assay kit. |
GB9225354D0 (en) * | 1992-12-04 | 1993-01-27 | Univ Manchester | Immunoassay |
JPH07508537A (en) * | 1993-04-21 | 1995-09-21 | イーストマン コダック カンパニー | ion sensitive compounds |
DE4318519C2 (en) * | 1993-06-03 | 1996-11-28 | Fraunhofer Ges Forschung | Electrochemical sensor |
US5366609A (en) | 1993-06-08 | 1994-11-22 | Boehringer Mannheim Corporation | Biosensing meter with pluggable memory key |
US5405511A (en) | 1993-06-08 | 1995-04-11 | Boehringer Mannheim Corporation | Biosensing meter with ambient temperature estimation method and system |
US5352351A (en) | 1993-06-08 | 1994-10-04 | Boehringer Mannheim Corporation | Biosensing meter with fail/safe procedures to prevent erroneous indications |
EP0702789B8 (en) | 1993-06-08 | 2006-06-14 | Roche Diagnostics Operations, Inc. | Biosensing meter which detects proper electrode engagement and distinguishes sample and check strips |
US5427912A (en) | 1993-08-27 | 1995-06-27 | Boehringer Mannheim Corporation | Electrochemical enzymatic complementation immunoassay |
US5437772A (en) | 1993-11-01 | 1995-08-01 | The Electrosynthesis Co., Inc. | Portable lead detector |
DE4344646A1 (en) * | 1993-12-24 | 1995-06-29 | Frieder Prof Dr Scheller | Device for a competitive immuno-assay for the detection of hapten(s) |
US5589326A (en) | 1993-12-30 | 1996-12-31 | Boehringer Mannheim Corporation | Osmium-containing redox mediator |
US5643721A (en) * | 1994-02-09 | 1997-07-01 | Abbott Laboratories | Bioreagent immobilization medium |
US5710009A (en) | 1994-02-17 | 1998-01-20 | Serex, Inc. | Receptor:release ligand (reland) complexes and release assays using said reland and methods and kits based thereon |
US5437999A (en) | 1994-02-22 | 1995-08-01 | Boehringer Mannheim Corporation | Electrochemical sensor |
JP3027306B2 (en) | 1994-06-02 | 2000-04-04 | 松下電器産業株式会社 | Biosensor and manufacturing method thereof |
AU6476696A (en) * | 1995-06-07 | 1996-12-30 | Igen, Inc. | Simultaneous assay method using lanthanide chelates as the l uminophore for multiple labels |
US5701373A (en) | 1995-10-12 | 1997-12-23 | Sdl, Inc. | Method for improving the coupling efficiency of elliptical light beams into optical waveguides |
DE19608493A1 (en) | 1996-03-05 | 1997-09-11 | Basf Ag | Precious metal-free catalyst composition for the production of hydrogen peroxide |
WO1997032886A1 (en) * | 1996-03-06 | 1997-09-12 | Igen International, Inc. | Ecl labels having improved nsb properties |
DE19610115C2 (en) | 1996-03-14 | 2000-11-23 | Fraunhofer Ges Forschung | Detection of molecules and molecular complexes |
US5958791A (en) * | 1996-09-27 | 1999-09-28 | Innovative Biotechnologies, Inc. | Interdigitated electrode arrays for liposome-enhanced immunoassay and test device |
US6054039A (en) * | 1997-08-18 | 2000-04-25 | Shieh; Paul | Determination of glycoprotein and glycosylated hemoglobin in blood |
US6174734B1 (en) * | 1997-10-24 | 2001-01-16 | Abbott Laboratories | Measurement of glycated hemoglobin |
-
1999
- 1999-05-28 WO PCT/US1999/011891 patent/WO1999062919A1/en active IP Right Grant
- 1999-05-28 AT AT99926004T patent/ATE222915T1/en not_active IP Right Cessation
- 1999-05-28 US US09/322,791 patent/US6352824B1/en not_active Expired - Lifetime
- 1999-05-28 AT AT99925981T patent/ATE221076T1/en active
- 1999-05-28 WO PCT/US1999/011850 patent/WO1999063346A1/en active IP Right Grant
- 1999-05-28 US US09/322,500 patent/US6262264B1/en not_active Expired - Lifetime
- 1999-05-28 ES ES99926004T patent/ES2182530T3/en not_active Expired - Lifetime
- 1999-05-28 DE DE69902662T patent/DE69902662T2/en not_active Expired - Lifetime
- 1999-05-28 EP EP99926004A patent/EP1084133B1/en not_active Expired - Lifetime
- 1999-05-28 AU AU42157/99A patent/AU4215799A/en not_active Abandoned
- 1999-05-28 AT AT99925979T patent/ATE266868T1/en not_active IP Right Cessation
- 1999-05-28 WO PCT/US1999/011855 patent/WO1999062918A1/en active IP Right Grant
- 1999-05-28 CA CA002333732A patent/CA2333732C/en not_active Expired - Fee Related
- 1999-05-28 DE DE69902265T patent/DE69902265T2/en not_active Expired - Lifetime
- 1999-05-28 ES ES99925979T patent/ES2220066T3/en not_active Expired - Lifetime
- 1999-05-28 US US09/330,422 patent/US6294062B1/en not_active Ceased
- 1999-05-28 EP EP99925979A patent/EP1084409B1/en not_active Expired - Lifetime
- 1999-05-28 DE DE69917258T patent/DE69917258T2/en not_active Expired - Lifetime
- 1999-05-28 EP EP99925981A patent/EP1084132B1/en not_active Expired - Lifetime
- 1999-05-28 AU AU42159/99A patent/AU4215999A/en not_active Abandoned
- 1999-05-28 AU AU42178/99A patent/AU4217899A/en not_active Abandoned
- 1999-05-28 CA CA002333686A patent/CA2333686C/en not_active Expired - Fee Related
- 1999-05-28 CA CA002333875A patent/CA2333875C/en not_active Expired - Fee Related
- 1999-05-28 ES ES99925981T patent/ES2179660T3/en not_active Expired - Lifetime
-
2001
- 2001-11-01 US US09/999,110 patent/US7045310B2/en not_active Expired - Fee Related
-
2003
- 2003-09-25 US US10/671,436 patent/USRE40198E1/en not_active Expired - Lifetime
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2333875A1 (en) | Redox reversible bipyridyl osmium complex conjugates | |
WO1991012023A3 (en) | Hybrid reagents capable of selectively releasing molecules into cells | |
CA2305415A1 (en) | Extended dynamic range assays | |
AU1602601A (en) | Polymeric transition metal complexes and uses thereof | |
NO954441D0 (en) | Tricyclopolyazamacrocyclophosphonic acids, complexes and derivatives thereof for use as contrast agents | |
CA2318161A1 (en) | Microfabricated aperture-based sensor | |
NO301829B1 (en) | 2-pyridylmethylene polyazamacrocyclophosphonic acids, complexes and pharmaceutical preparations based on these | |
WO1989003041A3 (en) | Tridentate conjugate and method of use thereof | |
DE60030274D1 (en) | WHOLE VACCINE VACCINE CONTAINING STAPHYLOCOCCUS AUREUS ANTIGEN | |
EP0165726A3 (en) | Intestinal microflora-improving agent | |
HK1041277A1 (en) | Polymer combining with phosphoric acid and preparation containing the same. | |
HK1033582A1 (en) | Antibodies to death receptor 4 (dr4) and uses thereof | |
CA2297216A1 (en) | Cyanine dyes | |
AU8097491A (en) | Benzoic acid substituted derivatives having cardiovascular activity | |
CA2270964A1 (en) | Benzonaphthyridines as bronchial therapeutics | |
AU5076799A (en) | Trifunctional reagent for conjugation to a biomolecule | |
CA2067250A1 (en) | Inhibition of padgem-mediated cell binding | |
FR2666803B1 (en) | SOLID GLASS COMPOSITIONS BASED ON LI3PO4 AND LIPO3, AND ELECTROCHEMICAL CELLS USING THE SAME. | |
EP0967692A3 (en) | Connector and connector attachment structure | |
EP0227450A3 (en) | Substituted 5,6-dialkoxyquinazoline derivatives | |
CA2295321A1 (en) | Isolated nona- and decapeptides which bind to hla molecules, and the use thereof | |
WO2000000599A3 (en) | Composition for the induction of apoptosis in target cells | |
YU12397A (en) | NOVEL PYRIMIDO [1,2-a] INDOLES | |
CA2360762A1 (en) | Sebocytes, sebocyte cell lines and applications thereof | |
EP0227451A3 (en) | 5,6-dialkoxy-4-imino-2 (1h)quinazolinone derivatives |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |