CA2191204A1 - Formulation preparation device - Google Patents

Formulation preparation device

Info

Publication number
CA2191204A1
CA2191204A1 CA002191204A CA2191204A CA2191204A1 CA 2191204 A1 CA2191204 A1 CA 2191204A1 CA 002191204 A CA002191204 A CA 002191204A CA 2191204 A CA2191204 A CA 2191204A CA 2191204 A1 CA2191204 A1 CA 2191204A1
Authority
CA
Canada
Prior art keywords
fluids
formulation preparation
spikes
combined
port
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002191204A
Other languages
French (fr)
Other versions
CA2191204C (en
Inventor
Joel Portnoff
Royden M. Coe
John Grimm
Kenneth Raines
Joel Bartholomew
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cephalon Ltd
B Braun Medical Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2191204A1 publication Critical patent/CA2191204A1/en
Application granted granted Critical
Publication of CA2191204C publication Critical patent/CA2191204C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/713—Feed mechanisms comprising breaking packages or parts thereof, e.g. piercing or opening sealing elements between compartments or cartridges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/002—Compounding apparatus specially for enteral or parenteral nutritive solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/45—Mixing liquids with liquids; Emulsifying using flow mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/50—Movable or transportable mixing devices or plants
    • B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
    • B01F33/5011—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/716—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components
    • B01F35/7164—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components the containers being placed in parallel before contacting the contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/71805—Feed mechanisms characterised by the means for feeding the components to the mixer using valves, gates, orifices or openings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Abstract

A formulation preparation device is provided herein which contains a valve assembly, transfer spikes, syringe port and tube, these components being interconnected so as to provide for controlled fluid flow between the spikes and port, through the assembly, in specific directions only. The device has an enclosed, sterilizable, grippable housing and can be used to mix combine fluids in reproducible and predetermined proportions. Combination is accomplished aseptically, avoiding contact between the device's operator and the fluids and the substances combined. Biologically active compounds can be combined with one or more fluids, including such aqueous liposome suspensions, using the device. A formulation preparation kit containing, in addition to the device, the fluids and compounds to be formulated is thus also provided herein; methods of using the device to prepare such formulations are further provided herein.
CA002191204A 1994-05-23 1995-05-23 Formulation preparation device Expired - Fee Related CA2191204C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24807594A 1994-05-23 1994-05-23
US08/248,075 1994-05-23
PCT/US1995/006480 WO1995031955A2 (en) 1994-05-23 1995-05-23 Formulation preparation device

Publications (2)

Publication Number Publication Date
CA2191204A1 true CA2191204A1 (en) 1995-11-30
CA2191204C CA2191204C (en) 2004-04-20

Family

ID=22937571

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002191204A Expired - Fee Related CA2191204C (en) 1994-05-23 1995-05-23 Formulation preparation device

Country Status (12)

Country Link
US (1) US5583052A (en)
EP (1) EP0760644B1 (en)
JP (1) JP4221515B2 (en)
KR (1) KR970703123A (en)
AT (1) ATE168554T1 (en)
AU (1) AU681036B2 (en)
CA (1) CA2191204C (en)
DE (1) DE69503629T2 (en)
DK (1) DK0760644T3 (en)
ES (1) ES2119446T3 (en)
IL (1) IL113832A (en)
WO (1) WO1995031955A2 (en)

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BR112015027555B1 (en) 2013-05-10 2022-02-01 Medimop Medical Projects Ltd Medical device for use with a needleless syringe, a vial and a liquid carrier to fill the needleless syringe with an injection solution for injection into a patient
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JP6747650B2 (en) 2014-12-24 2020-08-26 フェロサン メディカル デバイシーズ エイ／エス Syringe for holding and mixing the first substance and the second substance
WO2016110838A1 (en) 2015-01-05 2016-07-14 Medimop Medical Projects Ltd Dual vial adapter assemblages with quick release drug vial adapter for ensuring correct usage
US10918796B2 (en) 2015-07-03 2021-02-16 Ferrosan Medical Devices A/S Syringe for mixing two components and for retaining a vacuum in a storage condition
US10357429B2 (en) 2015-07-16 2019-07-23 West Pharma. Services IL, Ltd. Liquid drug transfer devices for secure telescopic snap fit on injection vials
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CN108366905A (en) 2015-11-25 2018-08-03 西部制药服务以色列有限公司 Include double bottle commutator components of the vial adapter of the inlet valve with automatic-sealed
IL245800A0 (en) 2016-05-24 2016-08-31 West Pharma Services Il Ltd Dual vial adapter assemblages including identical twin vial adapters
IL245803A0 (en) 2016-05-24 2016-08-31 West Pharma Services Il Ltd Dual vial adapter assemblages including vented drug vial adapter and vented liquid vial adapter
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Also Published As

Publication number Publication date
IL113832A0 (en) 1995-08-31
AU2600895A (en) 1995-12-18
JPH10500597A (en) 1998-01-20
AU681036B2 (en) 1997-08-14
WO1995031955A2 (en) 1995-11-30
KR970703123A (en) 1997-07-03
EP0760644B1 (en) 1998-07-22
IL113832A (en) 1999-11-30
ATE168554T1 (en) 1998-08-15
ES2119446T3 (en) 1998-10-01
WO1995031955A3 (en) 1996-01-11
DK0760644T3 (en) 1998-12-14
EP0760644A1 (en) 1997-03-12
US5583052A (en) 1996-12-10
DE69503629T2 (en) 1998-11-26
DE69503629D1 (en) 1998-08-27
CA2191204C (en) 2004-04-20
JP4221515B2 (en) 2009-02-12

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Effective date: 20120523