CA2276789C - Implantable surgical marker - Google Patents
Implantable surgical marker Download PDFInfo
- Publication number
- CA2276789C CA2276789C CA002276789A CA2276789A CA2276789C CA 2276789 C CA2276789 C CA 2276789C CA 002276789 A CA002276789 A CA 002276789A CA 2276789 A CA2276789 A CA 2276789A CA 2276789 C CA2276789 C CA 2276789C
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- marker
- tissue
- legs
- camming
- transition
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- 239000003550 marker Substances 0.000 title claims abstract description 121
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- 230000003902 lesion Effects 0.000 abstract description 38
- 238000000034 method Methods 0.000 abstract description 32
- 238000001574 biopsy Methods 0.000 abstract description 18
- 230000002159 abnormal effect Effects 0.000 abstract description 10
- 210000000481 breast Anatomy 0.000 abstract description 9
- 230000035515 penetration Effects 0.000 abstract description 4
- 210000001519 tissue Anatomy 0.000 description 58
- 238000003384 imaging method Methods 0.000 description 7
- 238000001356 surgical procedure Methods 0.000 description 7
- 206010028980 Neoplasm Diseases 0.000 description 5
- 239000011324 bead Substances 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 208000004434 Calcinosis Diseases 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 230000009747 swallowing Effects 0.000 description 4
- 206010006187 Breast cancer Diseases 0.000 description 3
- 208000026310 Breast neoplasm Diseases 0.000 description 3
- 230000002308 calcification Effects 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 238000002595 magnetic resonance imaging Methods 0.000 description 3
- 230000005012 migration Effects 0.000 description 3
- 238000013508 migration Methods 0.000 description 3
- 230000001613 neoplastic effect Effects 0.000 description 3
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- 230000017531 blood circulation Effects 0.000 description 2
- 231100000504 carcinogenesis Toxicity 0.000 description 2
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- 230000034994 death Effects 0.000 description 2
- 231100000517 death Toxicity 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
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- 239000007924 injection Substances 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 238000011351 state-of-the-art imaging technique Methods 0.000 description 2
- 238000012285 ultrasound imaging Methods 0.000 description 2
- 208000019505 Deglutition disease Diseases 0.000 description 1
- 206010019909 Hernia Diseases 0.000 description 1
- 102000010029 Homer Scaffolding Proteins Human genes 0.000 description 1
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- 229910000831 Steel Inorganic materials 0.000 description 1
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- 238000004458 analytical method Methods 0.000 description 1
- 210000000709 aorta Anatomy 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 210000004351 coronary vessel Anatomy 0.000 description 1
- 230000009748 deglutition Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001861 endoscopic biopsy Methods 0.000 description 1
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- 239000012530 fluid Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 230000002962 histologic effect Effects 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000007386 incisional biopsy Methods 0.000 description 1
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- 238000002355 open surgical procedure Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/064—Surgical staples, i.e. penetrating the tissue
- A61B17/0644—Surgical staples, i.e. penetrating the tissue penetrating the tissue, deformable to closed position
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/068—Surgical staplers, e.g. containing multiple staples or clamps
- A61B17/0682—Surgical staplers, e.g. containing multiple staples or clamps for applying U-shaped staples or clamps, e.g. without a forming anvil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
- A61B2090/3904—Markers, e.g. radio-opaque or breast lesions markers specially adapted for marking specified tissue
- A61B2090/3908—Soft tissue, e.g. breast tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
- A61B2090/3987—Applicators for implanting markers
Abstract
An implantable marker for implantation in tissue of a surgical patient is disclosed. The marker has a base and an elevated bridge. A pair of legs descend from first and second transitions of the bridge. Each leg has a distal tip, a generally straight leg arm adjacent the tip, and a camming marker surface between the transitions of the base and the straight leg arm. The camming marker surfaces extend outwardly from the straight leg arms of the legs. In its open configuration, the first and second straight leg arms of the legs of the marker are generally parallel to each other. In its closed configuration, the first and second straight leg arms converge towards each other, and a marker apex is formed at the distal tips of the legs. The marker is particularly adapted for fixation in tissue to mark the site of a lesion or other abnormal tissue which may be removed during a biopsy procedure, for example a breast biopsy procedure. Advantageously, the camming marker surfaces of the legs of the marker facilitate the ability to form the marker upon pushing the marker distally into the tissue, thus insuring deep penetration of the marker and the grasping of a sufficient amount of tissue to securely fix the marker to the tissue.
Description
1N[PLANTABLE SURGICAL MARKER
Background of the Invention This invention relates to a niarker for iniplantation in tissue of a surgical patent. More specifically, it relates to an implantable marker for defining particular locations in human tissue, particularly in a human breast.
One in nine American women will develop breast cancer in their lifetime. It is the leading cause of cancer deaths in wonien 40-55 years of age and the second leading cause of cancer deaths in women overall. Breast cancer will be diagnosed in approxiniately one in eight women in their lifetinie, and one in 30 will die of this disease. Breast cancer does occur in males but is nluch less common. Biopsy requests stem from a screening process generally performed via a physical examination (palpable) and/or mammogram (non-palpable). A biopsy is indicated if suspicious tissue is detected. Five out of six biopsies performed return benign indications.
It is desirable and often ilecessary to perform procedures for detecting, sampling, and testing lesions and other abnormalities in the tissue of humans and other aninials, particularly in the diagnosis and treatnient of patients with cancerous tunlors, pre-nialignant condition and other diseases or disorders. Typically, in the case of cancer, when a physician establishes by means of known procedures (i.e.
palpation, x-ray, MRI, or ultrasound iniaging) that suspicious circumstances exist, a biopsy is performed to determine whether the cells are cancerous. Biopsy may be an open or percutaneous technique. Open biopsy removes the entire mass (excisional biopsy) or a part of the mass (incisional biopsy). Percutaneous biopsy on the other hand is usually done with a needle-like instrument and may be either a fine needle aspiration (FNA) or a core biopsy. In FNA biopsy, very small needles are used to obtain individual cells or clusters of cells for cytologic examination. The cells may be prepared such as in a Papanicolaou (Pap) smear. In core biopsy, as the tenn suggests, a core or fragment of tissue is obtained for histologic examination, which may be done via a trozen section or paraffin section. The chief difference between FNA=and core biopsy is the size of the tissue sample taken. An imaging system liaving spectroscopic capabilities, such as the stereotactic guidance system described in U.S. Patent No. 5,240,011 is employed to guide the extraction instrument to the lesion.
io Depending on the procedure being perfonned, the saniple niay result in the suspicious lesion being partially or conipletely renioved. Visibility of the lesion by the imaging system -nay be hanipered because of the distortion created by the extraction process itself as well as associated bleeding in the surrounding tissues.
Althougli the lesion is removed and all fluids are continuously aspirated froni the extraction site, it is likely that the process will "cloud" the lesion, thus impairing exact recognition of its margins. This niakes it difficult to ensure that the entire lesion will be renioved.
Often, the lesion is merely a calcification derived from dead abnormal tissue, which may be cancerous or pre-cancerous, and it is desirable to remove only a sample of the lesion, rather than the entire lesion, to evaluate it. This is because such a lesion actually serves to niark or define the location of adjacent abnonnal tissue, so the physician does not wish to reniove the entire lesion and thereby lose a critical nieans for later relocating the affected tissue. One of the benefits to the patient fronl core biopsy is that the niass of the tissue taken is small.
However, oftentimes, either inadvertently or because the lesion is too small, the entire lesion is removed for evaluation, even though it is desirable to remove only a portion.
Then, if subseyuent analysis indicates the tissue to be malignant (nialignant tissue requires removal, days or weeks later, of tissue around the iminediate site of the original biopsy), it is difficult for the physician to determine the precise location of the lesion, in order to perform necessary additional procedures on adjacent potentially cancerous tissue. Additionally, even if the lesion is found to be benign, there will be no evidence of its location during future examinations, to mark the location of the previously removed calcification so that the affected tissue may be carefully monitored for future reoccurrence.
Thus, it would be of considerable benefit to be able to permanently mark the location or niargins of such a lesion prior to or imniediately after renioving the sample. Marking prior to removal would help to ensure that the entire lesion is excised, if desired. Alternatively, if the lesion were inadvertently removed in its entirety, marking the biopsy site imnlediately after the procedure would enable re-establishment of its location for future identiGcation.
A number of procedures and devices for marking and locating particular tissue locations are known in the prior art. For example, location wire guides, such as that described in U.S. Patent No. 5,221,269 to Miller et al, are well known for locating lesions, particularly in the breast. The device described by Miller comprises a tubular introducer needle and an attached wire guide, which has at its distal end a helical coil configuration for locking into position about the targeted lesion. The needle is introduced onto the breast and guided to the lesion site using an imaging system of a known type, for example, x-ray, ultrasound or magnetic resonance imaging (MRI), at which time the helical coil at the distal end is deployed about the lesion. Then, the needle may be removed from the wire guide, which rernains in a locked position distally about the lesion for guiding a surgeon down the wire to the lesion site during subsequent surgery. Wllile such a location system is effective, it is obviously intended and designed to be only temporary, and is removed once the surgery or other procedure has been completed.
Background of the Invention This invention relates to a niarker for iniplantation in tissue of a surgical patent. More specifically, it relates to an implantable marker for defining particular locations in human tissue, particularly in a human breast.
One in nine American women will develop breast cancer in their lifetime. It is the leading cause of cancer deaths in wonien 40-55 years of age and the second leading cause of cancer deaths in women overall. Breast cancer will be diagnosed in approxiniately one in eight women in their lifetinie, and one in 30 will die of this disease. Breast cancer does occur in males but is nluch less common. Biopsy requests stem from a screening process generally performed via a physical examination (palpable) and/or mammogram (non-palpable). A biopsy is indicated if suspicious tissue is detected. Five out of six biopsies performed return benign indications.
It is desirable and often ilecessary to perform procedures for detecting, sampling, and testing lesions and other abnormalities in the tissue of humans and other aninials, particularly in the diagnosis and treatnient of patients with cancerous tunlors, pre-nialignant condition and other diseases or disorders. Typically, in the case of cancer, when a physician establishes by means of known procedures (i.e.
palpation, x-ray, MRI, or ultrasound iniaging) that suspicious circumstances exist, a biopsy is performed to determine whether the cells are cancerous. Biopsy may be an open or percutaneous technique. Open biopsy removes the entire mass (excisional biopsy) or a part of the mass (incisional biopsy). Percutaneous biopsy on the other hand is usually done with a needle-like instrument and may be either a fine needle aspiration (FNA) or a core biopsy. In FNA biopsy, very small needles are used to obtain individual cells or clusters of cells for cytologic examination. The cells may be prepared such as in a Papanicolaou (Pap) smear. In core biopsy, as the tenn suggests, a core or fragment of tissue is obtained for histologic examination, which may be done via a trozen section or paraffin section. The chief difference between FNA=and core biopsy is the size of the tissue sample taken. An imaging system liaving spectroscopic capabilities, such as the stereotactic guidance system described in U.S. Patent No. 5,240,011 is employed to guide the extraction instrument to the lesion.
io Depending on the procedure being perfonned, the saniple niay result in the suspicious lesion being partially or conipletely renioved. Visibility of the lesion by the imaging system -nay be hanipered because of the distortion created by the extraction process itself as well as associated bleeding in the surrounding tissues.
Althougli the lesion is removed and all fluids are continuously aspirated froni the extraction site, it is likely that the process will "cloud" the lesion, thus impairing exact recognition of its margins. This niakes it difficult to ensure that the entire lesion will be renioved.
Often, the lesion is merely a calcification derived from dead abnormal tissue, which may be cancerous or pre-cancerous, and it is desirable to remove only a sample of the lesion, rather than the entire lesion, to evaluate it. This is because such a lesion actually serves to niark or define the location of adjacent abnonnal tissue, so the physician does not wish to reniove the entire lesion and thereby lose a critical nieans for later relocating the affected tissue. One of the benefits to the patient fronl core biopsy is that the niass of the tissue taken is small.
However, oftentimes, either inadvertently or because the lesion is too small, the entire lesion is removed for evaluation, even though it is desirable to remove only a portion.
Then, if subseyuent analysis indicates the tissue to be malignant (nialignant tissue requires removal, days or weeks later, of tissue around the iminediate site of the original biopsy), it is difficult for the physician to determine the precise location of the lesion, in order to perform necessary additional procedures on adjacent potentially cancerous tissue. Additionally, even if the lesion is found to be benign, there will be no evidence of its location during future examinations, to mark the location of the previously removed calcification so that the affected tissue may be carefully monitored for future reoccurrence.
Thus, it would be of considerable benefit to be able to permanently mark the location or niargins of such a lesion prior to or imniediately after renioving the sample. Marking prior to removal would help to ensure that the entire lesion is excised, if desired. Alternatively, if the lesion were inadvertently removed in its entirety, marking the biopsy site imnlediately after the procedure would enable re-establishment of its location for future identiGcation.
A number of procedures and devices for marking and locating particular tissue locations are known in the prior art. For example, location wire guides, such as that described in U.S. Patent No. 5,221,269 to Miller et al, are well known for locating lesions, particularly in the breast. The device described by Miller comprises a tubular introducer needle and an attached wire guide, which has at its distal end a helical coil configuration for locking into position about the targeted lesion. The needle is introduced onto the breast and guided to the lesion site using an imaging system of a known type, for example, x-ray, ultrasound or magnetic resonance imaging (MRI), at which time the helical coil at the distal end is deployed about the lesion. Then, the needle may be removed from the wire guide, which rernains in a locked position distally about the lesion for guiding a surgeon down the wire to the lesion site during subsequent surgery. Wllile such a location system is effective, it is obviously intended and designed to be only temporary, and is removed once the surgery or other procedure has been completed.
Other devices are known for marking external regions of a patient's skin.
For exaniple, U.S. Patent No. 5,192,270 to Carswell, Jr. discloses a syringe which dispenses a colorant to give a visual indication on the surface of the point at which an injection has or will be given. Similarly, U.S. Patent No. 5,147,307 to Gluck discloses a device which has patterning elenients for impressing a temporary mark in a patients skin, foi- guiding the location of an injection or the like. It is also known to tape or otherwise adliere a small metallic marker, e.g. a 3 millinieter dianieter lead sphere, on the skin of a human breast in order to deliileate the location of skin calcifications (see Homer et al, The Geographic Cluster of Microcalcifications of the io Breast, Surgery, Gynecology, & Obstetrics, December 1985). Obviously, however, none of these approaches are useful for marking and delineating internal tissue abnormalities, such as lesions or tumors.
Still another approach for marking potential lesions and tumors of the breast is described in U.S. Patent No. 4,080,959. In the described procedure, the skin of the portion of the body to be evaluated, such as the breasts, is coated with a heat sensitive color-responsive chemical, after which that portion of the body is heated with penetrating radiation sucli as diathermy. Then, the coated body portion is scanned for color clianges which would indicate liot spots beneath the skin surface.
These so-called hot spots may represent a tunior or lesion, which does not dissipate heat as rapidly because of its relatively poor blood circulation (about 1/20 of the blood flow througli normal body tissue). This niethod, of course, functions as a temporary diagnostic tool, rather than in a permanent means for delineating the location of a tumor or lesion.
A method of identifying and treating abnormal neoplastic tissue or pathogens within the body is described in U.S. Patent No. 4,649,151 to Doughety et al.
In this nletliod, a tumor-selective photosensitizing drug is introduced into a patient's body, where it is cleared from normal tissue faster than it is cleared from abnormal tissue.
For exaniple, U.S. Patent No. 5,192,270 to Carswell, Jr. discloses a syringe which dispenses a colorant to give a visual indication on the surface of the point at which an injection has or will be given. Similarly, U.S. Patent No. 5,147,307 to Gluck discloses a device which has patterning elenients for impressing a temporary mark in a patients skin, foi- guiding the location of an injection or the like. It is also known to tape or otherwise adliere a small metallic marker, e.g. a 3 millinieter dianieter lead sphere, on the skin of a human breast in order to deliileate the location of skin calcifications (see Homer et al, The Geographic Cluster of Microcalcifications of the io Breast, Surgery, Gynecology, & Obstetrics, December 1985). Obviously, however, none of these approaches are useful for marking and delineating internal tissue abnormalities, such as lesions or tumors.
Still another approach for marking potential lesions and tumors of the breast is described in U.S. Patent No. 4,080,959. In the described procedure, the skin of the portion of the body to be evaluated, such as the breasts, is coated with a heat sensitive color-responsive chemical, after which that portion of the body is heated with penetrating radiation sucli as diathermy. Then, the coated body portion is scanned for color clianges which would indicate liot spots beneath the skin surface.
These so-called hot spots may represent a tunior or lesion, which does not dissipate heat as rapidly because of its relatively poor blood circulation (about 1/20 of the blood flow througli normal body tissue). This niethod, of course, functions as a temporary diagnostic tool, rather than in a permanent means for delineating the location of a tumor or lesion.
A method of identifying and treating abnormal neoplastic tissue or pathogens within the body is described in U.S. Patent No. 4,649,151 to Doughety et al.
In this nletliod, a tumor-selective photosensitizing drug is introduced into a patient's body, where it is cleared from normal tissue faster than it is cleared from abnormal tissue.
After the drug clears normal tissue but before it has cleared abnormal neoplastic tissue, the abnormal neoplastic tissue may be located by the luminescence of the drug witliin the abnormal tissue. The fluorescence may be observed with low intensity light, sonie of which is within the drug's absorbency spectruni.
Once detected, the tissue niay be destroyed by further application of higher intensity light having a frequency witliin the absorbency spectrum of the drug. Of course, this method also is only a temporary nleans for marking the abnormal tissue.
Additionally, once the abiiormal tissue has been destroyed during treatment, the marker is destroyed as well.
It is also known to employ biocompatible dyes or stains to niark breast lesions. First, a syringe containing the colorant is guided to a detected lesion, using an imaging systeni. Later, during the extraction procedure, ttie surgeon harvests a tissue saniple from the stained tissue. However, while such staining techniques can be effective, it is difficult to precisely localize the stain. Also, the stains are difficult to detect flouoroscopically and nlay not always be permanent.
Additionally, it is known to implant niarkers directly into a patient's body using invasive surgical techniques. For example, during a coronary artery bypass graft (CABG), which of course constitutes open-heart surgery, it is common practice to surgically apply one or nlore metallic rings to the aorta at the site of the graft.
Tliis enables a practitioner to later return to the site of the graft by identifying the rings, for evaluative purposes. It is also conimon practice to mark a surgical site with staples, vascular clips, and the like, for the purpose of future evaluation of the site.
A technique has been described for the study of pharyngeal swallowing in dogs, which involves permanently implanting steel marker beads in the submucosa of the pharynx (S.S. Kranier et al, A Permanent Radiopaque Marker Technique for the Study of Pliaryngeal Swallowing of Dogs, Dysphagia, Vol. l, pp.163-167, 1987). The article posits that the radiographic study of these marker beads during swallowing on niany occasions over a substantial period of time provides a better understanding of the pharyngeal pliase of deglutition on hunians. In the described technique, the beads were deposited using a metallic needle cannula having an internal diameter slightly smaller than the hcads to be implanted. When suction was applied to the cannula, the bead sat firmly on the tip. Once the ball-tipped cannula was inserted through tissue, the suction was broken, thereby releasing the bead, and the cannula is withdrawn.
Of course, this technique was not adapted or intended to mark specific tissue sites, but rather to mark an entire region or structure of the body in order to evaluate anatomical niovements (i.e. swallowing nlotions). It also was not intended for use in humans.
Accordingly, what is needed is a method and device for non-surgically implanting potentially permanent nlarkers at the site of a lesion or other abnormal tissue, for the purpose of defining the margins of a lesion before it is removed and/or to establish its location after it has been removed. The markers should be easy to deploy and easily detected using state of the art imaging techniques.
A niethod of iinplanting markers directly into a patient's body using minimally invasive surgical tecliniques is described in Inteniational Patent No. WO
9608208A1 to Foerster et al. In this method, a clipping device is introduced to the lesion site by a tubular cannula. Once the clip is at the lesion site, an actuating means at the proximal end outside the patient deploys the clip into the tissue. This marking means can be used long term and can be imaged by niost imaging techniques. However, because of its small size, current ultrasound imaging systems are unable to detect it within the tissue.
Once detected, the tissue niay be destroyed by further application of higher intensity light having a frequency witliin the absorbency spectrum of the drug. Of course, this method also is only a temporary nleans for marking the abnormal tissue.
Additionally, once the abiiormal tissue has been destroyed during treatment, the marker is destroyed as well.
It is also known to employ biocompatible dyes or stains to niark breast lesions. First, a syringe containing the colorant is guided to a detected lesion, using an imaging systeni. Later, during the extraction procedure, ttie surgeon harvests a tissue saniple from the stained tissue. However, while such staining techniques can be effective, it is difficult to precisely localize the stain. Also, the stains are difficult to detect flouoroscopically and nlay not always be permanent.
Additionally, it is known to implant niarkers directly into a patient's body using invasive surgical techniques. For example, during a coronary artery bypass graft (CABG), which of course constitutes open-heart surgery, it is common practice to surgically apply one or nlore metallic rings to the aorta at the site of the graft.
Tliis enables a practitioner to later return to the site of the graft by identifying the rings, for evaluative purposes. It is also conimon practice to mark a surgical site with staples, vascular clips, and the like, for the purpose of future evaluation of the site.
A technique has been described for the study of pharyngeal swallowing in dogs, which involves permanently implanting steel marker beads in the submucosa of the pharynx (S.S. Kranier et al, A Permanent Radiopaque Marker Technique for the Study of Pliaryngeal Swallowing of Dogs, Dysphagia, Vol. l, pp.163-167, 1987). The article posits that the radiographic study of these marker beads during swallowing on niany occasions over a substantial period of time provides a better understanding of the pharyngeal pliase of deglutition on hunians. In the described technique, the beads were deposited using a metallic needle cannula having an internal diameter slightly smaller than the hcads to be implanted. When suction was applied to the cannula, the bead sat firmly on the tip. Once the ball-tipped cannula was inserted through tissue, the suction was broken, thereby releasing the bead, and the cannula is withdrawn.
Of course, this technique was not adapted or intended to mark specific tissue sites, but rather to mark an entire region or structure of the body in order to evaluate anatomical niovements (i.e. swallowing nlotions). It also was not intended for use in humans.
Accordingly, what is needed is a method and device for non-surgically implanting potentially permanent nlarkers at the site of a lesion or other abnormal tissue, for the purpose of defining the margins of a lesion before it is removed and/or to establish its location after it has been removed. The markers should be easy to deploy and easily detected using state of the art imaging techniques.
A niethod of iinplanting markers directly into a patient's body using minimally invasive surgical tecliniques is described in Inteniational Patent No. WO
9608208A1 to Foerster et al. In this method, a clipping device is introduced to the lesion site by a tubular cannula. Once the clip is at the lesion site, an actuating means at the proximal end outside the patient deploys the clip into the tissue. This marking means can be used long term and can be imaged by niost imaging techniques. However, because of its small size, current ultrasound imaging systems are unable to detect it within the tissue.
Another method of implanting a marker is described in commonly assigned U.S.
Patent No. 5,402,310, filed February 21, 1997, and entitled "Apparatus and Method for Marking Tissue". The marker described in this method utilizes a central tang that is tensily loaded to cause a squarely supported, end contact bridge on the marker to bend resulting in the goal post arms to swing inward in an arcuate fashion to inch tissue. The tensile load on the tang is increased until it breaks at a predetermined location leaving the marker attached to the tissue site. Unfortunately, this method requires the marker to be pulled away from tissue when the marker is formed, consequently, limiting marker penetration and the amount of tissue grasped.
A surgical clip for permanently joining opposed tissue for an anastomosis procedure is described in U. S. Patent No. 4,733,664 to Kirsh et al. This is 15 accomplished using an applier, also disclosed, to pull on a frangible central tang to close a pair of spaced arcuate arms extending generally parallel in one direction from opposite ends of the plastically deformable bridge. The arms are brought around opposed tissue. A predetermined force is applied to create a tensile break of the neck in the tang. Specific angles of clip shoulder and applier are given.
The 20 applier jaw faces are in the range of 120 to 1800 with respect to one another, specifically 150 Unfortunately, the method of forming this clip suffers a fate similar to the method described in the preceding paragraph.
Accordingly, what is needed is a surgical marker for implantation at the sites 25 of a lesion or other abnormal tissue, for the purpose of defining the margins of a lesion before it is removed or to establish its location after it has been removed. The marker should be easy to deploy and easily detected using state of the art imaging techniques. Additionally, the marker must be capable of being formed without the marker being pulled away from the tissue, to ensure that an adequate amount of tissue will be grasped.
SUMMARY OF THE INVENTION
The invention is an implantable marker for implantation in tissue of a surgical patient The marker comprises a base, and first and second legs.
The base of the marker includes an elevated bridge. The bridge is bounded by first and second transitions.
The first leg descends from the first transition of the base. The first leg includes the following: a) a first distal tip remote from the first transition, b) a generally straight first leg arm adjacent the first distal tip, and c) a first camming marker surface between the first transition of the base and the first straight leg arm. The first camming marker surface extends outwardly from the first straight leg arm.
The second leg of the marker descends from the second transition of the base. The second leg includes the following: a) a second distal tip remote from the first transition, b) a generally straight second leg arm adjacent the second distal tip, and c) a second camming marker surface between the second transition of the base and the second straight leg arm.
The second camming marker surface extends outwardly from the straight second leg arm.
The implantable marker may further comprise a first reverse cleat protruding from said first camming marker surface and said first transition, and a second reverse cleat protruding from said second camming marker surface and said second transition; wherein said first and second straight leg arms are generally parallel to each other when said marker is in an open configuration, and said first and second straight leg arms gradually converge towards each other from a spaced-apart position adjacent said first and second transitions when said marker is in a closed configuration so as to form a marker apex at said first and second distal tips of said legs.
The first and second straight leg arms are generally parallel to each other when the marker is in an open configuration. The first and second straight leg arms gradually converge towards each other from a spaced-apart 8a position adjacent the first and second transitions when the marker is in a closed configuration. In the closed configuration, a marker apex is formed at the first and second distal tips of the legs.
Patent No. 5,402,310, filed February 21, 1997, and entitled "Apparatus and Method for Marking Tissue". The marker described in this method utilizes a central tang that is tensily loaded to cause a squarely supported, end contact bridge on the marker to bend resulting in the goal post arms to swing inward in an arcuate fashion to inch tissue. The tensile load on the tang is increased until it breaks at a predetermined location leaving the marker attached to the tissue site. Unfortunately, this method requires the marker to be pulled away from tissue when the marker is formed, consequently, limiting marker penetration and the amount of tissue grasped.
A surgical clip for permanently joining opposed tissue for an anastomosis procedure is described in U. S. Patent No. 4,733,664 to Kirsh et al. This is 15 accomplished using an applier, also disclosed, to pull on a frangible central tang to close a pair of spaced arcuate arms extending generally parallel in one direction from opposite ends of the plastically deformable bridge. The arms are brought around opposed tissue. A predetermined force is applied to create a tensile break of the neck in the tang. Specific angles of clip shoulder and applier are given.
The 20 applier jaw faces are in the range of 120 to 1800 with respect to one another, specifically 150 Unfortunately, the method of forming this clip suffers a fate similar to the method described in the preceding paragraph.
Accordingly, what is needed is a surgical marker for implantation at the sites 25 of a lesion or other abnormal tissue, for the purpose of defining the margins of a lesion before it is removed or to establish its location after it has been removed. The marker should be easy to deploy and easily detected using state of the art imaging techniques. Additionally, the marker must be capable of being formed without the marker being pulled away from the tissue, to ensure that an adequate amount of tissue will be grasped.
SUMMARY OF THE INVENTION
The invention is an implantable marker for implantation in tissue of a surgical patient The marker comprises a base, and first and second legs.
The base of the marker includes an elevated bridge. The bridge is bounded by first and second transitions.
The first leg descends from the first transition of the base. The first leg includes the following: a) a first distal tip remote from the first transition, b) a generally straight first leg arm adjacent the first distal tip, and c) a first camming marker surface between the first transition of the base and the first straight leg arm. The first camming marker surface extends outwardly from the first straight leg arm.
The second leg of the marker descends from the second transition of the base. The second leg includes the following: a) a second distal tip remote from the first transition, b) a generally straight second leg arm adjacent the second distal tip, and c) a second camming marker surface between the second transition of the base and the second straight leg arm.
The second camming marker surface extends outwardly from the straight second leg arm.
The implantable marker may further comprise a first reverse cleat protruding from said first camming marker surface and said first transition, and a second reverse cleat protruding from said second camming marker surface and said second transition; wherein said first and second straight leg arms are generally parallel to each other when said marker is in an open configuration, and said first and second straight leg arms gradually converge towards each other from a spaced-apart position adjacent said first and second transitions when said marker is in a closed configuration so as to form a marker apex at said first and second distal tips of said legs.
The first and second straight leg arms are generally parallel to each other when the marker is in an open configuration. The first and second straight leg arms gradually converge towards each other from a spaced-apart 8a position adjacent the first and second transitions when the marker is in a closed configuration. In the closed configuration, a marker apex is formed at the first and second distal tips of the legs.
The niarker of this invention is especially adapted for iniplantation at the site of a legion or other abnonnal tissue particularly during a biopsy procedure to define the nlargins of a legion before it is biopsied or to establish its location at some later tinle after the biopsy sample has been removed. The configuration of the marker, particularly the combination of features of the marker with the first and second camming niarker surfaces of the legs of ttie marker, facilitate the deployment of the niarker in a manner in which the nlarker can be pushed into the tissue during deploynient for deep tissue penetration. Significantly, in contrast to the prior art io markers, the deeper penetration of the marker of this invention as it is deployed into tissue enables the inarker to grasp a greater amount of tissue, therefore minimizing the potential of the marker to unintentionally dislodge.
Although the marker of this invention is particularly suited for endoscopic biopsy applications to mark the site of biopsied tissue, it can be used for other endoscopic applications and applications involving conventional open surgical procedures. For example, the marker niay find utility in surgical procedures reyuiring the fastening of tissue or the ligation of vessels, such as those surgical procedures which involve clipping, stapling, anastomosis, hernia tacking, buttressing, niicro-vascular applications, or any opposed edge joining applications.
Brief Description of the Drawines Figure 1 is an isonietric view of the implantable marker constructed in accordance with a preferred enlbodiment of this invention.
Figure 2 is a front elevational view of the marker of Figure 1.
Figure 3 is a side elevational view of the niarker of Figure 1.
Although the marker of this invention is particularly suited for endoscopic biopsy applications to mark the site of biopsied tissue, it can be used for other endoscopic applications and applications involving conventional open surgical procedures. For example, the marker niay find utility in surgical procedures reyuiring the fastening of tissue or the ligation of vessels, such as those surgical procedures which involve clipping, stapling, anastomosis, hernia tacking, buttressing, niicro-vascular applications, or any opposed edge joining applications.
Brief Description of the Drawines Figure 1 is an isonietric view of the implantable marker constructed in accordance with a preferred enlbodiment of this invention.
Figure 2 is a front elevational view of the marker of Figure 1.
Figure 3 is a side elevational view of the niarker of Figure 1.
Figure 4 is a fragmentary distal end sectional view illustrating the plan view of the marker of Figure 1 in its loaded position within the shaft of an applier.
Figures 5-9 are fragnientary distal end sectional views illustrating sequentially the fonnation of the loaded niarker depicted in Figure 4.
Detailed Description of the Preferred Enlbodirnent lo Referring initially to Figures 1-3, the preferred marker 10 of this invention is illustrated. The niarker has a base 11 and first and second legs, 12 and 13, respectively. The base has an elevated bridge 14. The elevated bridge has an arcuate bottom surface 15. It also lias a generally flat top 16.
The marker has a first transition 17 on one side of the elevated bridge and a second transition 18 on the other side of the elevated bridge. The first and second transitions separate the elevated bridge of the base froni the descending first and second legs of the marker. The first leg has a first, beveled pointed tip 19 at the distal end of the leg remote from the first transition 17. Similarly, the second leg has a second, beveled pointed tip 20 at its distal end. Adjacent the first and second pointed tips of the legs, there are first and second straight leg arms, 21 and 22, respectively. Interposed between the first and second transitions and the first and second straiglit leg arms, are first and second camming marker surfaces 23 and 24, respectively. The camming marker surfaces extend outwardly from the straight leg arms of the legs. The first and second camming niarker surfaces have first and second interior surfaces, 25 and 26, respectively, which are arcuate in configuration.
Figures 5-9 are fragnientary distal end sectional views illustrating sequentially the fonnation of the loaded niarker depicted in Figure 4.
Detailed Description of the Preferred Enlbodirnent lo Referring initially to Figures 1-3, the preferred marker 10 of this invention is illustrated. The niarker has a base 11 and first and second legs, 12 and 13, respectively. The base has an elevated bridge 14. The elevated bridge has an arcuate bottom surface 15. It also lias a generally flat top 16.
The marker has a first transition 17 on one side of the elevated bridge and a second transition 18 on the other side of the elevated bridge. The first and second transitions separate the elevated bridge of the base froni the descending first and second legs of the marker. The first leg has a first, beveled pointed tip 19 at the distal end of the leg remote from the first transition 17. Similarly, the second leg has a second, beveled pointed tip 20 at its distal end. Adjacent the first and second pointed tips of the legs, there are first and second straight leg arms, 21 and 22, respectively. Interposed between the first and second transitions and the first and second straiglit leg arms, are first and second camming marker surfaces 23 and 24, respectively. The camming marker surfaces extend outwardly from the straight leg arms of the legs. The first and second camming niarker surfaces have first and second interior surfaces, 25 and 26, respectively, which are arcuate in configuration.
The niarker has first and second reverse cleats, 27 and 28, respectively. The cleats are triangular in configuration. The first cleat protrudes froni the first caninling niarker surface and the first transition. Siniilarly, the second cleat protrudes from the second camniing marker surface and the second transition.
The cleats protrude generally parallel to the first and second straight leg arms of the legs.
The bridge of the tnarker has a pair of top arcuate surfaces, 29 and 30, respectively, separated by the flat top of the bridge on the base of the marker. The first top arcuate surface 29 is bounded by the ititerior surface of the first spike and io the surface adjacent the flat top of the elevated bridge. In a similar fashion, the second top arcuate surface 30 is bounded by the interior surface of the second spike and the surface adjacetit the flat top.
The preferred marker is symmetrical about a centerline axis taken througli is the center of the elevated bridge 14 of the base of the marker, and drawn parallel to the first and second straight leg arms, 21 and 22, of the legs. The centerline axis is designated as "L" in Figure 2. In addition, the region of the marker between the flat top of the elevated bridge and the arcuate bottom surface of the bridge can be characterized as a bridge flexure region of reduced thickness. The flexure region of 20 the elevated bridge increases the flexibility of the marker when it is deployed from its open position to its closed position, and minimizes the tendency for the straight leg anns of the legs of the marker to spring back towards their open configuration after formation. This increased flexibility, coupled with the arcuate synimetrical nature of the elevated bridge, provides a uniform load on the base of the marker 25 during marker formation. In its open configuration, the first and second straight leg arms of the legs of the marker are generally parallel to each other.
The first and second reverse cleats of the marker are provided to prevent undesired migration of the fonned marker when it is in its closed position in tissue by preventing tissue from sliding off of the bridge. Consequently, the surface of the bridge firmly bears against tissue to prevent undesired migration of the marker.
Referring now to Figures 4-9, there is illustrated the deploynient of the preferred marker of this invention froni its open configuration to its closed configuration. A markei- applier 31 is provided which has a tubular shaft 32..
The marker 10 is positioned inside the tubular shaft. The tubular shaft is sized so that the camniing marker surfaces 23 and 24 of the legs of the marker contact the shaft inner wall 33 of the tubular shaft. The distal end of the tubular shaft has a distal caniming io wall surface 34 extending radially inwardly from the shaft inner-wall. The distal camming wall surface is sized so that this surface contacts the first and second straight leg arms of the legs of the marker when the marker is in its open configuration, and the leg arms are parallel to each other as illustrated in Figure 4.
An applier push rod 35 is positioned on the flat top of the elevated bridge on the is base of the marker, and the pointed distal tips of the legs protrude from the tubular shaft of the applier.
When the applier push rod 35 is pushed distally to deploy the marker from its open position where the straight leg arms are parallel to each other to its closed 20 position, the niarker is urged out of the tubular shaft of the applier. As the marker moves distally within the tubular shaft of the applier, the camming marker surfaces of the legs of the niarker are camnied against the distal camming wall surface of the applier. This camming action urges the straight leg arms of the legs of the marker to converge towards each other as the elevated bridge of the base of the marker bends 25 inwardly at the bridge flexure region. When the marker is fully formed in its closed position as depicted in Figure 9, the distal tips of the legs come together to form a niarker apex 36. The straight leg arms reniain in a spaced-apart position adjacent the first second transitions of the niarker, and the niarker has formed a generally dianiond-shaped configuration which is illustrated in Figure 9.
The cleats protrude generally parallel to the first and second straight leg arms of the legs.
The bridge of the tnarker has a pair of top arcuate surfaces, 29 and 30, respectively, separated by the flat top of the bridge on the base of the marker. The first top arcuate surface 29 is bounded by the ititerior surface of the first spike and io the surface adjacent the flat top of the elevated bridge. In a similar fashion, the second top arcuate surface 30 is bounded by the interior surface of the second spike and the surface adjacetit the flat top.
The preferred marker is symmetrical about a centerline axis taken througli is the center of the elevated bridge 14 of the base of the marker, and drawn parallel to the first and second straight leg arms, 21 and 22, of the legs. The centerline axis is designated as "L" in Figure 2. In addition, the region of the marker between the flat top of the elevated bridge and the arcuate bottom surface of the bridge can be characterized as a bridge flexure region of reduced thickness. The flexure region of 20 the elevated bridge increases the flexibility of the marker when it is deployed from its open position to its closed position, and minimizes the tendency for the straight leg anns of the legs of the marker to spring back towards their open configuration after formation. This increased flexibility, coupled with the arcuate synimetrical nature of the elevated bridge, provides a uniform load on the base of the marker 25 during marker formation. In its open configuration, the first and second straight leg arms of the legs of the marker are generally parallel to each other.
The first and second reverse cleats of the marker are provided to prevent undesired migration of the fonned marker when it is in its closed position in tissue by preventing tissue from sliding off of the bridge. Consequently, the surface of the bridge firmly bears against tissue to prevent undesired migration of the marker.
Referring now to Figures 4-9, there is illustrated the deploynient of the preferred marker of this invention froni its open configuration to its closed configuration. A markei- applier 31 is provided which has a tubular shaft 32..
The marker 10 is positioned inside the tubular shaft. The tubular shaft is sized so that the camniing marker surfaces 23 and 24 of the legs of the marker contact the shaft inner wall 33 of the tubular shaft. The distal end of the tubular shaft has a distal caniming io wall surface 34 extending radially inwardly from the shaft inner-wall. The distal camming wall surface is sized so that this surface contacts the first and second straight leg arms of the legs of the marker when the marker is in its open configuration, and the leg arms are parallel to each other as illustrated in Figure 4.
An applier push rod 35 is positioned on the flat top of the elevated bridge on the is base of the marker, and the pointed distal tips of the legs protrude from the tubular shaft of the applier.
When the applier push rod 35 is pushed distally to deploy the marker from its open position where the straight leg arms are parallel to each other to its closed 20 position, the niarker is urged out of the tubular shaft of the applier. As the marker moves distally within the tubular shaft of the applier, the camming marker surfaces of the legs of the niarker are camnied against the distal camming wall surface of the applier. This camming action urges the straight leg arms of the legs of the marker to converge towards each other as the elevated bridge of the base of the marker bends 25 inwardly at the bridge flexure region. When the marker is fully formed in its closed position as depicted in Figure 9, the distal tips of the legs come together to form a niarker apex 36. The straight leg arms reniain in a spaced-apart position adjacent the first second transitions of the niarker, and the niarker has formed a generally dianiond-shaped configuration which is illustrated in Figure 9.
The preferred applier for delivering and deploying the marker of this invention is described in detail in commonly assigned, U.S. Patent No. 6,261,302, filed June 26, 1998.
The marker of this invention can be made of any implantable material which is biocompatible and can exliibit the requisite closure force to prevent inadvertent dislodgment of the marker when it is anchored in tissue. The preferred marker of this invention is composed of 316 LVM stainless steel (316 L stainless steel io fabricated in a vacuum melt furnace for higher purity). Alternatively, the marker may be composed of absorbable polymers, as well as non-magnetic materials particularly suited for MRI imaging applications.
The marker caii be advantageously mass produced using a conventional photoetching process to create a plurality of markers affixed to the desired carriers, typically a sheet of metal composed of 316 LVM stainless steel. The metal sheet can be cut into carrier rows, and sequentially fed into a cutting die for shearing the individual markers from the carrier rows.
The marker of this invention can be coated with agents to lower friction, stop bleeding or accomplish any other desired effect. Additionally the legs of the marker can be modified to include the addition of barb-like features that could increase the holding strength, migration resistance and imaging ability of the marker.
Although this invention has been described in connection with its most preferred embodiment, additional embodiments are within the scope and spirit of the claimed invention. The preferred marker of this invention is intended merely to illustrate the invention, and not limit the scope of the invention as it is defined in the claims which follow.
The marker of this invention can be made of any implantable material which is biocompatible and can exliibit the requisite closure force to prevent inadvertent dislodgment of the marker when it is anchored in tissue. The preferred marker of this invention is composed of 316 LVM stainless steel (316 L stainless steel io fabricated in a vacuum melt furnace for higher purity). Alternatively, the marker may be composed of absorbable polymers, as well as non-magnetic materials particularly suited for MRI imaging applications.
The marker caii be advantageously mass produced using a conventional photoetching process to create a plurality of markers affixed to the desired carriers, typically a sheet of metal composed of 316 LVM stainless steel. The metal sheet can be cut into carrier rows, and sequentially fed into a cutting die for shearing the individual markers from the carrier rows.
The marker of this invention can be coated with agents to lower friction, stop bleeding or accomplish any other desired effect. Additionally the legs of the marker can be modified to include the addition of barb-like features that could increase the holding strength, migration resistance and imaging ability of the marker.
Although this invention has been described in connection with its most preferred embodiment, additional embodiments are within the scope and spirit of the claimed invention. The preferred marker of this invention is intended merely to illustrate the invention, and not limit the scope of the invention as it is defined in the claims which follow.
Claims (8)
1. An implantable marker for implantation in tissue of a surgical patient, said marker comprising:
a) a base, said base including an elevated bridge having a top and a pair of top arcuate surfaces separated by said top, said bridge bounded by first and second transitions;
b) a first leg descending from said first transition of said base, said first leg including:
i) a first distal tip remote from said first transition;
ii) a generally straight first leg arm adjacent said first distal tip; and iii) a first camming marker surface between said first transition of said base and said first straight leg arm, said first camming marker surface extending outwardly from said first straight leg arm;
c) a second leg descending from said second transition of said base, said second leg including:
i) a second distal tip remote from said second transition;
ii) a generally straight second leg arm adjacent said second distal tip; and iii) a second camming marker surface between said second transition of said second base and said second straight leg arm, said second camming marker surface extending outwardly from said second straight leg arm; and d) a first reverse cleat protruding from said first camming marker surface and said first transition, and a second reverse cleat protruding from said second camming marker surface and said second transition;
wherein said first and second straight leg arms are generally parallel to each other when said marker is in an open configuration, and said first and second straight leg arms gradually converge towards each other from a spaced-apart position adjacent said first and second transitions when said marker is in a closed configuration so as to form a marker apex at said first and second distal tips of said legs.
a) a base, said base including an elevated bridge having a top and a pair of top arcuate surfaces separated by said top, said bridge bounded by first and second transitions;
b) a first leg descending from said first transition of said base, said first leg including:
i) a first distal tip remote from said first transition;
ii) a generally straight first leg arm adjacent said first distal tip; and iii) a first camming marker surface between said first transition of said base and said first straight leg arm, said first camming marker surface extending outwardly from said first straight leg arm;
c) a second leg descending from said second transition of said base, said second leg including:
i) a second distal tip remote from said second transition;
ii) a generally straight second leg arm adjacent said second distal tip; and iii) a second camming marker surface between said second transition of said second base and said second straight leg arm, said second camming marker surface extending outwardly from said second straight leg arm; and d) a first reverse cleat protruding from said first camming marker surface and said first transition, and a second reverse cleat protruding from said second camming marker surface and said second transition;
wherein said first and second straight leg arms are generally parallel to each other when said marker is in an open configuration, and said first and second straight leg arms gradually converge towards each other from a spaced-apart position adjacent said first and second transitions when said marker is in a closed configuration so as to form a marker apex at said first and second distal tips of said legs.
2. The implantable marker of claim 1 wherein said marker is symmetrical about a centerline axis drawn parallel to said first and second straight leg arms and taken through the center of said elevated bridge of said base of said marker.
3. The implantable marker of claim 2 wherein said marker has a diamond-shaped configuration in the closed position.
4. The implantable marker of claim 3 wherein said first and second distal tips of said legs are beveled pointed tips.
5. The implantable marker of claim 4 wherein said elevated bridge has an arcuate bottom surface.
6. The implantable marker of claim 5 wherein said top of said elevated bridge is a generally flat top, and said bridge includes a bridge flexure region of reduced thickness between said flat top and said arcuate bottom surface of said elevated bridge.
7. The implantable marker of claim 6 wherein said first and second reverse cleats are generally triangular in configuration.
8. The implantable marker of claim 7 wherein said first and second reverse cleats protrude generally parallel to said first and second straight leg arms of said legs.
Applications Claiming Priority (2)
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US09/105,757 US5941890A (en) | 1998-06-26 | 1998-06-26 | Implantable surgical marker |
US09/105,757 | 1998-06-26 |
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CA2276789A1 CA2276789A1 (en) | 1999-12-26 |
CA2276789C true CA2276789C (en) | 2007-12-18 |
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CA002276789A Expired - Fee Related CA2276789C (en) | 1998-06-26 | 1999-06-23 | Implantable surgical marker |
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EP (1) | EP0966924B1 (en) |
JP (1) | JP4070907B2 (en) |
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-
1998
- 1998-06-26 US US09/105,757 patent/US5941890A/en not_active Expired - Lifetime
-
1999
- 1999-05-26 AU AU32261/99A patent/AU745589B2/en not_active Ceased
- 1999-06-23 CA CA002276789A patent/CA2276789C/en not_active Expired - Fee Related
- 1999-06-25 JP JP18039399A patent/JP4070907B2/en not_active Expired - Fee Related
- 1999-06-25 EP EP99305015A patent/EP0966924B1/en not_active Expired - Lifetime
- 1999-06-25 DE DE69910684T patent/DE69910684T2/en not_active Expired - Lifetime
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JP4070907B2 (en) | 2008-04-02 |
DE69910684T2 (en) | 2004-07-08 |
EP0966924B1 (en) | 2003-08-27 |
US5941890A (en) | 1999-08-24 |
JP2000102546A (en) | 2000-04-11 |
AU745589B2 (en) | 2002-03-21 |
DE69910684D1 (en) | 2003-10-02 |
CA2276789A1 (en) | 1999-12-26 |
AU3226199A (en) | 2000-01-13 |
EP0966924A1 (en) | 1999-12-29 |
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