CA2165663A1 - Diagnostic reagent stabilizer - Google Patents

Diagnostic reagent stabilizer

Info

Publication number
CA2165663A1
CA2165663A1 CA002165663A CA2165663A CA2165663A1 CA 2165663 A1 CA2165663 A1 CA 2165663A1 CA 002165663 A CA002165663 A CA 002165663A CA 2165663 A CA2165663 A CA 2165663A CA 2165663 A1 CA2165663 A1 CA 2165663A1
Authority
CA
Canada
Prior art keywords
diagnostic reagent
succinic acid
reagent stabilizer
salt
stabilizer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002165663A
Other languages
French (fr)
Other versions
CA2165663C (en
Inventor
Joseph E. Bateson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics Operations Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2165663A1 publication Critical patent/CA2165663A1/en
Application granted granted Critical
Publication of CA2165663C publication Critical patent/CA2165663C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • C12Q1/006—Enzyme electrodes involving specific analytes or enzymes for glucose
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/54—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/104998—Glucose, ketone, nitrate standard or control
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]
    • Y10T436/144444—Glucose
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2525—Stabilizing or preserving

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The inclusion of succinic acid or a salt thereof to stabilize compositions that include glucose oxidase and/or ferricyanide. Typically, the succinic acid or succinic acid salt is included in a diagnostic reagent utilized in test strips or test solutions useful for the analysis of glucose from a fluid sample.
CA002165663A 1993-06-21 1994-06-21 Diagnostic reagent stabilizer Expired - Lifetime CA2165663C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8026393A 1993-06-21 1993-06-21
US08/080,263 1993-06-21
PCT/US1994/007223 WO1995000662A1 (en) 1993-06-21 1994-06-21 Diagnostic reagent stabilizer

Publications (2)

Publication Number Publication Date
CA2165663A1 true CA2165663A1 (en) 1995-01-05
CA2165663C CA2165663C (en) 2004-11-23

Family

ID=22156257

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002165663A Expired - Lifetime CA2165663C (en) 1993-06-21 1994-06-21 Diagnostic reagent stabilizer

Country Status (9)

Country Link
US (1) US5627075A (en)
EP (1) EP0705348B1 (en)
JP (1) JP3839470B2 (en)
AU (1) AU680520B2 (en)
CA (1) CA2165663C (en)
DE (3) DE9422352U1 (en)
ES (1) ES2154249T3 (en)
NZ (1) NZ268301A (en)
WO (1) WO1995000662A1 (en)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6358722B1 (en) 1994-04-25 2002-03-19 Roche Vitamins, Inc. Heat tolerant phytases
US6699704B1 (en) 1994-04-25 2004-03-02 Roche Vitamins Inc. Heat tolerant phytases
WO1998020348A1 (en) * 1996-11-08 1998-05-14 Mercury Diagnostics, Inc. Opaque reaction matrix for the analysis of whole blood
CA2231948C (en) 1997-03-25 2010-05-18 F. Hoffmann-La Roche Ag Modified phytases
NZ330940A (en) 1997-07-24 2000-02-28 F Production of consensus phytases from fungal origin using computer programmes
JP3375040B2 (en) 1997-07-29 2003-02-10 松下電器産業株式会社 Substrate quantification method
AU760737B2 (en) * 1998-06-29 2003-05-22 Dsm Ip Assets B.V. Phytase formulation
EP0969089A1 (en) * 1998-06-29 2000-01-05 F. Hoffmann-La Roche Ag Phytase formulation
US20050103624A1 (en) 1999-10-04 2005-05-19 Bhullar Raghbir S. Biosensor and method of making
US6413213B1 (en) 2000-04-18 2002-07-02 Roche Diagnostics Corporation Subscription based monitoring system and method
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
US6821410B2 (en) * 2001-03-07 2004-11-23 Matsushita Electric Industrial Co., Ltd. Biosensor and method of substrate quantification
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
US7025774B2 (en) 2001-06-12 2006-04-11 Pelikan Technologies, Inc. Tissue penetration device
US20030077702A1 (en) * 2001-10-23 2003-04-24 Rajiv Shah Method for formulating a glucose oxidase enzyme with a desired property or properties and a glucose oxidase enzyme with the desired property
AU2002352959B2 (en) * 2001-11-26 2008-04-10 Ischemia Technologies, Inc. Electrochemical detection of ischemia
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7708701B2 (en) 2002-04-19 2010-05-04 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US6759190B2 (en) * 2002-06-15 2004-07-06 Acon Laboratories, Inc. Test strip for detection of analyte and methods of use
AU2003234944A1 (en) * 2002-08-27 2004-03-18 Bayer Healthcare, Llc Methods of Determining Glucose Concentration in Whole Blood Samples
US7572237B2 (en) * 2002-11-06 2009-08-11 Abbott Diabetes Care Inc. Automatic biological analyte testing meter with integrated lancing device and methods of use
US7175897B2 (en) * 2002-12-17 2007-02-13 Avery Dennison Corporation Adhesive articles which contain at least one hydrophilic or hydrophobic layer, method for making and uses for same
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
US8148164B2 (en) 2003-06-20 2012-04-03 Roche Diagnostics Operations, Inc. System and method for determining the concentration of an analyte in a sample fluid
US8679853B2 (en) 2003-06-20 2014-03-25 Roche Diagnostics Operations, Inc. Biosensor with laser-sealed capillary space and method of making
US8071030B2 (en) 2003-06-20 2011-12-06 Roche Diagnostics Operations, Inc. Test strip with flared sample receiving chamber
CA2529657C (en) 2003-06-20 2011-04-12 F. Hoffmann-La Roche Ag Test strip with slot vent opening
EP1671096A4 (en) 2003-09-29 2009-09-16 Pelikan Technologies Inc Method and apparatus for an improved sample capture device
EP1680014A4 (en) 2003-10-14 2009-01-21 Pelikan Technologies Inc Method and apparatus for a variable user interface
EP1706026B1 (en) 2003-12-31 2017-03-01 Sanofi-Aventis Deutschland GmbH Method and apparatus for improving fluidic flow and sample capture
US7807043B2 (en) * 2004-02-23 2010-10-05 Oakville Hong Kong Company Limited Microfluidic test device
US8828203B2 (en) 2004-05-20 2014-09-09 Sanofi-Aventis Deutschland Gmbh Printable hydrogels for biosensors
US9775553B2 (en) 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
WO2005120365A1 (en) 2004-06-03 2005-12-22 Pelikan Technologies, Inc. Method and apparatus for a fluid sampling device
TW200718785A (en) 2005-11-10 2007-05-16 Toyo Boseki A process for improving the thermal stability of a composition containing a soluble coenzyme conjugated glucose dehydrogenase (GDH)
EP3187866B1 (en) * 2007-12-10 2019-04-17 Ascensia Diabetes Care Holdings AG Electrochemical test sensor
WO2009126900A1 (en) 2008-04-11 2009-10-15 Pelikan Technologies, Inc. Method and apparatus for analyte detecting device
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
KR101727422B1 (en) 2013-03-15 2017-04-14 에프. 호프만-라 로슈 아게 Methods of scaling data used to construct biosensor algorithms as well as devices, apparatuses and systems incorporating the same
CN105247357B (en) 2013-03-15 2017-12-12 豪夫迈·罗氏有限公司 It is horizontal with the therefrom method to analyte concentration fail-safe and with reference to its unit and system that high in antioxidants is detected during electrochemical measurement
WO2014140164A1 (en) 2013-03-15 2014-09-18 Roche Diagnostics Gmbh Methods of using information from recovery pulses in electrochemical analyte measurements as well as devices, apparatuses and systems incorporating the same
KR101732300B1 (en) 2013-03-15 2017-05-02 에프. 호프만-라 로슈 아게 Methods of failsafing electrochemical measurements of an analyte as well as devices, apparatuses and systems incorporating the same
JP6526193B2 (en) 2014-11-03 2019-06-05 エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト Electrode arrangement for electrochemical test elements and method of use thereof
EP3523639A4 (en) 2016-10-05 2020-06-03 H. Hoffnabb-La Roche Ag Detection reagents and electrode arrangements for multi-analyte diagnostic test elements, as well as methods of using the same

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1598322C2 (en) * 1967-06-30 1973-09-13 Calbiochem, Los Angeles, Calif. (Vst.A.) Laboratory reagent for the determination of glucose
IT986838B (en) * 1972-05-12 1975-01-30 Sclavo Inst Sieroterapeut COMPLEX OF REAGENTS FOR THE ENZYMATIC DETER MINATION OF GLUCOSE GLUCOSE SYSTEM OXIDASE PEROXIDASE DASES WITH MANUAL AND AUTOMATED METHODS CO WITH READING AT TERM OR IN KINETICS
US4189536A (en) * 1977-11-09 1980-02-19 Hycel, Inc. Reagent systems, enzymatic assays and compositions therefor
CA1187388A (en) * 1978-09-20 1985-05-21 American Monitor Corporation Stabilization of working reagent solutions containing nadh, nadph, and/or enzymes, and the use of such stabilized reagents in enzymes or substrate assays
US4229369A (en) * 1979-04-25 1980-10-21 Hycel, Inc. Tris (hydroxymethyl) aminomethane salt of 2-mercaptosuccinic acid
JPS6033479B2 (en) * 1980-07-30 1985-08-02 協和醗酵工業株式会社 Method for quantifying hydrogen peroxide
JPS57138389A (en) * 1981-02-17 1982-08-26 Toyobo Co Ltd Stable urease composition
JPS5886083A (en) * 1981-11-12 1983-05-23 Wako Pure Chem Ind Ltd Stabilizing agent for glycerol-3-phosphoric acid oxidase
JPS58128898A (en) * 1982-01-26 1983-08-01 Fuji Photo Film Co Ltd Treating liquid for making offset master hydrophilic
US4529525A (en) * 1982-08-30 1985-07-16 Colgate-Palmolive Co. Stabilized enzyme-containing detergent compositions
JPS59182361A (en) * 1983-03-31 1984-10-17 Kyowa Medetsukusu Kk Determination of hydrogen peroxide
GB8311314D0 (en) * 1983-04-26 1983-06-02 Unilever Plc Aqueous enzyme-containing compositions
JPS60108753A (en) * 1983-11-18 1985-06-14 Fuji Photo Film Co Ltd Multilayer chemical analysis element
JPS62502653A (en) * 1985-02-11 1987-10-15 トラベノ−ル‐ジエネンテツク、ダイアグノスチクス Stabilized enzyme substrate solution
US4900475A (en) * 1985-07-26 1990-02-13 Colgate-Palmolive Co. Stabilized built liquid detergent composition containing enzyme
JPS63202381A (en) * 1987-02-17 1988-08-22 Agency Of Ind Science & Technol Stabilization of enzyme
US5116729A (en) * 1989-03-10 1992-05-26 Miles Inc. Stabilization of oxidase enzyme-based test strips
US5185247A (en) * 1989-03-10 1993-02-09 Miles Inc. Stabilization of oxidase enzyme-based test strips

Also Published As

Publication number Publication date
DE705348T1 (en) 2000-10-05
JP3839470B2 (en) 2006-11-01
ES2154249T1 (en) 2001-04-01
NZ268301A (en) 1997-10-24
AU680520B2 (en) 1997-07-31
JPH08511942A (en) 1996-12-17
EP0705348B1 (en) 2001-08-08
DE69427911D1 (en) 2001-09-13
EP0705348A1 (en) 1996-04-10
WO1995000662A1 (en) 1995-01-05
AU7116094A (en) 1995-01-17
DE69427911T2 (en) 2002-04-04
EP0705348A4 (en) 1998-05-27
CA2165663C (en) 2004-11-23
US5627075A (en) 1997-05-06
ES2154249T3 (en) 2001-12-16
DE9422352U1 (en) 2000-11-09

Similar Documents

Publication Publication Date Title
CA2165663A1 (en) Diagnostic reagent stabilizer
US5885790A (en) Diagnostic compositions and devices utilizing same
US3235337A (en) Diagnostic compositions and test indicators
BR0204761A (en) Stabilized tetrazolium phenazine reagent compositions and processes for using them
CA2142868A1 (en) Chemical and microbiological test kit
WO2001096596A3 (en) Compositions containing a urea derivative dye for detecting an analyte
JPS5592698A (en) Test strip for glucose determination
ATE125871T1 (en) METHOD AND REAGENT FOR DETERMINING AN ANALYTE BY ENZYMATIC MEANS OF AN IRON-III-CYAN/IRON-III COMPOUND SYSTEM.
CA2140794A1 (en) Assay for the determination of protein in a biological sample
AU7452687A (en) Process and reagent for the specific determination of fructosamine
Flohe et al. Some hints to avoid pitfalls in quantitative determination of glutathione peroxidase (EC 1.11. 1.9)
Mamoru et al. A new colorimetric method for determination of serum glucose
CA2028593A1 (en) Stabilized enzyme compositions
US5525481A (en) Enzymatic Reagents for ethanol assay containing diamino compounds
EP0198322B1 (en) Method for the determination of plasminogen activators
CA2050677A1 (en) Visual blood glucose concentration test strip
GB1569392A (en) Method and reagent for the determin. of antithrombin iii
EP0231126A3 (en) Fluorescent dyes and biological and analytical uses thereof
DE2301999A1 (en) ENZYMATIC TEST
DE3473475D1 (en) Process for determining substrate or enzymatic activity
CA2024052A1 (en) Enzymatic method for determining analyte concentrations
JPS62285782A (en) Birilubin specific enzyme and its use in analysis
EP0498260B1 (en) Procedure for stabilization of 1-methylhydantoinase, use of a stabilized 1-methylhydantoinase for the determination of an analyte, corresponding determination procedure, and useful means therefor
EP0542107A1 (en) Detection of analytes in saliva using peroxide-peroxidase test systems
Nabirahni et al. Development and application of an immobilized enzyme electrode for the determination of sulfite in foods and feeds

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20140623