CA2194582A1 - Novel process for the production of biologically active dimeric protein - Google Patents

Novel process for the production of biologically active dimeric protein

Info

Publication number
CA2194582A1
CA2194582A1 CA002194582A CA2194582A CA2194582A1 CA 2194582 A1 CA2194582 A1 CA 2194582A1 CA 002194582 A CA002194582 A CA 002194582A CA 2194582 A CA2194582 A CA 2194582A CA 2194582 A1 CA2194582 A1 CA 2194582A1
Authority
CA
Canada
Prior art keywords
biologically active
production
novel process
dimeric protein
active dimeric
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002194582A
Other languages
French (fr)
Other versions
CA2194582C (en
Inventor
Nico Cerletti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2194582A1 publication Critical patent/CA2194582A1/en
Application granted granted Critical
Publication of CA2194582C publication Critical patent/CA2194582C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

The present invention relates to a folding process for the preparation of biologically active, dimeric TGF-.beta. (transforming Growth Factor type .beta.)-like protein.
CA002194582A 1994-07-25 1995-07-12 Novel process for the production of biologically active dimeric protein Expired - Fee Related CA2194582C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP94810438.5 1994-07-25
EP94810438 1994-07-25
PCT/EP1995/002718 WO1996003432A1 (en) 1994-07-25 1995-07-12 Novel process for the production of biologically active dimeric protein

Publications (2)

Publication Number Publication Date
CA2194582A1 true CA2194582A1 (en) 1996-02-08
CA2194582C CA2194582C (en) 2008-09-02

Family

ID=8218292

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002194582A Expired - Fee Related CA2194582C (en) 1994-07-25 1995-07-12 Novel process for the production of biologically active dimeric protein

Country Status (19)

Country Link
US (1) US6057430A (en)
EP (1) EP0775159B1 (en)
JP (2) JP3923516B2 (en)
KR (1) KR100432839B1 (en)
AT (1) ATE207933T1 (en)
AU (1) AU690311B2 (en)
CA (1) CA2194582C (en)
DE (1) DE69523605T2 (en)
DK (1) DK0775159T3 (en)
ES (1) ES2166401T3 (en)
FI (1) FI118083B (en)
HU (1) HU222830B1 (en)
IL (1) IL114701A (en)
NO (1) NO316926B1 (en)
NZ (1) NZ290373A (en)
PT (1) PT775159E (en)
TW (1) TW440566B (en)
WO (1) WO1996003432A1 (en)
ZA (1) ZA956138B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW517059B (en) * 1994-07-25 2003-01-11 Ciba Geigy Ag New process for the production of biologically active protein
JP4019432B2 (en) * 1995-12-21 2007-12-12 味の素株式会社 Method for refolding human activin A
DE19906096A1 (en) 1999-02-13 2000-08-17 Walter Sebald Protein with a heparin-binding epitope
AU2001244647A1 (en) * 2000-03-30 2001-10-15 Takeda Chemical Industries Ltd. Process for producing recombinant protein
EP1292330A1 (en) * 2000-03-31 2003-03-19 Vaccine Chip Technology APS Immunostimulating properties of a fragment of tgf- beta
US7572474B2 (en) 2005-06-01 2009-08-11 Mead Johnson Nutrition Company Method for simulating the functional attributes of human milk oligosaccharides in formula-fed infants
US8075934B2 (en) * 2008-10-24 2011-12-13 Mead Johnson Nutrition Company Nutritional composition with improved digestibility
GB0514262D0 (en) * 2005-07-12 2005-08-17 Renovo Ltd Promotion of epithelial regeneration
GB0604966D0 (en) 2006-03-11 2006-04-19 Renovo Ltd Medicaments and proteins
GB0604938D0 (en) * 2006-03-11 2006-04-19 Renovo Ltd Proteins, nucleic acids and medicaments
GB0604964D0 (en) 2006-03-11 2006-04-19 Renovo Ltd Protein folding
GB0617816D0 (en) * 2006-09-11 2006-10-18 Renovo Ltd Nucleic acids and methods of protein expression
US8986769B2 (en) 2008-10-24 2015-03-24 Mead Johnson Nutrition Company Methods for preserving endogenous TGF-β
CA3048735A1 (en) 2016-12-30 2018-07-05 Biogend Therapeutics Co., Ltd. Recombinant polypeptides, compositions, and methods thereof
CN113348000A (en) * 2018-09-17 2021-09-03 德克萨斯大学体系董事会 Compositions and methods for treating bone injury

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4731440A (en) * 1985-02-22 1988-03-15 Monsanto Company Method of somatotropin solubilization using dimethylsulfone and naturation
JPH0759598B2 (en) * 1986-02-14 1995-06-28 藤沢薬品工業株式会社 Method for producing human insulin-like growth factor (I)
AU626524B2 (en) * 1987-05-29 1992-08-06 Bristol-Myers Squibb Company Cloning and expression of simian transforming growth factor- beta 1
US5061786A (en) * 1989-05-25 1991-10-29 Genentech, Inc. Biologically active polypeptides based on transforming growth factor-β
GB8927546D0 (en) * 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
US5144006A (en) * 1991-06-13 1992-09-01 The Rockefeller University Oxidative folding of peptide and protein substrates using hydrocarbon sulfoxides
AU2738392A (en) * 1991-11-11 1993-05-13 Ciba-Geigy Ag Novel hybrid transforming growth factors

Also Published As

Publication number Publication date
FI118083B (en) 2007-06-29
IL114701A0 (en) 1995-11-27
EP0775159A1 (en) 1997-05-28
NO316926B1 (en) 2004-06-28
IL114701A (en) 2005-11-20
KR100432839B1 (en) 2004-08-30
CA2194582C (en) 2008-09-02
ES2166401T3 (en) 2002-04-16
NO970325D0 (en) 1997-01-24
JP2007031453A (en) 2007-02-08
ZA956138B (en) 1996-03-07
NZ290373A (en) 1998-04-27
DE69523605T2 (en) 2002-07-11
FI970229A (en) 1997-01-20
HUT76668A (en) 1997-10-28
EP0775159B1 (en) 2001-10-31
JPH11505506A (en) 1999-05-21
FI970229A0 (en) 1997-01-20
NO970325L (en) 1997-03-06
JP3923516B2 (en) 2007-06-06
WO1996003432A1 (en) 1996-02-08
AU3109595A (en) 1996-02-22
DK0775159T3 (en) 2002-02-11
DE69523605D1 (en) 2001-12-06
ATE207933T1 (en) 2001-11-15
TW440566B (en) 2001-06-16
HU222830B1 (en) 2003-11-28
US6057430A (en) 2000-05-02
PT775159E (en) 2002-04-29
AU690311B2 (en) 1998-04-23

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