CA2195186A1 - Systems and methods for estimating platelet counts - Google Patents

Systems and methods for estimating platelet counts

Info

Publication number
CA2195186A1
CA2195186A1 CA002195186A CA2195186A CA2195186A1 CA 2195186 A1 CA2195186 A1 CA 2195186A1 CA 002195186 A CA002195186 A CA 002195186A CA 2195186 A CA2195186 A CA 2195186A CA 2195186 A1 CA2195186 A1 CA 2195186A1
Authority
CA
Canada
Prior art keywords
spleen
systems
methods
platelets
plt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002195186A
Other languages
French (fr)
Other versions
CA2195186C (en
Inventor
Richard I. Brown
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fenwal Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2195186A1 publication Critical patent/CA2195186A1/en
Application granted granted Critical
Publication of CA2195186C publication Critical patent/CA2195186C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/38—Removing constituents from donor blood and storing or returning remainder to body, e.g. for transfusion
    • A61M1/382—Optimisation of blood component yield
    • A61M1/385—Optimisation of blood component yield taking into account of the patient characteristics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3672—Means preventing coagulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A61M1/3696—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/0209—Multiple bag systems for separating or storing blood components
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0415—Plasma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0427—Platelets; Thrombocytes

Abstract

Systems and methods take into account that the spleen normally holds a number of platelets in reserve out of circulation. During blood procesing, the spleen releases these platelets into the donor's circulatory system, making them available for collection. The systems and methods estimate the number of platelets N SPLEEN held in reserve by the spleen in a human body. The systems and methods derive a splenic mobilization function Spleen, which can be expressed as a function of a precount of platelets Plt PRE. The systems and methods estimate N SPLEEN where: N SPLEEN = Spleen-1 x Plt PRE x DonVol where DonVol is blood volume in the body. The systems and methods can also estimate the total number of platelets N PLT in a human body, taking the Spleen function into account, where: N PLT
= Plt PRE x Spleen x DonVol.
CA002195186A 1995-06-07 1996-05-22 Systems and methods for estimating platelet counts Expired - Lifetime CA2195186C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/480,601 1995-06-07
US08/480,601 US5759413A (en) 1995-06-07 1995-06-07 Systems and method for estimating platelet counts using a spleen mobilization function
PCT/US1996/007672 WO1996040310A1 (en) 1995-06-07 1996-05-22 Systems and methods for estimating platelet counts

Publications (2)

Publication Number Publication Date
CA2195186A1 true CA2195186A1 (en) 1996-12-19
CA2195186C CA2195186C (en) 2009-04-07

Family

ID=23908588

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002195186A Expired - Lifetime CA2195186C (en) 1995-06-07 1996-05-22 Systems and methods for estimating platelet counts

Country Status (9)

Country Link
US (2) US5759413A (en)
EP (1) EP0777505B1 (en)
JP (1) JP3994292B2 (en)
AU (1) AU701419B2 (en)
CA (1) CA2195186C (en)
DE (1) DE69636969T2 (en)
ES (1) ES2284171T3 (en)
NO (1) NO970540L (en)
WO (1) WO1996040310A1 (en)

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US7211037B2 (en) * 2002-03-04 2007-05-01 Therakos, Inc. Apparatus for the continuous separation of biological fluids into components and method of using same
US7186230B2 (en) * 2002-03-04 2007-03-06 Therakos, Inc Method and apparatus for the continuous separation of biological fluids into components
US20050049539A1 (en) * 2003-09-03 2005-03-03 O'hara Gerald P. Control system for driving fluids through an extracorporeal blood circuit
US20050241545A1 (en) * 2004-04-28 2005-11-03 Vargo Richard F Jr Methods of extending the shelf life of and revitalizing lightweight beads for use in cement compositions
US7476209B2 (en) * 2004-12-21 2009-01-13 Therakos, Inc. Method and apparatus for collecting a blood component and performing a photopheresis treatment
US9733805B2 (en) 2012-06-26 2017-08-15 Terumo Bct, Inc. Generating procedures for entering data prior to separating a liquid into components
US10391213B2 (en) 2016-06-08 2019-08-27 Fenwal, Inc. Systems and methods for therapeutic platelet depletion

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Also Published As

Publication number Publication date
CA2195186C (en) 2009-04-07
EP0777505B1 (en) 2007-03-14
ES2284171T3 (en) 2007-11-01
AU701419B2 (en) 1999-01-28
JPH10506565A (en) 1998-06-30
NO970540D0 (en) 1997-02-06
US6197202B1 (en) 2001-03-06
DE69636969D1 (en) 2007-04-26
WO1996040310A1 (en) 1996-12-19
EP0777505A4 (en) 2000-07-26
AU6024296A (en) 1996-12-30
DE69636969T2 (en) 2007-12-20
EP0777505A1 (en) 1997-06-11
US5759413A (en) 1998-06-02
NO970540L (en) 1997-04-04
JP3994292B2 (en) 2007-10-17

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Effective date: 20160524