CA2275231A1 - Intravascular catheter probe for clinical oxygen, ph and co2 measurement - Google Patents

Intravascular catheter probe for clinical oxygen, ph and co2 measurement Download PDF

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Publication number
CA2275231A1
CA2275231A1 CA002275231A CA2275231A CA2275231A1 CA 2275231 A1 CA2275231 A1 CA 2275231A1 CA 002275231 A CA002275231 A CA 002275231A CA 2275231 A CA2275231 A CA 2275231A CA 2275231 A1 CA2275231 A1 CA 2275231A1
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CA
Canada
Prior art keywords
oxygen
detection device
fiber optic
oxygen sensor
measurement
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002275231A
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French (fr)
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CA2275231C (en
Inventor
David F. Wilson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxygen Enterprises Ltd
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Individual
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Filing date
Publication date
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Publication of CA2275231A1 publication Critical patent/CA2275231A1/en
Application granted granted Critical
Publication of CA2275231C publication Critical patent/CA2275231C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14539—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring pH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14542—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring blood gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter

Abstract

Methods and apparatus for the measurement of oxygen, pH and CO2 in human and animal tissue is provided in which the compounds preferably comprise a chromophore and/or fluorphor capable of absorbing an amount of energy and subsequently releasing the energy w phosphorescent and/or fluorescent light, and wherein the phosphorescence is quenched by molecular oxygen according to the Stern-Volmet relationship. CO2 is measured by a fluorphor wliich alters fluorescence with pH. The apparatus includes an optical fiber (2) for transmitting light to a probe (70) that includes a gas permeable film (10) enclosing a portion (12) of the distal end of the optical fiber to form a reservoit (14) of a solution of the oxygen quenchable phosphorescent compound and/or the fluorescence emitting compound. The apparatus alsc includes a light source (36) and a light detector (34).

Claims (22)

1. A detection devices for tissue oxygen and/or pH
(CO2) measurement in animals and humans comprising a fiber optic means effective for transmitting emitted phosphorescent and/or fluorescent light, a probes means at one end of the fiber optic means comprising a portion of the fiber optic means enclosed by a gas-permeable film, and with a reservoir of a liquid oxygen quenchable phosphorescence emitting oxygen sensor and/or fluorescence emitting pH sensor situated between the gas-permeable membranae and optic fiber means, and further comprising at the other end of tree fiber optic means a phosphorescent and/or fluorescent. detection means and an excitation light emitting means.
2. The device of claim 1 wherein said sensor is an oxygen-quenchable phosphorescence emitting oxygen sensor.
3. The device of claim 2 wherein said oxygen sensor comprises an absorption band at a wavelength of greater than about 400 nm.
4. The device of claim 1 wherein said sensor comprises an emission band at a wavelength of greater than about 400 nm.
5. The device of claim 1 wherein said absorption and emission bands are located in the range from about 400 nm to about 1000 nm.
6. The detection device of claim 1 wherein said absorption band ranges from about 400 to about 700 nm.
7. The device of claim 2 wherein said sensor comprises porphyrin.
8. The detection device of claim 7 wherein said porphyrin comprises metalloporphyrin.
9. The detection device of Claim 8 comprising an oxygen sensor compound which is capable of phosphorescing and which has the formula:
wherein:
R1 is substituted or unsubstituted aryl;
R2 and R3 are independently hydrogen or are linked together to form substituted or unsubstituted aryl; and M is H2 or a metal.
10. The detection device of claim 9 wherein the oxygen sensor compound M is a metal selected from the group consisting of Zn, A1, Sn, Y, La, Lu, Pd, Pt and derivatives thereof.
11. The oxygen sensor compound of claim 10 wherein said derivatives comprise LuOH, YOH, LaOH or AlOH.
12. The detection device of claim 9 wherein R2 and R3 of the oxygen sensor compound are linked together to form an aryl system.
13. The oxygen sensor compound of claim 12 wherein said aryl system comprises phenyl, naphthyl or anthryl.
14. The oxygen sensor compound of claim 13 wherein R1 comprises substituted phenyl.
15. The oxygen sensor compound of claim 14 which is Pd-meso-tetra-(4-carboxy-phenyl) porphine.
16. The detection device of any of claims 1-15 in which said portion of said fiber optic means enclosed by said gas permeable film contains one or more grooves.
17. The detection device of any of claims 1-15 in which the refractive index of said reservoir liquid is near that of said fiber optic means.
18. The detection device of claim 16 in which the refractive index of said reservoir liquid is substantially identical to that of the fiber opvic means.
19. The detection device of any of claims 1-15 wherein said portion of said fiber optic means enclosed by said gas permeable film contains at least two or more grooves, and wherein at least a portion of the grooves contain oxygen quenchable phosphorescence emitting oxygen sensor and a portion contains a fluorescence emitting pH sensor.
20. The detection device of claim 19 wherein the refractive index of said reservoirs is near that of said fiber optic means.
21. The detection device of claim 20 wherein the refractive index of said reservoirs is substantially identical to that of the fiber optic means.
22. A method for tissue oxygen measurement and/or pH measurement in animals and humans comprising measurement thereof with the device of claim 1.
CA2275231A 1996-12-16 1997-12-12 Intravascular catheter probe for clinical oxygen, ph and co2 measurement Expired - Fee Related CA2275231C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/767,305 US5830138A (en) 1996-12-16 1996-12-16 Intravascular catheter probe for clinical oxygen, pH and CO2 measurement
US08/767,305 1996-12-16
PCT/US1997/023605 WO1998026709A1 (en) 1996-12-16 1997-12-12 INTRAVASCULAR CATHETER PROBE FOR CLINICAL OXYGEN, pH AND CO2 MEASUREMENT

Publications (2)

Publication Number Publication Date
CA2275231A1 true CA2275231A1 (en) 1998-06-25
CA2275231C CA2275231C (en) 2010-11-09

Family

ID=25079084

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2275231A Expired - Fee Related CA2275231C (en) 1996-12-16 1997-12-12 Intravascular catheter probe for clinical oxygen, ph and co2 measurement

Country Status (8)

Country Link
US (1) US5830138A (en)
EP (1) EP0971623B1 (en)
JP (1) JP2001509888A (en)
AT (1) ATE332101T1 (en)
AU (1) AU719524B2 (en)
CA (1) CA2275231C (en)
DE (1) DE69736300T2 (en)
WO (1) WO1998026709A1 (en)

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Also Published As

Publication number Publication date
ATE332101T1 (en) 2006-07-15
EP0971623A4 (en) 2001-08-29
AU5614698A (en) 1998-07-15
DE69736300D1 (en) 2006-08-17
EP0971623A1 (en) 2000-01-19
WO1998026709A1 (en) 1998-06-25
DE69736300T2 (en) 2007-07-05
US5830138A (en) 1998-11-03
AU719524B2 (en) 2000-05-11
CA2275231C (en) 2010-11-09
JP2001509888A (en) 2001-07-24
EP0971623B1 (en) 2006-07-05

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