CA2191584A1 - Manufacture of autogenous replacement body parts - Google Patents

Manufacture of autogenous replacement body parts

Info

Publication number
CA2191584A1
CA2191584A1 CA002191584A CA2191584A CA2191584A1 CA 2191584 A1 CA2191584 A1 CA 2191584A1 CA 002191584 A CA002191584 A CA 002191584A CA 2191584 A CA2191584 A CA 2191584A CA 2191584 A1 CA2191584 A1 CA 2191584A1
Authority
CA
Canada
Prior art keywords
manufacture
replacement body
body parts
autogenous
autogenous replacement
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002191584A
Other languages
French (fr)
Other versions
CA2191584C (en
Inventor
Roger K. Khouri
Kuber T. Sampath
David C. Rueger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stryker Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22960109&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2191584(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Priority to CA002372690A priority Critical patent/CA2372690A1/en
Publication of CA2191584A1 publication Critical patent/CA2191584A1/en
Application granted granted Critical
Publication of CA2191584C publication Critical patent/CA2191584C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/22Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3608Bone, e.g. demineralised bone matrix [DBM], bone powder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3612Cartilage, synovial fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645Connective tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645Connective tissue
    • A61L27/3654Cartilage, e.g. meniscus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/06Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus

Abstract

Disclosed are matrix materials, methods, and devices for manufacture in vivo of autogenous replacement body parts comprising plural distinct tissues. In one embodiment, the replacement body part a a skeletal joint and the new plural distinct tissues include bone and articular cartilage.
CA002191584A 1994-06-03 1995-06-02 Manufacture of autogenous replacement body parts Expired - Lifetime CA2191584C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002372690A CA2372690A1 (en) 1994-06-03 1995-06-02 Manufacture of autogenous replacement body parts

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US253,398 1994-06-03
US08/253,398 US5906827A (en) 1994-06-03 1994-06-03 Matrix for the manufacture of autogenous replacement body parts
PCT/US1995/006724 WO1995033502A1 (en) 1994-06-03 1995-06-02 Manufacture of autogenous replacement body parts

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA002372690A Division CA2372690A1 (en) 1994-06-03 1995-06-02 Manufacture of autogenous replacement body parts

Publications (2)

Publication Number Publication Date
CA2191584A1 true CA2191584A1 (en) 1995-12-14
CA2191584C CA2191584C (en) 2002-05-28

Family

ID=22960109

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002191584A Expired - Lifetime CA2191584C (en) 1994-06-03 1995-06-02 Manufacture of autogenous replacement body parts

Country Status (8)

Country Link
US (5) US5906827A (en)
EP (1) EP0762903B2 (en)
JP (1) JP3504950B2 (en)
AT (1) ATE249849T1 (en)
AU (1) AU702220C (en)
CA (1) CA2191584C (en)
DE (1) DE69531779T3 (en)
WO (1) WO1995033502A1 (en)

Families Citing this family (140)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6919308B2 (en) * 1988-04-08 2005-07-19 Stryker Corporation Osteogenic devices
US6586388B2 (en) 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
US5266683A (en) * 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US20070166353A1 (en) * 1988-04-08 2007-07-19 Stryker Corporation Osteogenic proteins
EP1225225A3 (en) * 1988-04-08 2003-01-08 Stryker Corporation Osteogenic devices
US7056882B2 (en) * 1991-03-11 2006-06-06 Curis, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US20080233170A1 (en) * 1992-02-21 2008-09-25 Stryker Corporation Osteogenic Proteins
US5906827A (en) * 1994-06-03 1999-05-25 Creative Biomolecules, Inc. Matrix for the manufacture of autogenous replacement body parts
US6123727A (en) * 1995-05-01 2000-09-26 Massachusetts Institute Of Technology Tissue engineered tendons and ligaments
AU699918B2 (en) * 1995-06-05 1998-12-17 Genetics Institute, Llc Methods and compositions for healing and repair of connective tissue attachment
US5674292A (en) 1995-06-07 1997-10-07 Stryker Corporation Terminally sterilized osteogenic devices and preparation thereof
WO1998030141A2 (en) * 1997-01-09 1998-07-16 Cohesion Technologies, Inc. Devices for tissue repair and methods for preparation and use thereof
AU779278B2 (en) * 1997-02-07 2005-01-13 Stryker Corporation Matrix-free osteogenic devices, implants and methods of use thereof
CA2280931C (en) * 1997-02-07 2009-05-05 Stryker Corporation Matrix-free osteogenic devices, implants and methods of use thereof
US6235316B1 (en) * 1997-04-04 2001-05-22 Barnes-Jewish Hospital Neocartilage and methods of use
US20030032586A1 (en) * 1997-05-15 2003-02-13 David C. Rueger Compositions for morphogen-induced osteogenesis
US6482584B1 (en) 1998-11-13 2002-11-19 Regeneration Technologies, Inc. Cyclic implant perfusion cleaning and passivation process
US20010031254A1 (en) * 1998-11-13 2001-10-18 Bianchi John R. Assembled implant
AU1706499A (en) * 1997-12-04 1999-06-16 Curis, Inc. Maintenance of smooth muscle integrity by morphogenic proteins
CA2314821A1 (en) * 1997-12-17 1999-06-24 Creative Biomolecules, Inc. Methods for maintaining or restoring tissue-appropriate phenotype of soft tissue cells
US6371992B1 (en) * 1997-12-19 2002-04-16 The Regents Of The University Of California Acellular matrix grafts: preparation and use
DE19803673A1 (en) 1998-01-30 1999-08-05 Norbert M Dr Meenen Biohybrid joint replacement
US6933326B1 (en) * 1998-06-19 2005-08-23 Lifecell Coporation Particulate acellular tissue matrix
US6958149B2 (en) 1998-10-06 2005-10-25 Stryker Corporation Repair of larynx, trachea, and other fibrocartilaginous tissues
CA2346375C (en) * 1998-10-06 2013-04-23 Rush-Presbyterian-St. Luke's Medical Center Method for the treatment of chemonucleolysis
US7572440B2 (en) 1999-07-30 2009-08-11 Stryker Corporation Method for repairing a defect in an intervertebral disc
EP1649865B1 (en) * 1998-10-06 2012-06-13 Stryker Corporation GDF-5 for use in repairing a nonarticular cartilage defect in an intervertebral disc
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
US6793677B2 (en) * 1999-08-13 2004-09-21 Bret A. Ferree Method of providing cells and other biologic materials for transplantation
CA2393776C (en) 1999-12-15 2009-02-10 Sulzer Orthopedics Ltd. Preparation for repairing cartilage defects or cartilage/bone defects in human or animal joints
AR027685A1 (en) 2000-03-22 2003-04-09 Synthes Ag METHOD AND METHOD FOR CARRYING OUT
ITVI20000025U1 (en) * 2000-04-07 2001-10-07 Tecres Spa TEMPORARY SPACER DEVICE FOR SURGICAL TREATMENT OF THE KNEE
US7726319B1 (en) * 2000-08-24 2010-06-01 Osteotech, Inc. Method for removal of water associated with bone while diminishing the dimensional changes associated with lyophilization
US20070286845A1 (en) * 2000-11-17 2007-12-13 Vascular Biogenics Ltd. Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis
US8071740B2 (en) * 2000-11-17 2011-12-06 Vascular Biogenics Ltd. Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis
AU2003222427B8 (en) 2000-11-17 2010-04-29 Vascular Biogenics Ltd. Promoters exhibiting endothelial cell specificity and methods of using same
US8039261B2 (en) * 2000-11-17 2011-10-18 Vascular Biogenics Ltd. Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis
US20100282634A1 (en) * 2000-11-17 2010-11-11 Dror Harats Promoters Exhibiting Endothelial Cell Specificity and Methods of Using Same for Regulation of Angiogenesis
US6838452B2 (en) 2000-11-24 2005-01-04 Vascular Biogenics Ltd. Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis
US20020114795A1 (en) 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
PL361732A1 (en) * 2000-12-28 2004-10-04 Fidia Advanced Biopolymers S.R.L. Use of a biological material containing three-dimensional scaffolds of hyaluronic acid derivatives for the preparation of implants in arthroscopy and kit for instruments for implanting said biological material by arthroscopy
WO2002060315A2 (en) * 2001-01-30 2002-08-08 Orthogene, Inc. Compositions and methods for the treatment and repair of defects or lesions in articular cartilage using synovial-derived tissue or cells
US6776800B2 (en) * 2001-02-28 2004-08-17 Synthes (U.S.A.) Implants formed with demineralized bone
US20050136038A1 (en) * 2001-10-02 2005-06-23 Isotis N.V. Injectable calcium salt bone filler comprising cells
EP2277887A3 (en) 2001-10-19 2011-02-16 Vascular Biogenics Ltd. Polynucleotide constructs, pharmaceutical compositions and methods for targeted downregulation of angiogenesis and anticancer therapy
MXPA04005940A (en) * 2002-01-22 2004-09-13 Pfizer 3-(imidazolyl)-2-aminopropanoic acids for use as tafi-a inhibitors for the treatment of thrombotic diseases.
AR038680A1 (en) 2002-02-19 2005-01-26 Synthes Ag INTERVERTEBRAL IMPLANT
US20040023322A1 (en) * 2002-08-01 2004-02-05 Goodheart Clyde R. Method of producing non-recombinant BMP-2 and use thereof
US7744651B2 (en) * 2002-09-18 2010-06-29 Warsaw Orthopedic, Inc Compositions and methods for treating intervertebral discs with collagen-based materials
US20040054414A1 (en) 2002-09-18 2004-03-18 Trieu Hai H. Collagen-based materials and methods for augmenting intervertebral discs
US7309361B2 (en) * 2002-10-23 2007-12-18 Wasielewski Ray C Biologic modular tibial and femoral component augments for use with total knee arthroplasty
CN100394989C (en) * 2002-11-15 2008-06-18 华沙整形外科股份有限公司 Collagen-based materials and methods for augmenting intervertebral discs
US20040186471A1 (en) * 2002-12-07 2004-09-23 Sdgi Holdings, Inc. Method and apparatus for intervertebral disc expansion
EP2457541A1 (en) * 2003-02-06 2012-05-30 Synthes GmbH Implant between vertebrae
US7819903B2 (en) 2003-03-31 2010-10-26 Depuy Spine, Inc. Spinal fixation plate
US20050064042A1 (en) * 2003-04-29 2005-03-24 Musculoskeletal Transplant Foundation Cartilage implant plug with fibrin glue and method for implantation
US7067123B2 (en) * 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
US20050222687A1 (en) * 2004-04-02 2005-10-06 Gordana Vunjak-Novakovic Cartilage implant assembly and method for implantation
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
US7488348B2 (en) * 2003-05-16 2009-02-10 Musculoskeletal Transplant Foundation Cartilage allograft plug
US20090291112A1 (en) * 2003-05-16 2009-11-26 Truncale Katherine G Allograft osteochondral plug combined with cartilage particle mixture
US20050013870A1 (en) * 2003-07-17 2005-01-20 Toby Freyman Decellularized extracellular matrix of conditioned body tissues and uses thereof
US7226482B2 (en) 2003-09-02 2007-06-05 Synthes (U.S.A.) Multipiece allograft implant
ES2396689T3 (en) 2003-12-11 2013-02-25 Isto Technologies Inc. Particle Cartilage System
WO2005102281A2 (en) 2004-04-16 2005-11-03 University Of Massachusetts Porous calcium phosphate networks for synthetic bone material
EP3689256A3 (en) 2004-06-23 2020-11-04 Bioprotect Ltd. Device system and method for tissue displacement or separation
US20050288796A1 (en) * 2004-06-23 2005-12-29 Hani Awad Native soft tissue matrix for therapeutic applications
US7837740B2 (en) 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
US20080220044A1 (en) * 2007-03-06 2008-09-11 Semler Eric J Cancellous construct with support ring for repair of osteochondral defects
US7879103B2 (en) 2005-04-15 2011-02-01 Musculoskeletal Transplant Foundation Vertebral disc repair
US7815926B2 (en) 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
US8480757B2 (en) 2005-08-26 2013-07-09 Zimmer, Inc. Implants and methods for repair, replacement and treatment of disease
WO2007030752A2 (en) * 2005-09-09 2007-03-15 University Of Arkansas At Little Rock System and method for tissue generation and bone regeneration
US8936805B2 (en) 2005-09-09 2015-01-20 Board Of Trustees Of The University Of Arkansas Bone regeneration using biodegradable polymeric nanocomposite materials and applications of the same
US9763788B2 (en) 2005-09-09 2017-09-19 Board Of Trustees Of The University Of Arkansas Bone regeneration using biodegradable polymeric nanocomposite materials and applications of the same
US8921109B2 (en) 2005-09-19 2014-12-30 Histogenics Corporation Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof
US20070178137A1 (en) * 2006-02-01 2007-08-02 Toby Freyman Local control of inflammation
US20100305704A1 (en) 2006-02-27 2010-12-02 Synthes Gmbh Intervertebral implant with fixation geometry
US8399619B2 (en) * 2006-06-30 2013-03-19 Warsaw Orthopedic, Inc. Injectable collagen material
US8118779B2 (en) * 2006-06-30 2012-02-21 Warsaw Orthopedic, Inc. Collagen delivery device
EP2076220A2 (en) 2006-07-25 2009-07-08 Musculoskeletal Transplant Foundation Packed demineralized cancellous tissue forms for disc nucleus augmentation, restoration, or replacement and methods of implantation
US8043377B2 (en) 2006-09-02 2011-10-25 Osprey Biomedical, Inc. Implantable intervertebral fusion device
US8852192B2 (en) * 2006-11-13 2014-10-07 Warsaw Orthopedic, Inc. Method and apparatus for osteochondral autograft transplantation
US8163549B2 (en) 2006-12-20 2012-04-24 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
US7718616B2 (en) 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
EP3111869B1 (en) * 2007-03-15 2017-09-20 Ortho-Space Ltd. System of sealing an inflatable prosthesis
WO2008128075A1 (en) 2007-04-12 2008-10-23 Isto Technologies, Inc. Compositions and methods for tissue repair
EP1997457B1 (en) 2007-06-01 2010-11-10 Allergan, Inc. Biological tissue growth support through induced tensile stress
US8540774B2 (en) 2007-11-16 2013-09-24 DePuy Synthes Products, LLC Low profile intervertebral implant
EP2224884A2 (en) * 2007-12-05 2010-09-08 Musculoskeletal Transplant Foundation Cancellous bone implant for cartilage repair
US20090181104A1 (en) * 2007-12-14 2009-07-16 Gino Rigotti Breast reconstruction or augmentation using computer-modeled deposition of processed adipose tissue
WO2009111069A1 (en) * 2008-03-05 2009-09-11 Musculoskeletal Transplant Foundation Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
US9020577B2 (en) * 2008-05-29 2015-04-28 Yale University Systems, devices and methods for cartilage and bone grafting
EP2143451A1 (en) 2008-07-11 2010-01-13 Nobel Biocare Services AG Bone implant application
US9192419B2 (en) 2008-11-07 2015-11-24 DePuy Synthes Products, Inc. Zero-profile interbody spacer and coupled plate assembly
US8469779B1 (en) 2009-01-02 2013-06-25 Lifecell Corporation Method for debristling animal skin
US20100256758A1 (en) * 2009-04-02 2010-10-07 Synvasive Technology, Inc. Monolithic orthopedic implant with an articular finished surface
US8556972B2 (en) * 2009-04-02 2013-10-15 Sevika Holding AG Monolithic orthopedic implant with an articular finished surface
US20110091427A1 (en) * 2009-10-02 2011-04-21 Baxter International Inc. Methods for treating a kidney injury
EP2521586A4 (en) 2010-01-07 2013-06-19 Bioprotect Ltd Controlled tissue dissection systems and methods
US20130116794A1 (en) 2010-08-04 2013-05-09 Shaul Shohat Shoulder implant
US8435305B2 (en) 2010-08-31 2013-05-07 Zimmer, Inc. Osteochondral graft delivery device and uses thereof
US9725689B2 (en) 2010-10-08 2017-08-08 Terumo Bct, Inc. Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
JP2013542837A (en) 2010-11-15 2013-11-28 ジンマー オーソバイオロジクス,インコーポレイティド Bone void filler
EP2654626B1 (en) 2010-12-21 2016-02-24 Synthes GmbH Intervertebral implants and systems
US9241809B2 (en) 2010-12-21 2016-01-26 DePuy Synthes Products, Inc. Intervertebral implants, systems, and methods of use
EP2696908B1 (en) 2011-04-14 2015-03-11 Lifecell Corporation Regenerative materials
US9089523B2 (en) 2011-07-28 2015-07-28 Lifecell Corporation Natural tissue scaffolds as tissue fillers
WO2013057566A2 (en) 2011-10-18 2013-04-25 Ortho-Space Ltd. Prosthetic devices and methods for using same
EP2793964B1 (en) 2011-12-20 2019-03-20 LifeCell Corporation Sheet tissue products
DK3501558T3 (en) 2011-12-20 2021-03-01 Lifecell Corp LIQUID TISSUE PRODUCTS
US9271821B2 (en) 2012-01-24 2016-03-01 Lifecell Corporation Elongated tissue matrices
WO2013126590A2 (en) 2012-02-21 2013-08-29 Baxter International Inc. Pharmaceutical composition comprising cd34+ cells
BR112014026090A8 (en) 2012-04-24 2019-08-27 Lifecell Corp flowable tissue matrix composition
WO2014011402A1 (en) 2012-07-13 2014-01-16 Lifecell Corporation Methods for improved treatment of adipose tissue
AU2013323747B2 (en) 2012-09-26 2017-02-02 Lifecell Corporation Processed adipose tissue
US20140178343A1 (en) 2012-12-21 2014-06-26 Jian Q. Yao Supports and methods for promoting integration of cartilage tissue explants
EP3659633A1 (en) 2013-02-06 2020-06-03 LifeCell Corporation Methods for localized modification of tissue products
CN105992816B (en) 2013-11-16 2018-04-17 泰尔茂比司特公司 Cell amplification in bioreactor
JP6783143B2 (en) 2014-03-25 2020-11-11 テルモ ビーシーティー、インコーポレーテッド Passive replenishment of medium
CN106715676A (en) 2014-09-26 2017-05-24 泰尔茂比司特公司 Scheduled feed
US9867718B2 (en) 2014-10-22 2018-01-16 DePuy Synthes Products, Inc. Intervertebral implants, systems, and methods of use
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
AU2015374114B2 (en) 2014-12-29 2018-07-26 Bioventus, Llc Systems and methods for improved delivery of osteoinductive molecules in bone repair
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
EP3464565A4 (en) 2016-05-25 2020-01-01 Terumo BCT, Inc. Cell expansion
WO2017210109A1 (en) 2016-06-03 2017-12-07 Lifecell Corporation Methods for localized modification of tissue products
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11045583B2 (en) 2016-12-22 2021-06-29 Lifecell Corporation Devices and methods for tissue cryomilling
US10537658B2 (en) 2017-03-28 2020-01-21 DePuy Synthes Products, Inc. Orthopedic implant having a crystalline gallium-containing hydroxyapatite coating and methods for making the same
US10537661B2 (en) 2017-03-28 2020-01-21 DePuy Synthes Products, Inc. Orthopedic implant having a crystalline calcium phosphate coating and methods for making the same
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
JP7393945B2 (en) 2017-03-31 2023-12-07 テルモ ビーシーティー、インコーポレーテッド cell proliferation
US11123375B2 (en) 2017-10-18 2021-09-21 Lifecell Corporation Methods of treating tissue voids following removal of implantable infusion ports using adipose tissue products
US10821205B2 (en) 2017-10-18 2020-11-03 Lifecell Corporation Adipose tissue products and methods of production
EP3697462B1 (en) 2017-10-19 2023-07-12 LifeCell Corporation Flowable acellular tissue matrix products and methods of production
US11246994B2 (en) 2017-10-19 2022-02-15 Lifecell Corporation Methods for introduction of flowable acellular tissue matrix products into a hand
WO2020243497A1 (en) 2019-05-30 2020-12-03 Lifecell Corporation Biologic breast implant

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0034912B1 (en) * 1980-02-21 1983-08-17 J. & P. Coats, Limited Device for use in the treatment of damaged articular surfaces of human joints
JPH0662679B2 (en) * 1985-06-21 1994-08-17 新田ゼラチン株式会社 Tissue-friendly collagen and its manufacturing method
US5543394A (en) 1986-07-01 1996-08-06 Genetics Institute, Inc. Bone morphogenetic protein 5(BMP-5) compositions
US5459047A (en) 1986-07-01 1995-10-17 Genetics Institute, Inc. BMP-6 proteins
US4877864A (en) * 1987-03-26 1989-10-31 Genetics Institute, Inc. Osteoinductive factors
US5013649A (en) 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
IL83003A (en) * 1986-07-01 1995-07-31 Genetics Inst Osteoinductive factors
US5067940A (en) * 1988-03-23 1991-11-26 Life Resonances, Inc. Method and apparatus for controlling the growth of cartilage
US5041138A (en) * 1986-11-20 1991-08-20 Massachusetts Institute Of Technology Neomorphogenesis of cartilage in vivo from cell culture
US4846835A (en) 1987-06-15 1989-07-11 Grande Daniel A Technique for healing lesions in cartilage
US4880429A (en) * 1987-07-20 1989-11-14 Stone Kevin R Prosthetic meniscus
US6020313A (en) * 1987-10-09 2000-02-01 University Of Kansas Method for inducing bone formation using an extract of human osteosarcoma cell line SAOS-2
US5258494A (en) * 1988-04-08 1993-11-02 Stryker Corporation Osteogenic proteins
EP1225225A3 (en) * 1988-04-08 2003-01-08 Stryker Corporation Osteogenic devices
US5266683A (en) * 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US5354557A (en) * 1988-04-08 1994-10-11 Stryker Corporation Osteogenic devices
US5108753A (en) * 1988-04-08 1992-04-28 Creative Biomolecules Osteogenic devices
US5344654A (en) * 1988-04-08 1994-09-06 Stryker Corporation Prosthetic devices having enhanced osteogenic properties
US4975526A (en) * 1989-02-23 1990-12-04 Creative Biomolecules, Inc. Bone collagen matrix for zenogenic implants
US4968590A (en) * 1988-04-08 1990-11-06 Stryker Corporation Osteogenic proteins and polypeptides
US5011691A (en) * 1988-08-15 1991-04-30 Stryker Corporation Osteogenic devices
US5154189A (en) * 1988-06-03 1992-10-13 Oberlander Michael A Method for repairing a torn meniscus
ATE162223T1 (en) 1989-03-28 1998-01-15 Genetics Inst OSTEOINDUCTIVE COMPOSITIONS
US5067962A (en) * 1989-04-18 1991-11-26 Baxter International Inc. Bioprosthetic ligament
US5061286A (en) * 1989-08-18 1991-10-29 Osteotech, Inc. Osteoprosthetic implant
ES2118723T3 (en) * 1989-10-17 1998-10-01 Stryker Corp OSTEOGENIC DEVICES.
US5126323A (en) * 1989-11-16 1992-06-30 Genetics Institute, Inc. Homogeneous purified k-fgf and compositions containing the same
US5067964A (en) * 1989-12-13 1991-11-26 Stryker Corporation Articular surface repair
ATE117959T1 (en) * 1990-02-02 1995-02-15 Johnson & Son Inc S C SEALED BAG WITH TEAR TOP.
US5492697A (en) * 1990-03-05 1996-02-20 Board Of Regents, Univ. Of Texas System Biodegradable implant for fracture nonunions
EP0536186B1 (en) * 1990-05-16 2001-11-21 Genetics Institute, Inc. Bone and cartilage inductive proteins
US5645591A (en) * 1990-05-29 1997-07-08 Stryker Corporation Synthetic bone matrix
US5067963A (en) * 1990-08-21 1991-11-26 Washington University Method of making live autogenous skeletal replacement parts
US5336616A (en) * 1990-09-12 1994-08-09 Lifecell Corporation Method for processing and preserving collagen-based tissues for transplantation
US5206023A (en) * 1991-01-31 1993-04-27 Robert F. Shaw Method and compositions for the treatment and repair of defects or lesions in cartilage
US5208219A (en) * 1991-02-14 1993-05-04 Celtrix Pharmaceuticals Inc. Method for inducing bone growth
US5652118A (en) * 1991-03-11 1997-07-29 Creative Biomolecules, Inc. Nucleic acid encoding a novel morphogenic protein, OP-3
EP0575555B1 (en) 1991-03-11 2001-07-18 Curis, Inc. Protein-induced morphogenesis
DK0592562T3 (en) * 1991-06-25 1999-08-30 Genetics Inst BMP-9 compositions
US5356629A (en) 1991-07-12 1994-10-18 United States Surgical Corporation Composition for effecting bone repair
US5270300A (en) * 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
JP3504263B2 (en) 1991-11-04 2004-03-08 ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー Recombinant bone morphogenetic protein heterodimers, compositions and uses
US5326357A (en) * 1992-03-18 1994-07-05 Mount Sinai Hospital Corporation Reconstituted cartridge tissue
CA2093836A1 (en) * 1992-04-24 1993-10-25 Wayne Gombotz Biodegradable tgf-.beta. delivery system for bone regeneration
US5190547A (en) * 1992-05-15 1993-03-02 Midas Rex Pneumatic Tools, Inc. Replicator for resecting bone to match a pattern
DE69433530T2 (en) * 1993-05-12 2005-01-05 Genetics Institute, LLC, Cambridge BMP-11 COMPOSITIONS
AU677849B2 (en) * 1993-05-12 1997-05-08 Genetics Institute, Llc BMP-10 compositions
US5368051A (en) * 1993-06-30 1994-11-29 Dunn; Allan R. Method of regenerating articular cartilage
US6764994B1 (en) 1993-08-10 2004-07-20 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Growth/differential factor of the TGF-B family
ES2255059T3 (en) * 1993-12-07 2006-06-16 Genetics Institute, Llc BMP-12, BMP-13 AND YOUR INDUCTION COMPOSITIONS OF TENDON.
KR100365573B1 (en) * 1994-03-14 2004-08-25 크라이어라이프, 인크. Transplantation tissue and its manufacturing method
US5906827A (en) * 1994-06-03 1999-05-25 Creative Biomolecules, Inc. Matrix for the manufacture of autogenous replacement body parts
AU4235696A (en) * 1994-11-21 1996-06-17 Wisconsin Alumni Research Foundation 18,19-dinor-vitamin d compounds
ZA963151B (en) * 1995-04-19 1997-04-24 St Jude Medical Matrix substrate for a viable body tissue-derived prosthesis and method for making the same
US5635372A (en) * 1995-05-18 1997-06-03 Genetics Institute, Inc. BMP-15 compositions
AU699918B2 (en) * 1995-06-05 1998-12-17 Genetics Institute, Llc Methods and compositions for healing and repair of connective tissue attachment
US5700774A (en) * 1996-03-26 1997-12-23 Genetics Institute, Inc. Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide, and methods of inducing cartilage by administration of same
EP1370287A2 (en) 2000-12-01 2003-12-17 Wyeth Method and composition for modulating bone growth

Also Published As

Publication number Publication date
AU702220C (en) 2001-10-18
US6027743A (en) 2000-02-22
US20030064090A1 (en) 2003-04-03
AU2691995A (en) 1996-01-04
JPH10504202A (en) 1998-04-28
AU702220B2 (en) 1999-02-18
EP0762903A1 (en) 1997-03-19
US6110482A (en) 2000-08-29
CA2191584C (en) 2002-05-28
JP3504950B2 (en) 2004-03-08
EP0762903B1 (en) 2003-09-17
DE69531779D1 (en) 2003-10-23
US5906827A (en) 1999-05-25
WO1995033502A1 (en) 1995-12-14
DE69531779T2 (en) 2004-07-15
DE69531779T3 (en) 2008-04-30
US20050089544A1 (en) 2005-04-28
EP0762903B2 (en) 2007-08-22
ATE249849T1 (en) 2003-10-15

Similar Documents

Publication Publication Date Title
CA2191584A1 (en) Manufacture of autogenous replacement body parts
AU1831999A (en) Bone augmentation for prosthetic implants and the like
GB2323036B (en) Prosthetic implant and surgical tool
GB2323083B (en) Prosthetic bone material and process for the production of the same
AU3795395A (en) Hard tissue bone cements and substitutes
AU6209394A (en) The use of bisphosphonates in bone surgery
AU5833898A (en) Prosthesis for knee replacement
IL131046A0 (en) Bone reamer for shaping bone sockets or cavities during orthopaedic surgery
GB9705172D0 (en) Evaluating the fit of an orthopaedic implant
AU4513397A (en) Hip joint prosthesis
HUP0103133A3 (en) Implant for repair of animal-cartilage, method for making the implant and cartilaginous tissue
AU9225598A (en) Artificial chordae replacement
AU2475795A (en) Orthopedic prosthesis
AU7726798A (en) Hip replacement
AU9313298A (en) Injectable tissue reconstruction material
AU9113998A (en) Hip prosthesis
AU8145494A (en) Articular prosthesis of the patella and distal femur
GB2323037B (en) Evaluating the fit of an orthopaedic implant
AU3343495A (en) Artificial joint, in particular for replacing the human hip joint
GB9421362D0 (en) Orthopaedic human bone demonstational aid
GB2287654B (en) The use of a shaped composition to increase bone density for use in replacement surgery relating to artificial joints
DE9400690U1 (en) Alloplastic bone replacement, in particular joint endoprosthesis, containing a conical connector
AU9122498A (en) Creating holes in bone via the medullary cavity
GB2315222B (en) Joint for use in total hip replacement
FR2784289B1 (en) BONE JOINT PROSTHESIS IMPLANT

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20150602