CA2302044A1 - Treatment device for topical photodynamic therapy and method of making same - Google Patents

Treatment device for topical photodynamic therapy and method of making same Download PDF

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Publication number
CA2302044A1
CA2302044A1 CA002302044A CA2302044A CA2302044A1 CA 2302044 A1 CA2302044 A1 CA 2302044A1 CA 002302044 A CA002302044 A CA 002302044A CA 2302044 A CA2302044 A CA 2302044A CA 2302044 A1 CA2302044 A1 CA 2302044A1
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CA
Canada
Prior art keywords
light
light emitting
treatment device
liner
members
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002302044A
Other languages
French (fr)
Other versions
CA2302044C (en
Inventor
Merrill A. Biel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Advanced Photodynamic Technologies Inc
Original Assignee
Advanced Photodynamic Technologies, Inc.
Merrill A. Biel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Photodynamic Technologies, Inc., Merrill A. Biel filed Critical Advanced Photodynamic Technologies, Inc.
Publication of CA2302044A1 publication Critical patent/CA2302044A1/en
Application granted granted Critical
Publication of CA2302044C publication Critical patent/CA2302044C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00017—Electrical control of surgical instruments
    • A61B2017/00022—Sensing or detecting at the treatment site
    • A61B2017/00057—Light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N2005/002—Cooling systems
    • A61N2005/005—Cooling systems for cooling the radiator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N2005/002—Cooling systems
    • A61N2005/007—Cooling systems for cooling the patient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A61N5/0603—Apparatus for use inside the body for treatment of body cavities
    • A61N2005/0606—Mouth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
    • A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
    • A61N2005/0645—Applicators worn by the patient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/065—Light sources therefor
    • A61N2005/0651—Diodes
    • A61N2005/0652—Arrays of diodes

Landscapes

  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Radiation-Therapy Devices (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to a light emitting treatment device (10, 20, 30) including one or more light members which are configured to emit energy for photodynamic therapy of a body surface. The treatment device (10, 20, 30) is made of a polymeric material configured to conform to a body surface. The light members may be disposed in a substantially uniform array, and be configured to emit energy in a substantially uniform pattern. The light emitting treatment device (10, 20, 30) may further include a heat dissipating layer, a layer of gold or gold alloy, or a layer of adhesive disposed on at least one of the one or more surfaces of the shell or liner. Methods of making, and using the treatment device are also disclosed.

Claims (29)

1. A light emitting treatment device comprising:
a shell having one or more surfaces;
a liner having one or more surfaces, the liner at least partially disposed in the shell; and one or more light members disposed in at least one of the liner or the shell wherein the shell, the Liner material and the one or more light members form an assembly and the one or more light members are configured to emit energy from the assembly for photodynamic therapy of a body surface.
2. The light emitting treatment device of claim 1 wherein the shell and liner are made of a polymeric material.
3. The light emitting treatment device of claim 1 wherein the treatment device is at least one of substantially flexible and conformable to a body surface or substantially rigid and conformable to a body surface.
4. The light emitting treatment device of claim 1 wherein the light members are disposed in a substantially uniform array.
5. The light emitting treatment device of claim 1 wherein the one or more light members are configured to emit energy in a substantially uniform pattern.
6. The light emitting treatment device of claim 1 wherein at least one of the shell or the liner is made of a gel.
7. The light emitting treatment device of claim 1 wherein the shell and the liner are configured in a substantially integral structure.
8. The Light emitting treatment device of claim 1 further comprising a heat dissipating layer disposed on at least one of the one or more surfaces.
9. The light emitting treatment device of claim 1 further comprising a layer of gold or gold alloy disposed on the one or more surfaces.
10. The light emitting treatment device of claim 1 wherein the one or more light members are configured in a light diffusing layer.
11. The light emitting treatment device of claim 1 further comprising an adhesive disposed on at least one outside surface of the treatment device.
12. A light emitting treatment device comprising:
a shell having one or more surfaces and made of a polymer;
a liner including a gel, the liner having one or more surfaces and made of a polymer, the liner at least partially disposed in the shell; and one or more light members disposed in an array in at least one of the liner or the shell wherein the shell, the liner material and the one or more light members form an assembly and the one or more light members are configured to emit energy from the assembly in a substantially uniform pattern for photodynamic therapy;
a heat dissipating layer associated with the assembly; and a layer of gold material associated with an outside surface of the assembly.
13. A light emitting device comprising:
a shaped member having one or more surfaces, the shaped member configured to be juxtaposed one or more body surfaces in a mouth; and one or more light members disposed in the shaped member, the one or more light members configured to emit energy to the one or more body surfaces for photodynamic therapy.
14. The light emitting device of claim 13 further comprising a remote light source operatively coupled to the shaped member via at least one of a fiber optic element, a plurality of internally embedded filaments, and one or more VCSELs.
15. The light emitting device of claim 13 wherein the shaped member includes a gel having light diffusing characteristics.
16. The light emitting device of claim 13 wherein the shaped member is configured to treat a gum line for a disease.
17. The light emitting device of claim 13 wherein the one or more light members are embedded in the shaped member.
18. The light emitting device of claim 13 wherein the shaped member is made of a polymer.
19. The light emitting device of claim 13 wherein the shaped member further comprises a control operatively coupled to the shaped member to provide at least one of a range of intensity or selective operation of the emitted energy.
20. A method of forming a light emitting treatment device comprising the steps of:
forming a shell having one or more surfaces;
forming a liner having one or more surfaces;
disposing one or more light members in the liner material; and disposing the liner at least partially in the shell wherein the shell, the liner material and the one or more light members form an assembly and the one or more light members are configured to emit energy at a treatment site.
21. A product made from the method of forming a light emitting treatment patch comprising the steps of:

forming a member having one or more surfaces; and disposing one or more light members in the member wherein the member and the one or more light members form an assembly and the one or more light members are configured to emit energy at a treatment site for photodynamic therapy.
22. A method of using a light emitting treatment device comprising the steps of:
identifying an area of treatment on a body surface;
applying a surface of a light emitting treatment device having a liner and one or more light members disposed in the liner on the area of treatment, the liner and the one or more light members forming an assembly, the one or more light members configured to emit energy at the area of treatment;

activating a light transmitting source for a period of time such that the one or more light members emit energy at the area of treatment for photodynamic therapy.
23. The method of using a light emitting treatment device of claim 22 further comprising injecting a drug through the treatment device into the body.
24. A product made from the process of forming a light emitting treatment device comprising the steps of:
forming a mold;
pouring a material into a recess defined by the mold, the material configured in substantially viscous liquid state;
disposing one or more filaments in the mold prior to adding the material or embedding the one or more filaments within the material after it has been poured into the recess defined by the mold, curing or drying the material such that the material and the one or more filaments form a treatment device.
25. The product made from the process of forming a light emitting treatment device of claim 24 further comprising the step of:
curing the material at an ambient temperature or at an elevated temperature.
26. A light emitting treatment device comprising:
a member having a thickness and one or more surfaces, the member configured to conform to one or more body surfaces; and one or more light members disposed in the member;
wherein the member and the one or more light members form an assembly and the one or more light members are configured to emit energy from the assembly for photodynamic therapy of the one or more body surfaces.
27. The light emitting treatment device of claim 26 wherein the member includes one or more light detectors configured to provide surface monitoring.
28. The light emitting treatment device of claim 27 wherein the surface monitoring includes at least one of light wavelength (nm), light dosage (joules/cm2), or light dosage rate (mw/cm2).
29. The light emitting treatment device of claim 26 wherein the light emitting treatment device provides light wavelengths ranging from about 450nm to about 850nm; a light dosage rate ranging from about 0 mw/cm2 to about 150 mw/cm2; and a light dose ranging from 0 J/cm2 to about 300 J/cm2.
CA2302044A 1997-08-25 1998-08-25 Treatment device for topical photodynamic therapy and method of making same Expired - Lifetime CA2302044C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US5735697P 1997-08-25 1997-08-25
US60/057,356 1997-08-25
PCT/US1998/017589 WO1999010046A1 (en) 1997-08-25 1998-08-25 Treatment device for topical photodynamic therapy and method of making same
US09/513,573 US6743249B1 (en) 1997-08-25 2000-02-25 Treatment device for photodynamic therapy and method for making same

Publications (2)

Publication Number Publication Date
CA2302044A1 true CA2302044A1 (en) 1999-03-04
CA2302044C CA2302044C (en) 2011-07-05

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA2302044A Expired - Lifetime CA2302044C (en) 1997-08-25 1998-08-25 Treatment device for topical photodynamic therapy and method of making same

Country Status (7)

Country Link
US (2) US6743249B1 (en)
EP (1) EP1009483B1 (en)
AT (1) ATE313353T1 (en)
AU (1) AU9294298A (en)
CA (1) CA2302044C (en)
DE (1) DE69832888T2 (en)
WO (1) WO1999010046A1 (en)

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