CA2182803A1 - Pre-filled syringe with lugs - Google Patents
Pre-filled syringe with lugsInfo
- Publication number
- CA2182803A1 CA2182803A1 CA002182803A CA2182803A CA2182803A1 CA 2182803 A1 CA2182803 A1 CA 2182803A1 CA 002182803 A CA002182803 A CA 002182803A CA 2182803 A CA2182803 A CA 2182803A CA 2182803 A1 CA2182803 A1 CA 2182803A1
- Authority
- CA
- Canada
- Prior art keywords
- lug
- syringe
- barrel
- plastic syringe
- distal surface
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
- A61M5/14546—Front-loading type injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
- A61M5/14566—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir for receiving a piston rod of the pump
Abstract
A plastic syringe for use with power injector systems comprises a cylindrical barrel with an axially reciprocable plunger within the barrel and a discharge extension at the distal end of the barrel terminating in a discharge outlet. At least one radially outwardly extending mounting lug is located at or near the outer proximal end of the barrel, and has a distal surface having first and second ends. The lug is shaped such that the center of the distal surface of the lug is distally offset from the ends of the lug. In another embodiment, the syringe comprises a cylindrical collar adapted to fit over and attach to the proximal end of the cylindrical barrel, and the lug is located at or near the outer proximal end of the collar. The syringe may contain a diagnostic imaging contrast agent. Preferably the lugs are provided opposite each other.
Description
WO 95/26211 l- ~ F~~ 5~ 5 PRE-FILLEI) SYRINGE WITH LUGS
This invention relates to a plastic syringe, particularly for use with a power injector.
- The use of contrast media for image rnhAnr, t in medical diagnostic imaging is widespread For example, x-ray contrast agents, which are typically ig~l1ni~t~1 contrast agents, such as the nonionic contrast agent iohexol, have gained widespread commercial acceptance in various x-ray imaging procedures such as x-ray computed tomography ( CT) .
To effect intrntll~rtinn of contrast media into body cavities such as the vascular networkr it has been common practiee to utilize inj ector syringes in combination with catheters. The syringe can be mounted in a power inj eetor apparatus, with the distal end of the syringe being connected to the catheter whieh is introduced into the system to be studied. It has been estimated recently that of the apprn~ir~tf~ly g million contrast ,-nh~nr-~-l CT scans performed in the United States each year, about one-half involve power injectors and the number is growing. Additionally, apprn~ir-tf~ly gO96 of the 1. 3 million cardiac angiographic procedures which take place annually in the United States involve power inj ectors .
The use of prefilled syringes, ~ i . e ., syringes prefilled with a unit dose, e.g., of contrast media, 3 o with such power inj ectors provides greater convenience and safety to the health care worker while minimi7ing waste. For example, the need to transfer contrast media from glass rnnt~in~rS to empty syringes can be entirely eliminated Additionally, risks of rnnt~min~tion associated with preparing sterile contrast agent for inj ection into the patient can be reduced .
Power inj ectors f or various CT procedures such as SUBSTITUTE SHEET (RULE 263 WO95/26211 %~ a~ 5 -angiography are described, e . g ., in U. S . Patent No .
4,006,736; U.S. Patent No. 4,677,980; U.S. Patent No.
4,854,324; U.S. Patent No. 4,911,695; and U.S. Patent No. 5,007,904. The power injectors described in these 5 patents are of the rear-loading type, i.e., syringes are rear-loaded into a pressure jacket of the injector.
More specifically, these injectors comprise a rotatable turret which carries a pair of the pressure j ackets and which is rotatable so that when one of the pLt:Sl:lUL~
10 jackets into which a syringe has been rear-loaded is in an injection position, the other pressure jacket is in a position in which a syringe can be rear-loaded.
Subsequently, when injection of liquid from the first syringe is completed, the ~turret is rotated to move the 15 ~irst syringe to an l1nln~rl;ng position. When the pressure j acket and its associated syringe has been located in the injection position, a drive member of the inj ector is moved f orward to become drivingly engaged with a plunger in the syringe.
European Patent Application No. 584,531 describes a front-loading medical injector wherein a syringe is mountable upon and removable from a front wall of an inj ector housing or mounting plate . The f ront- loading injector ;nrlll~lP~ a readily releasable m.~rh~ni~m for supporting the syringe on the front wall of an injector housing for an injection operation. The releasable mechanism; nrl l~ S at least one retaining portion on the mounting m~rh;lni ~-m releasably engageable with a mating retaining portion on the syringe. In addition to 30 enhanced setup convenience, such a ~ront-loading inj ector provides additional advantages to the health care worker. By not being enclosed in a pressure j acket, the health care worker is better able to view the status of the syringe visually during an inj ection 35 operation. By allowing the health care worker to better see the syringe, the worker can readily ~s~r~rm,n~
whether the syringe is empty or full, the amount of .
2182~03 ~ .
contrast medium delivered, the presence or absence of bubbles, etc.
Heretofore, pLastic syringes have been provided for such front-loading power injectors. One such syringe comprises a set of radially ~ Pn~i ng lugs spaced 180 degrees apart which engage two mating slots in a mounting plate on the power inj ector by inserting the syringe lugs into the slots and rotating the syringe 90 degrees. This design has achieved some success with a syringe fabricated of polyethylene terPrhth~lAte (PET) .
However, this and other designs proposed in European Patent Application No. 584, 531 are less than adeguate for some plastics, particularly those of low modulus and/or yield strength, due to the fact that stresses generated during inj ection can cause localized and/or complete shearing of the lug of f the barrel .
Furthermore, PET, when autoclaved at 210F ~'11( ), undergoes a phase transition from a clear amorphous state to an opaque crystalline state. This is undesirable because one of the dangers associated with the injection of fluids into a patient is at the risk that air will be ~rri~lpntAl ly injected into the patient.
The presence of a transparent syringe barrel enables the health care worker to readily detect empty and/or partially filled syringes prior to an attempted inj ection . Thus, it would be highly desirable to be able to replace PET in a plastic syringe for use with power inj ectors with other plastic materials which can be autoclaved without ~ ing clarity.
3 0 In accordance with a f irst aspect of t~e invention there is provided a plastic syringe comprising a cylindrical barrel for receiving a liquid, a plunger axially reciprocable within the barrel for discharging the liquid therefrom, a discharge extension at the distal end of the barrel terminating in a discharge outlet, at least one radially outwardly extending mounting lug located at or near the outer proximal end AMENDED S~IEET
... .. . . .. . . ... . _, . . , _ _ _ _ _ _ .
wo 9S/26211 ~18 2 8 0 3 r~ . /17 of the barrel, the lug having a distal surface having first and second ends and being shaped such that the center of the distal surface of the lug is distally of f set f rom the ends of the lug .
~rrnr~;nj to a second aspect of the iLvention there is provided a plastic syringe inrlll~l;ng a barrel, plunger aLd discharge extension as described above, a cylindrical collar adapted to fit over and attach to the proximal end of ~the barrel, and at least one Tnmlnt;ng lug as described above located at or near the outer proximal end of the collar.
We have discovered that localized stresses generated in the lug of a prefilled plastic syringe during injection with a power injector can be unexpectedly reduced and more evenly distributed by such shaping of the distal surface of the lug. Surprisingly, stress reduction of over 50Y6 can be achieved in preferred r-l~Q~; s. This enables prefilled syringes f or use in f ront - loading power inj ectors to be fabricated of various plastics, ;nrl~tl;ng lower strength plastics such as a methylpentane copolymer and polypropylene, which have good clarity even af ter autoclaving .
According to a further aspect of the invention, there is provided a power inj ector system cQmprising a mounting plate adapted to receive a syringe, a driving morll~n; Sm ;nrlllr7;ng head and shaft Pl~ t~, and a plastic syringe as described above mounted on the plate, wherein the plunger of the syringe selectively engages with the head and shaft ~ m~nt~ of the driving mechanism .
In a preferred embodiment, the syringe comprises two t;nrj lugs spaced 180 degrees apart with respect to the barrel.
Certain preferred Pmhn~l;mon~:c of the invention will now be described by way of example only and with reference to the Arrrn~?~nying drawings, in which:-J~
~ 1 ~2 803 lo ~
WO95~26211 . ~,,~.~ /l5 Fig. 1 is a partial isometric view of a plastic syringe and power inj ector of this inve~tion showing an injector housing featuring a mounting plzte and a syringe in disassem.bled rol;tinnch;r;
Fig. Z is a cross-sectional view of a preferred i ' ofl;mont of a plastic syringe ;lrrnrfl;n~ to this invention, without an associated plunger;
Fig. 3 is a partial cross-sectional view illustrating an injector housing featuring a t;n~
plate and a syringe in assem.bled relationship;
Fig. 4 is a partial top plan view of a syringe of this invention illustrating a crowned mounting lug featuring reinforcing ribs and having a crown thickness represented by X;
Fig. 5 is an end view, as seen along the line 5-5 in Fig. 2, illustrating an embodiment of a syringe of this invention having a pair of crowned mounting lugs f eaturing reinf orcing ribs;
Fig. 6 is an end view, as seen along the line 6-6 20 in Fig. 2, also illustrating the pair of crowned ~mlnt; n~ lugs; and Fig. 7 is a cross-sectional view of an alternative omhorl;m^nt of a syringe of this invention featuring a collar.
The invention is hereinafter described in reference to preferred em.bodiments featuring a prefilled autoclavable plastic syringe for use with a front-loading power injector. However, the invention is believed to be applicable to any syringe designed for high injection pressures and featuring mounting lugs with unconstrained barrel sections between the lugs.
The syringe of this invention is particularly useful in conjunction with a front-loading power injector such as is depicted in Fig. 1. Front-loading injector apparatus 10 utilizes syringe 12 capable of being front-loaded onto mounting plate 14 on front wall 16 of housing 18 of injector 20. The mounting plate on 2 1 8 7 8 0 3 P~l, ., . Jl9 ,, I
the front wall of the housing is provided with an PREPnt;~lly cylindrical openiny 22 for receiving the proximal end of the syringe. The opening inrl~lflP~ at least one, and more preferably, a pair of upper and 5 lower slots 24 through which mounting lugs 26 of the syringe may pass as the proximal end of the syringe is inserted into the opening. The mmlnt; n~ assembly further ;nrlll-lP~ opposed retaining flanges 28 on opposite sides thereof so that af ter the proximal end of lO the syringe has been inserted into the opening, and the syringe is rotated clockwise, the mounting lugs on the syringe become engaged behind the rrt~;n;ng flanges to secure the syringe to the housing f ront wall . During mmlnt;ng, the rotation of the syringe can be limited by 15 suitable rearwardly projecting stops 30 at adjacent ends of the retaining flanges in the mounting plate. The t;nrJ plate can also include inner annular ring 32 in spaced relat;nn~h;p to the retaining flanges to provide support for the proximal end of the syringe and define 20 semi-annular guide slots 34 for receiving the mmlnt;
lugs .
The syringe of this invention comprises a generally cylindrical barrel 36 Pnrlos;ng an interior volume for receiving a liquid. Plunger 38 is axially reciprocable 25 within the barrel and is slidably mounted, in engagement, with the inner wall surface of the cylindrical barrel. At its distal end, the barrel has discharge extension 40 tPrm;n~t;ng in tubular discharge outlet 42. In preferred: oriimpnt~ the barrel is 30 joined via frustoconical section 44 to distal tapered section 46 which in turn is joined to the tubular discharge outlet. The tapered section of the syringe optionally features, on a portion of its exterior surface, thread 48 (~ig. 2) which can be employed for 35 rmlnl ;nr, the syringe, via a complementary threaded connected fitting, to a catheter or the like (not shown) . The syringe can be provided with one or more WO95/26211 2182g03 ~ .,5~ /15 guide P7~tPn~ n~ 47 and/or alignment edge 4g to f acilitate assemblage of the syringe with various power inj ector designs .
The plunger is slidably positioned within the cylindrical barrel for discharging the liquid from the barrel through the discharge outlet. The plunger can be connectable to driving member 5 0 in the inj ector housing, preferably by a readily rPlp~RAhlp mechanism formed in part by the plunger comprising base member 52 having hook members 54 or the like P~tPntl; n~ rearwardly therefrom. Portions 56 of these members extend radially inward in opposed relationship. The hook members are designed to facilitate axial movement of the plunger in either direction when c~-nnPrtP~l to the driving mem.ber by the rPl ~ hl P mPt~h~n; qm, An actuating mechanism can cause the drive member to reciprocate the plunger in the syringe body. The drive member comprises base portion 60 (Fig. 3), stem 62 and rectangular head 64 extending radially from the stem. The syringe can be provided with sealing ring 66 which engages outer annular rir,g 68 when the syringe is inserted into the opening in the mounting plate.
In a preferred Pmho~ , the plunger can comprise a body and a sheath such as is described in U . S . Patent No. 5, 007, 904 . The plunger body can be fabricated of any suitable material of construction which is advantageously employed in the use enviL~ ~ with which the syringe is associated. The plunger body may be f ormed of a generally stif f, resilient material such as a hard elastomer or alternatively it may be formed of any other suitable natural or synthetic, polymeric or nonpolymeric material. In practice, plastics are generally preferred. Preferred materials include polycarbonate and polyphenylene oxide, such as the polyphenylene oxide material commercially available from General Electric Company under the trademark Valox~.
The sheath portion of the plunger, which slidably WO95/26211 231~3~8n3 r_l _. /19 ~
rnnt~rtS the inner w~all of ~the cylindrical barrel, can be f ormed of any suitable material which is advAntAgPnu~ly employed in the envil~ t~ with which the plunger is associated Preferred materials of construction include rubber materials, with natural rubber being pref erred .
The syringe of this invention; nrl lmlPA at least one radially outwardly extending mrllntin~ lug 26 located at or near the outer proximal end of the barrel. The ~ .nting lug has distal surface 70 (Fig. 4~ having first end 72 and second end 74 which def ine a constrained portion of the barrel. The lugs can be provided with reinforcing ribs 76. The lug has a crown shape, i.e., the center of the distal surface o~ the lug is distally offset from the ends of the lug. The distal surface of the lug preferably is ArrllAtPly shaped. In a preferred pmhQ~limPnt, as illustrated best in Figs. 5 and 6, the syringe comprises a pair of mrllnting lugs spaced~180 degrees apart with respect to the barrel.
The lug can comprise a generally solid crowned shoulder, as ~Pr; rtP~l in Fig. 1, a reinforced ribbed design, such as is depicted in Figs. 2, 4, 5 and 6, or any other shape which provides the advantages described herein .
The preferred thickness X of the=crown, i.e., the amount by which the center of the distal surface of the lug is distally offset frQm the ends of the lug (see Fig. 5), is detPrminp~l primarily by the modulus and yield strength of the plastic, injection rressures and syringe wall tll;rknPAs. In preferred ' rt1ir ~, the crown thickness is at least about 0 . 025 cm ( 0 . 01 inch) and more preferably, at least about 0.060 cm (0.025 inch). For a syringe described above, a crown thickness of 0.075 cm (0.030 inch) is most preferred for injection pressures of 300-400 PSI (21.1-28.1 kg/cm2). ~Iigher pressures would require more crown while lower pressures would re~uire less.
WO 95/26211 ~ 1 8 2 ~ 0 3 P~ g _ g While Applicants do not wish to be bound by theoretical -hAn;qmq, ~ c~;nn plots from extensive finite element analyses suggest that unconstrained portions of the syringe , e . g ., portions between the 5 lugs, during inj ection are pulled f orward by inj ection forces, causing the lugs to curl and forcing the front edges of the lugs into the mmlnt;ng plate, thus rnnr~nt~ating stresses at the end points of the lugs.
The crowned lug design of this invention permits the lO center of the lug to contact the ~;ng plate firæt during high pressure injections. The natural deflection of the syringe under such high injection pressures f lattens the lug and distributes the f orces over a larger surface area, thus reducing the overall stress in 15 the lugs.
In another - -';m~nt depicted in Fig. 7, the syringe ;nrlil~lP,q cylindrical collar 90 adapted to fit over and attach to the proximal end of the cylindrical barrel. The collar can be attached to the barrel by 20 conv~n~innAl means, e.g., by a snap ~it or by threading engagement. The collar has at least one radially outwardly ,~ n~;nj mounting lug located at or near the outer proximal end of the collar. The lug has a distal surface having first and second ends defining a 25 constrained portion of the collar, which lug is crown shaped, such that the center of the distal surface of the lug is distally offse~ from the ends of the lug, as defined above. This "two-piece" design provides several advantages. First, the mating collar can be fabricated 30 of a different, e.g., higher modulus, plastic than the barrel inasmuch as it can be assem.bled onto the barrel - after the autoclave cycle. Second, any changes to the injector mounting plate which interfaces with the syringe could be ~cc -'-ted by changing only the 35 collar, and conse~uently would not nPr~qs-~ily affect that portion of the pref illed syringe subj ect to re~ulatory approval. In other words, any design changes WO 9~/262~ liS
to the exterior of a one-piece syringe could require recertification of the entire prefilled package. Third, this "two-piece" design featuring a collar can be easily and readily adapted to various power inj ectors merely by 5 designing a separate collar for each type of injector/syringe t;ng interface.
A power injector for use with the syringe described ahove comprises a tin~ plate adapted to receive a syringe as de6cribed above, and a driving member 10 ;nr~ head and shaft Pl R, The head and shaft Pl' ' R of the driving member can selectively engage the plunger of the syringe by any of a variety of conV~nt; nn;~l technigues well known in the art .
As noted, it is an advantageous feature that this 15 invention enables pref illed syringes f or use in f ront -loading power injectors to be fAhr; r~ted of lower modulus plastics such as a methylpentene copolymer and polypropylene. However, the syringe according to this invention can be fabricated of any suitable plastic such 20 as polyr~rhrm~tP~ polysulfone, polyethylene terPrhth~ te, amorphous polyolefir~, polypropylene, polyphenylene oxide, methylpentene copolymer and the like. A preferred plastic is a methylpentene copolymer available from Mitsui PetrochemiCal Industries, Ltd., 25 New York, NY, under the tr~lPn~ TPX RT18; having the structural formula ~ CH2 - C~z ~ n CHz CH~ CH3 ) 2 In any event, the use of this invention in conjunction with higher modulus plastics, such as PET, results in improved overall reliability and facilitates high injection forces. Additionally, the crowned lug design 35 of this invention enables the lug to be fabricated from less material, thus saving material costs.
The syringe of thi s invention can be used in ~182803 WO 95/26211 ~ S
conjunction with any liquid Pre~erred liquids include therapeutic and/or diagnostic agents. In particularly preferred Pmhnr1;r^ntc, the liquid is a diagnostic imaging contrast media comprising a diagnostic imaging 5 contrast agent. In the most preferred embodiments, the li~id is an x-ray contrast media featuring an x-ray contrast agent. A particularly preferred x-ray contrast agent is iohexol. Other contrast media for x-ray imaging which are in commercial or rlin;l-~l use include 10 i~-fli~ n~l, metri7~mlflP, ;~rs~m;~ ioversol, iotrolan, iopromide, ioxalan, hexabrix (i~ g~tP --3ll lm;n P and ioxaglate sodium), iothalamate meglumine, iothalamate sodium, diatrizoate meglumine and diatrisoate sodium.
The invention is also useful in conjunction with plastic 15 syringes filled with liquid contrast media for ultrasound imaging and magnetic resonance imaging procedures .
It will be seen that the invention provides a syringe which can be fabricated of low strength, 20 autoclavable plastics such as a methyl rPntPnP copolymer or polypropylene and used in conjunction with commercially available power inj ectors; which can be prefilled with the contrast media iohexol and used in conjunction with commercially available power injectors;
25 and which more uni~ormly distributes injection pressure across the lug face, thus improving the load bearing ef f iciency of the mounting lugs and providing improved overall reliability.
The invention has been described in detail with 30 particular rPfPrPnt P to certain preferred Pmhof~;mpnts thereof, but it will be understood that variations and modifications can be e~fected within the scope of t~e invention
This invention relates to a plastic syringe, particularly for use with a power injector.
- The use of contrast media for image rnhAnr, t in medical diagnostic imaging is widespread For example, x-ray contrast agents, which are typically ig~l1ni~t~1 contrast agents, such as the nonionic contrast agent iohexol, have gained widespread commercial acceptance in various x-ray imaging procedures such as x-ray computed tomography ( CT) .
To effect intrntll~rtinn of contrast media into body cavities such as the vascular networkr it has been common practiee to utilize inj ector syringes in combination with catheters. The syringe can be mounted in a power inj eetor apparatus, with the distal end of the syringe being connected to the catheter whieh is introduced into the system to be studied. It has been estimated recently that of the apprn~ir~tf~ly g million contrast ,-nh~nr-~-l CT scans performed in the United States each year, about one-half involve power injectors and the number is growing. Additionally, apprn~ir-tf~ly gO96 of the 1. 3 million cardiac angiographic procedures which take place annually in the United States involve power inj ectors .
The use of prefilled syringes, ~ i . e ., syringes prefilled with a unit dose, e.g., of contrast media, 3 o with such power inj ectors provides greater convenience and safety to the health care worker while minimi7ing waste. For example, the need to transfer contrast media from glass rnnt~in~rS to empty syringes can be entirely eliminated Additionally, risks of rnnt~min~tion associated with preparing sterile contrast agent for inj ection into the patient can be reduced .
Power inj ectors f or various CT procedures such as SUBSTITUTE SHEET (RULE 263 WO95/26211 %~ a~ 5 -angiography are described, e . g ., in U. S . Patent No .
4,006,736; U.S. Patent No. 4,677,980; U.S. Patent No.
4,854,324; U.S. Patent No. 4,911,695; and U.S. Patent No. 5,007,904. The power injectors described in these 5 patents are of the rear-loading type, i.e., syringes are rear-loaded into a pressure jacket of the injector.
More specifically, these injectors comprise a rotatable turret which carries a pair of the pressure j ackets and which is rotatable so that when one of the pLt:Sl:lUL~
10 jackets into which a syringe has been rear-loaded is in an injection position, the other pressure jacket is in a position in which a syringe can be rear-loaded.
Subsequently, when injection of liquid from the first syringe is completed, the ~turret is rotated to move the 15 ~irst syringe to an l1nln~rl;ng position. When the pressure j acket and its associated syringe has been located in the injection position, a drive member of the inj ector is moved f orward to become drivingly engaged with a plunger in the syringe.
European Patent Application No. 584,531 describes a front-loading medical injector wherein a syringe is mountable upon and removable from a front wall of an inj ector housing or mounting plate . The f ront- loading injector ;nrlll~lP~ a readily releasable m.~rh~ni~m for supporting the syringe on the front wall of an injector housing for an injection operation. The releasable mechanism; nrl l~ S at least one retaining portion on the mounting m~rh;lni ~-m releasably engageable with a mating retaining portion on the syringe. In addition to 30 enhanced setup convenience, such a ~ront-loading inj ector provides additional advantages to the health care worker. By not being enclosed in a pressure j acket, the health care worker is better able to view the status of the syringe visually during an inj ection 35 operation. By allowing the health care worker to better see the syringe, the worker can readily ~s~r~rm,n~
whether the syringe is empty or full, the amount of .
2182~03 ~ .
contrast medium delivered, the presence or absence of bubbles, etc.
Heretofore, pLastic syringes have been provided for such front-loading power injectors. One such syringe comprises a set of radially ~ Pn~i ng lugs spaced 180 degrees apart which engage two mating slots in a mounting plate on the power inj ector by inserting the syringe lugs into the slots and rotating the syringe 90 degrees. This design has achieved some success with a syringe fabricated of polyethylene terPrhth~lAte (PET) .
However, this and other designs proposed in European Patent Application No. 584, 531 are less than adeguate for some plastics, particularly those of low modulus and/or yield strength, due to the fact that stresses generated during inj ection can cause localized and/or complete shearing of the lug of f the barrel .
Furthermore, PET, when autoclaved at 210F ~'11( ), undergoes a phase transition from a clear amorphous state to an opaque crystalline state. This is undesirable because one of the dangers associated with the injection of fluids into a patient is at the risk that air will be ~rri~lpntAl ly injected into the patient.
The presence of a transparent syringe barrel enables the health care worker to readily detect empty and/or partially filled syringes prior to an attempted inj ection . Thus, it would be highly desirable to be able to replace PET in a plastic syringe for use with power inj ectors with other plastic materials which can be autoclaved without ~ ing clarity.
3 0 In accordance with a f irst aspect of t~e invention there is provided a plastic syringe comprising a cylindrical barrel for receiving a liquid, a plunger axially reciprocable within the barrel for discharging the liquid therefrom, a discharge extension at the distal end of the barrel terminating in a discharge outlet, at least one radially outwardly extending mounting lug located at or near the outer proximal end AMENDED S~IEET
... .. . . .. . . ... . _, . . , _ _ _ _ _ _ .
wo 9S/26211 ~18 2 8 0 3 r~ . /17 of the barrel, the lug having a distal surface having first and second ends and being shaped such that the center of the distal surface of the lug is distally of f set f rom the ends of the lug .
~rrnr~;nj to a second aspect of the iLvention there is provided a plastic syringe inrlll~l;ng a barrel, plunger aLd discharge extension as described above, a cylindrical collar adapted to fit over and attach to the proximal end of ~the barrel, and at least one Tnmlnt;ng lug as described above located at or near the outer proximal end of the collar.
We have discovered that localized stresses generated in the lug of a prefilled plastic syringe during injection with a power injector can be unexpectedly reduced and more evenly distributed by such shaping of the distal surface of the lug. Surprisingly, stress reduction of over 50Y6 can be achieved in preferred r-l~Q~; s. This enables prefilled syringes f or use in f ront - loading power inj ectors to be fabricated of various plastics, ;nrl~tl;ng lower strength plastics such as a methylpentane copolymer and polypropylene, which have good clarity even af ter autoclaving .
According to a further aspect of the invention, there is provided a power inj ector system cQmprising a mounting plate adapted to receive a syringe, a driving morll~n; Sm ;nrlllr7;ng head and shaft Pl~ t~, and a plastic syringe as described above mounted on the plate, wherein the plunger of the syringe selectively engages with the head and shaft ~ m~nt~ of the driving mechanism .
In a preferred embodiment, the syringe comprises two t;nrj lugs spaced 180 degrees apart with respect to the barrel.
Certain preferred Pmhn~l;mon~:c of the invention will now be described by way of example only and with reference to the Arrrn~?~nying drawings, in which:-J~
~ 1 ~2 803 lo ~
WO95~26211 . ~,,~.~ /l5 Fig. 1 is a partial isometric view of a plastic syringe and power inj ector of this inve~tion showing an injector housing featuring a mounting plzte and a syringe in disassem.bled rol;tinnch;r;
Fig. Z is a cross-sectional view of a preferred i ' ofl;mont of a plastic syringe ;lrrnrfl;n~ to this invention, without an associated plunger;
Fig. 3 is a partial cross-sectional view illustrating an injector housing featuring a t;n~
plate and a syringe in assem.bled relationship;
Fig. 4 is a partial top plan view of a syringe of this invention illustrating a crowned mounting lug featuring reinforcing ribs and having a crown thickness represented by X;
Fig. 5 is an end view, as seen along the line 5-5 in Fig. 2, illustrating an embodiment of a syringe of this invention having a pair of crowned mounting lugs f eaturing reinf orcing ribs;
Fig. 6 is an end view, as seen along the line 6-6 20 in Fig. 2, also illustrating the pair of crowned ~mlnt; n~ lugs; and Fig. 7 is a cross-sectional view of an alternative omhorl;m^nt of a syringe of this invention featuring a collar.
The invention is hereinafter described in reference to preferred em.bodiments featuring a prefilled autoclavable plastic syringe for use with a front-loading power injector. However, the invention is believed to be applicable to any syringe designed for high injection pressures and featuring mounting lugs with unconstrained barrel sections between the lugs.
The syringe of this invention is particularly useful in conjunction with a front-loading power injector such as is depicted in Fig. 1. Front-loading injector apparatus 10 utilizes syringe 12 capable of being front-loaded onto mounting plate 14 on front wall 16 of housing 18 of injector 20. The mounting plate on 2 1 8 7 8 0 3 P~l, ., . Jl9 ,, I
the front wall of the housing is provided with an PREPnt;~lly cylindrical openiny 22 for receiving the proximal end of the syringe. The opening inrl~lflP~ at least one, and more preferably, a pair of upper and 5 lower slots 24 through which mounting lugs 26 of the syringe may pass as the proximal end of the syringe is inserted into the opening. The mmlnt; n~ assembly further ;nrlll-lP~ opposed retaining flanges 28 on opposite sides thereof so that af ter the proximal end of lO the syringe has been inserted into the opening, and the syringe is rotated clockwise, the mounting lugs on the syringe become engaged behind the rrt~;n;ng flanges to secure the syringe to the housing f ront wall . During mmlnt;ng, the rotation of the syringe can be limited by 15 suitable rearwardly projecting stops 30 at adjacent ends of the retaining flanges in the mounting plate. The t;nrJ plate can also include inner annular ring 32 in spaced relat;nn~h;p to the retaining flanges to provide support for the proximal end of the syringe and define 20 semi-annular guide slots 34 for receiving the mmlnt;
lugs .
The syringe of this invention comprises a generally cylindrical barrel 36 Pnrlos;ng an interior volume for receiving a liquid. Plunger 38 is axially reciprocable 25 within the barrel and is slidably mounted, in engagement, with the inner wall surface of the cylindrical barrel. At its distal end, the barrel has discharge extension 40 tPrm;n~t;ng in tubular discharge outlet 42. In preferred: oriimpnt~ the barrel is 30 joined via frustoconical section 44 to distal tapered section 46 which in turn is joined to the tubular discharge outlet. The tapered section of the syringe optionally features, on a portion of its exterior surface, thread 48 (~ig. 2) which can be employed for 35 rmlnl ;nr, the syringe, via a complementary threaded connected fitting, to a catheter or the like (not shown) . The syringe can be provided with one or more WO95/26211 2182g03 ~ .,5~ /15 guide P7~tPn~ n~ 47 and/or alignment edge 4g to f acilitate assemblage of the syringe with various power inj ector designs .
The plunger is slidably positioned within the cylindrical barrel for discharging the liquid from the barrel through the discharge outlet. The plunger can be connectable to driving member 5 0 in the inj ector housing, preferably by a readily rPlp~RAhlp mechanism formed in part by the plunger comprising base member 52 having hook members 54 or the like P~tPntl; n~ rearwardly therefrom. Portions 56 of these members extend radially inward in opposed relationship. The hook members are designed to facilitate axial movement of the plunger in either direction when c~-nnPrtP~l to the driving mem.ber by the rPl ~ hl P mPt~h~n; qm, An actuating mechanism can cause the drive member to reciprocate the plunger in the syringe body. The drive member comprises base portion 60 (Fig. 3), stem 62 and rectangular head 64 extending radially from the stem. The syringe can be provided with sealing ring 66 which engages outer annular rir,g 68 when the syringe is inserted into the opening in the mounting plate.
In a preferred Pmho~ , the plunger can comprise a body and a sheath such as is described in U . S . Patent No. 5, 007, 904 . The plunger body can be fabricated of any suitable material of construction which is advantageously employed in the use enviL~ ~ with which the syringe is associated. The plunger body may be f ormed of a generally stif f, resilient material such as a hard elastomer or alternatively it may be formed of any other suitable natural or synthetic, polymeric or nonpolymeric material. In practice, plastics are generally preferred. Preferred materials include polycarbonate and polyphenylene oxide, such as the polyphenylene oxide material commercially available from General Electric Company under the trademark Valox~.
The sheath portion of the plunger, which slidably WO95/26211 231~3~8n3 r_l _. /19 ~
rnnt~rtS the inner w~all of ~the cylindrical barrel, can be f ormed of any suitable material which is advAntAgPnu~ly employed in the envil~ t~ with which the plunger is associated Preferred materials of construction include rubber materials, with natural rubber being pref erred .
The syringe of this invention; nrl lmlPA at least one radially outwardly extending mrllntin~ lug 26 located at or near the outer proximal end of the barrel. The ~ .nting lug has distal surface 70 (Fig. 4~ having first end 72 and second end 74 which def ine a constrained portion of the barrel. The lugs can be provided with reinforcing ribs 76. The lug has a crown shape, i.e., the center of the distal surface o~ the lug is distally offset from the ends of the lug. The distal surface of the lug preferably is ArrllAtPly shaped. In a preferred pmhQ~limPnt, as illustrated best in Figs. 5 and 6, the syringe comprises a pair of mrllnting lugs spaced~180 degrees apart with respect to the barrel.
The lug can comprise a generally solid crowned shoulder, as ~Pr; rtP~l in Fig. 1, a reinforced ribbed design, such as is depicted in Figs. 2, 4, 5 and 6, or any other shape which provides the advantages described herein .
The preferred thickness X of the=crown, i.e., the amount by which the center of the distal surface of the lug is distally offset frQm the ends of the lug (see Fig. 5), is detPrminp~l primarily by the modulus and yield strength of the plastic, injection rressures and syringe wall tll;rknPAs. In preferred ' rt1ir ~, the crown thickness is at least about 0 . 025 cm ( 0 . 01 inch) and more preferably, at least about 0.060 cm (0.025 inch). For a syringe described above, a crown thickness of 0.075 cm (0.030 inch) is most preferred for injection pressures of 300-400 PSI (21.1-28.1 kg/cm2). ~Iigher pressures would require more crown while lower pressures would re~uire less.
WO 95/26211 ~ 1 8 2 ~ 0 3 P~ g _ g While Applicants do not wish to be bound by theoretical -hAn;qmq, ~ c~;nn plots from extensive finite element analyses suggest that unconstrained portions of the syringe , e . g ., portions between the 5 lugs, during inj ection are pulled f orward by inj ection forces, causing the lugs to curl and forcing the front edges of the lugs into the mmlnt;ng plate, thus rnnr~nt~ating stresses at the end points of the lugs.
The crowned lug design of this invention permits the lO center of the lug to contact the ~;ng plate firæt during high pressure injections. The natural deflection of the syringe under such high injection pressures f lattens the lug and distributes the f orces over a larger surface area, thus reducing the overall stress in 15 the lugs.
In another - -';m~nt depicted in Fig. 7, the syringe ;nrlil~lP,q cylindrical collar 90 adapted to fit over and attach to the proximal end of the cylindrical barrel. The collar can be attached to the barrel by 20 conv~n~innAl means, e.g., by a snap ~it or by threading engagement. The collar has at least one radially outwardly ,~ n~;nj mounting lug located at or near the outer proximal end of the collar. The lug has a distal surface having first and second ends defining a 25 constrained portion of the collar, which lug is crown shaped, such that the center of the distal surface of the lug is distally offse~ from the ends of the lug, as defined above. This "two-piece" design provides several advantages. First, the mating collar can be fabricated 30 of a different, e.g., higher modulus, plastic than the barrel inasmuch as it can be assem.bled onto the barrel - after the autoclave cycle. Second, any changes to the injector mounting plate which interfaces with the syringe could be ~cc -'-ted by changing only the 35 collar, and conse~uently would not nPr~qs-~ily affect that portion of the pref illed syringe subj ect to re~ulatory approval. In other words, any design changes WO 9~/262~ liS
to the exterior of a one-piece syringe could require recertification of the entire prefilled package. Third, this "two-piece" design featuring a collar can be easily and readily adapted to various power inj ectors merely by 5 designing a separate collar for each type of injector/syringe t;ng interface.
A power injector for use with the syringe described ahove comprises a tin~ plate adapted to receive a syringe as de6cribed above, and a driving member 10 ;nr~ head and shaft Pl R, The head and shaft Pl' ' R of the driving member can selectively engage the plunger of the syringe by any of a variety of conV~nt; nn;~l technigues well known in the art .
As noted, it is an advantageous feature that this 15 invention enables pref illed syringes f or use in f ront -loading power injectors to be fAhr; r~ted of lower modulus plastics such as a methylpentene copolymer and polypropylene. However, the syringe according to this invention can be fabricated of any suitable plastic such 20 as polyr~rhrm~tP~ polysulfone, polyethylene terPrhth~ te, amorphous polyolefir~, polypropylene, polyphenylene oxide, methylpentene copolymer and the like. A preferred plastic is a methylpentene copolymer available from Mitsui PetrochemiCal Industries, Ltd., 25 New York, NY, under the tr~lPn~ TPX RT18; having the structural formula ~ CH2 - C~z ~ n CHz CH~ CH3 ) 2 In any event, the use of this invention in conjunction with higher modulus plastics, such as PET, results in improved overall reliability and facilitates high injection forces. Additionally, the crowned lug design 35 of this invention enables the lug to be fabricated from less material, thus saving material costs.
The syringe of thi s invention can be used in ~182803 WO 95/26211 ~ S
conjunction with any liquid Pre~erred liquids include therapeutic and/or diagnostic agents. In particularly preferred Pmhnr1;r^ntc, the liquid is a diagnostic imaging contrast media comprising a diagnostic imaging 5 contrast agent. In the most preferred embodiments, the li~id is an x-ray contrast media featuring an x-ray contrast agent. A particularly preferred x-ray contrast agent is iohexol. Other contrast media for x-ray imaging which are in commercial or rlin;l-~l use include 10 i~-fli~ n~l, metri7~mlflP, ;~rs~m;~ ioversol, iotrolan, iopromide, ioxalan, hexabrix (i~ g~tP --3ll lm;n P and ioxaglate sodium), iothalamate meglumine, iothalamate sodium, diatrizoate meglumine and diatrisoate sodium.
The invention is also useful in conjunction with plastic 15 syringes filled with liquid contrast media for ultrasound imaging and magnetic resonance imaging procedures .
It will be seen that the invention provides a syringe which can be fabricated of low strength, 20 autoclavable plastics such as a methyl rPntPnP copolymer or polypropylene and used in conjunction with commercially available power inj ectors; which can be prefilled with the contrast media iohexol and used in conjunction with commercially available power injectors;
25 and which more uni~ormly distributes injection pressure across the lug face, thus improving the load bearing ef f iciency of the mounting lugs and providing improved overall reliability.
The invention has been described in detail with 30 particular rPfPrPnt P to certain preferred Pmhof~;mpnts thereof, but it will be understood that variations and modifications can be e~fected within the scope of t~e invention
Claims (11)
1. A plastic syringe comprising:
a cylindrical barrel for receiving a liquid;
a plunger axially reciprocable within said barrel for discharging the liquid therefrom;
a discharge extension at the distal end of said barrel terminating in a discharge outlet;
at least one radially outwardly extending mounting lug located at or near the outer proximal end of said barrel, said lug having a distal surface having first and second ends and being shaped such that the center of the distal surface of said lug is distally offset from the ends of said lug.
a cylindrical barrel for receiving a liquid;
a plunger axially reciprocable within said barrel for discharging the liquid therefrom;
a discharge extension at the distal end of said barrel terminating in a discharge outlet;
at least one radially outwardly extending mounting lug located at or near the outer proximal end of said barrel, said lug having a distal surface having first and second ends and being shaped such that the center of the distal surface of said lug is distally offset from the ends of said lug.
2. A plastic syringe comprising:
a cylindrical barrel for receiving a liquid;
a plunger axially reciprocable within said barrel for discharging the liquid therefrom;
a discharge extension at the distal end of said barrel terminating in a discharge outlet;
a cylindrical collar adapted to fit over and attach to the proximal end of said cylindrical barrel;
at least one radially outwardly extending mounting lug located at or near the outer proximal end of said collar, said lug having a distal surface having first and second ends and being shaped such that the center of the distal surface of said lug is distally offset from the ends of said lug.
a cylindrical barrel for receiving a liquid;
a plunger axially reciprocable within said barrel for discharging the liquid therefrom;
a discharge extension at the distal end of said barrel terminating in a discharge outlet;
a cylindrical collar adapted to fit over and attach to the proximal end of said cylindrical barrel;
at least one radially outwardly extending mounting lug located at or near the outer proximal end of said collar, said lug having a distal surface having first and second ends and being shaped such that the center of the distal surface of said lug is distally offset from the ends of said lug.
3. The plastic syringe of claim 1 or 2, comprising two of said mounting lugs spaced 180 degrees apart with respect to said barrel.
4. The plastic syringe of any preceding claim, wherein the center of the distal surface of said lug is distally offset by at least 0.025 cm from the ends of said lug.
5. The plastic syringe of any preceding claim, wherein the center of the distal surface of said lug is distally offset by at least 0.06 cm from the ends of said lug.
6. The plastic syringe of any preceding claim, wherein said liquid comprises a diagnostic imaging contrast agent .
7. The plastic syringe of claim 6 wherein said diagnostic imaging contrast agent is an x-ray contrast agent .
8. The plastic syringe of claim 7 wherein said x-ray contrast agent is selected from the group consisting of iohexol, iodixanol, ioversol, metrizamide, iopamidol, iotrolan, iopromide, ioxalan, hexabrix, iothalamate meglumine, iothalamate sodium, diatrizoate meglumine and diatrizoate sodium.
9. The plastic syringe of claim 8 wherein said x-ray contrast agent is iohexol.
10. The plastic syringe of any preceding claim, wherein said plastic is selected from the group consisting of polycarbonate, polysulfone, polyethylene terephthalate, amorphous polyolefin, polyphenylene oxide, polypropylene and methylpentene copolymer.
11. A power injector system comprising a mounting plate adapted to receive a syringe, a driving mechanism including head and shaft elements, and a plastic syringe according to any preceding claim mounted on said plate, wherein the plunger of said syringe selectively engages with the head and shaft elements of said driving mechanism .
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/219,598 | 1994-03-29 | ||
| US08/219,598 US5535746A (en) | 1994-03-29 | 1994-03-29 | Prefilled syringe for use with power injector |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2182803A1 true CA2182803A1 (en) | 1995-10-05 |
Family
ID=22819938
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002182803A Abandoned CA2182803A1 (en) | 1994-03-29 | 1995-03-29 | Pre-filled syringe with lugs |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5535746A (en) |
| EP (1) | EP0752894B1 (en) |
| JP (1) | JP3607293B2 (en) |
| KR (1) | KR970701571A (en) |
| CN (1) | CN1145034A (en) |
| AU (1) | AU2078895A (en) |
| CA (1) | CA2182803A1 (en) |
| CZ (1) | CZ265796A3 (en) |
| DE (1) | DE69507018T2 (en) |
| ES (1) | ES2125608T3 (en) |
| FI (1) | FI963846A (en) |
| HU (1) | HUT76020A (en) |
| MX (1) | MX9604421A (en) |
| NO (1) | NO964106L (en) |
| WO (1) | WO1995026211A1 (en) |
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| CN107106761B (en) | 2014-10-28 | 2020-11-03 | 拜耳医药保健有限公司 | Self-orienting pressure jacket and interface of pressure jacket to syringe |
| RU2017118366A (en) | 2014-10-28 | 2018-11-30 | БАЙЕР ХелсКер ЛЛСи | HIGH-PRESSURE SELF-ORIENTATING CASING AND HIGH PRESSURE CASING JOINING MECHANISM AND INJECTOR |
| NO2689315T3 (en) | 2014-10-28 | 2018-04-14 | ||
| US9480797B1 (en) | 2015-10-28 | 2016-11-01 | Bayer Healthcare Llc | System and method for syringe plunger engagement with an injector |
| US10835674B2 (en) | 2015-11-13 | 2020-11-17 | Bayer Healthcare Llc | Nested syringe assembly |
| TWI737812B (en) * | 2016-09-16 | 2021-09-01 | 美商拜耳保健公司 | Pressure jacket having syringe retaining element and fluid injector for delivering fluid to a patient |
| ES2899324T3 (en) | 2017-01-24 | 2022-03-10 | Bayer Healthcare Llc | Injection systems and syringe adapters for use therewith |
| US10912897B2 (en) * | 2017-05-04 | 2021-02-09 | Indumathi Prakash | Single-use syringe |
| CN107875486B (en) * | 2017-12-28 | 2023-11-24 | 山西阳光中天医疗器械有限公司 | Handheld grease injector and operation method thereof |
| US11191893B2 (en) | 2018-01-31 | 2021-12-07 | Bayer Healthcare Llc | System and method for syringe engagement with injector |
| PL3758777T3 (en) | 2018-02-27 | 2023-06-12 | Bayer Healthcare, Llc | Syringe plunger engagement mechanism |
| WO2021142322A1 (en) | 2020-01-10 | 2021-07-15 | Real Isolates, Llc | Methods for obtaining compounds from a plant or fungus material, respective compositions, and uses thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3738539A (en) * | 1970-05-08 | 1973-06-12 | American Hospital Supply Corp | Syringe with self-returnable plunger |
| US3811441A (en) * | 1972-02-10 | 1974-05-21 | Survival Technology | Cartridge syringe |
| US4861581A (en) * | 1986-12-05 | 1989-08-29 | Cancer Biologics, Inc. | Detection of necrotic malignant tissue and associated therapy |
| US5019371A (en) * | 1990-11-21 | 1991-05-28 | Mallinckrodt Medical, Inc. | Novel x-ray contrast agents, compositions and methods |
| AU642066B2 (en) * | 1991-01-25 | 1993-10-07 | Nanosystems L.L.C. | X-ray contrast compositions useful in medical imaging |
| US5300031A (en) * | 1991-06-07 | 1994-04-05 | Liebel-Flarsheim Company | Apparatus for injecting fluid into animals and disposable front loadable syringe therefor |
| US5383858B1 (en) * | 1992-08-17 | 1996-10-29 | Medrad Inc | Front-loading medical injector and syringe for use therewith |
| US5254101A (en) * | 1992-11-27 | 1993-10-19 | Medrad, Inc. | Fluid presence indicator for rotatable syringe |
-
1994
- 1994-03-29 US US08/219,598 patent/US5535746A/en not_active Expired - Lifetime
-
1995
- 1995-03-29 AU AU20788/95A patent/AU2078895A/en not_active Abandoned
- 1995-03-29 ES ES95913251T patent/ES2125608T3/en not_active Expired - Lifetime
- 1995-03-29 EP EP95913251A patent/EP0752894B1/en not_active Expired - Lifetime
- 1995-03-29 JP JP52505895A patent/JP3607293B2/en not_active Expired - Fee Related
- 1995-03-29 HU HU9602398A patent/HUT76020A/en unknown
- 1995-03-29 CA CA002182803A patent/CA2182803A1/en not_active Abandoned
- 1995-03-29 KR KR1019960704970A patent/KR970701571A/en not_active Application Discontinuation
- 1995-03-29 CN CN95192361A patent/CN1145034A/en active Pending
- 1995-03-29 DE DE69507018T patent/DE69507018T2/en not_active Expired - Fee Related
- 1995-03-29 WO PCT/GB1995/000719 patent/WO1995026211A1/en active IP Right Grant
- 1995-03-29 MX MX9604421A patent/MX9604421A/en unknown
- 1995-03-29 CZ CZ962657A patent/CZ265796A3/en unknown
-
1996
- 1996-09-26 FI FI963846A patent/FI963846A/en not_active Application Discontinuation
- 1996-09-27 NO NO964106A patent/NO964106L/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX9604421A (en) | 1997-12-31 |
| EP0752894A1 (en) | 1997-01-15 |
| FI963846A0 (en) | 1996-09-26 |
| CZ265796A3 (en) | 1997-05-14 |
| DE69507018T2 (en) | 1999-08-19 |
| ES2125608T3 (en) | 1999-03-01 |
| JPH10500320A (en) | 1998-01-13 |
| EP0752894B1 (en) | 1998-12-30 |
| NO964106L (en) | 1996-11-20 |
| AU2078895A (en) | 1995-10-17 |
| WO1995026211A1 (en) | 1995-10-05 |
| NO964106D0 (en) | 1996-09-27 |
| FI963846A (en) | 1996-09-26 |
| KR970701571A (en) | 1997-04-12 |
| US5535746A (en) | 1996-07-16 |
| JP3607293B2 (en) | 2005-01-05 |
| CN1145034A (en) | 1997-03-12 |
| HUT76020A (en) | 1997-06-30 |
| DE69507018D1 (en) | 1999-02-11 |
| HU9602398D0 (en) | 1996-11-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |