CA2330136A1 - Apparatus and method for vascular embolization - Google Patents

Apparatus and method for vascular embolization Download PDF

Info

Publication number
CA2330136A1
CA2330136A1 CA002330136A CA2330136A CA2330136A1 CA 2330136 A1 CA2330136 A1 CA 2330136A1 CA 002330136 A CA002330136 A CA 002330136A CA 2330136 A CA2330136 A CA 2330136A CA 2330136 A1 CA2330136 A1 CA 2330136A1
Authority
CA
Canada
Prior art keywords
embolic device
microcatheter
aneurysm
rigid
embolic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002330136A
Other languages
French (fr)
Other versions
CA2330136C (en
Inventor
Robert F. Rosenbluth
Brian J. Cox
George R. Greene, Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MicroVention Inc
Original Assignee
Microvention, Inc.
Robert F. Rosenbluth
Brian J. Cox
George R. Greene, Jr.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microvention, Inc., Robert F. Rosenbluth, Brian J. Cox, George R. Greene, Jr. filed Critical Microvention, Inc.
Priority to CA2647850A priority Critical patent/CA2647850C/en
Publication of CA2330136A1 publication Critical patent/CA2330136A1/en
Application granted granted Critical
Publication of CA2330136C publication Critical patent/CA2330136C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
    • A61B17/12113—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/1214—Coils or wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12163—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a string of elements connected to each other
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
    • A61B17/12186—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices liquid materials adapted to be injected
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
    • A61B17/12195—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices comprising a curable material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B2017/1205—Introduction devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B2017/1205—Introduction devices
    • A61B2017/12054—Details concerning the detachment of the occluding device from the introduction device
    • A61B2017/12063—Details concerning the detachment of the occluding device from the introduction device electrolytically detachable

Landscapes

  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Reproductive Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Surgical Instruments (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Apparatus for vascular embolization, deployable through a microt--catheter, includes a flexible, elongate deployment tube dimensioned for insertion through the microcatheter, and a filamentous embolic device releasably attached to the distal end of the tube. The embolic device is controllably transformable from a soft, compliant state to a rigid or semi-rigid state. The embolic de-vice may include a polymeric material that is transformable by contact with vascular blood or with a liquid that is cooler than vascular blood, or it may include a metallic material that is transformable by electrolytic corrosion.
The embolic device may be a continuous filamentous polymeric extrusion; an elon-gate microcoil filled with polymeric material; an elongate, multi-segmented chain including polymeric interconnecting portions; or an elongate chain of metal segments that are fused together by electrolytic corrosion. An aneurysm is embolized with this apparatus by deploying a microcatheter so that its distal end is adjacent the aneurysm; deploying the embolic device through the microcatheter and into the aneurysm so that the embolic device forms a web-like mass in the aneurysm; and transforming the embolic device from its soft, compliant state to its rigid or semi-rigid state. The embolic device is advantageously deployed by releasably attaching it to a flexible, elongate deployment tube that is passed through the microcatheter, and then detaching the embolic device from the tube when the embolic device is suitably situated.
CA002330136A 1998-04-28 1999-04-23 Apparatus and method for vascular embolization Expired - Fee Related CA2330136C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2647850A CA2647850C (en) 1998-04-28 1999-04-23 Apparatus and method for vascular embolization

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/069,008 1998-04-28
US09/069,008 US6015424A (en) 1998-04-28 1998-04-28 Apparatus and method for vascular embolization
PCT/US1999/007399 WO1999055239A1 (en) 1998-04-28 1999-04-23 Apparatus and method for vascular embolization

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2647850A Division CA2647850C (en) 1998-04-28 1999-04-23 Apparatus and method for vascular embolization

Publications (2)

Publication Number Publication Date
CA2330136A1 true CA2330136A1 (en) 1999-11-04
CA2330136C CA2330136C (en) 2009-02-17

Family

ID=22086109

Family Applications (3)

Application Number Title Priority Date Filing Date
CA2736639A Abandoned CA2736639A1 (en) 1998-04-28 1999-04-23 Apparatus and method for vascular embolization
CA002330136A Expired - Fee Related CA2330136C (en) 1998-04-28 1999-04-23 Apparatus and method for vascular embolization
CA2647850A Expired - Fee Related CA2647850C (en) 1998-04-28 1999-04-23 Apparatus and method for vascular embolization

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA2736639A Abandoned CA2736639A1 (en) 1998-04-28 1999-04-23 Apparatus and method for vascular embolization

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2647850A Expired - Fee Related CA2647850C (en) 1998-04-28 1999-04-23 Apparatus and method for vascular embolization

Country Status (11)

Country Link
US (2) US6015424A (en)
EP (3) EP1518502B1 (en)
JP (2) JP4376458B2 (en)
CN (1) CN1200648C (en)
AT (2) ATE359031T1 (en)
AU (4) AU764797C (en)
BR (1) BR9910027A (en)
CA (3) CA2736639A1 (en)
DE (2) DE69921979T2 (en)
ES (3) ES2232136T3 (en)
WO (1) WO1999055239A1 (en)

Families Citing this family (209)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5871537A (en) * 1996-02-13 1999-02-16 Scimed Life Systems, Inc. Endovascular apparatus
US6146373A (en) * 1997-10-17 2000-11-14 Micro Therapeutics, Inc. Catheter system and method for injection of a liquid embolic composition and a solidification agent
US6511468B1 (en) * 1997-10-17 2003-01-28 Micro Therapeutics, Inc. Device and method for controlling injection of liquid embolic composition
US7070607B2 (en) * 1998-01-27 2006-07-04 The Regents Of The University Of California Bioabsorbable polymeric implants and a method of using the same to create occlusions
US6113629A (en) * 1998-05-01 2000-09-05 Micrus Corporation Hydrogel for the therapeutic treatment of aneurysms
DK173411B2 (en) * 1998-06-19 2007-04-16 Coloplast As Collection bag for human body secretions
US6051607A (en) * 1998-07-02 2000-04-18 Micro Therapeutics, Inc. Vascular embolizing compositions comprising ethyl lactate and methods for their use
US6165193A (en) * 1998-07-06 2000-12-26 Microvention, Inc. Vascular embolization with an expansible implant
US7410482B2 (en) * 1998-09-04 2008-08-12 Boston Scientific-Scimed, Inc. Detachable aneurysm neck bridge
CA2323151C (en) * 1999-01-27 2007-04-10 Regents Of The University Of California Biodegradable polymer/protein based coils for intralumenal implants
US7018401B1 (en) 1999-02-01 2006-03-28 Board Of Regents, The University Of Texas System Woven intravascular devices and methods for making the same and apparatus for delivery of the same
EP2319455A3 (en) * 1999-06-02 2012-04-18 Microtransform, Inc. Intracorporeal occlusive device
US6312421B1 (en) 1999-07-23 2001-11-06 Neurovasx, Inc. Aneurysm embolization material and device
US6602261B2 (en) 1999-10-04 2003-08-05 Microvention, Inc. Filamentous embolic device with expansile elements
US6544225B1 (en) * 2000-02-29 2003-04-08 Cordis Neurovascular, Inc. Embolic coil hydraulic deployment system with purge mechanism
US6514264B1 (en) * 2000-06-01 2003-02-04 Cordis Neurovascular, Inc. Embolic coil hydraulic deployment system with purge mechanism
US6530934B1 (en) * 2000-06-06 2003-03-11 Sarcos Lc Embolic device composed of a linear sequence of miniature beads
US6355275B1 (en) 2000-06-23 2002-03-12 Carbon Medical Technologies, Inc. Embolization using carbon coated microparticles
EP1169969A1 (en) * 2000-07-05 2002-01-09 Medtronic Ave, Inc. Pedicle occlusion device
KR100387384B1 (en) * 2000-07-26 2003-06-12 규 호 이 Embolic material detachment detection system and method and assembly for embolic treatments
US6855154B2 (en) 2000-08-11 2005-02-15 University Of Louisville Research Foundation, Inc. Endovascular aneurysm treatment device and method
US6394965B1 (en) 2000-08-15 2002-05-28 Carbon Medical Technologies, Inc. Tissue marking using biocompatible microparticles
US20040266983A1 (en) * 2000-08-17 2004-12-30 Reeve Lorraine E Purified polyoxyalkylene block copolymers
US8313504B2 (en) 2000-09-18 2012-11-20 Cordis Corporation Foam matrix embolization device
US6723108B1 (en) * 2000-09-18 2004-04-20 Cordis Neurovascular, Inc Foam matrix embolization device
US6605101B1 (en) 2000-09-26 2003-08-12 Microvention, Inc. Microcoil vaso-occlusive device with multi-axis secondary configuration
US7029486B2 (en) * 2000-09-26 2006-04-18 Microvention, Inc. Microcoil vaso-occlusive device with multi-axis secondary configuration
US7033374B2 (en) * 2000-09-26 2006-04-25 Microvention, Inc. Microcoil vaso-occlusive device with multi-axis secondary configuration
US6689141B2 (en) 2000-10-18 2004-02-10 Microvention, Inc. Mechanism for the deployment of endovascular implants
US20040204701A1 (en) * 2000-10-18 2004-10-14 Brian Cox Mechanism for the deployment of endovascular implants
US6607538B1 (en) 2000-10-18 2003-08-19 Microvention, Inc. Mechanism for the deployment of endovascular implants
US6602269B2 (en) 2001-03-30 2003-08-05 Scimed Life Systems Embolic devices capable of in-situ reinforcement
US20020165582A1 (en) * 2001-04-26 2002-11-07 Porter Christopher H. Method and apparatus for delivering materials to the body
EP1392182A1 (en) * 2001-05-04 2004-03-03 Concentric Medical Hydrogel vaso-occlusive device
AU2002340749A1 (en) * 2001-05-04 2002-11-18 Concentric Medical Coated combination vaso-occlusive device
WO2002089676A2 (en) * 2001-05-04 2002-11-14 Concentric Medical Hydrogel filament vaso-occlusive device
US6607539B1 (en) * 2001-05-18 2003-08-19 Endovascular Technologies, Inc. Electric endovascular implant depolyment system
ATE516759T1 (en) 2001-05-29 2011-08-15 Microvention Inc METHOD FOR PRODUCING EXPANDABLE FILAMENTOUS EMBOLIZATION DEVICES
US7687053B2 (en) * 2001-08-20 2010-03-30 Boston Scientific Scimed, Inc. Embolic compositions with non-cyanoacrylate rheology modifying agents
US20030050635A1 (en) * 2001-08-22 2003-03-13 Csaba Truckai Embolization systems and techniques for treating tumors
US20030093111A1 (en) * 2001-10-26 2003-05-15 Concentric Medical Device for vaso-occlusion and interventional therapy
WO2003039376A1 (en) 2001-11-07 2003-05-15 Microvention, Inc. Microcoil vaso-occlusive device with multi-axis secondary configuration
US20060292206A1 (en) 2001-11-26 2006-12-28 Kim Steven W Devices and methods for treatment of vascular aneurysms
US20030199887A1 (en) * 2002-04-23 2003-10-23 David Ferrera Filamentous embolization device and method of use
US7048719B1 (en) 2002-06-07 2006-05-23 Microvention, Inc. Endovascular catheter resheathing apparatus and related methods
US8425549B2 (en) 2002-07-23 2013-04-23 Reverse Medical Corporation Systems and methods for removing obstructive matter from body lumens and treating vascular defects
US20050171572A1 (en) 2002-07-31 2005-08-04 Microvention, Inc. Multi-layer coaxial vaso-occlusive device
US8273100B2 (en) * 2002-07-31 2012-09-25 Microvention, Inc. Three element coaxial vaso-occlusive device
US7481821B2 (en) 2002-11-12 2009-01-27 Thomas J. Fogarty Embolization device and a method of using the same
US20040115164A1 (en) * 2002-12-17 2004-06-17 Pierce Ryan K. Soft filament occlusive device delivery system
US20050043585A1 (en) * 2003-01-03 2005-02-24 Arindam Datta Reticulated elastomeric matrices, their manufacture and use in implantable devices
US7229454B2 (en) * 2003-01-07 2007-06-12 Boston Scientific Scimed, Inc. Occlusive cinching devices and methods of use
US20040260382A1 (en) 2003-02-12 2004-12-23 Fogarty Thomas J. Intravascular implants and methods of using the same
US7367989B2 (en) * 2003-02-27 2008-05-06 Scimed Life Systems, Inc. Rotating balloon expandable sheath bifurcation delivery
US7314480B2 (en) * 2003-02-27 2008-01-01 Boston Scientific Scimed, Inc. Rotating balloon expandable sheath bifurcation delivery
JP4909071B2 (en) * 2003-03-24 2012-04-04 プルーローメッド， インコーポレイテッド Temporary embolization using reverse thermosensitive polymers
ES2660627T3 (en) 2003-05-15 2018-03-23 Biomerix Corporation Crosslinked elastomeric matrices, their manufacture and their use in implantable devices
CN100400002C (en) 2003-07-03 2008-07-09 库克公司 Occluding device and method of occluding fluid flow through a body vessel
US20050015110A1 (en) * 2003-07-18 2005-01-20 Fogarty Thomas J. Embolization device and a method of using the same
US20050119687A1 (en) * 2003-09-08 2005-06-02 Dacey Ralph G.Jr. Methods of, and materials for, treating vascular defects with magnetically controllable hydrogels
US7645292B2 (en) * 2003-10-27 2010-01-12 Boston Scientific Scimed, Inc. Vaso-occlusive devices with in-situ stiffening elements
US20050090856A1 (en) * 2003-10-27 2005-04-28 Scimed Life Systems, Inc. Vasco-occlusive devices with bioactive elements
EP1689482A1 (en) * 2003-10-28 2006-08-16 Peacock, James C., III Embolic filter device and related systems and methods
WO2005046438A2 (en) * 2003-11-06 2005-05-26 Pluromed, Inc. Internal clamp for surgical procedures
US7070641B1 (en) 2003-12-03 2006-07-04 Fleetguard, Inc. Carbon media filter element
US20070104752A1 (en) * 2003-12-10 2007-05-10 Lee Jeffrey A Aneurysm embolization material and device
US20080109057A1 (en) * 2003-12-10 2008-05-08 Calabria Marie F Multiple point detacher system
US20050149108A1 (en) * 2003-12-17 2005-07-07 Microvention, Inc. Implant delivery and detachment system and method
US7294123B2 (en) * 2003-12-17 2007-11-13 Corris Neurovascular, Inc. Activatable bioactive vascular occlusive device and method of use
US7763077B2 (en) 2003-12-24 2010-07-27 Biomerix Corporation Repair of spinal annular defects and annulo-nucleoplasty regeneration
US7686841B2 (en) * 2003-12-29 2010-03-30 Boston Scientific Scimed, Inc. Rotating balloon expandable sheath bifurcation delivery system
US7922753B2 (en) * 2004-01-13 2011-04-12 Boston Scientific Scimed, Inc. Bifurcated stent delivery system
US20050165480A1 (en) * 2004-01-23 2005-07-28 Maybelle Jordan Endovascular treatment devices and methods
US8192676B2 (en) * 2004-02-12 2012-06-05 Valspar Sourcing, Inc. Container having barrier properties and method of manufacturing the same
US8012192B2 (en) 2004-02-18 2011-09-06 Boston Scientific Scimed, Inc. Multi-stent delivery system
US20070190108A1 (en) * 2004-05-17 2007-08-16 Arindam Datta High performance reticulated elastomeric matrix preparation, properties, reinforcement, and use in surgical devices, tissue augmentation and/or tissue repair
US20050267510A1 (en) * 2004-05-26 2005-12-01 Nasser Razack Device for the endovascular treatment of intracranial aneurysms
US20050273149A1 (en) * 2004-06-08 2005-12-08 Tran Thomas T Bifurcated stent delivery system
RU2383558C2 (en) * 2004-07-08 2010-03-10 Рева Медикал, Инк. Polymers with crystallising side chains for medical use
US8703113B2 (en) * 2004-07-08 2014-04-22 Reva Medical Inc. Side-chain crystallizable polymers for medical applications
CN101014642B (en) * 2004-08-13 2010-04-21 雷瓦医药公司 Inherently radiopaque bioresorbable polymers for multiple uses
US20060047299A1 (en) * 2004-08-24 2006-03-02 Ferguson Patrick J Vascular occlusive wire with extruded bioabsorbable sheath
EP1793744B1 (en) 2004-09-22 2008-12-17 Dendron GmbH Medical implant
DE502004010411D1 (en) 2004-09-22 2009-12-31 Dendron Gmbh DEVICE FOR IMPLANTING MICROWAVES
WO2006042114A1 (en) * 2004-10-06 2006-04-20 Cook, Inc. Emboli capturing device having a coil and method for capturing emboli
US7201918B2 (en) * 2004-11-16 2007-04-10 Microvention, Inc. Compositions, systems and methods for treatment of defects in blood vessels
US7413588B2 (en) * 2004-11-24 2008-08-19 Fleetguard, Inc. High efficiency, low restriction, cost effective filter
US20060116713A1 (en) * 2004-11-26 2006-06-01 Ivan Sepetka Aneurysm treatment devices and methods
US8771294B2 (en) 2004-11-26 2014-07-08 Biomerix Corporation Aneurysm treatment devices and methods
US20060116714A1 (en) * 2004-11-26 2006-06-01 Ivan Sepetka Coupling and release devices and methods for their assembly and use
US8945169B2 (en) 2005-03-15 2015-02-03 Cook Medical Technologies Llc Embolic protection device
US8221446B2 (en) 2005-03-15 2012-07-17 Cook Medical Technologies Embolic protection device
US20060259132A1 (en) * 2005-05-02 2006-11-16 Cook Incorporated Vascular stent for embolic protection
US8109962B2 (en) 2005-06-20 2012-02-07 Cook Medical Technologies Llc Retrievable device having a reticulation portion with staggered struts
US7850708B2 (en) * 2005-06-20 2010-12-14 Cook Incorporated Embolic protection device having a reticulated body with staggered struts
US20070001346A1 (en) * 2005-06-30 2007-01-04 Murty Vyakarnam Active embolization device
US7780695B2 (en) * 2005-06-30 2010-08-24 Codman & Shurtleff, Inc. Chemically based vascular occlusion device deployment
US7766934B2 (en) * 2005-07-12 2010-08-03 Cook Incorporated Embolic protection device with an integral basket and bag
US7771452B2 (en) 2005-07-12 2010-08-10 Cook Incorporated Embolic protection device with a filter bag that disengages from a basket
US8187298B2 (en) * 2005-08-04 2012-05-29 Cook Medical Technologies Llc Embolic protection device having inflatable frame
US8377092B2 (en) 2005-09-16 2013-02-19 Cook Medical Technologies Llc Embolic protection device
US8632562B2 (en) * 2005-10-03 2014-01-21 Cook Medical Technologies Llc Embolic protection device
US8182508B2 (en) * 2005-10-04 2012-05-22 Cook Medical Technologies Llc Embolic protection device
US8252017B2 (en) * 2005-10-18 2012-08-28 Cook Medical Technologies Llc Invertible filter for embolic protection
KR101334502B1 (en) 2005-10-19 2013-12-05 펄사 배스큘러, 아이엔씨. Method and systems for endovascularly clipping and repairing lumen and tissue defects
CN103381101B (en) * 2005-10-19 2017-12-01 帕尔萨脉管公司 For the method and system of clamping and repairing lumen and tissue defects in vascular
US8216269B2 (en) 2005-11-02 2012-07-10 Cook Medical Technologies Llc Embolic protection device having reduced profile
US20070100372A1 (en) * 2005-11-02 2007-05-03 Cook Incorporated Embolic protection device having a filter
US8152831B2 (en) * 2005-11-17 2012-04-10 Cook Medical Technologies Llc Foam embolic protection device
US20070225680A1 (en) * 2006-03-21 2007-09-27 Medtronic Vascular, Inc. Guiding catheter with chemically softened distal portion and method of making same
EP2015683B1 (en) * 2006-04-17 2015-12-09 Covidien LP System for mechanically positioning intravascular implants
US8777979B2 (en) 2006-04-17 2014-07-15 Covidien Lp System and method for mechanically positioning intravascular implants
KR101443926B1 (en) 2006-06-15 2014-10-02 마이크로벤션, 인코포레이티드 Embolization device constructed from expansible polymer
US20080071307A1 (en) * 2006-09-19 2008-03-20 Cook Incorporated Apparatus and methods for in situ embolic protection
WO2008042266A2 (en) * 2006-09-28 2008-04-10 Cook Incorporated Thoracic aortic aneurysm repair apparatus and method
CN101541355B (en) 2006-10-17 2012-08-08 雷瓦医药公司 N-substituted monomers and polymers
KR101297043B1 (en) 2006-10-22 2013-08-14 이데브 테크놀로지스, 아이엔씨. Methods for securing strand ends and the resulting devices
EP2083767B1 (en) 2006-10-22 2019-04-03 IDEV Technologies, INC. Devices for stent advancement
US20080114402A1 (en) * 2006-11-10 2008-05-15 Warsaw Orthopedic, Inc. Devices and Methods for Correcting a Spinal Deformity
WO2008074027A1 (en) * 2006-12-13 2008-06-19 Biomerix Corporation Aneurysm occlusion devices
US9901434B2 (en) 2007-02-27 2018-02-27 Cook Medical Technologies Llc Embolic protection device including a Z-stent waist band
US8257719B2 (en) * 2007-03-06 2012-09-04 Ranir, Llc Oral care layer and related method of manufacture
JP5227344B2 (en) 2007-03-13 2013-07-03 タイコ ヘルスケア グループ リミテッド パートナーシップ Implant, mandrel, and implant formation method
JP5249249B2 (en) * 2007-03-13 2013-07-31 コヴィディエン リミテッド パートナーシップ Implant including a coil and a stretch resistant member
JP5120058B2 (en) 2007-05-23 2013-01-16 日本精工株式会社 State quantity measuring device for rolling bearing unit and manufacturing method thereof
EP2162101B1 (en) * 2007-06-25 2019-02-20 MicroVention, Inc. Self-expanding prosthesis
US9138307B2 (en) 2007-09-14 2015-09-22 Cook Medical Technologies Llc Expandable device for treatment of a stricture in a body vessel
US8419748B2 (en) * 2007-09-14 2013-04-16 Cook Medical Technologies Llc Helical thrombus removal device
US8252018B2 (en) * 2007-09-14 2012-08-28 Cook Medical Technologies Llc Helical embolic protection device
US8088140B2 (en) 2008-05-19 2012-01-03 Mindframe, Inc. Blood flow restorative and embolus removal methods
US9220522B2 (en) * 2007-10-17 2015-12-29 Covidien Lp Embolus removal systems with baskets
US8926680B2 (en) * 2007-11-12 2015-01-06 Covidien Lp Aneurysm neck bridging processes with revascularization systems methods and products thereby
US8585713B2 (en) 2007-10-17 2013-11-19 Covidien Lp Expandable tip assembly for thrombus management
US20100174309A1 (en) * 2008-05-19 2010-07-08 Mindframe, Inc. Recanalization/revascularization and embolus addressing systems including expandable tip neuro-microcatheter
US20100256600A1 (en) * 2009-04-04 2010-10-07 Ferrera David A Neurovascular otw pta balloon catheter and delivery system
US8066757B2 (en) * 2007-10-17 2011-11-29 Mindframe, Inc. Blood flow restoration and thrombus management methods
US10123803B2 (en) 2007-10-17 2018-11-13 Covidien Lp Methods of managing neurovascular obstructions
US9198687B2 (en) * 2007-10-17 2015-12-01 Covidien Lp Acute stroke revascularization/recanalization systems processes and products thereby
US11337714B2 (en) 2007-10-17 2022-05-24 Covidien Lp Restoring blood flow and clot removal during acute ischemic stroke
US20090137981A1 (en) * 2007-11-26 2009-05-28 Valor Medical Methods of treating a blood vessel
WO2009086208A2 (en) 2007-12-21 2009-07-09 Microvention, Inc. Hydrogel filaments for biomedical uses
CN102036619B (en) 2007-12-21 2014-07-23 微排放器公司 A system and method of detecting implant detachment
CN102065779B (en) 2007-12-21 2014-02-12 微排放器公司 System and method for locating detachment zone of detachable implant
US8940003B2 (en) 2008-02-22 2015-01-27 Covidien Lp Methods and apparatus for flow restoration
US20090227976A1 (en) * 2008-03-05 2009-09-10 Calabria Marie F Multiple biocompatible polymeric strand aneurysm embolization system and method
EP2271390A4 (en) * 2008-04-11 2016-07-20 Covidien Lp Monorail neuro-microcatheter for delivery of medical devices to treat stroke, processes and products thereby
US20090318948A1 (en) * 2008-04-22 2009-12-24 Coherex Medical, Inc. Device, system and method for aneurysm embolization
US10716573B2 (en) 2008-05-01 2020-07-21 Aneuclose Janjua aneurysm net with a resilient neck-bridging portion for occluding a cerebral aneurysm
US10028747B2 (en) 2008-05-01 2018-07-24 Aneuclose Llc Coils with a series of proximally-and-distally-connected loops for occluding a cerebral aneurysm
EP2444116B1 (en) 2008-08-19 2016-01-06 Covidien LP Detachable tip microcatheter
US8133199B2 (en) 2008-08-27 2012-03-13 Boston Scientific Scimed, Inc. Electroactive polymer activation system for a medical device
KR20110102422A (en) * 2008-12-10 2011-09-16 마이크로벤션, 인코포레이티드 Microcatheter
US8388644B2 (en) 2008-12-29 2013-03-05 Cook Medical Technologies Llc Embolic protection device and method of use
US20100211094A1 (en) * 2009-02-18 2010-08-19 Cook Incorporated Umbrella distal embolic protection device
WO2010117883A1 (en) * 2009-04-06 2010-10-14 Boston Scientific Scimed, Inc. Delivery wire for occlusive device delivery system
US20100274277A1 (en) * 2009-04-27 2010-10-28 Cook Incorporated Embolic protection device with maximized flow-through
US10639396B2 (en) 2015-06-11 2020-05-05 Microvention, Inc. Polymers
JP5472595B2 (en) * 2009-08-26 2014-04-16 セイコーエプソン株式会社 Liquid ejecting head and liquid ejecting apparatus
EP2480166B1 (en) * 2009-09-24 2017-11-29 Microvention, Inc. Injectable hydrogel filaments for biomedical uses
US8434489B2 (en) * 2009-10-23 2013-05-07 Conceptus, Inc. Contraceptive devices and methods
BR112012009287A2 (en) * 2009-10-26 2017-06-06 Microvention Inc embolization device made of expandable polymer
US9358140B1 (en) 2009-11-18 2016-06-07 Aneuclose Llc Stent with outer member to embolize an aneurysm
AU2011240927B2 (en) 2010-04-14 2015-07-16 Microvention, Inc. Implant delivery device
US9023095B2 (en) 2010-05-27 2015-05-05 Idev Technologies, Inc. Stent delivery system with pusher assembly
US9192746B2 (en) * 2010-06-07 2015-11-24 Cook Medical Technologies Llc Reperfusion catheter system
JP6066931B2 (en) 2011-02-25 2017-01-25 マイクロベンション インコーポレイテッド Reinforced balloon catheter
US10028745B2 (en) 2011-03-30 2018-07-24 Noha, Llc Advanced endovascular clip and method of using same
US10398444B2 (en) 2011-03-30 2019-09-03 Noha, Llc Advanced endovascular clip and method of using same
WO2012145431A2 (en) 2011-04-18 2012-10-26 Microvention, Inc. Embolic devices
KR102018035B1 (en) 2011-06-03 2019-09-05 펄사 배스큘라, 아이엔씨. Aneurysm devices with additional anchoring mechanisms and associated systems and methods
WO2013049837A1 (en) 2011-09-30 2013-04-04 Medicalcue, Inc. Umbilical probe measurement systems
US9119625B2 (en) 2011-10-05 2015-09-01 Pulsar Vascular, Inc. Devices, systems and methods for enclosing an anatomical opening
US9579104B2 (en) 2011-11-30 2017-02-28 Covidien Lp Positioning and detaching implants
KR101315443B1 (en) 2011-12-02 2013-10-07 강호창 Micro-coil assembly
US9011480B2 (en) 2012-01-20 2015-04-21 Covidien Lp Aneurysm treatment coils
US9687245B2 (en) 2012-03-23 2017-06-27 Covidien Lp Occlusive devices and methods of use
WO2013158781A1 (en) 2012-04-18 2013-10-24 Microvention, Inc. Embolic devices
SG11201406845YA (en) 2012-04-24 2014-11-27 Urogyn B V Bulking agent applicator for treating female urinary incontinence
EP2656822B1 (en) * 2012-04-24 2014-12-03 Urogyn B.V. Applicator for delivering an occluding compound in a fallopian tube
WO2013166475A1 (en) 2012-05-04 2013-11-07 Interventco Llc Device and method for filling of aneurysm or body cavity
US10124087B2 (en) 2012-06-19 2018-11-13 Covidien Lp Detachable coupling for catheter
CA2904862A1 (en) 2013-03-14 2014-10-02 Incumedx Inc. Implants, methods of manufacturing the same, and devices and methods for delivering the implants to a vascular disorder of a patient
EP3068337B1 (en) 2013-11-13 2022-10-05 Covidien LP Galvanically assisted attachment of medical devices to thrombus
US10398441B2 (en) 2013-12-20 2019-09-03 Terumo Corporation Vascular occlusion
US11224437B2 (en) 2014-01-14 2022-01-18 Penumbra, Inc. Soft embolic implant
US10124090B2 (en) 2014-04-03 2018-11-13 Terumo Corporation Embolic devices
US9713475B2 (en) 2014-04-18 2017-07-25 Covidien Lp Embolic medical devices
CN106456836B (en) 2014-04-29 2019-12-06 微仙美国有限公司 Polymers comprising active agents
US10092663B2 (en) 2014-04-29 2018-10-09 Terumo Corporation Polymers
US20150327868A1 (en) * 2014-05-13 2015-11-19 Ndi Tip Teknolojileri Anonim Sirketi Retractable and rapid disconnect, floating diameter embolic coil product and delivery system
WO2016039979A2 (en) 2014-09-08 2016-03-17 Stryker Corporation Vaso-occlusive devices with in-situ stiffening
CN107249483B (en) * 2014-09-15 2020-04-28 恩波医疗有限公司 Embolization device
US10857012B2 (en) 2015-01-20 2020-12-08 Neurogami Medical, Inc. Vascular implant
US10736730B2 (en) 2015-01-20 2020-08-11 Neurogami Medical, Inc. Vascular implant
US11484319B2 (en) 2015-01-20 2022-11-01 Neurogami Medical, Inc. Delivery system for micrograft for treating intracranial aneurysms
CA2972620C (en) 2015-01-20 2023-08-01 Neurogami Medical, Inc. Micrograft for the treatment of intracranial aneurysms and method for use
US10925611B2 (en) 2015-01-20 2021-02-23 Neurogami Medical, Inc. Packaging for surgical implant
US10265515B2 (en) 2015-03-27 2019-04-23 Covidien Lp Galvanically assisted aneurysm treatment
US10307168B2 (en) 2015-08-07 2019-06-04 Terumo Corporation Complex coil and manufacturing techniques
WO2017053784A1 (en) 2015-09-25 2017-03-30 Covidien Lp Medical device delivery system
US10052108B2 (en) 2015-10-30 2018-08-21 Incumedx, Inc. Devices and methods for delivering an implant to a vascular disorder
US11090055B2 (en) 2015-10-30 2021-08-17 Incumedx Inc. Devices and methods for delivering an implant to a vascular disorder
US10420563B2 (en) 2016-07-08 2019-09-24 Neurogami Medical, Inc. Delivery system insertable through body lumen
JP6869533B2 (en) * 2017-03-09 2021-05-12 国立大学法人大阪大学 Multi-node annular elastic body
US11129621B2 (en) * 2018-12-17 2021-09-28 Covidien Lp Devices, systems, and methods for the treatment of vascular defects
KR102316501B1 (en) * 2019-07-17 2021-10-22 한스바이오메드 주식회사 Anchor for embolic coil and embolic coil including the same
CN113546234B (en) * 2020-04-24 2022-09-20 苏州医本生命科技有限公司 Medicinal preparation with tracing function for vascular intervention and its delivery system
KR20220046162A (en) 2020-10-07 2022-04-14 주식회사 엘지생활건강 Composition for improving skin conditions comprising the extract of Allium ulleungense
CN116761559A (en) * 2020-11-19 2023-09-15 波士顿科学国际有限公司 Apparatus, system and method for coating coils

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU184722B (en) * 1980-02-18 1984-10-29 Laszlo Lazar Therapeutically suitable silicone rubber mixture and therapeuticaid
US4795741A (en) * 1987-05-06 1989-01-03 Biomatrix, Inc. Compositions for therapeutic percutaneous embolization and the use thereof
US4819637A (en) * 1987-09-01 1989-04-11 Interventional Therapeutics Corporation System for artificial vessel embolization and devices for use therewith
US4994069A (en) * 1988-11-02 1991-02-19 Target Therapeutics Vaso-occlusion coil and method
US5163952A (en) * 1990-09-14 1992-11-17 Michael Froix Expandable polymeric stent with memory and delivery apparatus and method
US5167624A (en) * 1990-11-09 1992-12-01 Catheter Research, Inc. Embolus delivery system and method
US5133731A (en) * 1990-11-09 1992-07-28 Catheter Research, Inc. Embolus supply system and method
US5226911A (en) * 1991-10-02 1993-07-13 Target Therapeutics Vasoocclusion coil with attached fibrous element(s)
JP3356447B2 (en) * 1991-10-16 2002-12-16 テルモ株式会社 Vascular lesion embolic material composed of dried polymer gel
US5443478A (en) * 1992-09-02 1995-08-22 Board Of Regents, The University Of Texas System Multi-element intravascular occlusion device
US5469867A (en) * 1992-09-02 1995-11-28 Landec Corporation Cast-in place thermoplastic channel occluder
US5312415A (en) * 1992-09-22 1994-05-17 Target Therapeutics, Inc. Assembly for placement of embolic coils using frictional placement
EP0617633B1 (en) * 1992-09-22 1999-12-01 Target Therapeutics Detachable embolic coil assembly
US5350397A (en) * 1992-11-13 1994-09-27 Target Therapeutics, Inc. Axially detachable embolic coil assembly
US5382259A (en) * 1992-10-26 1995-01-17 Target Therapeutics, Inc. Vasoocclusion coil with attached tubular woven or braided fibrous covering
US5382260A (en) * 1992-10-30 1995-01-17 Interventional Therapeutics Corp. Embolization device and apparatus including an introducer cartridge and method for delivering the same
US5690666A (en) * 1992-11-18 1997-11-25 Target Therapeutics, Inc. Ultrasoft embolism coils and process for using them
US5443454A (en) * 1992-12-09 1995-08-22 Terumo Kabushiki Kaisha Catheter for embolectomy
ES2123135T3 (en) * 1993-03-23 1999-01-01 Focal Inc APPARATUS AND METHOD FOR LOCAL APPLICATION OF POLYMERIC MATERIAL TO FABRIC.
JP2535785B2 (en) * 1994-06-03 1996-09-18 工業技術院長 Vascular embolic agent
ES2340142T3 (en) * 1994-07-08 2010-05-31 Ev3 Inc. SYSTEM TO CARRY OUT AN INTRAVASCULAR PROCEDURE.
US5690671A (en) 1994-12-13 1997-11-25 Micro Interventional Systems, Inc. Embolic elements and methods and apparatus for their delivery
US5814062A (en) * 1994-12-22 1998-09-29 Target Therapeutics, Inc. Implant delivery assembly with expandable coupling/decoupling mechanism
US5578074A (en) * 1994-12-22 1996-11-26 Target Therapeutics, Inc. Implant delivery method and assembly
US5634936A (en) * 1995-02-06 1997-06-03 Scimed Life Systems, Inc. Device for closing a septal defect
US5645558A (en) * 1995-04-20 1997-07-08 Medical University Of South Carolina Anatomically shaped vasoocclusive device and method of making the same
US5624461A (en) * 1995-06-06 1997-04-29 Target Therapeutics, Inc. Three dimensional in-filling vaso-occlusive coils
WO1997001368A1 (en) * 1995-06-26 1997-01-16 Trimedyne, Inc. Therapeutic appliance releasing device
US5725568A (en) * 1995-06-27 1998-03-10 Scimed Life Systems, Inc. Method and device for recanalizing and grafting arteries
US5582619A (en) * 1995-06-30 1996-12-10 Target Therapeutics, Inc. Stretch resistant vaso-occlusive coils
US5580568A (en) * 1995-07-27 1996-12-03 Micro Therapeutics, Inc. Cellulose diacetate compositions for use in embolizing blood vessels
US5667767A (en) * 1995-07-27 1997-09-16 Micro Therapeutics, Inc. Compositions for use in embolizing blood vessels
US6090063A (en) * 1995-12-01 2000-07-18 C. R. Bard, Inc. Device, system and method for implantation of filaments and particles in the body
US5658308A (en) * 1995-12-04 1997-08-19 Target Therapeutics, Inc. Bioactive occlusion coil
US5749894A (en) * 1996-01-18 1998-05-12 Target Therapeutics, Inc. Aneurysm closure method
US5702361A (en) * 1996-01-31 1997-12-30 Micro Therapeutics, Inc. Method for embolizing blood vessels
US5830178A (en) * 1996-10-11 1998-11-03 Micro Therapeutics, Inc. Methods for embolizing vascular sites with an emboilizing composition comprising dimethylsulfoxide
US5895391A (en) * 1996-09-27 1999-04-20 Target Therapeutics, Inc. Ball lock joint and introducer for vaso-occlusive member
US6159165A (en) 1997-12-05 2000-12-12 Micrus Corporation Three dimensional spherical micro-coils manufactured from radiopaque nickel-titanium microstrand
US5941888A (en) * 1998-02-18 1999-08-24 Target Therapeutics, Inc. Vaso-occlusive member assembly with multiple detaching points
ATE516759T1 (en) * 2001-05-29 2011-08-15 Microvention Inc METHOD FOR PRODUCING EXPANDABLE FILAMENTOUS EMBOLIZATION DEVICES

Also Published As

Publication number Publication date
EP1806106A2 (en) 2007-07-11
AU3860999A (en) 1999-11-16
ATE359031T1 (en) 2007-05-15
CA2736639A1 (en) 1999-11-04
AU764797C (en) 2004-07-22
AU2003264582A1 (en) 2004-01-08
EP1806106A3 (en) 2007-10-31
BR9910027A (en) 2000-12-26
EP1518502A1 (en) 2005-03-30
CN1298287A (en) 2001-06-06
ES2232136T3 (en) 2005-05-16
EP1518502B1 (en) 2007-04-11
AU764797B2 (en) 2003-08-28
JP2002512837A (en) 2002-05-08
DE69935814D1 (en) 2007-05-24
ES2384988T3 (en) 2012-07-16
DE69935814T2 (en) 2007-12-27
ES2285319T3 (en) 2007-11-16
JP2007136236A (en) 2007-06-07
CA2647850A1 (en) 1999-11-04
CN1200648C (en) 2005-05-11
JP4376458B2 (en) 2009-12-02
CA2647850C (en) 2011-06-21
AU2009201669A1 (en) 2009-05-21
JP4794477B2 (en) 2011-10-19
AU2003264582B2 (en) 2006-09-07
DE69921979T2 (en) 2005-11-24
WO1999055239A1 (en) 1999-11-04
US6375669B1 (en) 2002-04-23
DE69921979D1 (en) 2004-12-23
EP1073377B1 (en) 2004-11-17
EP1806106B1 (en) 2012-04-04
CA2330136C (en) 2009-02-17
AU2006249217B2 (en) 2009-01-29
AU2006249217A1 (en) 2007-01-04
ATE282362T1 (en) 2004-12-15
US6015424A (en) 2000-01-18
EP1073377A1 (en) 2001-02-07

Similar Documents

Publication Publication Date Title
CA2330136A1 (en) Apparatus and method for vascular embolization
US20210137527A1 (en) Expandable implant and implant system
US6984240B1 (en) Detachable multidiameter vasoocclusive coil
EP2008596B1 (en) Embolic device
EP2260795A3 (en) Devices for repairing aneurysms
US6004338A (en) Stretch resistant vaso-occlusive coils
EP0807410A3 (en) Electrolytically severable joint for endovascular embolic devices
EP1339328B1 (en) Mechanism for the deployment of endovascular implants
CA2481224A1 (en) Devices for retaining vaso-occlussive devices within an aneurysm
CA2494287C (en) Three element coaxial vaso-occlusive device
US20020120276A1 (en) Filamentous embolic device with expansile elements
DE60205007D1 (en) Reloadable catheter system sheath for introducing vascular occlusion devices
US20040034386A1 (en) Aneurysm stent
WO2002053042A3 (en) Apparatus and method for embolizing an aneurysm with magnetically-controllable substance
EP1316293A3 (en) Aneurysm embolic device with an occlusive member
CA2334223A1 (en) Endovascular thin film devices and methods for treating and preventing stroke
NO973973D0 (en) Electrolytically positionable braided vaso-occlusion device
US20080066763A1 (en) Fallopian Tube Occlusion Devices and Methods
RU99106797A (en) KIT FOR TRANSLUMINAL INTRODUCTION OF TUBULAR STENT AND ENDOVASCULAR TRANSPLANT
EP1225836A1 (en) Filamentous embolic device with expansible elements
CA2917135A1 (en) Occlusion device with openable channel
Wilson et al. Expandable implant and implant system

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20180423