CA2211727A1 - Large area submucosal graft constructs and method for making the same - Google Patents

Large area submucosal graft constructs and method for making the same

Info

Publication number
CA2211727A1
CA2211727A1 CA002211727A CA2211727A CA2211727A1 CA 2211727 A1 CA2211727 A1 CA 2211727A1 CA 002211727 A CA002211727 A CA 002211727A CA 2211727 A CA2211727 A CA 2211727A CA 2211727 A1 CA2211727 A1 CA 2211727A1
Authority
CA
Canada
Prior art keywords
tissue
constructs
graft constructs
making
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002211727A
Other languages
French (fr)
Other versions
CA2211727C (en
Inventor
Umesh H. Patel
Michael C. Hiles
Bryan A. Whitson
Boyle Cheng
Stephen F. Badylak
Klod Kokini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
METHODIST HEALTH GROUP Inc
Purdue Research Foundation
Original Assignee
Purdue Research Foundation
Umesh H. Patel
Michael C. Hiles
Bryan A. Whitson
Boyle Cheng
Stephen F. Badylak
Klod Kokini
Methodist Health Group, Inc.
Methodist Hospital Of Indiana, Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Research Foundation, Umesh H. Patel, Michael C. Hiles, Bryan A. Whitson, Boyle Cheng, Stephen F. Badylak, Klod Kokini, Methodist Health Group, Inc., Methodist Hospital Of Indiana, Incorporated filed Critical Purdue Research Foundation
Publication of CA2211727A1 publication Critical patent/CA2211727A1/en
Application granted granted Critical
Publication of CA2211727C publication Critical patent/CA2211727C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/38—Stomach; Intestine; Goblet cells; Oral mucosa; Saliva
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3629—Intestinal tissue, e.g. small intestinal submucosa
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Multi-laminar tissue graft constructs, pseudoisotropic graft constructs and a method of preparing such constructs are described. Multi-laminar tissue graft constructs are prepared by fusing partially overlapped strips of submucosa tissue into a unitary graft construct by compressing the tissue under dehydrating conditions. Pseudoisotropic tissue graft constructs are prepared by overlapping a first strip of submucosa tissue with at least two strips of submucosa tissue orientated so that the longitudinal axis of each strip forms an angle of about 180~/N with the longitudinal axes of at least two other strips of submucosal tissue.
CA002211727A 1995-04-07 1996-04-05 Large area submucosal graft constructs and method for making the same Expired - Lifetime CA2211727C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/418,515 1995-04-07
US08/418,515 US5711969A (en) 1995-04-07 1995-04-07 Large area submucosal tissue graft constructs
PCT/US1996/004721 WO1996031226A1 (en) 1995-04-07 1996-04-05 Large area submucosal graft constructs and method for making the same

Publications (2)

Publication Number Publication Date
CA2211727A1 true CA2211727A1 (en) 1996-10-10
CA2211727C CA2211727C (en) 2002-02-26

Family

ID=23658441

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002211727A Expired - Lifetime CA2211727C (en) 1995-04-07 1996-04-05 Large area submucosal graft constructs and method for making the same

Country Status (10)

Country Link
US (3) US5711969A (en)
EP (1) EP0821590B1 (en)
JP (1) JP3061643B2 (en)
AR (1) AR001564A1 (en)
AT (1) ATE305792T1 (en)
AU (1) AU690455B2 (en)
CA (1) CA2211727C (en)
DE (1) DE69635241T2 (en)
DK (1) DK0821590T3 (en)
WO (1) WO1996031226A1 (en)

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AR001564A1 (en) 1997-11-26
US5955110A (en) 1999-09-21
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US5885619A (en) 1999-03-23
JPH10506125A (en) 1998-06-16
EP0821590A4 (en) 2000-05-24
WO1996031226A1 (en) 1996-10-10
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CA2211727C (en) 2002-02-26
EP0821590B1 (en) 2005-10-05

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