CA2235365C - Apparatus and method for delivering electrical stimulus to tissue - Google Patents

Apparatus and method for delivering electrical stimulus to tissue Download PDF

Info

Publication number
CA2235365C
CA2235365C CA002235365A CA2235365A CA2235365C CA 2235365 C CA2235365 C CA 2235365C CA 002235365 A CA002235365 A CA 002235365A CA 2235365 A CA2235365 A CA 2235365A CA 2235365 C CA2235365 C CA 2235365C
Authority
CA
Canada
Prior art keywords
housing
electrodes
electrical
battery
closure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002235365A
Other languages
French (fr)
Other versions
CA2235365A1 (en
Inventor
Peter H. Lathrop
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nexmed Holdings Inc
Original Assignee
Nexmed Holdings Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nexmed Holdings Inc filed Critical Nexmed Holdings Inc
Publication of CA2235365A1 publication Critical patent/CA2235365A1/en
Application granted granted Critical
Publication of CA2235365C publication Critical patent/CA2235365C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014External stimulators, e.g. with patch electrodes
    • A61N1/36021External stimulators, e.g. with patch electrodes for treatment of pain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/326Applying electric currents by contact electrodes alternating or intermittent currents for promoting growth of cells, e.g. bone cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372Arrangements in connection with the implantation of stimulators
    • A61N1/375Constructional arrangements, e.g. casings
    • A61N1/3756Casings with electrodes thereon, e.g. leadless stimulators

Abstract

This invention is an electrical stimulation apparatus (10) and method for applying an electrical stimulation to a lesion.
The apparatus includes a housing (12) having a battery and an electrical circuit mounted inside the housing (12). A pair of electrodes (16, 17) are removably mounted to the housing (12) and extend therefrom so as to accommodate being touched to the skin on opposite sides of the lesion. A switch (20) on the housing allows the user to selectively supply electrical energy to the electrodes (16, 17). A first light (40) on the housing is illuminated when the switch (20) is depressed thereby providing a visual indication that electrical energy is being supplied to the electrodes. A second light (41) on the housing provides a visual indication of a low battery condition. A closure (14) is mountable to the housing and encloses the electrodes, switch, and light within the closure. The size and shape of the apparatus are designed for portability.

Description

APPARATUS AND METHOD FOR DELIVERING
ELECTRICAL STIMULUS TO TISSUE
1 Background Field of the Invention This invention relates to the electrical 9. stimulation of living tissue and, more particularly, to a convenient, portable electrical stimulation apparatus E. and method for selectively delivering electrical T stimulation to living tissue.

9 The Prior Art 10~ The beneficial results from electrical stimulation 11 of living tissue are well known in the art and range 12 from devices for the combined nerve fiber and body 13 stimulation such as shown in U.S. Patent No. 5,117,826 14 to the method for. treating herpes simplex as shown in U.S. Patent No. 5,133,352. Other devices within this 16 general category include the small size, low frequency 17 curing apparatus shown in U.S. Patent 4,922,906; the 18 electrotherapeutic treatment apparatus shown in U.S.

19 Patent No. 5,107,835; the method for the treatment of :herpes simplex and herpes zoster shown in U.S. Patent 21 :No. 4,913,148: and the low frequency electrotherapeutic 22 device shown in U.S. Patent No. 5,133,351, to name a 23 few.

. 24 An examination of each of these known references :reveals a rather complex device which involves extensive 1 preparation for use or is otherwise too cumbersome to be 2 readily portable. However, I have found that the 3 development of a herpes-caused lesion is preceded by an 4 associated nerve sensation that signals to the patient that such a lesion is in the developmental stage. I

6 have also found that timing is critical in the 7 application of the electrical stimulus to the lesion 8 site. Specifically, it is important that the patient 9 have the ability to promptly apply electrical stimulation to the potential lesion site especially 11 before the lesion appears with the site selection being 12 based solely upon the pre-lesion nerve sensation. This, 13 in turn, requires that the electrical stimulation 14 apparatus should be readily accessible in a convenient, hand-portable configuration to thereby provide the user 16 with the capability to promptly and even discretely 17 apply electrical stimulation to any predetermined site 18 on the body. Such an apparatus and method is disclosed 19 and claimed herein.

21 Brief Summarv and Objects of the Invention 22 This invention involves a novel electrical 23 stimulation apparatus and method for delivering 24 electrical stimulation to a preselected area of the skin. The apparatus is a small, hand-held housing 26 containing a battery, an electrical circuit, a switch, 27 and a pair of electrodes removably mounted to the 28 device. A two color light system provides a visual 1 indication to show that the device is operational or if 2 there is a low-battery condition. A closure 3 telescopically engages the housing to encase both the 4 electrodes and the switch and to present a smooth profile to the apparatus. The apparatus is small enough 6 that it conveniently fits within the hand of the user 7 and is mountable on a key chain. The small size, 8 convenience of use, and pleasing visual appearance all 9 lend themselves to rendering the apparatus easy to carry 7.0 and simple use to further encourage its frequent use by 7.1 persons who would benefit from the application of 7.2 electrical stimulus with my novel apparatus and method.

7.3 The electrodes are releasably mounted to the device for 7.4 ease of replacement.

7.5 It is, therefore, a primary object of this J.6 invention to provide improvements in apparatus for 1.7 delivering electrical stimulation to living tissue.

1.8 Another object of this invention is to provide 1.9 improvements in the method of delivering electrical 20 stimulation to living tissue.

21 Another object of this invention is to provide a 22 small, hand-portable electrical stimulation apparatus.

23 Another object of this invention is to provide a 24 smooth-contoured, relatively small electrical 25 stimulation apparatus.

~26 Another object of this invention is to provide an .27 electrical stimulation apparatus having a pair of 28 removable electrodes.

1 Another object of this invention is to provide an 2 electrical stimulation apparatus having a closure for 3 enclosing the electrodes and the switch.

4 Another object of this invention is to provide a light system for visually indicating that the device is 6 operational.

7 Another object of this invention is to provide an 8 indicator system to indicate when there is a low battery 9 condition.

These and other objects arid features of the present 11 invention will become more readily apparent from the 12 following description and the appended claims.

14 Brief Description of the Drawincx Figure 1 is an exploded, perspective view of a 16 presently preferred embodiment of my novel electrical 17 stimulation apparatus and its closure;

18 Figure 2 is a perspective view of the electrical 19 stimulation apparatus of Figure 1 shown in the environment of a hand and an area of skin; and 21 Figure 3 is a schematic diagram of one embodiment 22 of the electrical circuitry of my novel electrical 23 stimulation apparatus.

Detailed Description of the Preferred Embodiment 26 The invention is best understood by reference to 27 the drawing wherein like parts are designated by like 1 numerals throughout in conjunction with the following 2 description.

4 neneral Discussion I have invented a novel, hand-portable electrical 6 stimulation apparatus and method for enabling the user 7 to selectively apply electrical stimulation to the skin 8 at preselected locations and at any predetermined time 9 or time interval. This novel feature is made possible la by reason of the relatively small size and convenience 11 with which my novel electrical stimulation apparatus can 12 be used. Further, I have specifically designed my novel 13 device with a smooth, aesthetically pleasing external 14 profile so as to render it more amenable to being carried continually by the user. To facilitate its 16 being carried at all times by the user I have also 17 .included an attachment site for making it possible to 18 releasably attach the electrical stimulation apparatus 19 i.o a key chain or the like.

My electrical stimulation apparatus is configured 21 as a housing and a closure that releasably fits on the 22 Sand of the housing. The housing contains the battery 23 and the electronic circuitry as well as an externally .24 accessible switch. A pair of electrodes are releasably :25 attached to the housing and are adapted to being touched 26 t:o the skin to provide the electrical contact with the 27 .>kin. The electrodes are releasably attached to the z8 housing in order to allow them to be readily sterilized 1 or replaced in the event replacement is required for 2 medical reasons. The housing is configured with a 3 relatively small external profile so as to allow it to 4 be easily held in and, possibly, even concealed within the confines of the user's hand. This feature 6 contributes to the overall effectiveness of my 7 electrical stimulation apparatus in that it allows the 8 user to discretely apply electrical stimulation where 9 one would otherwise be intimidated into not using this l0 novel invention. For example, if a user were attending 11 a concert and felt the early stages of a herpes lesion 12 on the lip, the user will be able to discretely palm my 13 electrical stimulator and touch the electrodes to the 14 affected area on the lip and the thereby effectively inhibit the formation of a lesion thereon.

16 The switch is mounted on the housing at a location 17 where it is concealed by the closure when the closure is 18 mounted to the housing. This configuration precludes 19 inadvertent activation of the switch when the electrical stimulation apparatus is not in use and is being carried 21 in a pocket, purse, or the like.

22 A light system is mounted on the housing at a 23 position generally between the electrodes and provides 24 the user with a visual indication when adequate electrical energy is being supplied to the electrodes 26 upon activation of the switch. This is an important 27 feature since the electrical energy supplied to the 28 electrodes by the electrical stimulation apparatus is of 1 such a low power as to be tactilely undetectable by the 2 user. The light thereby assures the user that 3 sufficient electrical energy is being delivered to the 4 electrodes. The second light visually indicates to the user that the battery is in a low-battery condition and 6 is failing to deliver sufficient electrical energy to 7 supply the electrical stimulation of this invention. In 8 this instance, one light may be red for a low battery 9 condition, while the other light may be green when the 1.U switch is closed to indicate that the device is 11 functioning properly.

13 Detailed Description 14 Referring now to Figures 1 and 2, the novel electrical stimulation apparatus of my invention is 16 shown generally at 10 and includes a housing 12, a 17 ' c:losure 14, and a pair of replaceable electrodes 16 and 18 1'7 removably mounted to housing 12. An activation 19 switch 20 is nested within a recess 18 on one side of housing 12 and is adapted to be concealed beneath 21 closure 14 when closure 14 is secured to housing 12.

22 Housing 12 includes an undercut section 22 around the 23 vicinity of switch 20 so as to accommodate closure 14 24 telescopically receiving electrodes 16 and 17 along with switch 20 to thereby enclose all of these elements ~26 w:ithin the confines of closure 14. Undercut section 22 27 and closure 14 are both dimensionally configured so that 28 closure 14 is snugly engageable to housing 12 in a snap-1 fit relationship. Exteriorly, closure 14 cooperates 2 with housing 12 to provide a continuous, smooth external 3 profile to all of electrical stimulator apparatus 10 as 4 represented by the external surfaces of housing 12 and closure 14. A retainer 42 is formed on the end of 6 housing 12 and includes a hole 44 therethrough for the 7 purpose of attaching electrical stimulator apparatus to 8 a key chain, identity tag, or the like.

9 Housing 12 is configured to releasably engage each of electrodes 16 and 17 in a snap-fit relationship.

11 Specifically, with reference to electrode 16, a cutaway 12 section is shown in housing 12 in order to reveal the 13 snap-fit relationship between housing 12 and electrode 14 16. Electrode 16 is configured with a pointed end 24 having a circumferential groove 26 around the base of 16 pointed end 24. A hole 28 is formed in housing 12 to 17 enable pointed end 24 to be inserted therethrough into 18 engagement with spring clip 30. Spring clip 30 is 19 formed from a pair of resilient, metal strips 32 and 33 each of which are mirror images of the other and 21 respectively include sloped surfaces 34 and 35 which 22 terminate in inwardly directed detents 36 and 37.

23 Sloped surfaces 34 and 35 receive pointed end 24 which 24 forces apart metal strips 32 and 33 until groove 26 is engaged by detents 36 and 37. The resiliency of metal 26 strips 32 and 33 provides spring clip 30 with the 27 necessary retention force to releasably hold electrode 28 16 in housing 12. Removal of electrode 16 is readily 1 accomplished by the user (not shown) firmly grasping 2 electrode 16 and sharply pulling electrode 16 outwardly 3 to cause detents 36 and 37 to disengage from groove 26.

4 Electrode 16 may then be sterilized or even discarded and replaced with another electrode 16.

6 Housing 12 includes lights 40 and 41 mounted to the 7 end thereof at a position between electrodes 16 and 17.

8 Light 40 provides a visual indicator to the user (not 9 shown) when switch 20 is activated and that adequate electrical energy is available for electrodes 16 and 17.

11 The presence of light 40 is particularly important in 12 that the electrical current supplied to electrodes 16 13 and 17 is of such a low magnitude as to be undetectable 14 'when electrical stimulator apparatus 10 is applied to tissue. On the other hand, light 41 provides a visual 16 indication to the user that a low battery condition 17 exists in electrical stimulator apparatus 10 such that 18 insufficient electrical energy is available to 19 electrodes 16 and 17. Either light 40 or light 41 will ;become illuminated upon closure of switch 20 thereby 21 readily informing the user as to the operational status 22 ~of electrical stimulator apparatus l0. In one prototype 23 of electrical stimulator apparatus 10 light 40 was 24 .configured as a green light while light 41 was configured as a red light when illuminated. Clearly, of 26 .course, if the battery is completely dead neither light 27 ~40 nor light 41 will illuminate.

1 As shown in Figure 2 , housing 12 is configured to 2 be concealingly received within the confines of a hand 3 60 to thereby substantially conceal, if desired, the 4 main body of electrical stimulation apparatus 10 while allowing electrodes 16 and 17 to protrude therefrom.

6 This concealment is made possible by the relatively 7 small size of electrical stimulation apparatus 10, that 8 is, having a length overall of, say, 5 to 8 centimeters, 9 a width of about 2 to 3 centimeters, and a thickness around one centimeter. Clearly, these dimensions are 11 only approximate but they do emphasize the fact that 12 electrical stimulation apparatus 10, particularly 13 housing 12 portion thereof, is easily concealed, if 14 desired, within the confines of hand 60. Another advantageous feature of electrical stimulation apparatus 16 10 is that it is provided with rounded corners 17 ~ externally to thereby render it less obtrusive when 18 either handled by hand 60 or carried within a pocket or 19 purse (not shown). Importantly, electrical stimulation apparatus l0 is specifically configured to be easily 21 carried, easily concealed during use, and simple to 22 operate to thereby specifically encourage the user to 23 carry electrical stimulator apparatus 10 at all times 24 and to use it whenever necessary regardless of the specific circumstances or surroundings. This is 26 important since it enables the user to immediately apply 27 electrical stimulation whenever the initial tactile 28 sensation preceding a herpes lesion formation are felt 1 by the user. Specifically, skin 62 is shown 2 schematically as having a lesion 64 forming thereon.

3 Electrodes 16 and 17 are being brought into contact with 4 skin 62 to bracket lesion 64, the contact points for electrodes 16 and 17 on skin 62 being shown at 66 and 6 6~7, respectively. It should be noted that lesion 64 is 7 shown herein as a visible lesion for purposes of 8 illustration, it being the preferred intent of this 9 invention to apply electrical stimulation to skin 62 :LO with electrical stimulator apparatus 10 before lesion 64 :L1 becomes visible.

:L2 Referring now to Figure 3, one embodiment of the :L3 circuitry for electrical stimulator apparatus 10 is :l4 shown generally at 70 and includes a battery 50, an :L5 electrical circuit 52 , and electrical leads 56 and 57 :l6 interconnecting electrical circuit 52 to electrodes 16 :l7 a.nd 17 respectively. Switch 20 is interposed in a lead :l8 54 between battery 50 and electrical circuit 52 and is :l9 manually operable to control the flow of electrical 20 energy from battery 50 to electrical circuit 52 thence :?1 t.o electrodes 16 and 17. Lights 40 and 41 are connected 22 across electrical leads 56 and 57. Light 40 provides a :>.3 visual indication that electrical energy is being :'4 supplied to electrodes 16 and 17. Light 41 is a low :>.5 battery indicator. The presence of lights 40 and 41 is :?6 important since the electrical energy supplied to 27 electrodes 16 and 17 is too weak to be detected by the :>.8 sensory perception of the user. Correspondingly, there 1 would be no indication to the user that the battery was 2 low if light 41 were not provided.

4 The Method The novel method of this invention is practiced by 6 the user (not shown) grasping electrical stimulator 7 apparatus l0 in hand 60 and removing closure 14 to 8 expose switch 20. The ends of electrodes 16 and 17 are 9 touched to the surface of skin 62 to bracket lesion 64 as shown at 66 and 67, respectively. The user then 11 depresses switch 20 to initiate the flow of electrical 12 current from battery 50 through electrical circuit 52 to 13 electrodes 16 and 17. Specifically, the closure of 14 switch 20 sends electrical energy from battery 50 through lead 54 to the circuitry of electrical circuit 16 52 which produces the desired electrical impulse to be 17 delivered through leads 56 and 57 to electrodes 16 and 18 17, respectively. In the simplified schematic of 19 circuitry of electronic circuit 70 as shown in Figure 3 light 40 is shown connected directly across leads 56 and 21 57. This configuration provides a direct indication to 22 the user that electrical energy is being delivered to 23 electrodes 16 and 17. In the event insufficient 24 electrical energy is being supplied by battery 50, light 41 will be illuminated as a low-battery indicator.

26 Passage of the resultant electrical energy through 27 lesion 64 results in an alteration of its cellular 28 structure so as to promote healing of lesion 64. While 1 the precise mechanism for the prouotion of healing of 2 lesion 64 using electrical stimulator apparatus l0 is 3 . nut fully understood, I have been able to demonstrate 4 significant improvements in the heal ing rates for lesion 64.
i 6 The present invention may be embodied in other .7~ specific forms without departing from its spirit or 8 essential characteristics. The de~~saribed embodiments 9 are to be considered in all respects only as illustrative and not restrictive. The scope of the 11 invention is, therefore, indicated by the appended 12 cJ.aims rather than by the foregoin.~ description. All 13 changes which come within the meaning and range of 14 ~ eduivalency of the claims are to be embraced within their scope.

.. . 2 'Y. ..

.:

;

Claims (13)

WHAT IS CLAIMED IS:
1. An apparatus for applying an electrical stimulus comprising:
a pair of electrodes extending from a housing, said pair of electrodes including a first electrode and a second electrode, each of said first electrode and said second electrode having an elongated body having a first end and a second end, said first end being configured with a smooth profile for contacting tissue, and second end including detent means for releasably engaging said elongated body to said housing;
a battery means in said housing for supplying electrical current to said electrodes; and switch means on said housing for controlling said electrical current to said electrodes;
wherein said housing includes a closure and an undercut section adjacent to said electrodes and to said switch means, said undercut section receiving said closure to enclose said electrodes and said switch means.
2. The apparatus defined in claim 1 wherein said housing includes clip means for releasably engaging said elongated body in said housing, said clip means also providing electrical contact with said elongated body.
3. The apparatus defined in claim 1 wherein said housing includes a first indicator light, said first indicator light illuminating when said switch means is activated and said battery is providing a predetermined amount of electrical current to said electrodes.
4. The apparatus defined in claim 1 wherein said housing includes a second indicator light, said second indicator light illuminating when said switch means is activated and said battery is not providing adequate electrical current to said electrodes.
5. The apparatus defined in claim 1 wherein said undercut section includes a recess formed around said switch means.
6. The apparatus defined in claim 1 wherein said closure is releasably mountable to said housing to provide a smooth external profile to said apparatus.
7. The apparatus defined in claim 1 wherein said housing includes a tether means for receiving a lanyard to tether said housing.
8. An apparatus for the application of electrical stimulation to tissue comprising:
a housing, said housing having a smooth external profile between a first end and a second end and an undercut section adjacent said first end of said housing;
a switch recessed within said undercut section of said housing;
a pair of electrodes extending from said first end of said housing, said electrodes each being formed with a cylindrical profile having a first end and a second end with a rounded tip on said first end and a sharpened tip on said second end, said sharpened tip including a recessed detent adjacent said sharpened tip, said housing including a spring clip for releasably engaging said detent;
a closure for said housing, said closure being received in said undercut section thereby providing a continuation of said smooth external profile of said housing across said closure and enclosing said electrodes;
a battery in said housing; and an electrical circuit in said housing electrically coupled between said battery and said electrodes, said switch means controlling electrical energy from said battery to said electrodes and through said electrical circuit.
9. The apparatus defined in claim 8 wherein said electrodes are releasably mounted to said housing.
10. The apparatus defined in claim 9 wherein said electrodes are each formed with a cylindrical profile having a rounded tip on one end and a sharpened tip with a recessed detent adjacent said sharpened tip, said housing including a spring clip for releasably engaging said detent.
11. The apparatus defined in claim 8 wherein said housing includes a tether means for tethering said housing.
12. The apparatus defined in claim 8 wherein said housing includes a light means for providing a visual indication that electrical energy is being delivered to said electrodes.
13. The apparatus defined in claim 12 wherein said light means includes a low-battery indicator for providing a visual indication that said battery is not delivering sufficient electrical energy.
CA002235365A 1995-10-20 1996-10-17 Apparatus and method for delivering electrical stimulus to tissue Expired - Fee Related CA2235365C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/545,945 US5607461A (en) 1995-10-20 1995-10-20 Apparatus and method for delivering electrical stimulus to tissue
US08/545,945 1995-10-20
PCT/US1996/016659 WO1997014472A1 (en) 1995-10-20 1996-10-17 Apparatus and method for delivering electrical stimulus to tissue

Publications (2)

Publication Number Publication Date
CA2235365A1 CA2235365A1 (en) 1997-04-24
CA2235365C true CA2235365C (en) 2005-08-09

Family

ID=24178183

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002235365A Expired - Fee Related CA2235365C (en) 1995-10-20 1996-10-17 Apparatus and method for delivering electrical stimulus to tissue

Country Status (14)

Country Link
US (1) US5607461A (en)
EP (1) EP0874660B1 (en)
JP (1) JP2000511066A (en)
KR (1) KR100476137B1 (en)
CN (1) CN1104915C (en)
AT (1) ATE268624T1 (en)
AU (1) AU1073597A (en)
CA (1) CA2235365C (en)
DE (1) DE69632692T2 (en)
ES (1) ES2219701T3 (en)
HK (1) HK1017626A1 (en)
IL (1) IL124121A (en)
MX (1) MX9803088A (en)
WO (1) WO1997014472A1 (en)

Families Citing this family (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6956032B1 (en) * 1986-04-18 2005-10-18 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
US5676648A (en) 1996-05-08 1997-10-14 The Aps Organization, Llp Iontophoretic drug delivery apparatus and method for use
US6385487B1 (en) 1996-05-08 2002-05-07 Biophoretic Therapeutic Systems, Llc Methods for electrokinetic delivery of medicaments
USD406899S (en) * 1996-05-09 1999-03-16 Kci Medical Limited Portable medical appliance for stimulating healing of wounds
US5792210A (en) * 1996-06-10 1998-08-11 Environmental Behavior Modification Inc. Electrical tongue stimulator and method for addiction treatment
US5861016A (en) * 1997-05-28 1999-01-19 Swing; Fred P. Method of wound healing using electrical stimulation and acupuncture needles
US6190404B1 (en) 1997-11-07 2001-02-20 Advanced Bio Prosthetic Surfaces, Ltd. Intravascular stent and method for manufacturing an intravascular stent
USRE37796E1 (en) 1997-12-16 2002-07-23 Biophoretic Therapeutic Systems, Llc Methods for iontophoretic delivery of antiviral agents
US6016451A (en) * 1998-06-24 2000-01-18 Sanchez-Rodarte; Salvador Neurological stabilizer device
US6148231A (en) * 1998-09-15 2000-11-14 Biophoretic Therapeutic Systems, Llc Iontophoretic drug delivery electrodes and method
US6594527B2 (en) 1998-09-18 2003-07-15 Nexmed Holdings, Inc. Electrical stimulation apparatus and method
US7127285B2 (en) * 1999-03-12 2006-10-24 Transport Pharmaceuticals Inc. Systems and methods for electrokinetic delivery of a substance
US6477410B1 (en) * 2000-05-31 2002-11-05 Biophoretic Therapeutic Systems, Llc Electrokinetic delivery of medicaments
US6792306B2 (en) * 2000-03-10 2004-09-14 Biophoretic Therapeutic Systems, Llc Finger-mounted electrokinetic delivery system for self-administration of medicaments and methods therefor
US6338347B1 (en) * 2000-04-04 2002-01-15 Yun-Yin Chung Blood circulation stimulator
US6389319B1 (en) 2000-06-01 2002-05-14 Justin J. Lee Tissue tensioning electrotheraphy device
US6801808B2 (en) 2000-06-01 2004-10-05 Justin J. Lee Tissue tensioning electrotherapy device
US6618625B2 (en) 2000-11-29 2003-09-09 Leon M. Silverstone Method and apparatus for treatment of viral diseases
US6819957B1 (en) 2001-08-29 2004-11-16 Tuan Vinh Le Electrical stimulation apparatus and method
SE0103293D0 (en) * 2001-10-03 2001-10-03 Painmatcher Ab Finger electrode and support structure
US7010353B2 (en) * 2002-01-07 2006-03-07 Ebi, L.P. Non-invasive capacitively coupled electrical stimulation device for treatment of soft tissue wounds
US7593775B2 (en) * 2002-01-15 2009-09-22 Therapeutic Innovations Sports equipment with resonant muscle stimulator for developing muscle strength
KR20030061993A (en) * 2002-01-15 2003-07-23 세인전자 주식회사 a curing device using micro-current
US7035691B2 (en) * 2002-01-15 2006-04-25 Therapeutic Innovations, Inc. Resonant muscle stimulator
US20040049241A1 (en) * 2002-09-10 2004-03-11 Therapeutic Innovations, Inc. Distributed muscle stimulator
US6766199B2 (en) 2002-10-10 2004-07-20 Proventure (Far East), Limited Skin/hair treatment method and system
US20040236385A1 (en) * 2003-01-31 2004-11-25 Therapeutic Innovations, Inc. Rectal resonant muscle stimulator
US7228184B2 (en) * 2003-02-22 2007-06-05 Chester Heath Viral-inhibiting method
US7584001B2 (en) * 2003-07-17 2009-09-01 Beck Kent F Electrical epidermal stimulation device
US20050049654A1 (en) * 2003-08-28 2005-03-03 Peter Lathrop Ultralight pre-programmed microprocessor based electrotherapy technology
US7813809B2 (en) * 2004-06-10 2010-10-12 Medtronic, Inc. Implantable pulse generator for providing functional and/or therapeutic stimulation of muscles and/or nerves and/or central nervous system tissue
GB2407982B (en) * 2003-11-11 2008-05-14 Ricardo Antonio Cuminetti Hand holdable relaxation device
US20050125040A1 (en) * 2003-12-09 2005-06-09 Peter Lathrop Method and apparatus for treating viral diseases
US7120499B2 (en) * 2004-02-12 2006-10-10 Ndi Medical, Llc Portable percutaneous assemblies, systems and methods for providing highly selective functional or therapeutic neuromuscular stimulation
EP1718360B1 (en) 2004-02-12 2016-05-04 ProVenture (Far East) Limited Skin/hair treatment system
US8467875B2 (en) 2004-02-12 2013-06-18 Medtronic, Inc. Stimulation of dorsal genital nerves to treat urologic dysfunctions
US7376467B2 (en) * 2004-02-12 2008-05-20 Ndi Medical, Inc. Portable assemblies, systems and methods for providing functional or therapeutic neuromuscular stimulation
US8086318B2 (en) * 2004-02-12 2011-12-27 Ndi Medical, Llc Portable assemblies, systems, and methods for providing functional or therapeutic neurostimulation
US7761167B2 (en) 2004-06-10 2010-07-20 Medtronic Urinary Solutions, Inc. Systems and methods for clinician control of stimulation systems
US8165692B2 (en) * 2004-06-10 2012-04-24 Medtronic Urinary Solutions, Inc. Implantable pulse generator power management
US8195304B2 (en) 2004-06-10 2012-06-05 Medtronic Urinary Solutions, Inc. Implantable systems and methods for acquisition and processing of electrical signals
US9308382B2 (en) * 2004-06-10 2016-04-12 Medtronic Urinary Solutions, Inc. Implantable pulse generator systems and methods for providing functional and/or therapeutic stimulation of muscles and/or nerves and/or central nervous system tissue
US9205255B2 (en) * 2004-06-10 2015-12-08 Medtronic Urinary Solutions, Inc. Implantable pulse generator systems and methods for providing functional and/or therapeutic stimulation of muscles and/or nerves and/or central nervous system tissue
US8082038B2 (en) * 2004-07-09 2011-12-20 Ebi, Llc Method for treating degenerative disc disease using noninvasive capacitively coupled electrical stimulation device
US20110054346A1 (en) * 2005-03-01 2011-03-03 Checkpoint Surgical, Llc Systems and methods for Intra-operative semi-quantitative threshold neural response testing related applications
JP2008539051A (en) * 2005-04-28 2008-11-13 キャロル コール カンパニー Micro dermal tone skin stimulator
US20070276449A1 (en) * 2005-06-15 2007-11-29 Med-Lectric Corporation Interactive transcutaneous electrical nerve stimulation device
US20070016277A1 (en) * 2005-07-05 2007-01-18 Carol Karat Lip augmentation device
US9480846B2 (en) 2006-05-17 2016-11-01 Medtronic Urinary Solutions, Inc. Systems and methods for patient control of stimulation systems
US20070282400A1 (en) * 2006-06-02 2007-12-06 Kendall Jay Gorham Combination medical therapy device that integrates: electrical stimulation, light therapy, heat, pressure, and vibration
US7877152B2 (en) * 2006-07-31 2011-01-25 JusJas LLC Bipolar stimulation/recording device with widely spaced electrodes
US20090287284A1 (en) * 2008-05-16 2009-11-19 Avazzia, Inc. Y-shaped electrodes for use with electro-stimulation device
US20090326612A1 (en) * 2008-06-26 2009-12-31 Michael J. Distler Electronic biofeedback stimulation device
AU2009277036B2 (en) 2008-08-01 2016-03-03 Spr Therapeutics, Inc. Portable assemblies, systems, and methods for providing functional or therapeutic neurostimulation
US20100099942A1 (en) * 2008-10-20 2010-04-22 Lucas Portelli Method and apparatus for electromagnetic human and animal immune stimulation and/or repair systems activation
US7983747B2 (en) 2008-10-28 2011-07-19 Silverstone Leon M Non-invasive method and apparatus for the treatment of viral infections
CN103002946B (en) * 2010-05-02 2014-11-19 内瓦孚有限公司 Modulating function of the facial nerve system or related neural structures via the ear
US9272157B2 (en) 2010-05-02 2016-03-01 Nervive, Inc. Modulating function of neural structures near the ear
US8825174B2 (en) 2010-06-27 2014-09-02 Integrity Research Institute Therapeutic electric antioxidant clothing apparatus and method
US9821159B2 (en) 2010-11-16 2017-11-21 The Board Of Trustees Of The Leland Stanford Junior University Stimulation devices and methods
CN103313754B (en) 2010-11-16 2015-09-30 小利兰·斯坦福大学理事会 Be used for the treatment of the system and method for xerophthalmia
EP2804663B1 (en) * 2012-01-16 2019-03-27 Swiss SPA System Ltd. Hand-held device for electrically assisted dermal treatment
USD722383S1 (en) 2012-05-01 2015-02-10 Carol Cole Company Skin clearing and toning device
CN204147427U (en) * 2012-11-26 2015-02-11 塞恩克公司 Wearable electrocutaneous stimulation equipment
US10485972B2 (en) 2015-02-27 2019-11-26 Thync Global, Inc. Apparatuses and methods for neuromodulation
US11033731B2 (en) 2015-05-29 2021-06-15 Thync Global, Inc. Methods and apparatuses for transdermal electrical stimulation
US10814131B2 (en) 2012-11-26 2020-10-27 Thync Global, Inc. Apparatuses and methods for neuromodulation
US10537703B2 (en) 2012-11-26 2020-01-21 Thync Global, Inc. Systems and methods for transdermal electrical stimulation to improve sleep
DE202013000390U1 (en) * 2013-01-16 2013-04-26 Swiss Spa System Ltd. In one hand durable device for electrically assisted skin treatment
US9717627B2 (en) 2013-03-12 2017-08-01 Oculeve, Inc. Implant delivery devices, systems, and methods
US8996137B2 (en) 2013-04-19 2015-03-31 Oculeve, Inc. Nasal stimulation devices and methods
US10065047B2 (en) 2013-05-20 2018-09-04 Nervive, Inc. Coordinating emergency treatment of cardiac dysfunction and non-cardiac neural dysfunction
US10293161B2 (en) 2013-06-29 2019-05-21 Thync Global, Inc. Apparatuses and methods for transdermal electrical stimulation of nerves to modify or induce a cognitive state
US9770583B2 (en) 2014-02-25 2017-09-26 Oculeve, Inc. Polymer formulations for nasolacrimal stimulation
USD739541S1 (en) 2014-05-12 2015-09-22 Carol Cole Company Skin clearing and toning device
WO2016015025A1 (en) 2014-07-25 2016-01-28 Oculeve, Inc. Stimulation patterns for treating dry eye
ES2809599T3 (en) 2014-10-22 2021-03-04 Oculeve Inc Stimulation devices to treat dry eyes
US10207108B2 (en) 2014-10-22 2019-02-19 Oculeve, Inc. Implantable nasal stimulator systems and methods
US9764150B2 (en) 2014-10-22 2017-09-19 Oculeve, Inc. Contact lens for increasing tear production
US11534608B2 (en) 2015-01-04 2022-12-27 Ist, Llc Methods and apparatuses for transdermal stimulation of the outer ear
WO2016109851A1 (en) 2015-01-04 2016-07-07 Thync, Inc. Methods and apparatuses for transdermal stimulation of the outer ear
USD764172S1 (en) * 2015-01-22 2016-08-23 Wenzhou Onicare Electrical Technology, Co. Sonic face brush
USD752237S1 (en) 2015-03-03 2016-03-22 Carol Cole Company Skin toning device
JP6860503B2 (en) 2015-05-05 2021-04-14 コスモ ハラランビディス, Device for electrical stimulation of periodontal complex and surrounding tissue
US11103696B2 (en) 2015-05-05 2021-08-31 Cosmo Haralambidis Device for electrical stimulation of peridontal complex and surrounding tissue
US10426958B2 (en) 2015-12-04 2019-10-01 Oculeve, Inc. Intranasal stimulation for enhanced release of ocular mucins and other tear proteins
WO2017106411A1 (en) 2015-12-15 2017-06-22 Cerevast Medical, Inc. Electrodes having surface exclusions
WO2017106878A1 (en) 2015-12-18 2017-06-22 Thync Global, Inc. Apparatuses and methods for transdermal electrical stimulation of nerves to modify or induce a cognitive state
US10252048B2 (en) 2016-02-19 2019-04-09 Oculeve, Inc. Nasal stimulation for rhinitis, nasal congestion, and ocular allergies
WO2017192572A1 (en) 2016-05-02 2017-11-09 Oculeve, Inc. Intranasal stimulation for treatment of meibomian gland disease and blepharitis
US10646708B2 (en) 2016-05-20 2020-05-12 Thync Global, Inc. Transdermal electrical stimulation at the neck
RU2019118600A (en) 2016-12-02 2021-01-11 Окулив, Инк. APPARATUS AND METHOD FOR MAKING DRY EYE SYNDROME PREDICTION AND TREATMENT RECOMMENDATIONS
USD865990S1 (en) * 2017-06-13 2019-11-05 Skinscience Co., Ltd. Skin care device
US11278724B2 (en) 2018-04-24 2022-03-22 Thync Global, Inc. Streamlined and pre-set neuromodulators
USD854699S1 (en) 2018-05-15 2019-07-23 Carol Cole Company Elongated skin toning device
USD904629S1 (en) * 2018-08-16 2020-12-08 Spr Therapeutics, Inc. Electrical stimulator
USD961785S1 (en) * 2019-10-16 2022-08-23 Hoolest Performance Technologies, Inc. Electrical stimulation device
USD953553S1 (en) 2020-02-19 2022-05-31 Carol Cole Company Skin toning device
US11026664B1 (en) 2020-04-22 2021-06-08 Slobodan Petrovic Electrochemical device for virus detection and treatment
USD957664S1 (en) 2020-07-29 2022-07-12 Carol Cole Company Skin toning device

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4033356A (en) * 1975-08-20 1977-07-05 Hakuju Institute For Health Science Co., Ltd. Apparatus for therapeutical treatment and stimulation of muscles by low-frequency oscillating electric current
US4112923A (en) * 1976-08-24 1978-09-12 Tomecek Jerry J Antonomic transcutaneous affect device
US4770328A (en) * 1982-12-16 1988-09-13 Medtronic, Inc. Tissue stimulator casing
AT385664B (en) 1985-07-31 1988-05-10 Hepax Ltd ELECTROMEDICAL THERAPY DEVICE
DE3650729T2 (en) 1985-12-04 2000-05-04 Hisamitsu Pharmaceutical Co COMPACT LOW-FREQUENCY MEDICINE ARRANGEMENT
US4803986A (en) * 1987-04-24 1989-02-14 Minnesota Mining And Manufacturing Company Ergonometric transcutaneous electrical nerve stimulator
JPS6456060A (en) 1987-08-27 1989-03-02 Hayashibara Takeshi Low frequency medical treatment device
US5070605A (en) * 1988-04-22 1991-12-10 Medtronic, Inc. Method for making an in-line pacemaker connector system
US4934367A (en) * 1988-04-22 1990-06-19 Medtronic, Inc. In-line pacemaker connector system
US4917092A (en) * 1988-07-13 1990-04-17 Medical Designs, Inc. Transcutaneous nerve stimulator for treatment of sympathetic nerve dysfunction
US5107835A (en) 1989-05-22 1992-04-28 Physiodynamics Electrotherapeutic treatment
US5133352A (en) * 1990-04-12 1992-07-28 Kent, Lathrop And Johnston Method for treating herpes simplex
US5254081A (en) * 1991-02-01 1993-10-19 Empi, Inc. Multiple site drug iontophoresis electronic device and method

Also Published As

Publication number Publication date
KR19990066940A (en) 1999-08-16
DE69632692T2 (en) 2005-06-09
EP0874660A1 (en) 1998-11-04
EP0874660A4 (en) 2000-11-15
EP0874660B1 (en) 2004-06-09
AU1073597A (en) 1997-05-07
US5607461A (en) 1997-03-04
CA2235365A1 (en) 1997-04-24
IL124121A (en) 2003-10-31
CN1104915C (en) 2003-04-09
MX9803088A (en) 1998-12-31
ATE268624T1 (en) 2004-06-15
DE69632692D1 (en) 2004-07-15
JP2000511066A (en) 2000-08-29
HK1017626A1 (en) 1999-11-26
ES2219701T3 (en) 2004-12-01
CN1204268A (en) 1999-01-06
KR100476137B1 (en) 2005-08-18
WO1997014472A1 (en) 1997-04-24

Similar Documents

Publication Publication Date Title
CA2235365C (en) Apparatus and method for delivering electrical stimulus to tissue
US10328260B2 (en) Electrical stimulation device and method for therapeutic treatment and pain management
JP3405986B2 (en) Device for treating inflammatory skin changes that are present at an early stage
US5423874A (en) Patch for applying pain reducing electrical energy to the body
US6083250A (en) Apparatus and method for inhibiting lesion formation by selectively treating the prodromal stage of the lesion with a pulsatile electrical stimulation
EP0500552B1 (en) Nausea control device
US6445955B1 (en) Miniature wireless transcutaneous electrical neuro or muscular-stimulation unit
US20090171418A1 (en) Apparatus for Non-Invasive Stimulation of an Animal
CA2253671A1 (en) Iontophoretic drug delivery apparatus and method for use
AU4096193A (en) Medical device
WO2014150090A1 (en) Oral neural stimulator
KR200365069Y1 (en) A Device to subdue drowsiness
KR200231096Y1 (en) Insulin patch device
WO2001089628A1 (en) Apparatus and method for inhibiting lesion formation
JP2607040Y2 (en) Electric therapy equipment
CN1144702A (en) Electronic acupoint therapeutic apparatus
JPH0674149U (en) Plaster shaped low frequency therapy device

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed