CA2154354A1 - Method for performing thoracoscopic cardiac bypass procedures - Google Patents
Method for performing thoracoscopic cardiac bypass proceduresInfo
- Publication number
- CA2154354A1 CA2154354A1 CA002154354A CA2154354A CA2154354A1 CA 2154354 A1 CA2154354 A1 CA 2154354A1 CA 002154354 A CA002154354 A CA 002154354A CA 2154354 A CA2154354 A CA 2154354A CA 2154354 A1 CA2154354 A1 CA 2154354A1
- Authority
- CA
- Canada
- Prior art keywords
- patient
- artery
- heart
- chest
- coronary
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
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- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0468—Liquids non-physiological
- A61M2202/047—Liquids non-physiological cardioplegic
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
- A61M2205/3344—Measuring or controlling pressure at the body treatment site
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- A61M2205/00—General characteristics of the apparatus
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- A61M25/00—Catheters; Hollow probes
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Abstract
A method for closed chest cardiac surgical intervention relies on viewing the cardiac region through a thoracoscope (34) or other viewing scope and endovascularly partitioning the patient's arterial system at a location within the ascending aorta. The cardiopulmonary bypass (56) and cardioplegia can be induced, and a variety of surgical procedures performed on the stopped heart using percutaneously introduced tools.
The method of the present invention will be particularly suitable for forming coronary artery bypass grafts, where an arterial blood source is created using least invasive surgical technique, and the arterial source is connected to a target location within a coronary artery while the patient is under cardiopulmonary bypass and cardioplegia.
The method of the present invention will be particularly suitable for forming coronary artery bypass grafts, where an arterial blood source is created using least invasive surgical technique, and the arterial source is connected to a target location within a coronary artery while the patient is under cardiopulmonary bypass and cardioplegia.
Description
WO94/18881 ~ 3~ PCT~S94/00305 METHOD FOR PERFORMING THORACOSCOPIC CARDIAC BYPASS PROCEDURES
8AC~r-ROUND ~F TH~ lNv~.LlON
l. Field of the Invention The present invention relates generally to thoracoscopic methods for performing cardiac procedures.
More particularly, the present invention relates to thoracoscopic methods for performing procedures externally on or internally within the heart while the patient's chest is unopened, the patient's heart is stopped, and the patient is supported by cardiopulmonary bypass.
Coronary artery disease rPm~ i n~ the leading cause of morbidity and mortality in Western societies.
Coronary artery disease is manifested in a number of ways. For example, disease of the coronary arteries can lead to insufficient blood flow resulting in the discomfort and risks of angina and ischemia. In severe cases, acute blockage of coronary blood flow can result in myocardial infarction, l~i ng to immediate death or damage to the myocardial tissue.
A number of approaches have been developed for treating coronary artery disease. In less severe cases, it is often sufficient to treat the symptoms with pharmaceuticals and lifestyle modification to lessen the underlying causes of disease. In more severe cases, the coronary blockage(s) can often be treated endovascularly using t~hn; ques such as balloon angioplasty, atherectomy, laser ablation, stents, hot tip probes, and the like.
In cases where pharmaceutical treatment and/or endovascular approaches have failed or are likely to fail, it is often ~c~-crcary to perform a coronary artery bypass graft procedure using open surgical techniques.
Such tPchniques require that the patient's sternum be opened and the chest be spread apart to provide access to WO94/18881 PCT~S94/00305 the heart. A source of arterial blood is then connected to a coronary artery downstream from an occlusion while the patient is maintained under cardioplegia and is supported by cardiopulmonary bypass. The source of blood is often the left or right internal mammary artery, and the target coronary artery can be the left anterior descending artery or any other coronary artery which might be narrowed or occluded.
While very effective in many cases, the use of open surgery to perform coronary artery bypass grafting is highly traumatic to the patient. The procedure requires immediate postoperative care in an intensive care unit, a total period of hospitalization of seven to ten days, and a recovery period that can be as long as six to eight weeks.
It would therefore be desirable to provide other, less traumatic methods and tec-hn;ques for performing coronary artery bypass grafting. It would be particularly desirable if such te~hn;ques did not require opening of the patient's sternum, and might be even more desirable if such techn;ques could be performed using thoracoscopic methods. Such thoracoscopic methods could decrease morbidity and mortality, cost, and recovery time when compared to conventional open surgical coronary bypass procedures. In addition, such methods could be even more efficacious than open-surgical bypass procedures.
8AC~r-ROUND ~F TH~ lNv~.LlON
l. Field of the Invention The present invention relates generally to thoracoscopic methods for performing cardiac procedures.
More particularly, the present invention relates to thoracoscopic methods for performing procedures externally on or internally within the heart while the patient's chest is unopened, the patient's heart is stopped, and the patient is supported by cardiopulmonary bypass.
Coronary artery disease rPm~ i n~ the leading cause of morbidity and mortality in Western societies.
Coronary artery disease is manifested in a number of ways. For example, disease of the coronary arteries can lead to insufficient blood flow resulting in the discomfort and risks of angina and ischemia. In severe cases, acute blockage of coronary blood flow can result in myocardial infarction, l~i ng to immediate death or damage to the myocardial tissue.
A number of approaches have been developed for treating coronary artery disease. In less severe cases, it is often sufficient to treat the symptoms with pharmaceuticals and lifestyle modification to lessen the underlying causes of disease. In more severe cases, the coronary blockage(s) can often be treated endovascularly using t~hn; ques such as balloon angioplasty, atherectomy, laser ablation, stents, hot tip probes, and the like.
In cases where pharmaceutical treatment and/or endovascular approaches have failed or are likely to fail, it is often ~c~-crcary to perform a coronary artery bypass graft procedure using open surgical techniques.
Such tPchniques require that the patient's sternum be opened and the chest be spread apart to provide access to WO94/18881 PCT~S94/00305 the heart. A source of arterial blood is then connected to a coronary artery downstream from an occlusion while the patient is maintained under cardioplegia and is supported by cardiopulmonary bypass. The source of blood is often the left or right internal mammary artery, and the target coronary artery can be the left anterior descending artery or any other coronary artery which might be narrowed or occluded.
While very effective in many cases, the use of open surgery to perform coronary artery bypass grafting is highly traumatic to the patient. The procedure requires immediate postoperative care in an intensive care unit, a total period of hospitalization of seven to ten days, and a recovery period that can be as long as six to eight weeks.
It would therefore be desirable to provide other, less traumatic methods and tec-hn;ques for performing coronary artery bypass grafting. It would be particularly desirable if such te~hn;ques did not require opening of the patient's sternum, and might be even more desirable if such techn;ques could be performed using thoracoscopic methods. Such thoracoscopic methods could decrease morbidity and mortality, cost, and recovery time when compared to conventional open surgical coronary bypass procedures. In addition, such methods could be even more efficacious than open-surgical bypass procedures.
2. Descri~tion o~ the Backqroun~ Art Conventional thoracoscopic t~chn;ques are described in Landreneau et al. (1992) Ann. Thorac. Surg.
54: 800-807. Conventional open surgical procedures for performing coronary artery bypass grafting are described in Kirklin and Bar~att Boyes, Cardiac Surgery, John Wiley & Sons, Inc. New York, lg93 (2nd Ed.). Copending application Serial No. 07/730,599, assigned to the assignee of the present application, describes a catheter which is insertable into a patient's arterial system and WO94/18881 21~ PCT~S9~/00305 includes a distal balloon which can be expanded to occlude the A ~ce~ g aorta. The coronary ostia remain unblocked so that the heart and proximal ascending aorta may be isolated while the patient is on cardiopulmonary bypass. This catheter is particularly intended to be used in heart valve replacement procedures.
8~NNARY OF THE 1L~V~1ON
According to the present invention, a method for closed-chest cardiac surgical intervention relies on viewing the region of the heart through a percutaneously positioned viewing scope, such as a thoracoscope. The patient's arterial system will be partitioned during such interventional procedures at a location within the ascending aorta between the brachioc~ph~lic artery and the coronary ostia. In a preferred embo~iment, such partitioning is achieved by endovascularly advancing the distal end of a catheter to the desired location with the asc~n~;ng aorta and ~YpAn~ i nq a blocking element on the catheter at said location to inhibit the flow of blood and other fluids past said location. Such partitioning facilitates isolation of the heart, and in particular permits the heart to be stopped while the patient is supported by cardiopulmonary bypass. Once the patient's heart is stopped, a variety of surgical procedures can be performed using percutaneously introduced instruments in a minimally invasive fashion.
The methods of the present invention will be particularly useful for forming coronary artery bypass grafts in a patient suffering from coronary artery disease. The methods will be performed while the treating physician views the region of the heart through the viewing scope, with initial portions of the procedures being performed while normal heart function is maintained. As a first step, the physician will prepare an arterial blood source, typically by harvesting an internal m~ ry artery or other suitable artery.
Conveniently, the lung beneath the internal m~mm~ry WO94/18881 PCT~S94/00305 ~
54: 800-807. Conventional open surgical procedures for performing coronary artery bypass grafting are described in Kirklin and Bar~att Boyes, Cardiac Surgery, John Wiley & Sons, Inc. New York, lg93 (2nd Ed.). Copending application Serial No. 07/730,599, assigned to the assignee of the present application, describes a catheter which is insertable into a patient's arterial system and WO94/18881 21~ PCT~S9~/00305 includes a distal balloon which can be expanded to occlude the A ~ce~ g aorta. The coronary ostia remain unblocked so that the heart and proximal ascending aorta may be isolated while the patient is on cardiopulmonary bypass. This catheter is particularly intended to be used in heart valve replacement procedures.
8~NNARY OF THE 1L~V~1ON
According to the present invention, a method for closed-chest cardiac surgical intervention relies on viewing the region of the heart through a percutaneously positioned viewing scope, such as a thoracoscope. The patient's arterial system will be partitioned during such interventional procedures at a location within the ascending aorta between the brachioc~ph~lic artery and the coronary ostia. In a preferred embo~iment, such partitioning is achieved by endovascularly advancing the distal end of a catheter to the desired location with the asc~n~;ng aorta and ~YpAn~ i nq a blocking element on the catheter at said location to inhibit the flow of blood and other fluids past said location. Such partitioning facilitates isolation of the heart, and in particular permits the heart to be stopped while the patient is supported by cardiopulmonary bypass. Once the patient's heart is stopped, a variety of surgical procedures can be performed using percutaneously introduced instruments in a minimally invasive fashion.
The methods of the present invention will be particularly useful for forming coronary artery bypass grafts in a patient suffering from coronary artery disease. The methods will be performed while the treating physician views the region of the heart through the viewing scope, with initial portions of the procedures being performed while normal heart function is maintained. As a first step, the physician will prepare an arterial blood source, typically by harvesting an internal m~ ry artery or other suitable artery.
Conveniently, the lung beneath the internal m~mm~ry WO94/18881 PCT~S94/00305 ~
3~4 4 artery will be collapsed while the other lung remains ventilated. After the arterial blood source is prepared, cardiopulmonary bypass will be established, the patient's arterial system will be partitioned, and t~le heart stopped, typically by introducing cardioplegic fluid to the isolated heart. A target location on the coronary artery will then be prepared to receive attachment of the arterial blood source, typically by forming an incision at a location downstream from a narrowed region in the artery. The arterial blood source can be connected to the coronary artery by various conventional anastomotic te~hn;ques, such as suturing.
The methods of the present invention provide a minimally-invasive approach for forming coronary artery bypass grafts with an efficacy equal to or greater than conventional open surgical bypass techniques. The methods of the present invention can be adapted to create anastomoses of a variety and type similar to those created by open surgical te~hn;ques, while greatly reducing patient trauma since there is no need to perform a sternotomy. Moreover, the preferred use of an endovascular catheter to partition the aorta and isolate the heart offers a substantial advantage over open surgical t hn;~ues where external clamps are placed on the aorta. External clamps can damage the aorta and may frequently cause the release of emboli from the aortic lumen. Additionally, since the sternum does not need to heal after the procedure, both internal mammary arteries can frequently be used in a single procedure to provide multiple bypass routes. Heretofore, one internal ~mm~ry artery was often left in place to provide blood flow to promote healing of the sternum in many open-surgical procedures.
Fig. 1 is a schematic view showing the placement of four trocar sheaths along the lateral chest on the left side of a patient.
W094/18~81 ~ PCT~S94/OU305 Fig. 2 is a cross-sectional view illustrating the placement of a single trocar sheath between adjacent ribs according to the present invention.
Fig. 3 illustrates the use of an electrosurgical tool introduced through a trocar sheath in order to dissect the left internal mammary artery from the inner thoracic wall to free the artery prior to transection.
Fig. 4 illustrates the use of a clip applier introduced through a trocar sheath in order to seal off portions of the left internal mammary artery prior to transection.
Fig. 5 illustrates transection of the left internal mammary artery to provide an arterial blood source according to the method of the present invention.
Fig. 6 illustrates the use of an endovascular catheter to partition the patient's heart at a location within the asc~;ng aorta according to the method of the present invention. Fig. 6 further illustrates the connection of a cardiopulmonary bypass system to the patient, as well as the optional placement of a reL~oyLade cardioplegia catheter.
Fig. 7 illustrates the preparation of the heart prior to formation of an arteriotomy in the left anterior descen~ing coronary artery which acts as a target location for connection of the internal mammary artery.
Figs. 8-13 illustrate the steps of preparing the coronary artery and suturing the internal mammary artery to an incision formed in the coronary artery in order to complete the desired coronary bypass graft.
These steps are performed in the region of the coronary artery detailed as circle 8-8 in Fig. 7.
Fig. 14 shows the heart after completion of the coronary artery bypass procedure of the present invention, particularly illustrating the bypass from the left internal mammary artery to the distal left anterior des~n~;ng coronary artery.
WO 94/18881 ~ 3 ~ PCTIUS94/00305 ~
DESCRIETION OF 8PECIFIC E~M8ODl~LI55.~8 The methods of the present invention are suitable for performing a variety of surgical cardiac procedures where the heart will be stopped and the patient supported by cardiopulmonary bypass. The procedures will be minimally invasive and be performed using surgical instruments introduced through a plurality of trocar sheaths placed through the patient's chest. A
viewing scope, such as a thoracoscope, will be placed through at least one of the trocar sheaths, and selected surgical instruments will be placed through others of the trocar sheaths and their manipulation viewed by the treating physician using the viewing scope. The methods of the present invention are particularly suitable for forming coronary artery bypass grafts, but will also find use in a variety of other procedures, such as mitral valve repair; mitral valve replacement; thrombectomy of the pulmonary artery, left atrium, or left ventricle;
removal of atrial myxoma; atrial or ventricular septal defect closure; patent foramen ovale closure; tricuspid valve annuloplasty; tricuspid valve replacement;
ventricular aneurysmectomy; thermal and mP~hAn;cal cardiac ablation procedures to correct arrhythmias; and the like.
The method of the present invention for performing a coronary artery bypass graft will now be described in detail. The patient undergoing the procedure is prepared in a conventional manner for cardiac surgery. Additionally, both groins are prepared to permit access to the femoral arteries and veins for cardiopulmonary bypass and introduction of the aortic occlusion catheter, as described in more detail hereinafter. The abdomen will also be prepared in case it is nPc~ccAry to obtain access to an abdo~;nAl artery (for example, the gastroepiploic artery) for use in the bypass procedure. The patient is placed under general anesthesia, and a double-lumen endobronchial tube is ~ WO94/18881 ~ S~ 3~ PCT~S94/00305 inserted for selective ventilation or deflation of either lung.
After the patient has been prepared as described above, a plurality of access trocar sheaths 10, 12, 14, and 16 will be positioned in the lateral chest of the patient P, as illustrated in Fig. 1. The trocar sheaths of Fig. 1 are shown on the left side of the patient and will be used in the creation of an anastomosis between the patient's left internal mammary artery and the left anterior descpn~;ng coronary artery, as will be described in detail hereinafter. Note that it will frequently be desirable to have one or more access trocar sheaths in position on the right side of the patient, particularly to permit the introduction of grasping tools to facilitate repositioning the heart, as described in more detail hereinafter. In addition, it may be desirable to position one or more trocar sheaths in parasternal location(s) as well. Usually, one trocar sheath, for example, trocar sheath 12, will be positioned first, and a thoracoscope will be introduced therethrough. The r~ qi n i n~ trocar sheaths lO, 14, and 16 can then be positioned based on the relative positions of the coronary arteries and other internal body structures which can be viewed after the thoracoscope has been initially placed.
The trocar sheaths lO, 12, 14, and 16 used in the methods of the present invention will generally be shorter than those used for conventional laparoscopic procedures. Typically, trocar sheaths useful for the present invention will have a length in the range from about two to 10 cm, and an internal diameter in the range from two to 15 mm. In addition, the trocar sheaths can be flexible to permit manipulation of tools introduced therethrough. As illustrated in Fig. 2, the trocar sheaths will generally be introduced between adjacent ribs R and will penetrate with their caudal aspect lying just above the superior rib surfaces. Suitable WO94/18881 PCT~S94/00305 ~
3 ~
thoracoscopic trocar sheaths are available from Snowden-Pencer Corp. under the tradename Thora-Port~.
The coronary artery bypass graft procedures of the present invention require that a source of arterial blood be prepared for subsequent bypass connection to the narrowed coronary artery at a location beyond the narrowing. Such arterial blood sources will be primarily of two types. First, existing arteries can be dissected from their natural attachments and transected to provide upstream and downstream free ends. The upstream free end, which is the arterial blood source, will be secured to the coronary artery at a location distal to the narrowing, thus providing the desired bypass blood flow.
Second, artificial arterial shunts may be prepared by attaching a natural or synthetic blood vessel, typically a length obtained from a leg vein, at one end to the proximal asc~n~i~g aorta and at the other end to the target location on a coronary artery. The use of transected arteries is generally preferable since they tend to remain patent for long periods and require only one anastomosis.
The arterial blood source will preferably be the left or right internal mammary artery. It will also be possible to use the gastroepiploic artery in the abdomen. Arre~s to the gastroepiploic artery can be obtained laparoscopically, with the artery being brought into the thorax from the AhAs~;nAl cavity via a window through the diaphragm. When n~cesc~ryl it will be possible to prepare free grafts from the aorta. Such free grafts can be formed from veins or arteries harvested from other locations in a patient's body, or may comprise synthetic graft materials. The free graft may be passed into the thorax through either one of the access trocar sheaths or through the aorta (by punching a hole therethrough). The free grafts thus located will be attached at one end to the proximal Acc~n~ing aorta (to 21~3~
~ WO94/18881 PCT~S94/00305 provide the arterial blood supply) and at the other end to the target location on the coronary artery.
The left internal mammary artery is suitable as an arterial source for target locations on the left anterior de~n~;ng coronary artery, the diagonal coronary artery, the circumflex artery/obtuse marginal artery, and the ramus intermedius coronary artery. The right internal mammary artery is available for connection to all of the same target locations, as well as the right coronary artery and the posterior des~n~ing artery. The gastroepiploic artery and free grafts from the aorta will be available for all target locations.
Referring now to Figs. 3 and 4, an exemplary procedure according to the present invention for transecting the left internal mammary artery IMA will be described. Initially, the left lung is deflated and an electrosurgical tool 30 is used to dissect a length of the internal mammary artery IMA from the inner thoracic wall. The side br~n~-hP~ of the internal mammary artery are sealed. The electrosurgical tool 30 is then intro~c~ through trocar sheath 12 while a grasper 32 or other tool for applying tension on the artery IMA is introduced through trocar sheath 14. The thoracoscope 34 may be positioned through the trocar sheath 16 in order to most advantageously view the operating area at this point in the procedure.
After the internal mammary artery IMA is freed from the thoracic wall, the electrosurgical tool 30 will be replaced with a clip applier 36, with the thoracoscope 34 being moved to trocar sheath 14 and the graspers 32 being moved to trocar sheath lO. The clip applier 36 (Fig. 4) is then used to place one clip 40 upstream and a second clip 42 downstream of a region of the internal m~rm~ry artery IMA to be transected, as illustrated in Fig. 5. Upstream clip 40 will be a temporary occlusion device (e.g., a Fogarty clip, Baxter Corp.) which is later removed from the internal mammary artery IMA to WO94/18881 PCT~S94/0030~ ~
The methods of the present invention provide a minimally-invasive approach for forming coronary artery bypass grafts with an efficacy equal to or greater than conventional open surgical bypass techniques. The methods of the present invention can be adapted to create anastomoses of a variety and type similar to those created by open surgical te~hn;ques, while greatly reducing patient trauma since there is no need to perform a sternotomy. Moreover, the preferred use of an endovascular catheter to partition the aorta and isolate the heart offers a substantial advantage over open surgical t hn;~ues where external clamps are placed on the aorta. External clamps can damage the aorta and may frequently cause the release of emboli from the aortic lumen. Additionally, since the sternum does not need to heal after the procedure, both internal mammary arteries can frequently be used in a single procedure to provide multiple bypass routes. Heretofore, one internal ~mm~ry artery was often left in place to provide blood flow to promote healing of the sternum in many open-surgical procedures.
Fig. 1 is a schematic view showing the placement of four trocar sheaths along the lateral chest on the left side of a patient.
W094/18~81 ~ PCT~S94/OU305 Fig. 2 is a cross-sectional view illustrating the placement of a single trocar sheath between adjacent ribs according to the present invention.
Fig. 3 illustrates the use of an electrosurgical tool introduced through a trocar sheath in order to dissect the left internal mammary artery from the inner thoracic wall to free the artery prior to transection.
Fig. 4 illustrates the use of a clip applier introduced through a trocar sheath in order to seal off portions of the left internal mammary artery prior to transection.
Fig. 5 illustrates transection of the left internal mammary artery to provide an arterial blood source according to the method of the present invention.
Fig. 6 illustrates the use of an endovascular catheter to partition the patient's heart at a location within the asc~;ng aorta according to the method of the present invention. Fig. 6 further illustrates the connection of a cardiopulmonary bypass system to the patient, as well as the optional placement of a reL~oyLade cardioplegia catheter.
Fig. 7 illustrates the preparation of the heart prior to formation of an arteriotomy in the left anterior descen~ing coronary artery which acts as a target location for connection of the internal mammary artery.
Figs. 8-13 illustrate the steps of preparing the coronary artery and suturing the internal mammary artery to an incision formed in the coronary artery in order to complete the desired coronary bypass graft.
These steps are performed in the region of the coronary artery detailed as circle 8-8 in Fig. 7.
Fig. 14 shows the heart after completion of the coronary artery bypass procedure of the present invention, particularly illustrating the bypass from the left internal mammary artery to the distal left anterior des~n~;ng coronary artery.
WO 94/18881 ~ 3 ~ PCTIUS94/00305 ~
DESCRIETION OF 8PECIFIC E~M8ODl~LI55.~8 The methods of the present invention are suitable for performing a variety of surgical cardiac procedures where the heart will be stopped and the patient supported by cardiopulmonary bypass. The procedures will be minimally invasive and be performed using surgical instruments introduced through a plurality of trocar sheaths placed through the patient's chest. A
viewing scope, such as a thoracoscope, will be placed through at least one of the trocar sheaths, and selected surgical instruments will be placed through others of the trocar sheaths and their manipulation viewed by the treating physician using the viewing scope. The methods of the present invention are particularly suitable for forming coronary artery bypass grafts, but will also find use in a variety of other procedures, such as mitral valve repair; mitral valve replacement; thrombectomy of the pulmonary artery, left atrium, or left ventricle;
removal of atrial myxoma; atrial or ventricular septal defect closure; patent foramen ovale closure; tricuspid valve annuloplasty; tricuspid valve replacement;
ventricular aneurysmectomy; thermal and mP~hAn;cal cardiac ablation procedures to correct arrhythmias; and the like.
The method of the present invention for performing a coronary artery bypass graft will now be described in detail. The patient undergoing the procedure is prepared in a conventional manner for cardiac surgery. Additionally, both groins are prepared to permit access to the femoral arteries and veins for cardiopulmonary bypass and introduction of the aortic occlusion catheter, as described in more detail hereinafter. The abdomen will also be prepared in case it is nPc~ccAry to obtain access to an abdo~;nAl artery (for example, the gastroepiploic artery) for use in the bypass procedure. The patient is placed under general anesthesia, and a double-lumen endobronchial tube is ~ WO94/18881 ~ S~ 3~ PCT~S94/00305 inserted for selective ventilation or deflation of either lung.
After the patient has been prepared as described above, a plurality of access trocar sheaths 10, 12, 14, and 16 will be positioned in the lateral chest of the patient P, as illustrated in Fig. 1. The trocar sheaths of Fig. 1 are shown on the left side of the patient and will be used in the creation of an anastomosis between the patient's left internal mammary artery and the left anterior descpn~;ng coronary artery, as will be described in detail hereinafter. Note that it will frequently be desirable to have one or more access trocar sheaths in position on the right side of the patient, particularly to permit the introduction of grasping tools to facilitate repositioning the heart, as described in more detail hereinafter. In addition, it may be desirable to position one or more trocar sheaths in parasternal location(s) as well. Usually, one trocar sheath, for example, trocar sheath 12, will be positioned first, and a thoracoscope will be introduced therethrough. The r~ qi n i n~ trocar sheaths lO, 14, and 16 can then be positioned based on the relative positions of the coronary arteries and other internal body structures which can be viewed after the thoracoscope has been initially placed.
The trocar sheaths lO, 12, 14, and 16 used in the methods of the present invention will generally be shorter than those used for conventional laparoscopic procedures. Typically, trocar sheaths useful for the present invention will have a length in the range from about two to 10 cm, and an internal diameter in the range from two to 15 mm. In addition, the trocar sheaths can be flexible to permit manipulation of tools introduced therethrough. As illustrated in Fig. 2, the trocar sheaths will generally be introduced between adjacent ribs R and will penetrate with their caudal aspect lying just above the superior rib surfaces. Suitable WO94/18881 PCT~S94/00305 ~
3 ~
thoracoscopic trocar sheaths are available from Snowden-Pencer Corp. under the tradename Thora-Port~.
The coronary artery bypass graft procedures of the present invention require that a source of arterial blood be prepared for subsequent bypass connection to the narrowed coronary artery at a location beyond the narrowing. Such arterial blood sources will be primarily of two types. First, existing arteries can be dissected from their natural attachments and transected to provide upstream and downstream free ends. The upstream free end, which is the arterial blood source, will be secured to the coronary artery at a location distal to the narrowing, thus providing the desired bypass blood flow.
Second, artificial arterial shunts may be prepared by attaching a natural or synthetic blood vessel, typically a length obtained from a leg vein, at one end to the proximal asc~n~i~g aorta and at the other end to the target location on a coronary artery. The use of transected arteries is generally preferable since they tend to remain patent for long periods and require only one anastomosis.
The arterial blood source will preferably be the left or right internal mammary artery. It will also be possible to use the gastroepiploic artery in the abdomen. Arre~s to the gastroepiploic artery can be obtained laparoscopically, with the artery being brought into the thorax from the AhAs~;nAl cavity via a window through the diaphragm. When n~cesc~ryl it will be possible to prepare free grafts from the aorta. Such free grafts can be formed from veins or arteries harvested from other locations in a patient's body, or may comprise synthetic graft materials. The free graft may be passed into the thorax through either one of the access trocar sheaths or through the aorta (by punching a hole therethrough). The free grafts thus located will be attached at one end to the proximal Acc~n~ing aorta (to 21~3~
~ WO94/18881 PCT~S94/00305 provide the arterial blood supply) and at the other end to the target location on the coronary artery.
The left internal mammary artery is suitable as an arterial source for target locations on the left anterior de~n~;ng coronary artery, the diagonal coronary artery, the circumflex artery/obtuse marginal artery, and the ramus intermedius coronary artery. The right internal mammary artery is available for connection to all of the same target locations, as well as the right coronary artery and the posterior des~n~ing artery. The gastroepiploic artery and free grafts from the aorta will be available for all target locations.
Referring now to Figs. 3 and 4, an exemplary procedure according to the present invention for transecting the left internal mammary artery IMA will be described. Initially, the left lung is deflated and an electrosurgical tool 30 is used to dissect a length of the internal mammary artery IMA from the inner thoracic wall. The side br~n~-hP~ of the internal mammary artery are sealed. The electrosurgical tool 30 is then intro~c~ through trocar sheath 12 while a grasper 32 or other tool for applying tension on the artery IMA is introduced through trocar sheath 14. The thoracoscope 34 may be positioned through the trocar sheath 16 in order to most advantageously view the operating area at this point in the procedure.
After the internal mammary artery IMA is freed from the thoracic wall, the electrosurgical tool 30 will be replaced with a clip applier 36, with the thoracoscope 34 being moved to trocar sheath 14 and the graspers 32 being moved to trocar sheath lO. The clip applier 36 (Fig. 4) is then used to place one clip 40 upstream and a second clip 42 downstream of a region of the internal m~rm~ry artery IMA to be transected, as illustrated in Fig. 5. Upstream clip 40 will be a temporary occlusion device (e.g., a Fogarty clip, Baxter Corp.) which is later removed from the internal mammary artery IMA to WO94/18881 PCT~S94/0030~ ~
4~
establish bypass flow. Downstream clip 42 will be permanently left in place. After the clips 40 and 42 are applied, a cutting tool 44 can be introduced through the same trocar sheath 12 which had received the clip applying tool, and the cutting tool used to cut the artery in a conventional manner. Note that it will be desirable to cut the artery along a diagonal transverse line in order to provide an oval-shaped distal end, as best seen in Figs. 7 and 9. If necessary, the original cut can be further trimmed to provide a free upstream end suitable for connection to the narrowed coronary artery at a location distal to the narrowed segment. Usually, excess fat will be dissected from the distal 1-2 cm of the severed artery. The ~;-C~ction can be carried out either within or outside of the thorax, with outside procedures performed by drawing the upstream free end of the artery out through a trocar sheath temporarily.
A particular advantage of the method of the present invention is that both the left and the right internal ~ ry arteries can be used for bypass in a single procedure. Moreover, each internal mammary artery can be used to form more than one bypass anastomosis including both side-to-side anasto~A-c and an end-to-side anastomosis. Either internal mammary artery may be used for rev~c~llArizations on either side of the heart.
After the internal mammary artery IMA has been transected and prepared, it is n~C~csAry to place the patient on cardiopulmonary bypass and to induce cardioplegia (i.e., stop cardiac contraction) prior to connecting the arterial graft to the coronary artery.
Cardioplegia can be induced by introducing certain chemicals (usually potassium-cont~in;ng solutions) into the interior of the myocardium and requires that the patient's arterial system be partitioned to isolate the heart and proximal asc~n~i ng aorta from the r~;n~er of the patient's vascular system. The isolated heart and ascending aorta can then be selectively exposed to a cold ~ WO94/18881 PCT~S94/00305 .. . .
solution that contains a high concentration of cardioplegic chemicals.
Referring to Fig. 6, the arterial system may be partitioned using an aortic occlusion balloon catheter 50 which is positioned in the asc~n~;ng aorta 52 to separate the left ventricle 54 and proximal portion of the ascPn~ing aorta from the rest of the patient's arterial system. A cardiopulmonary bypass system 56 removes venous blood from the femoral vein 58 using a conventional blood withdrawal catheter 60. The bypass system 56 removes carbon dioxide from the blood, oxygenates the blood, and returns the oxygenated blood to the patient's femoral artery 62 through a conventional return catheter 64. The bypass system 56 will operate at a sufficient pressure to drive the circulation of the blood through the patient's arterial system except for that portion which is blocked by the aortic occlusion catheter.
The aortic occlusion catheter 50 is preferably endovascularly introduced over a conventional guidewire to the asc~n~;ng aorta through the left femoral artery 66 which is entered either percutaneously or through an open cut down 67 of the groin. A proximal hub 68 is located on the proximal end of the occlusion catheter 50 and includes a balloon inflation means, such as syringe 70, a main access port 72 to permit the introduction of instruments, irrigation fluid, and the like. Optionally, a third introduction port 74 may be provided to recirculate a portion of the venous blood from catheter 60. The provision of access ports in the aortic occlusion catheter 50 is optional. It is n~C~cc~ry only that the catheter 50 be able to position a blocking element, such as the inflatable balloon, at the proper location within the asc~n~ing aorta. One or more access ports and lumens, however, may be an advantage in a variety of circumstances. For example, the catheter 50 with an access lumen would permit anterograde WO94/18881 PCT~S94/00305 ~
3 ~ _ a~; n i ~tration of cardioplegic fluid and would also permit anterograde venting of the left ventricle. Such a lumen could also provide access by acting as an anchored guiding catheter for a variety of other conventional diagnostic and interventional catheters, such as angiography, angioplasty, atherectomy, and similar vascular catheters. The construction of suitable aortic occlusion catheters having such access ports and lumens is described in detail in cop~n~ i ng application Serial No. 07/730,559, filed on July 16, l99l, the full disclosure of which is incorporated herein by reference.
As just described, the aortic occlusion balloon catheter 50 will preferably be introduced percutaneously or through an open cutdown of the femoral artery. It may also be possible to introduce the catheter 50 through a trocar sheath placed in the chest, where the catheter is then passed through an aortic arteriotomy in the descending aorta and advanced through the lumen to the location in the ~ Cc~n~ i ng aorta, as described above.
Introduction via an aortic arteriotomy, however, will generally be less preferred since it is t~chnically more difficult than introduction through the femoral artery.
Such introduction, however, may be indicated in cases where the femoral arteries are inaccessible and atherosclerosis of the asr~nAing aorta makes use of an external clamp hazardous (because of possible generation of emboli).
In some cases, the patient's vascular system might be partitioned using an external clamp located on the asc~n~i~g aorta between the brachiocerh~lic artery and the coronary ostia. The external clamp would be similar to those employed in open surgical procedures, except that it would be suitable for placement through a trocar sheath under thoracoscopic guidance. Use of an external clamp, however, is generally less preferred since it risks trauma to the aorta, release of emboli from the diseased aortic lumen, and the like.
~ W094/18881 ~ 3~4 PCT~Sg4/on30s In addition to provisions for cardiopulmonary bypass and for arterial system partition, the patient will be prepared to receive the introduction of a fluid contA; n; ng cardioplegic agents to the myocardium. Such agents may be delivered directly into the aortic root and coronary ostia in an anterograde manner employing the aortic occlusion catheter for such delivery. The blocking element of the aortic occlusion catheter prevents ~c~p~ of cardioplegic fluid into the remainder of the arterial circulation.
Alternatively, the cardioplegic agents can be delivered in a reLLoyLade fashion using a coronary sinus catheter 80 which is introduced in a conventional manner through the patient's right internal jugular vein 79, and includes a balloon at the distal end of the catheter extending into the coronary sinus 82. A pulmonary artery venting catheter 84 may also be introA1lc~ through the right internal jugular vein 79 and eventually into the pulmonary trunk 86, as illustrated. The pulmonary venting catheter 84 may include an inflatable balloon (not illustrated) which can be used if n~C~c~A~y to occlude the pulmonary trunk 86 as well as an inner lumen which can vent fluid from the p1llr~nA~y trunk and thereby decompress the left ventricle 54 as necessary during the procedure. Use of the aortic occlusion catheter 50, the coronary sinus catheter 80, and the pulmonary venting catheter 84 is described more fully in copending application serial number 07/730,559, the disclosure of which has previously been incorporated herein by reference.
Cardiopulmonary bypass and cardioplegia are then initiated as follows. First, the cardiopulmonary bypass system 56 is activated, followed by inflation of the blocking balloon on the aortic occlusion catheter.
The blocking balloon will be positioned between the brachiocephalic artery and the coronary ostia, neither of which will be occluded. In this way, the patient's left WO94/18881 PCT~S94/00305 1.
ventricle and proximal ~sc~n~ ing aorta are isolated from the distal asc~n~;ng aorta and the rP~;n~er of circulation. Cardioplegic fluid may then be perfused, in either an anterograde or retrograde fashion, into the coronary circulation in order to arrest and cool the heart, while the r~; n~Pr of the arterial system is perfused with blood, coming from the cardiopulmonary bypass system. Preferably, the temperature of the heart will be lowered to as low as 5C by perfusing the heart with cold liquid cardioplegic fluid and optionally by topical cooling. Heart temperature may be monitored using a myocardia probe which is introAllc~ either through one of the trocar sheaths or together with one of the coronary catheters. Such topical cooling may be achieved by infusing cold saline over the heart surface within the pericardium or by covering the heart with a cooling jacket, such as a Dailey jacket available from Medtronic, St. Paul, M; nnpcota.
After cardiopulmonary bypass has been established, both lungs will be deflated in order to mA~;m;7e visualization of the cardiac region during the r~; n~r of the method. The left ventricle may be vented, if n~cecc~ry~ using the pulmonary artery vent catheter 84 or an aortic root vent catheter (not illustrated) introduced through an A~C~C~ lumen of the aortic occlusion catheter 50. Alternatively, it may be possible to vent either the pulmonary artery, left atrium, or left ventricle using a catheter pA~r^~ into the thorax through a trocar sheath, where the catheter is then passed directly through the wall of the artery, atrium, or ventricle. Finally, it is possible to vent the left ventricle using only negative pressure applied to the proximal end of the aortic occlusion catheter, which thus acts as an aortic root vent.
As an alternative to the use of chemical cardioplegic fluids, the patient's heart could be "stopped" for purposes of the present procedures by WO94/18881 ~ PCT~S94/00305 electrically inducing fibrillation. The necessary electrodes could be introA~lc~ through selected trocar sheaths, or could be applied externally on the patient's chest. See, A;k;nc (1984) J. Thorac. Cardiovasc. Surg.
88:174, for a description of such t~chni ques. Use of chemical cardioplegia to arrest the heart will generally be preferred, since the cooled, arrested heart will have a much lower oxygen re~uirement than the fibrillating heart, which r~ c~fi the likelihood of intraoperative injury to the heart.
The patient is now ready to have the diseased coronary artery or arteries prepared for anastomoses.
Initially, a pericardiotomy is performed to provide access to the coronary arteries. The pericardiotomy can be performed using suitable instruments, such as electrosurgical instruments, introduced through the lateral chest trocar sheaths (Fig. l) while viewing the region through the thoracoscope. The pericardium can be incised and spread open for access, or portions of the pericardium can be excised and removed from the thoracic cavity.
Referring now to Fig. 7, the ~ecompressed heart H will now be repositioned using suitable instruments in order to better expose the coronary artery which is the target for anastomosis. Suitable tools include hooks, suction catheters, grasping rods, pushing rods, and the like. Gravity can also be used to help position the heart if the patient can be turned appropriately. As illustrated in Fig. 7, a pair of graspers 9O may be used to secure opposite sides of the heart and permit turning of the heart as desired. Optionally, additional trocar sheaths may be introduced at other sites of thoracic access. For example, one or more parasternal punctures, one or more punctures in the midclavicular line, and/or a subxyphoid puncture may be introduced.
As illustrated, the left anterior descending coronary artery LAD is first pulled upward from the WO94/18881 PCT~S94/00305 ~ 16 surface of the heart H and stretched using a pair of elastic members 92 which are introduced through appropriately positioned trocar sheaths. The elastic members 92 place axial tension on the region of the coronary artery LAD which is to be prepared for anastomosis. In addition, they provide a bloodless lumen, permitting excellent visualization.
Referring now to Fig. 8, an incision ~5 is made in the wall of the coronary artery LAD, where the incision has dimensions selected to match those of the upstream free end of the internal mammary artery graft.
The incision 95 is made by first piercing the arterial wall using the tip of a scalpel (not illustrated).
Scissors 96 are then introduced through the penetration and used to axially extend the penetration, as illustrated at 97 in Fig. 9.
The internal mammary artery IMA can be joined to the exten~e~ incision 97 in the coronary artery LAD by a variety of conventional t~ch~; ~ues, including suturing, laser welding, microstapling, and the like. It will be preferred to use conventional suturing t~ch~; ques as illustrated in Figs. 9-13. A length of suture 98 has needles lOO at either end, which are manipulated using forceps 102 to join the free upstream end lOl of the internal mammary artery IMA graft to the opening created by the incision 97 in the coronary artery LAD.
After the suturing is complete, the internal mammary artery IMA will be joined to the coronary artery LAD as illustrated in Fig. 14. The temporary clip 40 will then be removed to permit blood flow from the internal mammary artery IMA into the coronary artery, thus bypassing the previous blockage in the coronary artery. The downstream free end of the internal mammary artery IMA will remain clipped, as described above.
Following completion of the coronary anastomoses, all heart manipulating devices will be removed from the patient, and the heart will be permitted ~ W094/188~1 ~L~4~ PCT~S94/00305 to return to its natural orientation. The aortic occlusion catheter 50 will be deflated. Both lungs will be ventilated, and the coronary arteries will be perfused with blood to initiate cardiac contractions in a conventional manner. If necessary, the heart will be defibrillated to correct its rhythm using electrodes placed either on the heart surface via trocar sheaths or on the patient's body surface. The cardiopulmonary bypass will be gradually re~lre~ and stopped. The aortic occlusion catheter will be removed, and the bypass catheters withdrawn. The groin penetrations will be repaired as n~C~ ry, all rem~;~; nq trocar sheaths will be removed, and all thoracic punctures will be sealed in a conventional manner. Finally, the patient will be recovered from anesthesia.
Although the foregoing invention has been described in some detail by way of illustration and example, for purposes of clarity of underst~n~;~g, it will be obvious that certain changes and modifications may be practiced within the scope of the appended claims.
establish bypass flow. Downstream clip 42 will be permanently left in place. After the clips 40 and 42 are applied, a cutting tool 44 can be introduced through the same trocar sheath 12 which had received the clip applying tool, and the cutting tool used to cut the artery in a conventional manner. Note that it will be desirable to cut the artery along a diagonal transverse line in order to provide an oval-shaped distal end, as best seen in Figs. 7 and 9. If necessary, the original cut can be further trimmed to provide a free upstream end suitable for connection to the narrowed coronary artery at a location distal to the narrowed segment. Usually, excess fat will be dissected from the distal 1-2 cm of the severed artery. The ~;-C~ction can be carried out either within or outside of the thorax, with outside procedures performed by drawing the upstream free end of the artery out through a trocar sheath temporarily.
A particular advantage of the method of the present invention is that both the left and the right internal ~ ry arteries can be used for bypass in a single procedure. Moreover, each internal mammary artery can be used to form more than one bypass anastomosis including both side-to-side anasto~A-c and an end-to-side anastomosis. Either internal mammary artery may be used for rev~c~llArizations on either side of the heart.
After the internal mammary artery IMA has been transected and prepared, it is n~C~csAry to place the patient on cardiopulmonary bypass and to induce cardioplegia (i.e., stop cardiac contraction) prior to connecting the arterial graft to the coronary artery.
Cardioplegia can be induced by introducing certain chemicals (usually potassium-cont~in;ng solutions) into the interior of the myocardium and requires that the patient's arterial system be partitioned to isolate the heart and proximal asc~n~i ng aorta from the r~;n~er of the patient's vascular system. The isolated heart and ascending aorta can then be selectively exposed to a cold ~ WO94/18881 PCT~S94/00305 .. . .
solution that contains a high concentration of cardioplegic chemicals.
Referring to Fig. 6, the arterial system may be partitioned using an aortic occlusion balloon catheter 50 which is positioned in the asc~n~;ng aorta 52 to separate the left ventricle 54 and proximal portion of the ascPn~ing aorta from the rest of the patient's arterial system. A cardiopulmonary bypass system 56 removes venous blood from the femoral vein 58 using a conventional blood withdrawal catheter 60. The bypass system 56 removes carbon dioxide from the blood, oxygenates the blood, and returns the oxygenated blood to the patient's femoral artery 62 through a conventional return catheter 64. The bypass system 56 will operate at a sufficient pressure to drive the circulation of the blood through the patient's arterial system except for that portion which is blocked by the aortic occlusion catheter.
The aortic occlusion catheter 50 is preferably endovascularly introduced over a conventional guidewire to the asc~n~;ng aorta through the left femoral artery 66 which is entered either percutaneously or through an open cut down 67 of the groin. A proximal hub 68 is located on the proximal end of the occlusion catheter 50 and includes a balloon inflation means, such as syringe 70, a main access port 72 to permit the introduction of instruments, irrigation fluid, and the like. Optionally, a third introduction port 74 may be provided to recirculate a portion of the venous blood from catheter 60. The provision of access ports in the aortic occlusion catheter 50 is optional. It is n~C~cc~ry only that the catheter 50 be able to position a blocking element, such as the inflatable balloon, at the proper location within the asc~n~ing aorta. One or more access ports and lumens, however, may be an advantage in a variety of circumstances. For example, the catheter 50 with an access lumen would permit anterograde WO94/18881 PCT~S94/00305 ~
3 ~ _ a~; n i ~tration of cardioplegic fluid and would also permit anterograde venting of the left ventricle. Such a lumen could also provide access by acting as an anchored guiding catheter for a variety of other conventional diagnostic and interventional catheters, such as angiography, angioplasty, atherectomy, and similar vascular catheters. The construction of suitable aortic occlusion catheters having such access ports and lumens is described in detail in cop~n~ i ng application Serial No. 07/730,559, filed on July 16, l99l, the full disclosure of which is incorporated herein by reference.
As just described, the aortic occlusion balloon catheter 50 will preferably be introduced percutaneously or through an open cutdown of the femoral artery. It may also be possible to introduce the catheter 50 through a trocar sheath placed in the chest, where the catheter is then passed through an aortic arteriotomy in the descending aorta and advanced through the lumen to the location in the ~ Cc~n~ i ng aorta, as described above.
Introduction via an aortic arteriotomy, however, will generally be less preferred since it is t~chnically more difficult than introduction through the femoral artery.
Such introduction, however, may be indicated in cases where the femoral arteries are inaccessible and atherosclerosis of the asr~nAing aorta makes use of an external clamp hazardous (because of possible generation of emboli).
In some cases, the patient's vascular system might be partitioned using an external clamp located on the asc~n~i~g aorta between the brachiocerh~lic artery and the coronary ostia. The external clamp would be similar to those employed in open surgical procedures, except that it would be suitable for placement through a trocar sheath under thoracoscopic guidance. Use of an external clamp, however, is generally less preferred since it risks trauma to the aorta, release of emboli from the diseased aortic lumen, and the like.
~ W094/18881 ~ 3~4 PCT~Sg4/on30s In addition to provisions for cardiopulmonary bypass and for arterial system partition, the patient will be prepared to receive the introduction of a fluid contA; n; ng cardioplegic agents to the myocardium. Such agents may be delivered directly into the aortic root and coronary ostia in an anterograde manner employing the aortic occlusion catheter for such delivery. The blocking element of the aortic occlusion catheter prevents ~c~p~ of cardioplegic fluid into the remainder of the arterial circulation.
Alternatively, the cardioplegic agents can be delivered in a reLLoyLade fashion using a coronary sinus catheter 80 which is introduced in a conventional manner through the patient's right internal jugular vein 79, and includes a balloon at the distal end of the catheter extending into the coronary sinus 82. A pulmonary artery venting catheter 84 may also be introA1lc~ through the right internal jugular vein 79 and eventually into the pulmonary trunk 86, as illustrated. The pulmonary venting catheter 84 may include an inflatable balloon (not illustrated) which can be used if n~C~c~A~y to occlude the pulmonary trunk 86 as well as an inner lumen which can vent fluid from the p1llr~nA~y trunk and thereby decompress the left ventricle 54 as necessary during the procedure. Use of the aortic occlusion catheter 50, the coronary sinus catheter 80, and the pulmonary venting catheter 84 is described more fully in copending application serial number 07/730,559, the disclosure of which has previously been incorporated herein by reference.
Cardiopulmonary bypass and cardioplegia are then initiated as follows. First, the cardiopulmonary bypass system 56 is activated, followed by inflation of the blocking balloon on the aortic occlusion catheter.
The blocking balloon will be positioned between the brachiocephalic artery and the coronary ostia, neither of which will be occluded. In this way, the patient's left WO94/18881 PCT~S94/00305 1.
ventricle and proximal ~sc~n~ ing aorta are isolated from the distal asc~n~;ng aorta and the rP~;n~er of circulation. Cardioplegic fluid may then be perfused, in either an anterograde or retrograde fashion, into the coronary circulation in order to arrest and cool the heart, while the r~; n~Pr of the arterial system is perfused with blood, coming from the cardiopulmonary bypass system. Preferably, the temperature of the heart will be lowered to as low as 5C by perfusing the heart with cold liquid cardioplegic fluid and optionally by topical cooling. Heart temperature may be monitored using a myocardia probe which is introAllc~ either through one of the trocar sheaths or together with one of the coronary catheters. Such topical cooling may be achieved by infusing cold saline over the heart surface within the pericardium or by covering the heart with a cooling jacket, such as a Dailey jacket available from Medtronic, St. Paul, M; nnpcota.
After cardiopulmonary bypass has been established, both lungs will be deflated in order to mA~;m;7e visualization of the cardiac region during the r~; n~r of the method. The left ventricle may be vented, if n~cecc~ry~ using the pulmonary artery vent catheter 84 or an aortic root vent catheter (not illustrated) introduced through an A~C~C~ lumen of the aortic occlusion catheter 50. Alternatively, it may be possible to vent either the pulmonary artery, left atrium, or left ventricle using a catheter pA~r^~ into the thorax through a trocar sheath, where the catheter is then passed directly through the wall of the artery, atrium, or ventricle. Finally, it is possible to vent the left ventricle using only negative pressure applied to the proximal end of the aortic occlusion catheter, which thus acts as an aortic root vent.
As an alternative to the use of chemical cardioplegic fluids, the patient's heart could be "stopped" for purposes of the present procedures by WO94/18881 ~ PCT~S94/00305 electrically inducing fibrillation. The necessary electrodes could be introA~lc~ through selected trocar sheaths, or could be applied externally on the patient's chest. See, A;k;nc (1984) J. Thorac. Cardiovasc. Surg.
88:174, for a description of such t~chni ques. Use of chemical cardioplegia to arrest the heart will generally be preferred, since the cooled, arrested heart will have a much lower oxygen re~uirement than the fibrillating heart, which r~ c~fi the likelihood of intraoperative injury to the heart.
The patient is now ready to have the diseased coronary artery or arteries prepared for anastomoses.
Initially, a pericardiotomy is performed to provide access to the coronary arteries. The pericardiotomy can be performed using suitable instruments, such as electrosurgical instruments, introduced through the lateral chest trocar sheaths (Fig. l) while viewing the region through the thoracoscope. The pericardium can be incised and spread open for access, or portions of the pericardium can be excised and removed from the thoracic cavity.
Referring now to Fig. 7, the ~ecompressed heart H will now be repositioned using suitable instruments in order to better expose the coronary artery which is the target for anastomosis. Suitable tools include hooks, suction catheters, grasping rods, pushing rods, and the like. Gravity can also be used to help position the heart if the patient can be turned appropriately. As illustrated in Fig. 7, a pair of graspers 9O may be used to secure opposite sides of the heart and permit turning of the heart as desired. Optionally, additional trocar sheaths may be introduced at other sites of thoracic access. For example, one or more parasternal punctures, one or more punctures in the midclavicular line, and/or a subxyphoid puncture may be introduced.
As illustrated, the left anterior descending coronary artery LAD is first pulled upward from the WO94/18881 PCT~S94/00305 ~ 16 surface of the heart H and stretched using a pair of elastic members 92 which are introduced through appropriately positioned trocar sheaths. The elastic members 92 place axial tension on the region of the coronary artery LAD which is to be prepared for anastomosis. In addition, they provide a bloodless lumen, permitting excellent visualization.
Referring now to Fig. 8, an incision ~5 is made in the wall of the coronary artery LAD, where the incision has dimensions selected to match those of the upstream free end of the internal mammary artery graft.
The incision 95 is made by first piercing the arterial wall using the tip of a scalpel (not illustrated).
Scissors 96 are then introduced through the penetration and used to axially extend the penetration, as illustrated at 97 in Fig. 9.
The internal mammary artery IMA can be joined to the exten~e~ incision 97 in the coronary artery LAD by a variety of conventional t~ch~; ~ues, including suturing, laser welding, microstapling, and the like. It will be preferred to use conventional suturing t~ch~; ques as illustrated in Figs. 9-13. A length of suture 98 has needles lOO at either end, which are manipulated using forceps 102 to join the free upstream end lOl of the internal mammary artery IMA graft to the opening created by the incision 97 in the coronary artery LAD.
After the suturing is complete, the internal mammary artery IMA will be joined to the coronary artery LAD as illustrated in Fig. 14. The temporary clip 40 will then be removed to permit blood flow from the internal mammary artery IMA into the coronary artery, thus bypassing the previous blockage in the coronary artery. The downstream free end of the internal mammary artery IMA will remain clipped, as described above.
Following completion of the coronary anastomoses, all heart manipulating devices will be removed from the patient, and the heart will be permitted ~ W094/188~1 ~L~4~ PCT~S94/00305 to return to its natural orientation. The aortic occlusion catheter 50 will be deflated. Both lungs will be ventilated, and the coronary arteries will be perfused with blood to initiate cardiac contractions in a conventional manner. If necessary, the heart will be defibrillated to correct its rhythm using electrodes placed either on the heart surface via trocar sheaths or on the patient's body surface. The cardiopulmonary bypass will be gradually re~lre~ and stopped. The aortic occlusion catheter will be removed, and the bypass catheters withdrawn. The groin penetrations will be repaired as n~C~ ry, all rem~;~; nq trocar sheaths will be removed, and all thoracic punctures will be sealed in a conventional manner. Finally, the patient will be recovered from anesthesia.
Although the foregoing invention has been described in some detail by way of illustration and example, for purposes of clarity of underst~n~;~g, it will be obvious that certain changes and modifications may be practiced within the scope of the appended claims.
Claims (38)
1. A method for closed-chest cardiac surgical intervention, said method comprising:
forming at least one percutaneous penetration in the patient's chest;
viewing the region of the heart through a viewing scope disposed through a percutaneous penetration;
partitioning the patient's arterial system at a location within the ascending aorta between the brachiocephalic artery and the coronary ostia;
establishing cardiopulmonary bypass;
stopping heart contraction; and performing a surgical procedure on the stopped heart using tools introduced through a percutaneous penetration while viewing the heart through the viewing scope.
forming at least one percutaneous penetration in the patient's chest;
viewing the region of the heart through a viewing scope disposed through a percutaneous penetration;
partitioning the patient's arterial system at a location within the ascending aorta between the brachiocephalic artery and the coronary ostia;
establishing cardiopulmonary bypass;
stopping heart contraction; and performing a surgical procedure on the stopped heart using tools introduced through a percutaneous penetration while viewing the heart through the viewing scope.
2. A method as in claim 1, wherein the viewing scope is introduced through a trocar sheath disposed in a percutaneous penetration.
3. A method as in claim 1, wherein the arterial system is partitioned by endovascularly advancing a distal end of a catheter to the location within the ascending aorta, and expanding a blocking element on the catheter at said location to inhibit the flow of blood and other fluids past said location.
4. A method as in claim 1, wherein cardiopulmonary bypass is established from the femoral vein to the femoral artery.
5. A method as in claim 3, wherein heart function is stopped by introducing a cardioplegic agent to the heart or by inducing ventricular fibrillation.
6. A method for forming a coronary artery bypass graft in a patient, said method comprising:
forming at least one percutaneous penetration in the patient's chest;
viewing the region of the heart through a viewing scope disposed through a percutaneous penetration;
forming an arterial blood source;
endovascularly partitioning the patient's arterial system at a location within the ascending aorta between the brachiocephalic artery and the coronary ostia;
establishing cardiopulmonary bypass;
stopping heart contraction; and connecting the arterial blood source to a location in a coronary artery downstream from an occlusion using tools introduced through a percutaneous penetration while viewing the region of the stopped heart through the viewing scope.
forming at least one percutaneous penetration in the patient's chest;
viewing the region of the heart through a viewing scope disposed through a percutaneous penetration;
forming an arterial blood source;
endovascularly partitioning the patient's arterial system at a location within the ascending aorta between the brachiocephalic artery and the coronary ostia;
establishing cardiopulmonary bypass;
stopping heart contraction; and connecting the arterial blood source to a location in a coronary artery downstream from an occlusion using tools introduced through a percutaneous penetration while viewing the region of the stopped heart through the viewing scope.
7. A method as in claim 6, wherein the viewing scope is introduced through a trocar sheath disposed in a percutaneous penetration.
8. A method as in claim 6, wherein the arterial blood source is formed by transecting an artery.
9. A method as in claim 8, wherein the transected artery is a mammary artery.
10. A method as in claim 6, wherein the arterial blood source is formed by grafting a natural or synthetic blood vessel to the aorta.
11. A method as in claim 6, wherein the arterial system is partitioned by endovascularly advancing a distal end of a catheter to the location within the ascending aorta, and expanding a blocking element on the catheter at said location to inhibit the flow of blood and other fluids past said location.
12. A method as in claim 6, wherein cardiopulmonary bypass is established from the femoral vein to the femoral artery.
13. A method as in claim 11, wherein the heart is stopped by anterograde introduction of cardioplegic fluid into the coronary arteries through the catheter.
14. A method as in claim 6, wherein the arterial blood source is connected to an incision formed in the coronary artery while the heart remains stopped.
15. A method for forming an anastomosis between a mammary artery and a coronary artery of a patient, said method comprising:
positioning at least one trocar sheath through the patient's chest;
introducing a viewing scope through the trocar sheath to view the region around the heart;
collapsing a lung beneath the mammary artery while ventilating the contralateral lung;
transecting the mammary artery using a tool introduced through a trocar sheath while viewing the artery using the viewing scope;
endovascularly partitioning the patient's arterial system at a location within the ascending aorta between the brachiocephalic artery and the coronary ostia;
establishing cardiopulmonary bypass;
stopping heart contraction;
collapsing both lungs;
forming an incision in the coronary artery using a cutting tool introduced through a trocar sheath while viewing the artery using the viewing scope while the heart is stopped; and connecting the transected internal mammary artery to the incision in the coronary artery using a tool introduced through one of the trocar sheaths while viewing the arteries using the viewing scope while the heart is stopped.
positioning at least one trocar sheath through the patient's chest;
introducing a viewing scope through the trocar sheath to view the region around the heart;
collapsing a lung beneath the mammary artery while ventilating the contralateral lung;
transecting the mammary artery using a tool introduced through a trocar sheath while viewing the artery using the viewing scope;
endovascularly partitioning the patient's arterial system at a location within the ascending aorta between the brachiocephalic artery and the coronary ostia;
establishing cardiopulmonary bypass;
stopping heart contraction;
collapsing both lungs;
forming an incision in the coronary artery using a cutting tool introduced through a trocar sheath while viewing the artery using the viewing scope while the heart is stopped; and connecting the transected internal mammary artery to the incision in the coronary artery using a tool introduced through one of the trocar sheaths while viewing the arteries using the viewing scope while the heart is stopped.
16. A method as in claim 15, wherein at least three trocar sheaths are positioned on the lateral chest and between adjacent ribs.
17. A method as in claim 15, wherein the internal mammary artery is transected using an electrosurgical cutting tool to dissect the artery from the thoracic wall and a cutting tool to sever the proper length of the artery.
18. A method as in claim 15, wherein the arterial system is partitioned by endovascularly advancing a distal end of a catheter to the location within the ascending aorta, and expanding a blocking element on the catheter at said location to inhibit the flow of blood and other fluids past said location.
19. A method as in claim 15, wherein cardiopulmonary bypass is established from the femoral vein to the femoral artery.
20. A method as in claim 18, wherein the heart is stopped by the anterograde introduction of cardioplegic fluid through the catheter.
21. A method as in claim 15, wherein the incision in the coronary artery is formed using a scalpel.
22. A method as in claim 15, wherein the arteries are connected using suture.
23. A method as in claim 18, wherein the left ventricle is vented by applying a negative pressure through the catheter.
24. A method as in claim 15, wherein the stopped heart is repositioned to better expose the region of the coronary artery which is the target for the incision.
25. A method as in claim 24, wherein the stopped heart is repositioned using at least two graspers positioned on opposite sides of the heart.
26. An improved method for performing coronary bypass in a patient, said method including the steps of creating an arterial blood source and connecting the created arterial blood source to a location in a coronary artery downstream from an occlusion, wherein the improvement comprises performing said steps using percutaneously introduced tools while viewing said steps using a percutaneously introduced viewing scope.
27. A system for facilitating a closed chest surgical procedure on or around the exterior of a patient's heart comprising:
a scope for viewing the interior of the patient's chest cavity which can be inserted through a small opening in the patient's chest;
means for occluding the patient's ascending aorta at a location between the patient's coronary arteries and the brachiocephalic artery;
a cardiopulmonary bypass system, including means to direct oxygenated blood into the patient's arterial system downstream from the occluded ascending aorta;
means for inducing cardioplegia; and surgical tools for operating on and around the external surface of the heart.
a scope for viewing the interior of the patient's chest cavity which can be inserted through a small opening in the patient's chest;
means for occluding the patient's ascending aorta at a location between the patient's coronary arteries and the brachiocephalic artery;
a cardiopulmonary bypass system, including means to direct oxygenated blood into the patient's arterial system downstream from the occluded ascending aorta;
means for inducing cardioplegia; and surgical tools for operating on and around the external surface of the heart.
28. The system of claim 27, wherein the means to occlude the ascending aorta is an elongated aortic catheter having proximal and distal ends and an expandable member on a distal portion thereof, the catheter being adapted to be advanced through the patient's aorta until the expandable member on the distal portion is disposed at a location between the ostia of the coronary arteries and the brachiocephalic artery and the expandable member being shaped and dimensioned so that, upon the expansion thereof within the patient's ascending aorta, the aortic passageway therethrough is occluded.
29. The system of claim 27, wherein the means to occlude the ascending aorta includes a clamp adapted to be applied to the exterior of the ascending aorta at a location between the coronary arteries and the brachiocephalic artery.
30. The system of claim 27, wherein the cardiopulmonary bypass system includes means to withdraw blood from the patient's venous system, means to remove carbon dioxide from the withdrawn blood, and means to oxygenate the withdrawn blood which is directed into the patient's arterial system downstream of the occluded ascending aorta.
31. The system of claim 27, further comprising a plurality of trocar sheaths which can be disposed within a relatively small opening in the patient's chest to define an introducing path for the viewing scope and surgical tools.
32. A system for performing a coronary artery bypass graft procedure comprising:
a viewing scope to observe a procedure within a patient's chest cavity, which can be inserted into the chest cavity through a relatively small opening in the patient's chest;
means to occlude the patient's ascending aorta at a location between the patient's coronary arteries and the brachiocephalic trunk;
a cardiopulmonary bypass system including means to withdraw blood from the patient's venous system, means to remove carbon dioxide from the withdrawn blood, means to oxygenate the withdrawn blood and means to direct the oxygenated blood into the patient's arterial system downstream of the occluded ascending aorta;
means to induce cardioplegia;
a first cutting tool which can be inserted into the chest cavity through a small opening in the patient's chest, to transect an artery under observation through the viewing scope to provide a free upstream arterial end within the chest cavity;
a second cutting tool which can be inserted into the chest cavity through a relatively small opening in the patient's chest, to form an incision in a coronary artery downstream from a blockage therein under observation through the viewing scope; and means which can be inserted into the chest cavity through an opening in the patient's chest, for securing the free upstream end of the transected artery to the coronary artery about the incision therein under observation through the viewing scope.
a viewing scope to observe a procedure within a patient's chest cavity, which can be inserted into the chest cavity through a relatively small opening in the patient's chest;
means to occlude the patient's ascending aorta at a location between the patient's coronary arteries and the brachiocephalic trunk;
a cardiopulmonary bypass system including means to withdraw blood from the patient's venous system, means to remove carbon dioxide from the withdrawn blood, means to oxygenate the withdrawn blood and means to direct the oxygenated blood into the patient's arterial system downstream of the occluded ascending aorta;
means to induce cardioplegia;
a first cutting tool which can be inserted into the chest cavity through a small opening in the patient's chest, to transect an artery under observation through the viewing scope to provide a free upstream arterial end within the chest cavity;
a second cutting tool which can be inserted into the chest cavity through a relatively small opening in the patient's chest, to form an incision in a coronary artery downstream from a blockage therein under observation through the viewing scope; and means which can be inserted into the chest cavity through an opening in the patient's chest, for securing the free upstream end of the transected artery to the coronary artery about the incision therein under observation through the viewing scope.
33. The system of claim 32, wherein the cardioplegia inducing means comprises a catheter for introducing cardioplegic material into at least one of the patient's coronary blood vessels.
34. The system of claim 32, further comprising a plurality of trocar sheaths which can be disposed within the relatively small openings in the patient's chest to define an introducing path for the viewing scope and surgical tools.
35. A system as in claim 30, further comprising a coronary sinus catheter which permits retrograde delivery of cardioplegic fluid to the heart.
36. A system as in claim 30, further comprising a pulmonary venting catheter which can vent fluid from the pulmonary trunk and decompress the left ventricle.
37. A system as in claim 30, further comprising an aortic root vent catheter which may be introduced through the aortic occlusion catheter to vent the left ventricle.
38. A system for performing a coronary artery bypass graft procedure in a patient including:
an aortic occlusion catheter;
a first cutting tool which can be inserted into the patient's chest cavity through a small opening in the patient's chest to create an arterial blood source within the patient's chest cavity by severing an artery and providing a free, upstream end of the artery within the chest cavity under observation through a percutaneously introduced viewing scope;
a second cutting tool which can be inserted into the patient's chest cavity through a small opening in the patient's chest to form an incision in a coronary artery downstream from a blockage therein under observation through a percutaneously introduced viewing scope; and means which can be inserted into the patient's chest cavity through a small opening in the patient's chest for securing the free, upstream end of the severed artery to the coronary artery about the incision therein under observation through the viewing scope.
an aortic occlusion catheter;
a first cutting tool which can be inserted into the patient's chest cavity through a small opening in the patient's chest to create an arterial blood source within the patient's chest cavity by severing an artery and providing a free, upstream end of the artery within the chest cavity under observation through a percutaneously introduced viewing scope;
a second cutting tool which can be inserted into the patient's chest cavity through a small opening in the patient's chest to form an incision in a coronary artery downstream from a blockage therein under observation through a percutaneously introduced viewing scope; and means which can be inserted into the patient's chest cavity through a small opening in the patient's chest for securing the free, upstream end of the severed artery to the coronary artery about the incision therein under observation through the viewing scope.
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US08/023,778 US5452733A (en) | 1993-02-22 | 1993-02-22 | Methods for performing thoracoscopic coronary artery bypass |
US08/023,778 | 1993-02-22 |
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CA002154354A Abandoned CA2154354A1 (en) | 1993-02-22 | 1994-01-10 | Method for performing thoracoscopic cardiac bypass procedures |
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CA (1) | CA2154354A1 (en) |
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1994
- 1994-01-10 WO PCT/US1994/000305 patent/WO1994018881A1/en active IP Right Grant
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1999
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2001
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AU688303B2 (en) | 1998-03-12 |
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US5855210A (en) | 1999-01-05 |
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