CA2301018A1 - Hyaluronic acid gel, method of its production and medical material containing it - Google Patents

Hyaluronic acid gel, method of its production and medical material containing it Download PDF

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Publication number
CA2301018A1
CA2301018A1 CA002301018A CA2301018A CA2301018A1 CA 2301018 A1 CA2301018 A1 CA 2301018A1 CA 002301018 A CA002301018 A CA 002301018A CA 2301018 A CA2301018 A CA 2301018A CA 2301018 A1 CA2301018 A1 CA 2301018A1
Authority
CA
Canada
Prior art keywords
hyaluronic acid
material containing
medical material
production
acid gel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002301018A
Other languages
French (fr)
Other versions
CA2301018C (en
Inventor
Yoshiaki Miyata
Akio Okamoto
Masatoshi Kawata
Kazuhiro Oshima
Masamichi Hashimoto
Kazuhiko Arai
Tomio Sawada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Denka Co Ltd
Original Assignee
Denki Kagaku Kogyo Kabushiki Kaisha
Yoshiaki Miyata
Akio Okamoto
Masatoshi Kawata
Kazuhiro Oshima
Masamichi Hashimoto
Kazuhiko Arai
Tomio Sawada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Denki Kagaku Kogyo Kabushiki Kaisha, Yoshiaki Miyata, Akio Okamoto, Masatoshi Kawata, Kazuhiro Oshima, Masamichi Hashimoto, Kazuhiko Arai, Tomio Sawada filed Critical Denki Kagaku Kogyo Kabushiki Kaisha
Publication of CA2301018A1 publication Critical patent/CA2301018A1/en
Application granted granted Critical
Publication of CA2301018C publication Critical patent/CA2301018C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/042—Polysaccharides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates

Abstract

A gel of hyaluronic acid (1) alone, characterized by being difficultly soluble in neutral aqueous solutions, and (2) a medical material containing the hyaluronic acid gel (1), characterized by keeping its shape in a neutral aqueous solution at a temperature of 25 °C for one day or longer.
CA002301018A 1997-08-22 1998-08-07 Hyaluronic acid gel, method of its production and medical material containing it Expired - Fee Related CA2301018C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP22673497 1997-08-22
JP9-226734 1997-08-22
JP11756498 1998-04-27
JP10-117564 1998-04-27
PCT/JP1998/003536 WO1999010385A1 (en) 1997-08-22 1998-08-07 Hyaluronic acid gel, process for producing the same and medical material containing the same

Publications (2)

Publication Number Publication Date
CA2301018A1 true CA2301018A1 (en) 1999-03-04
CA2301018C CA2301018C (en) 2006-06-20

Family

ID=26455658

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002301018A Expired - Fee Related CA2301018C (en) 1997-08-22 1998-08-07 Hyaluronic acid gel, method of its production and medical material containing it

Country Status (11)

Country Link
US (2) US6387413B1 (en)
EP (1) EP1005874B1 (en)
JP (1) JP3359909B2 (en)
KR (1) KR100374666B1 (en)
CN (1) CN1101405C (en)
AT (1) ATE295745T1 (en)
AU (1) AU742675B2 (en)
CA (1) CA2301018C (en)
DE (1) DE69830240T2 (en)
NZ (1) NZ502815A (en)
WO (1) WO1999010385A1 (en)

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Also Published As

Publication number Publication date
CN1267308A (en) 2000-09-20
KR20010023185A (en) 2001-03-26
EP1005874A4 (en) 2001-02-07
WO1999010385A1 (en) 1999-03-04
AU742675B2 (en) 2002-01-10
KR100374666B1 (en) 2003-03-04
US6387413B1 (en) 2002-05-14
DE69830240D1 (en) 2005-06-23
US6790461B2 (en) 2004-09-14
DE69830240T2 (en) 2005-10-13
EP1005874A1 (en) 2000-06-07
ATE295745T1 (en) 2005-06-15
JP3359909B2 (en) 2002-12-24
CA2301018C (en) 2006-06-20
AU8561698A (en) 1999-03-16
EP1005874B1 (en) 2005-05-18
NZ502815A (en) 2002-03-01
CN1101405C (en) 2003-02-12
US20020098244A1 (en) 2002-07-25

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