CA2287469A1 - Interactive system for presenting and eliminating substances - Google Patents

Interactive system for presenting and eliminating substances Download PDF

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Publication number
CA2287469A1
CA2287469A1 CA002287469A CA2287469A CA2287469A1 CA 2287469 A1 CA2287469 A1 CA 2287469A1 CA 002287469 A CA002287469 A CA 002287469A CA 2287469 A CA2287469 A CA 2287469A CA 2287469 A1 CA2287469 A1 CA 2287469A1
Authority
CA
Canada
Prior art keywords
interactive system
substance
liquid
linker
food
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002287469A
Other languages
French (fr)
Other versions
CA2287469C (en
Inventor
Elke Bucha
Gotz Nowak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2287469A1 publication Critical patent/CA2287469A1/en
Application granted granted Critical
Publication of CA2287469C publication Critical patent/CA2287469C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0081—After-treatment of organic or inorganic membranes
    • B01D67/0093—Chemical modification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/14—Dynamic membranes
    • B01D69/141—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/14—Dynamic membranes
    • B01D69/141—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes
    • B01D69/1411—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes containing dispersed material in a continuous matrix
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/40—Polymers of unsaturated acids or derivatives thereof, e.g. salts, amides, imides, nitriles, anhydrides, esters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/40—Polymers of unsaturated acids or derivatives thereof, e.g. salts, amides, imides, nitriles, anhydrides, esters
    • B01D71/401—Polymers based on the polymerisation of acrylic acid, e.g. polyacrylate
    • B01D71/4011—Polymethylmethacrylate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
    • C08G81/02—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers at least one of the polymers being obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25125—Digestion or removing interfering materials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction

Abstract

The present invention relates to an interactive system comprising at least one active surface of plastic from monomers containing at least one structural element derived from a carbon dioxide (A), and at least one substance associated to a linker with at least one structural element (B) capable of establishing a hydrogen bond, and involving an interaction between the structural elements (A) and (B). That interactive system is suitable for presenting and eliminating substances in liquids.

Claims (33)

1. Interactive system comprising:
(a) one surface of a plastic material from monomers containing at least one structural element (A) derived from a carboxylic acid, (b) a linker with at least one structural element (B) capable of establishing a hydrogen bond, and (c) a substance coupled to the linker, wherein a stable interaction exists between the surface and the linker which comprises hydrogen bonds and which cannot be reversed by pH values in the range of from 2 to 13 or temperatures up to 60°C.
2. Interactive system according to claim 1, wherein the structural element derived from a carboxylic acid is located in a side chain of the monomer.
3. Interactive system according to claim 1 or 2, wherein the plastic material is a plastic material from a polymethacrylate, a polyvinylester or a copolymer, or a mixture thereof with other polymerizable substances.
4. Interactive system according to any of claims 1 to 3, wherein the linker is selected from (poly)alkylene glycols, (poly)alkylene imines, (poly)alkylene amines and (poly)alkylene sulfides.
5. Interactive system according to any of claims 1 to 4, wherein the active surface is a membrane, a porous or solid microparticle, a magnetic microparticle, a filter mat, a fibrous material, a spun material or a combination thereof, or a coating made from a natural or synthetic substance.
6. Interactive system according to any of claims 1 to 5, wherein the system is present in the form of a capillary tube system, a filter for physiological liquids, a dialyzer, a physiological replacement fluid, an enzyme delivery system, an arthroplasty or vascular prosthesis, or an artificial organ.
7. Interactive system according to any of claims 1 to 6, wherein the coupled substance is a physiologically and/or pharmacologically active substance.
8. Interactive system according to claim 7, wherein the active substance is a protein, a nucleic acid, a cellular signal substance, a partner of a biological or physiological affinity pair, a synthetic Ni-NTA complex, a synthetically produced pharmacon or a synthetically produced active ingredient or a marker for a biological or synthetic substance.
9. Interactive system according to claim 8, wherein the protein is selected from enzymes, antigens, antibodies, tumor markers, surface antigens, ligands, receptors, surface-active cell fragments of bacteria or viruses or immune messenger substances.
10. Interactive system according to claim 8, wherein the marker is a fluorescent or chemilumenescent substance, an EST (expression sequence code) or an enzyme.
11. Interactive system according to claim 7, wherein the active substance is an anticoagulant, a metabolically active enzyme, an antibiotic or a synthetic pharmacon.
12. Interactive system according to any of claims 1 to 11, wherein the plastic material is poly(meth)acrylate or a poly(meth)acrylate copolymer, the linker is polyethylene glycol and the coupled substance is an anticoagulant selected from heparin, hirudin, directly acting antithrombins or prothrombin.
13. Interactive system according to any of claims 1 to 11, wherein the plastic material is poly(meth)acrylate or a poly(meth)acrylate copolymer, the linker is polyethylene glycol and the coupled substance is an enzyme or a pharmaceutical composition.
14. Composition comprising an interactive system according to any of claims 1 to 13.
15. Composition according to claim 14 in the form of food, preferably a dietary food or designer food.
16. Composition according to claim 14 in the form of a pharmaceutical composition.
17. Use of an interactive system according to any of claims 1 of 11 as a system for presenting substances coupled to the linker in a liquid, wherein the target substance is bound, cleaved or otherwise modified by the coupled substance.
18. Use of an interactive system according to any of claims 1 to 11 for removing a substance coupled to the linker from a liquid.
19. Use according to claim 17 or 18, wherein the liquid is a biological liquid selected from whole blood, plasma, serum, urine, lymph, liquor, organ bioptate, enteral contents or sperm.
20. Use according to claim 17 or 18, wherein the liquid is food or a food component.
21. Use according to any of claims 17 to 19 as an extracorporal therapeutic or diagnostic system.
22. Use according to claim 21 for the diagnosis and therapy of metabolic diseases, coagulation defects, viral, bacterial, mycotic or parasitic infections or malignant diseases.
23. Use according to claim 20 for the manufacture of dietary food or designer food.
24. Use of an interactive system according to any of claims 1 to 13 for the production of assay systems.
25. Use according to claim 24 for the production of affinity columns, microtiter plates, ELISA test plates, microsticks, diagnostic sticks, hollow fibers or sheet materials.
26. Device comprising an interactive system according to any of claims 1 to 13 in a suitable housing, optionally together with an apparatus for operating the device.
27. Kit comprising an interactive system according to any of claims 1 to 13, optionally together with suitable reagents, buffer solutions and reaction vessels and optionally in a suitable packaging.
28. Method for treating a liquid, characterized in that the liquid to be treated is brought into contact with an interactive system according to any of claims 1 to 13 and that afterwards the thus treated liquid is separated again.
29. Method according to claim 28, characterized in that the liquid to be treated is blood, a blood component or a secondary blood product and that the interactive system comprises a substance reacting with a blood component.
30. Method according to claim 28, characterized in that the liquid to be treated is food and that the interactive system comprises a substance reacting with a food ingredient.
31. Interactive system according to any of claims 1 to 13 for the use as an agent for the treatment of metabolic diseases, coagulation defects, viral, bacterial, mycotic or parasitic infections or malignant diseases.
32. Interactive system according to any of claims 1 to 13 for preparing an agent for the treatment of metabolic diseases, coagulation defects, viral, bacterial, mycotic or parasitic infections or malignant diseases.
33. Method for the treatment of metabolic diseases, coagulation defects, viral, bacterial, mycotic or parasitic infections or malignant diseases comprising administering to the patient to be treated an interactive system according to any of claims 1 to 13 in a suitable manner.
CA2287469A 1997-04-14 1998-04-14 Interactive system for presenting and eliminating substances Expired - Fee Related CA2287469C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19715504A DE19715504C2 (en) 1997-04-14 1997-04-14 PMMA membranes with polyethylene glycol-coupled active substances
DE19715504.9 1997-04-14
PCT/EP1998/002183 WO1998046648A1 (en) 1997-04-14 1998-04-14 Interactive system for substance presentation and elimination

Publications (2)

Publication Number Publication Date
CA2287469A1 true CA2287469A1 (en) 1998-10-22
CA2287469C CA2287469C (en) 2010-02-09

Family

ID=7826448

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2287469A Expired - Fee Related CA2287469C (en) 1997-04-14 1998-04-14 Interactive system for presenting and eliminating substances

Country Status (9)

Country Link
US (2) US6929955B2 (en)
EP (2) EP1921094A3 (en)
JP (1) JP4495258B2 (en)
AT (1) ATE380202T1 (en)
AU (1) AU7525498A (en)
CA (1) CA2287469C (en)
DE (2) DE19715504C2 (en)
ES (1) ES2297886T3 (en)
WO (1) WO1998046648A1 (en)

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Also Published As

Publication number Publication date
US6929955B2 (en) 2005-08-16
EP1921094A2 (en) 2008-05-14
US20020028201A1 (en) 2002-03-07
ES2297886T3 (en) 2008-05-01
JP2001527539A (en) 2001-12-25
EP1921094A3 (en) 2009-06-24
WO1998046648A1 (en) 1998-10-22
EP0975680A1 (en) 2000-02-02
DE59814134D1 (en) 2008-01-17
ATE380202T1 (en) 2007-12-15
DE19715504C2 (en) 2000-10-26
AU7525498A (en) 1998-11-11
EP0975680B1 (en) 2007-12-05
US7494824B2 (en) 2009-02-24
JP4495258B2 (en) 2010-06-30
US20050239131A1 (en) 2005-10-27
DE19715504A1 (en) 1998-10-15
CA2287469C (en) 2010-02-09

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