CA2177823A1 - Poly-beta-1-->4-n-acetylglucosamine - Google Patents

Poly-beta-1-->4-n-acetylglucosamine

Info

Publication number
CA2177823A1
CA2177823A1 CA002177823A CA2177823A CA2177823A1 CA 2177823 A1 CA2177823 A1 CA 2177823A1 CA 002177823 A CA002177823 A CA 002177823A CA 2177823 A CA2177823 A CA 2177823A CA 2177823 A1 CA2177823 A1 CA 2177823A1
Authority
CA
Canada
Prior art keywords
glcnac
acetylglucosamine
beta
poly
polysaccharides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002177823A
Other languages
French (fr)
Other versions
CA2177823C (en
Inventor
John N. Vournakis
Sergio Finkielsztein
Ernest R. Pariser
Mike Helton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Marine Polymer Technologies Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CA002372026A priority Critical patent/CA2372026A1/en
Publication of CA2177823A1 publication Critical patent/CA2177823A1/en
Application granted granted Critical
Publication of CA2177823C publication Critical patent/CA2177823C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/042—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/12—Unicellular algae; Culture media therefor
    • C12N1/125—Unicellular algae isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/89—Algae ; Processes using algae

Abstract

A method of producing and purifying poly-.beta.-14-N-acetylglucosamine(p-GlcNAc)polysaccharide species and their derivatives is described. The polysaccharides produced by this method are free of proteins, and substantially free of single amino acids, and other organic and inorganic contaminants. These p-GlcNAc polysaccharides may be used commercially by the biomedical, pharmaceutical, and cosmetic industries in slow drug delivery systems, cell encapsulation systems, and treatments for the prevention of post-surgical adhesions. The figure shows the chemical structure of 100 % p-GlcNAc, wherein "n" is an integer from about 4,000 to about 150,000.
CA002177823A 1993-12-01 1994-12-01 Poly-beta-1-->4-n-acetylglucosamine Expired - Fee Related CA2177823C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002372026A CA2372026A1 (en) 1993-12-01 1994-12-01 Poly-beta-1->4-n-acetylglucosamine

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US160,569 1993-12-01
US08/160,569 US5622834A (en) 1993-12-01 1993-12-01 Method of isolating poly-β-1-4-N-acetylglucosamine from microalgal culture
PCT/US1994/013706 WO1995015343A1 (en) 1993-12-01 1994-12-01 POLY-β-1→4-N-ACETYLGLUCOSAMINE

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA002372026A Division CA2372026A1 (en) 1993-12-01 1994-12-01 Poly-beta-1->4-n-acetylglucosamine

Publications (2)

Publication Number Publication Date
CA2177823A1 true CA2177823A1 (en) 1995-06-08
CA2177823C CA2177823C (en) 2002-04-30

Family

ID=22577431

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002177823A Expired - Fee Related CA2177823C (en) 1993-12-01 1994-12-01 Poly-beta-1-->4-n-acetylglucosamine

Country Status (15)

Country Link
US (2) US5622834A (en)
EP (2) EP0731812B1 (en)
JP (3) JP3993633B2 (en)
CN (1) CN1142833B (en)
AT (1) ATE263785T1 (en)
AU (1) AU695850B2 (en)
CA (1) CA2177823C (en)
DE (1) DE69433692T2 (en)
DK (1) DK0731812T3 (en)
ES (1) ES2219659T3 (en)
IL (1) IL111825A0 (en)
NZ (1) NZ277662A (en)
PT (1) PT731812E (en)
TW (1) TW458987B (en)
WO (1) WO1995015343A1 (en)

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US20070086958A1 (en) * 2005-10-14 2007-04-19 Medafor, Incorporated Formation of medically useful gels comprising microporous particles and methods of use
EP1939302A1 (en) * 2005-10-17 2008-07-02 Yamaha Hatsudoki Kabushiki Kaisha Process for producing -chitin
ES2552842T3 (en) * 2007-02-19 2015-12-02 Marine Polymer Technologies, Inc. Hemostatic compositions and therapeutic regimens
US8932560B2 (en) 2007-09-04 2015-01-13 University of Maryland, College Parke Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells
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WO2009012438A2 (en) * 2007-07-18 2009-01-22 Marine Polymer Technologies Application of polymeric materials to screens to facilitate hemostasis and wound healing
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JP5833919B2 (en) 2008-04-24 2015-12-16 メドトロニック，インコーポレイテッド Protective gel based on chitosan and oxidized polysaccharide
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US8653319B2 (en) 2008-04-24 2014-02-18 Medtronic, Inc. Cold ionizing radiation sterilization
CA2780898A1 (en) 2009-11-13 2011-05-19 University Of Maryland, College Park Advanced functional biocompatible foam used as a hemostatic agent for compressible and non-compressible acute wounds
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CN107412256A (en) 2011-04-15 2017-12-01 海洋聚合物技术公司 Disease is treated with poly- N acetyl glucosamines nanofiber
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Also Published As

Publication number Publication date
JP2004211101A (en) 2004-07-29
EP0731812B1 (en) 2004-04-07
JPH09506126A (en) 1997-06-17
TW458987B (en) 2001-10-11
DE69433692D1 (en) 2004-05-13
ES2219659T3 (en) 2004-12-01
AU1296995A (en) 1995-06-19
CN1142833A (en) 1997-02-12
NZ277662A (en) 1998-04-27
EP1452546A2 (en) 2004-09-01
ATE263785T1 (en) 2004-04-15
DE69433692T2 (en) 2005-03-10
WO1995015343A1 (en) 1995-06-08
US5623064A (en) 1997-04-22
CA2177823C (en) 2002-04-30
EP0731812A4 (en) 1997-06-18
EP1452546A3 (en) 2004-10-13
US5622834A (en) 1997-04-22
PT731812E (en) 2004-08-31
AU695850B2 (en) 1998-08-27
IL111825A0 (en) 1995-01-24
CN1142833B (en) 2010-06-02
EP0731812A1 (en) 1996-09-18
DK0731812T3 (en) 2004-08-02
JP3993633B2 (en) 2007-10-17
JP2009079223A (en) 2009-04-16

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