CA2316361A1 - A method for predicting an abnormal level of clotting proteins - Google Patents
A method for predicting an abnormal level of clotting proteins Download PDFInfo
- Publication number
- CA2316361A1 CA2316361A1 CA002316361A CA2316361A CA2316361A1 CA 2316361 A1 CA2316361 A1 CA 2316361A1 CA 002316361 A CA002316361 A CA 002316361A CA 2316361 A CA2316361 A CA 2316361A CA 2316361 A1 CA2316361 A1 CA 2316361A1
- Authority
- CA
- Canada
- Prior art keywords
- time
- abnormal level
- predicting
- dependent measurement
- proteins
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/4905—Determining clotting time of blood
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/22—Haematology
- G01N2800/226—Thrombotic disorders, i.e. thrombo-embolism irrespective of location/organ involved, e.g. renal vein thrombosis, venous thrombosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/38—Pediatrics
- G01N2800/385—Congenital anomalies
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
Abstract
A method is disclosed for predicting the presence of an abnormal level of one or more proteins in the clotting cascade from at least one time-dependent measurement profile. At least one time-dependent measurement on an unknown sample (103) is performed and a respective property of the sample is measured over time so as to derive a time-dependent measurement profile (101).
A set of a plurality of predictor variables (110) are defined which sufficiently define the data of the time-dependent measurement profile (101). A model (113) is then derived that represents the relationship between the abnormality and the set of predictor variables (110). Subsequently, the model (113) is utilized to predict which protein or proteins in the clotting cascade are at an abnormal level, with the prediction (120) being a better prediction than clot time alone.
A set of a plurality of predictor variables (110) are defined which sufficiently define the data of the time-dependent measurement profile (101). A model (113) is then derived that represents the relationship between the abnormality and the set of predictor variables (110). Subsequently, the model (113) is utilized to predict which protein or proteins in the clotting cascade are at an abnormal level, with the prediction (120) being a better prediction than clot time alone.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/001,647 US6321164B1 (en) | 1995-06-07 | 1997-12-31 | Method and apparatus for predicting the presence of an abnormal level of one or more proteins in the clotting cascade |
US09/001,647 | 1997-12-31 | ||
PCT/US1998/027865 WO1999034208A1 (en) | 1997-12-31 | 1998-12-30 | A method for predicting an abnormal level of clotting proteins |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2316361A1 true CA2316361A1 (en) | 1999-07-08 |
CA2316361C CA2316361C (en) | 2007-11-27 |
Family
ID=21697133
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002316361A Expired - Fee Related CA2316361C (en) | 1997-12-31 | 1998-12-30 | A method for predicting an abnormal level of clotting proteins |
Country Status (7)
Country | Link |
---|---|
US (2) | US6321164B1 (en) |
EP (1) | EP1042669A4 (en) |
JP (1) | JP2002500360A (en) |
KR (1) | KR20010033817A (en) |
AU (1) | AU1950399A (en) |
CA (1) | CA2316361C (en) |
WO (1) | WO1999034208A1 (en) |
Families Citing this family (31)
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US6898532B1 (en) | 1995-06-07 | 2005-05-24 | Biomerieux, Inc. | Method and apparatus for predicting the presence of haemostatic dysfunction in a patient sample |
US6502040B2 (en) | 1997-12-31 | 2002-12-31 | Biomerieux, Inc. | Method for presenting thrombosis and hemostasis assay data |
EP1522860A1 (en) * | 1999-02-04 | 2005-04-13 | bioMérieux, Inc. | A method and apparatus for predicting the presence of haemostatic dysfunction in a patient sample |
EP1147423B1 (en) * | 1999-02-04 | 2004-11-10 | bioMérieux, Inc. | A method and apparatus for predicting the presence of haemostatic dysfunction in a patient sample |
US7179612B2 (en) | 2000-06-09 | 2007-02-20 | Biomerieux, Inc. | Method for detecting a lipoprotein-acute phase protein complex and predicting an increased risk of system failure or mortality |
US6743596B1 (en) * | 2000-10-27 | 2004-06-01 | Biomerieux, Inc. | Method of determining global coagulability hemostatic potential |
US6952209B2 (en) * | 2001-06-27 | 2005-10-04 | Agilent Technologies, Inc. | Variable scaled graphical indicator to display dynamic data |
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DE102004059055A1 (en) * | 2004-12-07 | 2006-06-08 | Dade Behring Marburg Gmbh | Method for automatically determining endogenous thrombin potential |
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WO2014021994A1 (en) * | 2012-08-03 | 2014-02-06 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Method and apparatus for aiding in the diagnosis of otitis media by classifying tympanic membrane images |
US11169161B2 (en) | 2014-12-18 | 2021-11-09 | Koninklijke Philips N.V. | Device, system and method for determining a fibrinogen level in a blood sample |
US10460237B2 (en) | 2015-11-30 | 2019-10-29 | International Business Machines Corporation | Neuron-centric local learning rate for artificial neural networks to increase performance, learning rate margin, and reduce power consumption |
AU2017250570A1 (en) | 2016-04-15 | 2018-11-15 | Takeda Pharmaceutical Company Limited | Method and apparatus for providing a pharmacokinetic drug dosing regiment |
EP3519828A4 (en) | 2016-09-29 | 2020-06-03 | Animantis, LLC | Methods and apparatus for assessing immune system activity and therapeutic efficacy |
EP3571504A4 (en) | 2017-01-23 | 2020-10-28 | The Administrators of the Tulane Educational Fund | Apparatus, systems and methods for integrative photo- optical/mechanical test for noncontact measurement of polymerization |
US10896749B2 (en) | 2017-01-27 | 2021-01-19 | Shire Human Genetic Therapies, Inc. | Drug monitoring tool |
JP6952668B2 (en) * | 2018-09-28 | 2021-10-20 | シスメックス株式会社 | Blood coagulation analysis method, blood coagulation analyzer, program |
CN111539479B (en) * | 2020-04-27 | 2023-08-08 | 北京百度网讯科技有限公司 | Method and device for generating sample data |
JP2022062969A (en) | 2020-10-09 | 2022-04-21 | シスメックス株式会社 | Blood sample analysis method, analysis device, and analysis program |
CN112735535B (en) * | 2021-04-01 | 2021-06-25 | 腾讯科技(深圳)有限公司 | Prediction model training method, prediction model training device, data prediction method, data prediction device and storage medium |
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-
1997
- 1997-12-31 US US09/001,647 patent/US6321164B1/en not_active Expired - Fee Related
-
1998
- 1998-12-30 EP EP98964342A patent/EP1042669A4/en not_active Withdrawn
- 1998-12-30 CA CA002316361A patent/CA2316361C/en not_active Expired - Fee Related
- 1998-12-30 KR KR1020007007373A patent/KR20010033817A/en not_active Application Discontinuation
- 1998-12-30 JP JP2000526808A patent/JP2002500360A/en not_active Withdrawn
- 1998-12-30 AU AU19503/99A patent/AU1950399A/en not_active Abandoned
- 1998-12-30 WO PCT/US1998/027865 patent/WO1999034208A1/en not_active Application Discontinuation
-
2001
- 2001-05-07 US US09/850,255 patent/US6564153B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6321164B1 (en) | 2001-11-20 |
KR20010033817A (en) | 2001-04-25 |
CA2316361C (en) | 2007-11-27 |
WO1999034208A1 (en) | 1999-07-08 |
US6564153B2 (en) | 2003-05-13 |
JP2002500360A (en) | 2002-01-08 |
US20020019706A1 (en) | 2002-02-14 |
EP1042669A4 (en) | 2004-12-08 |
EP1042669A1 (en) | 2000-10-11 |
AU1950399A (en) | 1999-07-19 |
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