CA2180554A1 - Preserved ophthalmic drug compositions containing polymeric quaternary ammonium compounds - Google Patents

Preserved ophthalmic drug compositions containing polymeric quaternary ammonium compounds

Info

Publication number
CA2180554A1
CA2180554A1 CA002180554A CA2180554A CA2180554A1 CA 2180554 A1 CA2180554 A1 CA 2180554A1 CA 002180554 A CA002180554 A CA 002180554A CA 2180554 A CA2180554 A CA 2180554A CA 2180554 A1 CA2180554 A1 CA 2180554A1
Authority
CA
Canada
Prior art keywords
quaternary ammonium
compositions containing
ammonium compounds
polymeric quaternary
containing polymeric
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002180554A
Other languages
French (fr)
Other versions
CA2180554C (en
Inventor
Suketu Dipakbhai Desai
Diane S. Nelms
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Vision LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2180554A1 publication Critical patent/CA2180554A1/en
Application granted granted Critical
Publication of CA2180554C publication Critical patent/CA2180554C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears

Abstract

Disclosed are storage-stable preserved ophthalmic compositions containing acidic drugs in combination with polymeric quaternary ammonium compounds and boric acid.
CA002180554A 1994-11-16 1995-11-16 Preserved ophthalmic drug compositions containing polymeric quaternary ammonium compounds Expired - Lifetime CA2180554C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/340,763 US5603929A (en) 1994-11-16 1994-11-16 Preserved ophthalmic drug compositions containing polymeric quaternary ammonium compounds
US08/340,763 1994-11-16
PCT/US1995/014910 WO1996014829A1 (en) 1994-11-16 1995-11-16 Preserved ophthalmic drug compositions containing polymeric quaternary ammonium compounds

Publications (2)

Publication Number Publication Date
CA2180554A1 true CA2180554A1 (en) 1996-05-23
CA2180554C CA2180554C (en) 2001-08-21

Family

ID=23334841

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002180554A Expired - Lifetime CA2180554C (en) 1994-11-16 1995-11-16 Preserved ophthalmic drug compositions containing polymeric quaternary ammonium compounds

Country Status (13)

Country Link
US (2) US5603929A (en)
EP (1) EP0739197B1 (en)
JP (1) JP2954356B2 (en)
AT (1) ATE203897T1 (en)
AU (1) AU686917B2 (en)
CA (1) CA2180554C (en)
DE (1) DE69522094T2 (en)
DK (1) DK0739197T3 (en)
ES (1) ES2160722T3 (en)
GR (1) GR3036622T3 (en)
HK (1) HK1012556A1 (en)
PT (1) PT739197E (en)
WO (1) WO1996014829A1 (en)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5505953A (en) * 1992-05-06 1996-04-09 Alcon Laboratories, Inc. Use of borate-polyol complexes in ophthalmic compositions
US5683993A (en) * 1995-06-22 1997-11-04 Ciba Vision Corporation Compositions and methods for stabilizing polymers
JP2000505486A (en) * 1996-02-14 2000-05-09 アルコン ラボラトリーズ，インコーポレイテッド Polymeric quaternary ammonium compounds and their use as ophthalmic antimicrobial agents
JP4215277B2 (en) * 1996-08-09 2009-01-28 アルコン ラボラトリーズ，インコーポレイテッド Preservative system for pharmaceutical compositions containing cyclodextrin
PT948357E (en) * 1996-12-13 2002-10-31 Alcon Lab Inc USE OF ALCOHOLS OF LOW MOLECULAR WEIGHT IN OPHTHALMIC COMPOSITIONS
CN1229110C (en) * 1997-07-29 2005-11-30 阿尔康实验室公司 Ophthalmic compositions containing galactomannan polymers and borate
CN1222599C (en) 1997-11-26 2005-10-12 先进医用光学公司 Contact lens cleaning compsitions
US6063745A (en) 1997-11-26 2000-05-16 Allergan Mutli-purpose contact lens care compositions
JPH11249087A (en) * 1997-12-18 1999-09-17 Tome:Kk Light agent for contact lens
JP2006111636A (en) * 1997-12-26 2006-04-27 Astellas Pharma Inc Sustained release pharmaceutical composition
US7678836B2 (en) * 1999-11-04 2010-03-16 Fxs Ventures, Llc Method for rendering a contact lens wettable
ES2236180T3 (en) * 2000-01-25 2005-07-16 Alcon Inc. ANTIALERGIC OPHTHALMIC COMPOSITIONS SUITABLE FOR USE WITH CONTACT LENSES.
AR035509A1 (en) * 2000-12-21 2004-06-02 Alcon Inc SOLUTION OF IMPROVED ARTIFICIAL TEARS CONTAINING A COMBINATION OF THREE EMOLIENTS AND THE USE OF SUCH SOLUTION FOR THE MANUFACTURE OF A MEDICINAL PRODUCT
US7923469B2 (en) 2001-04-30 2011-04-12 Allergen, Inc. Compositions including vitamin-based surfactants and methods for using same
JP4286480B2 (en) * 2001-09-17 2009-07-01 株式会社メニコン Disinfectant
PT1586316E (en) * 2003-01-21 2008-05-28 Senju Pharma Co Aqueous liquid preparation containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid
CA2505836C (en) * 2004-05-06 2013-08-27 Alcon Inc. Topical brimonidine tartrate formulations that lack chlorine dioxide
US20060073184A1 (en) * 2004-09-29 2006-04-06 Bausch & Lomb Inc. Viscoelastic composition, methods of use and packaging device with anti-oxidant
KR20130080061A (en) * 2004-11-05 2013-07-11 센주 세이야꾸 가부시키가이샤 Aqueous eye drops with accelerated intraocular migration
JP5108234B2 (en) * 2005-02-07 2012-12-26 日本特殊陶業株式会社 Micro heater and sensor
US7947010B2 (en) 2005-07-08 2011-05-24 Depuy Products, Inc. Composition and system for wound decontamination
US20100130580A1 (en) * 2006-01-25 2010-05-27 Aciex Therapeutics, Inc. Formulations and Methods for Treating Dry Eye
US20090010850A1 (en) * 2007-05-24 2009-01-08 Ousler Iii George W Formulations and methods for treating dry eye
CA2621616A1 (en) * 2007-02-19 2008-08-19 Alcon Research, Ltd. Topical gatifloxacin formulations
US7705112B2 (en) * 2007-04-17 2010-04-27 Abbott Medical Optics Inc. Polyquaternium-1 synthesis methods
JP5668476B2 (en) 2007-10-08 2015-02-12 オーリニア・ファーマシューティカルズ・インコーポレイテッドＡｕｒｉｎｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． Ophthalmic composition comprising a calcineurin inhibitor or mTOR inhibitor
WO2009105534A2 (en) * 2008-02-21 2009-08-27 Ista Pharmaceuticals Ophthalmic nsaids as adjuvants
US9192571B2 (en) 2008-03-03 2015-11-24 Allergan, Inc. Ketorolac tromethamine compositions for treating or preventing ocular pain
MX2010009336A (en) 2008-03-17 2010-09-24 Alcon Res Ltd Aqueous pharmaceutical compositions containing borate-polyol complexes.
TWI544927B (en) 2008-03-17 2016-08-11 愛爾康研究有限公司 Pharmaceutical compositions having low concentration of surfactants for promoting bioavailability of therapeutic agents
TWI454289B (en) * 2008-04-03 2014-10-01 Alcon Res Ltd Use of cis-diol-containing polymer to inhibit the uptake of cationic biocides into hydrogel biomaterials
TW201038295A (en) 2009-04-17 2010-11-01 Alcon Res Ltd Aqueous ophthalmic compositions containing anionic therapeutic agents
ES2537385T3 (en) 2009-06-09 2015-06-08 Aurinia Pharmaceuticals Inc. Topical supply systems for ophthalmic use
TWI489997B (en) 2009-06-19 2015-07-01 Alcon Res Ltd Aqueous pharmaceutical compositions containing borate-polyol complexes
WO2012099142A1 (en) 2011-01-18 2012-07-26 千寿製薬株式会社 Bromfenac aqueous liquid composition having preservative efficiency
JP6128572B2 (en) * 2012-11-19 2017-05-17 ボシュ・アンド・ロム・インコーポレイテッドＢａｕｓｃｈ ＆ Ｌｏｍｂ Ｉｎｃｏｒｐｏｒａｔｅｄ Aqueous liquid composition containing 2-amino-3- (4-bromobenzoyl) phenylacetic acid
WO2014204952A1 (en) 2013-06-19 2014-12-24 Sentiss Research Center Stable bromfenac solution
US9693563B2 (en) 2013-08-20 2017-07-04 3M Innovative Properties Company Boron-silane polyether complex
WO2015087267A2 (en) 2013-12-12 2015-06-18 Sentiss Pharma Private Limited Stable bromfenac ophthalmic solution
US10632202B2 (en) 2016-03-04 2020-04-28 Johnson & Johnson Consumer Inc. Preservative containing compositions
US20190224275A1 (en) 2017-05-12 2019-07-25 Aurinia Pharmaceuticals Inc. Protocol for treatment of lupus nephritis
US20230159202A1 (en) * 2021-11-23 2023-05-25 Bausch + Lomb Ireland Limited Method for making a preservative-free packaged ophthalmic device product

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3931319A (en) * 1974-10-29 1976-01-06 Millmaster Onyx Corporation Capped polymers
US4027020A (en) * 1974-10-29 1977-05-31 Millmaster Onyx Corporation Randomly terminated capped polymers
US4136173A (en) * 1977-01-31 1979-01-23 American Home Products Corp. Mixed xanthan gum and locust beam gum therapeutic compositions
US4136178A (en) * 1977-01-31 1979-01-23 American Home Products Corp. Locust bean gum therapeutic compositions
US4136177A (en) * 1977-01-31 1979-01-23 American Home Products Corp. Xanthan gum therapeutic compositions
FR2508440B1 (en) * 1981-06-25 1985-11-08 Saint Gobain Isover PROCESS FOR THE PREPARATION OF ORTHOHYDROXYBENZYL ALCOHOLS
US4525346A (en) * 1981-09-28 1985-06-25 Alcon Laboratories, Inc. Aqueous antimicrobial ophthalmic solutions
US4407791A (en) * 1981-09-28 1983-10-04 Alcon Laboratories, Inc. Ophthalmic solutions
US4836986A (en) * 1984-09-28 1989-06-06 Bausch & Lomb Incorporated Disinfecting and preserving systems and methods of use
FR2588189B1 (en) * 1985-10-03 1988-12-02 Merck Sharp & Dohme LIQUID-GEL PHASE TRANSITION PHARMACEUTICAL COMPOSITION
US4822819A (en) * 1986-11-07 1989-04-18 Alcon Laboratories, Inc. Use of trimoprostil and derivatives in glaucoma therapy
US4822820A (en) * 1986-11-24 1989-04-18 Alcon Laboratories, Inc. Use of tri-methyl PG-F2 a and derivatives in glaucoma therapy
US5110493A (en) * 1987-09-11 1992-05-05 Syntex (U.S.A.) Inc. Ophthalmic NSAID formulations containing a quaternary ammonium preservative and a nonionic surfactant
NO175404C (en) * 1987-09-11 1994-10-12 Syntex Inc Process for the preparation of an eye preparation and preservative system for such a preparation
IE63392B1 (en) * 1988-02-08 1995-04-19 Insite Vision Inc Ophthalmic suspensions
US5188826A (en) * 1988-02-08 1993-02-23 Insite Vision Incorporated Topical ophthalmic suspensions
US5149693A (en) * 1988-03-09 1992-09-22 Alcon Laboratories, Inc. Combination of tobramycin and fluorometholone for topical ophthalmic use
US5149694A (en) * 1988-03-09 1992-09-22 Alcon Laboratories, Inc. Combination of tobramycin and dexamethasone for topical ophthalmic use
US5173507A (en) * 1988-07-18 1992-12-22 Alcon Laboratories, Inc. Prostaglandin combinations in glaucoma therapy
US4960799A (en) * 1988-09-13 1990-10-02 Ciba-Geigy Corporation Stabilized aqueous solutions of pharmaceutically acceptable salts of ortho-(2,6-dichlorophenyl)-aminophenylacetic acid for opthalmic use
US5037647A (en) * 1988-09-15 1991-08-06 Alcon Laboratories, Inc. Aqueous antimicrobial opthalmic solutions comprised of quaternary ammonium compound, citric acid, citrate and sodium chloride
US5145643A (en) * 1990-01-05 1992-09-08 Allergan, Inc. Nonoxidative ophthalmic compositions and methods for preserving and using same
JP3337218B2 (en) * 1992-05-06 2002-10-21 アルコン ラボラトリーズ，インコーポレイテッド Use of a borate-polyol complex in ophthalmic compositions
US5300287A (en) * 1992-11-04 1994-04-05 Alcon Laboratories, Inc. Polymeric antimicrobials and their use in pharmaceutical compositions
AU6021794A (en) * 1993-01-11 1994-08-15 Allergan, Inc. Ophthalmic compositions comprising benzyllauryldimethylammonium chloride

Also Published As

Publication number Publication date
ATE203897T1 (en) 2001-08-15
DK0739197T3 (en) 2001-10-29
AU4162296A (en) 1996-06-06
EP0739197A1 (en) 1996-10-30
DE69522094T2 (en) 2001-11-22
JP2954356B2 (en) 1999-09-27
ES2160722T3 (en) 2001-11-16
HK1012556A1 (en) 1999-08-06
WO1996014829A1 (en) 1996-05-23
US5603929A (en) 1997-02-18
EP0739197B1 (en) 2001-08-08
PT739197E (en) 2001-12-28
JPH09503791A (en) 1997-04-15
GR3036622T3 (en) 2001-12-31
DE69522094D1 (en) 2001-09-13
US5653972A (en) 1997-08-05
CA2180554C (en) 2001-08-21
AU686917B2 (en) 1998-02-12

Similar Documents

Publication Publication Date Title
CA2180554A1 (en) Preserved ophthalmic drug compositions containing polymeric quaternary ammonium compounds
CA2193337A1 (en) 1-phenyl-2-dimethylaminomethyl-cyclohexan-1-ol compounds as pharmaceutical active ingredients
CA2180816A1 (en) 6-dimethylaminomethyl-1-phenyl-cyclohexane compounds as pharmaceutical active ingredients
CA2028570A1 (en) Antimicrobial method and formulation employing type ii endoglycosidase and antimicrobial agent
CA2203033A1 (en) Compounds and compositions for delivering active agents
CA2322579A1 (en) Gelling ophthalmic compositions containing xanthan gum
CA2154424A1 (en) 1-phenyl-3-dimethylaminopropane compounds having a pharmaceutical effect
AU2656095A (en) Disinfectants and sanitizers with reduced eye irritation potential
CA2154652A1 (en) Pharmaceutical and dermocosmetic compositions containing equine colostrum
CA2194167A1 (en) Hair-growing agent
AU2034395A (en) Composition consisting of a dendrimer and an active substance occluded in the dendrimer, a process for the preparation of such a composition and a process for releasing the active substance
AU7702291A (en) Dietary fiber, its process and physiologically active composition containing the same as an active ingredient
CA2301176A1 (en) Self-binding shearform compositions
IL111533A0 (en) Quinoxalinedione derivatives, methods for the preparation thereof and pharmaceutical compositions containing the same
ZA9410235B (en) Slow-release insect-repellent formulations and uses
ZA200007415B (en) Amino acid derivatives and drugs containing the same as the active ingredient.
AU7472191A (en) Therapeutic composition containing a phenol compound and propolis useful against lipidic capside viruses, especially the herpes viruses
CA2294448A1 (en) Pharmaceutical combination preparations containing erythropoietin and modified haemoglobins
AU768217C (en) 2-methylpropionic acid derivatives and medicinal compositions containing the same
AU5260096A (en) Novel pyridonecarboxylic acid derivatives or salts thereof and antibacterial agent containing the same as active ingredient
HU9402648D0 (en) 3,4-dioxo-1-cyclobuten-1-yl-substituted (indolyl-alkyl)-pyridine- and -pyrimidine derivatives and antimigraine composition containing them as active componens
AU6667894A (en) Diamines as antimicrobial agents and use thereof in ophthalmic composition
AU4318397A (en) Novel 2,4-dioxopyrrolidine and 2,4-dioxotetrahydrofuran derivatives and medicines containing the same as the active ingredient
AU7467994A (en) Novel polysaccharide and radioprotective agent containing the same as active ingredient
AU6559390A (en) Antimicrobial method and formulation employing type ii endoglycosidase and antimicrobial agent

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20151116