CA2282416A1 - Light sensing device - Google Patents

Light sensing device Download PDF

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Publication number
CA2282416A1
CA2282416A1 CA002282416A CA2282416A CA2282416A1 CA 2282416 A1 CA2282416 A1 CA 2282416A1 CA 002282416 A CA002282416 A CA 002282416A CA 2282416 A CA2282416 A CA 2282416A CA 2282416 A1 CA2282416 A1 CA 2282416A1
Authority
CA
Canada
Prior art keywords
light
scanning
sample
fields
deflection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002282416A
Other languages
French (fr)
Other versions
CA2282416C (en
Inventor
Jurgen Wulf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PE Manufacturing GmbH
Original Assignee
Bodenseewerk Perkin-Elmer Gmbh
Jurgen Wulf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bodenseewerk Perkin-Elmer Gmbh, Jurgen Wulf filed Critical Bodenseewerk Perkin-Elmer Gmbh
Publication of CA2282416A1 publication Critical patent/CA2282416A1/en
Application granted granted Critical
Publication of CA2282416C publication Critical patent/CA2282416C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B26/00—Optical devices or arrangements for the control of light using movable or deformable optical elements
    • G02B26/08—Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light
    • G02B26/10—Scanning systems
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B26/00—Optical devices or arrangements for the control of light using movable or deformable optical elements
    • G02B26/08—Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light
    • G02B26/10—Scanning systems
    • G02B26/101—Scanning systems with both horizontal and vertical deflecting means, e.g. raster or XY scanners
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/10—Beam splitting or combining systems
    • G02B27/14—Beam splitting or combining systems operating by reflection only
    • G02B27/148—Beam splitting or combining systems operating by reflection only including stacked surfaces having at least one double-pass partially reflecting surface

Abstract

The present invention relates to a light scanning device for exciting and detecting an emission of secondary light, especially fluorescent light, of a sample, comprising a light generating device for generating scanning light in the form of a single light beam, a deflection unit used for effecting a deflection of the scanning light for scanning at least one subarea of the sample, said deflection being variable in at least one direction, an imaging unit for forming an image of the secondary light emanating from the sample, and a detection unit for detecting the secondary light. When a sample with a large surface to be rastered is subjected to fluorescence examination with high spatial resolution, undesirably long scanning times occur. For reducing the scanning time and for simultaneously maintaining the high resolution in the case of such a sample, the light scanning device according to the present invention comprises a division device for dividing the single light beam into at least two light beams. This has the effect that, instead of the former sequential scanning of the sample, a subdivision into fields is carried out, said fields being scanned simultaneously by the plurality of light beams. The scanning time can therefore be reduced in accordance with the number of the simultaneously scanned fields of the sample.
CA002282416A 1997-02-24 1997-12-04 Light sensing device Expired - Fee Related CA2282416C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19707227A DE19707227A1 (en) 1997-02-24 1997-02-24 Light scanner
DE19707227.5 1997-02-24
PCT/EP1997/006794 WO1998038542A1 (en) 1997-02-24 1997-12-04 Light sensing device

Publications (2)

Publication Number Publication Date
CA2282416A1 true CA2282416A1 (en) 1998-09-03
CA2282416C CA2282416C (en) 2002-11-19

Family

ID=7821243

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002282416A Expired - Fee Related CA2282416C (en) 1997-02-24 1997-12-04 Light sensing device

Country Status (7)

Country Link
US (1) US6229635B1 (en)
EP (1) EP0961945B1 (en)
JP (1) JP3330617B2 (en)
AU (1) AU5659598A (en)
CA (1) CA2282416C (en)
DE (2) DE19707227A1 (en)
WO (1) WO1998038542A1 (en)

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US6455861B1 (en) 1998-11-24 2002-09-24 Cambridge Research & Instrumentation, Inc. Fluorescence polarization assay system and method
US6937330B2 (en) 1999-04-23 2005-08-30 Ppd Biomarker Discovery Sciences, Llc Disposable optical cuvette cartridge with low fluorescence material
US7387891B2 (en) * 1999-05-17 2008-06-17 Applera Corporation Optical instrument including excitation source
US20050279949A1 (en) * 1999-05-17 2005-12-22 Applera Corporation Temperature control for light-emitting diode stabilization
US6687395B1 (en) * 1999-07-21 2004-02-03 Surromed, Inc. System for microvolume laser scanning cytometry
US6784982B1 (en) 1999-11-04 2004-08-31 Regents Of The University Of Minnesota Direct mapping of DNA chips to detector arrays
US6867851B2 (en) * 1999-11-04 2005-03-15 Regents Of The University Of Minnesota Scanning of biological samples
WO2001063261A1 (en) 2000-02-25 2001-08-30 Cambridge Research & Instrumentation Inc. Automatic g-factor calibration
US6787761B2 (en) * 2000-11-27 2004-09-07 Surromed, Inc. Median filter for liquid chromatography-mass spectrometry data
CA2429824A1 (en) * 2000-11-28 2002-06-06 Surromed, Inc. Methods for efficiently mining broad data sets for biological markers
WO2002093144A1 (en) * 2001-05-10 2002-11-21 Regents Of The University Of Minnesota Imaging of biological samples using electronic light detector
US6873915B2 (en) * 2001-08-24 2005-03-29 Surromed, Inc. Peak selection in multidimensional data
US20030078739A1 (en) * 2001-10-05 2003-04-24 Surromed, Inc. Feature list extraction from data sets such as spectra
DE10151216A1 (en) * 2001-10-16 2003-04-24 Zeiss Carl Jena Gmbh Method for the optical detection of characteristic quantities of an illuminated sample
US6989100B2 (en) * 2002-05-09 2006-01-24 Ppd Biomarker Discovery Sciences, Llc Methods for time-alignment of liquid chromatography-mass spectrometry data
WO2004019277A1 (en) * 2002-08-20 2004-03-04 Cyvera Corporation Diffraction grating-based encoded micro-particles for multiplexed experiments
US7126755B2 (en) * 2002-09-12 2006-10-24 Moon John A Method and apparatus for labeling using diffraction grating-based encoded optical identification elements
US7872804B2 (en) 2002-08-20 2011-01-18 Illumina, Inc. Encoded particle having a grating with variations in the refractive index
US7508608B2 (en) 2004-11-17 2009-03-24 Illumina, Inc. Lithographically fabricated holographic optical identification element
EP1535241A1 (en) * 2002-08-20 2005-06-01 Cyvera Corporation Diffraction grating-based optical identification element
US7923260B2 (en) 2002-08-20 2011-04-12 Illumina, Inc. Method of reading encoded particles
US7164533B2 (en) 2003-01-22 2007-01-16 Cyvera Corporation Hybrid random bead/chip based microarray
US7900836B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Optical reader system for substrates having an optically readable code
US7901630B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Diffraction grating-based encoded microparticle assay stick
US7092160B2 (en) 2002-09-12 2006-08-15 Illumina, Inc. Method of manufacturing of diffraction grating-based optical identification element
CA2498913A1 (en) * 2002-09-12 2004-03-25 Cyvera Corporation Assay stick comprising coded microbeads
CA2498933C (en) * 2002-09-12 2012-08-28 Cyvera Corporation Method and apparatus for aligning elongated microbeads in order to interrogate the same
US20100255603A9 (en) 2002-09-12 2010-10-07 Putnam Martin A Method and apparatus for aligning microbeads in order to interrogate the same
EP1540591A1 (en) * 2002-09-12 2005-06-15 Cyvera Corporation Diffraction grating-based encoded micro-particles for multiplexed experiments
WO2004025561A1 (en) * 2002-09-12 2004-03-25 Cyvera Corporation Chemical synthesis using diffraction grating-based encoded optical elements
DE60214561T2 (en) * 2002-10-17 2007-05-16 Direvo Biotech Ag Fluorimetric multi-parameter analysis in a parallel multi-focus arrangement
US7170598B2 (en) * 2002-10-17 2007-01-30 Direvo Biotech Ag Multi-parameter fluorimetric analysis in a massively parallel multi-focal arrangement and the use thereof
US6961126B2 (en) * 2003-10-23 2005-11-01 Honeywell International Inc. Optical wavelength splitter
US7433123B2 (en) 2004-02-19 2008-10-07 Illumina, Inc. Optical identification element having non-waveguide photosensitive substrate with diffraction grating therein
US7248360B2 (en) 2004-04-02 2007-07-24 Ppd Biomarker Discovery Sciences, Llc Polychronic laser scanning system and method of use
WO2006020363A2 (en) 2004-07-21 2006-02-23 Illumina, Inc. Method and apparatus for drug product tracking using encoded optical identification elements
EP2194485B1 (en) 2004-11-16 2012-10-17 Illumina, Inc. Method and apparatus for reading coded microbeads
US7329860B2 (en) * 2005-11-23 2008-02-12 Illumina, Inc. Confocal imaging methods and apparatus
US7830575B2 (en) 2006-04-10 2010-11-09 Illumina, Inc. Optical scanner with improved scan time
US7813013B2 (en) * 2006-11-21 2010-10-12 Illumina, Inc. Hexagonal site line scanning method and system
US7791013B2 (en) * 2006-11-21 2010-09-07 Illumina, Inc. Biological microarray line scanning method and system
US20080150897A1 (en) * 2006-12-22 2008-06-26 Timothy Lin Optical structure for a laser input device
DE202008018428U1 (en) * 2007-10-22 2013-10-09 Tecan Trading Ag Slide transporter for a laser scanner device

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US4268110A (en) * 1979-10-12 1981-05-19 Itek Corporation Facet angle corrector for multi-faceted optical scanner
GB9015793D0 (en) * 1990-07-18 1990-09-05 Medical Res Council Confocal scanning optical microscope
US5239178A (en) * 1990-11-10 1993-08-24 Carl Zeiss Optical device with an illuminating grid and detector grid arranged confocally to an object
US5272715A (en) * 1992-08-21 1993-12-21 Xerox Corporation Multi-beam laser diode beam separation control
WO1994018592A1 (en) * 1993-02-08 1994-08-18 Optiscan Pty Ltd Acn 060 658 754 Confocal microscope

Also Published As

Publication number Publication date
US6229635B1 (en) 2001-05-08
DE59712817D1 (en) 2007-03-29
AU5659598A (en) 1998-09-18
EP0961945B1 (en) 2007-02-14
CA2282416C (en) 2002-11-19
JP3330617B2 (en) 2002-09-30
JP2000509850A (en) 2000-08-02
EP0961945A1 (en) 1999-12-08
WO1998038542A1 (en) 1998-09-03
DE19707227A1 (en) 1998-08-27

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