CA2307623A1 - Serpentine electrophoresis channel with self-correcting bends - Google Patents
Serpentine electrophoresis channel with self-correcting bends Download PDFInfo
- Publication number
- CA2307623A1 CA2307623A1 CA002307623A CA2307623A CA2307623A1 CA 2307623 A1 CA2307623 A1 CA 2307623A1 CA 002307623 A CA002307623 A CA 002307623A CA 2307623 A CA2307623 A CA 2307623A CA 2307623 A1 CA2307623 A1 CA 2307623A1
- Authority
- CA
- Canada
- Prior art keywords
- alpha
- channel
- angle
- self
- curved
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44756—Apparatus specially adapted therefor
- G01N27/44791—Microapparatus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N2030/285—Control of physical parameters of the fluid carrier electrically driven carrier
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
- G01N30/6095—Micromachined or nanomachined, e.g. micro- or nanosize
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S366/00—Agitating
- Y10S366/03—Micromixers: variable geometry from the pathway influences mixing/agitation of non-laminar fluid flow
Abstract
A serpentine electrophoresis channel, e.g., for a microchip format, is disclosed. The channel includes pairs of linear segments, e.g., parallel or right-angle segments, each joined by an angled channel region having a first curved channel portion subtending an angle .alpha. f>.alpha.
where .alpha. is the angle between segments in a pair, and a second curved channel portion subtending an angle .alpha. s = .alpha. f-.alpha.. The angles and cross sections of the two channel portions are such that .delta.t f, the time differential of analyte migration at inner and outer tracks in the first curved portion is equal to .delta.t s, the time differential of analyte migration at outer and inner tracks in the second curved portion, respectively.
where .alpha. is the angle between segments in a pair, and a second curved channel portion subtending an angle .alpha. s = .alpha. f-.alpha.. The angles and cross sections of the two channel portions are such that .delta.t f, the time differential of analyte migration at inner and outer tracks in the first curved portion is equal to .delta.t s, the time differential of analyte migration at outer and inner tracks in the second curved portion, respectively.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6510097P | 1997-11-12 | 1997-11-12 | |
US60/065,100 | 1997-11-12 | ||
PCT/US1998/024202 WO1999024828A1 (en) | 1997-11-12 | 1998-11-12 | Serpentine electrophoresis channel with self-correcting bends |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2307623A1 true CA2307623A1 (en) | 1999-05-20 |
CA2307623C CA2307623C (en) | 2004-03-16 |
Family
ID=22060347
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002307623A Expired - Fee Related CA2307623C (en) | 1997-11-12 | 1998-11-12 | Serpentine electrophoresis channel with self-correcting bends |
Country Status (8)
Country | Link |
---|---|
US (1) | US6176991B1 (en) |
EP (1) | EP1031032B1 (en) |
JP (1) | JP2001523001A (en) |
AT (1) | ATE220456T1 (en) |
AU (1) | AU747940B2 (en) |
CA (1) | CA2307623C (en) |
DE (1) | DE69806499T2 (en) |
WO (1) | WO1999024828A1 (en) |
Families Citing this family (57)
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US6830729B1 (en) | 1998-05-18 | 2004-12-14 | University Of Washington | Sample analysis instrument |
EP1046032A4 (en) * | 1998-05-18 | 2002-05-29 | Univ Washington | Liquid analysis cartridge |
US6913679B1 (en) | 1999-02-11 | 2005-07-05 | The Regents Of The University Of California | Apparatus and methods for high resolution separation of sample components on microfabricated channel devices |
US6270641B1 (en) | 1999-04-26 | 2001-08-07 | Sandia Corporation | Method and apparatus for reducing sample dispersion in turns and junctions of microchannel systems |
US7538237B2 (en) * | 1999-07-02 | 2009-05-26 | Kreido Laboratories | Process for high shear gas-liquid reactions |
US6742774B2 (en) * | 1999-07-02 | 2004-06-01 | Holl Technologies Company | Process for high shear gas-liquid reactions |
US6471392B1 (en) * | 2001-03-07 | 2002-10-29 | Holl Technologies Company | Methods and apparatus for materials processing |
JP2001281233A (en) * | 2000-03-28 | 2001-10-10 | Inst Of Physical & Chemical Res | Microchip for water distribution and water distribution method using it |
US6902313B2 (en) * | 2000-08-10 | 2005-06-07 | University Of California | Micro chaotic mixer |
US20020060153A1 (en) * | 2000-11-06 | 2002-05-23 | Dna Sciences, Inc. | Microchannel turn design |
US6830806B2 (en) * | 2001-04-12 | 2004-12-14 | Kreido Laboratories | Methods of manufacture of electric circuit substrates and components having multiple electric characteristics and substrates and components so manufactured |
US6596140B2 (en) | 2001-05-01 | 2003-07-22 | Applera Corporation | Multi-channel capillary electrophoresis device and method |
KR100442680B1 (en) * | 2001-05-10 | 2004-08-02 | 주식회사 디지탈바이오테크놀러지 | Apparatus for mixing fluids by micro channel |
KR100442681B1 (en) * | 2001-05-10 | 2004-08-02 | 주식회사 디지탈바이오테크놀러지 | Channel unit and apparatus for mixing fluids using the unit |
US6919058B2 (en) * | 2001-08-28 | 2005-07-19 | Gyros Ab | Retaining microfluidic microcavity and other microfluidic structures |
AU2002336510A1 (en) * | 2001-09-13 | 2003-03-24 | Holl Technologies Company | Methods and apparatus for transfer of heat energy between a body surface and heat transfer fluid |
US6787246B2 (en) | 2001-10-05 | 2004-09-07 | Kreido Laboratories | Manufacture of flat surfaced composites comprising powdered fillers in a polymer matrix |
KR100473364B1 (en) * | 2001-10-17 | 2005-03-08 | 주식회사 디지탈바이오테크놀러지 | Microchannel apparatus for mixing liquids using microchannel and method therefor |
US7459127B2 (en) * | 2002-02-26 | 2008-12-02 | Siemens Healthcare Diagnostics Inc. | Method and apparatus for precise transfer and manipulation of fluids by centrifugal and/or capillary forces |
US7005301B2 (en) * | 2002-06-10 | 2006-02-28 | Sandia National Laboratories | Piecewise uniform conduction-like flow channels and method therefor |
US20050238506A1 (en) * | 2002-06-21 | 2005-10-27 | The Charles Stark Draper Laboratory, Inc. | Electromagnetically-actuated microfluidic flow regulators and related applications |
US7098360B2 (en) * | 2002-07-16 | 2006-08-29 | Kreido Laboratories | Processes employing multiple successive chemical reaction process steps and apparatus therefore |
BR0314521A (en) * | 2002-09-11 | 2005-07-26 | Kreido Lab | Methods and devices for high shear material mixers and reactors |
AU2003288916A1 (en) * | 2002-10-03 | 2004-04-23 | Kredo Laboratories | Apparatus for transfer of heat energy between a body surface and heat transfer fluid |
US7094354B2 (en) * | 2002-12-19 | 2006-08-22 | Bayer Healthcare Llc | Method and apparatus for separation of particles in a microfluidic device |
DE10303107B3 (en) * | 2003-01-27 | 2004-09-16 | Sls Micro Technology Gmbh | Separation column, in particular for a miniaturized gas chromatograph |
WO2004113898A1 (en) * | 2003-05-19 | 2004-12-29 | Protasis Corporation | Electrophoresis devices and methods for focusing charged analytes |
US7435381B2 (en) * | 2003-05-29 | 2008-10-14 | Siemens Healthcare Diagnostics Inc. | Packaging of microfluidic devices |
US7160025B2 (en) * | 2003-06-11 | 2007-01-09 | Agency For Science, Technology And Research | Micromixer apparatus and methods of using same |
US20080257754A1 (en) * | 2003-06-27 | 2008-10-23 | Pugia Michael J | Method and apparatus for entry of specimens into a microfluidic device |
US20040265172A1 (en) * | 2003-06-27 | 2004-12-30 | Pugia Michael J. | Method and apparatus for entry and storage of specimens into a microfluidic device |
US20040265171A1 (en) * | 2003-06-27 | 2004-12-30 | Pugia Michael J. | Method for uniform application of fluid into a reactive reagent area |
JP2005024316A (en) * | 2003-06-30 | 2005-01-27 | Kyocera Corp | Microchemical chip and manufacturing method therefor |
US7347617B2 (en) * | 2003-08-19 | 2008-03-25 | Siemens Healthcare Diagnostics Inc. | Mixing in microfluidic devices |
RU2006110931A (en) * | 2003-09-05 | 2007-10-20 | Кайлипер Лайф Сайенсиз, Инк. (Us) | ANALYZED SUBSTANCE INJECTION SYSTEM |
US7867194B2 (en) | 2004-01-29 | 2011-01-11 | The Charles Stark Draper Laboratory, Inc. | Drug delivery apparatus |
WO2005072793A1 (en) * | 2004-01-29 | 2005-08-11 | The Charles Stark Draper Laboratory, Inc. | Implantable drug delivery apparatus |
US20060285433A1 (en) * | 2005-06-20 | 2006-12-21 | Jing-Tang Yang | Fluidic mixer of serpentine channel incorporated with staggered sudden-expansion and convergent cross sections |
WO2007024485A2 (en) * | 2005-08-11 | 2007-03-01 | Eksigent Technologies, Llc | Microfluidic reduction of diffusion and complience effect in a fluid mixing region |
US20070246106A1 (en) | 2006-04-25 | 2007-10-25 | Velocys Inc. | Flow Distribution Channels To Control Flow in Process Channels |
US9046192B2 (en) * | 2007-01-31 | 2015-06-02 | The Charles Stark Draper Laboratory, Inc. | Membrane-based fluid control in microfluidic devices |
JP2008212814A (en) * | 2007-03-02 | 2008-09-18 | Canon Inc | Fluid carrying passage, fluid treatment apparatus and fluid treatment system |
WO2008130977A2 (en) * | 2007-04-16 | 2008-10-30 | The General Hospital Corporation D/B/A Massachusetts General Hospital | Systems and methods for particle focusing in microchannels |
JP4411661B2 (en) * | 2007-10-26 | 2010-02-10 | セイコーエプソン株式会社 | Biological substance detection method |
US8430558B1 (en) * | 2008-09-05 | 2013-04-30 | University Of Central Florida Research Foundation, Inc. | Microfluidic mixer having channel width variation for enhanced fluid mixing |
US8377277B2 (en) | 2008-10-22 | 2013-02-19 | General Electric Company | System and method for performing microfluidic manipulation |
JP5008690B2 (en) | 2009-03-31 | 2012-08-22 | 信和化工株式会社 | Microchannel device and method for manufacturing microchannel device |
DE112010002222B4 (en) | 2009-06-04 | 2024-01-25 | Leidos Innovations Technology, Inc. (n.d.Ges.d. Staates Delaware) | Multi-sample microfluidic chip for DNA analysis |
CN103108701B (en) * | 2010-09-26 | 2015-03-11 | 大玉企业有限公司 | Separation of analytes |
US8961764B2 (en) | 2010-10-15 | 2015-02-24 | Lockheed Martin Corporation | Micro fluidic optic design |
EP2670456B1 (en) | 2011-02-02 | 2019-12-18 | The Charles Stark Draper Laboratory, Inc. | Drug delivery apparatus |
US8795605B2 (en) * | 2012-01-12 | 2014-08-05 | Fred C. Senftleber | Apparatus and methods for transferring materials between locations possessing different cross-sectional areas with minimal band spreading and dispersion due to unequal path-lengths |
US9322054B2 (en) | 2012-02-22 | 2016-04-26 | Lockheed Martin Corporation | Microfluidic cartridge |
CN102788831B (en) * | 2012-08-13 | 2014-07-30 | 中国科学院研究生院 | Microfluidic chip electrophoretic-electrochemical detecting device with adjustable pH after separation and use thereof |
US20140065034A1 (en) * | 2012-08-31 | 2014-03-06 | Yun Zheng | Microfluidic device and method of fabricating microfluidic devices |
CN106596692B (en) * | 2017-01-14 | 2018-12-28 | 常州大学 | A kind of method of tortuous capillary electrophoresis detection antibody polypeptides interaction |
WO2022241247A1 (en) * | 2021-05-13 | 2022-11-17 | Fluid-Screen, Inc. | Microfluidic device with improved flow profile |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0339780B1 (en) * | 1988-04-29 | 1996-08-28 | Beckman Instruments, Inc. | Capillary detector cartridge for electrophoresis |
JPH03223674A (en) * | 1989-11-30 | 1991-10-02 | Mochida Pharmaceut Co Ltd | Reaction vessel |
SE470347B (en) * | 1990-05-10 | 1994-01-31 | Pharmacia Lkb Biotech | Microstructure for fluid flow systems and process for manufacturing such a system |
EP0637997B1 (en) * | 1992-05-01 | 1998-07-01 | Trustees Of The University Of Pennsylvania | Analysis based on flow restriction |
DE59410283D1 (en) | 1993-11-11 | 2003-06-18 | Aclara Biosciences Inc | Device and method for the electrophoretic separation of fluid substance mixtures |
US6001229A (en) * | 1994-08-01 | 1999-12-14 | Lockheed Martin Energy Systems, Inc. | Apparatus and method for performing microfluidic manipulations for chemical analysis |
US5658413A (en) * | 1994-10-19 | 1997-08-19 | Hewlett-Packard Company | Miniaturized planar columns in novel support media for liquid phase analysis |
JP3839524B2 (en) * | 1995-06-07 | 2006-11-01 | アジレント・テクノロジーズ・インク | Miniaturized total analysis system |
US5993750A (en) * | 1997-04-11 | 1999-11-30 | Eastman Kodak Company | Integrated ceramic micro-chemical plant |
US5958694A (en) * | 1997-10-16 | 1999-09-28 | Caliper Technologies Corp. | Apparatus and methods for sequencing nucleic acids in microfluidic systems |
-
1998
- 1998-11-12 EP EP98958561A patent/EP1031032B1/en not_active Expired - Lifetime
- 1998-11-12 CA CA002307623A patent/CA2307623C/en not_active Expired - Fee Related
- 1998-11-12 US US09/191,417 patent/US6176991B1/en not_active Expired - Fee Related
- 1998-11-12 JP JP2000519780A patent/JP2001523001A/en active Pending
- 1998-11-12 AU AU14580/99A patent/AU747940B2/en not_active Ceased
- 1998-11-12 AT AT98958561T patent/ATE220456T1/en not_active IP Right Cessation
- 1998-11-12 DE DE69806499T patent/DE69806499T2/en not_active Expired - Lifetime
- 1998-11-12 WO PCT/US1998/024202 patent/WO1999024828A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
EP1031032B1 (en) | 2002-07-10 |
JP2001523001A (en) | 2001-11-20 |
AU1458099A (en) | 1999-05-31 |
ATE220456T1 (en) | 2002-07-15 |
AU747940B2 (en) | 2002-05-30 |
CA2307623C (en) | 2004-03-16 |
DE69806499T2 (en) | 2003-02-27 |
US6176991B1 (en) | 2001-01-23 |
DE69806499D1 (en) | 2002-08-14 |
WO1999024828A1 (en) | 1999-05-20 |
EP1031032A1 (en) | 2000-08-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |